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Barry Komm

Research Profile

Chemicals & Drugs

Anatomy

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TOP 3
Joshua D Stender; Kyuri Kim; Tze Howe Charn; Barry S Komm; Ken C N Chang; W Lee Kraus; Christopher Benner; Christopher K Glass; Benita S Katzenellenbogen
Genome-wide analysis of estrogen receptor alpha DNA binding and tethering mechanisms identifies Runx1 as a novel tethering factor in receptor-mediated transcriptional activation.
Tripti Gaur; John J Wixted; Sadiq Hussain; Shannon L O'Connell; Elise F Morgan; David C Ayers; Barry S Komm; Peter V N Bodine; Gary S Stein; Jane B Lian
Secreted frizzled related protein 1 is a target to improve fracture healing.
Peter V N Bodine; Barbara Stauffer; Helga Ponce-de-Leon; Ramesh A Bhat; Annamarie Mangine; Laura M Seestaller-Wehr; Robert A Moran; Julia Billiard; Shoichi Fukayama; Barry S Komm; Keith Pitts; Girija Krishnamurthy; Ariamala Gopalsamy; Mengxiao Shi; Jeffrey C Kern; Thomas J Commons; Richard P Woodworth; Matthew A Wilson; Gregory S Welmaker; Eugene J Trybulski; William J Moore
A small molecule inhibitor of the Wnt antagonist secreted frizzled-related protein-1 stimulates bone formation.

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All Publications

2010: Joshua D Stender; Kyuri Kim; Tze Howe Charn; Barry S Komm; Ken C N Chang; W Lee Kraus; Christopher Benner; Christopher K Glass; Benita S Katzenellenbogen
Genome-wide analysis of estrogen receptor alpha DNA binding and tethering mechanisms identifies Runx1 as a novel tethering factor in receptor-mediated transcriptional activation.
Molecular and cellular biology 2010;30(16):3943-55.
2009: Tripti Gaur; John J Wixted; Sadiq Hussain; Shannon L O'Connell; Elise F Morgan; David C Ayers; Barry S Komm; Peter V N Bodine; Gary S Stein; Jane B Lian
Secreted frizzled related protein 1 is a target to improve fracture healing.
Journal of cellular physiology 2009;220(1):174-81.
2009: Peter V N Bodine; Barbara Stauffer; Helga Ponce-de-Leon; Ramesh A Bhat; Annamarie Mangine; Laura M Seestaller-Wehr; Robert A Moran; Julia Billiard; Shoichi Fukayama; Barry S Komm; Keith Pitts; Girija Krishnamurthy; Ariamala Gopalsamy; Mengxiao Shi; Jeffrey C Kern; Thomas J Commons; Richard P Woodworth; Matthew A Wilson; Gregory S Welmaker; Eugene J Trybulski; William J Moore
A small molecule inhibitor of the Wnt antagonist secreted frizzled-related protein-1 stimulates bone formation.
Bone 2009;44(6):1063-8.
2008: Yogendra Kharode; Peter V N Bodine; Christopher P Miller; C Richard Lyttle; Barry S Komm
The pairing of a selective estrogen receptor modulator, bazedoxifene, with conjugated estrogens as a new paradigm for the treatment of menopausal symptoms and osteoporosis prevention.
Endocrinology 2008;149(12):6084-91.
2008: Brune Trevant; Tripti Gaur; Sadiq Hussain; John Symons; Barry S Komm; Peter V N Bodine; Gary S Stein; Jane B Lian
Expression of secreted frizzled related protein 1, a Wnt antagonist, in brain, kidney, and skeleton is dispensable for normal embryonic development.
Journal of cellular physiology 2008;217(1):113-26.
2008: Zeynep Madak-Erdogan; Karen J Kieser; Sung Hoon Kim; Barry S Komm; John A Katzenellenbogen; Benita S Katzenellenbogen
Nuclear and extranuclear pathway inputs in the regulation of global gene expression by estrogen receptors.
Molecular endocrinology (Baltimore, Md.) 2008;22(9):2116-27.
2008: Judy S Crabtree; Bryan J Peano; Xiaochun Zhang; Barry S Komm; Richard Winneker; Heather A Harris
Activity of three selective estrogen receptor modulators on hormone-dependent responses in the mouse uterus and mammary gland.
Molecular and cellular endocrinology 2008;287(1-2):40-6.
2008: Amelia L M Sutton; Xiaoxue Zhang; Diane R Dowd; Yogendra P Kharode; Barry S Komm; Paul N MacDonald
Semaphorin 3B is a 1,25-Dihydroxyvitamin D3-induced gene in osteoblasts that promotes osteoclastogenesis and induces osteopenia in mice.
Molecular endocrinology (Baltimore, Md.) 2008;22(6):1370-81.
2008: Edmund C Chang; Tze Howe Charn; Sung-Hee Park; William G Helferich; Barry S Komm; John A Katzenellenbogen; Benita S Katzenellenbogen
Estrogen Receptors alpha and beta as determinants of gene expression: influence of ligand, dose, and chromatin binding.
Molecular endocrinology (Baltimore, Md.) 2008;22(5):1032-43.
2007: Ramesh A Bhat; Barbara Stauffer; Barry S Komm; Peter V N Bodine
Structure-function analysis of secreted frizzled-related protein-1 for its Wnt antagonist function.
Journal of cellular biochemistry 2007;102(6):1519-28.
2007: Joshua D Stender; Jonna Frasor; Barry S Komm; Ken C N Chang; W Lee Kraus; Benita S Katzenellenbogen
Estrogen-regulated gene networks in human breast cancer cells: involvement of E2F1 in the regulation of cell proliferation.
Molecular endocrinology (Baltimore, Md.) 2007;21(9):2112-23.
2007: Yan Liu; Ramesh A Bhat; Laura M Seestaller-Wehr; Shoichi Fukayama; Annamarie Mangine; Robert A Moran; Barry S Komm; Peter V N Bodine; Julia Billiard
The orphan receptor tyrosine kinase Ror2 promotes osteoblast differentiation and enhances ex vivo bone formation.
Molecular endocrinology (Baltimore, Md.) 2007;21(2):376-87.
2007: Peter V N Bodine; Laura M Seestaller-Wehr; Yogendra P Kharode; Frederick J Bex; Barry S Komm
Bone anabolic effects of parathyroid hormone are blunted by deletion of the Wnt antagonist secreted frizzled-related protein-1.
Journal of cellular physiology 2007;210(2):352-7.
2006: John A Robinson; Moitreyee Chatterjee-Kishore; Paul J Yaworsky; Diane M Cullen; Weiguang Zhao; Christine Li; Yogendra P Kharode; Linda Sauter; Philip Babij; Eugene L Brown; Andrew A Hill; Mohammed P Akhter; Mark L Johnson; Robert R Recker; Barry S Komm; Frederick J Bex
Wnt/beta-catenin signaling is a normal physiological response to mechanical loading in bone.
The Journal of biological chemistry 2006;281(42):31720-8.
2006: Edmund C Chang; Jonna Frasor; Barry S Komm; Benita S Katzenellenbogen
Impact of estrogen receptor beta on gene networks regulated by estrogen receptor alpha in breast cancer cells.
Endocrinology 2006;147(10):4831-42.
2006: Jonna Frasor; Edmund C Chang; Barry S Komm; Chin-Yo Lin; Vinsensius B Vega; Edison Liu; Lance D Miller; Johanna Smeds; Jonas Bergh; Benita S Katzenellenbogen
Gene expression preferentially regulated by tamoxifen in breast cancer cells and correlations with clinical outcome.
Cancer research 2006;66(14):7334-40.
2006: Tripti Gaur; Lillian Rich; Christopher J Lengner; Sadiq Hussain; Brune Trevant; David Ayers; Janet L Stein; Peter V N Bodine; Barry S Komm; Gary S Stein; Jane B Lian
Secreted frizzled related protein 1 regulates Wnt signaling for BMP2 induced chondrocyte differentiation.
Journal of cellular physiology 2006;208(1):87-96.
2006: Peter V N Bodine; Barry S Komm
Wnt signaling and osteoblastogenesis.
Reviews in endocrine & metabolic disorders 2006;7(1-2):33-9.
2005: Peter V N Bodine; Julia Billiard; Robert A Moran; Helga Ponce-de-Leon; Sean McLarney; Annamarie Mangine; Melissa J Scrimo; Ramesh A Bhat; Barbara Stauffer; Jack Green; Gary S Stein; Jane B Lian; Barry S Komm
The Wnt antagonist secreted frizzled-related protein-1 controls osteoblast and osteocyte apoptosis.
Journal of cellular biochemistry 2005;96(6):1212-30.
2005: Tripti Gaur; Christopher J Lengner; Hayk Hovhannisyan; Ramesh A Bhat; Peter V N Bodine; Barry S Komm; Amjad Javed; Andre J van Wijnen; Janet L Stein; Gary S Stein; Jane B Lian
Canonical WNT signaling promotes osteogenesis by directly stimulating Runx2 gene expression.
The Journal of biological chemistry 2005;280(39):33132-40.
2005: Barry S Komm; Yogendra P Kharode; Peter V N Bodine; Heather A Harris; Chris P Miller; C Richard Lyttle
Bazedoxifene acetate: a selective estrogen receptor modulator with improved selectivity.
Endocrinology 2005;146(9):3999-4008.
2004: Ramesh A Bhat; Barbara Stauffer; Barry S Komm; Peter V N Bodine
Regulated expression of sFRP-1 protein by the GeneSwitch system.
Protein expression and purification 2004;37(2):327-35.
2004: Fabio Stossi; Daniel Barnett; Jonna Frasor; Barry S Komm; C Richard Lyttle; Benita S Katzenellenbogen
Transcriptional profiling of estrogen-regulated gene expression via estrogen receptor (ER) alpha or ERbeta in human osteosarcoma cells: distinct and common target genes for these receptors.
Endocrinology 2004;145(7):3473-86.
2004: Peter V N Bodine; Weiguang Zhao; Yogendra P Kharode; Frederick J Bex; Andre-Jean Lambert; Mary Beth Goad; Tripti Gaur; Gary S Stein; Jane B Lian; Barry S Komm
The Wnt antagonist secreted frizzled-related protein-1 is a negative regulator of trabecular bone formation in adult mice.
Molecular endocrinology (Baltimore, Md.) 2004;18(5):1222-37.
2004: Frank Barletta; Chi-Wai Wong; Chris McNally; Barry S Komm; Benita S Katzenellenbogen; Boris J Cheskis
Characterization of the interactions of estrogen receptor and MNAR in the activation of cSrc.
Molecular endocrinology (Baltimore, Md.) 2004;18(5):1096-108.
2004: Jonna Frasor; Fabio Stossi; Jeanne M Danes; Barry S Komm; C Richard Lyttle; Benita S Katzenellenbogen
Selective estrogen receptor modulators: discrimination of agonistic versus antagonistic activities by gene expression profiling in breast cancer cells.
Cancer research 2004;64(4):1522-33.
2004: C Richard Lyttle; Barry S Komm; Boris J Cheskis
Estrogens: from classical endocrine action to tissue selective action.
Ernst Schering Research Foundation workshop 2004;(46):1-21.
2004: Ramesh A Bhat; Barbara Stauffer; Rayomand J Unwalla; Zhangbao Xu; Heather A Harris; Barry S Komm
Molecular determinants of ER alpha and ER beta involved in selectivity of 16 alpha-iodo-7 beta estradiol.
The Journal of steroid biochemistry and molecular biology 2004;88(1):17-26.
2003: Heather A Harris; Leo M Albert; Yelena Leathurby; Michael S Malamas; Richard E Mewshaw; Chris P Miller; Yogendra P Kharode; James Marzolf; Barry S Komm; Richard Winneker; Donald E Frail; Ruth A Henderson; Yuan Zhu; James Carl Keith
Evaluation of an estrogen receptor-beta agonist in animal models of human disease.
Endocrinology 2003;144(10):4241-9.
2003: Jonna Frasor; Jeanne M Danes; Barry S Komm; Ken C N Chang; C Richard Lyttle; Benita S Katzenellenbogen
Profiling of estrogen up- and down-regulated gene expression in human breast cancer cells: insights into gene networks and pathways underlying estrogenic control of proliferation and cell phenotype.
Endocrinology 2003;144(10):4562-74.
2003: Julia Billiard; Robert A Moran; Maryann Z Whitley; Moitreyee Chatterjee-Kishore; K Gillis; Eugene L Brown; Barry S Komm; Peter V N Bodine
Transcriptional profiling of human osteoblast differentiation.
Journal of cellular biochemistry 2003;89(2):389-400.
2003: Boris J Cheskis; Neil J McKenna; Chi-Wai Wong; Jiemin Wong; Barry S Komm; C Richard Lyttle; Bert W O'Malley
Hierarchical affinities and a bipartite interaction model for estrogen receptor isoforms and full-length steroid receptor coactivator (SRC/p160) family members.
The Journal of biological chemistry 2003;278(15):13271-7.
2003: Shuanhu Zhou; Gadi Turgeman; Stephen E Harris; Dale C Leitman; Barry S Komm; Peter V N Bodine; Dan Gazit
Estrogens activate bone morphogenetic protein-2 gene transcription in mouse mesenchymal stem cells.
Molecular endocrinology (Baltimore, Md.) 2003;17(1):56-66.
2002: Chi-Wai Wong; Christopher McNally; Elliot Nickbarg; Barry S Komm; Boris J Cheskis
Estrogen receptor-interacting protein that modulates its nongenomic activity-crosstalk with Src/Erk phosphorylation cascade.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(23):14783-8.
2002: Peter V N Bodine; Heather A Harris; C Richard Lyttle; Barry S Komm
Estrogenic effects of 7alpha-methyl-17alpha-ethynylestradiol: a newly discovered tibolone metabolite.
Steroids 2002;67(8):681-6.
2002: Maria Claudia Perez; Peter V N Bodine; Maria C Leiva; Keith B Isaacson; Barry S Komm
Signal transduction pathways involved in macrophage migration induced by peritoneal fluid chemotactic factors in stages I and II endometriosis.
Fertility and sterility 2002;77(6):1261-8.
2002: Gadi Turgeman; Yoram Zilberman; Shuanhu Zhou; Pam Kelly; Ioannis K Moutsatsos; Yogendra P Kharode; Luis E Borella; Frederick J Bex; Barry S Komm; Peter V N Bodine; Dan Gazit
Systemically administered rhBMP-2 promotes MSC activity and reverses bone and cartilage loss in osteopenic mice.
Journal of cellular biochemistry 2002;86(3):461-74.
2002: Peter V N Bodine; Barry S Komm
Tissue culture models for studies of hormone and vitamin action in bone cells.
Vitamins and hormones 2002;64():101-51.
2001: Barry S Komm; C Richard Lyttle
Developing a SERM: stringent preclinical selection criteria leading to an acceptable candidate (WAY-140424) for clinical evaluation.
Annals of the New York Academy of Sciences 2001;949():317-26.
2001: Lee M Greenberger; Tami Annable; K I Collins; Barry S Komm; C Richard Lyttle; Chris P Miller; P G Satyaswaroop; Yixian Zhang; Philip Frost
A new antiestrogen, 2-(4-hydroxy-phenyl)-3-methyl-1-[4-(2-piperidin-1-yl-ethoxy)-benzyl]-1H-indol-5-ol hydrochloride (ERA-923), inhibits the growth of tamoxifen-sensitive and -resistant tumors and is devoid of uterotropic effects in mice and rats.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(10):3166-77.
2001: Chi-Wai Wong; Barry S Komm; Boris J Cheskis
Structure-function evaluation of ER alpha and beta interplay with SRC family coactivators. ER selective ligands.
Biochemistry 2001;40(23):6756-65.
2001: Chris P Miller; Michael D Collini; B D Tran; Heather A Harris; Yogendra P Kharode; James Marzolf; R A Moran; Ruth A Henderson; R H Bender; Rayomand J Unwalla; Lee M Greenberger; JP Yardley; Magid A Abou-Gharbia; C Richard Lyttle; Barry S Komm
Design, synthesis, and preclinical characterization of novel, highly selective indole estrogens.
Journal of medicinal chemistry 2001;44(11):1654-7.
2001: H Harris; R Henderson; R Bhat; Barry S Komm
Regulation of metallothionein II messenger ribonucleic acid measures exogenous estrogen receptor-beta activity in SAOS-2 and LNCaPLN3 cells.
Endocrinology 2001;142(2):645-52.
2001: M Prince; C Banerjee; Amjad Javed; J Green; Jane B Lian; Gary S Stein; Peter V N Bodine; Barry S Komm
Expression and regulation of Runx2/Cbfa1 and osteoblast phenotypic markers during the growth and differentiation of human osteoblasts.
Journal of cellular biochemistry 2001;80(3):424-40.
2000: Chris P Miller; I Jirkovsky; B D Tran; Heather A Harris; R A Moran; Barry S Komm
Synthesis and estrogenic activities of novel 7-thiosubstituted estratriene derivatives.
Bioorganic & medicinal chemistry letters 2000;10(2):147-51.
1999: Peter V N Bodine; Barry S Komm
Evidence that conditionally immortalized human osteoblasts express an osteocalcin receptor.
Bone 1999;25(5):535-43.
1999: Peter V N Bodine; Heather A Harris; Barry S Komm
Suppression of ligand-dependent estrogen receptor activity by bone-resorbing cytokines in human osteoblasts.
Endocrinology 1999;140(6):2439-51.
1998: Ramesh A Bhat; Douglas C Harnish; Panayiotis E Stevis; C Richard Lyttle; Barry S Komm
A novel human estrogen receptor beta: identification and functional analysis of additional N-terminal amino acids.
The Journal of steroid biochemistry and molecular biology 1998;67(3):233-40.
1998: Peter V N Bodine; R A Henderson; J Green; M Aronow; T Owen; Gary S Stein; Jane B Lian; Barry S Komm
Estrogen receptor-alpha is developmentally regulated during osteoblast differentiation and contributes to selective responsiveness of gene expression.
Endocrinology 1998;139(4):2048-57.
1998: Barry S Komm; Peter V N Bodine
The ongoing saga of osteoporosis treatment.
Journal of cellular biochemistry. Supplement 1998;30-31():277-83.
1997: Heather A Harris; Richard Murrills; Barry S Komm
Expression of meltrin-alpha mRNA is not restricted to fusagenic cells.
Journal of cellular biochemistry 1997;67(1):136-42.
1997: Peter V N Bodine; J Green; Heather A Harris; Ramesh A Bhat; Gary S Stein; Jane B Lian; Barry S Komm
Functional properties of a conditionally phenotypic, estrogen-responsive, human osteoblast cell line.
Journal of cellular biochemistry 1997;65(3):368-87.
1996: Paul J Shughrue; Barry S Komm; Istvan Merchenthaler
The distribution of estrogen receptor-beta mRNA in the rat hypothalamus.
Steroids 1996;61(12):678-81.
1996: Peter V N Bodine; S K Vernon; Barry S Komm
Establishment and hormonal regulation of a conditionally transformed preosteocytic cell line from adult human bone.
Endocrinology 1996;137(11):4592-604.
1996: Peter V N Bodine; M Trailsmith; Barry S Komm
Development and characterization of a conditionally transformed adult human osteoblastic cell line.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1996;11(6):806-19.
1996: C Liu; K Wallace; C Shi; S Heyner; Barry S Komm; JG Haddad
Post-transcriptional stimulation of transforming growth factor beta 1 mRNA by TGF-beta 1 treatment of transformed human osteoblasts.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1996;11(2):211-17.
1990: E O Brown; S A Sundstrom; Barry S Komm; Z Yi; Cory Teuscher; C R Lyttle
Progesterone regulation of estradiol-induced rat uterine secretory protein, complement C3.
Biology of reproduction 1990;42(4):713-9.
1990: S A Sundstrom; Barry S Komm; Q Xu; V Boundy; C R Lyttle
The stimulation of uterine complement component C3 gene expression by antiestrogens.
Endocrinology 1990;126(3):1449-56.
1989: S A Sundstrom; Barry S Komm; H Ponce-de-Leon; Z Yi; Cory Teuscher; C R Lyttle
Estrogen regulation of tissue-specific expression of complement C3.
The Journal of biological chemistry 1989;264(28):16941-7.
1988: F R Frankel; C Y Hsu; J C Myers; E Lin; C R Lyttle; Barry S Komm; K Mohn
Regulation of alpha 2(I), alpha 1(III), and alpha 2(V) collagen mRNAs by estradiol in the immature rat uterus.
DNA (Mary Ann Liebert, Inc.) 1988;7(5):347-54.
1988: C Y Hsu; Barry S Komm; C R Lyttle; F Frankel
Cloning of estrogen-regulated messenger ribonucleic acids from rat uterus.
Endocrinology 1988;122(2):631-9.
1987: Barry S Komm; F R Frankel; J C Myers; C R Lyttle
Estrogen regulation of alpha 1(I)-procollagen messenger ribonucleic acid in the rat uterus.
Endocrinology 1987;120(4):1403-10.
1987: C Wheeler; Barry S Komm; C R Lyttle
Estrogen regulation of protein synthesis in the immature rat uterus: the effects of progesterone on proteins released into the medium during in vitro incubations.
Endocrinology 1987;120(3):919-23.
1987: C R Lyttle; C Wheeler; Barry S Komm
Hormonal regulation of rat uterine secretory protein synthesis.
Advances in experimental medicine and biology 1987;230():119-36.
1986: Barry S Komm; D J Rusling; C R Lyttle
Estrogen regulation of protein synthesis in the immature rat uterus: the analysis of proteins released into the medium during in vitro incubation.
Endocrinology 1986;118(6):2411-6.
1985: Barry S Komm; Hugh Keeping; G Sabogal; C R Lyttle
Comparison of media proteins from ovariectomized rat uteri following estrogen treatment.
Biology of reproduction 1985;32(2):443-50.
1984: Barry S Komm; C R Lyttle
Steroidal regulation of rat uterine in vitro mRNA translation products.
Journal of steroid biochemistry 1984;21(5):571-7.