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Valentina Kon

Research Profile

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Chemicals & Drugs

Anatomy

Physiology

Glomerular Filtration Rate

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Suguru Yamamoto; Patricia G Yancey; MacRae F Linton; Ayumi Shintani; Aihua Bian; Brian Cox; Sergio Fazio; Agnes B Fogo; T Alp Ikizler; W Gray Jerome; Ryohei Kaseda; Valentina Kon
Dysfunctional high-density lipoprotein in patients on chronic hemodialysis.
Nobuaki Takagi; Takakuni Tanizawa; Agnes B Fogo; Iekuni Ichikawa; Valentina Kon; Ji Ma
Mineralocorticoid Receptor Blocker Protects against Podocyte-Dependent Glomerulosclerosis.
Petra A Prins; Aramandla Ramesh; Sergio Fazio; ZhongMao Guo; Valentina Kon; MacRae F Linton; Prudhvidhar R Perati; Uchechukwu K Sampson
Benzo[a]pyrene potentiates the pathogenesis of abdominal aortic aneurysms in apolipoprotein E knockout mice.

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2012: Suguru Yamamoto; Patricia G Yancey; MacRae F Linton; Ayumi Shintani; Aihua Bian; Brian Cox; Sergio Fazio; Agnes B Fogo; T Alp Ikizler; W Gray Jerome; Ryohei Kaseda; Valentina Kon
Dysfunctional high-density lipoprotein in patients on chronic hemodialysis.
Journal of the American College of Cardiology 2012;60(23):2372-9.
2012: Nobuaki Takagi; Takakuni Tanizawa; Agnes B Fogo; Iekuni Ichikawa; Valentina Kon; Ji Ma
Mineralocorticoid Receptor Blocker Protects against Podocyte-Dependent Glomerulosclerosis.
Nephron extra 2012;2(1):17-26.
2012: Petra A Prins; Aramandla Ramesh; Sergio Fazio; ZhongMao Guo; Valentina Kon; MacRae F Linton; Prudhvidhar R Perati; Uchechukwu K Sampson
Benzo[a]pyrene potentiates the pathogenesis of abdominal aortic aneurysms in apolipoprotein E knockout mice.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2012;29(1-2):121-30.
2011: Suguru Yamamoto; Patricia G Yancey; Yiqin Zuo; MacRae F Linton; Li-Jun Ma; Sergio Fazio; Agnes B Fogo; Iekuni Ichikawa; Ryohei Kaseda; Valentina Kon
Macrophage polarization by angiotensin II-type 1 receptor aggravates renal injury-acceleration of atherosclerosis.
Arteriosclerosis, thrombosis, and vascular biology 2011;31(12):2856-64.
2011: Taiji Matsusaka; Ira Pastan; Eric Sandgren; Ayumi Shintani; Agnes B Fogo; Valentina Kon; Iekuni Ichikawa
Podocyte injury damages other podocytes.
Journal of the American Society of Nephrology : JASN 2011;22(7):1275-85.
2011: Uchechukwu K Sampson; Prudhvidhar R Perati; Petra A Prins; Wellington Pham; Zhouwen Liu; Frank E Harrell; MacRae F Linton; John C Gore; Valentina Kon; Sergio Fazio
Quantitative estimates of the variability of in vivo sonographic measurements of the mouse aorta for studies of abdominal aortic aneurysms and related arterial diseases.
Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine 2011;30(6):773-84.
2011: Li-Jun Ma; Bridgette A Corsa; Jun Zhou; HaiChun Yang; Haijing Li; Yi-Wei Tang; Vladimir R Babaev; Amy S Major; MacRae F Linton; Sergio Fazio; Tracy E Hunley; Valentina Kon; Agnes B Fogo
Angiotensin type 1 receptor modulates macrophage polarization and renal injury in obesity.
American journal of physiology. Renal physiology 2011;300(5):F1203-13.
2011: Valentina Kon; MacRae F Linton; Sergio Fazio
Atherosclerosis in chronic kidney disease: the role of macrophages.
Nature reviews. Nephrology 2011;7(1):45-54.
2010: Agnes B Fogo; Valentina Kon
The glomerulus--a view from the inside--the endothelial cell.
The international journal of biochemistry & cell biology 2010;42(9):1388-97.
2010: Tracy E Hunley; Li-Jun Ma; Valentina Kon
Scope and mechanisms of obesity-related renal disease.
Current opinion in nephrology and hypertension 2010;19(3):227-34.
2010: Takashi Naito; Li-Jun Ma; Haichun Yang; Yiqin Zuo; Yiwei Tang; Jee Young Han; Valentina Kon; Agnes B Fogo
Angiotensin type 2 receptor actions contribute to angiotensin type 1 receptor blocker effects on kidney fibrosis.
American journal of physiology. Renal physiology 2010;298(3):F683-91.
2010: Masaru Motojima; Taiji Matsusaka; Valentina Kon; Iekuni Ichikawa
Fibrinogen that appears in Bowman's space of proteinuric kidneys in vivo activates podocyte Toll-like receptors 2 and 4 in vitro.
Nephron. Experimental nephrology 2010;114(2):e39-47.
2009: Yiqin Zuo; Patricia G Yancey; Iris Castro; Wasif Khan; Wasif Khan; Masaru Motojima; Iekuni Ichikawa; Agnes B Fogo; MacRae F Linton; Sergio Fazio; Valentina Kon
Renal dysfunction potentiates foam cell formation by repressing ABCA1.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(9):1277-82.
2009: Suguru Yamamoto; Valentina Kon
Mechanisms for increased cardiovascular disease in chronic kidney dysfunction.
Current opinion in nephrology and hypertension 2009;18(3):181-8.
2007: Eisuke Suganuma; Vladimir R Babaev; Masaru Motojima; Yiqin Zuo; Nobuhiko Ayabe; Agnes B Fogo; Iekuni Ichikawa; MacRae F Linton; Sergio Fazio; Valentina Kon
Angiotensin inhibition decreases progression of advanced atherosclerosis and stabilizes established atherosclerotic plaques.
Journal of the American Society of Nephrology : JASN 2007;18(8):2311-9.
2006: Fumio Niimura; Valentina Kon; Iekuni Ichikawa
The renin-angiotensin system in the development of the congenital anomalies of the kidney and urinary tract.
Current opinion in pediatrics 2006;18(2):161-6.
2006: Eisuke Suganuma; Yiqin Zuo; Nobuhiko Ayabe; Ji Ma; Vladimir R Babaev; MacRae F Linton; Sergio Fazio; Iekuni Ichikawa; Agnes B Fogo; Valentina Kon
Antiatherogenic effects of angiotensin receptor antagonism in mild renal dysfunction.
Journal of the American Society of Nephrology : JASN 2006;17(2):433-41.
2006: Nobuhiko Ayabe; Vladimir R Babaev; Yiwei Tang; Takakuni Tanizawa; Agnes B Fogo; MacRae F Linton; Iekuni Ichikawa; Sergio Fazio; Valentina Kon
Transiently heightened angiotensin II has distinct effects on atherosclerosis and aneurysm formation in hyperlipidemic mice.
Atherosclerosis 2006;184(2):312-21.
2005: Baogang J Xu; Yu Shyr; Xiubin Liang; Li-Jun Ma; Ellen M Donnert; Jeremy D Roberts; Xueqiong Zhang; Valentina Kon; Nancy Brown; Richard M Caprioli; Agnes B Fogo
Proteomic patterns and prediction of glomerulosclerosis and its mechanisms.
Journal of the American Society of Nephrology : JASN 2005;16(10):2967-75.
2005: Vladimir R Babaev; Patricia G Yancey; Sergey V Ryzhov; Valentina Kon; Matthew D Breyer; Mark Magnuson; Sergio Fazio; MacRae F Linton
Conditional knockout of macrophage PPARgamma increases atherosclerosis in C57BL/6 and low-density lipoprotein receptor-deficient mice.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(8):1647-53.
2004: Ayabe Nobuhiko; Eisuke Suganuma; Vladimir R Babaev; Agnes Fogo; Larry L Swift; MacRae F Linton; Sergio Fazio; Iekuni Ichikawa; Valentina Kon
Angiotensin II amplifies macrophage-driven atherosclerosis.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(11):2143-8.
2004: Ji Ma; Taiji Matsusaka; Haichun Yang; Hiroshi Kawachi; Fujio Shimizu; Yoshitaka Isaka; Enyu Imai; Valentina Kon; Iekuni Ichikawa
Local actions of endogenous angiotensin II in injured glomeruli.
Journal of the American Society of Nephrology : JASN 2004;15(5):1268-76.
2004: Valentina Kon; Kathy Jabs
Angiotensin in atherosclerosis.
Current opinion in nephrology and hypertension 2004;13(3):291-7.
2002: Masashi Nishida; Hidehiko Fujinaka; Taiji Matsusaka; James Price; Valentina Kon; Agnes B Fogo; Jeffrey M Davidson; MacRae F Linton; Sergio Fazio; Toshio Homma; Hiroaki Yoshida; Iekuni Ichikawa
Absence of angiotensin II type 1 receptor in bone marrow-derived cells is detrimental in the evolution of renal fibrosis.
The Journal of clinical investigation 2002;110(12):1859-68.
2001: Tracy E Hunley; Valentina Kon
Update on endothelins - biology and clinical implications.
Pediatric nephrology (Berlin, Germany) 2001;16(9):752-62.
2000: Valentina Kon; Iekuni Ichikawa
Prospects for gene transfer into renal cells.
Kidney international 2000;57(5):2169-70.
2000: Taiji Matsusaka; Valentina Kon; J Takaya; H Katori; X Chen; J Miyazaki; Toshio Homma; Agnes Fogo; Iekuni Ichikawa
Dual renin gene targeting by Cre-mediated interchromosomal recombination.
Genomics 2000;64(2):127-31.
2000: Tracy E Hunley; Masaaki Tamura; BJ Stoneking; H Nishimura; Toshihiro Ichiki; Tadashi Inagami; Valentina Kon
The angiotensin type II receptor tonically inhibits angiotensin- converting enzyme in AT2 null mutant mice.
Kidney international 2000;57(2):570-7.
1999: Katharina Hohenfellner; Tracy E Hunley; R Brezinska; P Brodhag; Y Shyr; W Brenner; Pirmin Habermehl; Valentina Kon
ACE I/D gene polymorphism predicts renal damage in congenital uropathies.
Pediatric nephrology (Berlin, Germany) 1999;13(6):514-8.
1999: Katharina Hohenfellner; Tracy E Hunley; C Schloemer; W Brenner; Elizabeth B Yerkes; F Zepp; John W Brock; Valentina Kon
Angiotensin type 2 receptor is important in the normal development of the ureter.
Pediatric nephrology (Berlin, Germany) 1999;13(3):187-91.
1999: Tracy E Hunley; Valentina Kon
IgA nephropathy.
Current opinion in pediatrics 1999;11(2):152-7.
1999: Katharina Hohenfellner; Agnes Fogo; Valentina Kon
Renin-angiotensin genes in renal development and the occurrence and progression of renal diseases.
Seminars in nephrology 1999;19(2):148-54.
1999: Katharina Hohenfellner; Tracy E Hunley; Elizabeth B Yerkes; Pirmin Habermehl; Rudolf Hohenfellner; Valentina Kon
Angiotensin II, type 2 receptor in the development of vesico-ureteric reflux.
BJU international 1999;83(3):318-22.
1998: John W Brock; Tracy E Hunley; Mark C Adams; Valentina Kon
Role of the renin-angiotensin system in disorders of the urinary tract.
The Journal of urology 1998;160(5):1812-9.
1998: BJ Stoneking; Tracy E Hunley; H Nishimura; Ji Ma; Agnes Fogo; Tadashi Inagami; Masaaki Tamura; Mark C Adams; John W Brock; Valentina Kon
Renal angiotensin converting enzyme promotes renal damage during ureteral obstruction.
The Journal of urology 1998;160(3 Pt 2):1070-4.
1998: Ji Ma; H Nishimura; Agnes Fogo; Valentina Kon; Tadashi Inagami; Iekuni Ichikawa
Accelerated fibrosis and collagen deposition develop in the renal interstitium of angiotensin type 2 receptor null mutant mice during ureteral obstruction.
Kidney international 1998;53(4):937-44.
1997: James V Gainer; Tracy E Hunley; Valentina Kon; J H Nadeau; James A S Muldowney; Nancy Brown
Angiotensin II type I receptor polymorphism in African Americans lower frequency of the C1166 variant.
Biochemistry and molecular biology international 1997;43(1):227-31.
1997: H Nishimura; Taiji Matsusaka; Agnes Fogo; Valentina Kon; Iekuni Ichikawa
A novel in vivo mechanism for angiotensin type 1 receptor regulation.
Kidney international 1997;52(2):345-55.
1997: Tracy E Hunley; Valentina Kon
Endothelin in ischemic acute renal failure.
Current opinion in nephrology and hypertension 1997;6(4):394-400.
1996: A Fogo; Valentina Kon
Treatment of hypertension.
Seminars in nephrology 1996;16(6):555-66.
1996: Tracy E Hunley; B A Julian; John A Phillips; Marshall Summar; H Yoshida; R G Horn; Nancy Brown; A Fogo; Iekuni Ichikawa; Valentina Kon
Angiotensin converting enzyme gene polymorphism: potential silencer motif and impact on progression in IgA nephropathy.
Kidney international 1996;49(2):571-7.
1995: Valentina Kon; Tracy E Hunley; A Fogo
Combined antagonism of endothelin A/B receptors links endothelin to vasoconstriction whereas angiotensin II effects fibrosis. Studies in chronic cyclosporine nephrotoxicity in rats.
Transplantation 1995;60(1):89-95.
1995: Tracy E Hunley; S Iwasaki; T Homma; Valentina Kon
Nitric oxide and endothelin in pathophysiological settings.
Pediatric nephrology (Berlin, Germany) 1995;9(2):235-44.
1995: S Iwasaki; T Homma; Y Matsuda; Valentina Kon
Endothelin receptor subtype B mediates autoinduction of endothelin-1 in rat mesangial cells.
The Journal of biological chemistry 1995;270(12):6997-7003.
1995: Tracy E Hunley; A Fogo; S Iwasaki; Valentina Kon
Endothelin A receptor mediates functional but not structural damage in chronic cyclosporine nephrotoxicity.
Journal of the American Society of Nephrology : JASN 1995;5(9):1718-23.
1995: S Kiyama; T Yoshioka; I M Burr; Valentina Kon; A Fogo; Iekuni Ichikawa
Strategic locus for the activation of the superoxide dismutase gene in the nephron.
Kidney international 1995;47(2):536-46.
1994: T Yoshioka; T Homma; Barbara Meyrick; M Takeda; T Moore-Jarrett; Valentina Kon; Iekuni Ichikawa
Oxidants induce transcriptional activation of manganese superoxide dismutase in glomerular cells.
Kidney international 1994;46(2):405-13.
1994: M Takeda; S Iwasaki; S E Hellings; H Yoshida; T Homma; Valentina Kon
Divergent expression of EtA and EtB receptors in response to cyclosporine in mesangial cells.
The American journal of pathology 1994;144(3):473-9.
1994: S Iwasaki; T Homma; Valentina Kon
Site specific regulation in the kidney of endothelin and its receptor subtypes by cyclosporine.
Kidney international 1994;45(2):592-7.
1994: R Tanaka; Valentina Kon; T Yoshioka; Iekuni Ichikawa; A Fogo
Angiotensin converting enzyme inhibitor modulates glomerular function and structure by distinct mechanisms.
Kidney international 1994;45(2):537-43.
1993: Valentina Kon; A Fogo
Endothelin: potential role in development and disease.
Pediatric nephrology (Berlin, Germany) 1993;7(6):876-80.
1993: Valentina Kon; A Fogo; Iekuni Ichikawa
Bradykinin causes selective efferent arteriolar dilation during angiotensin I converting enzyme inhibition.
Kidney international 1993;44(3):545-50.
1993: M Takeda; T Homma; Matthew D Breyer; N Horiba; R L Hoover; S Kawamoto; Iekuni Ichikawa; Valentina Kon
Volume and agonist-induced regulation of myosin light-chain phosphorylation in glomerular mesangial cells.
The American journal of physiology 1993;264(3 Pt 2):F421-6.
1992: A Fogo; S E Hellings; Tadashi Inagami; Valentina Kon
Endothelin receptor antagonism is protective in in vivo acute cyclosporine toxicity.
Kidney international 1992;42(3):770-4.
1992: M Takeda; Matthew D Breyer; T D Noland; T Homma; R L Hoover; Tadashi Inagami; Valentina Kon
Endothelin-1 receptor antagonist: effects on endothelin- and cyclosporine-treated mesangial cells.
Kidney international 1992;41(6):1713-9.
1992: Valentina Kon; Midori Awazu
Endothelin and cyclosporine nephrotoxicity.
Renal failure 1992;14(3):345-50.
1991: Midori Awazu; Valentina Kon; Raymond C Harris; T Imada; Tadashi Inagami; Iekuni Ichikawa
Renal sympathetic nerves modulate glomerular ANP receptors and filtration.
The American journal of physiology 1991;261(1 Pt 2):F29-35.
1991: Midori Awazu; M Sugiura; Tadashi Inagami; Iekuni Ichikawa; Valentina Kon
Cyclosporine promotes glomerular endothelin binding in vivo.
Journal of the American Society of Nephrology : JASN 1991;1(11):1253-8.
1991: Midori Awazu; R E Parker; B R Harvie; Iekuni Ichikawa; Valentina Kon
Down-regulation of endothelin-1 receptors by protein kinase C in streptozotocin diabetic rats.
Journal of cardiovascular pharmacology 1991;17 Suppl 7():S500-2.
1990: Iekuni Ichikawa; T Yoshioka; A Fogo; Valentina Kon
Role of angiotensin II in altered glomerular hemodynamics in congestive heart failure.
Kidney international. Supplement 1990;30():S123-6.
1990: Valentina Kon; Iekuni Ichikawa
What is the cause of sodium retention in acute nephritis?
Pediatric nephrology (Berlin, Germany) 1990;4(4):307.
1990: Valentina Kon; M Sugiura; Tadashi Inagami; B R Harvie; Iekuni Ichikawa; R L Hoover
Role of endothelin in cyclosporine-induced glomerular dysfunction.
Kidney international 1990;37(6):1487-91.
1990: A Fogo; R C Hakim; M Sugiura; Tadashi Inagami; Valentina Kon
Severe endothelial injury in a renal transplant patient receiving cyclosporine.
Transplantation 1990;49(6):1190-2.
1990: Valentina Kon; Raymond C Harris; Iekuni Ichikawa
A regulatory role for large vessels in organ circulation. Endothelial cells of the main renal artery modulate intrarenal hemodynamics in the rat.
The Journal of clinical investigation 1990;85(6):1728-33.
1989: Midori Awazu; T Imada; Valentina Kon; Tadashi Inagami; Iekuni Ichikawa
Role of endogenous atrial natriuretic peptide in congestive heart failure.
The American journal of physiology 1989;257(3 Pt 2):R641-6.
1989: M Sugiura; Tadashi Inagami; Valentina Kon
Endotoxin stimulates endothelin-release in vivo and in vitro as determined by radioimmunoassay.
Biochemical and biophysical research communications 1989;161(3):1220-7.
1989: Valentina Kon; M J Karnovsky
Morphologic demonstration of adrenergic influences on the glomerulus.
The American journal of pathology 1989;134(5):1039-46.
1989: Valentina Kon; T Yoshioka; A Fogo; Iekuni Ichikawa
Glomerular actions of endothelin in vivo.
The Journal of clinical investigation 1989;83(5):1762-7.
1989: T Yoshioka; A Yared; Valentina Kon; Iekuni Ichikawa
Impaired preservation of GFR during hypotension in preexistent renal hypoperfusion.
The American journal of physiology 1989;256(2 Pt 2):F314-20.
1985: Valentina Kon; A Yared; Iekuni Ichikawa
Role of renal sympathetic nerves in mediating hypoperfusion of renal cortical microcirculation in experimental congestive heart failure and acute extracellular fluid volume depletion.
The Journal of clinical investigation 1985;76(5):1913-20.
1985: A Yared; Valentina Kon; Iekuni Ichikawa
Mechanism of preservation of glomerular perfusion and filtration during acute extracellular fluid volume depletion. Importance of intrarenal vasopressin-prostaglandin interaction for protecting kidneys from constrictor action of vasopressin.
The Journal of clinical investigation 1985;75(5):1477-87.