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Takeo Konakahara

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Toshimitsu Moriya; Reiko Ikeda; Keita Kawana; Takeo Konakahara; Shinichiro Yoneda; Norio Sakai
Indium-catalyzed reductive bromination of carboxylic acids leading to alkyl bromides.
Norio Sakai; Tomohiro Sakamoto; Takuma Yatsuda; Reiko Ikeda; Takahiro Miyazaki; Toshimitsu Moriya; Takeo Konakahara
Single-step thioetherification by indium-catalyzed reductive coupling of carboxylic acids with thiols.
Reiko Ikeda; Takanori Kimura; Norio Sakai; Syunsuke Tamura; Tatsuya Tsutsumi; Takeo Konakahara
Structure-activity relationship in the antitumor activity of 6-, 8- or 6,8-substituted 3-benzylamino-β-carboline derivatives.

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All Publications

2012: Toshimitsu Moriya; Reiko Ikeda; Keita Kawana; Takeo Konakahara; Shinichiro Yoneda; Norio Sakai
Indium-catalyzed reductive bromination of carboxylic acids leading to alkyl bromides.
Organic letters 2012;14(18):4842-5.
2012: Norio Sakai; Tomohiro Sakamoto; Takuma Yatsuda; Reiko Ikeda; Takahiro Miyazaki; Toshimitsu Moriya; Takeo Konakahara
Single-step thioetherification by indium-catalyzed reductive coupling of carboxylic acids with thiols.
Organic letters 2012;14(17):4366-9.
2012: Reiko Ikeda; Takanori Kimura; Norio Sakai; Syunsuke Tamura; Tatsuya Tsutsumi; Takeo Konakahara
Structure-activity relationship in the antitumor activity of 6-, 8- or 6,8-substituted 3-benzylamino-β-carboline derivatives.
Bioorganic & medicinal chemistry letters 2012;22(10):3506-15.
2012: Hirofumi Sakai; Munehisa Takahashi; Mutsuo Furihata; Toru Imamura; Takeo Konakahara; Chie Matsuda; Hiroshi Miyazaki; Tomoko Okada
Augmented autocrine bone morphogenic protein (BMP) 7 signaling increases the metastatic potential of mouse breast cancer cells.
Clinical & experimental metastasis 2012;29(4):327-38.
2012: Norio Sakai; Kazuyori Shimamura; Kosuke Tamura; Reiko Ikeda; Takeo Konakahara
Copper-catalyzed [5+1] annulation of 2-ethynylanilines with an N,O-acetal leading to construction of quinoline derivatives.
Organic letters 2012;14(3):836-9.
2011: Toshiaki Sasada; Norio Sakai; Youichi Aoki; Reiko Ikeda; Takeo Konakahara
Synthesis of tri- or tetrasubstituted pyrimidine derivatives through the [5+1] annulation of enamidines with either N,N-dimethylformamide dialkyl acetals or orthoesters and their application in a ring transformation of pyrimidines to pyrido[2,3-d]pyrimidin-5-one derivatives.
Chemistry (Weinheim an der Bergstrasse, Germany) 2011;17(34):9385-94.
2011: Reiko Ikeda; Masahiko Ikekita; Osamu Funatsu; Tadashi Kumakura; Masaki Kurosawa; Akinori Morita; Yumi Nakaike; Takazumi Okabayashi; Norio Sakai; Ayako Takei; Masamichi Yoshiwara; Takeo Konakahara
3-(3-Phenoxybenzyl)amino-β-carboline: a novel antitumor drug targeting α-tubulin.
Bioorganic & medicinal chemistry letters 2011;21(16):4784-7.
2011: Reiko Ikeda; Toshie Iwaki; Tomoko Iida; Takasumi Okabayashi; Eishiro Nishi; Masaki Kurosawa; Norio Sakai; Takeo Konakahara
3-benzylamino-β-carboline derivatives induce apoptosis through G2/M arrest in human carcinoma cells HeLa S-3.
European journal of medicinal chemistry 2011;46(2):636-46.
2010: Norio Sakai; Kazuyori Shimamura; Reiko Ikeda; Takeo Konakahara
Hf(OTf)4-catalyzed regioselective n-aminomethylation of indoles and related NH-containing heterocycles.
The Journal of organic chemistry 2010;75(11):3923-6.
2010: Norio Sakai; Kohji Fujii; Shinya Nabeshima; Reiko Ikeda; Takeo Konakahara
Highly selective conversion of nitrobenzenes using a simple reducing system combined with a trivalent indium salt and a hydrosilane.
Chemical communications (Cambridge, England) 2010;46(18):3173-5.
2010: Norio Sakai; Ryosuke Komatsu; Naoki Uchida; Reiko Ikeda; Takeo Konakahara
A single-step synthesis of enynes: Pd-catalyzed arylalkynylation of aryl iodides, internal alkynes, and alkynylsilanes.
Organic letters 2010;12(6):1300-3.
2009: Toshiaki Sasada; Fuminori Kobayashi; Norio Sakai; Takeo Konakahara
An unprecedented approach to 4,5-disubstituted pyrimidine derivatives by a ZnCl(2)-catalyzed three-component coupling reaction.
Organic letters 2009;11(10):2161-4.
2009: Munehisa Takahashi; Hiroshi Miyazaki; Mutsuo Furihata; Hirofumi Sakai; Takeo Konakahara; Morihiro Watanabe; Tomoko Okada
Chemokine CCL2/MCP-1 negatively regulates metastasis in a highly bone marrow-metastatic mouse breast cancer model.
Clinical & experimental metastasis 2009;26(7):817-28.
2008: Toshiaki Sasada; Norio Sakai; Takeo Konakahara
Me3SiCl-promoted three-component coupling reaction of a functionalized enamine, an acetal, and an alkyne: an unprecedented approach to the synthesis of tetrasubstituted pyridines via a [3 + 2 + 1] intermolecular cyclization.
The Journal of organic chemistry 2008;73(17):6905-8.
2008: Norio Sakai; Kimiyoshi Annaka; Akiko Fujita; Asuka Sato; Takeo Konakahara
InBr3-promoted divergent approach to polysubstituted indoles and quinolines from 2-ethynylanilines: switch from an intramolecular cyclization to an intermolecular dimerization by a type of terminal substituent group.
The Journal of organic chemistry 2008;73(11):4160-5.
2007: Norio Sakai; Toshimitsu Moriya; Takeo Konakahara
An efficient one-pot synthesis of unsymmetrical ethers: a directly reductive deoxygenation of esters using an InBr3/Et3SiH catalytic system.
The Journal of organic chemistry 2007;72(15):5920-2.
2007: Hiroyuki Suzuki; Norio Sakai; Ryohei Iwahara; Takayuki Fujiwaka; Mitsunobu Satoh; Akikazu Kakehi; Takeo Konakahara
Novel synthesis of 7-fluoro-8-(trifluoromethyl)- 1H-1,6-naphthyridin-4-one derivatives: intermolecular cyclization of an N-silyl-1-azaallyl anion with perfluoroalkene and subsequent intramolecular skeletal transformation of the resulting pentasubstituted pyridines.
The Journal of organic chemistry 2007;72(15):5878-81.
2006: Masatoshi Saiki; Takeo Konakahara; Hisayuki Morii
Interaction-based evaluation of the propensity for amyloid formation with cross-beta structure.
Biochemical and biophysical research communications 2006;343(4):1262-71.
2006: Norio Sakai; Kimiyoshi Annaka; Takeo Konakahara
Direct synthesis of polysubstituted quinoline derivatives by InBr3-promoted dimerization of 2-ethynylaniline derivatives.
The Journal of organic chemistry 2006;71(9):3653-5.
2006: Hisayuki Morii; Masatoshi Saiki; Takeo Konakahara; Miyuki Ishimura
Peripheral region for core cross-beta plays important role in amyloidogenicity.
Biochemical and biophysical research communications 2006;342(3):808-16.
2005: Nahoko Morii; Giyuu Kido; Takeo Konakahara; Hisayuki Morii
Molecular orientation of porphyrins accompanying the formation of chain-aligned DNA films.
Biomacromolecules 2005;6(6):3259-66.
2005: Norio Sakai; Youichi Aoki; Toshiaki Sasada; Takeo Konakahara
New approach to the practical synthesis of tri- or tetrasubstituted pyrimidine derivatives: a four-component coupling reaction from a functionalized silane, two types of aromatic nitriles, and acetals.
Organic letters 2005;7(21):4705-8.
2005: Nahoko Morii; Giyuu Kido; Takeo Konakahara; Hisayuki Morii
Orientation of dye molecules in DNA-based films with chain alignment and judgment of their DNA-binding modes.
The journal of physical chemistry. B 2005;109(32):15636-44.
2005: Masatoshi Saiki; Shinya Honda; Kazunori Kawasaki; Deshan Zhou; Akira Kaito; Takeo Konakahara; Hisayuki Morii
Higher-order molecular packing in amyloid-like fibrils constructed with linear arrangements of hydrophobic and hydrogen-bonding side-chains.
Journal of molecular biology 2005;348(4):983-98.
2005: S Inaba; T Okada; Takeo Konakahara; Masato Kodaka
Specific binding of amyloid-beta-protein to IMR-32 neuroblastoma cell membrane.
The journal of peptide research : official journal of the American Peptide Society 2005;65(5):485-90.
2005: Nahoko Morii; Giyuu Kido; Takeo Konakahara; Hisayuki Morii
Judgment for DNA-binding modes of dye molecules by novel chain-aligned film method.
Nucleic acids symposium series (2004) 2005;(49):197-8.
2004: Norio Sakai; Kimiyoshi Annaka; Takeo Konakahara
Palladium-catalyzed coupling reaction of terminal alkynes with aryl iodides in the presence of indium tribromide and its application to a one-pot synthesis of 2-phenylindole.
Organic letters 2004;6(10):1527-30.
2003: Ken-ichi Shinozaki; Takeo Konakahara; Hiroaki Okuno; Masato Kodaka
Analysis of fibril formation of amyloid-beta-protein by stretched exponential function.
Protein and peptide letters 2003;10(6):569-74.
2003: Norio Sakai; Maki Hirasawa; Toshihiro Hamajima; Takeo Konakahara
The aminomethylation of electron-rich aromatics with an N-silyl-N,O-acetal catalyzed by a metal triflate-TMSCl system: facile synthesis of aromatic primary amines, 1-aryl-trichloroethylamines.
The Journal of organic chemistry 2003;68(2):483-8.
2003: Shingo Akikusa; Ken-ichi Watanabe; E Horikawa; Kazuhiko Nakamura; Masato Kodaka; Hiroaki Okuno; Takeo Konakahara
Practical assay and molecular mechanism of aggregation inhibitors of beta-amyloid.
The journal of peptide research : official journal of the American Peptide Society 2003;61(1):1-6.
2002: Ken-ichi Watanabe; Kazuhiko Nakamura; Shingo Akikusa; Tomoko Okada; Masato Kodaka; Takeo Konakahara; Hiroaki Okuno
Inhibitors of fibril formation and cytotoxicity of beta-amyloid peptide composed of KLVFF recognition element and flexible hydrophilic disrupting element.
Biochemical and biophysical research communications 2002;290(1):121-4.
2001: Ken-ichi Watanabe; T Segawa; Kazuhiko Nakamura; Masato Kodaka; Takeo Konakahara; Hiroaki Okuno
Identification of the molecular interaction site of amyloid beta peptide by using a fluorescence assay.
The journal of peptide research : official journal of the American Peptide Society 2001;58(4):342-6.
2000: N Yagi; Yoshikatsu Ogawa; Masato Kodaka; T Okada; Takenori Tomohiro; Takeo Konakahara; Hiroaki Okuno
Preparation of functional liposomes with peptide ligands and their binding to cell membranes.
Lipids 2000;35(6):673-80.
1999: Yoshikatsu Ogawa; H Kawahara; N Yagi; Masato Kodaka; Takenori Tomohiro; T Okada; Takeo Konakahara; Hiroaki Okuno
Synthesis of a novel lipopeptide with alpha-melanocyte-stimulating hormone peptide ligand and its effect on liposome stability.
Lipids 1999;34(4):387-94.