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Kigen Kondo

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Atsushi Naganawa; Toshiaki Matsui; Masaki Ima; Koji Yoshida; Hiroshi Tsuruta; Shingo Yamamoto; Hiroshi Yamamoto; Hiroki Okada; Takayuki Maruyama; Hisao Nakai; Kigen Kondo; Masaaki Toda
Optimization of sulfonamide derivatives as highly selective EP1 receptor antagonists.
Atsushi Naganawa; Toshiaki Matsui; Tetsuji Saito; Masaki Ima; Tadashi Tatsumi; Shingo Yamamoto; Masayuki Murota; Hiroshi Yamamoto; Takayuki Maruyama; Shuichi Ohuchida; Hisao Nakai; Kigen Kondo; Masaaki Toda
Discovery of heteroaryl sulfonamides as new EP1 receptor selective antagonists.
Atsushi Naganawa; Tetsuji Saito; Yuuki Nagao; Hiromu Egashira; Maki Iwahashi; Tohru Kambe; Masatoshi Koketsu; Hiroshi Yamamoto; Michiyoshi Kobayashi; Takayuki Maruyama; Shuichi Ohuchida; Hisao Nakai; Kigen Kondo; Masaaki Toda
Discovery of new chemical leads for selective EP1 receptor antagonists.

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All Publications

2006: Atsushi Naganawa; Toshiaki Matsui; Masaki Ima; Koji Yoshida; Hiroshi Tsuruta; Shingo Yamamoto; Hiroshi Yamamoto; Hiroki Okada; Takayuki Maruyama; Hisao Nakai; Kigen Kondo; Masaaki Toda
Optimization of sulfonamide derivatives as highly selective EP1 receptor antagonists.
Bioorganic & medicinal chemistry 2006;14(23):7774-89.
2006: Atsushi Naganawa; Toshiaki Matsui; Tetsuji Saito; Masaki Ima; Tadashi Tatsumi; Shingo Yamamoto; Masayuki Murota; Hiroshi Yamamoto; Takayuki Maruyama; Shuichi Ohuchida; Hisao Nakai; Kigen Kondo; Masaaki Toda
Discovery of heteroaryl sulfonamides as new EP1 receptor selective antagonists.
Bioorganic & medicinal chemistry 2006;14(19):6628-39.
2006: Atsushi Naganawa; Tetsuji Saito; Yuuki Nagao; Hiromu Egashira; Maki Iwahashi; Tohru Kambe; Masatoshi Koketsu; Hiroshi Yamamoto; Michiyoshi Kobayashi; Takayuki Maruyama; Shuichi Ohuchida; Hisao Nakai; Kigen Kondo; Masaaki Toda
Discovery of new chemical leads for selective EP1 receptor antagonists.
Bioorganic & medicinal chemistry 2006;14(16):5562-77.
2002: Toru Maruyama; Shin-Itsu Kuwabe; Yasufumi Kawanaka; Tai Shiraishi; Yoshiyuki Shinagawa; Kiyoto Sakata; Akiteru Seki; Yoko Kishida; Hideyuki Yoshida; Takayuki Maruyama; Shuichi Ohuchida; Hisao Nakai; Shinsuke Hashimoto; Masanori Kawamura; Kigen Kondo; Masaaki Toda
Design and synthesis of a selective EP4-receptor agonist. Part 4: practical synthesis and biological evaluation of a novel highly selective EP4-receptor agonist.
Bioorganic & medicinal chemistry 2002;10(7):2103-10.
2002: Kousuke Tani; Atsushi Naganawa; Akiharu Ishida; Hiromu Egashira; Yoshihiko Odagaki; Toru Miyazaki; Tomoyuki Hasegawa; Yasufumi Kawanaka; Kenji Sagawa; Hiroyuki Harada; Mikio Ogawa; Takayuki Maruyama; Hisao Nakai; Shuichi Ohuchida; Kigen Kondo; Masaaki Toda
A practical synthesis and biological evaluation of 9-halogenated PGF analogues.
Bioorganic & medicinal chemistry 2002;10(6):1883-94.
2002: Toru Maruyama; Masaki Asada; Tai Shiraishi; Hideyuki Yoshida; Takayuki Maruyama; Shuichi Ohuchida; Hisao Nakai; Kigen Kondo; Masaaki Toda
Design and synthesis of a selective EP4-receptor agonist. Part 3: 16-phenyl-5-thiaPGE(1) and 9-beta-halo derivatives with improved stability.
Bioorganic & medicinal chemistry 2002;10(6):1743-59.
2002: Keiji Yoshida; Hiroji Oida; Takuya Kobayashi; Takayuki Maruyama; Masaharu Tanaka; Teruaki Katayama; Kojiro Yamaguchi; Eri Segi; Tadao Tsuboyama; Mutsumi Matsushita; Kosei Ito; Yoshiaki Ito; Yukihiko Sugimoto; Fumitaka Ushikubi; Shuichi Ohuchida; Kigen Kondo; Takashi Nakamura; Shuh Narumiya
Stimulation of bone formation and prevention of bone loss by prostaglandin E EP4 receptor activation.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(7):4580-5.
2002: Kousuke Tani; Atsushi Naganawa; Akiharu Ishida; Hiromu Egashira; Kenji Sagawa; Hiroyuki Harada; Mikio Ogawa; Takayuki Maruyama; Shuichi Ohuchida; Hisao Nakai; Kigen Kondo; Masaaki Toda
Development of a highly selective EP2-receptor agonist. Part 2: identification of 16-hydroxy-17,17-trimethylene 9beta-chloro PGF derivatives.
Bioorganic & medicinal chemistry 2002;10(4):1107-14.
2002: Kousuke Tani; Atsushi Naganawa; Akiharu Ishida; Kenji Sagawa; Hiroyuki Harada; Mikio Ogawa; Takayuki Maruyama; Shuichi Ohuchida; Hisao Nakai; Kigen Kondo; Masaaki Toda
Development of a highly selective EP2-receptor agonist. Part 1: identification of 16-hydroxy-17,17-trimethylene PGE2 derivatives.
Bioorganic & medicinal chemistry 2002;10(4):1093-106.
2002: Toru Maruyama; Masaki Asada; Tai Shiraishi; Akiharu Ishida; Hideyuki Yoshida; Takayuki Maruyama; Shuichi Ohuchida; Hisao Nakai; Kigen Kondo; Masaaki Toda
Design and synthesis of a selective EP4-receptor agonist. Part 2: 3,7-dithiaPGE1 derivatives with high selectivity.
Bioorganic & medicinal chemistry 2002;10(4):989-1008.
2002: Toru Maruyama; Masaki Asada; Tai Shiraishi; Hiromu Egashira; Hideyuki Yoshida; Takayuki Maruyama; Shuichi Ohuchida; Hisao Nakai; Kigen Kondo; Masaaki Toda
Design and synthesis of a selective EP4-receptor agonist. Part 1: discovery of 3,7-dithiaPGE1 derivatives and identification of their omega chains.
Bioorganic & medicinal chemistry 2002;10(4):975-88.
2001: Toshihiko Kawamori; Naoaki Uchiya; Seiichi Nakatsugi; Kouji Watanabe; Shuichi Ohuchida; Hiroshi Yamamoto; Takayuki Maruyama; Kigen Kondo; Takashi Sugimura; Keiji Wakabayashi
Chemopreventive effects of ONO-8711, a selective prostaglandin E receptor EP(1) antagonist, on breast cancer development.
Carcinogenesis 2001;22(12):2001-4.
2001: Takayuki Maruyama; Masaki Asada; Tai Shiraishi; K Sakata; A Seki; Hideyuki Yoshida; Y Shinagawa; T Maruyama; Shuichi Ohuchida; Hisao Nakai; Kigen Kondo; Masaaki Toda
Design and synthesis of a highly selective EP4-receptor agonist. Part 2: 5-thia and 9beta-haloPG derivatives with improved stability.
Bioorganic & medicinal chemistry letters 2001;11(15):2033-5.
2001: Takayuki Maruyama; Masaki Asada; Tai Shiraishi; Akiharu Ishida; Hiromu Egashira; Hideyuki Yoshida; T Maruyama; Shuichi Ohuchida; Hisao Nakai; Kigen Kondo; Masaaki Toda
Design and synthesis of a highly selective EP4-receptor agonist. Part 1: 3,7-dithiaPG derivatives with high selectivity.
Bioorganic & medicinal chemistry letters 2001;11(15):2029-31.
2001: Kousuke Tani; Atsushi Naganawa; Akiharu Ishida; Hiromu Egashira; Kenji Sagawa; Hiroyuki Harada; Mikio Ogawa; Takayuki Maruyama; Shuichi Ohuchida; Hisao Nakai; Kigen Kondo; Masaaki Toda
Design and synthesis of a highly selective EP2-receptor agonist.
Bioorganic & medicinal chemistry letters 2001;11(15):2025-8.
2000: Kouji Watanabe; Toshihiko Kawamori; Seiichi Nakatsugi; Toshihisa Ohta; Shuichi Ohuchida; Hiroshi Yamamoto; Takayuki Maruyama; Kigen Kondo; Shuh Narumiya; Takashi Sugimura; Keiji Wakabayashi
Inhibitory effect of a prostaglandin E receptor subtype EP(1) selective antagonist, ONO-8713, on development of azoxymethane-induced aberrant crypt foci in mice.
Cancer letters 2000;156(1):57-61.
1999: Kouji Watanabe; Toshihiko Kawamori; Seiichi Nakatsugi; Toshihisa Ohta; Shuichi Ohuchida; Hiroshi Yamamoto; Takayuki Maruyama; Kigen Kondo; Fumitaka Ushikubi; Shuh Narumiya; Takashi Sugimura; Keiji Wakabayashi
Role of the prostaglandin E receptor subtype EP1 in colon carcinogenesis.
Cancer research 1999;59(20):5093-6.