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Sudha Kondraganti

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Chemicals & Drugs

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Gene Expression Profiling

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Weiwu Jiang; Lihua Wang; Sudha R Kondraganti; Inayat S Fazili; Xanthi I Couroucli; Edward A Felix; Bhagavatula Moorthy
Disruption of the gene for CYP1A2, which is expressed primarily in liver, leads to differential regulation of hepatic and pulmonary mouse CYP1A1 expression and augmented human CYP1A1 transcriptional activation in response to 3-methylcholanthrene in vivo.
Sudha R Kondraganti; Weiwu Jiang; Anil K Jaiswal; Bhagavatula Moorthy
Persistent induction of hepatic and pulmonary phase II enzymes by 3-methylcholanthrene in rats.
Bhagavatula Moorthy; Kathirvel Muthiah; Inayat S Fazili; Sudha R Kondraganti; Lihua Wang; Xanthi I Couroucli; Weiwu Jiang
3-Methylcholanthrene elicits DNA adduct formation in the CYP1A1 promoter region and attenuates reporter gene expression in rat H4IIE cells.

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2010: Weiwu Jiang; Lihua Wang; Sudha R Kondraganti; Inayat S Fazili; Xanthi I Couroucli; Edward A Felix; Bhagavatula Moorthy
Disruption of the gene for CYP1A2, which is expressed primarily in liver, leads to differential regulation of hepatic and pulmonary mouse CYP1A1 expression and augmented human CYP1A1 transcriptional activation in response to 3-methylcholanthrene in vivo.
The Journal of pharmacology and experimental therapeutics 2010;335(2):369-79.
2008: Sudha R Kondraganti; Weiwu Jiang; Anil K Jaiswal; Bhagavatula Moorthy
Persistent induction of hepatic and pulmonary phase II enzymes by 3-methylcholanthrene in rats.
Toxicological sciences : an official journal of the Society of Toxicology 2008;102(2):337-44.
2007: Bhagavatula Moorthy; Kathirvel Muthiah; Inayat S Fazili; Sudha R Kondraganti; Lihua Wang; Xanthi I Couroucli; Weiwu Jiang
3-Methylcholanthrene elicits DNA adduct formation in the CYP1A1 promoter region and attenuates reporter gene expression in rat H4IIE cells.
Biochemical and biophysical research communications 2007;354(4):1071-7.
2005: Sudha R Kondraganti; Kathirvel Muthiah; Weiwu Jiang; Roberto Barrios; Bhagavatula Moorthy
Effects of 3-methylcholanthrene on gene expression profiling in the rat using cDNA microarray analyses.
Chemical research in toxicology 2005;18(11):1634-41.
2004: Weiwu Jiang; Stephen E Welty; Xanthi I Couroucli; Roberto Barrios; Sudha R Kondraganti; Kathirvel Muthiah; Ling Yu; Stephen E Avery; Bhagavatula Moorthy
Disruption of the Ah receptor gene alters the susceptibility of mice to oxygen-mediated regulation of pulmonary and hepatic cytochromes P4501A expression and exacerbates hyperoxic lung injury.
The Journal of pharmacology and experimental therapeutics 2004;310(2):512-9.
2003: Bhagavatula Moorthy; Kimberly P Miller; Weiwu Jiang; E Spencer Williams; Sudha R Kondraganti; Kenneth S Ramos
Role of cytochrome P4501B1 in benzo[a]pyrene bioactivation to DNA-binding metabolites in mouse vascular smooth muscle cells: evidence from 32P-postlabeling for formation of 3-hydroxybenzo[a]pyrene and benzo[a]pyrene-3,6-quinone as major proximate genotoxic intermediates.
The Journal of pharmacology and experimental therapeutics 2003;305(1):394-401.
2003: Sudha R Kondraganti; Pedro Fernandez-Salguero; Frank J Gonzalez; Kenneth S Ramos; Weiwu Jiang; Bhagavatula Moorthy
Polycyclic aromatic hydrocarbon-inducible DNA adducts: evidence by 32P-postlabeling and use of knockout mice for Ah receptor-independent mechanisms of metabolic activation in vivo.
International journal of cancer. Journal international du cancer 2003;103(1):5-11.
2002: Sudha R Kondraganti; Weiwu Jiang; Bhagavatula Moorthy
Differential regulation of expression of hepatic and pulmonary cytochrome P4501A enzymes by 3-methylcholanthrene in mice lacking the CYP1A2 gene.
The Journal of pharmacology and experimental therapeutics 2002;303(3):945-51.