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Lars Konermann

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Physiology

Protein Folding

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Publications

TOP 3
Amanda N Comeau; John F Corrigan; Chhatra B Khadka; JiangJiang Liu; Lars Konermann
Nanocluster isotope distributions measured by electrospray time-of-flight mass spectrometry.
Lars Konermann; Antony D Rodriguez; Elias Ahadi; Siavash Vahidi
Unraveling the mechanism of electrospray ionization.
Anil Khanal; Leonid S Brown; Yan Pan; Lars Konermann
Pulsed hydrogen/deuterium exchange mass spectrometry for time-resolved membrane protein folding studies.

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All Publications

2013: Amanda N Comeau; John F Corrigan; Chhatra B Khadka; JiangJiang Liu; Lars Konermann
Nanocluster isotope distributions measured by electrospray time-of-flight mass spectrometry.
Analytical chemistry 2013;85(2):1200-7.
2013: Lars Konermann; Antony D Rodriguez; Elias Ahadi; Siavash Vahidi
Unraveling the mechanism of electrospray ionization.
Analytical chemistry 2013;85(1):2-9.
2012: Anil Khanal; Leonid S Brown; Yan Pan; Lars Konermann
Pulsed hydrogen/deuterium exchange mass spectrometry for time-resolved membrane protein folding studies.
Journal of mass spectrometry : JMS 2012;47(12):1620-6.
2012: Lars Konermann; Yan Pan
Exploring membrane protein structural features by oxidative labeling and mass spectrometry.
Expert review of proteomics 2012;9(5):497-504.
2012: Jingxi Pan; Christoph H Borchers; Jun Han; Lars Konermann
Structure and dynamics of small soluble Aβ(1-40) oligomers studied by top-down hydrogen exchange mass spectrometry.
Biochemistry 2012;51(17):3694-703.
2012: Yan Pan; Xiang Ruan; Miguel A Valvano; Lars Konermann
Validation of membrane protein topology models by oxidative labeling and mass spectrometry.
Journal of the American Society for Mass Spectrometry 2012;23(5):889-98.
2012: Yan Pan; Hadeesha Piyadasa; Joe D O'Neil; Lars Konermann
Conformational dynamics of a membrane transport protein probed by H/D exchange and covalent labeling: the glycerol facilitator.
Journal of molecular biology 2012;416(3):400-13.
2012: Jingxi Pan; Brittany L Heath; Rebecca A Jockusch; Lars Konermann
Structural interrogation of electrosprayed peptide ions by gas-phase H/D exchange and electron capture dissociation mass spectrometry.
Analytical chemistry 2012;84(1):373-8.
2011: Stephen V Sciuto; Jiangjiang Liu; Lars Konermann
An electrostatic charge partitioning model for the dissociation of protein complexes in the gas phase.
Journal of the American Society for Mass Spectrometry 2011;22(10):1679-89.
2011: Lars Konermann; Yan Pan; Bradley B Stocks
Protein folding mechanisms studied by pulsed oxidative labeling and mass spectrometry.
Current opinion in structural biology 2011;21(5):634-40.
2011: Jingxi Pan; Christoph H Borchers; Jun Han; Lars Konermann
Conformer-specific hydrogen exchange analysis of Aβ(1-42) oligomers by top-down electron capture dissociation mass spectrometry.
Analytical chemistry 2011;83(13):5386-93.
2011: Yan Pan; Leonid Brown; Lars Konermann
Kinetic folding mechanism of an integral membrane protein examined by pulsed oxidative labeling and mass spectrometry.
Journal of molecular biology 2011;410(1):146-58.
2011: Elias Ahadi; Lars Konermann
Ejection of solvated ions from electrosprayed methanol/water nanodroplets studied by molecular dynamics simulations.
Journal of the American Chemical Society 2011;133(24):9354-63.
2011: Bradley B Stocks; Atoosa Rezvanpour; Gary Shaw; Lars Konermann
Temporal development of protein structure during S100A11 folding and dimerization probed by oxidative labeling and mass spectrometry.
Journal of molecular biology 2011;409(4):669-79.
2011: Jiangjiang Liu; Lars Konermann
Protein-protein binding affinities in solution determined by electrospray mass spectrometry.
Journal of the American Society for Mass Spectrometry 2011;22(3):408-17.
2011: Lars Konermann; Jingxi Pan; Yu-Hong Liu
Hydrogen exchange mass spectrometry for studying protein structure and dynamics.
Chemical Society reviews 2011;40(3):1224-34.
2010: Yan Pan; Leonid Brown; Lars Konermann
Site-directed mutagenesis combined with oxidative methionine labeling for probing structural transitions of a membrane protein by mass spectrometry.
Journal of the American Society for Mass Spectrometry 2010;21(11):1947-56.
2010: Jingxi Pan; Jun Han; Christoph H Borchers; Lars Konermann
Characterizing short-lived protein folding intermediates by top-down hydrogen exchange mass spectrometry.
Analytical chemistry 2010;82(20):8591-7.
2010: Elias Ahadi; Lars Konermann
Surface charge of electrosprayed water nanodroplets: a molecular dynamics study.
Journal of the American Chemical Society 2010;132(32):11270-7.
2010: Lars Konermann; Bradley B Stocks; Tomasz Czarny
Laminar flow effects during laser-induced oxidative labeling for protein structural studies by mass spectrometry.
Analytical chemistry 2010;82(15):6667-74.
2010: Lars Konermann; Bradley B Stocks; Yan Pan; Xin Tong
Mass spectrometry combined with oxidative labeling for exploring protein structure and folding.
Mass spectrometry reviews 2010;29(4):651-67.
2010: Yan Pan; Lars Konermann
Membrane protein structural insights from chemical labeling and mass spectrometry.
The Analyst 2010;135(6):1191-200.
2010: Bradley B Stocks; Lars Konermann
Time-dependent changes in side-chain solvent accessibility during cytochrome c folding probed by pulsed oxidative labeling and mass spectrometry.
Journal of molecular biology 2010;398(2):362-73.
2010: Jingxi Pan; Lars Konermann
Calcium-induced structural transitions of the calmodulin-melittin system studied by electrospray mass spectrometry: conformational subpopulations and metal-unsaturated intermediates.
Biochemistry 2010;49(16):3477-86.
2009: Yan Pan; Leonid Brown; Lars Konermann
Mapping the structure of an integral membrane protein under semi-denaturing conditions by laser-induced oxidative labeling and mass spectrometry.
Journal of molecular biology 2009;394(5):968-81.
2009: Jingxi Pan; Jun Han; Christoph H Borchers; Lars Konermann
Hydrogen/deuterium exchange mass spectrometry with top-down electron capture dissociation for characterizing structural transitions of a 17 kDa protein.
Journal of the American Chemical Society 2009;131(35):12801-8.
2009: Yu-Hong Liu; Antoaneta Belcheva; Lars Konermann; Dasantila Golemi-Kotra
Phosphorylation-induced activation of the response regulator VraR from Staphylococcus aureus: insights from hydrogen exchange mass spectrometry.
Journal of molecular biology 2009;391(1):149-63.
2009: Jingxi Pan; Kun Xu; Xiaoda Yang; Wing-Yiu Choy; Lars Konermann
Solution-phase chelators for suppressing nonspecific protein-metal interactions in electrospray mass spectrometry.
Analytical chemistry 2009;81(12):5008-15.
2009: Elias Ahadi; Lars Konermann
Molecular dynamics simulations of electrosprayed water nanodroplets: internal potential gradients, location of excess charge centers, and "hopping" protons.
The journal of physical chemistry. B 2009;113(20):7071-80.
2009: Brian L Boys; Mark C Kuprowski; James J Noël; Lars Konermann
Protein oxidative modifications during electrospray ionization: solution phase electrochemistry or corona discharge-induced radical attack?
Analytical chemistry 2009;81(10):4027-34.
2009: Jiangjiang Liu; Lars Konermann
Irreversible thermal denaturation of cytochrome C studied by electrospray mass spectrometry.
Journal of the American Society for Mass Spectrometry 2009;20(5):819-28.
2009: Nicole M Marlatt; Brian L Boys; Lars Konermann; Gary Shaw
Formation of monomeric S100B and S100A11 proteins at low ionic strength.
Biochemistry 2009;48(9):1954-63.
2009: Lars Konermann
A simple model for the disintegration of highly charged solvent droplets during electrospray ionization.
Journal of the American Society for Mass Spectrometry 2009;20(3):496-506.
2009: Bradley B Stocks; Lars Konermann
Structural characterization of short-lived protein unfolding intermediates by laser-induced oxidative labeling and mass spectrometry.
Analytical chemistry 2009;81(1):20-7.
2009: Yan Pan; Bradley B Stocks; Leonid Brown; Lars Konermann
Structural characterization of an integral membrane protein in its natural lipid environment by oxidative methionine labeling and mass spectrometry.
Analytical chemistry 2009;81(1):28-35.
2008: Jingxi Pan; Jun Han; Christoph H Borchers; Lars Konermann
Electron capture dissociation of electrosprayed protein ions for spatially resolved hydrogen exchange measurements.
Journal of the American Chemical Society 2008;130(35):11574-5.
2008: Lars Konermann; Xin Tong; Yan Pan
Protein structure and dynamics studied by mass spectrometry: H/D exchange, hydroxyl radical labeling, and related approaches.
Journal of mass spectrometry : JMS 2008;43(8):1021-36.
2008: Yu-Hong Liu; Lars Konermann
Conformational dynamics of free and catalytically active thermolysin are indistinguishable by hydrogen/deuterium exchange mass spectrometry.
Biochemistry 2008;47(24):6342-51.
2008: Peter L Ferguson; Lars Konermann
Nonuniform isotope patterns produced by collision-induced dissociation of homogeneously labeled ubiquitin: implications for spatially resolved hydrogen/deuterium exchange ESI-MS studies.
Analytical chemistry 2008;80(11):4078-86.
2008: Xin Tong; J Clara Wren; Lars Konermann
gamma-Ray-mediated oxidative labeling for detecting protein conformational changes by electrospray mass spectrometry.
Analytical chemistry 2008;80(6):2222-31.
2007: Shiluan Yi; Brian L Boys; Anne Brickenden; Lars Konermann; Wing-Yiu Choy
Effects of zinc binding on the structure and dynamics of the intrinsically disordered protein prothymosin alpha: evidence for metalation as an entropic switch.
Biochemistry 2007;46(45):13120-30.
2007: Brian L Boys; Mark C Kuprowski; Lars Konermann
Symmetric behavior of hemoglobin alpha- and beta- subunits during acid-induced denaturation observed by electrospray mass spectrometry.
Biochemistry 2007;46(37):10675-84.
2007: Xin Tong; J Clara Wren; Lars Konermann
Effects of protein concentration on the extent of gamma-ray-mediated oxidative labeling studied by electrospray mass spectrometry.
Analytical chemistry 2007;79(16):6376-82.
2007: Mark C Kuprowski; Brian L Boys; Lars Konermann
Analysis of protein mixtures by electrospray mass spectrometry: effects of conformation and desolvation behavior on the signal intensities of hemoglobin subunits.
Journal of the American Society for Mass Spectrometry 2007;18(7):1279-85.
2007: Lars Konermann
A minimalist model for exploring conformational effects on the electrospray charge state distribution of proteins.
The journal of physical chemistry. B 2007;111(23):6534-43.
2007: Mark C Kuprowski; Lars Konermann
Signal response of coexisting protein conformers in electrospray mass spectrometry.
Analytical chemistry 2007;79(6):2499-506.
2007: Peter L Ferguson; Jingxi Pan; Derek J Wilson; Brian R Dempsey; Gilles Lajoie; Brian H Shilton; Lars Konermann
Hydrogen/deuterium scrambling during quadrupole time-of-flight MS/MS analysis of a zinc-binding protein domain.
Analytical chemistry 2007;79(1):153-60.
2007: Brian L Boys; Lars Konermann
Folding and assembly of hemoglobin monitored by electrospray mass spectrometry using an on-line dialysis system.
Journal of the American Society for Mass Spectrometry 2007;18(1):8-16.
2006: Yu-Hong Liu; Lars Konermann
Enzyme conformational dynamics during catalysis and in the 'resting state' monitored by hydrogen/deuterium exchange mass spectrometry.
FEBS letters 2006;580(22):5137-42.
2006: Lars Konermann
Exploring the relationship between funneled energy landscapes and two-state protein folding.
Proteins 2006;65(1):153-63.
2006: Jingxi Pan; Anne C Rintala-Dempsey; Yu Li; Gary Shaw; Lars Konermann
Folding kinetics of the S100A11 protein dimer studied by time-resolved electrospray mass spectrometry and pulsed hydrogen-deuterium exchange.
Biochemistry 2006;45(9):3005-13.
2006: Belal M Hossain; Lars Konermann
Pulsed hydrogen/deuterium exchange MS/MS for studying the relationship between noncovalent protein complexes in solution and in the gas phase after electrospray ionization.
Analytical chemistry 2006;78(5):1613-9.
2006: Lars Konermann; Jingxi Pan; Derek J Wilson
Protein folding mechanisms studied by time-resolved electrospray mass spectrometry.
BioTechniques 2006;40(2):135, 137, 139 passim.
2005: Derek J Wilson; Lars Konermann
Ultrarapid desalting of protein solutions for electrospray mass spectrometry in a microchannel laminar flow device.
Analytical chemistry 2005;77(21):6887-94.
2005: Sonya M Schermann; Douglas A Simmons; Lars Konermann
Mass spectrometry-based approaches to protein-ligand interactions.
Expert review of proteomics 2005;2(4):475-85.
2005: Jingxi Pan; Derek J Wilson; Lars Konermann
Pulsed hydrogen exchange and electrospray charge-state distribution as complementary probes of protein structure in kinetic experiments: implications for ubiquitin folding.
Biochemistry 2005;44(24):8627-33.
2005: Derek J Wilson; Steven P Rafferty; Lars Konermann
Kinetic unfolding mechanism of the inducible nitric oxide synthase oxygenase domain determined by time-resolved electrospray mass spectrometry.
Biochemistry 2005;44(7):2276-83.
2005: Marcelo O Crespin; Brian L Boys; Lars Konermann
The reconstitution of unfolded myoglobin with hemin dicyanide is not accelerated by fly-casting.
FEBS letters 2005;579(1):271-4.
2004: Richard A Ochran; Lars Konermann
Effects of ground loop currents on signal intensities in electrospray mass spectrometry.
Journal of the American Society for Mass Spectrometry 2004;15(12):1748-54.
2004: Sonya M Clark; Lars Konermann
Determination of ligand-protein dissociation constants by electrospray mass spectrometry-based diffusion measurements.
Analytical chemistry 2004;76(23):7077-83.
2004: Douglas A Simmons; Derek J Wilson; Gilles Lajoie; Amanda Doherty-Kirby; Lars Konermann
Subunit disassembly and unfolding kinetics of hemoglobin studied by time-resolved electrospray mass spectrometry.
Biochemistry 2004;43(46):14792-801.
2004: Derek J Wilson; Lars Konermann
Mechanistic studies on enzymatic reactions by electrospray ionization MS using a capillary mixer with adjustable reaction chamber volume for time-resolved measurements.
Analytical chemistry 2004;76(9):2537-43.
2004: Sonya M Clark; Lars Konermann
Screening for noncovalent ligand-receptor interactions by electrospray ionization mass spectrometry-based diffusion measurements.
Analytical chemistry 2004;76(5):1257-63.
2003: Derek J Wilson; Lars Konermann
A capillary mixer with adjustable reaction chamber volume for millisecond time-resolved studies by electrospray mass spectrometry.
Analytical chemistry 2003;75(23):6408-14.
2003: Douglas A Simmons; Stanley D Dunn; Lars Konermann
Conformational dynamics of partially denatured myoglobin studied by time-resolved electrospray mass spectrometry with online hydrogen-deuterium exchange.
Biochemistry 2003;42(19):5896-905.
2003: Sonya M Clark; Lars Konermann
Diffusion measurements by electrospray mass spectrometry for studying solution-phase noncovalent interactions.
Journal of the American Society for Mass Spectrometry 2003;14(5):430-41.
2003: Lars Konermann; Douglas A Simmons
Protein-folding kinetics and mechanisms studied by pulse-labeling and mass spectrometry.
Mass spectrometry reviews 2003;22(1):1-26.
2002: Douglas A Simmons; Lars Konermann
Characterization of transient protein folding intermediates during myoglobin reconstitution by time-resolved electrospray mass spectrometry with on-line isotopic pulse labeling.
Biochemistry 2002;41(6):1906-14.
2002: Lars Konermann; Donald J Douglas
Pre-steady-state kinetics of enzymatic reactions studied by electrospray mass spectrometry with on-line rapid-mixing techniques.
Methods in enzymology 2002;354():50-64.
2002: Sonya M Clark; Derek G Leaist; Lars Konermann
Taylor dispersion monitored by electrospray mass spectrometry: a novel approach for studying diffusion in solution.
Rapid communications in mass spectrometry : RCM 2002;16(15):1454-62.
2001: Lars Konermann; E A Silva; O F Sogbein
Electrochemically induced pH changes resulting in protein unfolding in the ion source of an electrospray mass spectrometer.
Analytical chemistry 2001;73(20):4836-44.
2001: B M Kolakowski; Lars Konermann
From small-molecule reactions to protein folding: studying biochemical kinetics by stopped-flow electrospray mass spectrometry.
Analytical biochemistry 2001;292(1):107-14.
2000: O O Sogbein; Douglas A Simmons; Lars Konermann
Effects of pH on the kinetic reaction mechanism of myoglobin unfolding studied by time-resolved electrospray ionization mass spectrometry.
Journal of the American Society for Mass Spectrometry 2000;11(4):312-9.
2000: B M Kolakowski; Douglas A Simmons; Lars Konermann
Stopped-flow electrospray ionization mass spectrometry: a new method for studying chemical reaction kinetics in solution.
Rapid communications in mass spectrometry : RCM 2000;14(9):772-6.
1999: V W Lee; Y L Chen; Lars Konermann
Reconstitution of acid-denatured holomyoglobin studied by time-resolved electrospray ionization mass spectrometry.
Analytical chemistry 1999;71(19):4154-9.
1998: Lars Konermann; Donald J Douglas
Unfolding of proteins monitored by electrospray ionization mass spectrometry: a comparison of positive and negative ion modes.
Journal of the American Society for Mass Spectrometry 1998;9(12):1248-54.
1998: David L Zechel; Lars Konermann; Stephen G Withers; Donald J Douglas
Pre-steady state kinetic analysis of an enzymatic reaction monitored by time-resolved electrospray ionization mass spectrometry.
Biochemistry 1998;37(21):7664-9.
1998: Y L Chen; J M Campbell; BA Collings; Lars Konermann; Donald J Douglas
Stability of a highly charged noncovalent complex in the gas phase: holomyoglobin.
Rapid communications in mass spectrometry : RCM 1998;12(15):1003-10.
1998: Lars Konermann; Donald J Douglas
Equilibrium unfolding of proteins monitored by electrospray ionization mass spectrometry: distinguishing two-state from multi-state transitions.
Rapid communications in mass spectrometry : RCM 1998;12(8):435-42.
1997: Lars Konermann; Donald J Douglas
Acid-induced unfolding of cytochrome c at different methanol concentrations: electrospray ionization mass spectrometry specifically monitors changes in the tertiary structure.
Biochemistry 1997;36(40):12296-302.
1997: Lars Konermann; Federico I Rosell; A Grant Mauk; Donald J Douglas
Acid-induced denaturation of myoglobin studied by time-resolved electrospray ionization mass spectrometry.
Biochemistry 1997;36(21):6448-54.
1997: Lars Konermann; BA Collings; Donald J Douglas
Cytochrome c folding kinetics studied by time-resolved electrospray ionization mass spectrometry.
Biochemistry 1997;36(18):5554-9.