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Ah-Ng Tony Kong

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Longqin Hu; Daigo Inoyama; John E Kerrigan; Carol Khodier; Ah-Ng Tony Kong; Timothy A Lewis; Sadagopan Magesh; Lesa J Beamer; Lin Chen; Yu Chen; Sivaraman Dandapani; Thomas J Emge; Michelle Palmer; Stuart L Schreiber; Jian Shen; Lili Wang; Benito Munoz
Discovery of a small-molecule inhibitor and cellular probe of Keap1-Nrf2 protein-protein interaction.
Chengyue Zhang; Tin Oo Khor; Limin Shu; Zheng-Yuan Su; Ah-Ng Tony Kong
Sulforaphane enhances Nrf2 expression in prostate cancer TRAMP C1 cells through epigenetic regulation.
Zheng-Yuan Su; Nanjoo Suh; Qing Wu; Tien-Yuan Wu; Chung S Yang; Allan H Conney; Ying Huang; Tin Oo Khor; Jong Hun Lee; Constance Lay-Lay Saw; Limin Shu; Ah-Ng Tony Kong
Epigenetic reactivation of Nrf2 in murine prostate cancer TRAMP C1 cells by natural phytochemicals Z-ligustilide and Radix angelica sinensis via promoter CpG demethylation.

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2013: Longqin Hu; Daigo Inoyama; John E Kerrigan; Carol Khodier; Ah-Ng Tony Kong; Timothy A Lewis; Sadagopan Magesh; Lesa J Beamer; Lin Chen; Yu Chen; Sivaraman Dandapani; Thomas J Emge; Michelle Palmer; Stuart L Schreiber; Jian Shen; Lili Wang; Benito Munoz
Discovery of a small-molecule inhibitor and cellular probe of Keap1-Nrf2 protein-protein interaction.
Bioorganic & medicinal chemistry letters 2013;23(10):3039-43.
2013: Chengyue Zhang; Tin Oo Khor; Limin Shu; Zheng-Yuan Su; Ah-Ng Tony Kong
Sulforaphane enhances Nrf2 expression in prostate cancer TRAMP C1 cells through epigenetic regulation.
Biochemical pharmacology 2013;85(9):1398-404.
2013: Zheng-Yuan Su; Nanjoo Suh; Qing Wu; Tien-Yuan Wu; Chung S Yang; Allan H Conney; Ying Huang; Tin Oo Khor; Jong Hun Lee; Constance Lay-Lay Saw; Limin Shu; Ah-Ng Tony Kong
Epigenetic reactivation of Nrf2 in murine prostate cancer TRAMP C1 cells by natural phytochemicals Z-ligustilide and Radix angelica sinensis via promoter CpG demethylation.
Chemical research in toxicology 2013;26(3):477-85.
2013: Jong Hun Lee; Limin Shu; Zheng-Yuan Su; Francisco Fuentes; Tin Oo Khor; Ah-Ng Tony Kong
Dietary phytochemicals and cancer prevention: Nrf2 signaling, epigenetics, and cell death mechanisms in blocking cancer initiation and progression.
Pharmacology & therapeutics 2013;137(2):153-71.
2013: J-H Kim; J D Chen; Siwang Yu; Ah-Ng Tony Kong
The nuclear cofactor RAC3/AIB1/SRC-3 enhances Nrf2 signaling by interacting with transactivation domains.
Oncogene 2013;32(4):514-27.
2013: Spyros K Stamatelos; Ah-Ng Tony Kong; Ioannis Androulakis; Panos G Georgopoulos
A semi-mechanistic integrated toxicokinetic-toxicodynamic (TK/TD) model for arsenic(III) in hepatocytes.
Journal of theoretical biology 2013;317():244-56.
2013: Zheng-Yuan Su; Francisco Fuentes; Tin Oo Khor; Jong Hun Lee; Limin Shu; Ah-Ng Tony Kong
A perspective on dietary phytochemicals and cancer chemoprevention: oxidative stress, nrf2, and epigenomics.
Topics in current chemistry 2013;329():133-62.
2012: Hu Wang; Francisco Fuentes; Tin Oo Khor; Jong-Hun Lee; Limin Shu; Zheng-Yuan Su; Ah-Ng Tony Kong
Plants vs. cancer: a review on natural phytochemicals in preventing and treating cancers and their druggability.
Anti-cancer agents in medicinal chemistry 2012;12(10):1281-305.
2012: Amanda K Smolarek; Jae Young So; Chung S Yang; Brenda Burgess; Yu-Kuo Chen; Ah-Ng Tony Kong; Mao-Jung Lee; Guangxun Li; Yong Lin; Kenneth R Reuhl; Weichung Joe Shih; Nanjoo Suh
Dietary administration of δ- and γ-tocopherol inhibits tumorigenesis in the animal model of estrogen receptor-positive, but not HER-2 breast cancer.
Cancer prevention research (Philadelphia, Pa.) 2012;5(11):1310-20.
2012: Hu Wang; Tien-Yuan Wu; Qian Yang; Wen Lin; Constance Lay-Lay Saw; Ioannis P Androulakis; Ying Huang; Tin Oo Khor; Ah-Ng Tony Kong
Pharmacokinetics and pharmacodynamics of phase II drug metabolizing/antioxidant enzymes gene response by anticancer agent sulforaphane in rat lymphocytes.
Molecular pharmaceutics 2012;9(10):2819-27.
2012: Constance Lay Lay Saw; Zheng-Yuan Su; Jingrong Wang; Anne Yuqing Yang; Sarandeep S-S Boyanapalli; David C Cheng; Song Gao; Zhi-Hong Jiang; Tin Oo Khor; Ah-Ng Tony Kong
Pharmacodynamics of ginsenosides: antioxidant activities, activation of Nrf2, and potential synergistic effects of combinations.
Chemical research in toxicology 2012;25(8):1574-80.
2012: Hongxia Lin; Joseph R Bertino; Robert S DiPaola; Murugesan K Gounder; Ah-Ng Tony Kong; Mark N Stein
A validated HPLC assay for the determination of R-(-)-gossypol in human plasma and its application in clinical pharmacokinetic studies.
Journal of pharmaceutical and biomedical analysis 2012;66():371-5.
2012: Dina Gifkins; Ah-Ng Tony Kong; Shou-En Lu; Sara H Olson; Kitaw Demissie; Elisa Bandera
Total and individual antioxidant intake and endometrial cancer risk: results from a population-based case-control study in New Jersey.
Cancer causes & control : CCC 2012;23(6):887-95.
2012: Kate Petersen Shay; Ah-Ng Tony Kong; Wenge Li; Alexander J Michels; Tory M Hagen
Cap-independent Nrf2 translation is part of a lipoic acid-stimulated detoxification stress response.
Biochimica et biophysica acta 2012;1823(6):1102-9.
2012: Chung S Yang; Nanjoo Suh; Ah-Ng Tony Kong
Does vitamin E prevent or promote cancer?
Cancer prevention research (Philadelphia, Pa.) 2012;5(5):701-5.
2012: Ying Huang; Tin Oo Khor; Constance Lay-Lay Saw; Limin Shu; Nanjoo Suh; Tien-Yuan Wu; Chung S Yang; Ah-Ng Tony Kong
A γ-tocopherol-rich mixture of tocopherols maintains Nrf2 expression in prostate tumors of TRAMP mice via epigenetic inhibition of CpG methylation.
The Journal of nutrition 2012;142(5):818-23.
2012: Murugesan K Gounder; Ah-Ng Tony Kong; Hongxia Lin; Mark Stein; Joseph R Bertino; Susan Goodin; Robert S DiPaola
A validated bioanalytical HPLC method for pharmacokinetic evaluation of 2-deoxyglucose in human plasma.
Biomedical chromatography : BMC 2012;26(5):650-4.
2012: Jianglin Ma; Monal Mehta; Bijan Sobhian; Tongde Wu; Allen Alcivar; Hong Cai; Ka Lung Cheung; Shridar Ganesan; Yanying Huo; Ah-Ng Tony Kong; Donna D Zhang; Bing Xia
PALB2 interacts with KEAP1 to promote NRF2 nuclear accumulation and function.
Molecular and cellular biology 2012;32(8):1506-17.
2012: Daigo Inoyama; Ah-Ng Tony Kong; Lesa J Beamer; Yu Chen; Xinyi Huang; Longqin Hu
Optimization of fluorescently labeled Nrf2 peptide probes and the development of a fluorescence polarization assay for the discovery of inhibitors of Keap1-Nrf2 interaction.
Journal of biomolecular screening 2012;17(4):435-47.
2012: Ying Huang; Wenge Li; Ah-Ng Tony Kong
Anti-oxidative stress regulator NF-E2-related factor 2 mediates the adaptive induction of antioxidant and detoxifying enzymes by lipid peroxidation metabolite 4-hydroxynonenal.
Cell & bioscience 2012;2(1):40.
2012: Dina Gifkins; Melony King; Ah-Ng Tony Kong; Shou-En Lu; Sara H Olson; Lisa Paddock; Lorna Rodriguez-Rodriguez; Kitaw Demissie; Elisa Bandera
Total and individual antioxidant intake and risk of epithelial ovarian cancer.
BMC cancer 2012;12():211.
2011: Limin Shu; Tien-Yuan Wu; Jong-Hun Lee; Constance L-L Saw; Sarandeep S S Boyanapalli; Ka-Lung Cheung; Ying Huang; Tin Oo Khor; Ah-Ng Tony Kong
Epigenetic CpG demethylation of the promoter and reactivation of the expression of Neurog1 by curcumin in prostate LNCaP cells.
The AAPS journal 2011;13(4):606-14.
2011: Yu Chen; Daigo Inoyama; Ah-Ng Tony Kong; Lesa J Beamer; Longqin Hu
Kinetic analyses of Keap1-Nrf2 interaction and determination of the minimal Nrf2 peptide sequence required for Keap1 binding using surface plasmon resonance.
Chemical biology & drug design 2011;78(6):1014-21.
2011: Tin Oo Khor; Jonghun Lee; Limin Shu; Tien-Yuan Wu; Ying Huang; Ah-Ng Tony Kong
Pharmacodynamics of curcumin as DNA hypomethylation agent in restoring the expression of Nrf2 via promoter CpGs demethylation.
Biochemical pharmacology 2011;82(9):1073-8.
2011: Constance Lay-Lay Saw; Tien-Yuan Wu; Melvilí Cintrón; Yue Guo; Ying Huang; Woo-Sik Jeong; Ah-Ng Tony Kong
Pharmacodynamics of dietary phytochemical indoles I3C and DIM: Induction of Nrf2-mediated phase II drug metabolizing and antioxidant genes and synergism with isothiocyanates.
Biopharmaceutics & drug disposition 2011;32(5):289-300.
2011: Ka Lung Cheung; Siwang Yu; Zui Pan; Jianjie Ma; Tien Yuan Wu; Ah-Ng Tony Kong
tBHQ-induced HO-1 expression is mediated by calcium through regulation of Nrf2 binding to enhancer and polymerase II to promoter region of HO-1.
Chemical research in toxicology 2011;24(5):670-6.
2011: Hyo Jung Kim; eric di Luccio; Ah-Ng Tony Kong; Jong-Sang Kim
Nrf2-mediated induction of phase 2 detoxifying enzymes by glyceollins derived from soybean exposed to Aspergillus sojae.
Biotechnology journal 2011;6(5):525-36.
2011: Constance Lay Lay Saw; Ah-Ng Tony Kong
Nuclear factor-erythroid 2-related factor 2 as a chemopreventive target in colorectal cancer.
Expert opinion on therapeutic targets 2011;15(3):281-95.
2011: Tien-Yuan Wu; Tin Oo Khor; Constance Lay Lay Saw; Stephanie C Loh; Alvin I Chen; Soon Sung Lim; Jung Han Yoon Park; Li Cai; Ah-Ng Tony Kong
Anti-inflammatory/Anti-oxidative stress activities and differential regulation of Nrf2-mediated genes by non-polar fractions of tea Chrysanthemum zawadskii and licorice Glycyrrhiza uralensis.
The AAPS journal 2011;13(1):1-13.
2011: Constance Lay Lay Saw; Tien-Yuan Wu; Tin Oo Khor; Ximena Paredes-Gonzalez; Douglas Pung; Ah-Ng Tony Kong
Pharmacodynamics of fish oil: protective effects against prostate cancer in TRAMP mice fed with a high fat western diet.
Asian Pacific journal of cancer prevention : APJCP 2011;12(12):3331-4.
2010: Hu Wang; Tin Oo Khor; Constance Lay Lay Saw; Wen Lin; Tienyuan Wu; Ying Huang; Ah-Ng Tony Kong
Role of Nrf2 in suppressing LPS-induced inflammation in mouse peritoneal macrophages by polyunsaturated fatty acids docosahexaenoic acid and eicosapentaenoic acid.
Molecular pharmaceutics 2010;7(6):2185-93.
2010: Rong Hu; Constance Lay-Lay Saw; Rong Yu; Ah-Ng Tony Kong
Regulation of NF-E2-related factor 2 signaling for cancer chemoprevention: antioxidant coupled with antiinflammatory.
Antioxidants & redox signaling 2010;13(11):1679-98.
2010: Ka Lung Cheung; Tin Oo Khor; Mou-Tuan Huang; Ah-Ng Tony Kong
Differential in vivo mechanism of chemoprevention of tumor formation in azoxymethane/dextran sodium sulfate mice by PEITC and DBM.
Carcinogenesis 2010;31(5):880-5.
2010: Ka Lung Cheung; Ah-Ng Tony Kong
Molecular targets of dietary phenethyl isothiocyanate and sulforaphane for cancer chemoprevention.
The AAPS journal 2010;12(1):87-97.
2010: Constance Lay Lay Saw; Ying Huang; Ah-Ng Tony Kong
Synergistic anti-inflammatory effects of low doses of curcumin in combination with polyunsaturated fatty acids: docosahexaenoic acid or eicosapentaenoic acid.
Biochemical pharmacology 2010;79(3):421-30.
2010: Constance Lay-Lay Saw; Qing Wu; Ah-Ng Tony Kong
Anti-cancer and potential chemopreventive actions of ginseng by activating Nrf2 (NFE2L2) anti-oxidative stress/anti-inflammatory pathways.
Chinese medicine 2010;5():37.
2010: Avantika Barve; Tin Oo Khor; Kenneth R Reuhl; Bandaru Reddy; Harold L Newmark; Ah-Ng Tony Kong
Mixed tocotrienols inhibit prostate carcinogenesis in TRAMP mice.
Nutrition and cancer 2010;62(6):789-94.
2009: Guoxiang Shen; Ah-Ng Tony Kong
Nrf2 plays an important role in coordinated regulation of Phase II drug metabolism enzymes and Phase III drug transporters.
Biopharmaceutics & drug disposition 2009;30(7):345-55.
2009: Avantika Barve; Chi Chen; Vidya Hebbar; Joseph Desiderio; Constance Lay-Lay Saw; Ah-Ng Tony Kong
Metabolism, oral bioavailability and pharmacokinetics of chemopreventive kaempferol in rats.
Biopharmaceutics & drug disposition 2009;30(7):356-65.
2009: Young-Sam Keum; Tin Oo Khor; Wen Lin; Guoxiang Shen; Ki Han Kwon; Avantika Barve; Wenge Li; Ah-Ng Tony Kong
Pharmacokinetics and pharmacodynamics of broccoli sprouts on the suppression of prostate cancer in transgenic adenocarcinoma of mouse prostate (TRAMP) mice: implication of induction of Nrf2, HO-1 and apoptosis and the suppression of Akt-dependent kinase pathway.
Pharmaceutical research 2009;26(10):2324-31.
2009: Tin Oo Khor; Siwang Yu; Avanthika Barve; Xingpei Hao; Jin-Liern Hong; Wen Lin; Barbara Foster; Mou-Tuan Huang; Harold L Newmark; Ah-Ng Tony Kong
Dietary feeding of dibenzoylmethane inhibits prostate cancer in transgenic adenocarcinoma of the mouse prostate model.
Cancer research 2009;69(17):7096-102.
2009: Auemduan Prawan; Constance Lay Lay Saw; Tin Oo Khor; Young-Sam Keum; Siwang Yu; Longqin Hu; Ah-Ng Tony Kong
Anti-NF-kappaB and anti-inflammatory activities of synthetic isothiocyanates: effect of chemical structures and cellular signaling.
Chemico-biological interactions 2009;179(2-3):202-11.
2009: Avantika Barve; Tin Oo Khor; Sujit Nair; Kenneth R Reuhl; Nanjoo Suh; Bandaru Reddy; Harold Newmark; Ah-Ng Tony Kong
Gamma-tocopherol-enriched mixed tocopherol diet inhibits prostate carcinogenesis in TRAMP mice.
International journal of cancer. Journal international du cancer 2009;124(7):1693-9.
2009: Wenge Li; Ah-Ng Tony Kong
Molecular mechanisms of Nrf2-mediated antioxidant response.
Molecular carcinogenesis 2009;48(2):91-104.
2008: Wenge Li; Tin Oo Khor; Changjiang Xu; Guoxiang Shen; Woo-Sik Jeong; Siwang Yu; Ah-Ng Tony Kong
Activation of Nrf2-antioxidant signaling attenuates NFkappaB-inflammatory response and elicits apoptosis.
Biochemical pharmacology 2008;76(11):1485-9.
2008: Wen Lin; Rachel T Wu; Tienyuan Wu; Tin Oo Khor; Hu Wang; Ah-Ng Tony Kong
Sulforaphane suppressed LPS-induced inflammation in mouse peritoneal macrophages through Nrf2 dependent pathway.
Biochemical pharmacology 2008;76(8):967-73.
2008: Tin Oo Khor; Siwang Yu; Ah-Ng Tony Kong
Dietary cancer chemopreventive agents - targeting inflammation and Nrf2 signaling pathway.
Planta medica 2008;74(13):1540-7.
2008: Wenge Li; Siwang Yu; Tong Liu; Jung-Hwan Kim; Volker Blank; Hong Li; Ah-Ng Tony Kong
Heterodimerization with small Maf proteins enhances nuclear retention of Nrf2 via masking the NESzip motif.
Biochimica et biophysica acta 2008;1783(10):1847-56.
2008: Avantika Barve; Tin Oo Khor; Sujit Nair; Wen Lin; Siwang Yu; MOHIT R JAIN; Jefferson Y Chan; Ah-Ng Tony Kong
Pharmacogenomic profile of soy isoflavone concentrate in the prostate of Nrf2 deficient and wild-type mice.
Journal of pharmaceutical sciences 2008;97(10):4528-45.
2008: Siwang Yu; Guoxiang Shen; Tin Oo Khor; Jung-Hwan Kim; Ah-Ng Tony Kong
Curcumin inhibits Akt/mammalian target of rapamycin signaling through protein phosphatase-dependent mechanism.
Molecular cancer therapeutics 2008;7(9):2609-20.
2008: Ah-Ng Tony Kong
Theme section on cancer chemoprevention.
Pharmaceutical research 2008;25(9):2094-6.
2008: Avantika Barve; Tin Oo Khor; Xingpei Hao; Young-Sam Keum; Chung S Yang; Bandaru Reddy; Ah-Ng Tony Kong
Murine prostate cancer inhibition by dietary phytochemicals--curcumin and phenyethylisothiocyanate.
Pharmaceutical research 2008;25(9):2181-9.
2008: Tin Oo Khor; Mou-Tuan Huang; Auemduan Prawan; Yue Liu; Xingpei Hao; Siwang Yu; William Ka Lung Cheung; Jefferson Y Chan; Bandaru S Reddy; Chung S Yang; Ah-Ng Tony Kong
Increased susceptibility of Nrf2 knockout mice to colitis-associated colorectal cancer.
Cancer prevention research (Philadelphia, Pa.) 2008;1(3):187-91.
2008: Ka Lung Cheung; Tin Oo Khor; Siwang Yu; Ah-Ng Tony Kong
PEITC induces G1 cell cycle arrest on HT-29 cells through the activation of p38 MAPK signaling pathway.
The AAPS journal 2008;10(2):277-81.
2008: Tin Oo Khor; William Ka Lung Cheung; Auemduan Prawan; Bandaru S Reddy; Ah-Ng Tony Kong
Chemoprevention of familial adenomatous polyposis in Apc(Min/+) mice by phenethyl isothiocyanate (PEITC).
Molecular carcinogenesis 2008;47(5):321-5.
2008: Gary J Van Berkel; Vilmos Kertesz; Kenneth A Koeplinger; marissa vavrek; Ah-Ng Tony Kong
Liquid microjunction surface sampling probe electrospray mass spectrometry for detection of drugs and metabolites in thin tissue sections.
Journal of mass spectrometry : JMS 2008;43(4):500-8.
2008: Auemduan Prawan; Young-Sam Keum; Tin Oo Khor; Siwang Yu; Sujit Nair; Wenge Li; Longqin Hu; Ah-Ng Tony Kong
Structural influence of isothiocyanates on the antioxidant response element (ARE)-mediated heme oxygenase-1 (HO-1) expression.
Pharmaceutical research 2008;25(4):836-44.
2008: Young-Sam Keum; Peter Pil-Jae Chang; Ki Han Kwon; Xiaoling Yuan; Wenge Li; Longqin Hu; Ah-Ng Tony Kong
3-Morpholinopropyl isothiocyanate is a novel synthetic isothiocyanate that strongly induces the antioxidant response element-dependent Nrf2-mediated detoxifying/antioxidant enzymes in vitro and in vivo.
Carcinogenesis 2008;29(3):594-9.
2008: Sujit Nair; Vidya Hebbar; Guoxiang Shen; Avantika Gopalakrishnan; Tin Oo Khor; Siwang Yu; Changjiang Xu; Ah-Ng Tony Kong
Synergistic effects of a combination of dietary factors sulforaphane and (-) epigallocatechin-3-gallate in HT-29 AP-1 human colon carcinoma cells.
Pharmaceutical research 2008;25(2):387-99.
2008: Xi Zheng; Richard L Chang; Xiao-Xing Cui; Gina E Avila; Mou-Tuan Huang; Yue Liu; Ah-Ng Tony Kong; Arnold B Rabson; Allan H Conney
Inhibition of NF-kappaB by (E)3-[(4-methylphenyl)-sulfonyl]-2-propenenitrile (BAY11-7082; BAY) is associated with enhanced 12-O-tetradecanoylphorbol-13-acetate-induced growth suppression and apoptosis in human prostate cancer PC-3 cells.
International journal of oncology 2008;32(1):257-64.
2007: Guoxiang Shen; Tin Oo Khor; Rong Hu; Siwang Yu; Sujit Nair; Chi-Tang Ho; Bandaru S Reddy; Mou-Tuan Huang; Harold L Newmark; Ah-Ng Tony Kong
Chemoprevention of familial adenomatous polyposis by natural dietary compounds sulforaphane and dibenzoylmethane alone and in combination in ApcMin/+ mouse.
Cancer research 2007;67(20):9937-44.
2007: Xi Zheng; Xiao-Xing Cui; Gina E Avila; Mou-Tuan Huang; Yue Liu; Jagruti Patel; Ah-Ng Tony Kong; Raphael Paulino; Weichung Joe Shih; Yong Lin; Arnold B Rabson; Bandaru S Reddy; Allan H Conney
Atorvastatin and celecoxib inhibit prostate PC-3 tumors in immunodeficient mice.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(18 Pt 1):5480-7.
2007: Ki Han Kwon; Avantika Barve; Siwang Yu; Mou-Tuan Huang; Ah-Ng Tony Kong
Cancer chemoprevention by phytochemicals: potential molecular targets, biomarkers and animal models.
Acta pharmacologica Sinica 2007;28(9):1409-21.
2007: Ah-Ng Tony Kong
Special issue on "molecular targets, biomarkers and animal models for anti-cancer pharmacological research: potentials and challenges from chemoprevention to chemotherapeutic treatment".
Acta pharmacologica Sinica 2007;28(9):1261.
2007: Siwang Yu; Ah-Ng Tony Kong
Targeting carcinogen metabolism by dietary cancer preventive compounds.
Current cancer drug targets 2007;7(5):416-24.
2007: Guoxiang Shen; Jin-Liern Hong; Ah-Ng Tony Kong
Development and validation of an HPLC method for the determination of dibenzoylmethane in rat plasma and its application to the pharmacokinetic study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2007;852(1-2):56-61.
2007: Sujit Nair; Wenge Li; Ah-Ng Tony Kong
Natural dietary anti-cancer chemopreventive compounds: redox-mediated differential signaling mechanisms in cytoprotection of normal cells versus cytotoxicity in tumor cells.
Acta pharmacologica Sinica 2007;28(4):459-72.
2007: Sujit Nair; Changjiang Xu; Guoxiang Shen; Vidya Hebbar; Avantika Gopalakrishnan; Rong Hu; MOHIT R JAIN; Celine Liew; Jefferson Y Chan; Ah-Ng Tony Kong
Toxicogenomics of endoplasmic reticulum stress inducer tunicamycin in the small intestine and liver of Nrf2 knockout and C57BL/6J mice.
Toxicology letters 2007;168(1):21-39.
2006: Tin Oo Khor; Mou-Tuan Huang; Ki Han Kwon; Jefferson Y Chan; Bandaru S Reddy; Ah-Ng Tony Kong
Nrf2-deficient mice have an increased susceptibility to dextran sulfate sodium-induced colitis.
Cancer research 2006;66(24):11580-4.
2006: Tin Oo Khor; Rong Hu; Guoxiang Shen; Woo-Sik Jeong; Vidya Hebbar; Chi Chen; Changjiang Xu; Sujit Nair; Bandaru Reddy; Kiran Chada; Ah-Ng Tony Kong
Pharmacogenomics of cancer chemopreventive isothiocyanate compound sulforaphane in the intestinal polyps of ApcMin/+ mice.
Biopharmaceutics & drug disposition 2006;27(9):407-20.
2006: Rong Hu; Changjiang Xu; Guoxiang Shen; MOHIT R JAIN; Tin Oo Khor; Avantika Gopalkrishnan; Wen Lin; Bandaru Reddy; Jefferson Y Chan; Ah-Ng Tony Kong
Gene expression profiles induced by cancer chemopreventive isothiocyanate sulforaphane in the liver of C57BL/6J mice and C57BL/6J/Nrf2 (-/-) mice.
Cancer letters 2006;243(2):170-92.
2006: Young-Sam Keum; Yong-Hee Han; Celine Liew; Jung-Hwan Kim; Changjiang Xu; Xiaoling Yuan; Michael P Shakarjian; Saeho Chong; Ah-Ng Tony Kong
Induction of heme oxygenase-1 (HO-1) and NAD[P]H: quinone oxidoreductase 1 (NQO1) by a phenolic antioxidant, butylated hydroxyanisole (BHA) and its metabolite, tert-butylhydroquinone (tBHQ) in primary-cultured human and rat hepatocytes.
Pharmaceutical research 2006;23(11):2586-94.
2006: Sujit Nair; Changjiang Xu; Guoxiang Shen; Vidya Hebbar; Avantika Gopalakrishnan; Rong Hu; MOHIT R JAIN; Wen Lin; Young-Sam Keum; Celine Liew; Jefferson Y Chan; Ah-Ng Tony Kong
Pharmacogenomics of phenolic antioxidant butylated hydroxyanisole (BHA) in the small intestine and liver of Nrf2 knockout and C57BL/6J mice.
Pharmaceutical research 2006;23(11):2621-37.
2006: Xiaoling Yuan; Changjiang Xu; Zui Pan; Young-Sam Keum; Jung-Hwan Kim; Guoxiang Shen; Siwang Yu; Khor Tin Oo; Jianjie Ma; Ah-Ng Tony Kong
Butylated hydroxyanisole regulates ARE-mediated gene expression via Nrf2 coupled with ERK and JNK signaling pathway in HepG2 cells.
Molecular carcinogenesis 2006;45(11):841-50.
2006: Rong Hu; Changjiang Xu; Guoxiang Shen; MOHIT R JAIN; Tin Oo Khor; Avantika Gopalkrishnan; Wen Lin; Bandaru Reddy; Jefferson Y Chan; Ah-Ng Tony Kong
Identification of Nrf2-regulated genes induced by chemopreventive isothiocyanate PEITC by oligonucleotide microarray.
Life sciences 2006;79(20):1944-55.
2006: Rong Hu; Guoxiang Shen; Usha Rao Yerramilli; Wen Lin; Changjiang Xu; Sujit Nair; Ah-Ng Tony Kong
In vivo pharmacokinetics, activation of MAPK signaling and induction of phase II/III drug metabolizing enzymes/transporters by cancer chemopreventive compound BHA in the mice.
Archives of pharmacal research 2006;29(10):911-20.
2006: Rong Hu; Tin Oo Khor; Guoxiang Shen; Woo-Sik Jeong; Vidya Hebbar; Chi Chen; Changjiang Xu; Bandaru Reddy; Kiran Chada; Ah-Ng Tony Kong
Cancer chemoprevention of intestinal polyposis in ApcMin/+ mice by sulforaphane, a natural product derived from cruciferous vegetable.
Carcinogenesis 2006;27(10):2038-46.
2006: Wenge Li; Si-Wang Yu; Ah-Ng Tony Kong
Nrf2 possesses a redox-sensitive nuclear exporting signal in the Neh5 transactivation domain.
The Journal of biological chemistry 2006;281(37):27251-63.
2006: Young-Sam Keum; Siwang Yu; Peter Pil-Jae Chang; Xiaoling Yuan; Jung-Hwan Kim; Changjiang Xu; Jiahuai Han; Anupam Agarwal; Ah-Ng Tony Kong
Mechanism of action of sulforaphane: inhibition of p38 mitogen-activated protein kinase isoforms contributing to the induction of antioxidant response element-mediated heme oxygenase-1 in human hepatoma HepG2 cells.
Cancer research 2006;66(17):8804-13.
2006: Changjiang Xu; Mou-Tuan Huang; Guoxiang Shen; Xiaoling Yuan; Wen Lin; Tin Oo Khor; Allan H Conney; Ah-Ng Tony Kong
Inhibition of 7,12-dimethylbenz(a)anthracene-induced skin tumorigenesis in C57BL/6 mice by sulforaphane is mediated by nuclear factor E2-related factor 2.
Cancer research 2006;66(16):8293-6.
2006: Avanthika Gopalakrishnan; Chang-Jiang Xu; Sujit Nair; Chi Chen; Vidya Hebbar; Ah-Ng Tony Kong
Modulation of activator protein-1 (AP-1) and MAPK pathway by flavonoids in human prostate cancer PC3 cells.
Archives of pharmacal research 2006;29(8):633-44.
2006: Changjiang Xu; Xiaoling Yuan; Zui Pan; Guoxiang Shen; Jung-Hwan Kim; Siwang Yu; Tin Oo Khor; Wenge Li; Jianjie Ma; Ah-Ng Tony Kong
Mechanism of action of isothiocyanates: the induction of ARE-regulated genes is associated with activation of ERK and JNK and the phosphorylation and nuclear translocation of Nrf2.
Molecular cancer therapeutics 2006;5(8):1918-26.
2006: Sandhya Mandlekar; Jin-Liern Hong; Ah-Ng Tony Kong
Modulation of metabolic enzymes by dietary phytochemicals: a review of mechanisms underlying beneficial versus unfavorable effects.
Current drug metabolism 2006;7(6):661-75.
2006: Tin Oo Khor; Sherif Ibrahim; Ah-Ng Tony Kong
Toxicogenomics in drug discovery and drug development: potential applications and future challenges.
Pharmaceutical research 2006;23(8):1659-64.
2006: Xi Zheng; Richard L Chang; Xiao-Xing Cui; Gina E Avila; Vidya Hebbar; Mark Garzotto; Weichung Joe Shih; Yong Lin; Shou-En Lu; Arnold B Rabson; Ah-Ng Tony Kong; Allan H Conney
Effects of 12-O-tetradecanoylphorbol-13-acetate (TPA) in combination with paclitaxel (Taxol) on prostate Cancer LNCaP cells cultured in vitro or grown as xenograft tumors in immunodeficient mice.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(11 Pt 1):3444-51.
2006: Wen Lin; Guoxiang Shen; Xiaoling Yuan; MOHIT R JAIN; Siwang Yu; Aihua Zhang; J Don Chen; Ah-Ng Tony Kong
Regulation of Nrf2 transactivation domain activity by p160 RAC3/SRC3 and other nuclear co-regulators.
Journal of biochemistry and molecular biology 2006;39(3):304-10.
2006: Bandaru S Reddy; Chung-Xiou Wang; Ah-Ng Tony Kong; Tin Oo Khor; Xi Zheng; Vernon E Steele; Levy Kopelovich; Chinthalapally V Rao
Prevention of azoxymethane-induced colon cancer by combination of low doses of atorvastatin, aspirin, and celecoxib in F 344 rats.
Cancer research 2006;66(8):4542-6.
2006: Jung-Hwan Kim; Changjiang Xu; Young-Sam Keum; Bandaru Reddy; Allan H Conney; Ah-Ng Tony Kong
Inhibition of EGFR signaling in human prostate cancer PC-3 cells by combination treatment with beta-phenylethyl isothiocyanate and curcumin.
Carcinogenesis 2006;27(3):475-82.
2006: Changjiang Xu; Guoxiang Shen; Xiaoling Yuan; Jung-Hwan Kim; Avantika Gopalkrishnan; Young-Sam Keum; Sujit Nair; Ah-Ng Tony Kong
ERK and JNK signaling pathways are involved in the regulation of activator protein 1 and cell death elicited by three isothiocyanates in human prostate cancer PC-3 cells.
Carcinogenesis 2006;27(3):437-45.
2006: Guoxiang Shen; Changjiang Xu; Chi Chen; Vidya Hebbar; Ah-Ng Tony Kong
p53-independent G1 cell cycle arrest of human colon carcinoma cells HT-29 by sulforaphane is associated with induction of p21CIP1 and inhibition of expression of cyclin D1.
Cancer chemotherapy and pharmacology 2006;57(3):317-27.
2006: Tin Oo Khor; Young-Sam Keum; Wen Lin; Jung-Hwan Kim; Rong Hu; Guoxiang Shen; Changjiang Xu; Avanthika Gopalakrishnan; Bandaru Reddy; Xi Zheng; Allan H Conney; Ah-Ng Tony Kong
Combined inhibitory effects of curcumin and phenethyl isothiocyanate on the growth of human PC-3 prostate xenografts in immunodeficient mice.
Cancer research 2006;66(2):613-21.
2006: Woo-Sik Jeong; Mira Jun; Ah-Ng Tony Kong
Nrf2: a potential molecular target for cancer chemoprevention by natural compounds.
Antioxidants & redox signaling 2006;8(1-2):99-106.
2006: Guoxiang Shen; Changjiang Xu; Rong Hu; MOHIT R JAIN; Avantika Gopalkrishnan; Sujit Nair; Mou-Tuan Huang; Jefferson Y Chan; Ah-Ng Tony Kong
Modulation of nuclear factor E2-related factor 2-mediated gene expression in mice liver and small intestine by cancer chemopreventive agent curcumin.
Molecular cancer therapeutics 2006;5(1):39-51.
2005: Guoxiang Shen; Woo-Sik Jeong; Rong Hu; Ah-Ng Tony Kong
Regulation of Nrf2, NF-kappaB, and AP-1 signaling pathways by chemopreventive agents.
Antioxidants & redox signaling 2005;7(11-12):1648-63.
2005: Guoxiang Shen; Changjiang Xu; Rong Hu; MOHIT R JAIN; Sujit Nair; Wen Lin; Chung S Yang; Jefferson Y Chan; Ah-Ng Tony Kong
Comparison of (-)-epigallocatechin-3-gallate elicited liver and small intestine gene expression profiles between C57BL/6J mice and C57BL/6J/Nrf2 (-/-) mice.
Pharmaceutical research 2005;22(11):1805-20.
2005: Young-Sam Keum; Woo-Sik Jeong; Ah-Ng Tony Kong
Chemopreventive functions of isothiocyanates.
Drug news & perspectives 2005;18(7):445-51.
2005: Wenge Li; MOHIT R JAIN; Chi Chen; Xin Yue; Vidya Hebbar; Renping Zhou; Ah-Ng Tony Kong
Nrf2 Possesses a redox-insensitive nuclear export signal overlapping with the leucine zipper motif.
The Journal of biological chemistry 2005;280(31):28430-8.
2005: Changjiang Xu; Guoxiang Shen; Chi Chen; Céline Gélinas; Ah-Ng Tony Kong
Suppression of NF-kappaB and NF-kappaB-regulated gene expression by sulforaphane and PEITC through IkappaBalpha, IKK pathway in human prostate cancer PC-3 cells.
Oncogene 2005;24(28):4486-95.
2005: Chi Chen; Ah-Ng Tony Kong
Dietary cancer-chemopreventive compounds: from signaling and gene expression to pharmacological effects.
Trends in pharmacological sciences 2005;26(6):318-26.
2005: Vidya Hebbar; Guoxiang Shen; Rong Hu; Bok-Ryang Kim; Chi Chen; Peter J Korytko; James A Crowell; Barry S Levine; Ah-Ng Tony Kong
Toxicogenomics of resveratrol in rat liver.
Life sciences 2005;76(20):2299-314.
2005: Woo-Sik Jeong; Young-Sam Keum; Chi Chen; MOHIT R JAIN; Guoxiang Shen; Jung-Hwan Kim; Wenge Li; Ah-Ng Tony Kong
Differential expression and stability of endogenous nuclear factor E2-related factor 2 (Nrf2) by natural chemopreventive compounds in HepG2 human hepatoma cells.
Journal of biochemistry and molecular biology 2005;38(2):167-76.
2005: Changjiang Xu; Christina Yong-Tao Li; Ah-Ng Tony Kong
Induction of phase I, II and III drug metabolism/transport by xenobiotics.
Archives of pharmacal research 2005;28(3):249-68.
2004: Chi Chen; Daniel Pung; Vasco Leong; Vidya Hebbar; Guoxiang Shen; Sujit Nair; Wenge Li; Ah-Ng Tony Kong
Induction of detoxifying enzymes by garlic organosulfur compounds through transcription factor Nrf2: effect of chemical structure and stress signals.
Free radical biology & medicine 2004;37(10):1578-90.
2004: Young-Sam Keum; Woo-Sik Jeong; Ah-Ng Tony Kong
Chemoprevention by isothiocyanates and their underlying molecular signaling mechanisms.
Mutation research 2004;555(1-2):191-202.
2004: Ah-Ng Tony Kong
Signal transduction in cancer chemoprevention.
Mutation research 2004;555(1-2):1-2.
2004: Rong Hu; Vidya Hebbar; Bok-Ryang Kim; Chi Chen; Bozena Winnik; Brian Buckley; Patricia Soteropoulos; Peter P Tolias; Ronald P Hart; Ah-Ng Tony Kong
In vivo pharmacokinetics and regulation of gene expression profiles by isothiocyanate sulforaphane in the rat.
The Journal of pharmacology and experimental therapeutics 2004;310(1):263-71.
2004: Chi Chen; Ah-Ng Tony Kong
Dietary chemopreventive compounds and ARE/EpRE signaling.
Free radical biology & medicine 2004;36(12):1505-16.
2004: Guoxiang Shen; Vidya Hebbar; Sujit Nair; Changjiang Xu; Wenge Li; Wen Lin; Young-Sam Keum; Jiahuai Han; Michael A Gallo; Ah-Ng Tony Kong
Regulation of Nrf2 transactivation domain activity. The differential effects of mitogen-activated protein kinase cascades and synergistic stimulatory effect of Raf and CREB-binding protein.
The Journal of biological chemistry 2004;279(22):23052-60.
2004: Woo-Sik Jeong; In-Wha Kim; Rong Hu; Ah-Ng Tony Kong
Modulatory properties of various natural chemopreventive agents on the activation of NF-kappaB signaling pathway.
Pharmaceutical research 2004;21(4):661-70.
2004: Woo-Sik Jeong; In-Wha Kim; Rong Hu; Ah-Ng Tony Kong
Modulation of AP-1 by natural chemopreventive compounds in human colon HT-29 cancer cell line.
Pharmaceutical research 2004;21(4):649-60.
2004: Rong Hu; Ah-Ng Tony Kong
Activation of MAP kinases, apoptosis and nutrigenomics of gene expression elicited by dietary cancer-prevention compounds.
Nutrition (Burbank, Los Angeles County, Calif.) 2004;20(1):83-8.
2003: Bok-Ryang Kim; Rong Hu; Young-Sam Keum; Vidya Hebbar; Guoxiang Shen; Sujit Nair; Ah-Ng Tony Kong
Effects of glutathione on antioxidant response element-mediated gene expression and apoptosis elicited by sulforaphane.
Cancer research 2003;63(21):7520-5.
2003: Young-Sam Keum; Edward D Owuor; Bok-Ryang Kim; Rong Hu; Ah-Ng Tony Kong
Involvement of Nrf2 and JNK1 in the activation of antioxidant responsive element (ARE) by chemopreventive agent phenethyl isothiocyanate (PEITC).
Pharmaceutical research 2003;20(9):1351-6.
2003: Rong Hu; Bok-Ryang Kim; Chi Chen; Vidya Hebbar; Ah-Ng Tony Kong
The roles of JNK and apoptotic signaling pathways in PEITC-mediated responses in human HT-29 colon adenocarcinoma cells.
Carcinogenesis 2003;24(8):1361-7.
2003: Chi Chen; Guoxiang Shen; Vidya Hebbar; Rong Hu; Edward D Owuor; Ah-Ng Tony Kong
Epigallocatechin-3-gallate-induced stress signals in HT-29 human colon adenocarcinoma cells.
Carcinogenesis 2003;24(8):1369-78.
2003: Zhi-Qiang Jiang; Chi Chen; Bo Yang; Vidya Hebbar; Ah-Ng Tony Kong
Differential responses from seven mammalian cell lines to the treatments of detoxifying enzyme inducers.
Life sciences 2003;72(20):2243-53.
2002: Parimal Misra; Edward D Owuor; Wenge Li; Songtao Yu; Chao Qi; Kirstin Meyer; Yi-Jun Zhu; M Sambasiva Rao; Ah-Ng Tony Kong; Janardan K Reddy
Phosphorylation of transcriptional coactivator peroxisome proliferator-activated receptor (PPAR)-binding protein (PBP). Stimulation of transcriptional regulation by mitogen-activated protein kinase.
The Journal of biological chemistry 2002;277(50):48745-54.
2002: Khew-Voon Chin; Ah-Ng Tony Kong
Application of DNA microarrays in pharmacogenomics and toxicogenomics.
Pharmaceutical research 2002;19(12):1773-8.
2002: Yi-Rong Chen; Jin Han; Rajashree Kori; Ah-Ng Tony Kong; Tse-Hua Tan
Phenylethyl isothiocyanate induces apoptotic signaling via suppressing phosphatase activity against c-Jun N-terminal kinase.
The Journal of biological chemistry 2002;277(42):39334-42.
2002: Thomas H Rushmore; Ah-Ng Tony Kong
Pharmacogenomics, regulation and signaling pathways of phase I and II drug metabolizing enzymes.
Current drug metabolism 2002;3(5):481-90.
2002: Edward D Owuor; Ah-Ng Tony Kong
Antioxidants and oxidants regulated signal transduction pathways.
Biochemical pharmacology 2002;64(5-6):765-70.
2001: Sandhya Mandlekar; Ah-Ng Tony Kong
Mechanisms of tamoxifen-induced apoptosis.
Apoptosis : an international journal on programmed cell death 2001;6(6):469-77.
2001: Ah-Ng Tony Kong; R Yu; Vidya Hebbar; Chin Chen; Edward D Owuor; Rong Hu; R Ee; Sandhya Mandlekar
Signal transduction events elicited by cancer prevention compounds.
Mutation research 2001;480-481():231-41.
2001: Ah-Ng Tony Kong; Edward D Owuor; R Yu; Vidya Hebbar; Chin Chen; Rong Hu; Sandhya Mandlekar
Induction of xenobiotic enzymes by the MAP kinase pathway and the antioxidant or electrophile response element (ARE/EpRE).
Drug metabolism reviews 2001;33(3-4):255-71.
2001: R Yu; Vidya Hebbar; D W Kim; Sandhya Mandlekar; John M Pezzuto; Ah-Ng Tony Kong
Resveratrol inhibits phorbol ester and UV-induced activator protein 1 activation by interfering with mitogen-activated protein kinase pathways.
Molecular pharmacology 2001;60(1):217-24.
2001: A A Fasanmade; Edward D Owuor; R P Ee; D Qato; M Heller; Ah-Ng Tony Kong
Quinacrine induces cytochrome c-dependent apoptotic signaling in human cervical carcinoma cells.
Archives of pharmacal research 2001;24(2):126-35.
2000: R Yu; Chin Chen; Yin-Yuan Mo; Vidya Hebbar; Edward D Owuor; Tse-Hua Tan; Ah-Ng Tony Kong
Activation of mitogen-activated protein kinase pathways induces antioxidant response element-mediated gene expression via a Nrf2-dependent mechanism.
The Journal of biological chemistry 2000;275(51):39907-13.
2000: Chin Chen; R Yu; Edward D Owuor; Ah-Ng Tony Kong
Activation of antioxidant-response element (ARE), mitogen-activated protein kinases (MAPKs) and caspases by major green tea polyphenol components during cell survival and death.
Archives of pharmacal research 2000;23(6):605-12.
2000: Sandhya Mandlekar; Vidya Hebbar; Konstantin Christov-Tzelkov; Ah-Ng Tony Kong
Pharmacodynamics of tamoxifen and its 4-hydroxy and N-desmethyl metabolites: activation of caspases and induction of apoptosis in rat mammary tumors and in human breast cancer cell lines.
Cancer research 2000;60(23):6601-6.
2000: Sandhya Mandlekar; R Yu; Tse-Hua Tan; Ah-Ng Tony Kong
Activation of caspase-3 and c-Jun NH2-terminal kinase-1 signaling pathways in tamoxifen-induced apoptosis of human breast cancer cells.
Cancer research 2000;60(21):5995-6000.
2000: R Yu; Sandhya Mandlekar; Ah-Ng Tony Kong
Molecular mechanisms of butylated hydroxylanisole-induced toxicity: induction of apoptosis through direct release of cytochrome c.
Molecular pharmacology 2000;58(2):431-7.
2000: R Yu; Sandhya Mandlekar; S Ruben; J Ni; Ah-Ng Tony Kong
Tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in androgen-independent prostate cancer cells.
Cancer research 2000;60(9):2384-9.
2000: R Yu; Sandhya Mandlekar; Tse-Hua Tan; Ah-Ng Tony Kong
Activation of p38 and c-Jun N-terminal kinase pathways and induction of apoptosis by chelerythrine do not require inhibition of protein kinase C.
The Journal of biological chemistry 2000;275(13):9612-9.
2000: Ah-Ng Tony Kong; R Yu; Chin Chen; Sandhya Mandlekar; T Primiano
Signal transduction events elicited by natural products: role of MAPK and caspase pathways in homeostatic response and induction of apoptosis.
Archives of pharmacal research 2000;23(1):1-16.
2000: R Yu; Sandhya Mandlekar; W Lei; W E Fahl; Tse-Hua Tan; Ah-Ng Tony Kong
p38 mitogen-activated protein kinase negatively regulates the induction of phase II drug-metabolizing enzymes that detoxify carcinogens.
The Journal of biological chemistry 2000;275(4):2322-7.
1999: R Yu; W Lei; Sandhya Mandlekar; M J Weber; Channing J Der; J Wu; Ah-Ng Tony Kong
Role of a mitogen-activated protein kinase pathway in the induction of phase II detoxifying enzymes by chemicals.
The Journal of biological chemistry 1999;274(39):27545-52.
1999: Ah-Ng Tony Kong; Sandhya Mandlekar; R Yu; W Lei; A Fasanmande
Pharmacodynamics and toxicodynamics of drug action: signaling in cell survival and cell death.
Pharmaceutical research 1999;16(6):790-8.
1999: Alexander A Shtil; Sandhya Mandlekar; R Yu; robert walter; K Hagen; Tse-Hua Tan; Igor B Roninson; Ah-Ng Tony Kong
Differential regulation of mitogen-activated protein kinases by microtubule-binding agents in human breast cancer cells.
Oncogene 1999;18(2):377-84.
1998: Ah-Ng Tony Kong; R Yu; W Lei; Sandhya Mandlekar; Tse-Hua Tan; David S Ucker
Differential activation of MAPK and ICE/Ced-3 protease in chemical-induced apoptosis. The role of oxidative stress in the regulation of mitogen-activated protein kinases (MAPKs) leading to gene expression and survival or activation of caspases leading to apoptosis.
Restorative neurology and neuroscience 1998;12(2-3):63-70.
1998: W Lei; R Yu; Sandhya Mandlekar; Ah-Ng Tony Kong
Induction of apoptosis and activation of interleukin 1beta-converting enzyme/Ced-3 protease (caspase-3) and c-Jun NH2-terminal kinase 1 by benzo(a)pyrene.
Cancer research 1998;58(10):2102-6.
1998: R Yu; Sandhya Mandlekar; Kevin Harvey; David S Ucker; Ah-Ng Tony Kong
Chemopreventive isothiocyanates induce apoptosis and caspase-3-like protease activity.
Cancer research 1998;58(3):402-8.
1998: Yi-Rong Chen; Wei Wang; Ah-Ng Tony Kong; Tse-Hua Tan
Molecular mechanisms of c-Jun N-terminal kinase-mediated apoptosis induced by anticarcinogenic isothiocyanates.
The Journal of biological chemistry 1998;273(3):1769-75.
1997: R Yu; Tse-Hua Tan; Ah-Ng Tony Kong
Butylated hydroxyanisole and its metabolite tert-butylhydroquinone differentially regulate mitogen-activated protein kinases. The role of oxidative stress in the activation of mitogen-activated protein kinases by phenolic antioxidants.
The Journal of biological chemistry 1997;272(46):28962-70.
1997: Q Chu; W Lei; Krishnamurthy P Gudehithlu; George Matwyshyn; Maurizio Bocchetta; Ah-Ng Tony Kong
cDNA cloning of the mouse bilirubin/phenol family of UDP-glucuronosyltransferase (mUGTbr2-like).
Pharmaceutical research 1997;14(5):662-6.
1997: J L Duh; R Yu; J J Jiao; George Matwyshyn; W Li; T H Tan; Ah-Ng Tony Kong
Activation of signal transduction kinases by tamoxifen.
Pharmaceutical research 1997;14(2):186-9.
1997: R Yu; J J Jiao; J L Duh; Krishnamurthy P Gudehithlu; T H Tan; Ah-Ng Tony Kong
Activation of mitogen-activated protein kinases by green tea polyphenols: potential signaling pathways in the regulation of antioxidant-responsive element-mediated phase II enzyme gene expression.
Carcinogenesis 1997;18(2):451-6.
1996: E T Hellriegel; George Matwyshyn; P Fei; K H Dragnev; Raymond W Nims; Ronald A Lubet; Ah-Ng Tony Kong
Regulation of gene expression of various phase I and phase II drug-metabolizing enzymes by tamoxifen in rat liver.
Biochemical pharmacology 1996;52(10):1561-8.
1996: R Yu; Alexander A Shtil; Tse-Hua Tan; Igor B Roninson; Ah-Ng Tony Kong
Adriamycin activates c-jun N-terminal kinase in human leukemia cells: a relevance to apoptosis.
Cancer letters 1996;107(1):73-81.
1996: P Fei; George Matwyshyn; T H Rushmore; Ah-Ng Tony Kong
Transcription regulation of rat glutathione S-transferase Ya subunit gene expression by chemopreventive agents.
Pharmaceutical research 1996;13(7):1043-8.
1996: R Yu; J J Jiao; J L Duh; Tse-Hua Tan; Ah-Ng Tony Kong
Phenethyl isothiocyanate, a natural chemopreventive agent, activates c-Jun N-terminal kinase 1.
Cancer research 1996;56(13):2954-9.
1995: B K Wong; P Fei; Ah-Ng Tony Kong
Differential induction of UDP-glucuronosyltransferase activity and gene expression in rat liver.
Pharmaceutical research 1995;12(7):1105-8.
1995: Ah-Ng Tony Kong; P Fei; B K Wong
Differential expression of the phenol family of UDP-glucuronosyltransferases in hepatoma cell lines.
Pharmaceutical research 1995;12(2):309-12.
1994: Ah-Ng Tony Kong; P Fei
Molecular cloning of three sulfotransferase cDNAs from mouse liver.
Chemico-biological interactions 1994;92(1-3):161-8.
1993: Ah-Ng Tony Kong; D Tao; M Ma; L Yang
Molecular cloning of the alcohol/hydroxysteroid form (mSTa1) of sulfotransferase from mouse liver.
Pharmaceutical research 1993;10(4):627-30.
1993: Ah-Ng Tony Kong; M Ma; D Tao; L Yang
Molecular cloning of two cDNAs encoding the mouse bilirubin/phenol family of UDP-glucuronosyltransferases (mUGTBr/p).
Pharmaceutical research 1993;10(3):461-5.
1993: Ah-Ng Tony Kong; M Ma; D Tao; L Yang
Molecular cloning of cDNA encoding the phenol/aryl form of sulfotransferase (mSTp1) from mouse liver.
Biochimica et biophysica acta 1993;1171(3):315-8.
1992: Ah-Ng Tony Kong; L Yang; M Ma; D Tao; T D Bjornsson
Molecular cloning of the alcohol/hydroxysteroid form (hSTa) of sulfotransferase from human liver.
Biochemical and biophysical research communications 1992;187(1):448-54.