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Ah-Ng Tony Kong

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Co-Publications
Name
31
Shen, Guoxiang
25
Khor, Tin Oo
23
Hebbar, Vidya
23
Hu, Rong
23
Xu, Changjiang
21
Yu, R
18
Yu, Siwang
18
Keum, Young-Sam
18
Mandlekar, Sandhya
16
Chen, Chi
14
Li, Wenge
12
Lin, Wen
11
Tan, Tse-Hua
10
Nair, Sujit
10
Kim, Jung-Hwan

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Publications

TOP 3
Shen Guoxiang; Kong Ah-Ng
Nrf2 plays an important role in coordinated regulation of Phase II drug metabolism enzymes and Phase III drug transporters.
Barve Avantika; Chen Chi; Hebbar Vidya; Desiderio Joseph; Saw Constance Lay-Lay; Kong Ah-Ng
Metabolism, oral bioavailability and pharmacokinetics of chemopreventive kaempferol in rats.
Keum Young-Sam; Khor Tin Oo; Lin Wen; Shen Guoxiang; Kwon Ki Han; Barve Avantika; Li Wenge; Kong Ah-Ng
Pharmacokinetics and pharmacodynamics of broccoli sprouts on the suppression of prostate cancer in transgenic adenocarcinoma of mouse prostate (TRAMP) mice: implication of induction of Nrf2, HO-1 and apoptosis and the suppression of Akt-dependent kinase pathway.

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All Publications

2009: Shen Guoxiang; Kong Ah-Ng
Nrf2 plays an important role in coordinated regulation of Phase II drug metabolism enzymes and Phase III drug transporters.
Biopharmaceutics & drug disposition 2009;30(7):345-55.
2009: Barve Avantika; Chen Chi; Hebbar Vidya; Desiderio Joseph; Saw Constance Lay-Lay; Kong Ah-Ng
Metabolism, oral bioavailability and pharmacokinetics of chemopreventive kaempferol in rats.
Biopharmaceutics & drug disposition 2009;30(7):356-65.
2009: Keum Young-Sam; Khor Tin Oo; Lin Wen; Shen Guoxiang; Kwon Ki Han; Barve Avantika; Li Wenge; Kong Ah-Ng
Pharmacokinetics and pharmacodynamics of broccoli sprouts on the suppression of prostate cancer in transgenic adenocarcinoma of mouse prostate (TRAMP) mice: implication of induction of Nrf2, HO-1 and apoptosis and the suppression of Akt-dependent kinase pathway.
Pharmaceutical research 2009;26(10):2324-31.
2009: Khor Tin Oo; Yu Siwang; Barve Avanthika; Hao Xingpei; Hong Jin-Liern; Lin Wen; Foster Barbara; Huang Mou-Tuan; Newmark Harold L; Kong Ah-Ng
Dietary feeding of dibenzoylmethane inhibits prostate cancer in transgenic adenocarcinoma of the mouse prostate model.
Cancer research 2009;69(17):7096-102.
2009: Prawan Auemduan; Saw Constance Lay Lay; Khor Tin Oo; Keum Young-Sam; Yu Siwang; Hu Longqin; Kong Ah-Ng
Anti-NF-kappaB and anti-inflammatory activities of synthetic isothiocyanates: effect of chemical structures and cellular signaling.
Chemico-biological interactions 2009;179(2-3):202-11.
2009: Barve Avantika; Khor Tin Oo; Nair Sujit; Reuhl Kenneth; Suh Nanjoo; Reddy Bandaru; Newmark Harold; Kong Ah-Ng
Gamma-tocopherol-enriched mixed tocopherol diet inhibits prostate carcinogenesis in TRAMP mice.
International journal of cancer. Journal international du cancer 2009;124(7):1693-9.
2009: Li Wenge; Kong Ah-Ng
Molecular mechanisms of Nrf2-mediated antioxidant response.
Molecular carcinogenesis 2009;48(2):91-104.
2008: Li Wenge; Khor Tin Oo; Xu Changjiang; Shen Guoxiang; Jeong Woo-Sik; Yu Siwang; Kong Ah-Ng
Activation of Nrf2-antioxidant signaling attenuates NFkappaB-inflammatory response and elicits apoptosis.
Biochemical pharmacology 2008;76(11):1485-9.
2008: Khor Tin Oo; Yu Siwang; Kong Ah-Ng
Dietary cancer chemopreventive agents - targeting inflammation and Nrf2 signaling pathway.
Planta medica 2008;74(13):1540-7.
2008: Lin Wen; Wu Rachel T; Wu Tienyuan; Khor Tin-Oo; Wang Hu; Kong Ah-Ng
Sulforaphane suppressed LPS-induced inflammation in mouse peritoneal macrophages through Nrf2 dependent pathway.
Biochemical pharmacology 2008;76(8):967-73.
2008: Li Wenge; Yu Siwang; Liu Tong; Kim Jung-Hwan; Blank Volker; Li Hong; Kong A-N Tony
Heterodimerization with small Maf proteins enhances nuclear retention of Nrf2 via masking the NESzip motif.
Biochimica et biophysica acta 2008;1783(10):1847-56.
2008: Barve Avantika; Khor Tin Oo; Nair Sujit; Lin Wen; Yu Siwang; Jain Mohit Raja; Chan Jefferson Y; Kong Ah-Ng
Pharmacogenomic profile of soy isoflavone concentrate in the prostate of Nrf2 deficient and wild-type mice.
Journal of pharmaceutical sciences 2008;97(10):4528-45.
2008: Yu Siwang; Shen Guoxiang; Khor Tin Oo; Kim Jung-Hwan; Kong Ah-Ng Tony
Curcumin inhibits Akt/mammalian target of rapamycin signaling through protein phosphatase-dependent mechanism.
Molecular cancer therapeutics 2008;7(9):2609-20.
2008: Kong Ah-Ng Tony
Theme section on cancer chemoprevention.
Pharmaceutical research 2008;25(9):2094-6.
2008: Barve Avantika; Khor Tin Oo; Hao Xingpei; Keum Young-Sam; Yang Chung S; Reddy Bandaru; Kong Ah-Ng Tony
Murine prostate cancer inhibition by dietary phytochemicals--curcumin and phenyethylisothiocyanate.
Pharmaceutical research 2008;25(9):2181-9.
2008: Khor Tin Oo; Huang Mou-Tuan; Prawan Auemduan; Liu Yue; Hao Xingpei; Yu Siwang; Cheung William Ka Lung; Chan Jefferson Y; Reddy Bandaru S; Yang Chung S; Kong Ah-Ng
Increased susceptibility of Nrf2 knockout mice to colitis-associated colorectal cancer.
Cancer prevention research (Philadelphia, Pa.) 2008;1(3):187-91.
2008: Cheung Ka Lung; Khor Tin Oo; Yu Siwang; Kong Ah-Ng Tony
PEITC induces G1 cell cycle arrest on HT-29 cells through the activation of p38 MAPK signaling pathway.
The AAPS journal 2008;10(2):277-81.
2008: Khor Tin Oo; Cheung William Ka Lung; Prawan Auemduan; Reddy Bandaru S; Kong Ah-Ng Tony
Chemoprevention of familial adenomatous polyposis in Apc(Min/+) mice by phenethyl isothiocyanate (PEITC).
Molecular carcinogenesis 2008;47(5):321-5.
2008: Van Berkel Gary J; Kertesz Vilmos; Koeplinger Kenneth A; Vavrek Marissa; Kong Ah-Ng Tony
Liquid microjunction surface sampling probe electrospray mass spectrometry for detection of drugs and metabolites in thin tissue sections.
Journal of mass spectrometry : JMS 2008;43(4):500-8.
2008: Prawan Auemduan; Keum Young-Sam; Khor Tin Oo; Yu Siwang; Nair Sujit; Li Wenge; Hu Longqin; Kong Ah-Ng Tony
Structural influence of isothiocyanates on the antioxidant response element (ARE)-mediated heme oxygenase-1 (HO-1) expression.
Pharmaceutical research 2008;25(4):836-44.
2008: Keum Young-Sam; Chang Peter Pil-Jae; Kwon Ki Han; Yuan Xiaoling; Li Wenge; Hu Longqin; Kong Ah-Ng Tony
3-Morpholinopropyl isothiocyanate is a novel synthetic isothiocyanate that strongly induces the antioxidant response element-dependent Nrf2-mediated detoxifying/antioxidant enzymes in vitro and in vivo.
Carcinogenesis 2008;29(3):594-9.
2008: Nair Sujit; Hebbar Vidya; Shen Guoxiang; Gopalakrishnan Avantika; Khor Tin Oo; Yu Siwang; Xu Changjiang; Kong Ah-Ng
Synergistic effects of a combination of dietary factors sulforaphane and (-) epigallocatechin-3-gallate in HT-29 AP-1 human colon carcinoma cells.
Pharmaceutical research 2008;25(2):387-99.
2008: Zheng Xi; Chang Richard L; Cui Xiao-Xing; Avila Gina; Huang Mou-Tuan; Liu Yue; Kong Ah Ng Tony; Rabson Arnold B; Conney Allan H
Inhibition of NF-kappaB by (E)3-[(4-methylphenyl)-sulfonyl]-2-propenenitrile (BAY11-7082; BAY) is associated with enhanced 12-O-tetradecanoylphorbol-13-acetate-induced growth suppression and apoptosis in human prostate cancer PC-3 cells.
International journal of oncology 2008;32(1):257-64.
2007: Shen Guoxiang; Khor Tin Oo; Hu Rong; Yu Siwang; Nair Sujit; Ho Chi-Tang; Reddy Bandaru S; Huang Mou-Tuan; Newmark Harold L; Kong Ah-Ng Tony
Chemoprevention of familial adenomatous polyposis by natural dietary compounds sulforaphane and dibenzoylmethane alone and in combination in ApcMin/+ mouse.
Cancer research 2007;67(20):9937-44.
2007: Zheng Xi; Cui Xiao-Xing; Avila Gina E; Huang Mou-Tuan; Liu Yue; Patel Jagruti; Kong Ah Ng Tony; Paulino Raphael; Shih Weichung Joe; Lin Yong; Rabson Arnold B; Reddy Bandaru S; Conney Allan H
Atorvastatin and celecoxib inhibit prostate PC-3 tumors in immunodeficient mice.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(18 Pt 1):5480-7.
2007: Kwon Ki Han; Barve Avantika; Yu Siwang; Huang Mou-Tuan; Kong Ah-Ng Tony
Cancer chemoprevention by phytochemicals: potential molecular targets, biomarkers and animal models.
Acta pharmacologica Sinica 2007;28(9):1409-21.
2007: Kong Ah-Ng Tony
Special issue on "molecular targets, biomarkers and animal models for anti-cancer pharmacological research: potentials and challenges from chemoprevention to chemotherapeutic treatment".
Acta pharmacologica Sinica 2007;28(9):1261.
2007: Yu Siwang; Kong Ah-Ng
Targeting carcinogen metabolism by dietary cancer preventive compounds.
Current cancer drug targets 2007;7(5):416-24.
2007: Shen Guoxiang; Hong Jin-Liern; Kong Ah-Ng Tony
Development and validation of an HPLC method for the determination of dibenzoylmethane in rat plasma and its application to the pharmacokinetic study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2007;852(1-2):56-61.
2007: Nair Sujit; Li Wenge; Kong Ah-Ng Tony
Natural dietary anti-cancer chemopreventive compounds: redox-mediated differential signaling mechanisms in cytoprotection of normal cells versus cytotoxicity in tumor cells.
Acta pharmacologica Sinica 2007;28(4):459-72.
2007: Nair Sujit; Xu Changjiang; Shen Guoxiang; Hebbar Vidya; Gopalakrishnan Avantika; Hu Rong; Jain Mohit Raja; Liew Celine; Chan Jefferson Y; Kong Ah-Ng Tony
Toxicogenomics of endoplasmic reticulum stress inducer tunicamycin in the small intestine and liver of Nrf2 knockout and C57BL/6J mice.
Toxicology letters 2007;168(1):21-39.
2006: Khor Tin Oo; Huang Mou-Tuan; Kwon Ki Han; Chan Jefferson Y; Reddy Bandaru S; Kong Ah-Ng
Nrf2-deficient mice have an increased susceptibility to dextran sulfate sodium-induced colitis.
Cancer research 2006;66(24):11580-4.
2006: Khor Tin Oo; Hu Rong; Shen Guoxiang; Jeong Woo-Sik; Hebbar Vidya; Chen Chi; Xu Changjiang; Nair Sujit; Reddy Bandaru; Chada Kiran; Kong Ah-Ng Tony
Pharmacogenomics of cancer chemopreventive isothiocyanate compound sulforaphane in the intestinal polyps of ApcMin/+ mice.
Biopharmaceutics & drug disposition 2006;27(9):407-20.
2006: Keum Young-Sam; Han Yong-Hae; Liew Celine; Kim Jung-Hwan; Xu Changjiang; Yuan Xiaoling; Shakarjian Michael P; Chong Saeho; Kong Ah-Ng
Induction of heme oxygenase-1 (HO-1) and NAD[P]H: quinone oxidoreductase 1 (NQO1) by a phenolic antioxidant, butylated hydroxyanisole (BHA) and its metabolite, tert-butylhydroquinone (tBHQ) in primary-cultured human and rat hepatocytes.
Pharmaceutical research 2006;23(11):2586-94.
2006: Nair Sujit; Xu Changjiang; Shen Guoxiang; Hebbar Vidya; Gopalakrishnan Avantika; Hu Rong; Jain Mohit Raja; Lin Wen; Keum Young-Sam; Liew Celine; Chan Jefferson Y; Kong Ah-Ng Tony
Pharmacogenomics of phenolic antioxidant butylated hydroxyanisole (BHA) in the small intestine and liver of Nrf2 knockout and C57BL/6J mice.
Pharmaceutical research 2006;23(11):2621-37.
2006: Yuan Xiaoling; Xu Changjiang; Pan Zui; Keum Young-Sam; Kim Jung-Hwan; Shen Guoxiang; Yu Siwang; Oo Khor Tin; Ma Jianjie; Kong Ah-Ng Tony
Butylated hydroxyanisole regulates ARE-mediated gene expression via Nrf2 coupled with ERK and JNK signaling pathway in HepG2 cells.
Molecular carcinogenesis 2006;45(11):841-50.
2006: Hu Rong; Xu Changjiang; Shen Guoxiang; Jain Mohit R; Khor Tin Oo; Gopalkrishnan Avantika; Lin Wen; Reddy Bandaru; Chan Jefferson Y; Kong Ah-Ng Tony
Gene expression profiles induced by cancer chemopreventive isothiocyanate sulforaphane in the liver of C57BL/6J mice and C57BL/6J/Nrf2 (-/-) mice.
Cancer letters 2006;243(2):170-92.
2006: Hu Rong; Shen Guoxiang; Yerramilli Usha Rao; Lin Wen; Xu Changjiang; Nair Sujit; Kong Ah-Ng Tony
In vivo pharmacokinetics, activation of MAPK signaling and induction of phase II/III drug metabolizing enzymes/transporters by cancer chemopreventive compound BHA in the mice.
Archives of pharmacal research 2006;29(10):911-20.
2006: Hu Rong; Xu Changjiang; Shen Guoxiang; Jain Mohit R; Khor Tin Oo; Gopalkrishnan Avantika; Lin Wen; Reddy Bandaru; Chan Jefferson Y; Kong Ah-Ng Tony
Identification of Nrf2-regulated genes induced by chemopreventive isothiocyanate PEITC by oligonucleotide microarray.
Life sciences 2006;79(20):1944-55.
2006: Hu Rong; Khor Tin Oo; Shen Guoxiang; Jeong Woo-Sik; Hebbar Vidya; Chen Chi; Xu Changjiang; Reddy Bandaru; Chada Kiran; Kong Ah-Ng Tony
Cancer chemoprevention of intestinal polyposis in ApcMin/+ mice by sulforaphane, a natural product derived from cruciferous vegetable.
Carcinogenesis 2006;27(10):2038-46.
2006: Keum Young-Sam; Yu Siwang; Chang Peter Pil-Jae; Yuan Xiaoling; Kim Jung-Hwan; Xu Changjiang; Han Jiahuai; Agarwal Anupam; Kong Ah-Ng Tony
Mechanism of action of sulforaphane: inhibition of p38 mitogen-activated protein kinase isoforms contributing to the induction of antioxidant response element-mediated heme oxygenase-1 in human hepatoma HepG2 cells.
Cancer research 2006;66(17):8804-13.
2006: Li Wenge; Yu Si-Wang; Kong A-N Tony
Nrf2 possesses a redox-sensitive nuclear exporting signal in the Neh5 transactivation domain.
The Journal of biological chemistry 2006;281(37):27251-63.
2006: Gopalakrishnan Avanthika; Xu Chang-Jiang; Nair Sujit S; Chen Chi; Hebbar Vidya; Kong Ah-Ng Tony
Modulation of activator protein-1 (AP-1) and MAPK pathway by flavonoids in human prostate cancer PC3 cells.
Archives of pharmacal research 2006;29(8):633-44.
2006: Xu Changjiang; Yuan Xiaoling; Pan Zui; Shen Guoxiang; Kim Jung-Hwan; Yu Siwang; Khor Tin Oo; Li Wenge; Ma Jianjie; Kong Ah-Ng Tony
Mechanism of action of isothiocyanates: the induction of ARE-regulated genes is associated with activation of ERK and JNK and the phosphorylation and nuclear translocation of Nrf2.
Molecular cancer therapeutics 2006;5(8):1918-26.
2006: Mandlekar Sandhya; Hong Jin-Liern; Kong Ah-Ng Tony
Modulation of metabolic enzymes by dietary phytochemicals: a review of mechanisms underlying beneficial versus unfavorable effects.
Current drug metabolism 2006;7(6):661-75.
2006: Xu Changjiang; Huang Mou-Tuan; Shen Guoxiang; Yuan Xiaoling; Lin Wen; Khor Tin Oo; Conney Allan H; Kong Ah-Ng Tony
Inhibition of 7,12-dimethylbenz(a)anthracene-induced skin tumorigenesis in C57BL/6 mice by sulforaphane is mediated by nuclear factor E2-related factor 2.
Cancer research 2006;66(16):8293-6.
2006: Khor Tin Oo; Ibrahim Sherif; Kong Ah-Ng Tony
Toxicogenomics in drug discovery and drug development: potential applications and future challenges.
Pharmaceutical research 2006;23(8):1659-64.
2006: Zheng Xi; Chang Richard L; Cui Xiao-Xing; Avila Gina E; Hebbar Vidya; Garzotto Mark; Shih Weichung Joe; Lin Yong; Lu Shou-En; Rabson Arnold B; Kong Ah Ng Tony; Conney Allan H
Effects of 12-O-tetradecanoylphorbol-13-acetate (TPA) in combination with paclitaxel (Taxol) on prostate Cancer LNCaP cells cultured in vitro or grown as xenograft tumors in immunodeficient mice.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(11 Pt 1):3444-51.
2006: Lin Wen; Shen Guoxiang; Yuan Xiaoling; Jain Mohit R; Yu Siwang; Zhang Aihua; Chen J Don; Kong Ah-Ng Tony
Regulation of Nrf2 transactivation domain activity by p160 RAC3/SRC3 and other nuclear co-regulators.
Journal of biochemistry and molecular biology 2006;39(3):304-10.
2006: Reddy Bandaru S; Wang Chung Xiou; Kong Ah-Ng; Khor Tin Oo; Zheng Xi; Steele Vernon E; Kopelovich Levy; Rao Chinthalapally V
Prevention of azoxymethane-induced colon cancer by combination of low doses of atorvastatin, aspirin, and celecoxib in F 344 rats.
Cancer research 2006;66(8):4542-6.
2006: Kim Jung-Hwan; Xu Changjiang; Keum Young-Sam; Reddy Bandaru; Conney Allan; Kong Ah-Ng Tony
Inhibition of EGFR signaling in human prostate cancer PC-3 cells by combination treatment with beta-phenylethyl isothiocyanate and curcumin.
Carcinogenesis 2006;27(3):475-82.
2006: Xu Changjiang; Shen Guoxiang; Yuan Xiaoling; Kim Jung-Hwan; Gopalkrishnan Avantika; Keum Young-Sam; Nair Sujit; Kong Ah-Ng Tony
ERK and JNK signaling pathways are involved in the regulation of activator protein 1 and cell death elicited by three isothiocyanates in human prostate cancer PC-3 cells.
Carcinogenesis 2006;27(3):437-45.
2006: Shen Guoxiang; Xu Changjiang; Chen Chi; Hebbar Vidya; Kong Ah-Ng Tony
p53-independent G1 cell cycle arrest of human colon carcinoma cells HT-29 by sulforaphane is associated with induction of p21CIP1 and inhibition of expression of cyclin D1.
Cancer chemotherapy and pharmacology 2006;57(3):317-27.
2006: Jeong Woo-Sik; Jun Mira; Kong Ah-Ng Tony
Nrf2: a potential molecular target for cancer chemoprevention by natural compounds.
Antioxidants & redox signaling 2006;8(1-2):99-106.
2006: Shen Guoxiang; Xu Changjiang; Hu Rong; Jain Mohit R; Gopalkrishnan Avantika; Nair Sujit; Huang Mou-Tuan; Chan Jefferson Y; Kong Ah-Ng Tony
Modulation of nuclear factor E2-related factor 2-mediated gene expression in mice liver and small intestine by cancer chemopreventive agent curcumin.
Molecular cancer therapeutics 2006;5(1):39-51.
2006: Khor Tin Oo; Keum Young-Sam; Lin Wen; Kim Jung-Hwan; Hu Rong; Shen Guoxiang; Xu Changjiang; Gopalakrishnan Avanthika; Reddy Bandaru; Zheng Xi; Conney Allan H; Kong Ah-Ng Tony
Combined inhibitory effects of curcumin and phenethyl isothiocyanate on the growth of human PC-3 prostate xenografts in immunodeficient mice.
Cancer research 2006;66(2):613-21.
2005: Shen Guoxiang; Jeong Woo-Sik; Hu Rong; Kong Ah-Ng Tony
Regulation of Nrf2, NF-kappaB, and AP-1 signaling pathways by chemopreventive agents.
Antioxidants & redox signaling 2005;7(11-12):1648-63.
2005: Shen Guoxiang; Xu Changjiang; Hu Rong; Jain Mohit R; Nair Sujit; Lin Wen; Yang Chung S; Chan Jefferson Y; Kong A-N Tony
Comparison of (-)-epigallocatechin-3-gallate elicited liver and small intestine gene expression profiles between C57BL/6J mice and C57BL/6J/Nrf2 (-/-) mice.
Pharmaceutical research 2005;22(11):1805-20.
2005: Keum Young-Sam; Jeong Woo-Sik; Kong Ah-Ng Tony
Chemopreventive functions of isothiocyanates.
Drug news & perspectives 2005;18(7):445-51.
2005: Li Wenge; Jain Mohit R; Chen Chi; Yue Xin; Hebbar Vidya; Zhou Renping; Kong A-N Tony
Nrf2 Possesses a redox-insensitive nuclear export signal overlapping with the leucine zipper motif.
The Journal of biological chemistry 2005;280(31):28430-8.
2005: Chen Chi; Kong Ah-Ng Tony
Dietary cancer-chemopreventive compounds: from signaling and gene expression to pharmacological effects.
Trends in pharmacological sciences 2005;26(6):318-26.
2005: Xu Changjiang; Shen Guoxiang; Chen Chi; Gélinas Céline; Kong Ah-Ng Tony
Suppression of NF-kappaB and NF-kappaB-regulated gene expression by sulforaphane and PEITC through IkappaBalpha, IKK pathway in human prostate cancer PC-3 cells.
Oncogene 2005;24(28):4486-95.
2005: Hebbar Vidya; Shen Guoxiang; Hu Rong; Kim Bok-Ryang; Chen Chi; Korytko Peter J; Crowell James A; Levine Barry S; Kong A-N Tony
Toxicogenomics of resveratrol in rat liver.
Life sciences 2005;76(20):2299-314.
2005: Xu Changjiang; Li Christina Yong-Tao; Kong Ah-Ng Tony
Induction of phase I, II and III drug metabolism/transport by xenobiotics.
Archives of pharmacal research 2005;28(3):249-68.
2005: Jeong Woo-Sik; Keum Young-Sam; Chen Chi; Jain Mohit R; Shen Guoxiang; Kim Jung-Hwan; Li Wenge; Kong Ah-Ng Tony
Differential expression and stability of endogenous nuclear factor E2-related factor 2 (Nrf2) by natural chemopreventive compounds in HepG2 human hepatoma cells.
Journal of biochemistry and molecular biology 2005;38(2):167-76.
2004: Chen Chi; Pung Daniel; Leong Vasco; Hebbar Vidya; Shen Guoxiang; Nair Sujit; Li Wenge; Kong A-N Tony
Induction of detoxifying enzymes by garlic organosulfur compounds through transcription factor Nrf2: effect of chemical structure and stress signals.
Free radical biology & medicine 2004;37(10):1578-90.
2004: Keum Young-Sam; Jeong Woo-Sik; Kong A N Tony
Chemoprevention by isothiocyanates and their underlying molecular signaling mechanisms.
Mutation research 2004;555(1-2):191-202.
2004: Kong A-N Tony
Signal transduction in cancer chemoprevention.
Mutation research 2004;555(1-2):1-2.
2004: Hu Rong; Hebbar Vidya; Kim Bok-Ryang; Chen Chi; Winnik Bozena; Buckley Brian; Soteropoulos Patricia; Tolias Peter; Hart Ronald P; Kong A-N Tony
In vivo pharmacokinetics and regulation of gene expression profiles by isothiocyanate sulforaphane in the rat.
The Journal of pharmacology and experimental therapeutics 2004;310(1):263-71.
2004: Chen Chi; Kong A-N Tony
Dietary chemopreventive compounds and ARE/EpRE signaling.
Free radical biology & medicine 2004;36(12):1505-16.
2004: Shen Guoxiang; Hebbar Vidya; Nair Sujit; Xu Changjiang; Li Wenge; Lin Wen; Keum Young-Sam; Han Jiahuai; Gallo Michael A; Kong A-N Tony
Regulation of Nrf2 transactivation domain activity. The differential effects of mitogen-activated protein kinase cascades and synergistic stimulatory effect of Raf and CREB-binding protein.
The Journal of biological chemistry 2004;279(22):23052-60.
2004: Jeong Woo-Sik; Kim In-Wha; Hu Rong; Kong Ah-Ng Tony
Modulatory properties of various natural chemopreventive agents on the activation of NF-kappaB signaling pathway.
Pharmaceutical research 2004;21(4):661-70.
2004: Jeong Woo-Sik; Kim In-Wha; Hu Rong; Kong Ah-Ng Tony
Modulation of AP-1 by natural chemopreventive compounds in human colon HT-29 cancer cell line.
Pharmaceutical research 2004;21(4):649-60.
2004: Hu Rong; Kong Ah-Ng Tony
Activation of MAP kinases, apoptosis and nutrigenomics of gene expression elicited by dietary cancer-prevention compounds.
Nutrition (Burbank, Los Angeles County, Calif.) 2004;20(1):83-8.
2003: Kim Bok-Ryang; Hu Rong; Keum Young-Sam; Hebbar Vidya; Shen Guoxiang; Nair Sujit S; Kong A-N Tony
Effects of glutathione on antioxidant response element-mediated gene expression and apoptosis elicited by sulforaphane.
Cancer research 2003;63(21):7520-5.
2003: Keum Young-Sam; Owuor Edward D; Kim Bok-Ryang; Hu Rong; Kong A N Tony
Involvement of Nrf2 and JNK1 in the activation of antioxidant responsive element (ARE) by chemopreventive agent phenethyl isothiocyanate (PEITC).
Pharmaceutical research 2003;20(9):1351-6.
2003: Hu Rong; Kim Bok Ryang; Chen Chi; Hebbar Vidya; Kong A-N Tony
The roles of JNK and apoptotic signaling pathways in PEITC-mediated responses in human HT-29 colon adenocarcinoma cells.
Carcinogenesis 2003;24(8):1361-7.
2003: Chen Chi; Shen Guoxiang; Hebbar Vidya; Hu Rong; Owuor Edward D; Kong A-N Tony
Epigallocatechin-3-gallate-induced stress signals in HT-29 human colon adenocarcinoma cells.
Carcinogenesis 2003;24(8):1369-78.
2003: Jiang Zhi-Qiang; Chen Chi; Yang Bo; Hebbar Vidya; Kong A-N Tony
Differential responses from seven mammalian cell lines to the treatments of detoxifying enzyme inducers.
Life sciences 2003;72(20):2243-53.
2002: Chin Khew-Voon; Kong A N Tony
Application of DNA microarrays in pharmacogenomics and toxicogenomics.
Pharmaceutical research 2002;19(12):1773-8.
2002: Misra Parimal; Owuor Edward D; Li Wenge; Yu Songtao; Qi Chao; Meyer Kirstin; Zhu Yi-Jun; Rao M Sambasiva; Kong A-N Tony; Reddy Janardan K
Phosphorylation of transcriptional coactivator peroxisome proliferator-activated receptor (PPAR)-binding protein (PBP). Stimulation of transcriptional regulation by mitogen-activated protein kinase.
The Journal of biological chemistry 2002;277(50):48745-54.
2002: Rushmore Thomas H; Kong A-N Tony
Pharmacogenomics, regulation and signaling pathways of phase I and II drug metabolizing enzymes.
Current drug metabolism 2002;3(5):481-90.
2002: Chen Yi-Rong; Han Jin; Kori Rajashree; Kong A-N Tony; Tan Tse-Hua
Phenylethyl isothiocyanate induces apoptotic signaling via suppressing phosphatase activity against c-Jun N-terminal kinase.
The Journal of biological chemistry 2002;277(42):39334-42.
2002: Owuor Edward D; Kong Ah-Ng Tony
Antioxidants and oxidants regulated signal transduction pathways.
Biochemical pharmacology 2002;64(5-6):765-70.
2001: Mandlekar S; Kong A N
Mechanisms of tamoxifen-induced apoptosis.
Apoptosis : an international journal on programmed cell death 2001;6(6):469-77.
2001: Kong A N; Yu R; Hebbar V; Chen C; Owuor E; Hu R; Ee R; Mandlekar S
Signal transduction events elicited by cancer prevention compounds.
Mutation research 2001;480-481():231-41.
2001: Kong A N; Owuor E; Yu R; Hebbar V; Chen C; Hu R; Mandlekar S
Induction of xenobiotic enzymes by the MAP kinase pathway and the antioxidant or electrophile response element (ARE/EpRE).
Drug metabolism reviews 2001;33(3-4):255-71.
2001: Yu R; Hebbar V; Kim D W; Mandlekar S; Pezzuto J M; Kong A N
Resveratrol inhibits phorbol ester and UV-induced activator protein 1 activation by interfering with mitogen-activated protein kinase pathways.
Molecular pharmacology 2001;60(1):217-24.
2001: Fasanmade A A; Owuor E D; Ee R P; Qato D; Heller M; Kong A N
Quinacrine induces cytochrome c-dependent apoptotic signaling in human cervical carcinoma cells.
Archives of pharmacal research 2001;24(2):126-35.
2000: Chen C; Yu R; Owuor E D; Kong A N
Activation of antioxidant-response element (ARE), mitogen-activated protein kinases (MAPKs) and caspases by major green tea polyphenol components during cell survival and death.
Archives of pharmacal research 2000;23(6):605-12.
2000: Mandlekar S; Hebbar V; Christov K; Kong A N
Pharmacodynamics of tamoxifen and its 4-hydroxy and N-desmethyl metabolites: activation of caspases and induction of apoptosis in rat mammary tumors and in human breast cancer cell lines.
Cancer research 2000;60(23):6601-6.
2000: Yu R; Chen C; Mo Y Y; Hebbar V; Owuor E D; Tan T H; Kong A N
Activation of mitogen-activated protein kinase pathways induces antioxidant response element-mediated gene expression via a Nrf2-dependent mechanism.
The Journal of biological chemistry 2000;275(51):39907-13.
2000: Mandlekar S; Yu R; Tan T H; Kong A N
Activation of caspase-3 and c-Jun NH2-terminal kinase-1 signaling pathways in tamoxifen-induced apoptosis of human breast cancer cells.
Cancer research 2000;60(21):5995-6000.
2000: Yu R; Mandlekar S; Kong A N
Molecular mechanisms of butylated hydroxylanisole-induced toxicity: induction of apoptosis through direct release of cytochrome c.
Molecular pharmacology 2000;58(2):431-7.
2000: Yu R; Mandlekar S; Ruben S; Ni J; Kong A N
Tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in androgen-independent prostate cancer cells.
Cancer research 2000;60(9):2384-9.
2000: Yu R; Mandlekar S; Tan T H; Kong A N
Activation of p38 and c-Jun N-terminal kinase pathways and induction of apoptosis by chelerythrine do not require inhibition of protein kinase C.
The Journal of biological chemistry 2000;275(13):9612-9.
2000: Kong A N; Yu R; Chen C; Mandlekar S; Primiano T
Signal transduction events elicited by natural products: role of MAPK and caspase pathways in homeostatic response and induction of apoptosis.
Archives of pharmacal research 2000;23(1):1-16.
2000: Yu R; Mandlekar S; Lei W; Fahl W E; Tan T H; Kong A N
p38 mitogen-activated protein kinase negatively regulates the induction of phase II drug-metabolizing enzymes that detoxify carcinogens.
The Journal of biological chemistry 2000;275(4):2322-7.
1999: Yu R; Lei W; Mandlekar S; Weber M J; Der C J; Wu J; Kong A N
Role of a mitogen-activated protein kinase pathway in the induction of phase II detoxifying enzymes by chemicals.
The Journal of biological chemistry 1999;274(39):27545-52.
1999: Kong A N; Mandlekar S; Yu R; Lei W; Fasanmande A
Pharmacodynamics and toxicodynamics of drug action: signaling in cell survival and cell death.
Pharmaceutical research 1999;16(6):790-8.
1999: Shtil A A; Mandlekar S; Yu R; Walter R J; Hagen K; Tan T H; Roninson I B; Kong A N
Differential regulation of mitogen-activated protein kinases by microtubule-binding agents in human breast cancer cells.
Oncogene 1999;18(2):377-84.
1998: Kong A N; Yu R; Lei W; Mandlekar S; Tan T H; Ucker D S
Differential activation of MAPK and ICE/Ced-3 protease in chemical-induced apoptosis. The role of oxidative stress in the regulation of mitogen-activated protein kinases (MAPKs) leading to gene expression and survival or activation of caspases leading to apoptosis.
Restorative neurology and neuroscience 1998;12(2-3):63-70.
1998: Lei W; Yu R; Mandlekar S; Kong A N
Induction of apoptosis and activation of interleukin 1beta-converting enzyme/Ced-3 protease (caspase-3) and c-Jun NH2-terminal kinase 1 by benzo(a)pyrene.
Cancer research 1998;58(10):2102-6.
1998: Yu R; Mandlekar S; Harvey K J; Ucker D S; Kong A N
Chemopreventive isothiocyanates induce apoptosis and caspase-3-like protease activity.
Cancer research 1998;58(3):402-8.
1998: Chen Y R; Wang W; Kong A N; Tan T H
Molecular mechanisms of c-Jun N-terminal kinase-mediated apoptosis induced by anticarcinogenic isothiocyanates.
The Journal of biological chemistry 1998;273(3):1769-75.
1997: Yu R; Tan T H; Kong A N
Butylated hydroxyanisole and its metabolite tert-butylhydroquinone differentially regulate mitogen-activated protein kinases. The role of oxidative stress in the activation of mitogen-activated protein kinases by phenolic antioxidants.
The Journal of biological chemistry 1997;272(46):28962-70.
1997: Chu Q; Lei W; Gudehithlu K; Matwyshyn G A; Bocchetta M; Kong A N
cDNA cloning of the mouse bilirubin/phenol family of UDP-glucuronosyltransferase (mUGTbr2-like).
Pharmaceutical research 1997;14(5):662-6.
1997: Duh J L; Yu R; Jiao J J; Matwyshyn G A; Li W; Tan T H; Kong A N
Activation of signal transduction kinases by tamoxifen.
Pharmaceutical research 1997;14(2):186-9.
1997: Yu R; Jiao J J; Duh J L; Gudehithlu K; Tan T H; Kong A N
Activation of mitogen-activated protein kinases by green tea polyphenols: potential signaling pathways in the regulation of antioxidant-responsive element-mediated phase II enzyme gene expression.
Carcinogenesis 1997;18(2):451-6.
1996: Hellriegel E T; Matwyshyn G A; Fei P; Dragnev K H; Nims R W; Lubet R A; Kong A N
Regulation of gene expression of various phase I and phase II drug-metabolizing enzymes by tamoxifen in rat liver.
Biochemical pharmacology 1996;52(10):1561-8.
1996: Yu R; Shtil A A; Tan T H; Roninson I B; Kong A N
Adriamycin activates c-jun N-terminal kinase in human leukemia cells: a relevance to apoptosis.
Cancer letters 1996;107(1):73-81.
1996: Fei P; Matwyshyn G A; Rushmore T H; Kong A N
Transcription regulation of rat glutathione S-transferase Ya subunit gene expression by chemopreventive agents.
Pharmaceutical research 1996;13(7):1043-8.
1996: Yu R; Jiao J J; Duh J L; Tan T H; Kong A N
Phenethyl isothiocyanate, a natural chemopreventive agent, activates c-Jun N-terminal kinase 1.
Cancer research 1996;56(13):2954-9.
1995: Wong B K; Fei P; Kong A N
Differential induction of UDP-glucuronosyltransferase activity and gene expression in rat liver.
Pharmaceutical research 1995;12(7):1105-8.
1995: Kong A N; Fei P; Wong B K
Differential expression of the phenol family of UDP-glucuronosyltransferases in hepatoma cell lines.
Pharmaceutical research 1995;12(2):309-12.
1994: Kong A N; Fei P
Molecular cloning of three sulfotransferase cDNAs from mouse liver.
Chemico-biological interactions 1994;92(1-3):161-8.
1993: Kong A N; Tao D; Ma M; Yang L
Molecular cloning of the alcohol/hydroxysteroid form (mSTa1) of sulfotransferase from mouse liver.
Pharmaceutical research 1993;10(4):627-30.
1993: Kong A N; Ma M; Tao D; Yang L
Molecular cloning of two cDNAs encoding the mouse bilirubin/phenol family of UDP-glucuronosyltransferases (mUGTBr/p).
Pharmaceutical research 1993;10(3):461-5.
1993: Kong A N; Ma M; Tao D; Yang L
Molecular cloning of cDNA encoding the phenol/aryl form of sulfotransferase (mSTp1) from mouse liver.
Biochimica et biophysica acta 1993;1171(3):315-8.
1992: Kong A N; Yang L; Ma M; Tao D; Bjornsson T D
Molecular cloning of the alcohol/hydroxysteroid form (hSTa) of sulfotransferase from human liver.
Biochemical and biophysical research communications 1992;187(1):448-54.

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