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Jörg König

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Chemicals & Drugs

Physiology

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TOP 3
C Fahrmayr; Daniel Auge; Jörg König; M Mieth; K Münch; T Pfeifer; J Segrestaa; A Treiber; Mf Fromm
Phase I and II metabolism and MRP2-mediated export of bosentan in a MDCKII-OATP1B1-CYP3A4-UGT1A1-MRP2 quadruple-transfected cell line.
Sabine Klatt; Martin F Fromm; Jörg König
The influence of oral antidiabetic drugs on cellular drug uptake mediated by hepatic OATP family members.
Anja Kittel; Jörg König; Renke Maas; Jens Martens-Lobenhoffer; Maren Mieth; Stefanie M Bode-Böger; Bernd Hohenstein; Natalia Jarzebska; Norbert Weiss; Roman N Rodionov
In vivo evidence that Agxt2 can regulate plasma levels of dimethylarginines in mice.

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All Publications

2013: C Fahrmayr; Daniel Auge; Jörg König; M Mieth; K Münch; T Pfeifer; J Segrestaa; A Treiber; Mf Fromm
Phase I and II metabolism and MRP2-mediated export of bosentan in a MDCKII-OATP1B1-CYP3A4-UGT1A1-MRP2 quadruple-transfected cell line.
British journal of pharmacology 2013;169(1):21-33.
2013: Sabine Klatt; Martin F Fromm; Jörg König
The influence of oral antidiabetic drugs on cellular drug uptake mediated by hepatic OATP family members.
Basic & clinical pharmacology & toxicology 2013;112(4):244-50.
2013: Anja Kittel; Jörg König; Renke Maas; Jens Martens-Lobenhoffer; Maren Mieth; Stefanie M Bode-Böger; Bernd Hohenstein; Natalia Jarzebska; Norbert Weiss; Roman N Rodionov
In vivo evidence that Agxt2 can regulate plasma levels of dimethylarginines in mice.
Biochemical and biophysical research communications 2013;430(1):84-9.
2012: Joachim Strobel; Maren Mieth; Daniel Auge; Beate Endress; Martin F Fromm; Jörg König; Renke Maas
Interaction of the cardiovascular risk marker asymmetric dimethylarginine (ADMA) with the human cationic amino acid transporter 1 (CAT1).
Journal of molecular and cellular cardiology 2012;53(3):392-400.
2012: Jörg König; Sabine Klatt; Karin Dilger; Martin F Fromm
Characterization of ursodeoxycholic and norursodeoxycholic acid as substrates of the hepatic uptake transporters OATP1B1, OATP1B3, OATP2B1 and NTCP.
Basic & clinical pharmacology & toxicology 2012;111(2):81-6.
2012: C Fahrmayr; Jörg König; M Mieth; Daniel Auge; M F Fromm
Identification of drugs and drug metabolites as substrates of multidrug resistance protein 2 (MRP2) using triple-transfected MDCK-OATP1B1-UGT1A1-MRP2 cells.
British journal of pharmacology 2012;165(6):1836-47.
2011: Fabian Müller; Ingrid Schmidt; Oliver Zolk; Martin F Fromm; Hartmut Glaeser; Jörg König; Renke Maas
Molecular mechanism of renal tubular secretion of the antimalarial drug chloroquine.
Antimicrobial agents and chemotherapy 2011;55(7):3091-8.
2011: Jörg König; Hartmut Glaeser; Markus Keiser; Kathrin Mandery; Ulrich Klotz; Martin F Fromm
Role of organic anion-transporting polypeptides for cellular mesalazine (5-aminosalicylic acid) uptake.
Drug metabolism and disposition: the biological fate of chemicals 2011;39(6):1097-102.
2011: Juergen Kindla; Fabian Müller; Maren Mieth; Martin F Fromm; Jörg König
Influence of non-steroidal anti-inflammatory drugs on organic anion transporting polypeptide (OATP) 1B1- and OATP1B3-mediated drug transport.
Drug metabolism and disposition: the biological fate of chemicals 2011;39(6):1047-53.
2011: Jörg König; Oliver Zolk; K Singer; C Hoffmann; M F Fromm
Double-transfected MDCK cells expressing human OCT1/MATE1 or OCT2/MATE1: determinants of uptake and transcellular translocation of organic cations.
British journal of pharmacology 2011;163(3):546-55.
2011: Juergen Kindla; Tilman T Rau; Rudolf Jung; Peter A Fasching; Reiner Strick; Robert Stoehr; Arndt Hartmann; Martin F Fromm; Jörg König
Expression and localization of the uptake transporters OATP2B1, OATP3A1 and OATP5A1 in non-malignant and malignant breast tissue.
Cancer biology & therapy 2011;11(6):584-91.
2011: Jörg König
Uptake transporters of the human OATP family: molecular characteristics, substrates, their role in drug-drug interactions, and functional consequences of polymorphisms.
Handbook of experimental pharmacology 2011;(201):1-28.
2010: Kathrin Mandery; Krystyna Bujok; Ingrid Schmidt; Markus Keiser; Werner Siegmund; Bettina Balk; Jörg König; Martin F Fromm; Hartmut Glaeser
Influence of the flavonoids apigenin, kaempferol, and quercetin on the function of organic anion transporting polypeptides 1A2 and 2B1.
Biochemical pharmacology 2010;80(11):1746-53.
2010: Christina Fahrmayr; Martin F Fromm; Jörg König
Hepatic OATP and OCT uptake transporters: their role for drug-drug interactions and pharmacogenetic aspects.
Drug metabolism reviews 2010;42(3):380-401.
2010: Michaela E Kraft; Hartmut Glaeser; Kathrin Mandery; Jörg König; Daniel Auge; Martin F Fromm; Ursula Schlötzer-Schrehardt; Ulrich Welge-Lüssen; Friedrich E Kruse; Oliver Zolk
The prostaglandin transporter OATP2A1 is expressed in human ocular tissues and transports the antiglaucoma prostanoid latanoprost.
Investigative ophthalmology & visual science 2010;51(5):2504-11.
2010: Hartmut Glaeser; K Mandery; H Sticht; Martin F Fromm; Jörg König
Relevance of conserved lysine and arginine residues in transmembrane helices for the transport activity of organic anion transporting polypeptide 1B3.
British journal of pharmacology 2010;159(3):698-708.
2010: Ulrike Werner; Dierk Werner; Svetlana Heinbüchner; Bernhard Graf; Hüseyin Ince; Stefan Kische; Petra Thürmann; Jörg König; Martin F Fromm; Oliver Zolk
Gender is an important determinant of the disposition of the loop diuretic torasemide.
Journal of clinical pharmacology 2010;50(2):160-8.
2009: Iouri Bachmakov; Hartmut Glaeser; B Endress; F Mörl; Jörg König; Martin F Fromm
Interaction of beta-blockers with the renal uptake transporter OCT2.
Diabetes, obesity & metabolism 2009;11(11):1080-3.
2009: Oliver Zolk; Thomas F Solbach; Jörg König; Martin F Fromm
Functional characterization of the human organic cation transporter 2 variant p.270Ala>Ser.
Drug metabolism and disposition: the biological fate of chemicals 2009;37(6):1312-8.
2009: Jürgen Kindla; Martin F Fromm; Jörg König
In vitro evidence for the role of OATP and OCT uptake transporters in drug-drug interactions.
Expert opinion on drug metabolism & toxicology 2009;5(5):489-500.
2009: Oliver Zolk; Thomas F Solbach; Jörg König; Martin F Fromm
Structural determinants of inhibitor interaction with the human organic cation transporter OCT2 (SLC22A2).
Naunyn-Schmiedeberg's archives of pharmacology 2009;379(4):337-48.
2008: Iouri Bachmakov; Hartmut Glaeser; Martin F Fromm; Jörg König
Interaction of oral antidiabetic drugs with hepatic uptake transporters: focus on organic anion transporting polypeptides and organic cation transporter 1.
Diabetes 2008;57(6):1463-9.
2008: Annick Seithel; Kathrin Klein; Uli Zanger; Martin F Fromm; Jörg König
Non-synonymous polymorphisms in the human SLCO1B1 gene: an in vitro analysis of SNP c.1929A>C.
Molecular genetics and genomics : MGG 2008;279(2):149-57.
2008: Annick Seithel; Hartmut Glaeser; Martin F Fromm; Jörg König
The functional consequences of genetic variations in transporter genes encoding human organic anion-transporting polypeptide family members.
Expert opinion on drug metabolism & toxicology 2008;4(1):51-64.
2007: Martin F Fromm; Helmut Schwilden; Iouri Bachmakov; Jörg König; Frank Bremer; Jürgen Schüttler
Impact of the CYP3A5 genotype on midazolam pharmacokinetics and pharmacodynamics during intensive care sedation.
European journal of clinical pharmacology 2007;63(12):1129-33.
2007: Annick Seithel; Sonja Eberl; Katrin Singer; Daniel Auge; Georg Heinkele; Nadine B Wolf; Frank Dörje; Martin F Fromm; Jörg König
The influence of macrolide antibiotics on the uptake of organic anions and drugs mediated by OATP1B1 and OATP1B3.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(5):779-86.
2007: Ulrike Gradhand; Heike Tegude; Oliver Burk; Michel Eichelbaum; Martin F Fromm; Jörg König
Functional analysis of the polymorphism -211C>T in the regulatory region of the human ABCC3 gene.
Life sciences 2007;80(16):1490-4.
2007: Sonja Eberl; Bertold Renner; Antje Neubert; Mareike Reisig; Iouri Bachmakov; Jörg König; Frank Dörje; Thomas E Mürdter; Andreas Ackermann; Harald Dormann; Karl G Gassmann; Eckhart Hahn; Stefanie Zierhut; Kay Brune; Martin F Fromm
Role of p-glycoprotein inhibition for drug interactions: evidence from in vitro and pharmacoepidemiological studies.
Clinical pharmacokinetics 2007;46(12):1039-49.
2006: Jörg König; Annick Seithel; Ulrike Gradhand; Martin F Fromm
Pharmacogenomics of human OATP transporters.
Naunyn-Schmiedeberg's archives of pharmacology 2006;372(6):432-43.
2006: Thomas F Solbach; Jörg König; Martin F Fromm; Oliver Zolk
ATP-binding cassette transporters in the heart.
Trends in cardiovascular medicine 2006;16(1):7-15.