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William Konigsberg

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Linda J Reha-Krantz; Usharani Subuddhi; Shuangluo Xia; Chao Zhao; Jeff Beckman; Thomas Christian; Chithra Hariharan; William Konigsberg
Structure of the 2-aminopurine-cytosine base pair formed in the polymerase active site of the RB69 Y567A-DNA polymerase.
Shuangluo Xia; Mina Wang; Harold R Lee; Arjun Sinha; Gregor Blaha; Thomas Christian; Jimin Wang; William Konigsberg
Variation in mutation rates caused by RB69pol fidelity mutants can be rationalized on the basis of their kinetic behavior and crystal structures.
Graciela Krikun; Zhiwei Hu; Kevin G Osteen; Kaylon L Bruner-Tran; Frederick Schatz; Hugh S Taylor; Paolo Toti; Felice Arcuri; William Konigsberg; Alan Garen; Carmen J Booth; Charles J Lockwood
The immunoconjugate "icon" targets aberrantly expressed endothelial tissue factor causing regression of endometriosis.

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2011: Linda J Reha-Krantz; Usharani Subuddhi; Shuangluo Xia; Chao Zhao; Jeff Beckman; Thomas Christian; Chithra Hariharan; William Konigsberg
Structure of the 2-aminopurine-cytosine base pair formed in the polymerase active site of the RB69 Y567A-DNA polymerase.
Biochemistry 2011;50(46):10136-49.
2011: Shuangluo Xia; Mina Wang; Harold R Lee; Arjun Sinha; Gregor Blaha; Thomas Christian; Jimin Wang; William Konigsberg
Variation in mutation rates caused by RB69pol fidelity mutants can be rationalized on the basis of their kinetic behavior and crystal structures.
Journal of molecular biology 2011;406(4):558-70.
2010: Graciela Krikun; Zhiwei Hu; Kevin G Osteen; Kaylon L Bruner-Tran; Frederick Schatz; Hugh S Taylor; Paolo Toti; Felice Arcuri; William Konigsberg; Alan Garen; Carmen J Booth; Charles J Lockwood
The immunoconjugate "icon" targets aberrantly expressed endothelial tissue factor causing regression of endometriosis.
The American journal of pathology 2010;176(2):1050-6.
2009: Hong Zhang; Jeff Beckman; Jimin Wang; William Konigsberg
RB69 DNA polymerase mutants with expanded nascent base-pair-binding pockets are highly efficient but have reduced base selectivity.
Biochemistry 2009;48(29):6940-50.
2009: Mina Wang; Harold R Lee; William Konigsberg
Effect of A and B metal ion site occupancy on conformational changes in an RB69 DNA polymerase ternary complex.
Biochemistry 2009;48(10):2075-86.
2009: Harold R Lee; Mina Wang; William Konigsberg
The reopening rate of the fingers domain is a determinant of base selectivity for RB69 DNA polymerase.
Biochemistry 2009;48(10):2087-98.
2007: Hong Zhang; W Cao; E Zakharova; William Konigsberg; Enrique M De La Cruz
Fluorescence of 2-aminopurine reveals rapid conformational changes in the RB69 DNA polymerase-primer/template complexes upon binding and incorporation of matched deoxynucleoside triphosphates.
Nucleic acids research 2007;35(18):6052-62.
2006: Hong Zhang; Chanu Rhee; Anna Bebenek; John W Drake; Jimin Wang; William Konigsberg
The L561A substitution in the nascent base-pair binding pocket of RB69 DNA polymerase reduces base discrimination.
Biochemistry 2006;45(7):2211-20.
2005: Guangwei Yang; Jimin Wang; William Konigsberg
Base selectivity is impaired by mutants that perturb hydrogen bonding networks in the RB69 DNA polymerase active site.
Biochemistry 2005;44(9):3338-46.
2004: E Zakharova; Jimin Wang; William Konigsberg
The activity of selected RB69 DNA polymerase mutants can be restored by manganese ions: the existence of alternative metal ion ligands used during the polymerization cycle.
Biochemistry 2004;43(21):6587-95.
2004: C X Wang; E Zakharova; Jing Li; Catherine M Joyce; Jimin Wang; William Konigsberg
Pre-steady-state kinetics of RB69 DNA polymerase and its exo domain mutants: effect of pH and thiophosphoryl linkages on 3'-5' exonuclease activity.
Biochemistry 2004;43(13):3853-61.
2004: X Jiang; M A Bailly; Tracee S Panetti; Michael Cappello; William Konigsberg; Michael E Bromberg
Formation of tissue factor-factor VIIa-factor Xa complex promotes cellular signaling and migration of human breast cancer cells.
Journal of thrombosis and haemostasis : JTH 2004;2(1):93-101.
2002: Anna Bebenek; Geraldine T Carver; Holly Kloos Dressman; Farid A Kadyrov; Joseph K Haseman; Vasiliy Petrov; William Konigsberg; Jim D Karam; John W Drake
Dissecting the fidelity of bacteriophage RB69 DNA polymerase: site-specific modulation of fidelity by polymerase accessory proteins.
Genetics 2002;162(3):1003-18.
2002: Guangwei Yang; Matthew Franklin; Jing Li; TC Lin; William Konigsberg
A conserved Tyr residue is required for sugar selectivity in a Pol alpha DNA polymerase.
Biochemistry 2002;41(32):10256-61.
2002: Xu Song; Baiyang Wang; Michael E Bromberg; Zhiwei Hu; William Konigsberg; Alan Garen
Retroviral-mediated transmission of a mouse VL30 RNA to human melanoma cells promotes metastasis in an immunodeficient mouse model.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(9):6269-73.
2002: Guangwei Yang; Matthew Franklin; Jing Li; TC Lin; William Konigsberg
Correlation of the kinetics of finger domain mutants in RB69 DNA polymerase with its structure.
Biochemistry 2002;41(8):2526-34.
2001: Michael E Bromberg; M A Bailly; William Konigsberg
Role of protease-activated receptor 1 in tumor metastasis promoted by tissue factor.
Thrombosis and haemostasis 2001;86(5):1210-4.
2001: William Konigsberg; Daniel Kirchhofer; Markus A Riederer; Yale Nemerson
The TF:VIIa complex: clinical significance, structure-function relationships and its role in signaling and metastasis.
Thrombosis and haemostasis 2001;86(3):757-71.
2001: TC Lin; C X Wang; Catherine M Joyce; William Konigsberg
3'-5' Exonucleolytic activity of DNA polymerases: structural features that allow kinetic discrimination between ribo- and deoxyribonucleotide residues.
Biochemistry 2001;40(30):8749-55.
2001: Anna Bebenek; Holly Kloos Dressman; Geraldine T Carver; S Ng ; Vasiliy Petrov; G Yang; William Konigsberg; Jim D Karam; John W Drake
Interacting fidelity defects in the replicative DNA polymerase of bacteriophage RB69.
The Journal of biological chemistry 2001;276(13):10387-97.
2000: Jim D Karam; William Konigsberg
DNA polymerase of the T4-related bacteriophages.
Progress in nucleic acid research and molecular biology 2000;64():65-96.
1999: Michael E Bromberg; R Sundaram; R J Homer; Alan Garen; William Konigsberg
Role of tissue factor in metastasis: functions of the cytoplasmic and extracellular domains of the molecule.
Thrombosis and haemostasis 1999;82(1):88-92.
1999: Guangwei Yang; T Lin; Jim D Karam; William Konigsberg
Steady-state kinetic characterization of RB69 DNA polymerase mutants that affect dNTP incorporation.
Biochemistry 1999;38(25):8094-101.
1998: K M Donnelly; Michael E Bromberg; AARON MILSTONE; J M Madison McNiff; Gordon A Terwilliger; William Konigsberg; Michael Cappello
Ancylostoma caninum anticoagulant peptide blocks metastasis in vivo and inhibits factor Xa binding to melanoma cells in vitro.
Thrombosis and haemostasis 1998;79(5):1041-7.
1997: L D Goodrich; T C Lin; Eleanor K Spicer; C Jones; William Konigsberg
Residues at the carboxy terminus of T4 DNA polymerase are important determinants for interaction with the polymerase accessory proteins.
Biochemistry 1997;36(34):10474-81.
1997: Jimin Wang; A K Sattar; C C Wang; Jim D Karam; William Konigsberg; Thomas A Steitz
Crystal structure of a pol alpha family replication DNA polymerase from bacteriophage RB69.
Cell 1997;89(7):1087-99.
1996: A K Abdus Sattar; T C Lin; C Jones; William Konigsberg
Functional consequences and exonuclease kinetic parameters of point mutations in bacteriophage T4 DNA polymerase.
Biochemistry 1996;35(51):16621-9.
1996: C H Fang; T C Lin; A Guha; Y Nemerson; William Konigsberg
Activation of factor X by factor VIIa complexed with human-mouse tissue factor chimeras requires human exon 3.
Thrombosis and haemostasis 1996;76(3):361-8.
1996: J Wang; P Yu; T C Lin; William Konigsberg; Thomas A Steitz
Crystal structures of an NH2-terminal fragment of T4 DNA polymerase and its complexes with single-stranded DNA and with divalent metal ions.
Biochemistry 1996;35(25):8110-9.
1995: Michael E Bromberg; William Konigsberg; J F Madison; A Pawashe; Alan Garen
Tissue factor promotes melanoma metastasis by a pathway independent of blood coagulation.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(18):8205-9.
1995: Yousif Shamoo; Alan Friedman; M R Parsons; William Konigsberg; Thomas A Steitz
Crystal structure of a replication fork single-stranded DNA binding protein (T4 gp32) complexed to DNA.
Nature 1995;376(6538):362-6.
1995: William Konigsberg
Limited proteolysis of DNA polymerases as probe of functional domains.
Methods in enzymology 1995;262():331-46.
1994: T C Lin; G Karam; William Konigsberg
Isolation, characterization, and kinetic properties of truncated forms of T4 DNA polymerase that exhibit 3'-5' exonuclease activity.
The Journal of biological chemistry 1994;269(30):19286-94.
1994: T Hu; R R Bach; R Horton; William Konigsberg; M B Todd
Procoagulant activity in cancer cells is dependent on tissue factor expression.
Oncology research 1994;6(7):321-7.
1993: T Hu; R R Bach; R Horton; William Konigsberg; M B Todd
Synthesis of tissue factor messenger RNA and procoagulant activity in breast cancer cells in response to serum stimulation.
Thrombosis research 1993;72(2):155-68.
1993: Yousif Shamoo; A Tam; William Konigsberg; Kenneth R Williams
Translational repression by the bacteriophage T4 gene 32 protein involves specific recognition of an RNA pseudoknot structure.
Journal of molecular biology 1993;232(1):89-104.
1992: K R Webster; S Keill; William Konigsberg; Kenneth R Williams; Eleanor K Spicer
Identification of amino acid residues at the interface of a bacteriophage T4 regA protein-nucleic acid complex.
The Journal of biological chemistry 1992;267(36):26097-103.
1992: E Waxman; J B Alexander Ross; Thomas M Laue; A Guha; S V Thiruvikraman; T C Lin; William Konigsberg; Yale Nemerson
Tissue factor and its extracellular soluble domain: the relationship between intermolecular association with factor VIIa and enzymatic activity of the complex.
Biochemistry 1992;31(16):3998-4003.
1991: K R Webster; Yousif Shamoo; William Konigsberg; Eleanor K Spicer
A rapid method for purification of synthetic oligoribonucleotides.
BioTechniques 1991;11(5):658-61.
1991: A Pawashe; M Ezekowitz; T C Lin; R Horton; R Bach; William Konigsberg
Molecular cloning, characterization and expression of cDNA for rabbit brain tissue factor.
Thrombosis and haemostasis 1991;66(3):315-20.
1991: Yousif Shamoo; K R Webster; Kenneth R Williams; William Konigsberg
A retrovirus-like zinc domain is essential for translational repression of bacteriophage T4 gene 32.
The Journal of biological chemistry 1991;266(13):7967-70.
1991: Linda J Reha-Krantz; S Stocki; R L Nonay; E Dimayuga; L D Goodrich; William Konigsberg; Eleanor K Spicer
DNA polymerization in the absence of exonucleolytic proofreading: in vivo and in vitro studies.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(6):2417-21.
1990: J Rush; William Konigsberg
Photoaffinity labeling of the Klenow fragment with 8-azido-dATP.
The Journal of biological chemistry 1990;265(9):4821-7.
1989: Yousif Shamoo; L R Ghosaini; K M Keating; Kenneth R Williams; Julian M Sturtevant; William Konigsberg
Site-specific mutagenesis of T4 gene 32: the role of tyrosine residues in protein-nucleic acid interactions.
Biochemistry 1989;28(18):7409-17.
1989: J Rush; T C Lin; M Quinones; Eleanor K Spicer; I Douglas; Kenneth R Williams; William Konigsberg
The 44P subunit of the T4 DNA polymerase accessory protein complex catalyzes ATP hydrolysis.
The Journal of biological chemistry 1989;264(19):10943-53.
1989: L J Bloem; L Chen; William Konigsberg; R Bach
Serum stimulation of quiescent human fibroblasts induces the synthesis of tissue factor mRNA followed by the appearance of tissue factor antigen and procoagulant activity.
Journal of cellular physiology 1989;139(2):418-23.
1989: J Rush; William Konigsberg
Rapid purification of overexpressed T4 DNA polymerase.
Preparative biochemistry 1989;19(4):329-40.
1988: Eleanor K Spicer; J Rush; C Fung; Linda J Reha-Krantz; J D Karam; William Konigsberg
Primary structure of T4 DNA polymerase. Evolutionary relatedness to eucaryotic and other procaryotic DNA polymerases.
The Journal of biological chemistry 1988;263(16):7478-86.
1988: Yousif Shamoo; Kenneth R Williams; William Konigsberg
Photochemical crosslinking of bacteriophage T4 single-stranded DNA-binding protein (gp32) to oligo-p(dT)8: identification of phenylalanine-183 as the site of crosslinking.
Proteins 1988;4(1):1-6.
1987: T C Lin; J Rush; Eleanor K Spicer; William Konigsberg
Cloning and expression of T4 DNA polymerase.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(20):7000-4.
1987: Eleanor K Spicer; R Horton; L Bloem; R Bach; Kenneth R Williams; A Guha; J Kraus; T C Lin; Y Nemerson; William Konigsberg
Isolation of cDNA clones coding for human tissue factor: primary structure of the protein and cDNA.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(15):5148-52.
1986: Yousif Shamoo; H Adari; William Konigsberg; Kenneth R Williams; J W Chase
Cloning of T4 gene 32 and expression of the wild-type protein under lambda promoter PL regulation in Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(23):8844-8.
1986: D P Giedroc; K M Keating; Kenneth R Williams; William Konigsberg; JE Coleman
Gene 32 protein, the single-stranded DNA binding protein from bacteriophage T4, is a zinc metalloprotein.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(22):8452-6.
1986: R V Prigodich; Yousif Shamoo; Kenneth R Williams; J W Chase; William Konigsberg; JE Coleman
1H NMR (500 MHz) identification of aromatic residues of gene 32 protein involved in DNA binding by use of protein containing perdeuterated aromatic residues and by site-directed mutagenesis.
Biochemistry 1986;25(12):3666-72.
1986: JE Coleman; Kenneth R Williams; G C King; R V Prigodich; Yousif Shamoo; William Konigsberg
Protein chemistry-nuclear magnetic resonance approach to mapping functional domains in single-stranded DNA binding proteins.
Journal of cellular biochemistry 1986;32(4):305-26.
1985: H Y Adari; K Rose; Kenneth R Williams; William Konigsberg; T C Lin; Eleanor K Spicer
Cloning, nucleotide sequence, and overexpression of the bacteriophage T4 regA gene.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(7):1901-5.
1984: B M Merrill; Kenneth R Williams; J W Chase; William Konigsberg
Photochemical cross-linking of the Escherichia coli single-stranded DNA-binding protein to oligodeoxynucleotides. Identification of phenylalanine 60 as the site of cross-linking.
The Journal of biological chemistry 1984;259(17):10850-6.
1984: R V Prigodich; Jose R Casas-Finet; Kenneth R Williams; William Konigsberg; JE Coleman
1H NMR (500 MHz) of gene 32 protein--oligonucleotide complexes.
Biochemistry 1984;23(3):522-9.
1982: Eleanor K Spicer; J A Noble; N G Nossal; William Konigsberg; Kenneth R Williams
Bacteriophage T4 gene 45. Sequences of the structural gene and its protein product.
The Journal of biological chemistry 1982;257(15):8972-9.
1981: L O Sillerud; James H Prestegard; Robert K Yu; William Konigsberg; D E Schafer
Observation by 13C NMR of interactions between cholera toxin and the oligosaccharide of ganglioside GM1.
The Journal of biological chemistry 1981;256(3):1094-7.
1981: R A Grant; T C Lin; William Konigsberg; R E Webster
Structure of the filamentous bacteriophage fl. Location of the A, C, and D minor coat proteins.
The Journal of biological chemistry 1981;256(1):539-46.
1981: R A Grant; T C Lin; R E Webster; William Konigsberg
Structure of filamentous bacteriophage: isolation, characterization, and localization of the minor coat proteins and orientation of the DNA.
Progress in clinical and biological research 1981;64():413-28.
1981: Eleanor K Spicer; W M Kavanaugh; W S Dallas; S Falkow; William Konigsberg; D E Schafer
Sequence homologies between A subunits of Escherichia coli and Vibrio cholerae enterotoxins.
Proceedings of the National Academy of Sciences of the United States of America 1981;78(1):50-4.
1981: Kenneth R Williams; William Konigsberg
DNA helix-destabilizing proteins.
Gene amplification and analysis 1981;2():475-508.
1980: T C Lin; R E Webster; William Konigsberg
Isolation and characterization of the C and D proteins coded by gene IX and gene VI in the filamentous bacteriophage fl and fd.
The Journal of biological chemistry 1980;255(21):10331-7.