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Michael Konstan
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Network (preview)
15
Davis, Pamela
12
Wagener, Jeffrey
11
Morgan, Wayne
10
Chmiel, James
10
Berger, Melvin
8
Butler, Steven
8
Johnson, Charles
6
Ramsey, Bonnie
6
Schluchter, Mark
6
Wohl, Mary Ellen
5
Regelmann, Warren
5
Milgram, Laura
5
Bonfield, Tracey
5
Aitken, Moira
5
Drumm, Mitchell
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Geonetwork of Michael Konstan (preview)
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All Publications
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2009: Schechter Michael S; McColley Susanna A; Silva Stefanie; Haselkorn Tmirah; Konstan Michael W; Wagener Jeffrey S;
Association of socioeconomic status with the use of chronic therapies and healthcare utilization in children with cystic fibrosis.
The Journal of pediatrics 2009;155(5):634-9.e1-4.
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2009: Ashlock Melissa A; Beall Robert J; Hamblett Nicole M; Konstan Michael W; Penland Christopher M; Ramsey Bonnie W; Van Dalfsen Jill M; Wetmore Diana R; Campbell Preston W
A pipeline of therapies for cystic fibrosis.
Seminars in respiratory and critical care medicine 2009;30(5):611-26.
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2009: Konstan Michael W; Wagener Jeffrey S; VanDevanter Donald R
Characterizing aggressiveness and predicting future progression of CF lung disease.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 2009;8 Suppl 1():S15-9.
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2009: Ross Kristie R; Chmiel James F; Konstan Michael W
The role of inhaled corticosteroids in the management of cystic fibrosis.
Paediatric drugs 2009;11(2):101-13.
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2008: Ren Clement L; Pasta David J; Rasouliyan Lawrence; Wagener Jeffrey S; Konstan Michael W; Morgan Wayne J;
Relationship between inhaled corticosteroid therapy and rate of lung function decline in children with cystic fibrosis.
The Journal of pediatrics 2008;153(6):746-51.
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2008: Nichols David P; Konstan Michael W; Chmiel James F
Anti-inflammatory therapies for cystic fibrosis-related lung disease.
Clinical reviews in allergy & immunology 2008;35(3):135-53.
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2008: Konstan Michael W
Ibuprofen therapy for cystic fibrosis lung disease: revisited.
Current opinion in pulmonary medicine 2008;14(6):567-73.
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2008: Moskowitz Samuel M; Silva Stefanie J; Mayer-Hamblett Nicole; Pasta David J; Mink David R; Mabie Jenny A; Konstan Michael W; Wagener Jeffrey S;
Shifting patterns of inhaled antibiotic use in cystic fibrosis.
Pediatric pulmonology 2008;43(9):874-81.
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2008: VanDevanter Donald R; Rasouliyan Lawrence; Murphy Thomas M; Morgan Wayne J; Ren Clement L; Konstan Michael W; Wagener Jeffrey S;
Trends in the clinical characteristics of the U.S. cystic fibrosis patient population from 1995 to 2005.
Pediatric pulmonology 2008;43(8):739-44.
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2007: Konstan Michael W; Schluchter Mark D; Xue Wei; Davis Pamela B
Clinical use of Ibuprofen is associated with slower FEV1 decline in children with cystic fibrosis.
American journal of respiratory and critical care medicine 2007;176(11):1084-9.
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2007: Sagel Scott D; Chmiel James F; Konstan Michael W
Sputum biomarkers of inflammation in cystic fibrosis lung disease.
Proceedings of the American Thoracic Society 2007;4(4):406-17.
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2007: Konstan Michael W; Morgan Wayne J; Butler Steven M; Pasta David J; Craib Marcia L; Silva Stefanie J; Stokes Dennis C; Wohl Mary Ellen B; Wagener Jeffrey S; Regelmann Warren E; Johnson Charles A;
Risk factors for rate of decline in forced expiratory volume in one second in children and adolescents with cystic fibrosis.
The Journal of pediatrics 2007;151(2):134-9, 139.e1.
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2007: Gibson Ronald L; Emerson Julia; Mayer-Hamblett Nicole; Burns Jane L; McNamara Sharon; Accurso Frank J; Konstan Michael W; Chatfield Barbara A; Retsch-Bogart George; Waltz David A; Acton James; Zeitlin Pamela; Hiatt Peter; Moss Richard; Williams Judy; Ramsey Bonnie W
Duration of treatment effect after tobramycin solution for inhalation in young children with cystic fibrosis.
Pediatric pulmonology 2007;42(7):610-23.
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2007: Ren Clement L; Morgan Wayne J; Konstan Michael W; Schechter Michael S; Wagener Jeffrey S; Fisher Kathryn A; Regelmann Warren E;
Presence of methicillin resistant Staphylococcus aureus in respiratory cultures from cystic fibrosis patients is associated with lower lung function.
Pediatric pulmonology 2007;42(6):513-8.
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2007: Chmiel James F; Konstan Michael W
Inflammation and anti-inflammatory therapies for cystic fibrosis.
Clinics in chest medicine 2007;28(2):331-46.
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2007: Geller David E; Konstan Michael W; Smith Jeffrey; Noonberg Sarah B; Conrad Carol
Novel tobramycin inhalation powder in cystic fibrosis subjects: pharmacokinetics and safety.
Pediatric pulmonology 2007;42(4):307-13.
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2007: Mayer-Hamblett Nicole; Aitken Moira L; Accurso Frank J; Kronmal Richard A; Konstan Michael W; Burns Jane L; Sagel Scott D; Ramsey Bonnie W
Association between pulmonary function and sputum biomarkers in cystic fibrosis.
American journal of respiratory and critical care medicine 2007;175(8):822-8.
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2007: Padman Raj; McColley Susanna A; Miller Dave P; Konstan Michael W; Morgan Wayne J; Schechter Michael S; Ren Clement L; Wagener Jeffrey S;
Infant care patterns at epidemiologic study of cystic fibrosis sites that achieve superior childhood lung function.
Pediatrics 2007;119(3):e531-7.
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2006: Borowitz Drucy; Goss Christopher H; Limauro Stacey; Konstan Michael W; Blake Kathryn; Casey Susan; Quittner Alexandra L; Murray Frederick T
Study of a novel pancreatic enzyme replacement therapy in pancreatic insufficient subjects with cystic fibrosis.
The Journal of pediatrics 2006;149(5):658-662.
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2006: Schluchter Mark D; Konstan Michael W; Drumm Mitchell L; Yankaskas James R; Knowles Michael R
Classifying severity of cystic fibrosis lung disease using longitudinal pulmonary function data.
American journal of respiratory and critical care medicine 2006;174(7):780-6.
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2006: Borowitz Drucy; Goss Christopher H; Stevens Christopher; Hayes Denise; Newman Laurie; O'Rourke Anna; Konstan Michael W; Wagener Jeffrey; Moss Richard; Hendeles Leslie; Orenstein David; Ahrens Richard; Oermann Christopher M; Aitken Moira L; Mahl Thomas C; Young K Randall; Dunitz Jordan; Murray Frederick T
Safety and preliminary clinical activity of a novel pancreatic enzyme preparation in pancreatic insufficient cystic fibrosis patients.
Pancreas 2006;32(3):258-63.
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2006: McMullen Ann H; Pasta David J; Frederick Paul D; Konstan Michael W; Morgan Wayne J; Schechter Michael S; Wagener Jeffrey S
Impact of pregnancy on women with cystic fibrosis.
Chest 2006;129(3):706-11.
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2005: Blumer Jeffrey L; Saiman Lisa; Konstan Michael W; Melnick David
The efficacy and safety of meropenem and tobramycin vs ceftazidime and tobramycin in the treatment of acute pulmonary exacerbations in patients with cystic fibrosis.
Chest 2005;128(4):2336-46.
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2005: Drumm Mitchell L; Konstan Michael W; Schluchter Mark D; Handler Allison; Pace Rhonda; Zou Fei; Zariwala Maimoona; Fargo David; Xu Airong; Dunn John M; Darrah Rebecca J; Dorfman Ruslan; Sandford Andrew J; Corey Mary; Zielenski Julian; Durie Peter; Goddard Katrina; Yankaskas James R; Wright Fred A; Knowles Michael R;
Genetic modifiers of lung disease in cystic fibrosis.
The New England journal of medicine 2005;353(14):1443-53.
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2005: Hart Meeghan A; Konstan Michael W; Darrah Rebecca J; Schluchter Mark D; Storfer-Isser Amy; Xue Lintong; Londono Douglas; Goddard Katrina A B; Drumm Mitchell L
Beta 2 adrenergic receptor polymorphisms in cystic fibrosis.
Pediatric pulmonology 2005;39(6):544-50.
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2005: Chmiel James F; Konstan Michael W
Anti-inflammatory medications for cystic fibrosis lung disease: selecting the most appropriate agent.
Treatments in respiratory medicine 2005;4(4):255-73.
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2004: Konstan Michael W; Davis Pamela B; Wagener Jeffrey S; Hilliard Kathleen A; Stern Robert C; Milgram Laura J H; Kowalczyk Tomasz H; Hyatt Susannah L; Fink Tamara L; Gedeon Christopher R; Oette Sharon M; Payne Jennifer M; Muhammad Osman; Ziady Assem G; Moen Robert C; Cooper Mark J
Compacted DNA nanoparticles administered to the nasal mucosa of cystic fibrosis subjects are safe and demonstrate partial to complete cystic fibrosis transmembrane regulator reconstitution.
Human gene therapy 2004;15(12):1255-69.
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2004: Konstan M W; Stern R C; Trout J R; Sherman J M; Eigen H; Wagener J S; Duggan C; Wohl M E B; Colin P
Ultrase MT12 and Ultrase MT20 in the treatment of exocrine pancreatic insufficiency in cystic fibrosis: safety and efficacy.
Alimentary pharmacology & therapeutics 2004;20(11-12):1365-71.
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2004: Davis Pamela B; Schluchter Mark D; Konstan Michael W
Relation of sweat chloride concentration to severity of lung disease in cystic fibrosis.
Pediatric pulmonology 2004;38(3):204-9.
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2004: Rabin Harvey R; Butler Steven M; Wohl Mary Ellen B; Geller David E; Colin Andrew A; Schidlow Daniel V; Johnson Charles A; Konstan Michael W; Regelmann Warren E;
Pulmonary exacerbations in cystic fibrosis.
Pediatric pulmonology 2004;37(5):400-6.
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2004: Standaert Thomas A; Boitano Louis; Emerson Julia; Milgram Laura J H; Konstan Michael W; Hunter Janice; Berclaz Pierre-Yves; Brass Lois; Zeitlin Pamela L; Hammond Keith; Davies Zoe; Foy Carla; Noone Peadar G; Knowles Michael R
Standardized procedure for measurement of nasal potential difference: an outcome measure in multicenter cystic fibrosis clinical trials.
Pediatric pulmonology 2004;37(5):385-92.
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2003: Konstan Michael W; Krenicky Jeanne E; Finney Marcie R; Kirchner H Lester; Hilliard Kathleen A; Hilliard Jay B; Davis Pamela B; Hoppel Charles L
Effect of ibuprofen on neutrophil migration in vivo in cystic fibrosis and healthy subjects.
The Journal of pharmacology and experimental therapeutics 2003;306(3):1086-91.
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2003: Konstan Michael W; Butler Steven M; Wohl Mary Ellen B; Stoddard Marcia; Matousek Robert; Wagener Jeffrey S; Johnson Charles A; Morgan Wayne J;
Growth and nutritional indexes in early life predict pulmonary function in cystic fibrosis.
The Journal of pediatrics 2003;142(6):624-30.
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2003: Ziady Assem G; Davis Pamela B; Konstan Michael W
Non-viral gene transfer therapy for cystic fibrosis.
Expert opinion on biological therapy 2003;3(3):449-58.
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2003: Gibson Ronald L; Emerson Julia; McNamara Sharon; Burns Jane L; Rosenfeld Margaret; Yunker Ann; Hamblett Nicole; Accurso Frank; Dovey Mark; Hiatt Peter; Konstan Michael W; Moss Richard; Retsch-Bogart George; Wagener Jeffrey; Waltz David; Wilmott Robert; Zeitlin Pamela L; Ramsey Bonnie;
Significant microbiological effect of inhaled tobramycin in young children with cystic fibrosis.
American journal of respiratory and critical care medicine 2003;167(6):841-9.
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2003: Johnson Charles; Butler Steven M; Konstan Michael W; Morgan Wayne; Wohl Mary Ellen B
Factors influencing outcomes in cystic fibrosis: a center-based analysis.
Chest 2003;123(1):20-7.
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2002: Konstan Michael W; Davis Pamela B
Pharmacological approaches for the discovery and development of new anti-inflammatory agents for the treatment of cystic fibrosis.
Advanced drug delivery reviews 2002;54(11):1409-23.
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2002: Chmiel James F; Berger Melvin; Konstan Michael W
The role of inflammation in the pathophysiology of CF lung disease.
Clinical reviews in allergy & immunology 2002;23(1):5-27.
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2002: Schluchter Mark D; Konstan Michael W; Davis Pamela B
Jointly modelling the relationship between survival and pulmonary function in cystic fibrosis patients.
Statistics in medicine 2002;21(9):1271-87.
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2002: Chmiel James F; Konstan Michael W; Saadane Aicha; Krenicky Jeanne E; Lester Kirchner H; Berger Melvin
Prolonged inflammatory response to acute Pseudomonas challenge in interleukin-10 knockout mice.
American journal of respiratory and critical care medicine 2002;165(8):1176-81.
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2002: Ahrens Richard C; Standaert Thomas A; Launspach Janice; Han Seung-Ho; Teresi Mary E; Aitken Moira L; Kelley Thomas J; Hilliard Kathleen A; Milgram Laura J H; Konstan Michael W; Weatherly Mark R; McCarty Nael A
Use of nasal potential difference and sweat chloride as outcome measures in multicenter clinical trials in subjects with cystic fibrosis.
Pediatric pulmonology 2002;33(2):142-50.
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2002: McCarty Nael A; Standaert Thomas A; Teresi Mary; Tuthill Cynthia; Launspach Janice; Kelley Thomas J; Milgram Laura J H; Hilliard Kathleen A; Regelmann Warren E; Weatherly Mark R; Aitken Moira L; Konstan Michael W; Ahrens Richard C
A phase I randomized, multicenter trial of CPX in adult subjects with mild cystic fibrosis.
Pediatric pulmonology 2002;33(2):90-8.
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2002: Chmiel James F; Konstan Michael W; Berger Melvin
Murine models of CF airway infection and inflammation.
Methods in molecular medicine 2002;70():495-515.
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2002: Hilliard Jay B; Konstan Michael W; Davis Pamela B
Inflammatory mediators in CF patients.
Methods in molecular medicine 2002;70():409-31.
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2001: Quan J M; Tiddens H A; Sy J P; McKenzie S G; Montgomery M D; Robinson P J; Wohl M E; Konstan M W;
A two-year randomized, placebo-controlled trial of dornase alfa in young patients with cystic fibrosis with mild lung function abnormalities.
The Journal of pediatrics 2001;139(6):813-20.
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2001: Rosenfeld M; Gibson R; McNamara S; Emerson J; McCoyd K S; Shell R; Borowitz D; Konstan M W; Retsch-Bogart G; Wilmott R W; Burns J L; Vicini P; Montgomery A B; Ramsey B
Serum and lower respiratory tract drug concentrations after tobramycin inhalation in young children with cystic fibrosis.
The Journal of pediatrics 2001;139(4):572-7.
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2001: Noone P G; Hamblett N; Accurso F; Aitken M L; Boyle M; Dovey M; Gibson R; Johnson C; Kellerman D; Konstan M W; Milgram L; Mundahl J; Retsch-Bogort G; Rodman D; Williams-Warren J; Wilmott R W; Zeitlin P; Ramsey B;
Safety of aerosolized INS 365 in patients with mild to moderate cystic fibrosis: results of a phase I multi-center study.
Pediatric pulmonology 2001;32(2):122-8.
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2000: van Heeckeren A M; Tscheikuna J; Walenga R W; Konstan M W; Davis P B; Erokwu B; Haxhiu M A; Ferkol T W
Effect of Pseudomonas infection on weight loss, lung mechanics, and cytokines in mice.
American journal of respiratory and critical care medicine 2000;161(1):271-9.
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1999: Chmiel J F; Konstan M W; Knesebeck J E; Hilliard J B; Bonfield T L; Dawson D V; Berger M
IL-10 attenuates excessive inflammation in chronic Pseudomonas infection in mice.
American journal of respiratory and critical care medicine 1999;160(6):2040-7.
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1999: Konstan M W; Butler S M; Schidlow D V; Morgan W J; Julius J R; Johnson C A
Patterns of medical practice in cystic fibrosis: part II. Use of therapies. Investigators and Coordinators of the Epidemiologic Study of Cystic Fibrosis.
Pediatric pulmonology 1999;28(4):248-54.
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1999: Konstan M W; Butler S M; Schidlow D V; Morgan W J; Julius J R; Johnson C A
Patterns of medical practice in cystic fibrosis: part I. Evaluation and monitoring of health status of patients. Investigators and Coordinators of the Epidemiologic Study of Cystic Fibrosis.
Pediatric pulmonology 1999;28(4):242-7.
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1999: Morgan W J; Butler S M; Johnson C A; Colin A A; FitzSimmons S C; Geller D E; Konstan M W; Light M J; Rabin H R; Regelmann W E; Schidlow D V; Stokes D C; Wohl M E; Kaplowitz H; Wyatt M M; Stryker S
Epidemiologic study of cystic fibrosis: design and implementation of a prospective, multicenter, observational study of patients with cystic fibrosis in the U.S. and Canada.
Pediatric pulmonology 1999;28(4):231-41.
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1999: Bonfield T L; Konstan M W; Berger M
Altered respiratory epithelial cell cytokine production in cystic fibrosis.
The Journal of allergy and clinical immunology 1999;104(1):72-8.
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1999: Johnson C A; Butler S M; Konstan M W; Breen T J; Morgan W J
Estimating effectiveness in an observational study: a case study of dornase alfa in cystic fibrosis. The Investigators and Coordinators of the Epidemiologic Study of Cystic Fibrosis.
The Journal of pediatrics 1999;134(6):734-9.
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1999: Oermann C M; Sockrider M M; Konstan M W
The use of anti-inflammatory medications in cystic fibrosis: trends and physician attitudes.
Chest 1999;115(4):1053-8.
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1999: Chmiel J F; Drumm M L; Konstan M W; Ferkol T W; Kercsmar C M
Pitfall in the use of genotype analysis as the sole diagnostic criterion for cystic fibrosis.
Pediatrics 1999;103(4 Pt 1):823-6.
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1998: Konstan M W
Therapies aimed at airway inflammation in cystic fibrosis.
Clinics in chest medicine 1998;19(3):505-13, vi.
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1998: Ferkol T; Mularo F; Hilliard J; Lodish S; Perales J C; Ziady A; Konstan M
Transfer of the human Alpha1-antitrypsin gene into pulmonary macrophages in vivo.
American journal of respiratory cell and molecular biology 1998;18(5):591-601.
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1998: Geller D E; Eigen H; Fiel S B; Clark A; Lamarre A P; Johnson C A; Konstan M W
Effect of smaller droplet size of dornase alfa on lung function in mild cystic fibrosis. Dornase Alfa Nebulizer Group.
Pediatric pulmonology 1998;25(2):83-7.
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1997: Heeckeren A; Walenga R; Konstan M W; Bonfield T; Davis P B; Ferkol T
Excessive inflammatory response of cystic fibrosis mice to bronchopulmonary infection with Pseudomonas aeruginosa.
The Journal of clinical investigation 1997;100(11):2810-5.
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1997: Konstan M W; Berger M
Current understanding of the inflammatory process in cystic fibrosis: onset and etiology.
Pediatric pulmonology 1997;24(2):137-42; discussion 159-61.
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1997: Davis P B; Byard P J; Konstan M W
Identifying treatments that halt progression of pulmonary disease in cystic fibrosis.
Pediatric research 1997;41(2):161-5.
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1996: Davis P B; Drumm M; Konstan M W
Cystic fibrosis.
American journal of respiratory and critical care medicine 1996;154(5):1229-56.
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1995: Bonfield T L; Panuska J R; Konstan M W; Hilliard K A; Hilliard J B; Ghnaim H; Berger M
Inflammatory cytokines in cystic fibrosis lungs.
American journal of respiratory and critical care medicine 1995;152(6 Pt 1):2111-8.
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1995: Bonfield T L; Konstan M W; Burfeind P; Panuska J R; Hilliard J B; Berger M
Normal bronchial epithelial cells constitutively produce the anti-inflammatory cytokine interleukin-10, which is downregulated in cystic fibrosis.
American journal of respiratory cell and molecular biology 1995;13(3):257-61.
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1995: Tosi M F; Zakem-Cloud H; Demko C A; Schreiber J R; Stern R C; Konstan M W; Berger M
Cross-sectional and longitudinal studies of naturally occurring antibodies to Pseudomonas aeruginosa in cystic fibrosis indicate absence of antibody-mediated protection and decline in opsonic quality after infection.
The Journal of infectious diseases 1995;172(2):453-61.
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1995: Konstan M W; Byard P J; Hoppel C L; Davis P B
Effect of high-dose ibuprofen in patients with cystic fibrosis.
The New England journal of medicine 1995;332(13):848-54.
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1994: Konstan M W; Hilliard K A; Norvell T M; Berger M
Bronchoalveolar lavage findings in cystic fibrosis patients with stable, clinically mild lung disease suggest ongoing infection and inflammation.
American journal of respiratory and critical care medicine 1994;150(2):448-54.
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1994: Berger M; Norvell T M; Tosi M F; Emancipator S N; Konstan M W; Schreiber J R
Tissue-specific Fc gamma and complement receptor expression by alveolar macrophages determines relative importance of IgG and complement in promoting phagocytosis of Pseudomonas aeruginosa.
Pediatric research 1994;35(1):68-77.
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1993: Konstan M W; Walenga R W; Hilliard K A; Hilliard J B
Leukotriene B4 markedly elevated in the epithelial lining fluid of patients with cystic fibrosis.
The American review of respiratory disease 1993;148(4 Pt 1):896-901.
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1991: Konstan M W; Hoppel C L; Chai B L; Davis P B
Ibuprofen in children with cystic fibrosis: pharmacokinetics and adverse effects.
The Journal of pediatrics 1991;118(6):956-64.
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1990: Konstan M W; Vargo K M; Davis P B
Ibuprofen attenuates the inflammatory response to Pseudomonas aeruginosa in a rat model of chronic pulmonary infection. Implications for antiinflammatory therapy in cystic fibrosis.
The American review of respiratory disease 1990;141(1):186-92.
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