Konstantinos Konstantopoulos

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George Niraj Procopio Evagrio; Ymele-Leki Patrick; Konstantopoulos Konstantinos; Ross Julia Myers
Differential binding of biofilm-derived and suspension-grown Staphylococcus aureus to immobilized platelets in shear flow.
Thomas Susan N; Schnaar Ronald L; Konstantopoulos Konstantinos
Podocalyxin-like protein is an E-/L-selectin ligand on colon carcinoma cells: comparative biochemical properties of selectin ligands in host and tumor cells.
Alves Christina S; Yakovlev Sergiy; Medved Leonid; Konstantopoulos Konstantinos
Biomolecular characterization of CD44-fibrin(ogen) binding: distinct molecular requirements mediate binding of standard and variant isoforms of CD44 to immobilized fibrin(ogen).

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All Publications

2009: George Niraj Procopio Evagrio; Ymele-Leki Patrick; Konstantopoulos Konstantinos; Ross Julia Myers
Differential binding of biofilm-derived and suspension-grown Staphylococcus aureus to immobilized platelets in shear flow.
The Journal of infectious diseases 2009;199(5):633-40.
2009: Thomas Susan N; Schnaar Ronald L; Konstantopoulos Konstantinos
Podocalyxin-like protein is an E-/L-selectin ligand on colon carcinoma cells: comparative biochemical properties of selectin ligands in host and tumor cells.
American journal of physiology. Cell physiology 2009;296(3):C505-13.
2009: Alves Christina S; Yakovlev Sergiy; Medved Leonid; Konstantopoulos Konstantinos
Biomolecular characterization of CD44-fibrin(ogen) binding: distinct molecular requirements mediate binding of standard and variant isoforms of CD44 to immobilized fibrin(ogen).
The Journal of biological chemistry 2009;284(2):1177-89.
2009: Thomas Susan N; Tong Ziqiu; Stebe Kathleen J; Konstantopoulos Konstantinos
Identification, characterization and utilization of tumor cell selectin ligands in the design of colon cancer diagnostics.
Biorheology 2009;46(3):207-25.
2009: Konstantopoulos Konstantinos; Thomas Susan N
Cancer cells in transit: the vascular interactions of tumor cells.
Annual review of biomedical engineering 2009;11():177-202.
2008: Nimrichter Leonardo; Burdick Monica M; Aoki Kazuhiro; Laroy Wouter; Fierro Mark A; Hudson Sherry A; Von Seggern Christopher E; Cotter Robert J; Bochner Bruce S; Tiemeyer Michael; Konstantopoulos Konstantinos; Schnaar Ronald L
E-selectin receptors on human leukocytes.
Blood 2008;112(9):3744-52.
2008: Pawar Parag; Jadhav Sameer; Eggleton Charles D; Konstantopoulos Konstantinos
Roles of cell and microvillus deformation and receptor-ligand binding kinetics in cell rolling.
American journal of physiology. Heart and circulatory physiology 2008;295(4):H1439-50.
2008: Ghosh Moniraj; Alves Christina; Tong Ziqiu; Tettey Kwadwo; Konstantopoulos Konstantinos; Stebe Kathleen J
Multifunctional surfaces with discrete functionalized regions for biological applications.
Langmuir : the ACS journal of surfaces and colloids 2008;24(15):8134-42.
2008: Dikeman Dustin A; Rivera Rosado Leslie A; Horn Troy A; Alves Christina S; Konstantopoulos Konstantinos; Yang Joy T
alpha4 beta1-Integrin regulates directionally persistent cell migration in response to shear flow stimulation.
American journal of physiology. Cell physiology 2008;295(1):C151-9.
2008: Thomas Susan N; Zhu Fei; Schnaar Ronald L; Alves Christina S; Konstantopoulos Konstantinos
Carcinoembryonic antigen and CD44 variant isoforms cooperate to mediate colon carcinoma cell adhesion to E- and L-selectin in shear flow.
The Journal of biological chemistry 2008;283(23):15647-55.
2008: Healy Zachary R; Zhu Fei; Stull Joshua D; Konstantopoulos Konstantinos
Elucidation of the signaling network of COX-2 induction in sheared chondrocytes: COX-2 is induced via a Rac/MEKK1/MKK7/JNK2/c-Jun-C/EBPbeta-dependent pathway.
American journal of physiology. Cell physiology 2008;294(5):C1146-57.
2008: Alves Christina S; Burdick Monica M; Thomas Susan N; Pawar Parag; Konstantopoulos Konstantinos
The dual role of CD44 as a functional P-selectin ligand and fibrin receptor in colon carcinoma cell adhesion.
American journal of physiology. Cell physiology 2008;294(4):C907-16.
2008: Jaluria Pratik; Konstantopoulos Konstantinos; Betenbaugh Michael; Shiloach Joseph
Egr1 and Gas6 facilitate the adaptation of HEK-293 cells to serum-free media by conferring enhanced viability and higher growth rates.
Biotechnology and bioengineering 2008;99(6):1443-52.
2008: Dobrowsky Terrence M; Panorchan Porntula; Konstantopoulos Konstantinos; Wirtz Denis
Chapter 15: Live-cell single-molecule force spectroscopy.
Methods in cell biology 2008;89():411-32.
2007: George Niraj Procopio Evagrio; Konstantopoulos Konstantinos; Ross Julia Myers
Differential kinetics and molecular recognition mechanisms involved in early versus late growth phase Staphylococcus aureus cell binding to platelet layers under physiological shear conditions.
The Journal of infectious diseases 2007;196(4):639-46.
2007: Jaluria Pratik; Betenbaugh Michael; Konstantopoulos Konstantinos; Frank Bryan; Shiloach Joseph
Application of microarrays to identify and characterize genes involved in attachment dependence in HeLa cells.
Metabolic engineering 2007;9(3):241-51.
2007: Napier Susan L; Healy Zachary R; Schnaar Ronald L; Konstantopoulos Konstantinos
Selectin ligand expression regulates the initial vascular interactions of colon carcinoma cells: the roles of CD44v and alternative sialofucosylated selectin ligands.
The Journal of biological chemistry 2007;282(6):3433-41.
2007: Jaluria Pratik; Betenbaugh Michael; Konstantopoulos Konstantinos; Shiloach Joseph
Enhancement of cell proliferation in various mammalian cell lines by gene insertion of a cyclin-dependent kinase homolog.
BMC biotechnology 2007;7():71.
2007: Jadhav Sameer; Eggleton Charles D; Konstantopoulos Konstantinos
Mathematical modeling of cell adhesion in shear flow: application to targeted drug delivery in inflammation and cancer metastasis.
Current pharmaceutical design 2007;13(15):1511-26.
2007: Jadhav Sameer; Chan Kit Yan; Konstantopoulos Konstantinos; Eggleton Charles D
Shear modulation of intercellular contact area between two deformable cells colliding under flow.
Journal of biomechanics 2007;40(13):2891-7.
2007: Jaluria Pratik; Konstantopoulos Konstantinos; Betenbaugh Michael; Shiloach Joseph
A perspective on microarrays: current applications, pitfalls, and potential uses.
Microbial cell factories 2007;6():4.
2006: George Niraj Procopio Evagrio; Wei Qi; Shin Pyong Kyun; Konstantopoulos Konstantinos; Ross Julia M
Staphylococcus aureus adhesion via Spa, ClfA, and SdrCDE to immobilized platelets demonstrates shear-dependent behavior.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(10):2394-400.
2006: Lim Lina H K; Burdick Monica M; Hudson Sherry A; Mustafa Fatimah Bte; Konstantopoulos Konstantinos; Bochner Bruce S
Stimulation of human endothelium with IL-3 induces selective basophil accumulation in vitro.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(9):5346-53.
2006: Grazioli Alison; Alves Christina S; Konstantopoulos Konstantinos; Yang Joy T
Defective blood vessel development and pericyte/pvSMC distribution in alpha 4 integrin-deficient mouse embryos.
Developmental biology 2006;293(1):165-77.
2006: Hanley William D; Napier Susan L; Burdick Monica M; Schnaar Ronald L; Sackstein Robert; Konstantopoulos Konstantinos
Variant isoforms of CD44 are P- and L-selectin ligands on colon carcinoma cells.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(2):337-9.
2006: Panorchan Porntula; Thompson Melissa S; Davis Kelly J; Tseng Yiider; Konstantopoulos Konstantinos; Wirtz Denis
Single-molecule analysis of cadherin-mediated cell-cell adhesion.
Journal of cell science 2006;119(Pt 1):66-74.
2005: Healy Zachary R; Lee Norman H; Gao Xiangqun; Goldring Mary B; Talalay Paul; Kensler Thomas W; Konstantopoulos Konstantinos
Divergent responses of chondrocytes and endothelial cells to shear stress: cross-talk among COX-2, the phase 2 response, and apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(39):14010-5.
2005: Shin Pyong Kyun; Pawar Parag; Konstantopoulos Konstantinos; Ross Julia M
Characteristics of new Staphylococcus aureus-RBC adhesion mechanism independent of fibrinogen and IgG under hydrodynamic shear conditions.
American journal of physiology. Cell physiology 2005;289(3):C727-34.
2005: Hanley William D; Burdick Monica M; Konstantopoulos Konstantinos; Sackstein Robert
CD44 on LS174T colon carcinoma cells possesses E-selectin ligand activity.
Cancer research 2005;65(13):5812-7.
2005: Ahn Kyung C; Jun Andy J; Pawar Parag; Jadhav Sameer; Napier Susan; McCarty Owen J T; Konstantopoulos Konstantinos
Preferential binding of platelets to monocytes over neutrophils under flow.
Biochemical and biophysical research communications 2005;329(1):345-55.
2005: Jadhav Sameer; Eggleton Charles D; Konstantopoulos Konstantinos
A 3-D computational model predicts that cell deformation affects selectin-mediated leukocyte rolling.
Biophysical journal 2005;88(1):96-104.
2004: Burdick Monica M; Konstantopoulos Konstantinos
Platelet-induced enhancement of LS174T colon carcinoma and THP-1 monocytoid cell adhesion to vascular endothelium under flow.
American journal of physiology. Cell physiology 2004;287(2):C539-47.
2004: Pawar Parag; Shin Pyong Kyun; Mousa Shaker A; Ross Julia M; Konstantopoulos Konstantinos
Fluid shear regulates the kinetics and receptor specificity of Staphylococcus aureus binding to activated platelets.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(2):1258-65.
2004: Hanley William D; Wirtz Denis; Konstantopoulos Konstantinos
Distinct kinetic and mechanical properties govern selectin-leukocyte interactions.
Journal of cell science 2004;117(Pt 12):2503-11.
2004: McCarty Owen J T; Abulencia James P; Mousa Shaker A; Konstantopoulos Konstantinos
Evaluation of platelet antagonists in in vitro flow models of thrombosis.
Methods in molecular medicine 2004;93():21-34.
2003: Konstantopoulos Konstantinos; Hanley William D; Wirtz Denis
Receptor-ligand binding: 'catch' bonds finally caught.
Current biology : CB 2003;13(15):R611-3.
2003: Abulencia James P; Gaspard Renee; Healy Zachary R; Gaarde William A; Quackenbush John; Konstantopoulos Konstantinos
Shear-induced cyclooxygenase-2 via a JNK2/c-Jun-dependent pathway regulates prostaglandin receptor expression in chondrocytic cells.
The Journal of biological chemistry 2003;278(31):28388-94.
2003: McCarty Owen J T; Tien Niven; Bochner Bruce S; Konstantopoulos Konstantinos
Exogenous eosinophil activation converts PSGL-1-dependent binding to CD18-dependent stable adhesion to platelets in shear flow.
American journal of physiology. Cell physiology 2003;284(5):C1223-34.
2003: Burdick Monica M; McCaffery J Michael; Kim Young S; Bochner Bruce S; Konstantopoulos Konstantinos
Colon carcinoma cell glycolipids, integrins, and other glycoproteins mediate adhesion to HUVECs under flow.
American journal of physiology. Cell physiology 2003;284(4):C977-87.
2003: Hanley William; McCarty Owen; Jadhav Sameer; Tseng Yiider; Wirtz Denis; Konstantopoulos Konstantinos
Single molecule characterization of P-selectin/ligand binding.
The Journal of biological chemistry 2003;278(12):10556-61.
2002: Jadhav Sameer; Konstantopoulos Konstantinos
Fluid shear- and time-dependent modulation of molecular interactions between PMNs and colon carcinomas.
American journal of physiology. Cell physiology 2002;283(4):C1133-43.
2002: McCarty Owen J T; Jadhav Sameer; Burdick Monica M; Bell William R; Konstantopoulos Konstantinos
Fluid shear regulates the kinetics and molecular mechanisms of activation-dependent platelet binding to colon carcinoma cells.
Biophysical journal 2002;83(2):836-48.
2002: Mousa Shaker A; Abulencia James P; McCarty Owen J T; Turner Nancy A; Konstantopoulos Konstantinos
Comparative efficacy between the glycoprotein IIb/IIIa antagonists roxifiban and orbofiban in inhibiting platelet responses in flow models of thrombosis.
Journal of cardiovascular pharmacology 2002;39(4):552-60.
2001: Jadhav S; Bochner B S; Konstantopoulos K
Hydrodynamic shear regulates the kinetics and receptor specificity of polymorphonuclear leukocyte-colon carcinoma cell adhesive interactions.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(10):5986-93.
2001: Konstantopoulos K; Mousa S A
Antiplatelet therapies: platelet GPIIb/IIIa antagonists and beyond.
Current opinion in investigational drugs (London, England : 2000) 2001;2(8):1086-92.
2001: Burdick M M; Bochner B S; Collins B E; Schnaar R L; Konstantopoulos K
Glycolipids support E-selectin-specific strong cell tethering under flow.
Biochemical and biophysical research communications 2001;284(1):42-9.
2001: Burdick M M; McCarty O J; Jadhav S; Konstantopoulos K
Cell-cell interactions in inflammation and cancer metastasis.
IEEE engineering in medicine and biology magazine : the quarterly magazine of the Engineering in Medicine & Biology Society 2001;20(3):86-91.
2001: Abulencia J P; Tien N; McCarty O J; Plymire D; Mousa S A; Konstantopoulos K
Comparative antiplatelet efficacy of a novel, nonpeptide GPIIb/IIIa antagonist (XV454) and abciximab (c7E3) in flow models of thrombosis.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(1):149-56.
2000: McCarty O J; Mousa S A; Bray P F; Konstantopoulos K
Immobilized platelets support human colon carcinoma cell tethering, rolling, and firm adhesion under dynamic flow conditions.
Blood 2000;96(5):1789-97.
2000: Tachimoto H; Burdick M M; Hudson S A; Kikuchi M; Konstantopoulos K; Bochner B S
CCR3-active chemokines promote rapid detachment of eosinophils from VCAM-1 in vitro.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(5):2748-54.
1999: Papadimitriou M N; Menter D G; Konstantopoulos K; Nicolson G L; McIntire L V
Integrin alpha4beta1/VCAM-1 pathway mediates primary adhesion of RAW117 lymphoma cells to hepatic sinusoidal endothelial cells under flow.
Clinical & experimental metastasis 1999;17(8):669-76.
1998: Konstantopoulos K; Neelamegham S; Burns A R; Hentzen E; Kansas G S; Snapp K R; Berg E L; Hellums J D; Smith C W; McIntire L V; Simon S I
Venous levels of shear support neutrophil-platelet adhesion and neutrophil aggregation in blood via P-selectin and beta2-integrin.
Circulation 1998;98(9):873-82.
1998: Konstantopoulos K; Kukreti S; McIntire L V
Biomechanics of cell interactions in shear fields.
Advanced drug delivery reviews 1998;33(1-2):141-64.
1997: Konstantopoulos K; McIntire L V
Effects of fluid dynamic forces on vascular cell adhesion.
The Journal of clinical investigation 1997;100(11 Suppl):S19-23.
1997: Kukreti S; Konstantopoulos K; Smith C W; McIntire L V
Molecular mechanisms of monocyte adhesion to interleukin-1beta-stimulated endothelial cells under physiologic flow conditions.
Blood 1997;89(11):4104-11.
1997: Kamat S G; Turner N A; Konstantopoulos K; Hellums J D; McIntire L V; Kleiman N S; Moake J L
Effects of Integrelin on platelet function in flow models of arterial thrombosis.
Journal of cardiovascular pharmacology 1997;29(2):156-63.
1997: Konstantopoulos K; Kukreti S; Smith C W; McIntire L V
Endothelial P-selectin and VCAM-1 each can function as primary adhesive mechanisms for T cells under conditions of flow.
Journal of leukocyte biology 1997;61(2):179-87.
1997: Konstantopoulos K; Chow T W; Turner N A; Hellums J D; Moake J L
Shear stress-induced binding of von Willebrand factor to platelets.
Biorheology 1997;34(1):57-71.
1996: Konstantopoulos K; McIntire L V
Effects of fluid dynamic forces on vascular cell adhesion.
The Journal of clinical investigation 1996;98(12):2661-5.
1995: Konstantopoulos K; Grotta J C; Sills C; Wu K K; Hellums J D
Shear-induced platelet aggregation in normal subjects and stroke patients.
Thrombosis and haemostasis 1995;74(5):1329-34.
1995: Konstantopoulos K; Kamat S G; Schafer A I; Bañez E I; Jordan R; Kleiman N S; Hellums J D
Shear-induced platelet aggregation is inhibited by in vivo infusion of an anti-glycoprotein IIb/IIIa antibody fragment, c7E3 Fab, in patients undergoing coronary angioplasty.
Circulation 1995;91(5):1427-31.
1995: Konstantopoulos K; Wu K K; Udden M M; Bañez E I; Shattil S J; Hellums J D
Flow cytometric studies of platelet responses to shear stress in whole blood.
Biorheology 1995;32(1):73-93.

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Konstantinos Konstantopoulos

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