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George Koob

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Operant Conditioning

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Co-Publications
Name
38
Markou, Athina
33
Weiss, Friedbert
29
Zorrilla, Eric
26
Heinrichs, Stephen
24
Schulteis, Gery
23
Gold, Lisa
22
Stinus, Luis
22
Pulvirenti, Luigi
21
Roberts, Amanda
21
Britton, KT
19
Parsons, Loren
18
O'Dell, Laura
15
Heyser, Charles
14
Ahmed, Serge
14
Richardson, Heather

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Publications

TOP 3
Roberto Marisa; Koob George F
First Congress of "Alcoholism and stress: a framework for future treatment strategies": Introduction to the proceeding.
Francesconi Walter; Berton Fulvia; Koob George F; Sanna Pietro Paolo
Intrinsic neuronal plasticity in the juxtacapsular nucleus of the bed nuclei of the stria terminalis (jcBNST).
Richardson Heather N; Chan Stephanie H; Crawford Elena F; Lee Youn Kyung; Funk Cindy K; Koob George F; Mandyam Chitra D
Permanent impairment of birth and survival of cortical and hippocampal proliferating cells following excessive drinking during alcohol dependence.

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All Publications

2009: Roberto Marisa; Koob George F
First Congress of "Alcoholism and stress: a framework for future treatment strategies": Introduction to the proceeding.
Alcohol (Fayetteville, N.Y.) 2009;43(7):489-90.
2009: Francesconi Walter; Berton Fulvia; Koob George F; Sanna Pietro Paolo
Intrinsic neuronal plasticity in the juxtacapsular nucleus of the bed nuclei of the stria terminalis (jcBNST).
Progress in neuro-psychopharmacology & biological psychiatry 2009;33(8):1347-55.
2009: Richardson Heather N; Chan Stephanie H; Crawford Elena F; Lee Youn Kyung; Funk Cindy K; Koob George F; Mandyam Chitra D
Permanent impairment of birth and survival of cortical and hippocampal proliferating cells following excessive drinking during alcohol dependence.
Neurobiology of disease 2009;36(1):1-10.
2009: Koob George F
Brain stress systems in the amygdala and addiction.
Brain research 2009;1293():61-75.
2009: Wee Sunmee; Orio Laura; Ghirmai Senait; Cashman John R; Koob George F
Inhibition of kappa opioid receptors attenuated increased cocaine intake in rats with extended access to cocaine.
Psychopharmacology 2009;205(4):565-75.
2009: Sabino Valentina; Cottone Pietro; Zhao Yu; Steardo Luca; Koob George F; Zorrilla Eric P
Selective reduction of alcohol drinking in Sardinian alcohol-preferring rats by a sigma-1 receptor antagonist.
Psychopharmacology 2009;205(2):327-35.
2009: Koob George F; Kenneth Lloyd G; Mason Barbara J
Development of pharmacotherapies for drug addiction: a Rosetta stone approach.
Nature reviews. Drug discovery 2009;8(6):500-15.
2009: Koob G F
Dynamics of neuronal circuits in addiction: reward, antireward, and emotional memory.
Pharmacopsychiatry 2009;42 Suppl 1():S32-41.
2009: Sabino Valentina; Cottone Pietro; Zhao Yu; Iyer Malliga R; Steardo Luca; Steardo Luca; Rice Kenner C; Conti Bruno; Koob George F; Zorrilla Eric P
The sigma-receptor antagonist BD-1063 decreases ethanol intake and reinforcement in animal models of excessive drinking.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2009;34(6):1482-93.
2009: Francesconi Walter; Berton Fulvia; Repunte-Canonigo Vez; Hagihara Kazuki; Thurbon David; Lekic Dusan; Specio Sheila E; Greenwell Thomas N; Chen Scott A; Rice Kenner C; Richardson Heather N; O'Dell Laura E; Zorrilla Eric P; Morales Marisela; Koob George F; Sanna Pietro Paolo
Protracted withdrawal from alcohol and drugs of abuse impairs long-term potentiation of intrinsic excitability in the juxtacapsular bed nucleus of the stria terminalis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(17):5389-401.
2009: Orio Laura; Edwards Scott; George Olivier; Parsons Loren H; Koob George F
A role for the endocannabinoid system in the increased motivation for cocaine in extended-access conditions.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(15):4846-57.
2009: Greenwell Thomas N; Funk Cindy K; Cottone Pietro; Richardson Heather N; Chen Scott A; Rice Kenner C; Zorrilla Eric P; Koob George F
Corticotropin-releasing factor-1 receptor antagonists decrease heroin self-administration in long- but not short-access rats.
Addiction biology 2009;14(2):130-43.
2009: Koob George F
New dimensions in human laboratory models of addiction.
Addiction biology 2009;14(1):1-8.
2009: Greenwell Thomas N; Walker Brendan M; Cottone Pietro; Zorrilla Eric P; Koob George F
The alpha1 adrenergic receptor antagonist prazosin reduces heroin self-administration in rats with extended access to heroin administration.
Pharmacology, biochemistry, and behavior 2009;91(3):295-302.
2009: Koob George F
Neurobiological substrates for the dark side of compulsivity in addiction.
Neuropharmacology 2009;56 Suppl 1():18-31.
2008: Mandyam Chitra D; Wee Sunmee; Crawford Elena F; Eisch Amelia J; Richardson Heather N; Koob George F
Varied access to intravenous methamphetamine self-administration differentially alters adult hippocampal neurogenesis.
Biological psychiatry 2008;64(11):958-65.
2008: Papaleo Francesco; Ghozland Sandy; Ingallinesi Manuela; Roberts Amanda J; Koob George F; Contarino Angelo
Disruption of the CRF(2) receptor pathway decreases the somatic expression of opiate withdrawal.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2008;33(12):2878-87.
2008: Richardson Heather N; Lee Soon Y; O'Dell Laura E; Koob George F; Rivier Catherine L
Alcohol self-administration acutely stimulates the hypothalamic-pituitary-adrenal axis, but alcohol dependence leads to a dampened neuroendocrine state.
The European journal of neuroscience 2008;28(8):1641-53.
2008: Koob George F; Le Moal Michel
Review. Neurobiological mechanisms for opponent motivational processes in addiction.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2008;363(1507):3113-23.
2008: Du Xin; Schwander Martin; Moresco Eva Marie Y; Viviani Pia; Haller Claudia; Hildebrand Michael S; Pak Kwang; Tarantino Lisa; Roberts Amanda; Richardson Heather; Koob George; Najmabadi Hossein; Ryan Allen F; Smith Richard J H; Müller Ulrich; Beutler Bruce
A catechol-O-methyltransferase that is essential for auditory function in mice and humans.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(38):14609-14.
2008: Gilpin Nicholas W; Richardson Heather N; Koob George F
Effects of CRF1-receptor and opioid-receptor antagonists on dependence-induced increases in alcohol drinking by alcohol-preferring (P) rats.
Alcoholism, clinical and experimental research 2008;32(9):1535-42.
2008: Gilpin Nicholas W; Misra Kaushik; Koob George F
Neuropeptide Y in the central nucleus of the amygdala suppresses dependence-induced increases in alcohol drinking.
Pharmacology, biochemistry, and behavior 2008;90(3):475-80.
2008: Gilpin N W; Richardson H N; Lumeng L; Koob G F
Dependence-induced alcohol drinking by alcohol-preferring (P) rats and outbred Wistar rats.
Alcoholism, clinical and experimental research 2008;32(9):1688-96.
2008: George Olivier; Mandyam Chitra D; Wee Sunmee; Koob George F
Extended access to cocaine self-administration produces long-lasting prefrontal cortex-dependent working memory impairments.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2008;33(10):2474-82.
2008: Gilpin Nicholas W; Richardson Heather N; Cole Maury; Koob George F
Vapor inhalation of alcohol in rats.
Current protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.] 2008;Chapter 9():Unit 9.29.
2008: Koob George F
A role for brain stress systems in addiction.
Neuron 2008;59(1):11-34.
2008: Walker Brendan M; Koob George F
Regarding "Dynorphin is a downstream effector of striatal BDNF regulation of ethanol intake".
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(7):2113; author reply 2113-4.
2008: Koob George F
Corticotropin-releasing factor, neuroplasticity (sensitization), and alcoholism.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(26):8809-10.
2008: Roberto Marisa; Gilpin Nicholas W; O'Dell Laura E; Cruz Maureen T; Morse Andrew C; Siggins George R; Koob George F
Cellular and behavioral interactions of gabapentin with alcohol dependence.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(22):5762-71.
2008: Krystal John H; Carter Cameron S; Geschwind Daniel; Manji Husseini K; March John S; Nestler Eric J; Zubieta Jon-Kar; Charney Dennis S; Goldman David; Gur Raquel E; Lieberman Jeffrey A; Roy-Byrne Peter; Rubinow David R; Anderson Stewart A; Barondes Samuel; Berman Karen F; Blair James; Braff David L; Brown E Sherwood; Calabrese Joseph R; Carlezon William A; Cook Edwin H; Davidson Richard J; Davis Michael; Desimone Robert; Drevets Wayne C; Duman Ronald S; Essock Susan M; Faraone Stephen V; Freedman Robert; Friston Karl J; Gelernter Joel; Geller Barbara; Gill Michael; Gould Elizabeth; Grace Anthony A; Grillon Christian; Gueorguieva Ralitza; Hariri Ahmad R; Innis Robert B; Jones Edward G; Kleinman Joel E; Koob George F; Krystal Andrew D; Leibenluft Ellen; Levinson Douglas F; Levitt Pat R; Lewis David A; Liberzon Israel; Lipska Barbara K; Marder Stephen R; Markou Athina; Mason Graeme F; McDougle Christopher J; McEwen Bruce S; McMahon Francis J; Meaney Michael J; Meltzer Herbert Y; Merikangas Kathleen R; Meyer-Lindenberg Andreas; Mirnics Károly; Monteggia Lisa M; Neumeister Alexander; O'Brien Charles P; Owen Michael J; Pine Daniel S; Rapoport Judith L; Rauch Scott L; Robbins Trevor W; Rosenbaum Jerrold F; Rosenberg David R; Ross Christopher A; Rush A John; Sackeim Harold A; Sanacora Gerard; Schatzberg Alan F; Shaham Yavin; Siever Larry J; Sunderland Trey; Tecott Laurence H; Thase Michael E; Todd Richard D; Weissman Myrna M; Yehuda Rachel; Yoshikawa Takeo; Young Elizabeth A; McCandless R
It is time to take a stand for medical research and against terrorism targeting medical scientists.
Biological psychiatry 2008;63(8):725-7.
2008: Wee Sunmee; Mandyam Chitra D; Lekic Dusan M; Koob George F
Alpha 1-noradrenergic system role in increased motivation for cocaine intake in rats with prolonged access.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2008;18(4):303-11.
2008: Walker Brendan M; Rasmussen Dennis D; Raskind Murray A; Koob George F
alpha1-noradrenergic receptor antagonism blocks dependence-induced increases in responding for ethanol.
Alcohol (Fayetteville, N.Y.) 2008;42(2):91-7.
2008: Ji Dong; Gilpin Nicholas W; Richardson Heather N; Rivier Catherine L; Koob George F
Effects of naltrexone, duloxetine, and a corticotropin-releasing factor type 1 receptor antagonist on binge-like alcohol drinking in rats.
Behavioural pharmacology 2008;19(1):1-12.
2008: Richardson Heather N; Zhao Yu; Fekete Eva M; Funk Cindy K; Wirsching Peter; Janda Kim D; Zorrilla Eric P; Koob George F
MPZP: a novel small molecule corticotropin-releasing factor type 1 receptor (CRF1) antagonist.
Pharmacology, biochemistry, and behavior 2008;88(4):497-510.
2008: Specio Sheila E; Wee Sunmee; O'Dell Laura E; Boutrel Benjamin; Zorrilla Eric P; Koob George F
CRF(1) receptor antagonists attenuate escalated cocaine self-administration in rats.
Psychopharmacology 2008;196(3):473-82.
2008: Walker Brendan M; Koob George F
Pharmacological evidence for a motivational role of kappa-opioid systems in ethanol dependence.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2008;33(3):643-52.
2008: Koob George F
Alcoholism, corticotropin-releasing factor, and molecular genetic allostasis.
Biological psychiatry 2008;63(2):137-8.
2008: Guillem Karine; Vouillac Caroline; Koob George F; Cador Martine; Stinus Luis
Monoamine oxidase inhibition dramatically prolongs the duration of nicotine withdrawal-induced place aversion.
Biological psychiatry 2008;63(2):158-63.
2008: Koob George F; Le Moal Michel
Addiction and the brain antireward system.
Annual review of psychology 2008;59():29-53.
2007: Caine S Barak; Thomsen Morgane; Gabriel Kara I; Berkowitz Jill S; Gold Lisa H; Koob George F; Tonegawa Susumu; Zhang Jianhua; Xu Ming
Lack of self-administration of cocaine in dopamine D1 receptor knock-out mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(48):13140-50.
2007: Zhang Zhongqi; Morse Andrew C; Koob George F; Schulteis Gery
Dose- and time-dependent expression of anxiety-like behavior in the elevated plus-maze during withdrawal from acute and repeated intermittent ethanol intoxication in rats.
Alcoholism, clinical and experimental research 2007;31(11):1811-9.
2007: Tabarin A; Diz-Chaves Y; Consoli D; Monsaingeon M; Bale T L; Culler M D; Datta R; Drago F; Vale W W; Koob G F; Zorrilla E P; Contarino A
Role of the corticotropin-releasing factor receptor type 2 in the control of food intake in mice: a meal pattern analysis.
The European journal of neuroscience 2007;26(8):2303-14.
2007: Mandyam Chitra D; Wee Sunmee; Eisch Amelia J; Richardson Heather N; Koob George F
Methamphetamine self-administration and voluntary exercise have opposing effects on medial prefrontal cortex gliogenesis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(42):11442-50.
2007: George Olivier; Ghozland Sandy; Azar Marc R; Cottone Pietro; Zorrilla Eric P; Parsons Loren H; O'Dell Laura E; Richardson Heather N; Koob George F
CRF-CRF1 system activation mediates withdrawal-induced increases in nicotine self-administration in nicotine-dependent rats.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(43):17198-203.
2007: Wee Sunmee; Wang Zhixia; Woolverton William L; Pulvirenti Luigi; Koob George F
Effect of aripiprazole, a partial dopamine D2 receptor agonist, on increased rate of methamphetamine self-administration in rats with prolonged session duration.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2007;32(10):2238-47.
2007: Koob George; Kreek Mary Jeanne
Stress, dysregulation of drug reward pathways, and the transition to drug dependence.
The American journal of psychiatry 2007;164(8):1149-59.
2007: Heilig Markus; Koob George F
A key role for corticotropin-releasing factor in alcohol dependence.
Trends in neurosciences 2007;30(8):399-406.
2007: Treweek Jennifer; Wee Sunmee; Koob George F; Dickerson Tobin J; Janda Kim D
Self-vaccination by methamphetamine glycation products chemically links chronic drug abuse and cardiovascular disease.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(28):11580-4.
2007: Funk Cindy K; Koob George F
A CRF(2) agonist administered into the central nucleus of the amygdala decreases ethanol self-administration in ethanol-dependent rats.
Brain research 2007;1155():172-8.
2007: Thorsell Annika; Repunte-Canonigo Vez; O'Dell Laura E; Chen Scott A; King Alvin R; Lekic Dusan; Koob George F; Sanna Pietro Paolo
Viral vector-induced amygdala NPY overexpression reverses increased alcohol intake caused by repeated deprivations in Wistar rats.
Brain : a journal of neurology 2007;130(Pt 5):1330-7.
2007: Le Moal Michel; Koob George F
Drug addiction: pathways to the disease and pathophysiological perspectives.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2007;17(6-7):377-93.
2007: Fekete Eva M; Inoue Koki; Zhao Yu; Rivier Jean E; Vale Wylie W; Szücs Attila; Koob George F; Zorrilla Eric P
Delayed satiety-like actions and altered feeding microstructure by a selective type 2 corticotropin-releasing factor agonist in rats: intra-hypothalamic urocortin 3 administration reduces food intake by prolonging the post-meal interval.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2007;32(5):1052-68.
2007: Chu Kathleen; Koob George F; Cole Maury; Zorrilla Eric P; Roberts Amanda J
Dependence-induced increases in ethanol self-administration in mice are blocked by the CRF1 receptor antagonist antalarmin and by CRF1 receptor knockout.
Pharmacology, biochemistry, and behavior 2007;86(4):813-21.
2007: Brogan Andrew P; Eubanks Lisa M; Koob George F; Dickerson Tobin J; Janda Kim D
Antibody-catalyzed oxidation of delta(9)-tetrahydrocannabinol.
Journal of the American Chemical Society 2007;129(12):3698-702.
2007: Wee Sunmee; Specio Sheila E; Koob George F
Effects of dose and session duration on cocaine self-administration in rats.
The Journal of pharmacology and experimental therapeutics 2007;320(3):1134-43.
2007: O'Dell Laura E; Koob George F
'Nicotine deprivation effect' in rats with intermittent 23-hour access to intravenous nicotine self-administration.
Pharmacology, biochemistry, and behavior 2007;86(2):346-53.
2007: Walker Brendan M; Koob George F
The gamma-aminobutyric acid-B receptor agonist baclofen attenuates responding for ethanol in ethanol-dependent rats.
Alcoholism, clinical and experimental research 2007;31(1):11-8.
2007: Solbrig Marylou V; Adrian Russell; Wechsler Steven L; Koob George F
Activators of potassium M currents have anticonvulsant actions in two rat models of encephalitis.
European journal of pharmacology 2007;555(1):23-9.
2007: O'Dell Laura E; Chen Scott A; Smith Ron T; Specio Sheila E; Balster Robert L; Paterson Neil E; Markou Athina; Zorrilla Eric P; Koob George F
Extended access to nicotine self-administration leads to dependence: Circadian measures, withdrawal measures, and extinction behavior in rats.
The Journal of pharmacology and experimental therapeutics 2007;320(1):180-93.
2007: Funk Cindy K; Zorrilla Eric P; Lee Mei-Jing; Rice Kenner C; Koob George F
Corticotropin-releasing factor 1 antagonists selectively reduce ethanol self-administration in ethanol-dependent rats.
Biological psychiatry 2007;61(1):78-86.
2006: Guillem Karine; Vouillac Caroline; Azar Marc R; Parsons Loren H; Koob George F; Cador Martine; Stinus Luis
Monoamine oxidase A rather than monoamine oxidase B inhibition increases nicotine reinforcement in rats.
The European journal of neuroscience 2006;24(12):3532-40.
2006: Sabino Valentina; Cottone Pietro; Koob George F; Steardo Luca; Lee Mei J; Rice Kenner C; Zorrilla Eric P
Dissociation between opioid and CRF1 antagonist sensitive drinking in Sardinian alcohol-preferring rats.
Psychopharmacology 2006;189(2):175-86.
2006: Chen Scott A; O'Dell Laura E; Hoefer Michael E; Greenwell Thomas N; Zorrilla Eric P; Koob George F
Unlimited access to heroin self-administration: independent motivational markers of opiate dependence.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2006;31(12):2692-707.
2006: O'Brien Charles P; Koob George F; Mee-Lee David; Rosenthal Richard N
New developments in addiction treatment.
The Journal of clinical psychiatry 2006;67(11):1801-12.
2006: Eubanks Lisa M; Rogers Claude J; Beuscher Albert E; Koob George F; Olson Arthur J; Dickerson Tobin J; Janda Kim D
A molecular link between the active component of marijuana and Alzheimer's disease pathology.
Molecular pharmaceutics 2006;3(6):773-7.
2006: Funk Cindy K; O'Dell Laura E; Crawford Elena F; Koob George F
Corticotropin-releasing factor within the central nucleus of the amygdala mediates enhanced ethanol self-administration in withdrawn, ethanol-dependent rats.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(44):11324-32.
2006: Steffensen Scott C; Stobbs Sarah H; Colago Eric E O; Lee Rong-Sheng; Koob George F; Gallegos Roger A; Henriksen Steven J
Contingent and non-contingent effects of heroin on mu-opioid receptor-containing ventral tegmental area GABA neurons.
Experimental neurology 2006;202(1):139-51.
2006: Crabbe John C; Phillips Tamara J; Harris R Adron; Arends Michael A; Koob George F
Alcohol-related genes: contributions from studies with genetically engineered mice.
Addiction biology 2006;11(3-4):195-269.
2006: Koob George F
The neurobiology of addiction: a neuroadaptational view relevant for diagnosis.
Addiction (Abingdon, England) 2006;101 Suppl 1():23-30.
2006: O'Dell Laura E; Bruijnzeel Adie W; Smith Ron T; Parsons Loren H; Merves Michele L; Goldberger Bruce A; Richardson Heather N; Koob George F; Markou Athina
Diminished nicotine withdrawal in adolescent rats: implications for vulnerability to addiction.
Psychopharmacology 2006;186(4):612-9.
2006: Kenny Paul J; Chen Scott A; Kitamura Osamu; Markou Athina; Koob George F
Conditioned withdrawal drives heroin consumption and decreases reward sensitivity.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(22):5894-900.
2006: Kitamura Osamu; Wee Sunmee; Specio Sheila E; Koob George F; Pulvirenti Luigi
Escalation of methamphetamine self-administration in rats: a dose-effect function.
Psychopharmacology 2006;186(1):48-53.
2006: Mulligan Megan K; Ponomarev Igor; Hitzemann Robert J; Belknap John K; Tabakoff Boris; Harris R Adron; Crabbe John C; Blednov Yuri A; Grahame Nicholas J; Phillips Tamara J; Finn Deborah A; Hoffman Paula L; Iyer Vishwanath R; Koob George F; Bergeson Susan E
Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(16):6368-73.
2006: Hoefer Michael E; Voskanian Steven J; Koob George F; Pulvirenti Luigi
Effects of terguride, ropinirole, and acetyl-L-carnitine on methamphetamine withdrawal in the rat.
Pharmacology, biochemistry, and behavior 2006;83(3):403-9.
2006: Johnson Bankole A; Koob George F; Schuckit Marc A; Mason Barbara J; Ait-Daoud Nassima
Understanding and treating alcohol dependence.
Alcoholism, clinical and experimental research 2006;30(3):567-84.
2006: Solbrig Marylou V; Adrian Russell; Baratta Janie; Lauterborn Julie C; Koob George F
Kappa opioid control of seizures produced by a virus in an animal model.
Brain : a journal of neurology 2006;129(Pt 3):642-54.
2006: Heinrichs Stephen C; Koob George F
Application of experimental stressors in laboratory rodents.
Current protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.] 2006;Chapter 8():Unit8.4.
2006: Kranzler Henry R; Koob George; Gastfriend David R; Swift Robert M; Willenbring Mark L
Advances in the pharmacotherapy of alcoholism: challenging misconceptions.
Alcoholism, clinical and experimental research 2006;30(2):272-81.
2006: Koob George F
A role for GABA in alcohol dependence.
Advances in pharmacology (San Diego, Calif.) 2006;54():205-29.
2005: Boutrel Benjamin; Kenny Paul J; Specio Sheila E; Martin-Fardon Rémi; Markou Athina; Koob George F; de Lecea Luis
Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(52):19168-73.
2005: Tabarin Antoine; Diz-Chaves Y; Carmona Maria del Carmen; Catargi Bogdan; Zorrilla Eric P; Roberts Amanda J; Coscina Donald V; Rousset Sophie; Redonnet Anabelle; Parker Graham C; Inoue Koki; Ricquier Daniel; Pénicaud Luc; Kieffer Brigitte L; Koob Georges F
Resistance to diet-induced obesity in mu-opioid receptor-deficient mice: evidence for a "thrifty gene".
Diabetes 2005;54(12):3510-6.
2005: Qi Longwu; Yamamoto Noboru; Meijler Michael M; Altobell Laurence J; Koob George F; Wirsching Peter; Janda Kim D
Delta9-tetrahydrocannabinol immunochemical studies: haptens, monoclonal antibodies, and a convenient synthesis of radiolabeled delta9-tetrahydrocannabinol.
Journal of medicinal chemistry 2005;48(23):7389-99.
2005: Koob George F; Le Moal Michel
Plasticity of reward neurocircuitry and the 'dark side' of drug addiction.
Nature neuroscience 2005;8(11):1442-4.
2005: Guillem Karine; Vouillac Caroline; Azar Marc R; Parsons Loren H; Koob George F; Cador Martine; Stinus Luis
Monoamine oxidase inhibition dramatically increases the motivation to self-administer nicotine in rats.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(38):8593-600.
2005: Sanchis-Segura Carles; Grisel Judy E; Olive M Foster; Ghozland Sandra; Koob George F; Roberts Amanda J; Cowen Michael S
Role of the endogenous opioid system on the neuropsychopharmacological effects of ethanol: new insights about an old question.
Alcoholism, clinical and experimental research 2005;29(8):1522-7.
2005: Ahmed Serge H; Lutjens Robert; van der Stap Lena D; Lekic Dusan; Romano-Spica Vincenzo; Morales Marisela; Koob George F; Repunte-Canonigo Vez; Sanna Pietro Paolo
Gene expression evidence for remodeling of lateral hypothalamic circuitry in cocaine addiction.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(32):11533-8.
2005: Izzo Emanuela; Sanna Pietro Paolo; Koob George F
Impairment of dopaminergic system function after chronic treatment with corticotropin-releasing factor.
Pharmacology, biochemistry, and behavior 2005;81(4):701-8.
2005: O'Dell L E; Purdy R H; Covey D F; Richardson H N; Roberto M; Koob G F
Epipregnanolone and a novel synthetic neuroactive steroid reduce alcohol self-administration in rats.
Pharmacology, biochemistry, and behavior 2005;81(3):543-50.
2005: Ahmed Serge H; Koob George F
Transition to drug addiction: a negative reinforcement model based on an allostatic decrease in reward function.
Psychopharmacology 2005;180(3):473-90.
2005: Zorrilla Eric P; Inoue Koki; Fekete Eva M; Tabarin Antoine; Valdez Glenn R; Koob George F
Measuring meals: structure of prandial food and water intake of rats.
American journal of physiology. Regulatory, integrative and comparative physiology 2005;288(6):R1450-67.
2005: Kenny Paul J; Boutrel Benjamin; Gasparini Fabrizio; Koob George F; Markou Athina
Metabotropic glutamate 5 receptor blockade may attenuate cocaine self-administration by decreasing brain reward function in rats.
Psychopharmacology 2005;179(1):247-54.
2005: Breese George R; Chu Kathleen; Dayas Christopher V; Funk Douglas; Knapp Darin J; Koob George F; Lê Dzung Anh; O'Dell Laura E; Overstreet David H; Roberts Amanda J; Sinha Rajita; Valdez Glenn R; Weiss Friedbert
Stress enhancement of craving during sobriety: a risk for relapse.
Alcoholism, clinical and experimental research 2005;29(2):185-95.
2005: Zorrilla Eric P; Inoue Koki; Valdez Glenn R; Tabarin Antoine; Koob George F
Leptin and post-prandial satiety: acute central leptin more potently reduces meal frequency than meal size in the rat.
Psychopharmacology 2005;177(3):324-35.
2005: Stinus Luis; Cador Martine; Zorrilla Eric P; Koob George F
Buprenorphine and a CRF1 antagonist block the acquisition of opiate withdrawal-induced conditioned place aversion in rats.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2005;30(1):90-8.
2005: De Witte Philippe; Littleton John; Parot Philippe; Koob George
Neuroprotective and abstinence-promoting effects of acamprosate: elucidating the mechanism of action.
CNS drugs 2005;19(6):517-37.
2004: Valdez Glenn R; Koob George F
Allostasis and dysregulation of corticotropin-releasing factor and neuropeptide Y systems: implications for the development of alcoholism.
Pharmacology, biochemistry, and behavior 2004;79(4):671-89.
2004: O'Dell Laura E; Roberts Amanda J; Smith Ron T; Koob George F
Enhanced alcohol self-administration after intermittent versus continuous alcohol vapor exposure.
Alcoholism, clinical and experimental research 2004;28(11):1676-82.
2004: Heinrichs Stephen C; Koob George F
Corticotropin-releasing factor in brain: a role in activation, arousal, and affect regulation.
The Journal of pharmacology and experimental therapeutics 2004;311(2):427-40.
2004: Navarro Miguel; Carrera M Rocio A; Del Arco Ignacio; Trigo Jose Manuel; Koob George F; Rodríguez de Fonseca Fernando
Cannabinoid receptor antagonist reduces heroin self-administration only in dependent rats.
European journal of pharmacology 2004;501(1-3):235-7.
2004: Koob George F
A role for GABA mechanisms in the motivational effects of alcohol.
Biochemical pharmacology 2004;68(8):1515-25.
2004: Martin Gilles; Guadaño-Ferraz Ana; Morte Beatriz; Ahmed Serge; Koob George F; De Lecea Luis; Siggins George R
Chronic morphine treatment alters N-methyl-D-aspartate receptors in freshly isolated neurons from nucleus accumbens.
The Journal of pharmacology and experimental therapeutics 2004;311(1):265-73.
2004: Boutrel Benjamin; Koob George F
What keeps us awake: the neuropharmacology of stimulants and wakefulness-promoting medications.
Sleep 2004;27(6):1181-94.
2004: Zorrilla Eric P; Reinhardt Lindsay E; Valdez Glenn R; Inoue Koki; Rivier Jean E; Vale Wylie W; Koob George F
Human urocortin 2, a corticotropin-releasing factor (CRF)2 agonist, and ovine CRF, a CRF1 agonist, differentially alter feeding and motor activity.
The Journal of pharmacology and experimental therapeutics 2004;310(3):1027-34.
2004: Koob George F; Greenwell Thomas N
Neuropeptide S: a novel activating anxiolytic?
Neuron 2004;43(4):441-2.
2004: Carrera M Rocio A; Kaufmann Gunnar F; Mee Jenny M; Meijler Michael M; Koob George F; Janda Kim D
Treating cocaine addiction with viruses.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(28):10416-21.
2004: Zorrilla Eric P; Koob George F
The therapeutic potential of CRF1 antagonists for anxiety.
Expert opinion on investigational drugs 2004;13(7):799-828.
2004: O'Dell Laura E; Bruijnzeel Adrie W; Ghozland Sandy; Markou Athina; Koob George F
Nicotine withdrawal in adolescent and adult rats.
Annals of the New York Academy of Sciences 2004;1021():167-74.
2004: Valdez Glenn R; Sabino Valentina; Koob George F
Increased anxiety-like behavior and ethanol self-administration in dependent rats: reversal via corticotropin-releasing factor-2 receptor activation.
Alcoholism, clinical and experimental research 2004;28(6):865-72.
2004: Inoue Koki; Zorrilla Eric P; Tabarin Antoine; Valdez Glenn R; Iwasaki Sinichi; Kiriike Nobuo; Koob George F
Reduction of anxiety after restricted feeding in the rat: implication for eating disorders.
Biological psychiatry 2004;55(11):1075-81.
2004: Azar M R; Ahmed S H; Lintz R; Gutierrez T; Stinus L; Koob G F
A non-invasive gating device for continuous drug delivery that allows control over the timing and duration of spontaneous opiate withdrawal.
Journal of neuroscience methods 2004;135(1-2):129-35.
2004: Sanna Pietro Paolo; Koob George F
Cocaine's long run.
Nature medicine 2004;10(4):340-1.
2004: Ahmed Serge H; Koob George F
Changes in response to a dopamine receptor antagonist in rats with escalating cocaine intake.
Psychopharmacology 2004;172(4):450-4.
2004: Solbrig Marylou V; Koob George F
Epilepsy, CNS viral injury and dynorphin.
Trends in pharmacological sciences 2004;25(2):98-104.
2004: Carrera M Rocío A; Ashley Jon A; Hoffman Timothy Z; Isomura Shigeki; Wirsching Peter; Koob George F; Janda Kim D
Investigations using immunization to attenuate the psychoactive effects of nicotine.
Bioorganic & medicinal chemistry 2004;12(3):563-70.
2004: Koob George F; Ahmed Serge H; Boutrel Benjamin; Chen Scott A; Kenny Paul J; Markou Athina; O'Dell Laura E; Parsons Loren H; Sanna Pietro Paolo
Neurobiological mechanisms in the transition from drug use to drug dependence.
Neuroscience and biobehavioral reviews 2004;27(8):739-49.
2004: Weed Michael R; Gold Lisa H; Polis Ilham; Koob George F; Fox Howard S; Taffe Michael A
Impaired performance on a rhesus monkey neuropsychological testing battery following simian immunodeficiency virus infection.
AIDS research and human retroviruses 2004;20(1):77-89.
2004: O'Dell Laura E; Alomary Ahmed A; Vallée Monique; Koob George F; Fitzgerald Robert L; Purdy Robert H
Ethanol-induced increases in neuroactive steroids in the rat brain and plasma are absent in adrenalectomized and gonadectomized rats.
European journal of pharmacology 2004;484(2-3):241-7.
2004: Ben-Shahar Osnat; Ahmed Serge H; Koob George F; Ettenberg Aaron
The transition from controlled to compulsive drug use is associated with a loss of sensitization.
Brain research 2004;995(1):46-54.
2004: Koob George F
Allostatic view of motivation: implications for psychopathology.
Nebraska Symposium on Motivation. Nebraska Symposium on Motivation 2004;50():1-18.
2003: Koob George F
Neuroadaptive mechanisms of addiction: studies on the extended amygdala.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2003;13(6):442-52.
2003: Kenny P J; Paterson N E; Boutrel B; Semenova S; Harrison A A; Gasparini F; Koob G F; Skoubis P D; Markou A
Metabotropic glutamate 5 receptor antagonist MPEP decreased nicotine and cocaine self-administration but not nicotine and cocaine-induced facilitation of brain reward function in rats.
Annals of the New York Academy of Sciences 2003;1003():415-8.
2003: Kenny Paul J; Koob George F; Markou Athina
Conditioned facilitation of brain reward function after repeated cocaine administration.
Behavioral neuroscience 2003;117(5):1103-7.
2003: Zorrilla Eric P; Taché Yvette; Koob George F
Nibbling at CRF receptor control of feeding and gastrocolonic motility.
Trends in pharmacological sciences 2003;24(8):421-7.
2003: Valdez Glenn R; Zorrilla Eric P; Rivier Jean; Vale Wylie W; Koob George F
Locomotor suppressive and anxiolytic-like effects of urocortin 3, a highly selective type 2 corticotropin-releasing factor agonist.
Brain research 2003;980(2):206-12.
2003: Heyser Charles J; Moc Kelly; Koob George F
Effects of naltrexone alone and in combination with acamprosate on the alcohol deprivation effect in rats.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2003;28(8):1463-71.
2003: Ahmed Serge H; Lin Daniel; Koob George F; Parsons Loren H
Escalation of cocaine self-administration does not depend on altered cocaine-induced nucleus accumbens dopamine levels.
Journal of neurochemistry 2003;86(1):102-13.
2003: Vallée Monique; Purdy Robert H; Mayo Willy; Koob George F; Le Moal Michel
Neuroactive steroids: new biomarkers of cognitive aging.
The Journal of steroid biochemistry and molecular biology 2003;85(2-5):329-35.
2003: Walker John R; Chen Scott A; Moffitt Heather; Inturrisi Charles E; Koob George F
Chronic opioid exposure produces increased heroin self-administration in rats.
Pharmacology, biochemistry, and behavior 2003;75(2):349-54.
2003: Inoue Koki; Valdez Glenn R; Reyes Teresa M; Reinhardt Lindsay E; Tabarin Antoine; Rivier Jean; Vale Wylie W; Sawchenko Paul E; Koob George F; Zorrilla Eric P
Human urocortin II, a selective agonist for the type 2 corticotropin-releasing factor receptor, decreases feeding and drinking in the rat.
The Journal of pharmacology and experimental therapeutics 2003;305(1):385-93.
2003: Solbrig Marylou V; Koob George F
Neuropharmacological sequelae of persistent CNS viral infections: lessons from Borna disease virus.
Pharmacology, biochemistry, and behavior 2003;74(4):777-87.
2003: Valdez Glenn R; Zorrilla Eric P; Roberts Amanda J; Koob George F
Antagonism of corticotropin-releasing factor attenuates the enhanced responsiveness to stress observed during protracted ethanol abstinence.
Alcohol (Fayetteville, N.Y.) 2003;29(2):55-60.
2003: Koob George F
Alcoholism: allostasis and beyond.
Alcoholism, clinical and experimental research 2003;27(2):232-43.
2003: Caillé Stéphanie; Stinus Luis; Espejo Emilio F; De Deurwaerdère Philippe; Spampinato Umberto; Koob George F
Inhibition of 5-HT neurotransmission increases clonidine protective effects on naloxone-induced conditioned place aversion in morphine-dependent rats.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2003;28(2):276-83.
2003: Alomary Ahmed A; Vallée Monique; O'Dell Laura E; Koob George F; Purdy Robert H; Fitzgerald Robert L
Acutely administered ethanol participates in testosterone synthesis and increases testosterone in rat brain.
Alcoholism, clinical and experimental research 2003;27(1):38-43.
2003: Kenny Paul J; Polis Ilham; Koob George F; Markou Athina
Low dose cocaine self-administration transiently increases but high dose cocaine persistently decreases brain reward function in rats.
The European journal of neuroscience 2003;17(1):191-5.
2003: Koob George F; Roberts Amanda J; Kieffer Brigitte L; Heyser Charles J; Katner Simon N; Ciccocioppo Roberto; Weiss Friedbert
Animal models of motivation for drinking in rodents with a focus on opioid receptor neuropharmacology.
Recent developments in alcoholism : an official publication of the American Medical Society on Alcoholism, the Research Society on Alcoholism, and the National Council on Alcoholism 2003;16():263-81.
2002: Izzo Emanuela; Martin-Fardon Rémi; Koob George F; Weiss Friedbert; Sanna Pietro Paolo
Neural plasticity and addiction: PI3-kinase and cocaine behavioral sensitization.
Nature neuroscience 2002;5(12):1263-4.
2002: Solbrig Marylou V; Koob George F; Lipkin W Ian
Key role for enkephalinergic tone in cortico-striatal-thalamic function.
The European journal of neuroscience 2002;16(9):1819-22.
2002: Valdez Glenn R; Roberts Amanda J; Chan Karen; Davis Heather; Brennan Molly; Zorrilla Eric P; Koob George F
Increased ethanol self-administration and anxiety-like behavior during acute ethanol withdrawal and protracted abstinence: regulation by corticotropin-releasing factor.
Alcoholism, clinical and experimental research 2002;26(10):1494-501.
2002: Zorrilla Eric P; Schulteis Gery; Ormsby Amanda; Klaassen Alwin; Ling Nicholas; McCarthy James R; Koob George F; De Souza Errol B
Urocortin shares the memory modulating effects of corticotropin-releasing factor (CRF): mediation by CRF1 receptors.
Brain research 2002;952(2):200-10.
2002: Zorrilla Eric P; Valdez Glenn R; Nozulak Joachim; Koob George F; Markou Athina
Effects of antalarmin, a CRF type 1 receptor antagonist, on anxiety-like behavior and motor activation in the rat.
Brain research 2002;952(2):188-99.
2002: Sanna Pietro Paolo; Simpson Cindy; Lutjens Robert; Koob George
ERK regulation in chronic ethanol exposure and withdrawal.
Brain research 2002;948(1-2):186-91.
2002: Walker John R; Terenius Lars; Koob George F
Conditioned opioid withdrawal decreases nociceptin/orphanin FQ levels in the frontal cortex and olfactory tubercle.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2002;27(2):203-11.
2002: Vetter Douglas E; Li Chien; Zhao Lingyun; Contarino Angelo; Liberman M Charles; Smith George W; Marchuk Yelena; Koob George F; Heinemann Stephen F; Vale Wylie; Lee Kuo-Fen
Urocortin-deficient mice show hearing impairment and increased anxiety-like behavior.
Nature genetics 2002;31(4):363-9.
2002: Valdez Glenn R; Inoue Koki; Koob George F; Rivier Jean; Vale Wylie; Zorrilla Eric P
Human urocortin II: mild locomotor suppressive and delayed anxiolytic-like effects of a novel corticotropin-releasing factor related peptide.
Brain research 2002;943(1):142-50.
2002: Caillé Stéphanie; Espejo Emilio F; Koob George F; Stinus Luis
Dorsal and median raphe serotonergic system lesion does not alter the opiate withdrawal syndrome.
Pharmacology, biochemistry, and behavior 2002;72(4):979-86.
2002: Ahmed Serge H; Kenny Paul J; Koob George F; Markou Athina
Neurobiological evidence for hedonic allostasis associated with escalating cocaine use.
Nature neuroscience 2002;5(7):625-6.
2002: Contarino Angelo; Picetti Roberto; Matthes Hans W; Koob George F; Kieffer Brigitte L; Gold Lisa H
Lack of reward and locomotor stimulation induced by heroin in mu-opioid receptor-deficient mice.
European journal of pharmacology 2002;446(1-3):103-9.
2002: Smith A D; Amalric M; Koob G F; Zigmond M J
Effect of bilateral 6-hydroxydopamine lesions of the medial forebrain bundle on reaction time.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2002;26(6):756-64.
2002: Ryabinin Andrey E; Bachtell Ryan K; Heinrichs Stephen C; Lee Soon; Rivier Catherine; Olive M Foster; Mehmert Kristin K; Camarini Rosana; Kim Joseph A; Koenig Heather N; Nannini Michelle A; Hodge Clyde W; Roberts Amanda J; Koob George F
The corticotropin-releasing factor/urocortin system and alcohol.
Alcoholism, clinical and experimental research 2002;26(5):714-22.
2002: Koob George F; Mason Barbara J; De Witte Philippe; Littleton John; Siggins George R
Potential neuroprotective effects of acamprosate.
Alcoholism, clinical and experimental research 2002;26(4):586-92.
2002: Hungund Basalingappa L; Basavarajappa Balapal S; Vadasz Csaba; Kunos George; Rodriguez de Fonseca Fernando; Colombo Giancarlo; Serra Salvatore; Parsons Loren; Koob George F
Ethanol, endocannabinoids, and the cannabinoidergic signaling system.
Alcoholism, clinical and experimental research 2002;26(4):565-74.
2002: Pulvirenti Luigi; Koob George F
Being partial to psychostimulant addiction therapy.
Trends in pharmacological sciences 2002;23(4):151-3.
2002: Spina M G; Merlo-Pich E; Akwa Y; Balducci C; Basso A M; Zorrilla E P; Britton K T; Rivier J; Vale W W; Koob G F
Time-dependent induction of anxiogenic-like effects after central infusion of urocortin or corticotropin-releasing factor in the rat.
Psychopharmacology 2002;160(2):113-21.
2002: Orsini Cristina; Izzo Emanuela; Koob George F; Pulvirenti Luigi
Blockade of nitric oxide synthesis reduces responding for cocaine self-administration during extinction and reinstatement.
Brain research 2002;925(2):133-40.
2002: Bale Tracy L; Picetti Roberto; Contarino Angelo; Koob George F; Vale Wylie W; Lee Kuo-Fen
Mice deficient for both corticotropin-releasing factor receptor 1 (CRFR1) and CRFR2 have an impaired stress response and display sexually dichotomous anxiety-like behavior.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(1):193-9.
2001: Vallée M; Shen W; Heinrichs S C; Zorumski C F; Covey D F; Koob G F; Purdy R H
Steroid structure and pharmacological properties determine the anti-amnesic effects of pregnenolone sulphate in the passive avoidance task in rats.
The European journal of neuroscience 2001;14(12):2003-10.
2001: Orsini C; Koob G F; Pulvirenti L
Dopamine partial agonist reverses amphetamine withdrawal in rats.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2001;25(5):789-92.
2001: Currie P J; Coscina D V; Bishop C; Coiro C D; Koob G F; Rivier J; Vale W
Hypothalamic paraventricular nucleus injections of urocortin alter food intake and respiratory quotient.
Brain research 2001;916(1-2):222-8.
2001: Roberts A J; Gold L H; Polis I; McDonald J S; Filliol D; Kieffer B L; Koob G F
Increased ethanol self-administration in delta-opioid receptor knockout mice.
Alcoholism, clinical and experimental research 2001;25(9):1249-56.
2001: Navarro M; Carrera M R; Fratta W; Valverde O; Cossu G; Fattore L; Chowen J A; Gomez R; del Arco I; Villanua M A; Maldonado R; Koob G F; Rodriguez de Fonseca F
Functional interaction between opioid and cannabinoid receptors in drug self-administration.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(14):5344-50.
2001: Lê A D; Kiianmaa K; Cunningham C L; Engel J A; Ericson M; Söderpalm B; Koob G F; Roberts A J; Weiss F; Hyytiä P; Janhunen S; Mikkola J; Bäckström P; Ponomarev I; Crabbe J C
Neurobiological processes in alcohol addiction.
Alcoholism, clinical and experimental research 2001;25(5 Suppl ISBRA):144S-151S.
2001: Zorrilla E P; Schulteis G; Ling N; Koob G F; De Souza E B
Performance-enhancing effects of CRF-BP ligand inhibitors.
Neuroreport 2001;12(6):1231-4.
2001: Izzo E; Orsini C; Koob G F; Pulvirenti L
A dopamine partial agonist and antagonist block amphetamine self-administration in a progressive ratio schedule.
Pharmacology, biochemistry, and behavior 2001;68(4):701-8.
2001: Macey D J; Froestl W; Koob G F; Markou A
Both GABA(B) receptor agonist and antagonists decreased brain stimulation reward in the rat.
Neuropharmacology 2001;40(5):676-85.
2001: David V; Gold L H; Koob G F; Cazala P
Anxiogenic-like effects limit rewarding effects of cocaine in balb/cbyj mice.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2001;24(3):300-18.
2001: Carrera M R; Ashley J A; Wirsching P; Koob G F; Janda K D
A second-generation vaccine protects against the psychoactive effects of cocaine.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(4):1988-92.
2001: Gracy K N; Dankiewicz L A; Koob G F
Opiate withdrawal-induced fos immunoreactivity in the rat extended amygdala parallels the development of conditioned place aversion.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2001;24(2):152-60.
2001: Koob G F; Le Moal M
Drug addiction, dysregulation of reward, and allostasis.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2001;24(2):97-129.
2001: Weiss F; Koob G F
Drug addiction: functional neurotoxicity of the brain reward systems.
Neurotoxicity research 2001;3(1):145-56.
2001: Vallée M; Mayo W; Koob G F; Le Moal M
Neurosteroids in learning and memory processes.
International review of neurobiology 2001;46():273-320.
2000: Richter R M; Zorrilla E P; Basso A M; Koob G F; Weiss F
Altered amygdalar CRF release and increased anxiety-like behavior in Sardinian alcohol-preferring rats: a microdialysis and behavioral study.
Alcoholism, clinical and experimental research 2000;24(12):1765-72.
2000: Vallée M; Rivera J D; Koob G F; Purdy R H; Fitzgerald R L
Quantification of neurosteroids in rat plasma and brain following swim stress and allopregnanolone administration using negative chemical ionization gas chromatography/mass spectrometry.
Analytical biochemistry 2000;287(1):153-66.
2000: Solbrig M V; Koob G F; Parsons L H; Kadota T; Horscroft N; Briese T; Lipkin W I
Neurotrophic factor expression after CNS viral injury produces enhanced sensitivity to psychostimulants: potential mechanism for addiction vulnerability.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(21):RC104.
2000: Koob G
Drug addiction.
Neurobiology of disease 2000;7(5):543-5.
2000: Morse A C; Schulteis G; Holloway F A; Koob G F
Conditioned place aversion to the "hangover" phase of acute ethanol administration in the rat.
Alcohol (Fayetteville, N.Y.) 2000;22(1):19-24.
2000: Koob G F
Animal models of craving for ethanol.
Addiction (Abingdon, England) 2000;95 Suppl 2():S73-81.
2000: Contarino A; Dellu F; Koob G F; Smith G W; Lee K F; Vale W W; Gold L H
Dissociation of locomotor activation and suppression of food intake induced by CRF in CRFR1-deficient mice.
Endocrinology 2000;141(7):2698-702.
2000: Schulteis G; Ahmed S H; Morse A C; Koob G F; Everitt B J
Conditioning and opiate withdrawal.
Nature 2000;405(6790):1013-4.
2000: Roberts A J; McDonald J S; Heyser C J; Kieffer B L; Matthes H W; Koob G F; Gold L H
mu-Opioid receptor knockout mice do not self-administer alcohol.
The Journal of pharmacology and experimental therapeutics 2000;293(3):1002-8.
2000: Macey D J; Koob G F; Markou A
CRF and urocortin decreased brain stimulation reward in the rat: reversal by a CRF receptor antagonist.
Brain research 2000;866(1-2):82-91.
2000: Roberts A J; Heyser C J; Cole M; Griffin P; Koob G F
Excessive ethanol drinking following a history of dependence: animal model of allostasis.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2000;22(6):581-94.
2000: Carrera M R; Ashley J A; Zhou B; Wirsching P; Koob G F; Janda K D
Cocaine vaccines: antibody protection against relapse in a rat model.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(11):6202-6.
2000: Stinus L; Caille S; Koob G F
Opiate withdrawal-induced place aversion lasts for up to 16 weeks.
Psychopharmacology 2000;149(2):115-20.
2000: Bale T L; Contarino A; Smith G W; Chan R; Gold L H; Sawchenko P E; Koob G F; Vale W W; Lee K F
Mice deficient for corticotropin-releasing hormone receptor-2 display anxiety-like behaviour and are hypersensitive to stress.
Nature genetics 2000;24(4):410-4.
2000: Ahmed S H; Walker J R; Koob G F
Persistent increase in the motivation to take heroin in rats with a history of drug escalation.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2000;22(4):413-21.
2000: Smith A D; Smith D L; Zigmond M J; Amalric M; Koob G F
Differential effects of dopamine receptor subtype blockade on performance of rats in a reaction-time paradigm.
Psychopharmacology 2000;148(4):355-60.
2000: Spina M G; Basso A M; Zorrilla E P; Heyser C J; Rivier J; Vale W; Merlo-Pich E; Koob G F
Behavioral effects of central administration of the novel CRF antagonist astressin in rats.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2000;22(3):230-9.
2000: Watkins S S; Stinus L; Koob G F; Markou A
Reward and somatic changes during precipitated nicotine withdrawal in rats: centrally and peripherally mediated effects.
The Journal of pharmacology and experimental therapeutics 2000;292(3):1053-64.
2000: Gracy K N; Dankiewicz L A; Weiss F; Koob G F
Heroin-specific stimuli reinstate operant heroin-seeking behavior in rats after prolonged extinction.
Pharmacology, biochemistry, and behavior 2000;65(3):489-94.
2000: Lin D; Koob G F; Markou A
Time-dependent alterations in ICSS thresholds associated with repeated amphetamine administrations.
Pharmacology, biochemistry, and behavior 2000;65(3):407-17.
2000: Watkins S S; Koob G F; Markou A
Neural mechanisms underlying nicotine addiction: acute positive reinforcement and withdrawal.
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 2000;2(1):19-37.
2000: Walker J R; Ahmed S H; Gracy K N; Koob G F
Microinjections of an opiate receptor antagonist into the bed nucleus of the stria terminalis suppress heroin self-administration in dependent rats.
Brain research 2000;854(1-2):85-92.
2000: Britton K T; Akwa Y; Spina M G; Koob G F
Neuropeptide Y blocks anxiogenic-like behavioral action of corticotropin-releasing factor in an operant conflict test and elevated plus maze.
Peptides 2000;21(1):37-44.
2000: Dellu F; Contarino A; Simon H; Koob G F; Gold L H
Genetic differences in response to novelty and spatial memory using a two-trial recognition task in mice.
Neurobiology of learning and memory 2000;73(1):31-48.
2000: Koob G F
Neurobiology of addiction. Toward the development of new therapies.
Annals of the New York Academy of Sciences 2000;909():170-85.
1999: Rodríguez de Fonseca F; Roberts A J; Bilbao A; Koob G F; Navarro M
Cannabinoid receptor antagonist SR141716A decreases operant ethanol self administration in rats exposed to ethanol-vapor chambers.
Zhongguo yao li xue bao = Acta pharmacologica Sinica 1999;20(12):1109-14.
1999: Akwa Y; Purdy R H; Koob G F; Britton K T
The amygdala mediates the anxiolytic-like effect of the neurosteroid allopregnanolone in rat.
Behavioural brain research 1999;106(1-2):119-25.
1999: Baldo B A; Koob G F; Markou A
Role of adenosine A2 receptors in brain stimulation reward under baseline conditions and during cocaine withdrawal in rats.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(24):11017-26.
1999: Koob G F
Cocaine reward and dopamine receptors: love at first site.
Archives of general psychiatry 1999;56(12):1107-8.
1999: Koob G F; Heinrichs S C
A role for corticotropin releasing factor and urocortin in behavioral responses to stressors.
Brain research 1999;848(1-2):141-52.
1999: Koob G F
Corticotropin-releasing factor, norepinephrine, and stress.
Biological psychiatry 1999;46(9):1167-80.
1999: Walker J R; King M; Izzo E; Koob G F; Pasternak G W
Antagonism of heroin and morphine self-administration in rats by the morphine-6beta-glucuronide antagonist 3-O-methylnaltrexone.
European journal of pharmacology 1999;383(2):115-9.
1999: Weed M R; Taffe M A; Polis I; Roberts A C; Robbins T W; Koob G F; Bloom F E; Gold L H
Performance norms for a rhesus monkey neuropsychological testing battery: acquisition and long-term performance.
Brain research. Cognitive brain research 1999;8(3):185-201.
1999: Ahmed S H; Koob G F
Long-lasting increase in the set point for cocaine self-administration after escalation in rats.
Psychopharmacology 1999;146(3):303-12.
1999: Martin G; Ahmed S H; Blank T; Spiess J; Koob G F; Siggins G R
Chronic morphine treatment alters NMDA receptor-mediated synaptic transmission in the nucleus accumbens.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(20):9081-9.
1999: Heyser C J; Roberts A J; Schulteis G; Koob G F
Central administration of an opiate antagonist decreases oral ethanol self-administration in rats.
Alcoholism, clinical and experimental research 1999;23(9):1468-76.
1999: Koob G F; Caine S B
Cocaine addiction therapy--are we partially there?
Nature medicine 1999;5(9):993-5.
1999: Lin D; Koob G F; Markou A
Differential effects of withdrawal from chronic amphetamine or fluoxetine administration on brain stimulation reward in the rat--interactions between the two drugs.
Psychopharmacology 1999;145(3):283-94.
1999: Caillé S; Espejo E F; Reneric J P; Cador M; Koob G F; Stinus L
Total neurochemical lesion of noradrenergic neurons of the locus ceruleus does not alter either naloxone-precipitated or spontaneous opiate withdrawal nor does it influence ability of clonidine to reverse opiate withdrawal.
The Journal of pharmacology and experimental therapeutics 1999;290(2):881-92.
1999: Solbrig M; Koob G; Lipkin W
Orofacial dyskinesias and dystonia in rats infected with Borna disease virus; a model for tardive dyskinetic syndromes.
Molecular psychiatry 1999;4(4):310-2.
1999: Contarino A; Dellu F; Koob G F; Smith G W; Lee K F; Vale W; Gold L H
Reduced anxiety-like and cognitive performance in mice lacking the corticotropin-releasing factor receptor 1.
Brain research 1999;835(1):1-9.
1999: Basso A M; Spina M; Rivier J; Vale W; Koob G F
Corticotropin-releasing factor antagonist attenuates the "anxiogenic-like" effect in the defensive burying paradigm but not in the elevated plus-maze following chronic cocaine in rats.
Psychopharmacology 1999;145(1):21-30.
1999: Roberts A J; Heyser C J; Koob G F
Operant self-administration of sweetened versus unsweetened ethanol: effects on blood alcohol levels.
Alcoholism, clinical and experimental research 1999;23(7):1151-7.
1999: Lee R S; Criado J R; Koob G F; Henriksen S J
Cellular responses of nucleus accumbens neurons to opiate-seeking behavior: I. Sustained responding during heroin self-administration.
Synapse (New York, N.Y.) 1999;33(1):49-58.
1999: Koob G F
The role of the striatopallidal and extended amygdala systems in drug addiction.
Annals of the New York Academy of Sciences 1999;877():445-60.
1999: Criado J R; Li H; Jiang X; Spina M; Huitrón-Reséndiz S; Liapakis G; Calbet M; Siehler S; Henriksen S J; Koob G; Hoyer D; Sutcliffe J G; Goodman M; de Lecea L
Structural and compositional determinants of cortistatin activity.
Journal of neuroscience research 1999;56(6):611-9.
1999: Schulteis G; Heyser C J; Koob G F
Differential expression of response-disruptive and somatic indices of opiate withdrawal during the initiation and development of opiate dependence.
Behavioural pharmacology 1999;10(3):235-42.
1999: Carrera M R; Schulteis G; Koob G F
Heroin self-administration in dependent Wistar rats: increased sensitivity to naloxone.
Psychopharmacology 1999;144(2):111-20.
1999: Parsons L H; Koob G F; Weiss F
RU 24969, a 5-HT1B/1A receptor agonist, potentiates cocaine-induced increases in nucleus accumbens dopamine.
Synapse (New York, N.Y.) 1999;32(2):132-5.
1999: Watkins S S; Epping-Jordan M P; Koob G F; Markou A
Blockade of nicotine self-administration with nicotinic antagonists in rats.
Pharmacology, biochemistry, and behavior 1999;62(4):743-51.
1999: Baldo B A; Jain K; Veraldi L; Koob G F; Markou A
A dopamine D1 agonist elevates self-stimulation thresholds: comparison to other dopamine-selective drugs.
Pharmacology, biochemistry, and behavior 1999;62(4):659-72.
1999: Leshner A I; Koob G F
Drugs of abuse and the brain.
Proceedings of the Association of American Physicians 1999;111(2):99-108.
1999: Harrison A A; Parsons L H; Koob G F; Markou A
RU 24969, a 5-HT1A/1B agonist, elevates brain stimulation reward thresholds: an effect reversed by GR 127935, a 5-HT1B/1D antagonist.
Psychopharmacology 1999;141(3):242-50.
1999: Baldo B A; Markou A; Koob G F
Increased sensitivity to the locomotor depressant effect of a dopamine receptor antagonist during cocaine withdrawal in the rat.
Psychopharmacology 1999;141(2):135-44.
1999: Koob G F; Weiss F; Tiffany S T; Zieglgansberger W; Spanagel R
Animal models of craving: a roundtable discussion.
Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism 1999;23(3):233-6.
1999: Koob G F
Stress, corticotropin-releasing factor, and drug addiction.
Annals of the New York Academy of Sciences 1999;897():27-45.
1998: Kosten T R; Markou A; Koob G F
Depression and stimulant dependence: neurobiology and pharmacotherapy.
The Journal of nervous and mental disease 1998;186(12):737-45.
1998: Kimes A S; Maldonado R; Ambrosio E; Koob G F; London E D
Cerebral glucose metabolism during opioid withdrawal following methylnaloxonium injection into the locus coeruleus.
Brain research 1998;814(1-2):1-12.
1998: Parsons L H; Weiss F; Koob G F
Serotonin1B receptor stimulation enhances cocaine reinforcement.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(23):10078-89.
1998: Schulteis G; Stinus L; Risbrough V B; Koob G F
Clonidine blocks acquisition but not expression of conditioned opiate withdrawal in rats.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1998;19(5):406-16.
1998: Navarro M; Chowen J; Rocío A Carrera M; del Arco I; Villanúa M A; Martin Y; Roberts A J; Koob G F; de Fonseca F R
CB1 cannabinoid receptor antagonist-induced opiate withdrawal in morphine-dependent rats.
Neuroreport 1998;9(15):3397-402.
1998: Roberts A J; Smith A D; Weiss F; Rivier C; Koob G F
Estrous cycle effects on operant responding for ethanol in female rats.
Alcoholism, clinical and experimental research 1998;22(7):1564-9.
1998: Ahmed S H; Koob G F
Transition from moderate to excessive drug intake: change in hedonic set point.
Science (New York, N.Y.) 1998;282(5387):298-300.
1998: Koob G F; Sanna P P; Bloom F E
Neuroscience of addiction.
Neuron 1998;21(3):467-76.
1998: Pulvirenti L; Balducci C; Piercy M; Koob G F
Characterization of the effects of the partial dopamine agonist terguride on cocaine self-administration in the rat.
The Journal of pharmacology and experimental therapeutics 1998;286(3):1231-8.
1998: Eckardt M J; File S E; Gessa G L; Grant K A; Guerri C; Hoffman P L; Kalant H; Koob G F; Li T K; Tabakoff B
Effects of moderate alcohol consumption on the central nervous system.
Alcoholism, clinical and experimental research 1998;22(5):998-1040.
1998: Walker J R; Spina M; Terenius L; Koob G F
Nociceptin fails to affect heroin self-administration in the rat.
Neuroreport 1998;9(10):2243-7.
1998: Schulteis G; Yackey M; Risbrough V; Koob G F
Anxiogenic-like effects of spontaneous and naloxone-precipitated opiate withdrawal in the elevated plus-maze.
Pharmacology, biochemistry, and behavior 1998;60(3):727-31.
1998: Lee R S; Koob G F; Henriksen S J
Electrophysiological responses of nucleus accumbens neurons to novelty stimuli and exploratory behavior in the awake, unrestrained rat.
Brain research 1998;799(2):317-22.
1998: Kreek M J; Koob G F
Drug dependence: stress and dysregulation of brain reward pathways.
Drug and alcohol dependence 1998;51(1-2):23-47.
1998: Smith G W; Aubry J M; Dellu F; Contarino A; Bilezikjian L M; Gold L H; Chen R; Marchuk Y; Hauser C; Bentley C A; Sawchenko P E; Koob G F; Vale W; Lee K F
Corticotropin releasing factor receptor 1-deficient mice display decreased anxiety, impaired stress response, and aberrant neuroendocrine development.
Neuron 1998;20(6):1093-102.
1998: Raber J; Sorg O; Horn T F; Yu N; Koob G F; Campbell I L; Bloom F E
Inflammatory cytokines: putative regulators of neuronal and neuro-endocrine function.
Brain research. Brain research reviews 1998;26(2-3):320-6.
1998: Roberts A J; McArthur R A; Hull E E; Post C; Koob G F
Effects of amperozide, 8-OH-DPAT, and FG 5974 on operant responding for ethanol.
Psychopharmacology 1998;137(1):25-32.
1998: Epping-Jordan M P; Watkins S S; Koob G F; Markou A
Dramatic decreases in brain reward function during nicotine withdrawal.
Nature 1998;393(6680):76-9.
1998: Solbrig M V; Koob G F; Lipkin W I
Cocaine sensitivity in Borna disease virus-infected rats.
Pharmacology, biochemistry, and behavior 1998;59(4):1047-52.
1998: Britton K T; Koob G F
Neuropharmacology. Premenstrual steroids?
Nature 1998;392(6679):869-70.
1998: Heinrichs S C; Klaassen A; Koob G F; Schulteis G; Ahmed S; De Souza E B
Corticotropin-releasing factor receptor blockade enhances conditioned aversive properties of cocaine in rats.
Psychopharmacology 1998;136(3):247-55.
1998: Markou A; Kosten T R; Koob G F
Neurobiological similarities in depression and drug dependence: a self-medication hypothesis.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1998;18(3):135-74.
1998: Epping-Jordan M P; Markou A; Koob G F
The dopamine D-1 receptor antagonist SCH 23390 injected into the dorsolateral bed nucleus of the stria terminalis decreased cocaine reinforcement in the rat.
Brain research 1998;784(1-2):105-15.
1998: Koob G F; Roberts A J; Schulteis G; Parsons L H; Heyser C J; Hyytiä P; Merlo-Pich E; Weiss F
Neurocircuitry targets in ethanol reward and dependence.
Alcoholism, clinical and experimental research 1998;22(1):3-9.
1998: Heyser C J; Schulteis G; Durbin P; Koob G F
Chronic acamprosate eliminates the alcohol deprivation effect while having limited effects on baseline responding for ethanol in rats.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1998;18(2):125-33.
1998: Koob G F; Rocio M; Carrera A; Gold L H; Heyser C J; Maldonado-Irizarry C; Markou A; Parsons L H; Roberts A J; Schulteis G; Stinus L; Walker J R; Weissenborn R; Weiss F
Substance dependence as a compulsive behavior.
Journal of psychopharmacology (Oxford, England) 1998;12(1):39-48.
1998: Heinrichs S C; Menzaghi F; Koob G F
Neuropeptide Y-induced feeding and its control.
Vitamins and hormones 1998;54():51-66.
1998: Koob G F
Circuits, drugs, and drug addiction.
Advances in pharmacology (San Diego, Calif.) 1998;42():978-82.
1998: Koob G F
Drug abuse and alcoholism. Overview.
Advances in pharmacology (San Diego, Calif.) 1998;42():969-77.
1997: Walker J R; Koob G F
Orphan anxiety.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(26):14217-9.
1997: Koob G F; Le Moal M
Drug abuse: hedonic homeostatic dysregulation.
Science (New York, N.Y.) 1997;278(5335):52-8.
1997: Ahmed S H; Koob G F
Cocaine- but not food-seeking behavior is reinstated by stress after extinction.
Psychopharmacology 1997;132(3):289-95.
1997: Brot M D; Rall G F; Oldstone M B; Koob G F; Gold L H
Deficits in discriminated learning remain despite clearance of long-term persistent viral infection in mice.
Journal of neurovirology 1997;3(4):265-73.
1997: Heyser C J; Schulteis G; Koob G F
Increased ethanol self-administration after a period of imposed ethanol deprivation in rats trained in a limited access paradigm.
Alcoholism, clinical and experimental research 1997;21(5):784-91.
1997: Britton K T; Southerland S; Van Uden E; Kirby D; Rivier J; Koob G
Anxiolytic activity of NPY receptor agonists in the conflict test.
Psychopharmacology 1997;132(1):6-13.
1997: Heyser C J; McDonald J S; Beauchamp V; Koob G F; Gold L H
The effects of cocaine on operant responding for food in several strains of mice.
Psychopharmacology 1997;132(2):202-8.
1997: Caine S B; Koob G F; Parsons L H; Everitt B J; Schwartz J C; Sokoloff P
D3 receptor test in vitro predicts decreased cocaine self-administration in rats.
Neuroreport 1997;8(9-10):2373-7.
1997: Koob G F; Caine S B; Parsons L; Markou A; Weiss F
Opponent process model and psychostimulant addiction.
Pharmacology, biochemistry, and behavior 1997;57(3):513-21.
1997: Deroche V; Caine S B; Heyser C J; Polis I; Koob G F; Gold L H
Differences in the liability to self-administer intravenous cocaine between C57BL/6 x SJL and BALB/cByJ mice.
Pharmacology, biochemistry, and behavior 1997;57(3):429-40.
1997: Rodríguez de Fonseca F; Carrera M R; Navarro M; Koob G F; Weiss F
Activation of corticotropin-releasing factor in the limbic system during cannabinoid withdrawal.
Science (New York, N.Y.) 1997;276(5321):2050-4.
1997: Brot M D; Akwa Y; Purdy R H; Koob G F; Britton K T
The anxiolytic-like effects of the neurosteroid allopregnanolone: interactions with GABA(A) receptors.
European journal of pharmacology 1997;325(1):1-7.
1997: Raber J; Koob G F; Bloom F E
Interferon-alpha and transforming growth factor-beta 1 regulate corticotropin-releasing factor release from the amygdala: comparison with the hypothalamic response.
Neurochemistry international 1997;30(4-5):455-63.
1997: Pulvirenti L; Balducci C; Koob G F
Dextromethorphan reduces intravenous cocaine self-administration in the rat.
European journal of pharmacology 1997;321(3):279-83.
1997: Schulteis G; Heyser C J; Koob G F
Opiate withdrawal signs precipitated by naloxone following a single exposure to morphine: potentiation with a second morphine exposure.
Psychopharmacology 1997;129(1):56-65.
1997: Roberts A J; Koob G F
The neurobiology of addiction: an overview.
Alcohol health and research world 1997;21(2):101-6.
1997: Koob G F; Nestler E J
The neurobiology of drug addiction.
The Journal of neuropsychiatry and clinical neurosciences 1997;9(3):482-97.
1996: Parsons L H; Weiss F; Koob G F
Serotonin1b receptor stimulation enhances dopamine-mediated reinforcement.
Psychopharmacology 1996;128(2):150-60.
1996: Schulteis G; Koob G F
Reinforcement processes in opiate addiction: a homeostatic model.
Neurochemical research 1996;21(11):1437-54.
1996: Prospéro-García O; Gold L H; Fox H S; Polis I; Koob G F; Bloom F E; Henriksen S J
Microglia-passaged simian immunodeficiency virus induces neurophysiological abnormalities in monkeys.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(24):14158-63.
1996: Roberts A J; Cole M; Koob G F
Intra-amygdala muscimol decreases operant ethanol self-administration in dependent rats.
Alcoholism, clinical and experimental research 1996;20(7):1289-98.
1996: Solbrig M V; Koob G F; Fallon J H; Reid S; Lipkin W I
Prefrontal cortex dysfunction in Borna disease virus (BDV)--infected rats.
Biological psychiatry 1996;40(7):629-36.
1996: Heinrichs S C; Stenzel-Poore M P; Gold L H; Battenberg E; Bloom F E; Koob G F; Vale W W; Pich E M
Learning impairment in transgenic mice with central overexpression of corticotropin-releasing factor.
Neuroscience 1996;74(2):303-11.
1996: Vankova M E; Weinger M B; Chen D Y; Bronson J B; Motis V; Koob G F
Role of central mu, delta-1, and kappa-1 opioid receptors in opioid-induced muscle rigidity in the rat.
Anesthesiology 1996;85(3):574-83.
1996: Parsons L H; Caine S B; Sokoloff P; Schwartz J C; Koob G F; Weiss F
Neurochemical evidence that postsynaptic nucleus accumbens D3 receptor stimulation enhances cocaine reinforcement.
Journal of neurochemistry 1996;67(3):1078-89.
1996: Spina M; Merlo-Pich E; Chan R K; Basso A M; Rivier J; Vale W; Koob G F
Appetite-suppressing effects of urocortin, a CRF-related neuropeptide.
Science (New York, N.Y.) 1996;273(5281):1561-4.
1996: Weissenborn R; Deroche V; Koob G F; Weiss F
Effects of dopamine agonists and antagonists on cocaine-induced operant responding for a cocaine-associated stimulus.
Psychopharmacology 1996;126(4):311-22.
1996: Menzaghi F; Heinrichs S C; Vargas-Cortes M; Goldstein G; Koob G F
IRI-514, a synthetic peptide analogue of thymopentin, reduces the behavioral response to social stress in rats.
Physiology & behavior 1996;60(2):397-401.
1996: Solbrig M V; Koob G F; Joyce J N; Lipkin W I
A neural substrate of hyperactivity in borna disease: changes in brain dopamine receptors.
Virology 1996;222(2):332-8.
1996: Koob G F
Hedonic valence, dopamine and motivation.
Molecular psychiatry 1996;1(3):186-9.
1996: Hyytiä P; Schulteis G; Koob G F
Intravenous heroin and ethanol self-administration by alcohol-preferring AA and alcohol-avoiding ANA rats.
Psychopharmacology 1996;125(3):248-54.
1996: Matthews K; Baldo B A; Markou A; Lown O; Overstreet D H; Koob G F
Rewarding electrical brain stimulation: similar thresholds for Flinders Sensitive Line Hypercholinergic and Flinders Resistant Line Hypocholinergic rats.
Physiology & behavior 1996;59(6):1155-62.
1996: de la Torre J C; Mallory M; Brot M; Gold L; Koob G; Oldstone M B; Masliah E
Viral persistence in neurons alters synaptic plasticity and cognitive functions without destruction of brain cells.
Virology 1996;220(2):508-15.
1996: Korte S M; Korte-Bouws G A; Koob G F; De Kloet E R; Bohus B
Mineralocorticoid and glucocorticoid receptor antagonists in animal models of anxiety.
Pharmacology, biochemistry, and behavior 1996;54(1):261-7.
1996: Koob G F
Drug addiction: the yin and yang of hedonic homeostasis.
Neuron 1996;16(5):893-6.
1996: Weiss F; Parsons L H; Schulteis G; Hyytiä P; Lorang M T; Bloom F E; Koob G F
Ethanol self-administration restores withdrawal-associated deficiencies in accumbal dopamine and 5-hydroxytryptamine release in dependent rats.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1996;16(10):3474-85.
1996: Solbrig M V; Koob G F; Lipkin W I
Naloxone-induced seizures in rats infected with Borna disease virus.
Neurology 1996;46(4):1170-1.
1996: Macey D J; Schulteis G; Heinrichs S C; Koob G F
Time-dependent quantifiable withdrawal from ethanol in the rat: effect of method of dependence induction.
Alcohol (Fayetteville, N.Y.) 1996;13(2):163-70.
1996: Bono G; Balducci C; Richelmi P; Koob G F; Pulvirenti L
Dopamine partial receptor agonists reduce ethanol intake in the rat.
European journal of pharmacology 1996;296(3):233-8.
1996: Schulteis G; Hyytiä P; Heinrichs S C; Koob G F
Effects of chronic ethanol exposure on oral self-administration of ethanol or saccharin by Wistar rats.
Alcoholism, clinical and experimental research 1996;20(1):164-71.
1996: Glassman A H; Koob G F
Neuropharmacology. Psychoactive smoke.
Nature 1996;379(6567):677-8.
1996: Rodríguez de Fonseca F; Rubio P; Menzaghi F; Merlo-Pich E; Rivier J; Koob G F; Navarro M
Corticotropin-releasing factor (CRF) antagonist [D-Phe12,Nle21,38,C alpha MeLeu37]CRF attenuates the acute actions of the highly potent cannabinoid receptor agonist HU-210 on defensive-withdrawal behavior in rats.
The Journal of pharmacology and experimental therapeutics 1996;276(1):56-64.
1996: Pulvirenti L; Balducci C; Koob G F
Inhibition of nitric oxide synthesis reduces intravenous cocaine self-administration in the rat.
Neuropharmacology 1996;35(12):1811-4.
1996: Parsons L H; Koob G F; Weiss F
Extracellular serotonin is decreased in the nucleus accumbens during withdrawal from cocaine self-administration.
Behavioural brain research 1996;73(1-2):225-8.
1995: Heinrichs S C; Menzaghi F; Merlo Pich E; Britton K T; Koob G F
The role of CRF in behavioral aspects of stress.
Annals of the New York Academy of Sciences 1995;771():92-104.
1995: Carrera M R; Ashley J A; Parsons L H; Wirsching P; Koob G F; Janda K D
Suppression of psychoactive effects of cocaine by active immunization.
Nature 1995;378(6558):727-30.
1995: Caine S B; Heinrichs S C; Coffin V L; Koob G F
Effects of the dopamine D-1 antagonist SCH 23390 microinjected into the accumbens, amygdala or striatum on cocaine self-administration in the rat.
Brain research 1995;692(1-2):47-56.
1995: Parsons L H; Koob G F; Weiss F
Serotonin dysfunction in the nucleus accumbens of rats during withdrawal after unlimited access to intravenous cocaine.
The Journal of pharmacology and experimental therapeutics 1995;274(3):1182-91.
1995: Hyytiä P; Koob G F
GABAA receptor antagonism in the extended amygdala decreases ethanol self-administration in rats.
European journal of pharmacology 1995;283(1-3):151-9.
1995: Merlo Pich E; Lorang M; Yeganeh M; Rodriguez de Fonseca F; Raber J; Koob G F; Weiss F
Increase of extracellular corticotropin-releasing factor-like immunoreactivity levels in the amygdala of awake rats during restraint stress and ethanol withdrawal as measured by microdialysis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1995;15(8):5439-47.
1995: Schulteis G; Markou A; Cole M; Koob G F
Decreased brain reward produced by ethanol withdrawal.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(13):5880-4.
1995: Weissenborn R; Yackey M; Koob G F; Weiss F
Measures of cocaine-seeking behavior using a multiple schedule of food and drug self-administration in rats.
Drug and alcohol dependence 1995;38(3):237-46.
1995: Richter R M; Pich E M; Koob G F; Weiss F
Sensitization of cocaine-stimulated increase in extracellular levels of corticotropin-releasing factor from the rat amygdala after repeated administration as determined by intracranial microdialysis.
Neuroscience letters 1995;187(3):169-72.
1995: Raber J; Koob G F; Bloom F E
Interleukin-2 (IL-2) induces corticotropin-releasing factor (CRF) release from the amygdala and involves a nitric oxide-mediated signaling; comparison with the hypothalamic response.
The Journal of pharmacology and experimental therapeutics 1995;272(2):815-24.
1995: Rodríguez De Fonseca F; Rubio P; Martín-Calderón J L; Caine S B; Koob G F; Navarro M
The dopamine receptor agonist 7-OH-DPAT modulates the acquisition and expression of morphine-induced place preference.
European journal of pharmacology 1995;274(1-3):47-55.
1995: Withers N W; Pulvirenti L; Koob G F; Gillin J C
Cocaine abuse and dependence.
Journal of clinical psychopharmacology 1995;15(1):63-78.
1995: Weinger M B; Chen D Y; Lin T; Lau C; Koob G F; Smith N T
A role for CNS alpha-2 adrenergic receptors in opiate-induced muscle rigidity in the rat.
Brain research 1995;669(1):10-8.
1995: Brot M D; Koob G F; Britton K T
Anxiolytic effects of steroid hormones during the estrous cycle. Interactions with ethanol.
Recent developments in alcoholism : an official publication of the American Medical Society on Alcoholism, the Research Society on Alcoholism, and the National Council on Alcoholism 1995;12():243-59.
1994: Solbrig M V; Koob G F; Fallon J H; Lipkin W I
Tardive dyskinetic syndrome in rats infected with Borna disease virus.
Neurobiology of disease 1994;1(3):111-9.
1994: Schulteis G; Markou A; Gold L H; Stinus L; Koob G F
Relative sensitivity to naloxone of multiple indices of opiate withdrawal: a quantitative dose-response analysis.
The Journal of pharmacology and experimental therapeutics 1994;271(3):1391-8.
1994: Xu M; Moratalla R; Gold L H; Hiroi N; Koob G F; Graybiel A M; Tonegawa S
Dopamine D1 receptor mutant mice are deficient in striatal expression of dynorphin and in dopamine-mediated behavioral responses.
Cell 1994;79(4):729-42.
1994: Pulvirenti L; Berrier R; Kreifeldt M; Koob G F
Modulation of locomotor activity by NMDA receptors in the nucleus accumbens core and shell regions of the rat.
Brain research 1994;664(1-2):231-6.
1994: Markou A; Matthews K; Overstreet D H; Koob G F; Geyer M A
Flinders resistant hypocholinergic rats exhibit startle sensitization and reduced startle thresholds.
Biological psychiatry 1994;36(10):680-8.
1994: Heinrichs S C; Menzaghi F; Pich E M; Baldwin H A; Rassnick S; Britton K T; Koob G F
Anti-stress action of a corticotropin-releasing factor antagonist on behavioral reactivity to stressors of varying type and intensity.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1994;11(3):179-86.
1994: Menzaghi F; Rassnick S; Heinrichs S; Baldwin H; Pich E M; Weiss F; Koob G F
The role of corticotropin-releasing factor in the anxiogenic effects of ethanol withdrawal.
Annals of the New York Academy of Sciences 1994;739():176-84.
1994: Pulvirenti L; Koob G F
Dopamine receptor agonists, partial agonists and psychostimulant addiction.
Trends in pharmacological sciences 1994;15(10):374-9.
1994: Schulteis G; Koob G
Neuropharmacology. Dark side of drug dependence.
Nature 1994;371(6493):108-9.
1994: Gold L H; Brot M D; Polis I; Schroeder R; Tishon A; de la Torre J C; Oldstone M B; Koob G F
Behavioral effects of persistent lymphocytic choriomeningitis virus infection in mice.
Behavioral and neural biology 1994;62(2):100-9.
1994: Korte S M; Korte-Bouws G A; Bohus B; Koob G F
Effect of corticotropin-releasing factor antagonist on behavioral and neuroendocrine responses during exposure to defensive burying paradigm in rats.
Physiology & behavior 1994;56(1):115-20.
1994: Caine S B; Koob G F
Effects of dopamine D-1 and D-2 antagonists on cocaine self-administration under different schedules of reinforcement in the rat.
The Journal of pharmacology and experimental therapeutics 1994;270(1):209-18.
1994: Gillin J C; Pulvirenti L; Withers N; Golshan S; Koob G
The effects of lisuride on mood and sleep during acute withdrawal in stimulant abusers: a preliminary report.
Biological psychiatry 1994;35(11):843-9.
1994: Mitler M M; Aldrich M S; Koob G F; Zarcone V P
Narcolepsy and its treatment with stimulants. ASDA standards of practice.
Sleep 1994;17(4):352-71.
1994: Menzaghi F; Howard R L; Heinrichs S C; Vale W; Rivier J; Koob G F
Characterization of a novel and potent corticotropin-releasing factor antagonist in rats.
The Journal of pharmacology and experimental therapeutics 1994;269(2):564-72.
1994: Stenzel-Poore M P; Heinrichs S C; Rivest S; Koob G F; Vale W W
Overproduction of corticotropin-releasing factor in transgenic mice: a genetic model of anxiogenic behavior.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1994;14(5 Pt 1):2579-84.
1994: Pulvirenti L; Koob G F
Lisuride reduces intravenous cocaine self-administration in rats.
Pharmacology, biochemistry, and behavior 1994;47(4):819-22.
1994: Cole B J; Koob G F
Corticotropin-releasing factor and schedule-induced polydipsia.
Pharmacology, biochemistry, and behavior 1994;47(3):393-8.
1994: Caine S B; Koob G F
Effects of mesolimbic dopamine depletion on responding maintained by cocaine and food.
Journal of the experimental analysis of behavior 1994;61(2):213-21.
1994: Raber J; Pich E M; Koob G F; Bloom F E
IL-1 beta potentiates the acetylcholine-induced release of vasopressin from the hypothalamus in vitro, but not from the amygdala.
Neuroendocrinology 1994;59(3):208-17.
1994: Menzaghi F; Heinrichs S C; Merlo-Pich E; Tilders F J; Koob G F
Involvement of hypothalamic corticotropin-releasing factor neurons in behavioral responses to novelty in rats.
Neuroscience letters 1994;168(1-2):139-42.
1994: Gold L H; Stinus L; Inturrisi C E; Koob G F
Prolonged tolerance, dependence and abstinence following subcutaneous morphine pellet implantation in the rat.
European journal of pharmacology 1994;253(1-2):45-51.
1994: Heilig M; Koob G F; Ekman R; Britton K T
Corticotropin-releasing factor and neuropeptide Y: role in emotional integration.
Trends in neurosciences 1994;17(2):80-5.
1994: Pulvirenti L; Smith D; Koob G F
SDZ 208-911, an amino-ergoline with partial dopamine agonist properties, dose dependently increases cocaine self-administration in the rat.
Psychopharmacology 1994;113(3-4):518-20.
1994: Koob G F; Caine B; Markou A; Pulvirenti L; Weiss F
Role for the mesocortical dopamine system in the motivating effects of cocaine.
NIDA research monograph 1994;145():1-18.
1994: Koob G F; Rassnick S; Heinrichs S; Weiss F
Alcohol, the reward system and dependence.
EXS 1994;71():103-14.
1993: Menzaghi F; Heinrichs S C; Pich E M; Weiss F; Koob G F
The role of limbic and hypothalamic corticotropin-releasing factor in behavioral responses to stress.
Annals of the New York Academy of Sciences 1993;697():142-54.
1993: Weiss F; Lorang M T; Bloom F E; Koob G F
Oral alcohol self-administration stimulates dopamine release in the rat nucleus accumbens: genetic and motivational determinants.
The Journal of pharmacology and experimental therapeutics 1993;267(1):250-8.
1993: Robledo P; Maldonado R; Koob G F
Neurotensin injected into the nucleus accumbens blocks the psychostimulant effects of cocaine but does not attenuate cocaine self-administration in the rat.
Brain research 1993;622(1-2):105-12.
1993: Rassnick S; Stinus L; Koob G F
The effects of 6-hydroxydopamine lesions of the nucleus accumbens and the mesolimbic dopamine system on oral self-administration of ethanol in the rat.
Brain research 1993;623(1):16-24.
1993: Pich E M; Koob G F; Heilig M; Menzaghi F; Vale W; Weiss F
Corticotropin-releasing factor release from the mediobasal hypothalamus of the rat as measured by microdialysis.
Neuroscience 1993;55(3):695-707.
1993: Menzaghi F; Heinrichs S C; Pich E M; Tilders F J; Koob G F
Functional impairment of hypothalamic corticotropin-releasing factor neurons with immunotargeted toxins enhances food intake induced by neuropeptide Y.
Brain research 1993;618(1):76-82.
1993: Swerdlow N R; Koob G F; Cador M; Lorang M; Hauger R L
Pituitary-adrenal axis responses to acute amphetamine in the rat.
Pharmacology, biochemistry, and behavior 1993;45(3):629-37.
1993: Robledo P; Koob G F
Two discrete nucleus accumbens projection areas differentially mediate cocaine self-administration in the rat.
Behavioural brain research 1993;55(2):159-66.
1993: Negus S S; Henriksen S J; Mattox A; Pasternak G W; Portoghese P S; Takemori A E; Weinger M B; Koob G F
Effect of antagonists selective for mu, delta and kappa opioid receptors on the reinforcing effects of heroin in rats.
The Journal of pharmacology and experimental therapeutics 1993;265(3):1245-52.
1993: Heilig M; McLeod S; Brot M; Heinrichs S C; Menzaghi F; Koob G F; Britton K T
Anxiolytic-like action of neuropeptide Y: mediation by Y1 receptors in amygdala, and dissociation from food intake effects.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1993;8(4):357-63.
1993: Caine S B; Koob G F
Modulation of cocaine self-administration in the rat through D-3 dopamine receptors.
Science (New York, N.Y.) 1993;260(5115):1814-6.
1993: Heinrichs S C; Menzaghi F; Pich E M; Hauger R L; Koob G F
Corticotropin-releasing factor in the paraventricular nucleus modulates feeding induced by neuropeptide Y.
Brain research 1993;611(1):18-24.
1993: Maldonado R; Robledo P; Chover A J; Caine S B; Koob G F
D1 dopamine receptors in the nucleus accumbens modulate cocaine self-administration in the rat.
Pharmacology, biochemistry, and behavior 1993;45(1):239-42.
1993: Hammer R P; Pires W S; Markou A; Koob G F
Withdrawal following cocaine self-administration decreases regional cerebral metabolic rate in critical brain reward regions.
Synapse (New York, N.Y.) 1993;14(1):73-80.
1993: Pulvirenti L; Koob G F
Lisuride reduces psychomotor retardation during withdrawal from chronic intravenous amphetamine self-administration in rats.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1993;8(3):213-8.
1993: Amalric M; Berhow M; Polis I; Koob G F
Selective effects of low-dose D2 dopamine receptor antagonism in a reaction-time task in rats.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1993;8(3):195-200.
1993: Rassnick S; Krechman J; Koob G F
Chronic ethanol produces a decreased sensitivity to the response-disruptive effects of GABA receptor complex antagonists.
Pharmacology, biochemistry, and behavior 1993;44(4):943-50.
1993: Cador M; Cole B J; Koob G F; Stinus L; Le Moal M
Central administration of corticotropin releasing factor induces long-term sensitization to D-amphetamine.
Brain research 1993;606(2):181-6.
1993: Rassnick S; Heinrichs S C; Britton K T; Koob G F
Microinjection of a corticotropin-releasing factor antagonist into the central nucleus of the amygdala reverses anxiogenic-like effects of ethanol withdrawal.
Brain research 1993;605(1):25-32.
1993: Maldonado R; Koob G F
Destruction of the locus coeruleus decreases physical signs of opiate withdrawal.
Brain research 1993;605(1):128-38.
1993: Rassnick S; Pulvirenti L; Koob G F
SDZ-205,152, a novel dopamine receptor agonist, reduces oral ethanol self-administration in rats.
Alcohol (Fayetteville, N.Y.) 1993;10(2):127-32.
1993: Negus S S; Pasternak G W; Koob G F; Weinger M B
Antagonist effects of beta-funaltrexamine and naloxonazine on alfentanil-induced antinociception and muscle rigidity in the rat.
The Journal of pharmacology and experimental therapeutics 1993;264(2):739-45.
1993: Rassnick S; D'Amico E; Riley E; Koob G F
GABA antagonist and benzodiazepine partial inverse agonist reduce motivated responding for ethanol.
Alcoholism, clinical and experimental research 1993;17(1):124-30.
1993: Baldwin H A; Koob G F
Rapid induction of conditioned opiate withdrawal in the rat.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1993;8(1):15-21.
1993: Wahlestedt C; Pich E M; Koob G F; Yee F; Heilig M
Modulation of anxiety and neuropeptide Y-Y1 receptors by antisense oligodeoxynucleotides.
Science (New York, N.Y.) 1993;259(5094):528-31.
1993: Koob G F; Heinrichs S C; Pich E M; Menzaghi F; Baldwin H; Miczek K; Britton K T
The role of corticotropin-releasing factor in behavioural responses to stress.
Ciba Foundation symposium 1993;172():277-89; discussion 290-5.
1993: Pich E M; Heinrichs S C; Rivier C; Miczek K A; Fisher D A; Koob G F
Blockade of pituitary-adrenal axis activation induced by peripheral immunoneutralization of corticotropin-releasing factor does not affect the behavioral response to social defeat stress in rats.
Psychoneuroendocrinology 1993;18(7):495-507.
1993: Amalric M; Koob G F
Functionally selective neurochemical afferents and efferents of the mesocorticolimbic and nigrostriatal dopamine system.
Progress in brain research 1993;99():209-26.
1993: Markou A; Weiss F; Gold L H; Caine S B; Schulteis G; Koob G F
Animal models of drug craving.
Psychopharmacology 1993;112(2-3):163-82.
1992: Cador M; Ahmed S H; Koob G F; Le Moal M; Stinus L
Corticotropin-releasing factor induces a place aversion independent of its neuroendocrine role.
Brain research 1992;597(2):304-9.
1992: Maldonado R; Negus S; Koob G F
Precipitation of morphine withdrawal syndrome in rats by administration of mu-, delta- and kappa-selective opioid antagonists.
Neuropharmacology 1992;31(12):1231-41.
1992: Weiss F; Paulus M P; Lorang M T; Koob G F
Increases in extracellular dopamine in the nucleus accumbens by cocaine are inversely related to basal levels: effects of acute and repeated administration.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1992;12(11):4372-80.
1992: Markou A; Koob G F
Bromocriptine reverses the elevation in intracranial self-stimulation thresholds observed in a rat model of cocaine withdrawal.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1992;7(3):213-24.
1992: Weiss F; Markou A; Lorang M T; Koob G F
Basal extracellular dopamine levels in the nucleus accumbens are decreased during cocaine withdrawal after unlimited-access self-administration.
Brain research 1992;593(2):314-8.
1992: Pulvirenti L; Maldonado-Lopez R; Koob G F
NMDA receptors in the nucleus accumbens modulate intravenous cocaine but not heroin self-administration in the rat.
Brain research 1992;594(2):327-30.
1992: Heinrichs S C; Cole B J; Pich E M; Menzaghi F; Koob G F; Hauger R L
Endogenous corticotropin-releasing factor modulates feeding induced by neuropeptide Y or a tail-pinch stressor.
Peptides 1992;13(5):879-84.
1992: Heilig M; McLeod S; Koob G K; Britton K T
Anxiolytic-like effect of neuropeptide Y (NPY), but not other peptides in an operant conflict test.
Regulatory peptides 1992;41(1):61-9.
1992: Weiss F; Hurd Y L; Ungerstedt U; Markou A; Plotsky P M; Koob G F
Neurochemical correlates of cocaine and ethanol self-administration.
Annals of the New York Academy of Sciences 1992;654():220-41.
1992: Koob G F
Neural mechanisms of drug reinforcement.
Annals of the New York Academy of Sciences 1992;654():171-91.
1992: Robledo P; Maldonado-Lopez R; Koob G F
Role of dopamine receptors in the nucleus accumbens in the rewarding properties of cocaine.
Annals of the New York Academy of Sciences 1992;654():509-12.
1992: Rassnick S; D'Amico E; Riley E; Pulvirenti L; Zieglgänsberger W; Koob G F
GABA and nucleus accumbens glutamate neurotransmission modulate ethanol self-administration in rats.
Annals of the New York Academy of Sciences 1992;654():502-5.
1992: Cador M; Dumas S; Cole B J; Mallet J; Koob G F; Le Moal M; Stinus L
Behavioral sensitization induced by psychostimulants or stress: search for a molecular basis and evidence for a CRF-dependent phenomenon.
Annals of the New York Academy of Sciences 1992;654():416-20.
1992: Koob G F
Drugs of abuse: anatomy, pharmacology and function of reward pathways.
Trends in pharmacological sciences 1992;13(5):177-84.
1992: Maldonado R; Stinus L; Gold L H; Koob G F
Role of different brain structures in the expression of the physical morphine withdrawal syndrome.
The Journal of pharmacology and experimental therapeutics 1992;261(2):669-77.
1992: Koob G F; Maldonado R; Stinus L
Neural substrates of opiate withdrawal.
Trends in neurosciences 1992;15(5):186-91.
1992: Heinrichs S C; Pich E M; Miczek K A; Britton K T; Koob G F
Corticotropin-releasing factor antagonist reduces emotionality in socially defeated rats via direct neurotropic action.
Brain research 1992;581(2):190-7.
1992: Weinberger S B; Koob G F; Martinez J L
Differences in one-way active avoidance learning in mice of three inbred strains.
Behavior genetics 1992;22(2):177-88.
1992: Britton K T; McLeod S; Koob G F; Hauger R
Pregnane steroid alphaxalone attenuates anxiogenic behavioral effects of corticotropin releasing factor and stress.
Pharmacology, biochemistry, and behavior 1992;41(2):399-403.
1992: Markou A; Koob G F
Construct validity of a self-stimulation threshold paradigm: effects of reward and performance manipulations.
Physiology & behavior 1992;51(1):111-9.
1992: Rassnick S; Koob G F; Geyer M A
Responding to acoustic startle during chronic ethanol intoxication and withdrawal.
Psychopharmacology 1992;106(3):351-8.
1992: Rassnick S; Pulvirenti L; Koob G F
Oral ethanol self-administration in rats is reduced by the administration of dopamine and glutamate receptor antagonists into the nucleus accumbens.
Psychopharmacology 1992;109(1-2):92-8.
1992: Heinrichs S C; Koob G F
Corticotropin-releasing factor modulates dietary preference in nutritionally and physically stressed rats.
Psychopharmacology 1992;109(1-2):177-84.
1992: Markou A; Hauger R L; Koob G F
Desmethylimipramine attenuates cocaine withdrawal in rats.
Psychopharmacology 1992;109(3):305-14.
1992: Koob G F; Weiss F
Neuropharmacology of cocaine and ethanol dependence.
Recent developments in alcoholism : an official publication of the American Medical Society on Alcoholism, the Research Society on Alcoholism, and the National Council on Alcoholism 1992;10():201-33.
1992: Koob G F
Neurobiological mechanisms in cocaine and opiate dependence.
Research publications - Association for Research in Nervous and Mental Disease 1992;70():79-92.
1991: Pulvirenti L; Swerdlow N R; Koob G F
Nucleus accumbens NMDA antagonist decreases locomotor activity produced by cocaine, heroin or accumbens dopamine, but not caffeine.
Pharmacology, biochemistry, and behavior 1991;40(4):841-5.
1991: Heinrichs S C; Britton K T; Koob G F
Both conditioned taste preference and aversion induced by corticotropin-releasing factor.
Pharmacology, biochemistry, and behavior 1991;40(4):717-21.
1991: Baldwin H A; Wall T L; Schuckit M A; Koob G F
Differential effects of ethanol on punished responding in the P and NP rats.
Alcoholism, clinical and experimental research 1991;15(4):700-4.
1991: Swerdlow N R; Hauger R; Irwin M; Koob G F; Britton K T; Pulvirenti L
Endocrine, immune, and neurochemical changes in rats during withdrawal from chronic amphetamine intoxication.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1991;5(1):23-31.
1991: Britton K T; Page M; Baldwin H; Koob G F
Anxiolytic activity of steroid anesthetic alphaxalone.
The Journal of pharmacology and experimental therapeutics 1991;258(1):124-9.
1991: Weinger M B; Smith N T; Blasco T A; Koob G F
Brain sites mediating opiate-induced muscle rigidity in the rat: methylnaloxonium mapping study.
Brain research 1991;544(2):181-90.
1991: Schroeder R L; Weinger M B; Vakassian L; Koob G F
Methylnaloxonium diffuses out of the rat brain more slowly than naloxone after direct intracerebral injection.
Neuroscience letters 1991;121(1-2):173-7.
1991: Markou A; Koob G F
Postcocaine anhedonia. An animal model of cocaine withdrawal.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1991;4(1):17-26.
1991: Baldwin H A; Rassnick S; Rivier J; Koob G F; Britton K T
CRF antagonist reverses the "anxiogenic" response to ethanol withdrawal in the rat.
Psychopharmacology 1991;103(2):227-32.
1991: Koob G F; Swerdlow N R; Vaccarino F; Hubner C; Pulvirenti L; Weiss F
Functional output of the basal forebrain.
Advances in experimental medicine and biology 1991;295():291-305.
1990: Ehlers C L; Chaplin R I; Koob G F
EEG effects of Ro 15-4513 and FG 7142 alone and in combination with ethanol.
Pharmacology, biochemistry, and behavior 1990;36(3):607-11.
1990: Koob G F; Weiss F
Pharmacology of drug self-administration.
Alcohol (Fayetteville, N.Y.) 1990;7(3):193-7.
1990: Cole B J; Cador M; Stinus L; Rivier J; Vale W; Koob G F; Le Moal M
Central administration of a CRF antagonist blocks the development of stress-induced behavioral sensitization.
Brain research 1990;512(2):343-6.
1990: Weinger M B; Koob G F
What constitutes adequate anesthesia in animals? In neonates?
Anesthesiology 1990;72(4):767-9.
1990: Hubner C B; Koob G F
Bromocriptine produces decreases in cocaine self-administration in the rat.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1990;3(2):101-8.
1990: Pulvirenti L; Koob G F
The neural substrates of drug addiction and dependence.
Functional neurology 1990;5(2):109-19.
1990: Weinger M B; Schreiber J F; Koob G F
Effects of two benzodiazepine inverse agonists, RO 15-4513 and FG 7142, on recovery from pentobarbital and halothane anesthesia in the rat.
Pharmacology, biochemistry, and behavior 1990;35(4):889-95.
1990: Hurd Y L; Weiss F; Koob G; Ungerstedt U
The influence of cocaine self-administration on in vivo dopamine and acetylcholine neurotransmission in rat caudate-putamen.
Neuroscience letters 1990;109(1-2):227-33.
1990: Hubner C B; Koob G F
The ventral pallidum plays a role in mediating cocaine and heroin self-administration in the rat.
Brain research 1990;508(1):20-9.
1990: Weiss F; Mitchiner M; Bloom F E; Koob G F
Free-choice responding for ethanol versus water in alcohol preferring (P) and unselected Wistar rats is differentially modified by naloxone, bromocriptine, and methysergide.
Psychopharmacology 1990;101(2):178-86.
1990: Swerdlow N R; Mansbach R S; Geyer M A; Pulvirenti L; Koob G F; Braff D L
Amphetamine disruption of prepulse inhibition of acoustic startle is reversed by depletion of mesolimbic dopamine.
Psychopharmacology 1990;100(3):413-6.
1990: Melia K F; Koob G F; Ehlers C L
Ethanol effects on delayed spatial matching as modeled by a negative exponential forgetting function.
Psychopharmacology 1990;102(3):391-8.
1990: Cole B J; Cador M; Stinus L; Rivier C; Rivier J; Vale W; Le Moal M; Koob G F
Critical role of the hypothalamic pituitary adrenal axis in amphetamine-induced sensitization of behavior.
Life sciences 1990;47(19):1715-20.
1990: Stinus L; Le Moal M; Koob G F
Nucleus accumbens and amygdala are possible substrates for the aversive stimulus effects of opiate withdrawal.
Neuroscience 1990;37(3):767-73.
1990: Koob G F; Cole B J; Swerdlow N R; Le Moal M; Britton K T
Stress, performance, and arousal: focus on CRF.
NIDA research monograph 1990;97():163-76.
1989: Swerdlow N R; Britton K T; Koob G F
Potentiation of acoustic startle by corticotropin-releasing factor (CRF) and by fear are both reversed by alpha-helical CRF (9-41).
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1989;2(4):285-92.
1989: Unterwald E M; Tempel A; Koob G F; Zukin R S
Characterization of opioid receptors in rat nucleus accumbens following mesolimbic dopaminergic lesions.
Brain research 1989;505(1):111-8.
1989: Koob G F; Lebrun C; Bluthé R M; Dantzer R; Le Moal M
Role of neuropeptides in learning versus performance: focus on vasopressin.
Brain research bulletin 1989;23(4-5):359-64.
1989: Hurd Y L; Weiss F; Koob G F; And N E; Ungerstedt U
Cocaine reinforcement and extracellular dopamine overflow in rat nucleus accumbens: an in vivo microdialysis study.
Brain research 1989;498(1):199-203.
1989: Pulvirenti L; Swerdlow N R; Koob G F
Microinjection of a glutamate antagonist into the nucleus accumbens reduces psychostimulant locomotion in rats.
Neuroscience letters 1989;103(2):213-8.
1989: Swerdlow N R; Koob G F
Norepinephrine stimulates behavioral activation in rats following depletion of nucleus accumbens dopamine.
Pharmacology, biochemistry, and behavior 1989;33(3):595-9.
1989: Britton K T; Koob G F
Effects of corticotropin releasing factor, desipramine and haloperidol on a DRL schedule of reinforcement.
Pharmacology, biochemistry, and behavior 1989;32(4):967-70.
1989: Amalric M; Koob G F
Dorsal pallidum as a functional motor output of the corpus striatum.
Brain research 1989;483(2):389-94.
1989: Koob G F; Stinus L; Le Moal M; Bloom F E
Opponent process theory of motivation: neurobiological evidence from studies of opiate dependence.
Neuroscience and biobehavioral reviews 1989;13(2-3):135-40.
1989: Gold L H; Geyer M A; Koob G F
Psychostimulant properties of MDMA.
NIDA research monograph 1989;95():345-6.
1989: Weiss F; Ettenberg A; Koob G F
CCK-8 injected into the nucleus accumbens attenuates the supersensitive locomotor response to apomorphine in 6-OHDA and chronic-neuroleptic treated rats.
Psychopharmacology 1989;99(3):409-15.
1989: Gold L H; Koob G F
MDMA produces stimulant-like conditioned locomotor activity.
Psychopharmacology 1989;99(3):352-6.
1989: Gold L H; Hubner C B; Koob G F
A role for the mesolimbic dopamine system in the psychostimulant actions of MDMA.
Psychopharmacology 1989;99(1):40-7.
1989: Gold L H; Geyer M A; Koob G F
Neurochemical mechanisms involved in behavioral effects of amphetamines and related designer drugs.
NIDA research monograph 1989;94():101-26.
1989: Cole B J; Koob G F
Low doses of corticotropin-releasing factor potentiate amphetamine-induced stereotyped behavior.
Psychopharmacology 1989;99(1):27-33.
1989: Koob G F; Wall T L; Bloom F E
Nucleus accumbens as a substrate for the aversive stimulus effects of opiate withdrawal.
Psychopharmacology 1989;98(4):530-4.
1988: Cole B J; Koob G F
Propranolol antagonizes the enhanced conditioned fear produced by corticotropin releasing factor.
The Journal of pharmacology and experimental therapeutics 1988;247(3):902-10.
1988: Hand T H; Koob G F; Stinus L; Le Moal M
Aversive properties of opiate receptor blockade: evidence for exclusively central mediation in naive and morphine-dependent rats.
Brain research 1988;474(2):364-8.
1988: Koob G F; Percy L; Britton K T
The effects of Ro 15-4513 on the behavioral actions of ethanol in an operant reaction time task and a conflict test.
Pharmacology, biochemistry, and behavior 1988;31(3):757-60.
1988: Koob G F; Bloom F E
Cellular and molecular mechanisms of drug dependence.
Science (New York, N.Y.) 1988;242(4879):715-23.
1988: Gold L H; Koob G F; Geyer M A
Stimulant and hallucinogenic behavioral profiles of 3,4-methylenedioxymethamphetamine and N-ethyl-3,4-methylenedioxyamphetamine in rats.
The Journal of pharmacology and experimental therapeutics 1988;247(2):547-55.
1988: Koob G F; Mendelson W B; Schafer J; Wall T L; Britton K T; Bloom F E
Picrotoxinin receptor ligand blocks anti-punishment effects of alcohol.
Alcohol (Fayetteville, N.Y.) 1988;5(6):437-43.
1988: Dantzer R; Koob G F; Bluthé R M; Le Moal M
Septal vasopressin modulates social memory in male rats.
Brain research 1988;457(1):143-7.
1988: Gold L H; Swerdlow N R; Koob G F
The role of mesolimbic dopamine in conditioned locomotion produced by amphetamine.
Behavioral neuroscience 1988;102(4):544-52.
1988: Weinger M B; Cline E J; Smith N T; Blasco T A; Koob G F
Localization of brainstem sites which mediate alfentanil-induced muscle rigidity in the rat.
Pharmacology, biochemistry, and behavior 1988;29(3):573-80.
1988: Gold L H; Koob G F
Methysergide potentiates the hyperactivity produced by MDMA in rats.
Pharmacology, biochemistry, and behavior 1988;29(3):645-8.
1988: Britton K T; Ehlers C L; Koob G F
Is ethanol antagonist Ro15-4513 selective for ethanol?
Science (New York, N.Y.) 1988;239(4840):648-50.
1988: Dantzer R; Terlouw C; Tazi A; Koolhaas J M; Bohus B; Koob G F; Le Moal M
The propensity for schedule-induced polydipsia is related to differences in conditioned avoidance behaviour and in defense reactions in a defeat test.
Physiology & behavior 1988;43(3):269-73.
1988: Koob G F; Hubner C B
Reinforcement pathways for cocaine.
NIDA research monograph 1988;88():137-59.
1988: Britton K T; Lee G; Koob G F
Corticotropin releasing factor and amphetamine exaggerate partial agonist properties of benzodiazepine antagonist Ro 15-1788 in the conflict test.
Psychopharmacology 1988;94(3):306-11.
1988: Koob G F; Thatcher-Briton K; Tazi A; Le Moal M
Behavioral pharmacology of stress: Focus on CNS corticotropin-releasing factor.
Advances in experimental medicine and biology 1988;245():25-34.
1988: Koob G F; Swerdlow N R
The functional output of the mesolimbic dopamine system.
Annals of the New York Academy of Sciences 1988;537():216-27.
1988: Vaccarino F J; Feifel D; Rivier J; Vale W; Koob G F
Centrally administered hypothalamic growth hormone-releasing factor stimulates food intake in free-feeding rats.
Peptides 1988;9 Suppl 1():35-8.
1987: Koob G F; Wall T L; Schafer J
Rapid induction of tolerance to the antipunishment effects of ethanol.
Alcohol (Fayetteville, N.Y.) 1987;4(6):481-4.
1987: Weinger M B; Cline E J; Smith N T; Koob G F
Ketanserin pretreatment reverses alfentanil-induced muscle rigidity.
Anesthesiology 1987;67(3):348-54.
1987: Koob G F; Le H T; Creese I
The D1 dopamine receptor antagonist SCH 23390 increases cocaine self-administration in the rat.
Neuroscience letters 1987;79(3):315-20.
1987: Tazi A; Dantzer R; Le Moal M; Rivier J; Vale W; Koob G F
Corticotropin-releasing factor antagonist blocks stress-induced fighting in rats.
Regulatory peptides 1987;18(1):37-42.
1987: Tazi A; Swerdlow N R; LeMoal M; Rivier J; Vale W; Koob G F
Behavioral activation by CRF: evidence for the involvement of the ventral forebrain.
Life sciences 1987;41(1):41-9.
1987: Amalric M; Koob G F
Depletion of dopamine in the caudate nucleus but not in nucleus accumbens impairs reaction-time performance in rats.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1987;7(7):2129-34.
1987: Le Moal M; Dantzer R; Michaud B; Koob G F
Centrally injected arginine vasopressin (AVP) facilitates social memory in rats.
Neuroscience letters 1987;77(3):353-9.
1987: Swerdlow N R; Koob G F
Lesions of the dorsomedial nucleus of the thalamus, medial prefrontal cortex and pedunculopontine nucleus: effects on locomotor activity mediated by nucleus accumbens-ventral pallidal circuitry.
Brain research 1987;412(2):233-43.
1987: Swerdlow N R; Amalric M; Koob G F
Nucleus accumbens opiate-dopamine interactions and locomotor activation in the rat: evidence for a pre-synaptic locus.
Pharmacology, biochemistry, and behavior 1987;26(4):765-9.
1987: Lebrun C; Le Moal M; Dantzer R; Bloom F E; Koob G F
Hypertonic saline mimics the effects of vasopressin on inhibitory avoidance in the rat.
Behavioral and neural biology 1987;47(2):130-7.
1987: Koob G F
Neural substrates of opioid tolerance and dependence.
NIDA research monograph 1987;76():46-52.
1987: Dantzer R; Bluthe R M; Koob G F; Le Moal M
Modulation of social memory in male rats by neurohypophyseal peptides.
Psychopharmacology 1987;91(3):363-8.
1987: Amalric M; Cline E J; Martinez J L; Bloom F E; Koob G F
Rewarding properties of beta-endorphin as measured by conditioned place preference.
Psychopharmacology 1987;91(1):14-9.
1986: Thatcher-Britton K; Koob G F
Alcohol reverses the proconflict effect of corticotropin-releasing factor.
Regulatory peptides 1986;16(3-4):315-20.
1986: Amalric M; Koob G F; Creese I; Swerdlow N R
"Selective" D-1 and D-2 receptor antagonists fail to differentially alter supersensitive locomotor behavior in the rat.
Life sciences 1986;39(21):1985-93.
1986: Britton K T; Lee G; Dana R; Risch S C; Koob G F
Activating and 'anxiogenic' effects of corticotropin releasing factor are not inhibited by blockade of the pituitary-adrenal system with dexamethasone.
Life sciences 1986;39(14):1281-6.
1986: Blasco T A; Lee D; Amalric M; Swerdlow N R; Smith N T; Koob G F
The role of the nucleus raphe pontis and the caudate nucleus in alfentanil rigidity in the rat.
Brain research 1986;386(1-2):280-6.
1986: Amalric M; Blasco T A; Smith N T; Lee D E; Swerdlow N R; Koob G F
'Catatonia' produced by alfentanil is reversed by methylnaloxonium microinjections into the brain.
Brain research 1986;386(1-2):287-95.
1986: Downs N S; Britton K T; Gibbs D M; Koob G F; Swerdlow N R
Supersensitive endocrine response to physostigmine in dopamine-depleted rats: a model of depression?
Biological psychiatry 1986;21(8-9):775-86.
1986: Swerdlow N R; Vaccarino F J; Amalric M; Koob G F
The neural substrates for the motor-activating properties of psychostimulants: a review of recent findings.
Pharmacology, biochemistry, and behavior 1986;25(1):233-48.
1986: Melia K F; Ehlers C L; LeBrun C J; Koob G F
Post-learning ethanol effects on a water-finding task in rats.
Pharmacology, biochemistry, and behavior 1986;24(6):1813-5.
1986: Koob G F; Dantzer R; Bluthé R M; Lebrun C; Bloom F E; Le Moal M
Central injections of arginine vasopressin prolong extinction of active avoidance.
Peptides 1986;7(2):213-8.
1986: Britton K T; Lee G; Vale W; Rivier J; Koob G F
Corticotropin releasing factor (CRF) receptor antagonist blocks activating and 'anxiogenic' actions of CRF in the rat.
Brain research 1986;369(1-2):303-6.
1986: Vaccarino F J; Amalric M; Swerdlow N R; Koob G F
Blockade of amphetamine but not opiate-induced locomotion following antagonism of dopamine function in the rat.
Pharmacology, biochemistry, and behavior 1986;24(1):61-5.
1986: Swerdlow N R; Braff D L; Geyer M A; Koob G F
Central dopamine hyperactivity in rats mimics abnormal acoustic startle response in schizophrenics.
Biological psychiatry 1986;21(1):23-33.
1986: Deyo S N; Shoemaker W J; Ettenberg A; Bloom F E; Koob G F
Subcutaneous administration of behaviorally effective doses of arginine vasopressin change brain AVP content only in median eminence.
Neuroendocrinology 1986;42(3):260-6.
1986: Swerdlow N R; Koob G F; Aldenhoff J B
The effects of verapamil on the locomotor-activating properties of corticotropin releasing factor (CRF) in the rat.
Psychoneuroendocrinology 1986;11(2):237-40.
1986: Koob G F; Braestrup C; Thatcher Britton K
The effects of FG 7142 and RO 15-1788 on the release of punished responding produced by chlordiazepoxide and ethanol in the rat.
Psychopharmacology 1986;90(2):173-8.
1986: Swerdlow N R; Geyer M A; Vale W W; Koob G F
Corticotropin-releasing factor potentiates acoustic startle in rats: blockade by chlordiazepoxide.
Psychopharmacology 1986;88(2):147-52.
1986: Koob G F; Vaccarino F J; Amalric M; Bloom F E
Neurochemical substrates for opiate reinforcement.
NIDA research monograph 1986;71():146-64.
1985: Swerdlow N R; Lee D; Koob G F; Vaccarino F J
Effects of chronic dietary lithium on behavioral indices of dopamine denervation supersensitivity in the rat.
The Journal of pharmacology and experimental therapeutics 1985;235(2):324-9.
1985: Swerdlow N R; Vaccarino F J; Koob G F
Effects of naloxone on heroin-, amphetamine- and caffeine-stimulated locomotor activity in the rat.
Pharmacology, biochemistry, and behavior 1985;23(3):499-501.
1985: Vaccarino F J; Pettit H O; Bloom F E; Koob G F
Effects of intracerebroventricular administration of methyl naloxonium chloride on heroin self-administration in the rat.
Pharmacology, biochemistry, and behavior 1985;23(3):495-8.
1985: Amalric M; Koob G F
Low doses of methylnaloxonium in the nucleus accumbens antagonize hyperactivity induced by heroin in the rat.
Pharmacology, biochemistry, and behavior 1985;23(3):411-5.
1985: Eaves M; Thatcher-Britton K; Rivier J; Vale W; Koob G F
Effects of corticotropin releasing factor on locomotor activity in hypophysectomized rats.
Peptides 1985;6(5):923-6.
1985: Swerdlow N R; Koob G F
Separate neural substrates of the locomotor-activating properties of amphetamine, heroin, caffeine and corticotropin releasing factor (CRF) in the rat.
Pharmacology, biochemistry, and behavior 1985;23(2):303-7.
1985: Lebrun C; Le Moal M; Koob G F; Bloom F E
Vasopressin pressor antagonist injected centrally reverses behavioral effects of peripheral injection of vasopressin, but only at doses that reverse increase in blood pressure.
Regulatory peptides 1985;11(2):173-81.
1985: Koob G F; Dantzer R; Rodriguez F; Bloom F E; Le Moal M
Osmotic stress mimics effects of vasopressin on learned behaviour.
Nature 1985;315(6022):750-2.
1985: Vaccarino F J; Bloom F E; Rivier J; Vale W; Koob G F
Stimulation of food intake in rats by centrally administered hypothalamic growth hormone-releasing factor.
Nature 1985;314(6007):167-8.
1985: Ehlers C L; Koob G F
Locomotor behavior following kindling in three different brain sites.
Brain research 1985;326(1):71-9.
1985: Koob G F; Bloom F E
Corticotropin-releasing factor and behavior.
Federation proceedings 1985;44(1 Pt 2):259-63.
1985: Ehlers C L; Koob G F
The effects of chronic lithium on the EEG and locomotor response to drug challenge in rats.
Progress in neuro-psychopharmacology & biological psychiatry 1985;9(2):133-42.
1985: Ehlers C L; Reed T K; Wang M; Lebrun C J; Koob G F
EEG effects of subcutaneous and intracerebroventricular injections of arginine vasopressin in the rat.
Psychopharmacology 1985;87(4):430-3.
1985: Britton K T; Morgan J; Rivier J; Vale W; Koob G F
Chlordiazepoxide attenuates response suppression induced by corticotropin-releasing factor in the conflict test.
Psychopharmacology 1985;86(1-2):170-4.
1985: Koob G F; Thatcher-Britton K
Stimulant and anxiogenic effects of corticotropin releasing factor.
Progress in clinical and biological research 1985;192():499-506.
1985: Koob G F; Lebrun C; Martinez J L; Dantzer R; Le Moal M; Bloom F E
Arginine vasopressin, stress, and memory.
Annals of the New York Academy of Sciences 1985;444():194-202.
1985: Vaccarino F J; Bloom F E; Koob G F
Blockade of nucleus accumbens opiate receptors attenuates intravenous heroin reward in the rat.
Psychopharmacology 1985;86(1-2):37-42.
1984: Swerdlow N R; Koob G F
The neural substrates of apomorphine-stimulated locomotor activity following denervation of the nucleus accumbens.
Life sciences 1984;35(25):2537-44.
1984: Vaccarino F J; Koob G F
Microinjections of nanogram amounts of sulfated cholecystokinin octapeptide into the rat nucleus accumbens attenuates brain stimulation reward.
Neuroscience letters 1984;52(1-2):61-6.
1984: Koob G F; Swerdlow N; Seeligson M; Eaves M; Sutton R; Rivier J; Vale W
Effects of alpha-flupenthixol and naloxone on CRF-induced locomotor activation.
Neuroendocrinology 1984;39(5):459-64.
1984: LeBrun C J; Rigter H; Martinez J L; Koob G F; Le Moal M; Bloom F E
Antagonism of effects of vasopressin (AVP) on inhibitory avoidance by a vasopressin antagonist peptide [dPtyr(Me)AVP].
Life sciences 1984;35(14):1505-12.
1984: Moss D E; Koob G F; McMaster S B; Janowsky D S
Comparative effects of tetrahydrocannabinol on psychostimulant-induced behaviors.
Pharmacology, biochemistry, and behavior 1984;21(4):641-4.
1984: Koob G F; Thatcher-Britton K; Britton D R; Roberts D C; Bloom F E
Destruction of the locus coeruleus or the dorsal NE bundle does not alter the release of punished responding by ethanol and chlordiazepoxide.
Physiology & behavior 1984;33(3):479-85.
1984: Swerdlow N R; Swanson L W; Koob G F
Substantia innominata: critical link in the behavioral expression of mesolimbic dopamine stimulation in the rat.
Neuroscience letters 1984;50(1-3):19-24.
1984: Britton D R; Ksir C; Britton K T; Young D; Koob G F
Brain norepinephrine depleting lesions selectively enhance behavioral responsiveness to novelty.
Physiology & behavior 1984;33(3):473-8.
1984: Swerdlow N R; Swanson L W; Koob G F
Electrolytic lesions of the substantia innominata and lateral preoptic area attenuate the 'supersensitive' locomotor response to apomorphine resulting from denervation of the nucleus accumbens.
Brain research 1984;306(1-2):141-8.
1984: Koob G F; Simon H; Herman J P; Le Moal M
Neuroleptic-like disruption of the conditioned avoidance response requires destruction of both the mesolimbic and nigrostriatal dopamine systems.
Brain research 1984;303(2):319-29.
1984: Koob G F; Pettit H O; Ettenberg A; Bloom F E
Effects of opiate antagonists and their quaternary derivatives on heroin self-administration in the rat.
The Journal of pharmacology and experimental therapeutics 1984;229(2):481-6.
1984: Ettenberg A; Koob G F
Different effects of cholecystokinin and satiety on lateral hypothalamic self-stimulation.
Physiology & behavior 1984;32(1):127-30.
1984: Britton K T; Svensson T; Schwartz J; Bloom F E; Koob G F
Dorsal noradrenergic bundle lesions fail to alter opiate withdrawal or suppression of opiate withdrawal by clonidine.
Life sciences 1984;34(2):133-9.
1984: Le Moal M; Dantzer R; Mormède P; Baduel A; Lebrun C; Ettenberg A; van der Kooy D; Wenger J; Deyo S; Koob G F
Behavioral effects of peripheral administration of arginine vasopressin: a review of our search for a mode of action and a hypothesis.
Psychoneuroendocrinology 1984;9(4):319-41.
1984: Pettit H O; Ettenberg A; Bloom F E; Koob G F
Destruction of dopamine in the nucleus accumbens selectively attenuates cocaine but not heroin self-administration in rats.
Psychopharmacology 1984;84(2):167-73.
1984: Swerdlow N R; Koob G F
Restrained rats learn amphetamine-conditioned locomotion, but not place preference.
Psychopharmacology 1984;84(2):163-6.
1984: Aston-Jones S; Aston-Jones G; Koob G F
Cocaine antagonizes anxiolytic effects of ethanol.
Psychopharmacology 1984;84(1):28-31.
1983: Swerdlow N R; van der Kooy D; Koob G F; Wenger J R
Cholecystokinin produces conditioned place-aversions, not place-preferences, in food-deprived rats: evidence against involvement in satiety.
Life sciences 1983;32(18):2087-93.
1983: Ettenberg A; Le Moal M; Koob G F; Bloom F E
Vasopressin potentiation in the performance of a learned appetitive task: reversal by a pressor antagonist analog of vasopressin.
Pharmacology, biochemistry, and behavior 1983;18(4):645-7.
1983: Ettenberg A; van der Kooy D; Le Moal M; Koob G F; Bloom F E
Can aversive properties of (peripherally-injected) vasopressin account for its putative role in memory?
Behavioural brain research 1983;7(3):331-50.
1983: Robbins T W; Roberts D C; Koob G F
Effects of d-amphetamine and apomorphine upon operant behavior and schedule-induced licking in rats with 6-hydroxydopamine-induced lesions of the nucleus accumbens.
The Journal of pharmacology and experimental therapeutics 1983;224(3):662-73.
1983: van der Kooy D; Swerdlow N R; Koob G F
Paradoxical reinforcing properties of apomorphine: effects of nucleus accumbens and area postrema lesions.
Brain research 1983;259(1):111-8.
1983: Koob G F; Bloom F E
Behavioural effects of opioid peptides.
British medical bulletin 1983;39(1):89-94.
1983: Ehlers C L; Indik J H; Koob G F; Bloom F E
The effect of single and repeated electroconvulsive shock (ECS) on locomotor activity in rats.
Progress in neuro-psychopharmacology & biological psychiatry 1983;7(2-3):217-22.
1983: Vale W; Rivier C; Brown M R; Spiess J; Koob G; Swanson L; Bilezikjian L; Bloom F; Rivier J
Chemical and biological characterization of corticotropin releasing factor.
Recent progress in hormone research 1983;39():245-70.
1982: Roberts D C; Koob G F
Disruption of cocaine self-administration following 6-hydroxydopamine lesions of the ventral tegmental area in rats.
Pharmacology, biochemistry, and behavior 1982;17(5):901-4.
1982: Strecker R E; Roberts D C; Koob G F
Apomorphine-induced facilitation of intracranial self-stimulation following dopamine denervation of the nucleus accumbens.
Pharmacology, biochemistry, and behavior 1982;17(5):1015-8.
1982: Fray P J; Koob G F; Iversen S D
Tail-pinch-elicited behavior in rats: preference, plasticity, and learning.
Behavioral and neural biology 1982;36(2):108-25.
1982: Ehlers C L; Koob G F; Bloom F E
Post-ictal locomotor activity in three different rat models of epilepsy.
Brain research 1982;250(1):178-82.
1982: Schwartz J M; Ksir C; Koob G F; Bloom F E
Changes in locomotor response to beta-endorphin microinfusion during and after opiate abstinence syndrome--a proposal for a model of the onset of mania.
Psychiatry research 1982;7(2):153-61.
1982: Staunton D A; Magistretti P J; Koob G F; Shoemaker W J; Bloom F E
Dopaminergic supersensitivity induced by denervation and chronic receptor blockade is additive.
Nature 1982;299(5878):72-4.
1982: Britton D R; Koob G F; Rivier J; Vale W
Intraventricular corticotropin-releasing factor enhances behavioral effects of novelty.
Life sciences 1982;31(4):363-7.
1982: Sutton R E; Koob G F; Le Moal M; Rivier J; Vale W
Corticotropin releasing factor produces behavioural activation in rats.
Nature 1982;297(5864):331-3.
1982: Koob G F; Bloom F E
Behavioral effects of neuropeptides: endorphins and vasopressin.
Annual review of physiology 1982;44():571-82.
1982: Ettenberg A; Pettit H O; Bloom F E; Koob G F
Heroin and cocaine intravenous self-administration in rats: mediation by separate neural systems.
Psychopharmacology 1982;78(3):204-9.
1981: Koob G F; Stinus L; Le Moal M
Hyperactivity and hypoactivity produced by lesions to the mesolimbic dopamine system.
Behavioural brain research 1981;3(3):341-59.
1981: Joyce E M; Koob G F; Strecker R; Iversen S D; Bloom F E
The behavioural effects of enkephalin analogues injected into the ventral tegmental area and globus pallidus.
Brain research 1981;221(2):359-70.
1981: Ettenberg A; Rogers J; Koob G F; Bloom F E; Deutsch J A
Endogenous opiates and fasting.
Science (New York, N.Y.) 1981;213(4513):1282.
1981: Ettenberg A; Koob G F; Bloom F E
Response artifact in the measurement of neuroleptic-induced anhedonia.
Science (New York, N.Y.) 1981;213(4505):357-9.
1981: Koob G F; Le Moal M; Gaffori O; Manning M; Sawyer W H; Rivier J; Bloom F E
Arginine vasopressin and a vasopressin antagonist peptide: opposite effects on extinction of active avoidance in rats.
Regulatory peptides 1981;2(3):153-63.
1981: Le Moal M; Koob G F; Koda L Y; Bloom F E; Manning M; Sawyer W H; Rivier J
Vasopressor receptor antagonist prevents behavioural effects of vasopressin.
Nature 1981;291(5815):491-3.
1981: Joyce E M; Koob G F
Amphetamine-, scopolamine- and caffeine-induced locomotor activity following 6-hydroxydopamine lesions of the mesolimbic dopamine system.
Psychopharmacology 1981;73(4):311-3.
1980: Robbins T W; Koob G F
Selective disruption of displacement behaviour by lesions of the mesolimbic dopamine system.
Nature 1980;285(5764):409-12.
1980: Roberts D C; Koob G F; Klonoff P; Fibiger H C
Extinction and recovery of cocaine self-administration following 6-hydroxydopamine lesions of the nucleus accumbens.
Pharmacology, biochemistry, and behavior 1980;12(5):781-7.
1980: Sessions G R; Meyerhoff J L; Kant G J; Koob G F
Effects of lesions of the ventral medial tegmentum on locomotor activity, biogenic amines and responses to amphetamine in rats.
Pharmacology, biochemistry, and behavior 1980;12(4):603-8.
1980: Stinus L; Koob G F; Ling N; Bloom F E; Le Moal M
Locomotor activation induced by infusion of endorphins into the ventral tegmental area: evidence for opiate-dopamine interactions.
Proceedings of the National Academy of Sciences of the United States of America 1980;77(4):2323-7.
1980: Koob G F; Strecker R E; Bloom F E
Effects of naloxone on the anticonflict properties of alcohol and chlordiazepoxide.
Substance and alcohol actions/misuse 1980;1(5-6):447-57.
1980: Bloom F; Bayon A; Battenberg E; French E; Koda L; Koob G; Le Moal M; Rossier J; Shoemaker W
Endorphins: developmental, cellular, and behavioral aspects.
Advances in biochemical psychopharmacology 1980;22():619-32.
1980: Fray P J; Sahakian B J; Robbins T W; Koob G F; Iversen S D
An observational method for quantifying the behavioural effects of dopamine agonists: contrasting effects of d-amphetamine and apomorphine.
Psychopharmacology 1980;69(3):253-9.
1979: Le Moal M; Koob G F; Bloom F E
Endorphins and extinction: differential actions on appetitive and adversive tasks.
Life sciences 1979;24(18):1631-6.
1978: Koda L Y; Koob G F; Shier W T; Bloom F E
Tetrahydropapaveroline induces small granular vesicles in brain dopamine fibres.
Nature 1978;276(5685):281-3.
1978: Koob G F; Riley S J; Smith S C; Robbins T W
Effects of 6-hydroxydopamine lesions of the nucleus accumbens septi and olfactory tubercle on feeding, locomotor activity, and amphetamine anorexia in the rat.
Journal of comparative and physiological psychology 1978;92(5):917-27.
1978: Koob G F; Kelley A E; Mason S T
Locus coeruleus lesions: learning and extinction.
Physiology & behavior 1978;20(6):709-16.
1978: Sahakian B J; Koob G F
The relationship between pipradrol-induced responding for electrical brain stimulation, stereotyped behaviour and locomotor activity.
Neuropharmacology 1978;17(6):363-6.
1978: Koob G F; Fray P J; Iversen S D
Self-stimulation at the lateral hypothalamus and locus coeruleus after specific unilateral lesions of the dopamine system.
Brain research 1978;146(1):123-40.
1978: Koob G F; Del Fiacco M; Iversen S D
Spontaneous and amphetamine-induced behavior after bilateral injection of ethanolamine-O-sulfate into the substantia nigra.
Brain research 1978;146(2):313-23.
1978: Robbins T W; Koob G F
Pipradrol enhances reinforcing properties of stimuli paired with brain stimulation.
Pharmacology, biochemistry, and behavior 1978;8(3):219-22.
1978: Emson P C; Koob G F
The origin and distribution of dopamine-containing afferents to the rat frontal cortex.
Brain research 1978;142(2):249-67.
1977: Koob G F; Winger G D; Meyerhoff J L; Annau Z
Effects of D-amphetamine on concurrent self-stimulation of forebrain and brain stem loci.
Brain research 1977;137(1):109-26.
1977: Emson P C; Koob G; Iversen L L
Origin of dopaminergic afferents to the rat frontal cortex [proceedings]
British journal of pharmacology 1977;60(2):270P-271P.
1977: Koob G F
Incentive shifts in intracranial self-stimulation produced by different series of stimulus intensity presentations.
Physiology & behavior 1977;18(1):131-5.
1977: Koob G F; Del Fiacco M; Iversen S D
Dissociable properties of dopamine neurons im the nigrostriatal and mesolimbic dopamine systems.
Advances in biochemical psychopharmacology 1977;16():589-95.
1977: Iversen S D; Koob G F
Behavioral implications of dopaminergic neurons in the mesolimbic system.
Advances in biochemical psychopharmacology 1977;16():209-14.
1976: Sessions G R; Kant G J; Koob G F
Locus coeruleus lesions and learning in the rat.
Physiology & behavior 1976;17(5):853-9.
1976: Koob G; del Fiacco M; Iversen S D
The behavioural effects of EOS-induced changes in substantia nigra GABA levels [proceedings].
British journal of pharmacology 1976;58(3):454P.
1976: Koob G F; Fray P J; Iversen S D
Tail-pinch stimulation: sufficient motivation for learning.
Science (New York, N.Y.) 1976;194(4265):637-9.
1976: Koob G F; Sessions G R; Kant G J; Meyerhoff J L
Dissociation of hyperdipsia from the destruction of the locus coeruleus in rats.
Brain research 1976;116(2):339-45.
1976: Koob G F; Balcom G J; Meyerhoff J L
Increases in intracranial self-stimulation in the posterior hypothalamus following unilateral lesions in the locus coeruleus.
Brain research 1976;101(3):554-60.
1975: Koob G F; Balcom G J; Meyerhoff J L
Dopamine and norepinephrine levels in the nucleus accumbens, olfactory tubercle and corpus striatum following lesions in the ventral tegmentalarea.
Brain research 1975;94(1):45-55.
1975: Koob G F; Spector N H; Meyerhoff J L
Effects of heroin on lever pressing for intracranial self-stimulation, food and water in the rat.
Psychopharmacologia 1975;42(3):231-4.
1974: Annau Z; Heffner R; Koob G F
Electrical self-stimulation of single and multiple loci: long term observations.
Physiology & behavior 1974;13(2):281-90.
1974: Koob G F; Annau Z
Behavioral and neurochemical alterations induced by hypoxia in rats.
The American journal of physiology 1974;227(1):73-8.
1974: Koob G F; Annau Z; Rubin R J; Montgomery M R
Effect of hypoxic hypoxia and carbon monoxide on food intake, water intake, and body weight in two strains of rats.
Life sciences 1974;14(8):1511-20.
1973: Koob G F; Annau Z
Effect of hypoxia on hypothalamic mechanisms.
The American journal of physiology 1973;224(6):1403-8.

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