FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

George Koob

Research Profile

Living Beings

Procedures

Chemicals & Drugs

Disorders

Activities & Behaviors

Concepts & Ideas

Drug Dose Response Relationship

Physiology

Conditioning, Operant

Anatomy

Co-author Network

Publications

TOP 3
Xiaoqing Cai; Yanabel Grant; Mark Hixon; George F Koob; Timothy Whitfield; Kim D Janda
Probing Active Cocaine Vaccination Performance through Catalytic and Noncatalytic Hapten Design.
Estelle Barbier; Kejun Cheng; Scott Edwards; Nathan Juergens; George F Koob; Kaushik K Misra; Paula E Park; Kenner C Rice; Jesse Schank; Joel E Schlosburg; Gery Schulteis; Leandro F Vendruscolo; Markus Heilig
The NK1 receptor antagonist l822429 reduces heroin reinforcement.
Melissa A Herman; Marsida Kallupi; George F Koob; George Luu; Christopher S Oleata; Roberto Ciccocioppo; Markus Heilig; Marisa Roberto
Enhanced GABAergic transmission in the central nucleus of the amygdala of genetically selected Marchigian Sardinian rats: Alcohol and CRF effects.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of George Koob (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Xiaoqing Cai; Yanabel Grant; Mark Hixon; George F Koob; Timothy Whitfield; Kim D Janda
Probing Active Cocaine Vaccination Performance through Catalytic and Noncatalytic Hapten Design.
Journal of medicinal chemistry 2013;56(9):3701-9.
2013: Estelle Barbier; Kejun Cheng; Scott Edwards; Nathan Juergens; George F Koob; Kaushik K Misra; Paula E Park; Kenner C Rice; Jesse Schank; Joel E Schlosburg; Gery Schulteis; Leandro F Vendruscolo; Markus Heilig
The NK1 receptor antagonist l822429 reduces heroin reinforcement.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2013;38(6):976-84.
2013: Melissa A Herman; Marsida Kallupi; George F Koob; George Luu; Christopher S Oleata; Roberto Ciccocioppo; Markus Heilig; Marisa Roberto
Enhanced GABAergic transmission in the central nucleus of the amygdala of genetically selected Marchigian Sardinian rats: Alcohol and CRF effects.
Neuropharmacology 2013;67():337-48.
2013: olivier george; George F Koob
Control of craving by the prefrontal cortex.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(11):4165-6.
2013: Choon-Gon Jang; George F Koob; Gery Schulteis; Timothy Whitfield; Sunmee Wee
A dysphoric-like state during early withdrawal from extended access to methamphetamine self-administration in rats.
Psychopharmacology 2013;225(3):753-63.
2013: Bishnu P De; Martin J Hicks; Kim D Janda; Stephen M Kaminsky; George F Koob; Amira Y Moreno; Odelya E Pagovich; Jonathan B Rosenberg; Dolan Sondhi; Stefan Worgall; Ronald G Crystal
Disrupted adenovirus-based vaccines against small addictive molecules circumvent anti-adenovirus immunity.
Human gene therapy 2013;24(1):58-66.
2013: George F Koob
Theoretical frameworks and mechanistic aspects of alcohol addiction: alcohol addiction as a reward deficit disorder.
Current topics in behavioral neurosciences 2013;13():3-30.
2012: Mark Egli; George F Koob; Scott Edwards
Alcohol dependence as a chronic pain disorder.
Neuroscience and biobehavioral reviews 2012;36(10):2179-92.
2012: Magalie Lenoir; Karyn Guillem; George F Koob; Serge H Ahmed
Drug specificity in extended access cocaine and heroin self-administration.
Addiction biology 2012;17(6):964-76.
2012: olivier george; Edward Grigoryan; Camryn D Allen; Elena Crawford; John Freiling; Chitra D Mandyam; Chelsea Sanders; Shayla Vu; George F Koob
Recruitment of medial prefrontal cortex neurons during alcohol withdrawal predicts cognitive impairment and excessive alcohol drinking.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(44):18156-61.
2012: Amira Y Moreno; George F Koob; Marc R Azar; Kim D Janda
Probing the protective effects of a conformationally constrained nicotine vaccine.
Vaccine 2012;30(47):6665-70.
2012: Nick E Goeders; Marc R Azar; Ami Cohen; Barbara S Fox; olivier george; George F Koob
Effects of the combination of metyrapone and oxazepam on intravenous nicotine self-administration in rats.
Psychopharmacology 2012;223(1):17-25.
2012: Sunmee Wee; Kaushik K Misra; Joel E Schlosburg; Leandro F Vendruscolo; George F Koob
A combination of buprenorphine and naltrexone blocks compulsive cocaine intake in rodents without producing dependence.
Science translational medicine 2012;4(146):146ra110.
2012: Ami Cohen; George F Koob; olivier george
Robust escalation of nicotine intake with extended access to nicotine self-administration and intermittent periods of abstinence.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2012;37(9):2153-60.
2012: Leandro F Vendruscolo; Timothy W Whitfield; Eric P Zorrilla; Estelle Barbier; Markus Heilig; Marian L Logrip; Kaushik K Misra; Vez Repunte-Canonigo; Catherine Rivier; Pietro P Sanna; Joel E Schlosburg; George F Koob
Corticosteroid-dependent plasticity mediates compulsive alcohol drinking in rats.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(22):7563-71.
2012: Jonathan B Rosenberg; Nicole Tignor; Sunmee Wee; Stefan Worgall; Bishnu P De; Esther Frenk; Neil R Hackett; Martin J Hicks; Kim D Janda; Stephen M Kaminsky; George F Koob; Jason G Mezey; Odelya Pagovich; Ronald G Crystal
AAVrh.10-mediated expression of an anti-cocaine antibody mediates persistent passive immunization that suppresses cocaine-induced behavior.
Human gene therapy 2012;23(5):451-9.
2012: Olivier George; Michel Le Moal; George F Koob
Allostasis and addiction: role of the dopamine and corticotropin-releasing factor systems.
Physiology & behavior 2012;106(1):58-64.
2012: Chitra D Mandyam; George F Koob
The addicted brain craves new neurons: putative role for adult-born progenitors in promoting recovery.
Trends in neurosciences 2012;35(4):250-60.
2012: Patrick Recinto; Anjali Rose H Samant; Matthew Soleiman; Sunmee Wee; Clara J Yuan; Gustavo Chavez; Scott Edwards; olivier george; Yanabel Grant; Airee Kim; George F Koob; Chitra D Mandyam
Levels of neural progenitors in the hippocampus predict memory impairment and relapse to drug seeking as a function of excessive methamphetamine self-administration.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2012;37(5):1275-87.
2012: Sunmee Wee; Amira Y Moreno; Jonathan B Rosenberg; Ronald G Crystal; Bishnu P De; Martin J Hicks; Kim D Janda; Stephen M Kaminsky; George F Koob
Novel cocaine vaccine linked to a disrupted adenovirus gene transfer vector blocks cocaine psychostimulant and reinforcing effects.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2012;37(5):1083-91.
2012: Eric P Zorrilla; Yu Zhao; Benjamin Boutrel; George F Koob; Sheila Specio; Sunmee Wee; Friedbert Weiss
Extended access cocaine self-administration differentially activates dorsal raphe and amygdala corticotropin-releasing factor systems in rats.
Addiction biology 2012;17(2):300-8.
2012: Scott Edwards; Kaushik K Misra; Paula E Park; Joel E Schlosburg; Gery Schulteis; Leandro F Vendruscolo; Sunmee Wee; George F Koob
Development of mechanical hypersensitivity in rats during heroin and ethanol dependence: alleviation by CRF₁ receptor antagonism.
Neuropharmacology 2012;62(2):1142-51.
2012: Marian L Logrip; Eric P Zorrilla; George F Koob
Stress modulation of drug self-administration: implications for addiction comorbidity with post-traumatic stress disorder.
Neuropharmacology 2012;62(2):552-64.
2012: Amanda E Higley; George F Koob; Barbara J Mason
Treatment of alcohol dependence with drug antagonists of the stress response.
Alcohol research : current reviews 2012;34(4):516-21.
2012: George F Koob
Animal models of psychiatric disorders.
Handbook of clinical neurology 2012;106():137-66.
2011: G Neilm Stowe; Leandro F Vendruscolo; Joseph S Zakhari; Scott Edwards; George F Koob; Kaushik K Misra; Joel E Schlosburg; Gery Schulteis; Kim D Janda
Developing a vaccine against multiple psychoactive targets: a case study of heroin.
CNS & neurological disorders drug targets 2011;10(8):865-75.
2011: Candice Contet; Dominique Filliol; Olivier Gardon; Jérôme A J Becker; George F Koob; Brigitte L Kieffer
Identification of genes regulated in the mouse extended amygdala by excessive ethanol drinking associated with dependence.
Addiction biology 2011;16(4):615-9.
2011: Claudia Mihindou; Caroline Vouillac; George F Koob; Serge H Ahmed
Preclinical validation of a novel cocaine exposure therapy for relapse prevention.
Biological psychiatry 2011;70(6):593-8.
2011: G Neil Stowe; Leandro F Vendruscolo; Joseph S Zakhari; Scott Edwards; George F Koob; Alexander V Mayorov; Kaushik K Misra; Joel E Schlosburg; Gery Schulteis; Kim D Janda
A vaccine strategy that induces protective immunity against heroin.
Journal of medicinal chemistry 2011;54(14):5195-204.
2011: Sarah L Parylak; George F Koob; Eric P Zorrilla
The dark side of food addiction.
Physiology & behavior 2011;104(1):149-56.
2011: Nicholas W Gilpin; Kaushik Misra; Melissa A Herman; Maureen T Cruz; George F Koob; Marisa Roberto
Neuropeptide Y opposes alcohol effects on gamma-aminobutyric acid release in amygdala and blocks the transition to alcohol dependence.
Biological psychiatry 2011;69(11):1091-9.
2011: Leandro F Vendruscolo; Joel E Schlosburg; Kaushik K Misra; Scott A Chen; Thomas N Greenwell; George F Koob
Escalation patterns of varying periods of heroin access.
Pharmacology, biochemistry, and behavior 2011;98(4):570-4.
2011: Camryn D Allen; Soon Lee; George F Koob; Catherine Rivier
Immediate and prolonged effects of alcohol exposure on the activity of the hypothalamic-pituitary-adrenal axis in adult and adolescent rats.
Brain, behavior, and immunity 2011;25 Suppl 1():S50-60.
2011: Valentina Sabino; Pietro Cottone; Angelo Blasio; Malliga R Iyer; Luca Steardo; Kenner C Rice; Bruno Conti; George F Koob; Eric P Zorrilla
Activation of σ-receptors induces binge-like drinking in Sardinian alcohol-preferring rats.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2011;36(6):1207-18.
2011: Olivier George; George F Koob
Craving, context and the cortex.
Nature neuroscience 2011;14(4):409-10.
2011: Marian L Logrip; George F Koob; Eric P Zorrilla
Role of corticotropin-releasing factor in drug addiction: potential for pharmacological intervention.
CNS drugs 2011;25(4):271-87.
2011: Martin J Hicks; Bishnu P De; Jonathan B Rosenberg; Jesse T Davidson; Amira Y Moreno; Kim D Janda; Sunmee Wee; George F Koob; Neil R Hackett; Stephen M Kaminsky; Stefan Worgall; Miklos Toth; Jason G Mezey; Ronald G Crystal
Cocaine analog coupled to disrupted adenovirus: a vaccine strategy to evoke high-titer immunity against addictive drugs.
Molecular therapy : the journal of the American Society of Gene Therapy 2011;19(3):612-9.
2011: olivier george; Allison Lloyd; F Ivy Carroll; M Imad Damaj; George F Koob
Varenicline blocks nicotine intake in rats with extended access to nicotine self-administration.
Psychopharmacology 2011;213(4):715-22.
2011: John C Crabbe; R Adron Harris; George F Koob
Preclinical studies of alcohol binge drinking.
Annals of the New York Academy of Sciences 2011;1216():24-40.
2011: Brendan M Walker; Eric P Zorrilla; George F Koob
Systemic κ-opioid receptor antagonism by nor-binaltorphimine reduces dependence-induced excessive alcohol self-administration in rats.
Addiction biology 2011;16(1):116-9.
2010: Olivier George; George F Koob
Individual differences in prefrontal cortex function and the transition from drug use to drug dependence.
Neuroscience and biobehavioral reviews 2010;35(2):232-47.
2010: Nicholas W Gilpin; George F Koob
Effects of β-adrenoceptor antagonists on alcohol drinking by alcohol-dependent rats.
Psychopharmacology 2010;212(3):431-9.
2010: Joseph Shurman; George F Koob; Howard B Gutstein
Opioids, pain, the brain, and hyperkatifeia: a framework for the rational use of opioids for pain.
Pain medicine (Malden, Mass.) 2010;11(7):1092-8.
2010: Laura Orio; Sunmee Wee; Amy H Newman; Luigi Pulvirenti; George F Koob
The dopamine D3 receptor partial agonist CJB090 and antagonist PG01037 decrease progressive ratio responding for methamphetamine in rats with extended-access.
Addiction biology 2010;15(3):312-23.
2010: olivier george; Taryn E Grieder; Maury Cole; George F Koob
Exposure to chronic intermittent nicotine vapor induces nicotine dependence.
Pharmacology, biochemistry, and behavior 2010;96(1):104-7.
2010: Sunmee Wee; George F Koob
The role of the dynorphin-kappa opioid system in the reinforcing effects of drugs of abuse.
Psychopharmacology 2010;210(2):121-35.
2010: Eric P Zorrilla; George F Koob
Progress in corticotropin-releasing factor-1 antagonist development.
Drug discovery today 2010;15(9-10):371-83.
2010: Marisa Roberto; Maureen T Cruz; Nicholas W Gilpin; Valentina Sabino; Paul Schweitzer; Michal Bajo; Pietro Cottone; Samuel G Madamba; David G Stouffer; Eric P Zorrilla; George F Koob; George R Siggins; Loren H Parsons
Corticotropin releasing factor-induced amygdala gamma-aminobutyric Acid release plays a key role in alcohol dependence.
Biological psychiatry 2010;67(9):831-9.
2010: Amira Y Moreno; Marc R Azar; Noelle A Warren; Tobin J Dickerson; George F Koob; Kim D Janda
A critical evaluation of a nicotine vaccine within a self-administration behavioral model.
Molecular pharmaceutics 2010;7(2):431-41.
2010: George F Koob
The role of CRF and CRF-related peptides in the dark side of addiction.
Brain research 2010;1314():3-14.
2010: George F Koob
Focus on: neuroscience and treatment: the potential of neuroscience to inform treatment.
Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism 2010;33(1):144-51.
2010: George F Koob; Eric P Zorrilla
Neurobiological mechanisms of addiction: focus on corticotropin-releasing factor.
Current opinion in investigational drugs (London, England : 2000) 2010;11(1):63-71.
2010: George F Koob; Nora D Volkow
Neurocircuitry of addiction.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2010;35(1):217-38.
2009: Nicholas W Gilpin; Amanda D Smith; Maury Cole; Friedbert Weiss; George F Koob; Heather N Richardson
Operant behavior and alcohol levels in blood and brain of alcohol-dependent rats.
Alcoholism, clinical and experimental research 2009;33(12):2113-23.
2009: Pietro Cottone; Valentina Sabino; Marisa Roberto; Michal Bajo; Lara Pockros; Jennifer B Frihauf; Eva Fekete; Luca Steardo; Kenner C Rice; Dimitri E Grigoriadis; Bruno Conti; George F Koob; Eric P Zorrilla
CRF system recruitment mediates dark side of compulsive eating.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(47):20016-20.
2009: Walter Francesconi; Fulvia Berton; George F Koob; Pietro Paolo Sanna
Intrinsic neuronal plasticity in the juxtacapsular nucleus of the bed nuclei of the stria terminalis (jcBNST).
Progress in neuro-psychopharmacology & biological psychiatry 2009;33(8):1347-55.
2009: Marisa Roberto; George F Koob
First Congress of "Alcoholism and stress: a framework for future treatment strategies": Introduction to the proceeding.
Alcohol (Fayetteville, N.Y.) 2009;43(7):489-90.
2009: George F Koob
Brain stress systems in the amygdala and addiction.
Brain research 2009;1293():61-75.
2009: Heather N Richardson; Stephanie H Chan; Elena F Crawford; Youn Kyung Lee; Cindy K Funk; George F Koob; Chitra D Mandyam
Permanent impairment of birth and survival of cortical and hippocampal proliferating cells following excessive drinking during alcohol dependence.
Neurobiology of disease 2009;36(1):1-10.
2009: Sunmee Wee; Laura Orio; Senait Ghirmai; John R Cashman; George F Koob
Inhibition of kappa opioid receptors attenuated increased cocaine intake in rats with extended access to cocaine.
Psychopharmacology 2009;205(4):565-75.
2009: Valentina Sabino; Pietro Cottone; Yu Zhao; Luca Steardo; George F Koob; Eric P Zorrilla
Selective reduction of alcohol drinking in Sardinian alcohol-preferring rats by a sigma-1 receptor antagonist.
Psychopharmacology 2009;205(2):327-35.
2009: George F Koob; G Kenneth Lloyd; Barbara J Mason
Development of pharmacotherapies for drug addiction: a Rosetta stone approach.
Nature reviews. Drug discovery 2009;8(6):500-15.
2009: George F Koob
Dynamics of neuronal circuits in addiction: reward, antireward, and emotional memory.
Pharmacopsychiatry 2009;42 Suppl 1():S32-41.
2009: Valentina Sabino; Pietro Cottone; Yu Zhao; Malliga R Iyer; Luca Steardo; Luca Steardo; Kenner C Rice; Bruno Conti; George F Koob; Eric P Zorrilla
The sigma-receptor antagonist BD-1063 decreases ethanol intake and reinforcement in animal models of excessive drinking.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2009;34(6):1482-93.
2009: Walter Francesconi; Fulvia Berton; Vez Repunte-Canonigo; Kazuki Hagihara; David Thurbon; Dusan Lekic; Sheila E Specio; Thomas N Greenwell; Scott A Chen; Kenner C Rice; Heather N Richardson; Laura E O'Dell; Eric P Zorrilla; Marisela Morales; George F Koob; Pietro Paolo Sanna
Protracted withdrawal from alcohol and drugs of abuse impairs long-term potentiation of intrinsic excitability in the juxtacapsular bed nucleus of the stria terminalis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(17):5389-401.
2009: Laura Orio; Scott Edwards; olivier george; Loren H Parsons; George F Koob
A role for the endocannabinoid system in the increased motivation for cocaine in extended-access conditions.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(15):4846-57.
2009: Thomas N Greenwell; Cindy K Funk; Pietro Cottone; Heather N Richardson; Scott A Chen; Kenner C Rice; Eric P Zorrilla; George F Koob
Corticotropin-releasing factor-1 receptor antagonists decrease heroin self-administration in long- but not short-access rats.
Addiction biology 2009;14(2):130-43.
2009: George F Koob
New dimensions in human laboratory models of addiction.
Addiction biology 2009;14(1):1-8.
2009: George F Koob
Neurobiological substrates for the dark side of compulsivity in addiction.
Neuropharmacology 2009;56 Suppl 1():18-31.
2009: Thomas N Greenwell; Brendan M Walker; Pietro Cottone; Eric P Zorrilla; George F Koob
The alpha1 adrenergic receptor antagonist prazosin reduces heroin self-administration in rats with extended access to heroin administration.
Pharmacology, biochemistry, and behavior 2009;91(3):295-302.
2008: Chitra D Mandyam; Sunmee Wee; Elena F Crawford; Amelia J Eisch; Heather N Richardson; George F Koob
Varied access to intravenous methamphetamine self-administration differentially alters adult hippocampal neurogenesis.
Biological psychiatry 2008;64(11):958-65.
2008: Francesco Papaleo; Sandy Ghozland; Manuela Ingallinesi; Amanda J Roberts; George F Koob; Angelo Contarino
Disruption of the CRF(2) receptor pathway decreases the somatic expression of opiate withdrawal.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2008;33(12):2878-87.
2008: George F Koob; Michel Le Moal
Review. Neurobiological mechanisms for opponent motivational processes in addiction.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2008;363(1507):3113-23.
2008: Heather N Richardson; Soon Y Lee; Laura E O'Dell; George F Koob; Catherine Rivier
Alcohol self-administration acutely stimulates the hypothalamic-pituitary-adrenal axis, but alcohol dependence leads to a dampened neuroendocrine state.
The European journal of neuroscience 2008;28(8):1641-53.
2008: Xin Du; Martin Schwander; Eva Marie Y Moresco; Pia Viviani; Claudia Haller; Michael Hildebrand; Kwang Pak; Lisa Tarantino; Amanda Roberts; Heather Richardson; George F Koob; Hossein Najmabadi; Allen F Ryan; Richard J H Smith; Ulrich Müller; Bruce Beutler
A catechol-O-methyltransferase that is essential for auditory function in mice and humans.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(38):14609-14.
2008: Nicholas W Gilpin; Heather N Richardson; George F Koob
Effects of CRF1-receptor and opioid-receptor antagonists on dependence-induced increases in alcohol drinking by alcohol-preferring (P) rats.
Alcoholism, clinical and experimental research 2008;32(9):1535-42.
2008: Nicholas W Gilpin; Kaushik Misra; George F Koob
Neuropeptide Y in the central nucleus of the amygdala suppresses dependence-induced increases in alcohol drinking.
Pharmacology, biochemistry, and behavior 2008;90(3):475-80.
2008: N W Gilpin; Heather N Richardson; L Lumeng; George F Koob
Dependence-induced alcohol drinking by alcohol-preferring (P) rats and outbred Wistar rats.
Alcoholism, clinical and experimental research 2008;32(9):1688-96.
2008: olivier george; Chitra D Mandyam; Sunmee Wee; George F Koob
Extended access to cocaine self-administration produces long-lasting prefrontal cortex-dependent working memory impairments.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2008;33(10):2474-82.
2008: George F Koob
A role for brain stress systems in addiction.
Neuron 2008;59(1):11-34.
2008: Nicholas W Gilpin; Heather N Richardson; Maury Cole; George F Koob
Vapor inhalation of alcohol in rats.
Current protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.] 2008;Chapter 9():Unit 9.29.
2008: Brendan M Walker; George F Koob
Regarding "Dynorphin is a downstream effector of striatal BDNF regulation of ethanol intake".
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(7):2113; author reply 2113-4.
2008: George F Koob
Corticotropin-releasing factor, neuroplasticity (sensitization), and alcoholism.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(26):8809-10.
2008: Marisa Roberto; Nicholas W Gilpin; Laura E O'Dell; Maureen T Cruz; Andrew C Morse; George R Siggins; George F Koob
Cellular and behavioral interactions of gabapentin with alcohol dependence.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(22):5762-71.
2008: John H Krystal; Cameron S Carter; Daniel Geschwind; Husseini K Manji; John March; Eric J Nestler; Jon K Zubieta; Dennis S Charney; David Goldman; Raquel E Gur; Jeffrey A Lieberman; Peter Roy-Byrne; David Rubinow; Stewart A Anderson; Samuel Barondes; Karen F Berman; James Blair; David L Braff; E Sherwood Brown; Joseph Calabrese; William A Carlezon; Edwin H Cook; Richard Davidson; Michael Davis; Robert Desimone; Wayne C Drevets; Ronald S Duman; Susan M Essock; Stephen Faraone; Robert Freedman; Karl J Friston; Joel Gelernter; Barbara Geller; Michael Gill; Elizabeth Gould; Anthony A Grace; Christian Grillon; Ralitza Gueorguieva; Ahmad R Hariri; Robert B Innis; Edward G Jones; Joel E Kleinman; George F Koob; Andrew D Krystal; Ellen Leibenluft; Douglas F Levinson; Pat Levitt; David A Lewis; Israel Liberzon; Barbara K Lipska; Stephen R Marder; Athina Markou; Graeme F Mason; Christopher J McDougle; Bruce McEwen; Francis McMajon; Michael J Meaney; Herbert Y Meltzer; Kathleen Ries Merikangas; Andreas Meyer-Lindenberg; Károly Mirnics; Lisa M Monteggia; Alexander Neumeister; Charles P O'Brien; Michael J Owen; Daniel S Pine; Judy Rapoport; Scott L Rauch; Trevor W Robbins; Jerrold F Rosenbaum; David R Rosenberg; Christopher A Ross; john rush; Harold A Sackeim; Gerard Sanacora; Alan F Schatzberg; Yavin Shaham; Larry J Siever; Trey Sunderland; Laurence H Tecott; Michael E Thase; Richard D Todd; Myrna M Weissman; Rachel Yehuda; Takeo Yoshikawa; Elizabeth A Young; R McCandless
It is time to take a stand for medical research and against terrorism targeting medical scientists.
Biological psychiatry 2008;63(8):725-7.
2008: Sunmee Wee; Chitra D Mandyam; Dusan M Lekic; George F Koob
Alpha 1-noradrenergic system role in increased motivation for cocaine intake in rats with prolonged access.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2008;18(4):303-11.
2008: Brendan M Walker; Dennis D Rasmussen; Murray A Raskind; George F Koob
alpha1-noradrenergic receptor antagonism blocks dependence-induced increases in responding for ethanol.
Alcohol (Fayetteville, N.Y.) 2008;42(2):91-7.
2008: Dong Ji; Nicholas W Gilpin; Heather N Richardson; Catherine Rivier; George F Koob
Effects of naltrexone, duloxetine, and a corticotropin-releasing factor type 1 receptor antagonist on binge-like alcohol drinking in rats.
Behavioural pharmacology 2008;19(1):1-12.
2008: Heather N Richardson; Yu Zhao; Eva Fekete; Cindy K Funk; Peter Wirsching; Kim D Janda; Eric P Zorrilla; George F Koob
MPZP: a novel small molecule corticotropin-releasing factor type 1 receptor (CRF1) antagonist.
Pharmacology, biochemistry, and behavior 2008;88(4):497-510.
2008: Sheila E Specio; Sunmee Wee; Laura E O'Dell; Benjamin Boutrel; Eric P Zorrilla; George F Koob
CRF(1) receptor antagonists attenuate escalated cocaine self-administration in rats.
Psychopharmacology 2008;196(3):473-82.
2008: Brendan M Walker; George F Koob
Pharmacological evidence for a motivational role of kappa-opioid systems in ethanol dependence.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2008;33(3):643-52.
2008: George F Koob
Alcoholism, corticotropin-releasing factor, and molecular genetic allostasis.
Biological psychiatry 2008;63(2):137-8.
2008: Karine Guillem; Caroline Vouillac; George F Koob; Martine Cador; Luis Stinus
Monoamine oxidase inhibition dramatically prolongs the duration of nicotine withdrawal-induced place aversion.
Biological psychiatry 2008;63(2):158-63.
2008: George F Koob; Michel Le Moal
Addiction and the brain antireward system.
Annual review of psychology 2008;59():29-53.
2007: S Barak Caine; Morgane Thomsen; Kara I Gabriel; Jill S Berkowitz; Lisa H Gold; George F Koob; Susumu Tonegawa; Jianhua Zhang; Ming Xu
Lack of self-administration of cocaine in dopamine D1 receptor knock-out mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(48):13140-50.
2007: Zhongqi Zhang; Andrew C Morse; George F Koob; Gery Schulteis
Dose- and time-dependent expression of anxiety-like behavior in the elevated plus-maze during withdrawal from acute and repeated intermittent ethanol intoxication in rats.
Alcoholism, clinical and experimental research 2007;31(11):1811-9.
2007: olivier george; Sandy Ghozland; Marc R Azar; Pietro Cottone; Eric P Zorrilla; Loren H Parsons; Laura E O'Dell; Heather N Richardson; George F Koob
CRF-CRF1 system activation mediates withdrawal-induced increases in nicotine self-administration in nicotine-dependent rats.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(43):17198-203.
2007: Chitra D Mandyam; Sunmee Wee; Amelia J Eisch; Heather N Richardson; George F Koob
Methamphetamine self-administration and voluntary exercise have opposing effects on medial prefrontal cortex gliogenesis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(42):11442-50.
2007: Antoine Tabarin; Yolanda Diz-Chaves; D Consoli; M Monsaingeon; Tracy L Bale; M D Culler; R Datta; F Drago; Wylie W Vale; George F Koob; Eric P Zorrilla; Angelo Contarino
Role of the corticotropin-releasing factor receptor type 2 in the control of food intake in mice: a meal pattern analysis.
The European journal of neuroscience 2007;26(8):2303-14.
2007: Sunmee Wee; Zhixia Wang; William L Woolverton; Luigi Pulvirenti; George F Koob
Effect of aripiprazole, a partial dopamine D2 receptor agonist, on increased rate of methamphetamine self-administration in rats with prolonged session duration.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2007;32(10):2238-47.
2007: George F Koob; Mary Jeanne Kreek
Stress, dysregulation of drug reward pathways, and the transition to drug dependence.
The American journal of psychiatry 2007;164(8):1149-59.
2007: Markus Heilig; George F Koob
A key role for corticotropin-releasing factor in alcohol dependence.
Trends in neurosciences 2007;30(8):399-406.
2007: Jennifer Treweek; Sunmee Wee; George F Koob; Tobin J Dickerson; Kim D Janda
Self-vaccination by methamphetamine glycation products chemically links chronic drug abuse and cardiovascular disease.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(28):11580-4.
2007: Cindy K Funk; George F Koob
A CRF(2) agonist administered into the central nucleus of the amygdala decreases ethanol self-administration in ethanol-dependent rats.
Brain research 2007;1155():172-8.
2007: Annika Thorsell; Vez Repunte-Canonigo; Laura E O'Dell; Scott A Chen; Alvin R King; Dusan Lekic; George F Koob; Pietro Paolo Sanna
Viral vector-induced amygdala NPY overexpression reverses increased alcohol intake caused by repeated deprivations in Wistar rats.
Brain : a journal of neurology 2007;130(Pt 5):1330-7.
2007: Michel Le Moal; George F Koob
Drug addiction: pathways to the disease and pathophysiological perspectives.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2007;17(6-7):377-93.
2007: Eva Fekete; Koki Inoue; Yu Zhao; Jean E Rivier; Wylie W Vale; Attila Szücs; George F Koob; Eric P Zorrilla
Delayed satiety-like actions and altered feeding microstructure by a selective type 2 corticotropin-releasing factor agonist in rats: intra-hypothalamic urocortin 3 administration reduces food intake by prolonging the post-meal interval.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2007;32(5):1052-68.
2007: Kathleen Chu; George F Koob; Maury Cole; Eric P Zorrilla; Amanda J Roberts
Dependence-induced increases in ethanol self-administration in mice are blocked by the CRF1 receptor antagonist antalarmin and by CRF1 receptor knockout.
Pharmacology, biochemistry, and behavior 2007;86(4):813-21.
2007: Andrew P Brogan; Lisa M Eubanks; George F Koob; Tobin J Dickerson; Kim D Janda
Antibody-catalyzed oxidation of delta(9)-tetrahydrocannabinol.
Journal of the American Chemical Society 2007;129(12):3698-702.
2007: Sunmee Wee; Sheila E Specio; George F Koob
Effects of dose and session duration on cocaine self-administration in rats.
The Journal of pharmacology and experimental therapeutics 2007;320(3):1134-43.
2007: Laura E O'Dell; George F Koob
'Nicotine deprivation effect' in rats with intermittent 23-hour access to intravenous nicotine self-administration.
Pharmacology, biochemistry, and behavior 2007;86(2):346-53.
2007: Marylou V Solbrig; Russell Adrian; Steven L Wechsler; George F Koob
Activators of potassium M currents have anticonvulsant actions in two rat models of encephalitis.
European journal of pharmacology 2007;555(1):23-9.
2007: Brendan M Walker; George F Koob
The gamma-aminobutyric acid-B receptor agonist baclofen attenuates responding for ethanol in ethanol-dependent rats.
Alcoholism, clinical and experimental research 2007;31(1):11-8.
2007: Laura E O'Dell; Scott A Chen; Ron T Smith; Sheila E Specio; Robert L Balster; Neil E Paterson; Athina Markou; Eric P Zorrilla; George F Koob
Extended access to nicotine self-administration leads to dependence: Circadian measures, withdrawal measures, and extinction behavior in rats.
The Journal of pharmacology and experimental therapeutics 2007;320(1):180-93.
2007: Cindy K Funk; Eric P Zorrilla; Mei-Jing Lee; Kenner C Rice; George F Koob
Corticotropin-releasing factor 1 antagonists selectively reduce ethanol self-administration in ethanol-dependent rats.
Biological psychiatry 2007;61(1):78-86.
2006: Karine Guillem; Caroline Vouillac; Marc R Azar; Loren H Parsons; George F Koob; Martine Cador; Luis Stinus
Monoamine oxidase A rather than monoamine oxidase B inhibition increases nicotine reinforcement in rats.
The European journal of neuroscience 2006;24(12):3532-40.
2006: Valentina Sabino; Pietro Cottone; George F Koob; Luca Steardo; Mei J Lee; Kenner C Rice; Eric P Zorrilla
Dissociation between opioid and CRF1 antagonist sensitive drinking in Sardinian alcohol-preferring rats.
Psychopharmacology 2006;189(2):175-86.
2006: Scott A Chen; Laura E O'Dell; Michael E Hoefer; Thomas Greenwell; Eric P Zorrilla; George F Koob
Unlimited access to heroin self-administration: independent motivational markers of opiate dependence.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2006;31(12):2692-707.
2006: Charles P O'Brien; George F Koob; David Mee-Lee; Richard N Rosenthal
New developments in addiction treatment.
The Journal of clinical psychiatry 2006;67(11):1801-12.
2006: Lisa M Eubanks; Claude J Rogers; Albert E. Beuscher; George F Koob; Arthur J Olson; Tobin J Dickerson; Kim D Janda
A molecular link between the active component of marijuana and Alzheimer's disease pathology.
Molecular pharmaceutics 2006;3(6):773-7.
2006: Cindy K Funk; Laura E O'Dell; Elena F Crawford; George F Koob
Corticotropin-releasing factor within the central nucleus of the amygdala mediates enhanced ethanol self-administration in withdrawn, ethanol-dependent rats.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(44):11324-32.
2006: Scott C Steffensen; Sarah H Stobbs; Eric E O Colago; Rong-Sheng Lee; George F Koob; Roger A Gallegos; Steven J Henriksen
Contingent and non-contingent effects of heroin on mu-opioid receptor-containing ventral tegmental area GABA neurons.
Experimental neurology 2006;202(1):139-51.
2006: John C Crabbe; Tamara J Phillips; R Adron Harris; Michael A Arends; George F Koob
Alcohol-related genes: contributions from studies with genetically engineered mice.
Addiction biology 2006;11(3-4):195-269.
2006: George F Koob
The neurobiology of addiction: a neuroadaptational view relevant for diagnosis.
Addiction (Abingdon, England) 2006;101 Suppl 1():23-30.
2006: Laura E O'Dell; Adrie W Bruijnzeel; Ron T Smith; Loren H Parsons; Michele L Merves; Bruce A Goldberger; Heather N Richardson; George F Koob; Athina Markou
Diminished nicotine withdrawal in adolescent rats: implications for vulnerability to addiction.
Psychopharmacology 2006;186(4):612-9.
2006: Paul J Kenny; Scott A Chen; Osamu Kitamura; Athina Markou; George F Koob
Conditioned withdrawal drives heroin consumption and decreases reward sensitivity.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(22):5894-900.
2006: Osamu Kitamura; Sunmee Wee; Sheila E Specio; George F Koob; Luigi Pulvirenti
Escalation of methamphetamine self-administration in rats: a dose-effect function.
Psychopharmacology 2006;186(1):48-53.
2006: Megan K Mulligan; Igor Ponomarev; Robert Hitzemann; John K Belknap; Boris Tabakoff; R Adron Harris; John C Crabbe; Yuri A Blednov; Nicholas J Grahame; Tamara J Phillips; Deborah A Finn; Paula L Hoffman; Vishwanath R Iyer; George F Koob; Susan E Bergeson
Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(16):6368-73.
2006: Michael E Hoefer; Steven J Voskanian; George F Koob; Luigi Pulvirenti
Effects of terguride, ropinirole, and acetyl-L-carnitine on methamphetamine withdrawal in the rat.
Pharmacology, biochemistry, and behavior 2006;83(3):403-9.
2006: Bankole A Johnson; George F Koob; Marc A Schuckit; Barbara J Mason; Nassima Ait-Daoud
Understanding and treating alcohol dependence.
Alcoholism, clinical and experimental research 2006;30(3):567-84.
2006: Marylou V Solbrig; Russell Adrian; Janie Baratta; Julie C Lauterborn; George F Koob
Kappa opioid control of seizures produced by a virus in an animal model.
Brain : a journal of neurology 2006;129(Pt 3):642-54.
2006: Stephen C Heinrichs; George F Koob
Application of experimental stressors in laboratory rodents.
Current protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.] 2006;Chapter 8():Unit8.4.
2006: Henry R Kranzler; George F Koob; David Gastfriend; Robert Swift; Mark L Willenbring
Advances in the pharmacotherapy of alcoholism: challenging misconceptions.
Alcoholism, clinical and experimental research 2006;30(2):272-81.
2006: George F Koob
A role for GABA in alcohol dependence.
Advances in pharmacology (San Diego, Calif.) 2006;54():205-29.
2005: Benjamin Boutrel; Paul J Kenny; Sheila E Specio; Rémi Martin-Fardon; Athina Markou; George F Koob; Luis de Lecea
Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(52):19168-73.
2005: Antoine Tabarin; Yolanda Diz-Chaves; Yolanda Diz Chaves; Maria del Carmen Carmona; Bogdan Catargi; Eric P Zorrilla; Amanda J Roberts; Donald V Coscina; Sophie Rousset; Anabelle Redonnet; Graham C Parker; Koki Inoue; Daniel Ricquier; Luc Pénicaud; Jerome Becker; George F Koob
Resistance to diet-induced obesity in mu-opioid receptor-deficient mice: evidence for a "thrifty gene".
Diabetes 2005;54(12):3510-6.
2005: Longwu Qi; Noboru Yamamoto; Michael M Meijler; Laurence Altobell; George F Koob; Peter Wirsching; Kim D Janda
Delta9-tetrahydrocannabinol immunochemical studies: haptens, monoclonal antibodies, and a convenient synthesis of radiolabeled delta9-tetrahydrocannabinol.
Journal of medicinal chemistry 2005;48(23):7389-99.
2005: George F Koob; Michel Le Moal
Plasticity of reward neurocircuitry and the 'dark side' of drug addiction.
Nature neuroscience 2005;8(11):1442-4.
2005: Karine Guillem; Caroline Vouillac; Marc R Azar; Loren H Parsons; George F Koob; Martine Cador; Luis Stinus
Monoamine oxidase inhibition dramatically increases the motivation to self-administer nicotine in rats.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(38):8593-600.
2005: Serge H Ahmed; Robert Lutjens; Lena D van der Stap; Dusan Lekic; vincenzo romano spica; Marisela Morales; George F Koob; Vez Repunte-Canonigo; Pietro Paolo Sanna
Gene expression evidence for remodeling of lateral hypothalamic circuitry in cocaine addiction.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(32):11533-8.
2005: CARLA SANCHIS-SEGURA; Judy E Grisel; M Foster Olive; Sandy Ghozland; George F Koob; Amanda J Roberts; Michael S Cowen
Role of the endogenous opioid system on the neuropsychopharmacological effects of ethanol: new insights about an old question.
Alcoholism, clinical and experimental research 2005;29(8):1522-7.
2005: Emanuela Izzo; Pietro Paolo Sanna; George F Koob
Impairment of dopaminergic system function after chronic treatment with corticotropin-releasing factor.
Pharmacology, biochemistry, and behavior 2005;81(4):701-8.
2005: Laura E O'Dell; Robert H Purdy; D F Covey; Heather N Richardson; Marisa Roberto; George F Koob
Epipregnanolone and a novel synthetic neuroactive steroid reduce alcohol self-administration in rats.
Pharmacology, biochemistry, and behavior 2005;81(3):543-50.
2005: Serge H Ahmed; George F Koob
Transition to drug addiction: a negative reinforcement model based on an allostatic decrease in reward function.
Psychopharmacology 2005;180(3):473-90.
2005: Eric P Zorrilla; Koki Inoue; Eva Fekete; Antoine Tabarin; Glenn R Valdez; George F Koob
Measuring meals: structure of prandial food and water intake of rats.
American journal of physiology. Regulatory, integrative and comparative physiology 2005;288(6):R1450-67.
2005: Paul J Kenny; Benjamin Boutrel; Fabrizio Gasparini; George F Koob; Athina Markou
Metabotropic glutamate 5 receptor blockade may attenuate cocaine self-administration by decreasing brain reward function in rats.
Psychopharmacology 2005;179(1):247-54.
2005: George R Breese; Kathleen Chu; Christopher V Dayas; Douglas Funk; Darin J Knapp; George F Koob; Dzung Anh Lê; Laura E O'Dell; David H Overstreet; Amanda J Roberts; Rajita Sinha; Glenn R Valdez; Friedbert Weiss
Stress enhancement of craving during sobriety: a risk for relapse.
Alcoholism, clinical and experimental research 2005;29(2):185-95.
2005: Philippe De Witte; John Littleton; Philippe Parot; George F Koob
Neuroprotective and abstinence-promoting effects of acamprosate: elucidating the mechanism of action.
CNS drugs 2005;19(6):517-37.
2005: Eric P Zorrilla; Koki Inoue; Glenn R Valdez; Antoine Tabarin; George F Koob
Leptin and post-prandial satiety: acute central leptin more potently reduces meal frequency than meal size in the rat.
Psychopharmacology 2005;177(3):324-35.
2005: Luis Stinus; Martine Cador; Eric P Zorrilla; George F Koob
Buprenorphine and a CRF1 antagonist block the acquisition of opiate withdrawal-induced conditioned place aversion in rats.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2005;30(1):90-8.
2004: Glenn R Valdez; George F Koob
Allostasis and dysregulation of corticotropin-releasing factor and neuropeptide Y systems: implications for the development of alcoholism.
Pharmacology, biochemistry, and behavior 2004;79(4):671-89.
2004: Laura E O'Dell; Amanda J Roberts; Ron T Smith; George F Koob
Enhanced alcohol self-administration after intermittent versus continuous alcohol vapor exposure.
Alcoholism, clinical and experimental research 2004;28(11):1676-82.
2004: Stephen C Heinrichs; George F Koob
Corticotropin-releasing factor in brain: a role in activation, arousal, and affect regulation.
The Journal of pharmacology and experimental therapeutics 2004;311(2):427-40.
2004: George F Koob
A role for GABA mechanisms in the motivational effects of alcohol.
Biochemical pharmacology 2004;68(8):1515-25.
2004: Miguel Navarro; M Rocío A Carrera; Ignacio Del Arco; Jose Manuel Trigo; George F Koob; Fernando Rodríguez de Fonseca
Cannabinoid receptor antagonist reduces heroin self-administration only in dependent rats.
European journal of pharmacology 2004;501(1-3):235-7.
2004: Gilles Martin; Ana Guadaño-Ferraz; Beatriz Morte; Serge Ahmed; George F Koob; Luis de Lecea; George R Siggins
Chronic morphine treatment alters N-methyl-D-aspartate receptors in freshly isolated neurons from nucleus accumbens.
The Journal of pharmacology and experimental therapeutics 2004;311(1):265-73.
2004: Benjamin Boutrel; George F Koob
What keeps us awake: the neuropharmacology of stimulants and wakefulness-promoting medications.
Sleep 2004;27(6):1181-94.
2004: Eric P Zorrilla; Lindsay E Reinhardt; Glenn R Valdez; Koki Inoue; Jean E Rivier; Wylie W Vale; George F Koob
Human urocortin 2, a corticotropin-releasing factor (CRF)2 agonist, and ovine CRF, a CRF1 agonist, differentially alter feeding and motor activity.
The Journal of pharmacology and experimental therapeutics 2004;310(3):1027-34.
2004: George F Koob; Thomas Greenwell
Neuropeptide S: a novel activating anxiolytic?
Neuron 2004;43(4):441-2.
2004: M Rocío A Carrera; Gunnar Kaufmann; Jenny M Mee; Michael M Meijler; George F Koob; Kim D Janda
Treating cocaine addiction with viruses.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(28):10416-21.
2004: Eric P Zorrilla; George F Koob
The therapeutic potential of CRF1 antagonists for anxiety.
Expert opinion on investigational drugs 2004;13(7):799-828.
2004: Laura E O'Dell; Adrie W Bruijnzeel; Sandy Ghozland; Athina Markou; George F Koob
Nicotine withdrawal in adolescent and adult rats.
Annals of the New York Academy of Sciences 2004;1021():167-74.
2004: Glenn R Valdez; Valentina Sabino; George F Koob
Increased anxiety-like behavior and ethanol self-administration in dependent rats: reversal via corticotropin-releasing factor-2 receptor activation.
Alcoholism, clinical and experimental research 2004;28(6):865-72.
2004: Koki Inoue; Eric P Zorrilla; Antoine Tabarin; Glenn R Valdez; Sinichi Iwasaki; Nobuo Kiriike; George F Koob
Reduction of anxiety after restricted feeding in the rat: implication for eating disorders.
Biological psychiatry 2004;55(11):1075-81.
2004: Marc R Azar; Serge H Ahmed; R Lintz; Tannia Gutierrez; Luis Stinus; George F Koob
A non-invasive gating device for continuous drug delivery that allows control over the timing and duration of spontaneous opiate withdrawal.
Journal of neuroscience methods 2004;135(1-2):129-35.
2004: Pietro Paolo Sanna; George F Koob
Cocaine's long run.
Nature medicine 2004;10(4):340-1.
2004: Serge H Ahmed; George F Koob
Changes in response to a dopamine receptor antagonist in rats with escalating cocaine intake.
Psychopharmacology 2004;172(4):450-4.
2004: Marylou V Solbrig; George F Koob
Epilepsy, CNS viral injury and dynorphin.
Trends in pharmacological sciences 2004;25(2):98-104.
2004: M Rocío A Carrera; Jon A Ashley; Timothy Z Hoffman; Shigeki Isomura; Peter Wirsching; George F Koob; Kim D Janda
Investigations using immunization to attenuate the psychoactive effects of nicotine.
Bioorganic & medicinal chemistry 2004;12(3):563-70.
2004: Laura E O'Dell; Ahmed A Alomary; Monique Vallée; George F Koob; Robert L Fitzgerald; Robert H Purdy
Ethanol-induced increases in neuroactive steroids in the rat brain and plasma are absent in adrenalectomized and gonadectomized rats.
European journal of pharmacology 2004;484(2-3):241-7.
2004: Osnat Ben-Shahar; Serge H Ahmed; George F Koob; Aaron Ettenberg
The transition from controlled to compulsive drug use is associated with a loss of sensitization.
Brain research 2004;995(1):46-54.
2004: George F Koob
Allostatic view of motivation: implications for psychopathology.
Nebraska Symposium on Motivation. Nebraska Symposium on Motivation 2004;50():1-18.
2004: George F Koob; Serge H Ahmed; Benjamin Boutrel; Scott A Chen; Paul J Kenny; Athina Markou; Laura E O'Dell; Loren H Parsons; Pietro Paolo Sanna
Neurobiological mechanisms in the transition from drug use to drug dependence.
Neuroscience and biobehavioral reviews 2004;27(8):739-49.
2004: Michael Weed; Lisa H Gold; Ilham Polis; George F Koob; Howard S Fox; Michael Taffe
Impaired performance on a rhesus monkey neuropsychological testing battery following simian immunodeficiency virus infection.
AIDS research and human retroviruses 2004;20(1):77-89.
2003: George F Koob
Neuroadaptive mechanisms of addiction: studies on the extended amygdala.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2003;13(6):442-52.
2003: Paul J Kenny; Neil E Paterson; Benjamin Boutrel; Svetlana Semenova; Amanda A Harrison; Fabrizio Gasparini; George F Koob; P D Skoubis; Athina Markou
Metabotropic glutamate 5 receptor antagonist MPEP decreased nicotine and cocaine self-administration but not nicotine and cocaine-induced facilitation of brain reward function in rats.
Annals of the New York Academy of Sciences 2003;1003():415-8.
2003: Paul J Kenny; George F Koob; Athina Markou
Conditioned facilitation of brain reward function after repeated cocaine administration.
Behavioral neuroscience 2003;117(5):1103-7.
2003: Glenn R Valdez; Eric P Zorrilla; Jean Rivier; Wylie W Vale; George F Koob
Locomotor suppressive and anxiolytic-like effects of urocortin 3, a highly selective type 2 corticotropin-releasing factor agonist.
Brain research 2003;980(2):206-12.
2003: Eric P Zorrilla; Yvette Taché; George F Koob
Nibbling at CRF receptor control of feeding and gastrocolonic motility.
Trends in pharmacological sciences 2003;24(8):421-7.
2003: Charles J Heyser; Kelly Moc; George F Koob
Effects of naltrexone alone and in combination with acamprosate on the alcohol deprivation effect in rats.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2003;28(8):1463-71.
2003: Serge H Ahmed; Daniel Lin; George F Koob; Loren H Parsons
Escalation of cocaine self-administration does not depend on altered cocaine-induced nucleus accumbens dopamine levels.
Journal of neurochemistry 2003;86(1):102-13.
2003: Monique Vallée; Robert H Purdy; Willy Mayo; George F Koob; Michel Le Moal
Neuroactive steroids: new biomarkers of cognitive aging.
The Journal of steroid biochemistry and molecular biology 2003;85(2-5):329-35.
2003: John R Walker; Scott A Chen; Heather Moffitt; Charles E Inturrisi; George F Koob
Chronic opioid exposure produces increased heroin self-administration in rats.
Pharmacology, biochemistry, and behavior 2003;75(2):349-54.
2003: Koki Inoue; Glenn R Valdez; Teresa Reyes; Lindsay E Reinhardt; Antoine Tabarin; Jean Rivier; Wylie W Vale; Paul E Sawchenko; George F Koob; Eric P Zorrilla
Human urocortin II, a selective agonist for the type 2 corticotropin-releasing factor receptor, decreases feeding and drinking in the rat.
The Journal of pharmacology and experimental therapeutics 2003;305(1):385-93.
2003: Marylou V Solbrig; George F Koob
Neuropharmacological sequelae of persistent CNS viral infections: lessons from Borna disease virus.
Pharmacology, biochemistry, and behavior 2003;74(4):777-87.
2003: Glenn R Valdez; Eric P Zorrilla; Amanda J Roberts; George F Koob
Antagonism of corticotropin-releasing factor attenuates the enhanced responsiveness to stress observed during protracted ethanol abstinence.
Alcohol (Fayetteville, N.Y.) 2003;29(2):55-60.
2003: George F Koob
Alcoholism: allostasis and beyond.
Alcoholism, clinical and experimental research 2003;27(2):232-43.
2003: Stéphanie Caillé; Luis Stinus; Emilio F Espejo; Philippe De Deurwaerdère; Umberto Spampinato; George F Koob
Inhibition of 5-HT neurotransmission increases clonidine protective effects on naloxone-induced conditioned place aversion in morphine-dependent rats.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2003;28(2):276-83.
2003: George F Koob; Amanda J Roberts; Jerome Becker; Charles J Heyser; Simon N Katner; Roberto Ciccocioppo; Friedbert Weiss
Animal models of motivation for drinking in rodents with a focus on opioid receptor neuropharmacology.
Recent developments in alcoholism : an official publication of the American Medical Society on Alcoholism, the Research Society on Alcoholism, and the National Council on Alcoholism 2003;16():263-81.
2003: Ahmed A Alomary; Monique Vallée; Laura E O'Dell; George F Koob; Robert H Purdy; Robert L Fitzgerald
Acutely administered ethanol participates in testosterone synthesis and increases testosterone in rat brain.
Alcoholism, clinical and experimental research 2003;27(1):38-43.
2003: Paul J Kenny; Ilham Polis; George F Koob; Athina Markou
Low dose cocaine self-administration transiently increases but high dose cocaine persistently decreases brain reward function in rats.
The European journal of neuroscience 2003;17(1):191-5.
2002: Emanuela Izzo; Rémi Martin-Fardon; George F Koob; Friedbert Weiss; Pietro Paolo Sanna
Neural plasticity and addiction: PI3-kinase and cocaine behavioral sensitization.
Nature neuroscience 2002;5(12):1263-4.
2002: Marylou V Solbrig; George F Koob; W Ian Lipkin
Key role for enkephalinergic tone in cortico-striatal-thalamic function.
The European journal of neuroscience 2002;16(9):1819-22.
2002: Eric P Zorrilla; Gery Schulteis; Amanda Ormsby; Alwin Klaassen; Nicholas Ling; James R McCarthy; George F Koob; Errol B De Souza
Urocortin shares the memory modulating effects of corticotropin-releasing factor (CRF): mediation by CRF1 receptors.
Brain research 2002;952(2):200-10.
2002: Eric P Zorrilla; Glenn R Valdez; Joachim Nozulak; George F Koob; Athina Markou
Effects of antalarmin, a CRF type 1 receptor antagonist, on anxiety-like behavior and motor activation in the rat.
Brain research 2002;952(2):188-99.
2002: Glenn R Valdez; Amanda J Roberts; Karen Chan; Heather Davis; Molly Brennan; Eric P Zorrilla; George F Koob
Increased ethanol self-administration and anxiety-like behavior during acute ethanol withdrawal and protracted abstinence: regulation by corticotropin-releasing factor.
Alcoholism, clinical and experimental research 2002;26(10):1494-501.
2002: Pietro Paolo Sanna; Cindy Simpson; Robert Lutjens; George F Koob
ERK regulation in chronic ethanol exposure and withdrawal.
Brain research 2002;948(1-2):186-91.
2002: John R Walker; Lars Terenius; George F Koob
Conditioned opioid withdrawal decreases nociceptin/orphanin FQ levels in the frontal cortex and olfactory tubercle.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2002;27(2):203-11.
2002: Douglas Vetter; Chien Li; Lingyun Zhao; Angelo Contarino; M Charles Liberman; George W Smith; Yelena Marchuk; George F Koob; Stephen F Heinemann; Wylie Vale; Kuo-Fen Lee
Urocortin-deficient mice show hearing impairment and increased anxiety-like behavior.
Nature genetics 2002;31(4):363-9.
2002: Glenn R Valdez; Koki Inoue; George F Koob; Jean Rivier; Wylie Vale; Eric P Zorrilla
Human urocortin II: mild locomotor suppressive and delayed anxiolytic-like effects of a novel corticotropin-releasing factor related peptide.
Brain research 2002;943(1):142-50.
2002: Stéphanie Caillé; Emilio F Espejo; George F Koob; Luis Stinus
Dorsal and median raphe serotonergic system lesion does not alter the opiate withdrawal syndrome.
Pharmacology, biochemistry, and behavior 2002;72(4):979-86.
2002: Serge H Ahmed; Paul J Kenny; George F Koob; Athina Markou
Neurobiological evidence for hedonic allostasis associated with escalating cocaine use.
Nature neuroscience 2002;5(7):625-6.
2002: Angelo Contarino; Roberto Picetti; Hans W Matthes; George F Koob; Jerome Becker; Lisa H Gold
Lack of reward and locomotor stimulation induced by heroin in mu-opioid receptor-deficient mice.
European journal of pharmacology 2002;446(1-3):103-9.
2002: Amanda D Smith; M Amalric; George F Koob; Michael Zigmond
Effect of bilateral 6-hydroxydopamine lesions of the medial forebrain bundle on reaction time.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2002;26(6):756-64.
2002: Andrey E Ryabinin; Ryan K Bachtell; Stephen C Heinrichs; Soon Lee; Catherine Rivier; M Foster Olive; Kristin K Mehmert; Rosana Camarini; Joseph A Kim; Heather N Koenig; Michelle A Nannini; Clyde W Hodge; Amanda J Roberts; George F Koob
The corticotropin-releasing factor/urocortin system and alcohol.
Alcoholism, clinical and experimental research 2002;26(5):714-22.
2002: George F Koob; Barbara J Mason; Philippe De Witte; John Littleton; George R Siggins
Potential neuroprotective effects of acamprosate.
Alcoholism, clinical and experimental research 2002;26(4):586-92.
2002: Basalingappa L Hungund; Balapal S Basavarajappa; Csaba Vadasz; George Kunos; Fernando Rodriguez de Fonseca; Giancarlo Colombo; Salvatore Serra; Loren Parsons; George F Koob
Ethanol, endocannabinoids, and the cannabinoidergic signaling system.
Alcoholism, clinical and experimental research 2002;26(4):565-74.
2002: Luigi Pulvirenti; George F Koob
Being partial to psychostimulant addiction therapy.
Trends in pharmacological sciences 2002;23(4):151-3.
2002: MG Spina; E Merlo-Pich; Yvette Akwa; C Balducci; AM Basso; Eric P Zorrilla; KT Britton; J Rivier; W W Vale; George F Koob
Time-dependent induction of anxiogenic-like effects after central infusion of urocortin or corticotropin-releasing factor in the rat.
Psychopharmacology 2002;160(2):113-21.
2002: Cristina Orsini; Emanuela Izzo; George F Koob; Luigi Pulvirenti
Blockade of nitric oxide synthesis reduces responding for cocaine self-administration during extinction and reinstatement.
Brain research 2002;925(2):133-40.
2002: Tracy L Bale; Roberto Picetti; Angelo Contarino; George F Koob; Wylie W Vale; Kuo-Fen Lee
Mice deficient for both corticotropin-releasing factor receptor 1 (CRFR1) and CRFR2 have an impaired stress response and display sexually dichotomous anxiety-like behavior.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(1):193-9.
2001: Monique Vallée; W Shen; S C Heinrichs; C F Zorumski; D F Covey; George F Koob; Robert H Purdy
Steroid structure and pharmacological properties determine the anti-amnesic effects of pregnenolone sulphate in the passive avoidance task in rats.
The European journal of neuroscience 2001;14(12):2003-10.
2001: Cristina Orsini; George F Koob; Luigi Pulvirenti
Dopamine partial agonist reverses amphetamine withdrawal in rats.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2001;25(5):789-92.
2001: Paul J Currie; Donald V Coscina; Christopher Bishop; C D Coiro; George F Koob; J Rivier; W Vale
Hypothalamic paraventricular nucleus injections of urocortin alter food intake and respiratory quotient.
Brain research 2001;916(1-2):222-8.
2001: Amanda J Roberts; Lisa H Gold; Ilham Polis; JS McDonald; Dominique Filliol; Jerome Becker; George F Koob
Increased ethanol self-administration in delta-opioid receptor knockout mice.
Alcoholism, clinical and experimental research 2001;25(9):1249-56.
2001: Miguel Navarro; M Rocío A Carrera; Walter Fratta; O Valverde; Gregorio Cossu; Liana Fattore; Julie A Chowen; R Gomez; Ignacio Del Arco; MA Villanua; Rafael Maldonado; George F Koob; F Rodriguez de Fonseca
Functional interaction between opioid and cannabinoid receptors in drug self-administration.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(14):5344-50.
2001: E P Zorrilla; Gery Schulteis; Nicholas Ling; George F Koob; Errol B De Souza
Performance-enhancing effects of CRF-BP ligand inhibitors.
Neuroreport 2001;12(6):1231-4.
2001: Anh Dzung Lê; Kalervo Kiianmaa; Christopher L Cunningham; Jörgen A Engel; M Ericson; Bo Söderpalm; George F Koob; Amanda J Roberts; F Weiss; Petri Hyytiä; Sanna Janhunen; Janne A V Mikkola; Pia Bäckström; I Ponomarev; John C Crabbe
Neurobiological processes in alcohol addiction.
Alcoholism, clinical and experimental research 2001;25(5 Suppl ISBRA):144S-151S.
2001: Emanuela Izzo; Cristina Orsini; George F Koob; Luigi Pulvirenti
A dopamine partial agonist and antagonist block amphetamine self-administration in a progressive ratio schedule.
Pharmacology, biochemistry, and behavior 2001;68(4):701-8.
2001: D J Macey; Wolfgang Froestl; George F Koob; Athina Markou
Both GABA(B) receptor agonist and antagonists decreased brain stimulation reward in the rat.
Neuropharmacology 2001;40(5):676-85.
2001: V David; Lisa H Gold; George F Koob; P Cazala
Anxiogenic-like effects limit rewarding effects of cocaine in balb/cbyj mice.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2001;24(3):300-18.
2001: M Rocío A Carrera; Jon A Ashley; Peter Wirsching; George F Koob; Kim D Janda
A second-generation vaccine protects against the psychoactive effects of cocaine.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(4):1988-92.
2001: KN Gracy; L A Dankiewicz; George F Koob
Opiate withdrawal-induced fos immunoreactivity in the rat extended amygdala parallels the development of conditioned place aversion.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2001;24(2):152-60.
2001: George F Koob; Michel Le Moal
Drug addiction, dysregulation of reward, and allostasis.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2001;24(2):97-129.
2001: F Weiss; George F Koob
Drug addiction: functional neurotoxicity of the brain reward systems.
Neurotoxicity research 2001;3(1):145-56.
2001: Monique Vallée; Willy Mayo; George F Koob; Michel Le Moal
Neurosteroids in learning and memory processes.
International review of neurobiology 2001;46():273-320.
2000: R M Richter; Eric P Zorrilla; AM Basso; George F Koob; F Weiss
Altered amygdalar CRF release and increased anxiety-like behavior in Sardinian alcohol-preferring rats: a microdialysis and behavioral study.
Alcoholism, clinical and experimental research 2000;24(12):1765-72.
2000: Monique Vallée; J D Rivera; George F Koob; Robert H Purdy; Robert L Fitzgerald
Quantification of neurosteroids in rat plasma and brain following swim stress and allopregnanolone administration using negative chemical ionization gas chromatography/mass spectrometry.
Analytical biochemistry 2000;287(1):153-66.
2000: Marylou V Solbrig; George F Koob; L H Parsons; T Kadota; Nigel Horscroft; Thomas Briese; W Ian Lipkin
Neurotrophic factor expression after CNS viral injury produces enhanced sensitivity to psychostimulants: potential mechanism for addiction vulnerability.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(21):RC104.
2000: George F Koob
Drug addiction.
Neurobiology of disease 2000;7(5):543-5.
2000: A C Morse; Gery Schulteis; F A Holloway; George F Koob
Conditioned place aversion to the "hangover" phase of acute ethanol administration in the rat.
Alcohol (Fayetteville, N.Y.) 2000;22(1):19-24.
2000: George F Koob
Animal models of craving for ethanol.
Addiction (Abingdon, England) 2000;95 Suppl 2():S73-81.
2000: Angelo Contarino; F Dellu; George F Koob; George W Smith; Kuo-Fen Lee; Wylie W Vale; Lisa H Gold
Dissociation of locomotor activation and suppression of food intake induced by CRF in CRFR1-deficient mice.
Endocrinology 2000;141(7):2698-702.
2000: Gery Schulteis; S H Ahmed; Andrew C Morse; George F Koob; Barry J Everitt
Conditioning and opiate withdrawal.
Nature 2000;405(6790):1013-4.
2000: D J Macey; George F Koob; Athina Markou
CRF and urocortin decreased brain stimulation reward in the rat: reversal by a CRF receptor antagonist.
Brain research 2000;866(1-2):82-91.
2000: Amanda J Roberts; JS McDonald; Charles J Heyser; Jerome Becker; H W Matthes; George F Koob; Lisa H Gold
mu-Opioid receptor knockout mice do not self-administer alcohol.
The Journal of pharmacology and experimental therapeutics 2000;293(3):1002-8.
2000: Amanda J Roberts; Charles J Heyser; Maury Cole; P Griffin; George F Koob
Excessive ethanol drinking following a history of dependence: animal model of allostasis.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2000;22(6):581-94.
2000: M Rocío A Carrera; Jon A Ashley; Bin Zhou; Peter Wirsching; George F Koob; Kim D Janda
Cocaine vaccines: antibody protection against relapse in a rat model.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(11):6202-6.
2000: Luis Stinus; S Caille; George F Koob
Opiate withdrawal-induced place aversion lasts for up to 16 weeks.
Psychopharmacology 2000;149(2):115-20.
2000: Tracy L Bale; Angelo Contarino; George W Smith; R Chan; Lisa H Gold; Paul E Sawchenko; George F Koob; Wylie W Vale; Kuo-Fen Lee
Mice deficient for corticotropin-releasing hormone receptor-2 display anxiety-like behaviour and are hypersensitive to stress.
Nature genetics 2000;24(4):410-4.
2000: Serge H Ahmed; John R Walker; George F Koob
Persistent increase in the motivation to take heroin in rats with a history of drug escalation.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2000;22(4):413-21.
2000: A D Smith; D L Smith; Michael Zigmond; M Amalric; George F Koob
Differential effects of dopamine receptor subtype blockade on performance of rats in a reaction-time paradigm.
Psychopharmacology 2000;148(4):355-60.
2000: MG Spina; AM Basso; Eric P Zorrilla; Charles J Heyser; J Rivier; W Vale; E Merlo-Pich; George F Koob
Behavioral effects of central administration of the novel CRF antagonist astressin in rats.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2000;22(3):230-9.
2000: SS Watkins; Luis Stinus; George F Koob; Athina Markou
Reward and somatic changes during precipitated nicotine withdrawal in rats: centrally and peripherally mediated effects.
The Journal of pharmacology and experimental therapeutics 2000;292(3):1053-64.
2000: KN Gracy; L A Dankiewicz; Friedbert Weiss; George F Koob
Heroin-specific stimuli reinstate operant heroin-seeking behavior in rats after prolonged extinction.
Pharmacology, biochemistry, and behavior 2000;65(3):489-94.
2000: Daniel Lin; George F Koob; Athina Markou
Time-dependent alterations in ICSS thresholds associated with repeated amphetamine administrations.
Pharmacology, biochemistry, and behavior 2000;65(3):407-17.
2000: SS Watkins; George F Koob; Athina Markou
Neural mechanisms underlying nicotine addiction: acute positive reinforcement and withdrawal.
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 2000;2(1):19-37.
2000: John R Walker; Serge H Ahmed; KN Gracy; George F Koob
Microinjections of an opiate receptor antagonist into the bed nucleus of the stria terminalis suppress heroin self-administration in dependent rats.
Brain research 2000;854(1-2):85-92.
2000: George F Koob
Neurobiology of addiction. Toward the development of new therapies.
Annals of the New York Academy of Sciences 2000;909():170-85.
2000: KT Britton; Yvette Akwa; M G Spina; George F Koob
Neuropeptide Y blocks anxiogenic-like behavioral action of corticotropin-releasing factor in an operant conflict test and elevated plus maze.
Peptides 2000;21(1):37-44.
2000: F Dellu; Angelo Contarino; Hervé Simon; George F Koob; Lisa H Gold
Genetic differences in response to novelty and spatial memory using a two-trial recognition task in mice.
Neurobiology of learning and memory 2000;73(1):31-48.
1999: BA Baldo; George F Koob; Athina Markou
Role of adenosine A2 receptors in brain stimulation reward under baseline conditions and during cocaine withdrawal in rats.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(24):11017-26.
1999: Fernando Rodríguez de Fonseca; A J Roberts; Ainhoa Bilbao; George F Koob; Miguel Navarro
Cannabinoid receptor antagonist SR141716A decreases operant ethanol self administration in rats exposed to ethanol-vapor chambers.
Zhongguo yao li xue bao = Acta pharmacologica Sinica 1999;20(12):1109-14.
1999: Yvette Akwa; Robert H Purdy; George F Koob; KT Britton
The amygdala mediates the anxiolytic-like effect of the neurosteroid allopregnanolone in rat.
Behavioural brain research 1999;106(1-2):119-25.
1999: George F Koob
Cocaine reward and dopamine receptors: love at first site.
Archives of general psychiatry 1999;56(12):1107-8.
1999: George F Koob; S C Heinrichs
A role for corticotropin releasing factor and urocortin in behavioral responses to stressors.
Brain research 1999;848(1-2):141-52.
1999: George F Koob
Corticotropin-releasing factor, norepinephrine, and stress.
Biological psychiatry 1999;46(9):1167-80.
1999: John R Walker; M King; Emanuela Izzo; George F Koob; Gavril W Pasternak
Antagonism of heroin and morphine self-administration in rats by the morphine-6beta-glucuronide antagonist 3-O-methylnaltrexone.
European journal of pharmacology 1999;383(2):115-9.
1999: Michael Weed; Michael Taffe; Ilham Polis; A C Roberts; Trevor W Robbins; George F Koob; FE Bloom; Lisa H Gold
Performance norms for a rhesus monkey neuropsychological testing battery: acquisition and long-term performance.
Brain research. Cognitive brain research 1999;8(3):185-201.
1999: G Martin; Serge H Ahmed; T Blank; J Spiess; George F Koob; George R Siggins
Chronic morphine treatment alters NMDA receptor-mediated synaptic transmission in the nucleus accumbens.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(20):9081-9.
1999: Serge H Ahmed; George F Koob
Long-lasting increase in the set point for cocaine self-administration after escalation in rats.
Psychopharmacology 1999;146(3):303-12.
1999: Charles J Heyser; Amanda J Roberts; Gery Schulteis; George F Koob
Central administration of an opiate antagonist decreases oral ethanol self-administration in rats.
Alcoholism, clinical and experimental research 1999;23(9):1468-76.
1999: George F Koob; S B Caine
Cocaine addiction therapy--are we partially there?
Nature medicine 1999;5(9):993-5.
1999: Daniel Lin; George F Koob; Athina Markou
Differential effects of withdrawal from chronic amphetamine or fluoxetine administration on brain stimulation reward in the rat--interactions between the two drugs.
Psychopharmacology 1999;145(3):283-94.
1999: Stéphanie Caillé; Emilio F Espejo; J P Reneric; Martine Cador; George F Koob; Luis Stinus
Total neurochemical lesion of noradrenergic neurons of the locus ceruleus does not alter either naloxone-precipitated or spontaneous opiate withdrawal nor does it influence ability of clonidine to reverse opiate withdrawal.
The Journal of pharmacology and experimental therapeutics 1999;290(2):881-92.
1999: Angelo Contarino; F Dellu; George F Koob; George W Smith; Kuo-Fen Lee; Wylie Vale; Lisa H Gold
Reduced anxiety-like and cognitive performance in mice lacking the corticotropin-releasing factor receptor 1.
Brain research 1999;835(1):1-9.
1999: M Solbrig; George F Koob; W Ian Lipkin
Orofacial dyskinesias and dystonia in rats infected with Borna disease virus; a model for tardive dyskinetic syndromes.
Molecular psychiatry 1999;4(4):310-2.
1999: AM Basso; MG Spina; J Rivier; W Vale; George F Koob
Corticotropin-releasing factor antagonist attenuates the "anxiogenic-like" effect in the defensive burying paradigm but not in the elevated plus-maze following chronic cocaine in rats.
Psychopharmacology 1999;145(1):21-30.
1999: Amanda J Roberts; Charles J Heyser; George F Koob
Operant self-administration of sweetened versus unsweetened ethanol: effects on blood alcohol levels.
Alcoholism, clinical and experimental research 1999;23(7):1151-7.
1999: Rong-Sheng Lee; José R Criado; George F Koob; Steven J Henriksen
Cellular responses of nucleus accumbens neurons to opiate-seeking behavior: I. Sustained responding during heroin self-administration.
Synapse (New York, N.Y.) 1999;33(1):49-58.
1999: George F Koob
The role of the striatopallidal and extended amygdala systems in drug addiction.
Annals of the New York Academy of Sciences 1999;877():445-60.
1999: José R Criado; H Li; X Jiang; M Spina; Salvador Huitrón-Reséndiz; G Liapakis; Marta Calbet; S Siehler; Steven J Henriksen; George F Koob; Daniel Hoyer; J Gregor Sutcliffe; M Goodman; Luis de Lecea
Structural and compositional determinants of cortistatin activity.
Journal of neuroscience research 1999;56(6):611-9.
1999: Gery Schulteis; Charles J Heyser; George F Koob
Differential expression of response-disruptive and somatic indices of opiate withdrawal during the initiation and development of opiate dependence.
Behavioural pharmacology 1999;10(3):235-42.
1999: M Rocío A Carrera; Gery Schulteis; George F Koob
Heroin self-administration in dependent Wistar rats: increased sensitivity to naloxone.
Psychopharmacology 1999;144(2):111-20.
1999: Loren H Parsons; George F Koob; Friedbert Weiss
RU 24969, a 5-HT1B/1A receptor agonist, potentiates cocaine-induced increases in nucleus accumbens dopamine.
Synapse (New York, N.Y.) 1999;32(2):132-5.
1999: SS Watkins; MP Epping-Jordan; George F Koob; Athina Markou
Blockade of nicotine self-administration with nicotinic antagonists in rats.
Pharmacology, biochemistry, and behavior 1999;62(4):743-51.
1999: BA Baldo; K Jain; L Veraldi; George F Koob; Athina Markou
A dopamine D1 agonist elevates self-stimulation thresholds: comparison to other dopamine-selective drugs.
Pharmacology, biochemistry, and behavior 1999;62(4):659-72.
1999: Alan I Leshner; George F Koob
Drugs of abuse and the brain.
Proceedings of the Association of American Physicians 1999;111(2):99-108.
1999: George F Koob; F Weiss; S T Tiffany; W Zieglgansberger; Rainer Spanagel
Animal models of craving: a roundtable discussion.
Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism 1999;23(3):233-6.
1999: George F Koob
Stress, corticotropin-releasing factor, and drug addiction.
Annals of the New York Academy of Sciences 1999;897():27-45.
1999: Amanda A Harrison; Loren H Parsons; George F Koob; Athina Markou
RU 24969, a 5-HT1A/1B agonist, elevates brain stimulation reward thresholds: an effect reversed by GR 127935, a 5-HT1B/1D antagonist.
Psychopharmacology 1999;141(3):242-50.
1999: BA Baldo; Athina Markou; George F Koob
Increased sensitivity to the locomotor depressant effect of a dopamine receptor antagonist during cocaine withdrawal in the rat.
Psychopharmacology 1999;141(2):135-44.
1998: Alane S Kimes; R Maldonado; E Ambrosio; George F Koob; Edythe D London
Cerebral glucose metabolism during opioid withdrawal following methylnaloxonium injection into the locus coeruleus.
Brain research 1998;814(1-2):1-12.
1998: T R Kosten; A Markou; George F Koob
Depression and stimulant dependence: neurobiology and pharmacotherapy.
The Journal of nervous and mental disease 1998;186(12):737-45.
1998: Loren H Parsons; Friedbert Weiss; George F Koob
Serotonin1B receptor stimulation enhances cocaine reinforcement.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(23):10078-89.
1998: Gery Schulteis; Luis Stinus; V B Risbrough; George F Koob
Clonidine blocks acquisition but not expression of conditioned opiate withdrawal in rats.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1998;19(5):406-16.
1998: Miguel Navarro; Julie A Chowen; M Rocío A Carrera; Ignacio Del Arco; M Angeles Villanúa; Y Martin; A J Roberts; George F Koob; Fernando Rodríguez de Fonseca
CB1 cannabinoid receptor antagonist-induced opiate withdrawal in morphine-dependent rats.
Neuroreport 1998;9(15):3397-402.
1998: Serge H Ahmed; George F Koob
Transition from moderate to excessive drug intake: change in hedonic set point.
Science (New York, N.Y.) 1998;282(5387):298-300.
1998: Amanda J Roberts; A D Smith; Friedbert Weiss; C Rivier; George F Koob
Estrous cycle effects on operant responding for ethanol in female rats.
Alcoholism, clinical and experimental research 1998;22(7):1564-9.
1998: George F Koob; P P Sanna; F E Bloom
Neuroscience of addiction.
Neuron 1998;21(3):467-76.
1998: Luigi Pulvirenti; C Balducci; M Piercy; George F Koob
Characterization of the effects of the partial dopamine agonist terguride on cocaine self-administration in the rat.
The Journal of pharmacology and experimental therapeutics 1998;286(3):1231-8.
1998: MJ Eckardt; S E File; Gian Luigi Gessa; Kathleen A Grant; C Guerri; Paula L Hoffman; H Kalant; George F Koob; Ting-Kai Li; Boris Tabakoff
Effects of moderate alcohol consumption on the central nervous system.
Alcoholism, clinical and experimental research 1998;22(5):998-1040.
1998: Rong-Sheng Lee; George F Koob; Steven J Henriksen
Electrophysiological responses of nucleus accumbens neurons to novelty stimuli and exploratory behavior in the awake, unrestrained rat.
Brain research 1998;799(2):317-22.
1998: John R Walker; M Spina; Lars Terenius; George F Koob
Nociceptin fails to affect heroin self-administration in the rat.
Neuroreport 1998;9(10):2243-7.
1998: Gery Schulteis; M Yackey; V Risbrough; George F Koob
Anxiogenic-like effects of spontaneous and naloxone-precipitated opiate withdrawal in the elevated plus-maze.
Pharmacology, biochemistry, and behavior 1998;60(3):727-31.
1998: Mary Jeanne Kreek; George F Koob
Drug dependence: stress and dysregulation of brain reward pathways.
Drug and alcohol dependence 1998;51(1-2):23-47.
1998: George W Smith; JM Aubry; F Dellu; Angelo Contarino; Louise M Bilezikjian; Lisa H Gold; R Chen; Yelena Marchuk; C Hauser; C A Bentley; Paul E Sawchenko; George F Koob; Wylie Vale; Kuo-Fen Lee
Corticotropin releasing factor receptor 1-deficient mice display decreased anxiety, impaired stress response, and aberrant neuroendocrine development.
Neuron 1998;20(6):1093-102.
1998: MP Epping-Jordan; SS Watkins; George F Koob; Athina Markou
Dramatic decreases in brain reward function during nicotine withdrawal.
Nature 1998;393(6680):76-9.
1998: Jacob Raber; O Sorg; Thomas F W Horn; N Yu; George F Koob; I L Campbell; F E Bloom
Inflammatory cytokines: putative regulators of neuronal and neuro-endocrine function.
Brain research. Brain research reviews 1998;26(2-3):320-6.
1998: A J Roberts; Robert McArthur; E E Hull; C Post; George F Koob
Effects of amperozide, 8-OH-DPAT, and FG 5974 on operant responding for ethanol.
Psychopharmacology 1998;137(1):25-32.
1998: K T Britton; George F Koob
Neuropharmacology. Premenstrual steroids?
Nature 1998;392(6679):869-70.
1998: Marylou V Solbrig; George F Koob; W Ian Lipkin
Cocaine sensitivity in Borna disease virus-infected rats.
Pharmacology, biochemistry, and behavior 1998;59(4):1047-52.
1998: Stephen C Heinrichs; A Klaassen; George F Koob; Gery Schulteis; S Ahmed; Errol B De Souza
Corticotropin-releasing factor receptor blockade enhances conditioned aversive properties of cocaine in rats.
Psychopharmacology 1998;136(3):247-55.
1998: Athina Markou; T R Kosten; George F Koob
Neurobiological similarities in depression and drug dependence: a self-medication hypothesis.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1998;18(3):135-74.
1998: MP Epping-Jordan; Athina Markou; George F Koob
The dopamine D-1 receptor antagonist SCH 23390 injected into the dorsolateral bed nucleus of the stria terminalis decreased cocaine reinforcement in the rat.
Brain research 1998;784(1-2):105-15.
1998: George F Koob; Amanda J Roberts; Gery Schulteis; Loren H Parsons; Charles J Heyser; Petri Hyytiä; E Merlo-Pich; Friedbert Weiss
Neurocircuitry targets in ethanol reward and dependence.
Alcoholism, clinical and experimental research 1998;22(1):3-9.
1998: Charles J Heyser; Gery Schulteis; P Durbin; George F Koob
Chronic acamprosate eliminates the alcohol deprivation effect while having limited effects on baseline responding for ethanol in rats.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1998;18(2):125-33.
1998: George F Koob; M Rocio; A Carrera; Lisa H Gold; Charles J Heyser; C Maldonado-Irizarry; A Markou; Loren H Parsons; Amanda J Roberts; Gery Schulteis; Luis Stinus; J R Walker; R Weissenborn; Friedbert Weiss
Substance dependence as a compulsive behavior.
Journal of psychopharmacology (Oxford, England) 1998;12(1):39-48.
1998: Stephen C Heinrichs; F Menzaghi; George F Koob
Neuropeptide Y-induced feeding and its control.
Vitamins and hormones 1998;54():51-66.
1998: George F Koob
Circuits, drugs, and drug addiction.
Advances in pharmacology (San Diego, Calif.) 1998;42():978-82.
1998: George F Koob
Drug abuse and alcoholism. Overview.
Advances in pharmacology (San Diego, Calif.) 1998;42():969-77.
1997: John R Walker; George F Koob
Orphan anxiety.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(26):14217-9.
1997: George F Koob; Michel Le Moal
Drug abuse: hedonic homeostatic dysregulation.
Science (New York, N.Y.) 1997;278(5335):52-8.
1997: Serge H Ahmed; George F Koob
Cocaine- but not food-seeking behavior is reinstated by stress after extinction.
Psychopharmacology 1997;132(3):289-95.
1997: M D Brot; Glenn F Rall; Michael B A Oldstone; George F Koob; Lisa H Gold
Deficits in discriminated learning remain despite clearance of long-term persistent viral infection in mice.
Journal of neurovirology 1997;3(4):265-73.
1997: Charles J Heyser; Gery Schulteis; George F Koob
Increased ethanol self-administration after a period of imposed ethanol deprivation in rats trained in a limited access paradigm.
Alcoholism, clinical and experimental research 1997;21(5):784-91.
1997: S B Caine; George F Koob; Loren H Parsons; Barry J Everitt; J C Schwartz; Pierre Sokoloff
D3 receptor test in vitro predicts decreased cocaine self-administration in rats.
Neuroreport 1997;8(9-10):2373-7.
1997: KT Britton; S Southerland; E Van Uden; D Kirby; J Rivier; George F Koob
Anxiolytic activity of NPY receptor agonists in the conflict test.
Psychopharmacology 1997;132(1):6-13.
1997: Charles J Heyser; JS McDonald; V Beauchamp; George F Koob; Lisa H Gold
The effects of cocaine on operant responding for food in several strains of mice.
Psychopharmacology 1997;132(2):202-8.
1997: George F Koob; S B Caine; L Parsons; Athina Markou; Friedbert Weiss
Opponent process model and psychostimulant addiction.
Pharmacology, biochemistry, and behavior 1997;57(3):513-21.
1997: V Deroche; S Barak Caine; Charles J Heyser; Ilham Polis; George F Koob; Lisa H Gold
Differences in the liability to self-administer intravenous cocaine between C57BL/6 x SJL and BALB/cByJ mice.
Pharmacology, biochemistry, and behavior 1997;57(3):429-40.
1997: Fernando Rodríguez de Fonseca; M Rocío A Carrera; Miguel Navarro; George F Koob; F Weiss
Activation of corticotropin-releasing factor in the limbic system during cannabinoid withdrawal.
Science (New York, N.Y.) 1997;276(5321):2050-4.
1997: M D Brot; Yvette Akwa; Robert H Purdy; George F Koob; KT Britton
The anxiolytic-like effects of the neurosteroid allopregnanolone: interactions with GABA(A) receptors.
European journal of pharmacology 1997;325(1):1-7.
1997: Jacob Raber; George F Koob; F E Bloom
Interferon-alpha and transforming growth factor-beta 1 regulate corticotropin-releasing factor release from the amygdala: comparison with the hypothalamic response.
Neurochemistry international 1997;30(4-5):455-63.
1997: Luigi Pulvirenti; C Balducci; George F Koob
Dextromethorphan reduces intravenous cocaine self-administration in the rat.
European journal of pharmacology 1997;321(3):279-83.
1997: Amanda J Roberts; George F Koob
The neurobiology of addiction: an overview.
Alcohol health and research world 1997;21(2):101-6.
1997: George F Koob; Eric J Nestler
The neurobiology of drug addiction.
The Journal of neuropsychiatry and clinical neurosciences 1997;9(3):482-97.
1997: Gery Schulteis; Charles J Heyser; George F Koob
Opiate withdrawal signs precipitated by naloxone following a single exposure to morphine: potentiation with a second morphine exposure.
Psychopharmacology 1997;129(1):56-65.
1996: Oscar Prospéro-García; Lisa H Gold; Howard S Fox; Ilham Polis; George F Koob; F E Bloom; Steven J Henriksen
Microglia-passaged simian immunodeficiency virus induces neurophysiological abnormalities in monkeys.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(24):14158-63.
1996: Loren H Parsons; Friedbert Weiss; George F Koob
Serotonin1b receptor stimulation enhances dopamine-mediated reinforcement.
Psychopharmacology 1996;128(2):150-60.
1996: Gery Schulteis; George F Koob
Reinforcement processes in opiate addiction: a homeostatic model.
Neurochemical research 1996;21(11):1437-54.
1996: Amanda J Roberts; M Cole; George F Koob
Intra-amygdala muscimol decreases operant ethanol self-administration in dependent rats.
Alcoholism, clinical and experimental research 1996;20(7):1289-98.
1996: M V Solbrig; George F Koob; J H Fallon; S Reid; W Ian Lipkin
Prefrontal cortex dysfunction in Borna disease virus (BDV)--infected rats.
Biological psychiatry 1996;40(7):629-36.
1996: M Spina; E Merlo-Pich; R K Chan; A M Basso; J Rivier; Wylie Vale; George F Koob
Appetite-suppressing effects of urocortin, a CRF-related neuropeptide.
Science (New York, N.Y.) 1996;273(5281):1561-4.
1996: Stephen C Heinrichs; Mary P Stenzel-Poore; Lisa H Gold; E Battenberg; F E Bloom; George F Koob; Wylie W Vale; E M Pich
Learning impairment in transgenic mice with central overexpression of corticotropin-releasing factor.
Neuroscience 1996;74(2):303-11.
1996: M E Vankova; Matthew B Weinger; D Y Chen; J B Bronson; V Motis; George F Koob
Role of central mu, delta-1, and kappa-1 opioid receptors in opioid-induced muscle rigidity in the rat.
Anesthesiology 1996;85(3):574-83.
1996: Loren H Parsons; S B Caine; Pierre Sokoloff; J C Schwartz; George F Koob; Friedbert Weiss
Neurochemical evidence that postsynaptic nucleus accumbens D3 receptor stimulation enhances cocaine reinforcement.
Journal of neurochemistry 1996;67(3):1078-89.
1996: M V Solbrig; George F Koob; Jeffrey N. Joyce; W Ian Lipkin
A neural substrate of hyperactivity in borna disease: changes in brain dopamine receptors.
Virology 1996;222(2):332-8.
1996: R Weissenborn; V Deroche; George F Koob; Friedbert Weiss
Effects of dopamine agonists and antagonists on cocaine-induced operant responding for a cocaine-associated stimulus.
Psychopharmacology 1996;126(4):311-22.
1996: F Menzaghi; Stephen C Heinrichs; M Vargas-Cortes; G Goldstein; George F Koob
IRI-514, a synthetic peptide analogue of thymopentin, reduces the behavioral response to social stress in rats.
Physiology & behavior 1996;60(2):397-401.
1996: George F Koob
Hedonic valence, dopamine and motivation.
Molecular psychiatry 1996;1(3):186-9.
1996: Juan Carlos de la Torre; Margaret Mallory; M Brot; L Gold; George F Koob; Michael B A Oldstone; Eliezer Masliah
Viral persistence in neurons alters synaptic plasticity and cognitive functions without destruction of brain cells.
Virology 1996;220(2):508-15.
1996: P Hyytiä; Gery Schulteis; George F Koob
Intravenous heroin and ethanol self-administration by alcohol-preferring AA and alcohol-avoiding ANA rats.
Psychopharmacology 1996;125(3):248-54.
1996: K Matthews; B A Baldo; Athina Markou; O Lown; David H Overstreet; George F Koob
Rewarding electrical brain stimulation: similar thresholds for Flinders Sensitive Line Hypercholinergic and Flinders Resistant Line Hypocholinergic rats.
Physiology & behavior 1996;59(6):1155-62.
1996: Friedbert Weiss; Loren H Parsons; Gery Schulteis; P Hyytiä; M T Lorang; F E Bloom; George F Koob
Ethanol self-administration restores withdrawal-associated deficiencies in accumbal dopamine and 5-hydroxytryptamine release in dependent rats.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1996;16(10):3474-85.
1996: S Mechiel Korte; G A Korte-Bouws; George F Koob; Ron de Kloet; Bela G Bohus
Mineralocorticoid and glucocorticoid receptor antagonists in animal models of anxiety.
Pharmacology, biochemistry, and behavior 1996;54(1):261-7.
1996: George F Koob
Drug addiction: the yin and yang of hedonic homeostasis.
Neuron 1996;16(5):893-6.
1996: M V Solbrig; George F Koob; W Ian Lipkin
Naloxone-induced seizures in rats infected with Borna disease virus.
Neurology 1996;46(4):1170-1.
1996: D J Macey; Gery Schulteis; Stephen C Heinrichs; George F Koob
Time-dependent quantifiable withdrawal from ethanol in the rat: effect of method of dependence induction.
Alcohol (Fayetteville, N.Y.) 1996;13(2):163-70.
1996: A H Glassman; George F Koob
Neuropharmacology. Psychoactive smoke.
Nature 1996;379(6567):677-8.
1996: G Bono; C Balducci; P Richelmi; George F Koob; Luigi Pulvirenti
Dopamine partial receptor agonists reduce ethanol intake in the rat.
European journal of pharmacology 1996;296(3):233-8.
1996: Gery Schulteis; P Hyytiä; Stephen C Heinrichs; George F Koob
Effects of chronic ethanol exposure on oral self-administration of ethanol or saccharin by Wistar rats.
Alcoholism, clinical and experimental research 1996;20(1):164-71.
1996: Luigi Pulvirenti; C Balducci; George F Koob
Inhibition of nitric oxide synthesis reduces intravenous cocaine self-administration in the rat.
Neuropharmacology 1996;35(12):1811-4.
1996: Loren H Parsons; George F Koob; Friedbert Weiss
Extracellular serotonin is decreased in the nucleus accumbens during withdrawal from cocaine self-administration.
Behavioural brain research 1996;73(1-2):225-8.
1996: Fernando Rodríguez de Fonseca; P Rubio; F Menzaghi; E Merlo-Pich; J Rivier; George F Koob; Miguel Navarro
Corticotropin-releasing factor (CRF) antagonist [D-Phe12,Nle21,38,C alpha MeLeu37]CRF attenuates the acute actions of the highly potent cannabinoid receptor agonist HU-210 on defensive-withdrawal behavior in rats.
The Journal of pharmacology and experimental therapeutics 1996;276(1):56-64.
1995: Stephen C Heinrichs; F Menzaghi; E Merlo Pich; KT Britton; George F Koob
The role of CRF in behavioral aspects of stress.
Annals of the New York Academy of Sciences 1995;771():92-104.
1995: M R Carrera; J A Ashley; Loren H Parsons; Peter Wirsching; George F Koob; Kim D Janda
Suppression of psychoactive effects of cocaine by active immunization.
Nature 1995;378(6558):727-30.
1995: S B Caine; Stephen C Heinrichs; V L Coffin; George F Koob
Effects of the dopamine D-1 antagonist SCH 23390 microinjected into the accumbens, amygdala or striatum on cocaine self-administration in the rat.
Brain research 1995;692(1-2):47-56.
1995: P Hyytiä; George F Koob
GABAA receptor antagonism in the extended amygdala decreases ethanol self-administration in rats.
European journal of pharmacology 1995;283(1-3):151-9.
1995: Loren H Parsons; George F Koob; Friedbert Weiss
Serotonin dysfunction in the nucleus accumbens of rats during withdrawal after unlimited access to intravenous cocaine.
The Journal of pharmacology and experimental therapeutics 1995;274(3):1182-91.
1995: E Merlo Pich; M Lorang; M Yeganeh; F Rodriguez de Fonseca; Jacob Raber; George F Koob; Friedbert Weiss
Increase of extracellular corticotropin-releasing factor-like immunoreactivity levels in the amygdala of awake rats during restraint stress and ethanol withdrawal as measured by microdialysis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1995;15(8):5439-47.
1995: Gery Schulteis; Athina Markou; M Cole; George F Koob
Decreased brain reward produced by ethanol withdrawal.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(13):5880-4.
1995: R Weissenborn; M Yackey; George F Koob; Friedbert Weiss
Measures of cocaine-seeking behavior using a multiple schedule of food and drug self-administration in rats.
Drug and alcohol dependence 1995;38(3):237-46.
1995: R M Richter; E M Pich; George F Koob; Friedbert Weiss
Sensitization of cocaine-stimulated increase in extracellular levels of corticotropin-releasing factor from the rat amygdala after repeated administration as determined by intracranial microdialysis.
Neuroscience letters 1995;187(3):169-72.
1995: Fernando Rodríguez de Fonseca; P Rubio; JL Martín-Calderón; S B Caine; George F Koob; Miguel Navarro
The dopamine receptor agonist 7-OH-DPAT modulates the acquisition and expression of morphine-induced place preference.
European journal of pharmacology 1995;274(1-3):47-55.
1995: Jacob Raber; George F Koob; F E Bloom
Interleukin-2 (IL-2) induces corticotropin-releasing factor (CRF) release from the amygdala and involves a nitric oxide-mediated signaling; comparison with the hypothalamic response.
The Journal of pharmacology and experimental therapeutics 1995;272(2):815-24.
1995: N W Withers; Luigi Pulvirenti; George F Koob; J Christian Gillin
Cocaine abuse and dependence.
Journal of clinical psychopharmacology 1995;15(1):63-78.
1995: Matthew B Weinger; D Y Chen; T Lin; C Lau; George F Koob; N T Smith
A role for CNS alpha-2 adrenergic receptors in opiate-induced muscle rigidity in the rat.
Brain research 1995;669(1):10-8.
1995: M D Brot; George F Koob; KT Britton
Anxiolytic effects of steroid hormones during the estrous cycle. Interactions with ethanol.
Recent developments in alcoholism : an official publication of the American Medical Society on Alcoholism, the Research Society on Alcoholism, and the National Council on Alcoholism 1995;12():243-59.
1994: M V Solbrig; George F Koob; J H Fallon; W Ian Lipkin
Tardive dyskinetic syndrome in rats infected with Borna disease virus.
Neurobiology of disease 1994;1(3):111-9.
1994: Gery Schulteis; Athina Markou; Lisa H Gold; Luis Stinus; George F Koob
Relative sensitivity to naloxone of multiple indices of opiate withdrawal: a quantitative dose-response analysis.
The Journal of pharmacology and experimental therapeutics 1994;271(3):1391-8.
1994: Luigi Pulvirenti; R Berrier; M Kreifeldt; George F Koob
Modulation of locomotor activity by NMDA receptors in the nucleus accumbens core and shell regions of the rat.
Brain research 1994;664(1-2):231-6.
1994: M Xu; Rosario Moratalla; L H Gold; Noboru Hiroi; George F Koob; Ann M Graybiel; Susumu Tonegawa
Dopamine D1 receptor mutant mice are deficient in striatal expression of dynorphin and in dopamine-mediated behavioral responses.
Cell 1994;79(4):729-42.
1994: Athina Markou; K Matthews; David H Overstreet; George F Koob; Mark A Geyer
Flinders resistant hypocholinergic rats exhibit startle sensitization and reduced startle thresholds.
Biological psychiatry 1994;36(10):680-8.
1994: Stephen C Heinrichs; F Menzaghi; E M Pich; H A Baldwin; S Rassnick; KT Britton; George F Koob
Anti-stress action of a corticotropin-releasing factor antagonist on behavioral reactivity to stressors of varying type and intensity.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1994;11(3):179-86.
1994: F Menzaghi; S Rassnick; Stephen C Heinrichs; H Baldwin; E M Pich; Friedbert Weiss; George F Koob
The role of corticotropin-releasing factor in the anxiogenic effects of ethanol withdrawal.
Annals of the New York Academy of Sciences 1994;739():176-84.
1994: Luigi Pulvirenti; George F Koob
Dopamine receptor agonists, partial agonists and psychostimulant addiction.
Trends in pharmacological sciences 1994;15(10):374-9.
1994: G Schulteis; George F Koob
Neuropharmacology. Dark side of drug dependence.
Nature 1994;371(6493):108-9.
1994: Lisa H Gold; M D Brot; Ilham Polis; R Schroeder; Antoinette Tishon; Juan Carlos de la Torre; Michael B A Oldstone; George F Koob
Behavioral effects of persistent lymphocytic choriomeningitis virus infection in mice.
Behavioral and neural biology 1994;62(2):100-9.
1994: S Mechiel Korte; G A Korte-Bouws; Bela G Bohus; George F Koob
Effect of corticotropin-releasing factor antagonist on behavioral and neuroendocrine responses during exposure to defensive burying paradigm in rats.
Physiology & behavior 1994;56(1):115-20.
1994: S B Caine; George F Koob
Effects of dopamine D-1 and D-2 antagonists on cocaine self-administration under different schedules of reinforcement in the rat.
The Journal of pharmacology and experimental therapeutics 1994;270(1):209-18.
1994: J Christian Gillin; Luigi Pulvirenti; N Withers; Shahrokh Golshan; George F Koob
The effects of lisuride on mood and sleep during acute withdrawal in stimulant abusers: a preliminary report.
Biological psychiatry 1994;35(11):843-9.
1994: Merrill M. Mitler; M S Aldrich; George F Koob; V P Zarcone
Narcolepsy and its treatment with stimulants. ASDA standards of practice.
Sleep 1994;17(4):352-71.
1994: F Menzaghi; R L Howard; Stephen C Heinrichs; Wylie Vale; J Rivier; George F Koob
Characterization of a novel and potent corticotropin-releasing factor antagonist in rats.
The Journal of pharmacology and experimental therapeutics 1994;269(2):564-72.
1994: Mary P Stenzel-Poore; Stephen C Heinrichs; S Rivest; George F Koob; Wylie W Vale
Overproduction of corticotropin-releasing factor in transgenic mice: a genetic model of anxiogenic behavior.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1994;14(5 Pt 1):2579-84.
1994: Luigi Pulvirenti; George F Koob
Lisuride reduces intravenous cocaine self-administration in rats.
Pharmacology, biochemistry, and behavior 1994;47(4):819-22.
1994: B J Cole; George F Koob
Corticotropin-releasing factor and schedule-induced polydipsia.
Pharmacology, biochemistry, and behavior 1994;47(3):393-8.
1994: S B Caine; George F Koob
Effects of mesolimbic dopamine depletion on responding maintained by cocaine and food.
Journal of the experimental analysis of behavior 1994;61(2):213-21.
1994: Jacob Raber; E M Pich; George F Koob; F E Bloom
IL-1 beta potentiates the acetylcholine-induced release of vasopressin from the hypothalamus in vitro, but not from the amygdala.
Neuroendocrinology 1994;59(3):208-17.
1994: F Menzaghi; Stephen C Heinrichs; E Merlo-Pich; F J Tilders; George F Koob
Involvement of hypothalamic corticotropin-releasing factor neurons in behavioral responses to novelty in rats.
Neuroscience letters 1994;168(1-2):139-42.
1994: Lisa H Gold; Luis Stinus; C E Inturrisi; George F Koob
Prolonged tolerance, dependence and abstinence following subcutaneous morphine pellet implantation in the rat.
European journal of pharmacology 1994;253(1-2):45-51.
1994: Markus Heilig; George F Koob; R Ekman; KT Britton
Corticotropin-releasing factor and neuropeptide Y: role in emotional integration.
Trends in neurosciences 1994;17(2):80-5.
1994: George F Koob; B Caine; Athina Markou; Luigi Pulvirenti; Friedbert Weiss
Role for the mesocortical dopamine system in the motivating effects of cocaine.
NIDA research monograph 1994;145():1-18.
1994: George F Koob; S Rassnick; Stephen C Heinrichs; Friedbert Weiss
Alcohol, the reward system and dependence.
EXS 1994;71():103-14.
1994: Luigi Pulvirenti; D Smith; George F Koob
SDZ 208-911, an amino-ergoline with partial dopamine agonist properties, dose dependently increases cocaine self-administration in the rat.
Psychopharmacology 1994;113(3-4):518-20.
1993: F Menzaghi; Stephen C Heinrichs; E M Pich; Friedbert Weiss; George F Koob
The role of limbic and hypothalamic corticotropin-releasing factor in behavioral responses to stress.
Annals of the New York Academy of Sciences 1993;697():142-54.
1993: Friedbert Weiss; M T Lorang; F E Bloom; George F Koob
Oral alcohol self-administration stimulates dopamine release in the rat nucleus accumbens: genetic and motivational determinants.
The Journal of pharmacology and experimental therapeutics 1993;267(1):250-8.
1993: S Rassnick; L Stinus; George F Koob
The effects of 6-hydroxydopamine lesions of the nucleus accumbens and the mesolimbic dopamine system on oral self-administration of ethanol in the rat.
Brain research 1993;623(1):16-24.
1993: P Robledo; R Maldonado; George F Koob
Neurotensin injected into the nucleus accumbens blocks the psychostimulant effects of cocaine but does not attenuate cocaine self-administration in the rat.
Brain research 1993;622(1-2):105-12.
1993: E M Pich; George F Koob; Markus Heilig; F Menzaghi; Wylie Vale; Friedbert Weiss
Corticotropin-releasing factor release from the mediobasal hypothalamus of the rat as measured by microdialysis.
Neuroscience 1993;55(3):695-707.
1993: F Menzaghi; Stephen C Heinrichs; E M Pich; F J Tilders; George F Koob
Functional impairment of hypothalamic corticotropin-releasing factor neurons with immunotargeted toxins enhances food intake induced by neuropeptide Y.
Brain research 1993;618(1):76-82.
1993: Neal R Swerdlow; George F Koob; M Cador; M Lorang; R L Hauger
Pituitary-adrenal axis responses to acute amphetamine in the rat.
Pharmacology, biochemistry, and behavior 1993;45(3):629-37.
1993: P Robledo; George F Koob
Two discrete nucleus accumbens projection areas differentially mediate cocaine self-administration in the rat.
Behavioural brain research 1993;55(2):159-66.
1993: S B Caine; George F Koob
Modulation of cocaine self-administration in the rat through D-3 dopamine receptors.
Science (New York, N.Y.) 1993;260(5115):1814-6.
1993: S S Negus; Steven J Henriksen; A Mattox; Gavril W Pasternak; P S Portoghese; A E Takemori; Matthew B Weinger; George F Koob
Effect of antagonists selective for mu, delta and kappa opioid receptors on the reinforcing effects of heroin in rats.
The Journal of pharmacology and experimental therapeutics 1993;265(3):1245-52.
1993: Markus Heilig; S McLeod; M Brot; Stephen C Heinrichs; F Menzaghi; George F Koob; KT Britton
Anxiolytic-like action of neuropeptide Y: mediation by Y1 receptors in amygdala, and dissociation from food intake effects.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1993;8(4):357-63.
1993: Stephen C Heinrichs; F Menzaghi; E M Pich; R L Hauger; George F Koob
Corticotropin-releasing factor in the paraventricular nucleus modulates feeding induced by neuropeptide Y.
Brain research 1993;611(1):18-24.
1993: R Maldonado; P Robledo; A J Chover; S B Caine; George F Koob
D1 dopamine receptors in the nucleus accumbens modulate cocaine self-administration in the rat.
Pharmacology, biochemistry, and behavior 1993;45(1):239-42.
1993: R P Hammer; W S Pires; A Markou; George F Koob
Withdrawal following cocaine self-administration decreases regional cerebral metabolic rate in critical brain reward regions.
Synapse (New York, N.Y.) 1993;14(1):73-80.
1993: Luigi Pulvirenti; George F Koob
Lisuride reduces psychomotor retardation during withdrawal from chronic intravenous amphetamine self-administration in rats.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1993;8(3):213-8.
1993: M Amalric; M Berhow; Ilham Polis; George F Koob
Selective effects of low-dose D2 dopamine receptor antagonism in a reaction-time task in rats.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1993;8(3):195-200.
1993: S Rassnick; J Krechman; George F Koob
Chronic ethanol produces a decreased sensitivity to the response-disruptive effects of GABA receptor complex antagonists.
Pharmacology, biochemistry, and behavior 1993;44(4):943-50.
1993: Martine Cador; B J Cole; George F Koob; Luis Stinus; Michel Le Moal
Central administration of corticotropin releasing factor induces long-term sensitization to D-amphetamine.
Brain research 1993;606(2):181-6.
1993: S Rassnick; Stephen C Heinrichs; KT Britton; George F Koob
Microinjection of a corticotropin-releasing factor antagonist into the central nucleus of the amygdala reverses anxiogenic-like effects of ethanol withdrawal.
Brain research 1993;605(1):25-32.
1993: R Maldonado; George F Koob
Destruction of the locus coeruleus decreases physical signs of opiate withdrawal.
Brain research 1993;605(1):128-38.
1993: S Rassnick; Luigi Pulvirenti; George F Koob
SDZ-205,152, a novel dopamine receptor agonist, reduces oral ethanol self-administration in rats.
Alcohol (Fayetteville, N.Y.) 1993;10(2):127-32.
1993: S S Negus; Gavril W Pasternak; George F Koob; Matthew B Weinger
Antagonist effects of beta-funaltrexamine and naloxonazine on alfentanil-induced antinociception and muscle rigidity in the rat.
The Journal of pharmacology and experimental therapeutics 1993;264(2):739-45.
1993: S Rassnick; E D'Amico; E Riley; George F Koob
GABA antagonist and benzodiazepine partial inverse agonist reduce motivated responding for ethanol.
Alcoholism, clinical and experimental research 1993;17(1):124-30.
1993: Claes Wahlestedt; E M Pich; George F Koob; Frances Yee; Markus Heilig
Modulation of anxiety and neuropeptide Y-Y1 receptors by antisense oligodeoxynucleotides.
Science (New York, N.Y.) 1993;259(5094):528-31.
1993: George F Koob; Stephen C Heinrichs; E M Pich; F Menzaghi; H Baldwin; K Miczek; KT Britton
The role of corticotropin-releasing factor in behavioural responses to stress.
Ciba Foundation symposium 1993;172():277-89; discussion 290-5.
1993: H A Baldwin; George F Koob
Rapid induction of conditioned opiate withdrawal in the rat.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1993;8(1):15-21.
1993: E M Pich; Stephen C Heinrichs; C Rivier; Klaus Miczek; D A Fisher; George F Koob
Blockade of pituitary-adrenal axis activation induced by peripheral immunoneutralization of corticotropin-releasing factor does not affect the behavioral response to social defeat stress in rats.
Psychoneuroendocrinology 1993;18(7):495-507.
1993: M Amalric; George F Koob
Functionally selective neurochemical afferents and efferents of the mesocorticolimbic and nigrostriatal dopamine system.
Progress in brain research 1993;99():209-26.
1993: Athina Markou; Friedbert Weiss; Lisa H Gold; S B Caine; Gery Schulteis; George F Koob
Animal models of drug craving.
Psychopharmacology 1993;112(2-3):163-82.
1992: Martine Cador; S H Ahmed; George F Koob; Michel Le Moal; Luis Stinus
Corticotropin-releasing factor induces a place aversion independent of its neuroendocrine role.
Brain research 1992;597(2):304-9.
1992: R Maldonado; S Negus; George F Koob
Precipitation of morphine withdrawal syndrome in rats by administration of mu-, delta- and kappa-selective opioid antagonists.
Neuropharmacology 1992;31(12):1231-41.
1992: Friedbert Weiss; M P Paulus; M T Lorang; George F Koob
Increases in extracellular dopamine in the nucleus accumbens by cocaine are inversely related to basal levels: effects of acute and repeated administration.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1992;12(11):4372-80.
1992: Athina Markou; George F Koob
Bromocriptine reverses the elevation in intracranial self-stimulation thresholds observed in a rat model of cocaine withdrawal.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1992;7(3):213-24.
1992: Luigi Pulvirenti; R Maldonado-Lopez; George F Koob
NMDA receptors in the nucleus accumbens modulate intravenous cocaine but not heroin self-administration in the rat.
Brain research 1992;594(2):327-30.
1992: Friedbert Weiss; Athina Markou; M T Lorang; George F Koob
Basal extracellular dopamine levels in the nucleus accumbens are decreased during cocaine withdrawal after unlimited-access self-administration.
Brain research 1992;593(2):314-8.
1992: Markus Heilig; S McLeod; George F Koob; KT Britton
Anxiolytic-like effect of neuropeptide Y (NPY), but not other peptides in an operant conflict test.
Regulatory peptides 1992;41(1):61-9.
1992: Stephen C Heinrichs; B J Cole; E M Pich; F Menzaghi; George F Koob; R L Hauger
Endogenous corticotropin-releasing factor modulates feeding induced by neuropeptide Y or a tail-pinch stressor.
Peptides 1992;13(5):879-84.
1992: Friedbert Weiss; Y L Hurd; U Ungerstedt; Athina Markou; Paul M Plotsky; George F Koob
Neurochemical correlates of cocaine and ethanol self-administration.
Annals of the New York Academy of Sciences 1992;654():220-41.
1992: George F Koob
Neural mechanisms of drug reinforcement.
Annals of the New York Academy of Sciences 1992;654():171-91.
1992: P Robledo; R Maldonado-Lopez; George F Koob
Role of dopamine receptors in the nucleus accumbens in the rewarding properties of cocaine.
Annals of the New York Academy of Sciences 1992;654():509-12.
1992: S Rassnick; E D'Amico; E Riley; Luigi Pulvirenti; W Zieglgänsberger; George F Koob
GABA and nucleus accumbens glutamate neurotransmission modulate ethanol self-administration in rats.
Annals of the New York Academy of Sciences 1992;654():502-5.
1992: Martine Cador; S Dumas; B J Cole; J Mallet; George F Koob; Michel Le Moal; Luis Stinus
Behavioral sensitization induced by psychostimulants or stress: search for a molecular basis and evidence for a CRF-dependent phenomenon.
Annals of the New York Academy of Sciences 1992;654():416-20.
1992: Stephen C Heinrichs; E M Pich; Klaus Miczek; KT Britton; George F Koob
Corticotropin-releasing factor antagonist reduces emotionality in socially defeated rats via direct neurotropic action.
Brain research 1992;581(2):190-7.
1992: George F Koob
Drugs of abuse: anatomy, pharmacology and function of reward pathways.
Trends in pharmacological sciences 1992;13(5):177-84.
1992: R Maldonado; Luis Stinus; Lisa H Gold; George F Koob
Role of different brain structures in the expression of the physical morphine withdrawal syndrome.
The Journal of pharmacology and experimental therapeutics 1992;261(2):669-77.
1992: George F Koob; R Maldonado; L Stinus
Neural substrates of opiate withdrawal.
Trends in neurosciences 1992;15(5):186-91.
1992: S B Weinberger; George F Koob; Joe Martinez
Differences in one-way active avoidance learning in mice of three inbred strains.
Behavior genetics 1992;22(2):177-88.
1992: KT Britton; S McLeod; George F Koob; R Hauger
Pregnane steroid alphaxalone attenuates anxiogenic behavioral effects of corticotropin releasing factor and stress.
Pharmacology, biochemistry, and behavior 1992;41(2):399-403.
1992: Athina Markou; George F Koob
Construct validity of a self-stimulation threshold paradigm: effects of reward and performance manipulations.
Physiology & behavior 1992;51(1):111-9.
1992: S Rassnick; George F Koob; Mark A Geyer
Responding to acoustic startle during chronic ethanol intoxication and withdrawal.
Psychopharmacology 1992;106(3):351-8.
1992: S Rassnick; Luigi Pulvirenti; George F Koob
Oral ethanol self-administration in rats is reduced by the administration of dopamine and glutamate receptor antagonists into the nucleus accumbens.
Psychopharmacology 1992;109(1-2):92-8.
1992: Stephen C Heinrichs; George F Koob
Corticotropin-releasing factor modulates dietary preference in nutritionally and physically stressed rats.
Psychopharmacology 1992;109(1-2):177-84.
1992: Athina Markou; R L Hauger; George F Koob
Desmethylimipramine attenuates cocaine withdrawal in rats.
Psychopharmacology 1992;109(3):305-14.
1992: George F Koob; Friedbert Weiss
Neuropharmacology of cocaine and ethanol dependence.
Recent developments in alcoholism : an official publication of the American Medical Society on Alcoholism, the Research Society on Alcoholism, and the National Council on Alcoholism 1992;10():201-33.
1992: George F Koob
Neurobiological mechanisms in cocaine and opiate dependence.
Research publications - Association for Research in Nervous and Mental Disease 1992;70():79-92.
1991: Luigi Pulvirenti; Neal R Swerdlow; George F Koob
Nucleus accumbens NMDA antagonist decreases locomotor activity produced by cocaine, heroin or accumbens dopamine, but not caffeine.
Pharmacology, biochemistry, and behavior 1991;40(4):841-5.
1991: Stephen C Heinrichs; KT Britton; George F Koob
Both conditioned taste preference and aversion induced by corticotropin-releasing factor.
Pharmacology, biochemistry, and behavior 1991;40(4):717-21.
1991: H A Baldwin; T L Wall; M A Schuckit; George F Koob
Differential effects of ethanol on punished responding in the P and NP rats.
Alcoholism, clinical and experimental research 1991;15(4):700-4.
1991: Neal R Swerdlow; R Hauger; M Irwin; George F Koob; KT Britton; Luigi Pulvirenti
Endocrine, immune, and neurochemical changes in rats during withdrawal from chronic amphetamine intoxication.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1991;5(1):23-31.
1991: KT Britton; M Page; H Baldwin; George F Koob
Anxiolytic activity of steroid anesthetic alphaxalone.
The Journal of pharmacology and experimental therapeutics 1991;258(1):124-9.
1991: Matthew B Weinger; N T Smith; T A Blasco; George F Koob
Brain sites mediating opiate-induced muscle rigidity in the rat: methylnaloxonium mapping study.
Brain research 1991;544(2):181-90.
1991: R L Schroeder; M B Weinger; L Vakassian; George F Koob
Methylnaloxonium diffuses out of the rat brain more slowly than naloxone after direct intracerebral injection.
Neuroscience letters 1991;121(1-2):173-7.
1991: H A Baldwin; S Rassnick; J Rivier; George F Koob; KT Britton
CRF antagonist reverses the "anxiogenic" response to ethanol withdrawal in the rat.
Psychopharmacology 1991;103(2):227-32.
1991: A Markou; George F Koob
Postcocaine anhedonia. An animal model of cocaine withdrawal.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1991;4(1):17-26.
1991: George F Koob; Neal R Swerdlow; Flora M Vaccarino; C Hubner; Luigi Pulvirenti; Friedbert Weiss
Functional output of the basal forebrain.
Advances in experimental medicine and biology 1991;295():291-305.
1990: Cindy L Ehlers; R I Chaplin; George F Koob
EEG effects of Ro 15-4513 and FG 7142 alone and in combination with ethanol.
Pharmacology, biochemistry, and behavior 1990;36(3):607-11.
1990: George F Koob; F Weiss
Pharmacology of drug self-administration.
Alcohol (Fayetteville, N.Y.) 1990;7(3):193-7.
1990: B J Cole; Martine Cador; Luis Stinus; J Rivier; W Vale; George F Koob; Michel Le Moal
Central administration of a CRF antagonist blocks the development of stress-induced behavioral sensitization.
Brain research 1990;512(2):343-6.
1990: M B Weinger; George F Koob
What constitutes adequate anesthesia in animals? In neonates?
Anesthesiology 1990;72(4):767-9.
1990: C B Hubner; George F Koob
Bromocriptine produces decreases in cocaine self-administration in the rat.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1990;3(2):101-8.
1990: Luigi Pulvirenti; George F Koob
The neural substrates of drug addiction and dependence.
Functional neurology 1990;5(2):109-19.
1990: Matthew B Weinger; J F Schreiber; George F Koob
Effects of two benzodiazepine inverse agonists, RO 15-4513 and FG 7142, on recovery from pentobarbital and halothane anesthesia in the rat.
Pharmacology, biochemistry, and behavior 1990;35(4):889-95.
1990: Y L Hurd; Friedbert Weiss; George F Koob; U Ungerstedt
The influence of cocaine self-administration on in vivo dopamine and acetylcholine neurotransmission in rat caudate-putamen.
Neuroscience letters 1990;109(1-2):227-33.
1990: C B Hubner; George F Koob
The ventral pallidum plays a role in mediating cocaine and heroin self-administration in the rat.
Brain research 1990;508(1):20-9.
1990: F Weiss; M Mitchiner; F E Bloom; George F Koob
Free-choice responding for ethanol versus water in alcohol preferring (P) and unselected Wistar rats is differentially modified by naloxone, bromocriptine, and methysergide.
Psychopharmacology 1990;101(2):178-86.
1990: Neal R Swerdlow; R S Mansbach; Mark A Geyer; Luigi Pulvirenti; George F Koob; D L Braff
Amphetamine disruption of prepulse inhibition of acoustic startle is reversed by depletion of mesolimbic dopamine.
Psychopharmacology 1990;100(3):413-6.
1990: K F Melia; George F Koob; C L Ehlers
Ethanol effects on delayed spatial matching as modeled by a negative exponential forgetting function.
Psychopharmacology 1990;102(3):391-8.
1990: B J Cole; Martine Cador; Luis Stinus; C Rivier; J Rivier; W Vale; Michel Le Moal; George F Koob
Critical role of the hypothalamic pituitary adrenal axis in amphetamine-induced sensitization of behavior.
Life sciences 1990;47(19):1715-20.
1990: L Stinus; M Le Moal; George F Koob
Nucleus accumbens and amygdala are possible substrates for the aversive stimulus effects of opiate withdrawal.
Neuroscience 1990;37(3):767-73.
1990: George F Koob; B J Cole; Neal R Swerdlow; Michel Le Moal; KT Britton
Stress, performance, and arousal: focus on CRF.
NIDA research monograph 1990;97():163-76.
1989: Ellen M Unterwald; A Tempel; George F Koob; R Suzanne Zukin
Characterization of opioid receptors in rat nucleus accumbens following mesolimbic dopaminergic lesions.
Brain research 1989;505(1):111-8.
1989: Neal R Swerdlow; KT Britton; George F Koob
Potentiation of acoustic startle by corticotropin-releasing factor (CRF) and by fear are both reversed by alpha-helical CRF (9-41).
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1989;2(4):285-92.
1989: George F Koob; C Lebrun; R M Bluthé; Robert Dantzer; Michel Le Moal
Role of neuropeptides in learning versus performance: focus on vasopressin.
Brain research bulletin 1989;23(4-5):359-64.
1989: Y L Hurd; Friedbert Weiss; George F Koob; N E And; U Ungerstedt
Cocaine reinforcement and extracellular dopamine overflow in rat nucleus accumbens: an in vivo microdialysis study.
Brain research 1989;498(1):199-203.
1989: Luigi Pulvirenti; N R Swerdlow; George F Koob
Microinjection of a glutamate antagonist into the nucleus accumbens reduces psychostimulant locomotion in rats.
Neuroscience letters 1989;103(2):213-8.
1989: Neal R Swerdlow; George F Koob
Norepinephrine stimulates behavioral activation in rats following depletion of nucleus accumbens dopamine.
Pharmacology, biochemistry, and behavior 1989;33(3):595-9.
1989: George F Koob; Luis Stinus; Michel Le Moal; F E Bloom
Opponent process theory of motivation: neurobiological evidence from studies of opiate dependence.
Neuroscience and biobehavioral reviews 1989;13(2-3):135-40.
1989: M Amalric; George F Koob
Dorsal pallidum as a functional motor output of the corpus striatum.
Brain research 1989;483(2):389-94.
1989: K T Britton; George F Koob
Effects of corticotropin releasing factor, desipramine and haloperidol on a DRL schedule of reinforcement.
Pharmacology, biochemistry, and behavior 1989;32(4):967-70.
1989: L H Gold; Mark A Geyer; George F Koob
Psychostimulant properties of MDMA.
NIDA research monograph 1989;95():345-6.
1989: F Weiss; Aaron Ettenberg; George F Koob
CCK-8 injected into the nucleus accumbens attenuates the supersensitive locomotor response to apomorphine in 6-OHDA and chronic-neuroleptic treated rats.
Psychopharmacology 1989;99(3):409-15.
1989: L H Gold; George F Koob
MDMA produces stimulant-like conditioned locomotor activity.
Psychopharmacology 1989;99(3):352-6.
1989: L H Gold; C B Hubner; George F Koob
A role for the mesolimbic dopamine system in the psychostimulant actions of MDMA.
Psychopharmacology 1989;99(1):40-7.
1989: L H Gold; Mark A Geyer; George F Koob
Neurochemical mechanisms involved in behavioral effects of amphetamines and related designer drugs.
NIDA research monograph 1989;94():101-26.
1989: B J Cole; George F Koob
Low doses of corticotropin-releasing factor potentiate amphetamine-induced stereotyped behavior.
Psychopharmacology 1989;99(1):27-33.
1989: George F Koob; T L Wall; F E Bloom
Nucleus accumbens as a substrate for the aversive stimulus effects of opiate withdrawal.
Psychopharmacology 1989;98(4):530-4.
1988: T H Hand; George F Koob; Luis Stinus; Michel Le Moal
Aversive properties of opiate receptor blockade: evidence for exclusively central mediation in naive and morphine-dependent rats.
Brain research 1988;474(2):364-8.
1988: B J Cole; George F Koob
Propranolol antagonizes the enhanced conditioned fear produced by corticotropin releasing factor.
The Journal of pharmacology and experimental therapeutics 1988;247(3):902-10.
1988: George F Koob; F E Bloom
Cellular and molecular mechanisms of drug dependence.
Science (New York, N.Y.) 1988;242(4879):715-23.
1988: George F Koob; L Percy; K T Britton
The effects of Ro 15-4513 on the behavioral actions of ethanol in an operant reaction time task and a conflict test.
Pharmacology, biochemistry, and behavior 1988;31(3):757-60.
1988: L H Gold; George F Koob; Mark A Geyer
Stimulant and hallucinogenic behavioral profiles of 3,4-methylenedioxymethamphetamine and N-ethyl-3,4-methylenedioxyamphetamine in rats.
The Journal of pharmacology and experimental therapeutics 1988;247(2):547-55.
1988: George F Koob; W B Mendelson; J Schafer; T L Wall; K T Britton; F E Bloom
Picrotoxinin receptor ligand blocks anti-punishment effects of alcohol.
Alcohol (Fayetteville, N.Y.) 1988;5(6):437-43.
1988: Robert Dantzer; George F Koob; R M Bluthé; M Le Moal
Septal vasopressin modulates social memory in male rats.
Brain research 1988;457(1):143-7.
1988: L H Gold; N R Swerdlow; George F Koob
The role of mesolimbic dopamine in conditioned locomotion produced by amphetamine.
Behavioral neuroscience 1988;102(4):544-52.
1988: Matthew B Weinger; E J Cline; N T Smith; T A Blasco; George F Koob
Localization of brainstem sites which mediate alfentanil-induced muscle rigidity in the rat.
Pharmacology, biochemistry, and behavior 1988;29(3):573-80.
1988: L H Gold; George F Koob
Methysergide potentiates the hyperactivity produced by MDMA in rats.
Pharmacology, biochemistry, and behavior 1988;29(3):645-8.
1988: K T Britton; C L Ehlers; George F Koob
Is ethanol antagonist Ro15-4513 selective for ethanol?
Science (New York, N.Y.) 1988;239(4840):648-50.
1988: Robert Dantzer; C Terlouw; A Tazi; J M Koolhaas; B Bohus; George F Koob; M Le Moal
The propensity for schedule-induced polydipsia is related to differences in conditioned avoidance behaviour and in defense reactions in a defeat test.
Physiology & behavior 1988;43(3):269-73.
1988: George F Koob; C B Hubner
Reinforcement pathways for cocaine.
NIDA research monograph 1988;88():137-59.
1988: K T Britton; G Lee; George F Koob
Corticotropin releasing factor and amphetamine exaggerate partial agonist properties of benzodiazepine antagonist Ro 15-1788 in the conflict test.
Psychopharmacology 1988;94(3):306-11.
1988: George F Koob; K Thatcher-Briton; A Tazi; M Le Moal
Behavioral pharmacology of stress: Focus on CNS corticotropin-releasing factor.
Advances in experimental medicine and biology 1988;245():25-34.
1988: George F Koob; N R Swerdlow
The functional output of the mesolimbic dopamine system.
Annals of the New York Academy of Sciences 1988;537():216-27.
1988: Franco J Vaccarino; David Feifel; J Rivier; W Vale; George F Koob
Centrally administered hypothalamic growth hormone-releasing factor stimulates food intake in free-feeding rats.
Peptides 1988;9 Suppl 1():35-8.
1987: George F Koob; T L Wall; J Schafer
Rapid induction of tolerance to the antipunishment effects of ethanol.
Alcohol (Fayetteville, N.Y.) 1987;4(6):481-4.
1987: Matthew B Weinger; E J Cline; N T Smith; George F Koob
Ketanserin pretreatment reverses alfentanil-induced muscle rigidity.
Anesthesiology 1987;67(3):348-54.
1987: George F Koob; H T Le; I Creese
The D1 dopamine receptor antagonist SCH 23390 increases cocaine self-administration in the rat.
Neuroscience letters 1987;79(3):315-20.
1987: A Tazi; N R Swerdlow; M LeMoal; J Rivier; W Vale; George F Koob
Behavioral activation by CRF: evidence for the involvement of the ventral forebrain.
Life sciences 1987;41(1):41-9.
1987: A Tazi; Robert Dantzer; M Le Moal; J Rivier; W Vale; George F Koob
Corticotropin-releasing factor antagonist blocks stress-induced fighting in rats.
Regulatory peptides 1987;18(1):37-42.
1987: M Amalric; George F Koob
Depletion of dopamine in the caudate nucleus but not in nucleus accumbens impairs reaction-time performance in rats.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1987;7(7):2129-34.
1987: M Le Moal; Robert Dantzer; B Michaud; George F Koob
Centrally injected arginine vasopressin (AVP) facilitates social memory in rats.
Neuroscience letters 1987;77(3):353-9.
1987: N R Swerdlow; George F Koob
Lesions of the dorsomedial nucleus of the thalamus, medial prefrontal cortex and pedunculopontine nucleus: effects on locomotor activity mediated by nucleus accumbens-ventral pallidal circuitry.
Brain research 1987;412(2):233-43.
1987: N R Swerdlow; M Amalric; George F Koob
Nucleus accumbens opiate-dopamine interactions and locomotor activation in the rat: evidence for a pre-synaptic locus.
Pharmacology, biochemistry, and behavior 1987;26(4):765-9.
1987: C Lebrun; M Le Moal; Robert Dantzer; F E Bloom; George F Koob
Hypertonic saline mimics the effects of vasopressin on inhibitory avoidance in the rat.
Behavioral and neural biology 1987;47(2):130-7.
1987: George F Koob
Neural substrates of opioid tolerance and dependence.
NIDA research monograph 1987;76():46-52.
1987: Robert Dantzer; R M Bluthe; George F Koob; M Le Moal
Modulation of social memory in male rats by neurohypophyseal peptides.
Psychopharmacology 1987;91(3):363-8.
1987: M Amalric; E J Cline; Joe Martinez; F E Bloom; George F Koob
Rewarding properties of beta-endorphin as measured by conditioned place preference.
Psychopharmacology 1987;91(1):14-9.
1986: K Thatcher-Britton; George F Koob
Alcohol reverses the proconflict effect of corticotropin-releasing factor.
Regulatory peptides 1986;16(3-4):315-20.
1986: M Amalric; George F Koob; I Creese; N R Swerdlow
"Selective" D-1 and D-2 receptor antagonists fail to differentially alter supersensitive locomotor behavior in the rat.
Life sciences 1986;39(21):1985-93.
1986: T A Blasco; D Lee; M Amalric; N R Swerdlow; N T Smith; George F Koob
The role of the nucleus raphe pontis and the caudate nucleus in alfentanil rigidity in the rat.
Brain research 1986;386(1-2):280-6.
1986: M Amalric; T A Blasco; N T Smith; D E Lee; N R Swerdlow; George F Koob
'Catatonia' produced by alfentanil is reversed by methylnaloxonium microinjections into the brain.
Brain research 1986;386(1-2):287-95.
1986: K T Britton; G Lee; R Dana; S C Risch; George F Koob
Activating and 'anxiogenic' effects of corticotropin releasing factor are not inhibited by blockade of the pituitary-adrenal system with dexamethasone.
Life sciences 1986;39(14):1281-6.
1986: N S Downs; K T Britton; D M Gibbs; George F Koob; N R Swerdlow
Supersensitive endocrine response to physostigmine in dopamine-depleted rats: a model of depression?
Biological psychiatry 1986;21(8-9):775-86.
1986: N R Swerdlow; F J Vaccarino; M Amalric; George F Koob
The neural substrates for the motor-activating properties of psychostimulants: a review of recent findings.
Pharmacology, biochemistry, and behavior 1986;25(1):233-48.
1986: K F Melia; C L Ehlers; C J LeBrun; George F Koob
Post-learning ethanol effects on a water-finding task in rats.
Pharmacology, biochemistry, and behavior 1986;24(6):1813-5.
1986: K T Britton; G Lee; W Vale; J Rivier; George F Koob
Corticotropin releasing factor (CRF) receptor antagonist blocks activating and 'anxiogenic' actions of CRF in the rat.
Brain research 1986;369(1-2):303-6.
1986: George F Koob; Robert Dantzer; R M Bluthé; C Lebrun; F E Bloom; M Le Moal
Central injections of arginine vasopressin prolong extinction of active avoidance.
Peptides 1986;7(2):213-8.
1986: S N Deyo; W J Shoemaker; A Ettenberg; F E Bloom; George F Koob
Subcutaneous administration of behaviorally effective doses of arginine vasopressin change brain AVP content only in median eminence.
Neuroendocrinology 1986;42(3):260-6.
1986: N R Swerdlow; George F Koob; J B Aldenhoff
The effects of verapamil on the locomotor-activating properties of corticotropin releasing factor (CRF) in the rat.
Psychoneuroendocrinology 1986;11(2):237-40.
1986: George F Koob; C Braestrup; K Thatcher Britton
The effects of FG 7142 and RO 15-1788 on the release of punished responding produced by chlordiazepoxide and ethanol in the rat.
Psychopharmacology 1986;90(2):173-8.
1986: N R Swerdlow; Mark A Geyer; W W Vale; George F Koob
Corticotropin-releasing factor potentiates acoustic startle in rats: blockade by chlordiazepoxide.
Psychopharmacology 1986;88(2):147-52.
1986: F J Vaccarino; M Amalric; N R Swerdlow; George F Koob
Blockade of amphetamine but not opiate-induced locomotion following antagonism of dopamine function in the rat.
Pharmacology, biochemistry, and behavior 1986;24(1):61-5.
1986: N R Swerdlow; D L Braff; Mark A Geyer; George F Koob
Central dopamine hyperactivity in rats mimics abnormal acoustic startle response in schizophrenics.
Biological psychiatry 1986;21(1):23-33.
1986: George F Koob; F J Vaccarino; M Amalric; F E Bloom
Neurochemical substrates for opiate reinforcement.
NIDA research monograph 1986;71():146-64.
1985: N R Swerdlow; D Lee; George F Koob; F J Vaccarino
Effects of chronic dietary lithium on behavioral indices of dopamine denervation supersensitivity in the rat.
The Journal of pharmacology and experimental therapeutics 1985;235(2):324-9.
1985: N R Swerdlow; F J Vaccarino; George F Koob
Effects of naloxone on heroin-, amphetamine- and caffeine-stimulated locomotor activity in the rat.
Pharmacology, biochemistry, and behavior 1985;23(3):499-501.
1985: F J Vaccarino; H O Pettit; F E Bloom; George F Koob
Effects of intracerebroventricular administration of methyl naloxonium chloride on heroin self-administration in the rat.
Pharmacology, biochemistry, and behavior 1985;23(3):495-8.
1985: M Amalric; George F Koob
Low doses of methylnaloxonium in the nucleus accumbens antagonize hyperactivity induced by heroin in the rat.
Pharmacology, biochemistry, and behavior 1985;23(3):411-5.
1985: M Eaves; K Thatcher-Britton; J Rivier; W Vale; George F Koob
Effects of corticotropin releasing factor on locomotor activity in hypophysectomized rats.
Peptides 1985;6(5):923-6.
1985: N R Swerdlow; George F Koob
Separate neural substrates of the locomotor-activating properties of amphetamine, heroin, caffeine and corticotropin releasing factor (CRF) in the rat.
Pharmacology, biochemistry, and behavior 1985;23(2):303-7.
1985: George F Koob; Robert Dantzer; F Rodriguez; F E Bloom; M Le Moal
Osmotic stress mimics effects of vasopressin on learned behaviour.
Nature 1985;315(6022):750-2.
1985: C Lebrun; M Le Moal; George F Koob; F E Bloom
Vasopressin pressor antagonist injected centrally reverses behavioral effects of peripheral injection of vasopressin, but only at doses that reverse increase in blood pressure.
Regulatory peptides 1985;11(2):173-81.
1985: F J Vaccarino; F E Bloom; J Rivier; W Vale; George F Koob
Stimulation of food intake in rats by centrally administered hypothalamic growth hormone-releasing factor.
Nature 1985;314(6007):167-8.
1985: C L Ehlers; George F Koob
Locomotor behavior following kindling in three different brain sites.
Brain research 1985;326(1):71-9.
1985: C L Ehlers; George F Koob
The effects of chronic lithium on the EEG and locomotor response to drug challenge in rats.
Progress in neuro-psychopharmacology & biological psychiatry 1985;9(2):133-42.
1985: C L Ehlers; T K Reed; M Wang; C J Lebrun; George F Koob
EEG effects of subcutaneous and intracerebroventricular injections of arginine vasopressin in the rat.
Psychopharmacology 1985;87(4):430-3.
1985: K T Britton; J Morgan; J Rivier; W Vale; George F Koob
Chlordiazepoxide attenuates response suppression induced by corticotropin-releasing factor in the conflict test.
Psychopharmacology 1985;86(1-2):170-4.
1985: George F Koob; K Thatcher-Britton
Stimulant and anxiogenic effects of corticotropin releasing factor.
Progress in clinical and biological research 1985;192():499-506.
1985: George F Koob; F E Bloom
Corticotropin-releasing factor and behavior.
Federation proceedings 1985;44(1 Pt 2):259-63.
1985: George F Koob; C Lebrun; Joe Martinez; Robert Dantzer; M Le Moal; F E Bloom
Arginine vasopressin, stress, and memory.
Annals of the New York Academy of Sciences 1985;444():194-202.
1985: F J Vaccarino; F E Bloom; George F Koob
Blockade of nucleus accumbens opiate receptors attenuates intravenous heroin reward in the rat.
Psychopharmacology 1985;86(1-2):37-42.
1984: N R Swerdlow; George F Koob
The neural substrates of apomorphine-stimulated locomotor activity following denervation of the nucleus accumbens.
Life sciences 1984;35(25):2537-44.
1984: F J Vaccarino; George F Koob
Microinjections of nanogram amounts of sulfated cholecystokinin octapeptide into the rat nucleus accumbens attenuates brain stimulation reward.
Neuroscience letters 1984;52(1-2):61-6.
1984: George F Koob; N Swerdlow; M Seeligson; M Eaves; R Sutton; J Rivier; W Vale
Effects of alpha-flupenthixol and naloxone on CRF-induced locomotor activation.
Neuroendocrinology 1984;39(5):459-64.
1984: C J LeBrun; H Rigter; Joe Martinez; George F Koob; M Le Moal; F E Bloom
Antagonism of effects of vasopressin (AVP) on inhibitory avoidance by a vasopressin antagonist peptide [dPtyr(Me)AVP].
Life sciences 1984;35(14):1505-12.
1984: Donald E Moss; George F Koob; S B McMaster; David S Janowsky
Comparative effects of tetrahydrocannabinol on psychostimulant-induced behaviors.
Pharmacology, biochemistry, and behavior 1984;21(4):641-4.
1984: N R Swerdlow; L W Swanson; George F Koob
Substantia innominata: critical link in the behavioral expression of mesolimbic dopamine stimulation in the rat.
Neuroscience letters 1984;50(1-3):19-24.
1984: George F Koob; K Thatcher-Britton; D R Britton; David Roberts; F E Bloom
Destruction of the locus coeruleus or the dorsal NE bundle does not alter the release of punished responding by ethanol and chlordiazepoxide.
Physiology & behavior 1984;33(3):479-85.
1984: D R Britton; C Ksir; K T Britton; D Young; George F Koob
Brain norepinephrine depleting lesions selectively enhance behavioral responsiveness to novelty.
Physiology & behavior 1984;33(3):473-8.
1984: N R Swerdlow; L W Swanson; George F Koob
Electrolytic lesions of the substantia innominata and lateral preoptic area attenuate the 'supersensitive' locomotor response to apomorphine resulting from denervation of the nucleus accumbens.
Brain research 1984;306(1-2):141-8.
1984: George F Koob; H Simon; J P Herman; M Le Moal
Neuroleptic-like disruption of the conditioned avoidance response requires destruction of both the mesolimbic and nigrostriatal dopamine systems.
Brain research 1984;303(2):319-29.
1984: George F Koob; H O Pettit; A Ettenberg; F E Bloom
Effects of opiate antagonists and their quaternary derivatives on heroin self-administration in the rat.
The Journal of pharmacology and experimental therapeutics 1984;229(2):481-6.
1984: K T Britton; T Svensson; J Schwartz; F E Bloom; George F Koob
Dorsal noradrenergic bundle lesions fail to alter opiate withdrawal or suppression of opiate withdrawal by clonidine.
Life sciences 1984;34(2):133-9.
1984: A Ettenberg; George F Koob
Different effects of cholecystokinin and satiety on lateral hypothalamic self-stimulation.
Physiology & behavior 1984;32(1):127-30.
1984: M Le Moal; Robert Dantzer; P Mormède; A Baduel; C Lebrun; A Ettenberg; D van der Kooy; J Wenger; S Deyo; George F Koob
Behavioral effects of peripheral administration of arginine vasopressin: a review of our search for a mode of action and a hypothesis.
Psychoneuroendocrinology 1984;9(4):319-41.
1984: H O Pettit; A Ettenberg; F E Bloom; George F Koob
Destruction of dopamine in the nucleus accumbens selectively attenuates cocaine but not heroin self-administration in rats.
Psychopharmacology 1984;84(2):167-73.
1984: N R Swerdlow; George F Koob
Restrained rats learn amphetamine-conditioned locomotion, but not place preference.
Psychopharmacology 1984;84(2):163-6.
1984: S Aston-Jones; Gary S. Aston-Jones; George F Koob
Cocaine antagonizes anxiolytic effects of ethanol.
Psychopharmacology 1984;84(1):28-31.
1983: N R Swerdlow; D van der Kooy; George F Koob; J R Wenger
Cholecystokinin produces conditioned place-aversions, not place-preferences, in food-deprived rats: evidence against involvement in satiety.
Life sciences 1983;32(18):2087-93.
1983: A Ettenberg; M Le Moal; George F Koob; F E Bloom
Vasopressin potentiation in the performance of a learned appetitive task: reversal by a pressor antagonist analog of vasopressin.
Pharmacology, biochemistry, and behavior 1983;18(4):645-7.
1983: A Ettenberg; D van der Kooy; M Le Moal; George F Koob; F E Bloom
Can aversive properties of (peripherally-injected) vasopressin account for its putative role in memory?
Behavioural brain research 1983;7(3):331-50.
1983: Trevor W Robbins; David Roberts; George F Koob
Effects of d-amphetamine and apomorphine upon operant behavior and schedule-induced licking in rats with 6-hydroxydopamine-induced lesions of the nucleus accumbens.
The Journal of pharmacology and experimental therapeutics 1983;224(3):662-73.
1983: D van der Kooy; N R Swerdlow; George F Koob
Paradoxical reinforcing properties of apomorphine: effects of nucleus accumbens and area postrema lesions.
Brain research 1983;259(1):111-8.
1983: C L Ehlers; J H Indik; George F Koob; F E Bloom
The effect of single and repeated electroconvulsive shock (ECS) on locomotor activity in rats.
Progress in neuro-psychopharmacology & biological psychiatry 1983;7(2-3):217-22.
1983: George F Koob; F E Bloom
Behavioural effects of opioid peptides.
British medical bulletin 1983;39(1):89-94.
1983: W Vale; C Rivier; M R Brown; J Spiess; George F Koob; L Swanson; L Bilezikjian; F Bloom; J Rivier
Chemical and biological characterization of corticotropin releasing factor.
Recent progress in hormone research 1983;39():245-70.
1982: David Roberts; George F Koob
Disruption of cocaine self-administration following 6-hydroxydopamine lesions of the ventral tegmental area in rats.
Pharmacology, biochemistry, and behavior 1982;17(5):901-4.
1982: R E Strecker; David Roberts; George F Koob
Apomorphine-induced facilitation of intracranial self-stimulation following dopamine denervation of the nucleus accumbens.
Pharmacology, biochemistry, and behavior 1982;17(5):1015-8.
1982: C L Ehlers; George F Koob; F E Bloom
Post-ictal locomotor activity in three different rat models of epilepsy.
Brain research 1982;250(1):178-82.
1982: P J Fray; George F Koob; S D Iversen
Tail-pinch-elicited behavior in rats: preference, plasticity, and learning.
Behavioral and neural biology 1982;36(2):108-25.
1982: J M Schwartz; C Ksir; George F Koob; F E Bloom
Changes in locomotor response to beta-endorphin microinfusion during and after opiate abstinence syndrome--a proposal for a model of the onset of mania.
Psychiatry research 1982;7(2):153-61.
1982: D A Staunton; P J Magistretti; George F Koob; W J Shoemaker; F E Bloom
Dopaminergic supersensitivity induced by denervation and chronic receptor blockade is additive.
Nature 1982;299(5878):72-4.
1982: D R Britton; George F Koob; J Rivier; W Vale
Intraventricular corticotropin-releasing factor enhances behavioral effects of novelty.
Life sciences 1982;31(4):363-7.
1982: R E Sutton; George F Koob; M Le Moal; J Rivier; W Vale
Corticotropin releasing factor produces behavioural activation in rats.
Nature 1982;297(5864):331-3.
1982: George F Koob; F E Bloom
Behavioral effects of neuropeptides: endorphins and vasopressin.
Annual review of physiology 1982;44():571-82.
1982: A Ettenberg; H O Pettit; F E Bloom; George F Koob
Heroin and cocaine intravenous self-administration in rats: mediation by separate neural systems.
Psychopharmacology 1982;78(3):204-9.
1981: George F Koob; L Stinus; M Le Moal
Hyperactivity and hypoactivity produced by lesions to the mesolimbic dopamine system.
Behavioural brain research 1981;3(3):341-59.
1981: E M Joyce; George F Koob; R Strecker; S D Iversen; F E Bloom
The behavioural effects of enkephalin analogues injected into the ventral tegmental area and globus pallidus.
Brain research 1981;221(2):359-70.
1981: A Ettenberg; Joseph Rogers; George F Koob; F E Bloom; J A Deutsch
Endogenous opiates and fasting.
Science (New York, N.Y.) 1981;213(4513):1282.
1981: A Ettenberg; George F Koob; F E Bloom
Response artifact in the measurement of neuroleptic-induced anhedonia.
Science (New York, N.Y.) 1981;213(4505):357-9.
1981: M Le Moal; George F Koob; L Y Koda; F E Bloom; M Manning; W H Sawyer; J Rivier
Vasopressor receptor antagonist prevents behavioural effects of vasopressin.
Nature 1981;291(5815):491-3.
1981: George F Koob; M Le Moal; O Gaffori; M Manning; W H Sawyer; J Rivier; F E Bloom
Arginine vasopressin and a vasopressin antagonist peptide: opposite effects on extinction of active avoidance in rats.
Regulatory peptides 1981;2(3):153-63.
1981: E M Joyce; George F Koob
Amphetamine-, scopolamine- and caffeine-induced locomotor activity following 6-hydroxydopamine lesions of the mesolimbic dopamine system.
Psychopharmacology 1981;73(4):311-3.
1980: Trevor W Robbins; George F Koob
Selective disruption of displacement behaviour by lesions of the mesolimbic dopamine system.
Nature 1980;285(5764):409-12.
1980: David Roberts; George F Koob; P Klonoff; H C Fibiger
Extinction and recovery of cocaine self-administration following 6-hydroxydopamine lesions of the nucleus accumbens.
Pharmacology, biochemistry, and behavior 1980;12(5):781-7.
1980: G R Sessions; J L Meyerhoff; GJ Kant; George F Koob
Effects of lesions of the ventral medial tegmentum on locomotor activity, biogenic amines and responses to amphetamine in rats.
Pharmacology, biochemistry, and behavior 1980;12(4):603-8.
1980: L Stinus; George F Koob; N Ling; F E Bloom; M Le Moal
Locomotor activation induced by infusion of endorphins into the ventral tegmental area: evidence for opiate-dopamine interactions.
Proceedings of the National Academy of Sciences of the United States of America 1980;77(4):2323-7.
1980: George F Koob; R E Strecker; F E Bloom
Effects of naloxone on the anticonflict properties of alcohol and chlordiazepoxide.
Substance and alcohol actions/misuse 1980;1(5-6):447-57.
1980: F Bloom; A Bayon; E Battenberg; E French; L Koda; George F Koob; M Le Moal; J Rossier; W Shoemaker
Endorphins: developmental, cellular, and behavioral aspects.
Advances in biochemical psychopharmacology 1980;22():619-32.
1980: P J Fray; Barbara J Sahakian; Trevor W Robbins; George F Koob; S D Iversen
An observational method for quantifying the behavioural effects of dopamine agonists: contrasting effects of d-amphetamine and apomorphine.
Psychopharmacology 1980;69(3):253-9.
1979: M Le Moal; George F Koob; F E Bloom
Endorphins and extinction: differential actions on appetitive and adversive tasks.
Life sciences 1979;24(18):1631-6.
1978: L Y Koda; George F Koob; W T Shier; F E Bloom
Tetrahydropapaveroline induces small granular vesicles in brain dopamine fibres.
Nature 1978;276(5685):281-3.
1978: George F Koob; S J Riley; S C Smith; Trevor W Robbins
Effects of 6-hydroxydopamine lesions of the nucleus accumbens septi and olfactory tubercle on feeding, locomotor activity, and amphetamine anorexia in the rat.
Journal of comparative and physiological psychology 1978;92(5):917-27.
1978: George F Koob; A E Kelley; S T Mason
Locus coeruleus lesions: learning and extinction.
Physiology & behavior 1978;20(6):709-16.
1978: Barbara J Sahakian; George F Koob
The relationship between pipradrol-induced responding for electrical brain stimulation, stereotyped behaviour and locomotor activity.
Neuropharmacology 1978;17(6):363-6.
1978: George F Koob; M Del Fiacco; S D Iversen
Spontaneous and amphetamine-induced behavior after bilateral injection of ethanolamine-O-sulfate into the substantia nigra.
Brain research 1978;146(2):313-23.
1978: George F Koob; P J Fray; S D Iversen
Self-stimulation at the lateral hypothalamus and locus coeruleus after specific unilateral lesions of the dopamine system.
Brain research 1978;146(1):123-40.
1978: Trevor W Robbins; George F Koob
Pipradrol enhances reinforcing properties of stimuli paired with brain stimulation.
Pharmacology, biochemistry, and behavior 1978;8(3):219-22.
1978: P C Emson; George F Koob
The origin and distribution of dopamine-containing afferents to the rat frontal cortex.
Brain research 1978;142(2):249-67.
1977: George F Koob; Gail Winger; J L Meyerhoff; Z Annau
Effects of D-amphetamine on concurrent self-stimulation of forebrain and brain stem loci.
Brain research 1977;137(1):109-26.
1977: P C Emson; George F Koob; L L Iversen
Origin of dopaminergic afferents to the rat frontal cortex [proceedings].
British journal of pharmacology 1977;60(2):270P-271P.
1977: George F Koob; M Del Fiacco; S D Iversen
Dissociable properties of dopamine neurons im the nigrostriatal and mesolimbic dopamine systems.
Advances in biochemical psychopharmacology 1977;16():589-95.
1977: S D Iversen; George F Koob
Behavioral implications of dopaminergic neurons in the mesolimbic system.
Advances in biochemical psychopharmacology 1977;16():209-14.
1977: George F Koob
Incentive shifts in intracranial self-stimulation produced by different series of stimulus intensity presentations.
Physiology & behavior 1977;18(1):131-5.
1976: George F Koob; P J Fray; S D Iversen
Tail-pinch stimulation: sufficient motivation for learning.
Science (New York, N.Y.) 1976;194(4265):637-9.
1976: George F Koob; G R Sessions; G J Kant; J L Meyerhoff
Dissociation of hyperdipsia from the destruction of the locus coeruleus in rats.
Brain research 1976;116(2):339-45.
1976: G R Sessions; G J Kant; George F Koob
Locus coeruleus lesions and learning in the rat.
Physiology & behavior 1976;17(5):853-9.
1976: George F Koob; M del Fiacco; S D Iversen
The behavioural effects of EOS-induced changes in substantia nigra GABA levels [proceedings].
British journal of pharmacology 1976;58(3):454P.
1976: George F Koob; G J Balcom; J L Meyerhoff
Increases in intracranial self-stimulation in the posterior hypothalamus following unilateral lesions in the locus coeruleus.
Brain research 1976;101(3):554-60.
1975: George F Koob; G J Balcom; J L Meyerhoff
Dopamine and norepinephrine levels in the nucleus accumbens, olfactory tubercle and corpus striatum following lesions in the ventral tegmentalarea.
Brain research 1975;94(1):45-55.
1975: George F Koob; N H Spector; J L Meyerhoff
Effects of heroin on lever pressing for intracranial self-stimulation, food and water in the rat.
Psychopharmacologia 1975;42(3):231-4.
1974: Z Annau; R Heffner; George F Koob
Electrical self-stimulation of single and multiple loci: long term observations.
Physiology & behavior 1974;13(2):281-90.
1974: George F Koob; Z Annau
Behavioral and neurochemical alterations induced by hypoxia in rats.
The American journal of physiology 1974;227(1):73-8.
1974: George F Koob; Z Annau; R J Rubin; M R Montgomery
Effect of hypoxic hypoxia and carbon monoxide on food intake, water intake, and body weight in two strains of rats.
Life sciences 1974;14(8):1511-20.
1973: George F Koob; Z Annau
Effect of hypoxia on hypothalamic mechanisms.
The American journal of physiology 1973;224(6):1403-8.