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Eric Kool

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Chemicals & Drugs

Concepts & Ideas

Genes & Molecular Sequences

Molecular Structure

Phenomena

Physiology

DNA Replication

Procedures

Fluorescence Spectrometry

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Network (preview)

Co-Publications
Name
11
Gao, Jianmin
11
Silverman, Adam
10
Liu, Haibo
7
Miller, Gregory
6
Wilson, James
5
Krueger, Andrew
5
Lu, Haige
5
Lee, Alex
5
Kim, Tae Woo
5
Abe, Hiroshi
4
Lynch, Stephen
4
Teo, Yin Nah
3
Lai, Jacob
3
Sando, Shinsuke
3
Sintim, Herman

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Publications

TOP 3
Franzini Raphael M; Kool Eric T
Efficient nucleic acid detection by templated reductive quencher release.
Teo Yin Nah; Wilson James N; Kool Eric T
Polyfluorophore labels on DNA: dramatic sequence dependence of quenching.
Lu Haige; Lynch Stephen R; Lee Alex H F; Kool Eric T
Structure and replication of yDNA: a novel genetic set widened by benzo-homologation.

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All Publications

2009: Franzini Raphael M; Kool Eric T
Efficient nucleic acid detection by templated reductive quencher release.
Journal of the American Chemical Society 2009;131(44):16021-3.
2009: Teo Yin Nah; Wilson James N; Kool Eric T
Polyfluorophore labels on DNA: dramatic sequence dependence of quenching.
Chemistry (Weinheim an der Bergstrasse, Germany) 2009;15(43):11551-8.
2009: Lu Haige; Lynch Stephen R; Lee Alex H F; Kool Eric T
Structure and replication of yDNA: a novel genetic set widened by benzo-homologation.
Chembiochem : a European journal of chemical biology 2009;10(15):2530-8.
2009: Krueger Andrew T; Kool Eric T
Redesigning the architecture of the base pair: toward biochemical and biological function of new genetic sets.
Chemistry & biology 2009;16(3):242-8.
2009: Teo Yin Nah; Wilson James N; Kool Eric T
Polyfluorophores on a DNA backbone: a multicolor set of labels excited at one wavelength.
Journal of the American Chemical Society 2009;131(11):3923-33.
2009: Terrazas Montserrat; Kool Eric T
RNA major groove modifications improve siRNA stability and biological activity.
Nucleic acids research 2009;37(2):346-53.
2009: Delaney James C; Gao Jianmin; Liu Haibo; Shrivastav Nidhi; Essigmann John M; Kool Eric T
Efficient replication bypass of size-expanded DNA base pairs in bacterial cells.
Angewandte Chemie (International ed. in English) 2009;48(25):4524-7.
2008: Lee Harold R; Helquist Sandra A; Kool Eric T; Johnson Kenneth A
Base pair hydrogen bonds are essential for proofreading selectivity by the human mitochondrial DNA polymerase.
The Journal of biological chemistry 2008;283(21):14411-6.
2008: Lee Harold R; Helquist Sandra A; Kool Eric T; Johnson Kenneth A
Importance of hydrogen bonding for efficiency and specificity of the human mitochondrial DNA polymerase.
The Journal of biological chemistry 2008;283(21):14402-10.
2008: Silverman Adam P; Garforth Scott J; Prasad Vinayaka R; Kool Eric T
Probing the active site steric flexibility of HIV-1 reverse transcriptase: different constraints for DNA- versus RNA-templated synthesis.
Biochemistry 2008;47(16):4800-7.
2008: Krueger Andrew T; Kool Eric T
Fluorescence of size-expanded DNA bases: reporting on DNA sequence and structure with an unnatural genetic set.
Journal of the American Chemical Society 2008;130(12):3989-99.
2008: Wilson James N; Cho Younjin; Tan Samuel; Cuppoletti Andrea; Kool Eric T
Quenching of fluorescent nucleobases by neighboring DNA: the "insulator" concept.
Chembiochem : a European journal of chemical biology 2008;9(2):279-85.
2008: Miller Gregory P; Silverman Adam P; Kool Eric T
New, stronger nucleophiles for nucleic acid-templated chemistry: Synthesis and application in fluorescence detection of cellular RNA.
Bioorganic & medicinal chemistry 2008;16(1):56-64.
2008: Krueger Andrew T; Lu Haige; Højland Torben; Liu Haibo; Gao Jianmin; Kool Eric T
Towards the replication of xDNA, a size-expanded unnatural genetic system.
Nucleic acids symposium series (2004) 2008;(52):455-6.
2008: Teo Yin Nah; Kool Eric T
Studies of oligodeoxyfluorosides (ODFs) as FRET probes for DNA hybridization.
Nucleic acids symposium series (2004) 2008;(52):233-4.
2008: Silverman Adam P; Abe Hiroshi; Kool Eric T
Quenched autoligation probes.
Methods in molecular biology (Clifton, N.J.) 2008;429():161-70.
2008: Somoza Alvaro; Silverman Adam P; Miller Rand M; Chelliserrykattil Jijumon; Kool Eric T
Steric effects in RNA interference: probing the influence of nucleobase size and shape.
Chemistry (Weinheim an der Bergstrasse, Germany) 2008;14(26):7978-87.
2007: Wilson James N; Teo Yin Nah; Kool Eric T
Efficient quenching of oligomeric fluorophores on a DNA backbone.
Journal of the American Chemical Society 2007;129(50):15426-7.
2007: Silverman Adam P; Jiang Qingfei; Goodman Myron F; Kool Eric T
Steric and electrostatic effects in DNA synthesis by the SOS-induced DNA polymerases II and IV of Escherichia coli.
Biochemistry 2007;46(48):13874-81.
2007: Krueger Andrew T; Kool Eric T
Model systems for understanding DNA base pairing.
Current opinion in chemical biology 2007;11(6):588-94.
2007: Silverman Adam P; Kool Eric T
RNA probes of steric effects in active sites: high flexibility of HIV-1 reverse transcriptase.
Journal of the American Chemical Society 2007;129(35):10626-7.
2007: Taniguchi Yosuke; Kool Eric T
Nonpolar isosteres of damaged DNA bases: effective mimicry of mutagenic properties of 8-oxopurines.
Journal of the American Chemical Society 2007;129(28):8836-44.
2007: Krueger Andrew T; Lu Haige; Lee Alex H F; Kool Eric T
Synthesis and properties of size-expanded DNAs: toward designed, functional genetic systems.
Accounts of chemical research 2007;40(2):141-50.
2007: Kool Eric T; Waters Marcey L
The model student: what chemical model systems can teach us about biology.
Nature chemical biology 2007;3(2):70-3.
2007: Taniguchi Yosuke; Kool Eric T
Syntheses and properties of low-polarity shape mimics of 8-oxopurines.
Nucleic acids symposium series (2004) 2007;(51):217-8.
2007: Silverman Adam P; Kool Eric T
Oligonucleotide probes for RNA-targeted fluorescence in situ hybridization.
Advances in clinical chemistry 2007;43():79-115.
2006: Wilson James N; Kool Eric T
Fluorescent DNA base replacements: Reporters and sensors for biological systems.
Organic & biomolecular chemistry 2006;4(23):4265-74.
2006: Silverman Adam P; Baron Ellen J; Kool Eric T
RNA-templated chemistry in cells: discrimination of Escherichia, Shigella and Salmonella bacterial strains with a new two-color FRET strategy.
Chembiochem : a European journal of chemical biology 2006;7(12):1890-4.
2006: Lynch Stephen R; Liu Haibo; Gao Jianmin; Kool Eric T
Toward a designed, functioning genetic system with expanded-size base pairs: solution structure of the eight-base xDNA double helix.
Journal of the American Chemical Society 2006;128(45):14704-11.
2006: Kool Eric T; Sintim Herman O
The difluorotoluene debate--a decade later.
Chemical communications (Cambridge, England) 2006;(35):3665-75.
2006: Silverman Adam P; Kool Eric T
Detecting RNA and DNA with templated chemical reactions.
Chemical reviews 2006;106(9):3775-89.
2006: Lee Alex H F; Kool Eric T
Exploring the limits of DNA size: naphtho-homologated DNA bases and pairs.
Journal of the American Chemical Society 2006;128(28):9219-30.
2006: Somoza Alvaro; Chelliserrykattil Jijumon; Kool Eric T
The roles of hydrogen bonding and sterics in RNA interference.
Angewandte Chemie (International ed. in English) 2006;45(30):4994-7.
2006: Kim Su Jeong; Kool Eric T
Sensing metal ions with DNA building blocks: fluorescent pyridobenzimidazole nucleosides.
Journal of the American Chemical Society 2006;128(18):6164-71.
2006: Cho Younjin; Kool Eric T
Enzymatic synthesis of fluorescent oligomers assembled on a DNA backbone.
Chembiochem : a European journal of chemical biology 2006;7(4):669-72.
2006: Sintim Herman O; Kool Eric T
Remarkable sensitivity to DNA base shape in the DNA polymerase active site.
Angewandte Chemie (International ed. in English) 2006;45(12):1974-9.
2006: Mizukami Shin; Kim Tae Woo; Helquist Sandra A; Kool Eric T
Varying DNA base-pair size in subangstrom increments: evidence for a loose, not large, active site in low-fidelity Dpo4 polymerase.
Biochemistry 2006;45(9):2772-8.
2006: Sintim Herman O; Kool Eric T
Enhanced base pairing and replication efficiency of thiothymidines, expanded-size variants of thymidine.
Journal of the American Chemical Society 2006;128(2):396-7.
2006: Abe Hiroshi; Kool Eric T
Flow cytometric detection of specific RNAs in native human cells with quenched autoligating FRET probes.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(2):263-8.
2006: Kim Tae Woo; Brieba Luis G; Ellenberger Tom; Kool Eric T
Functional evidence for a small and rigid active site in a high fidelity DNA polymerase: probing T7 DNA polymerase with variably sized base pairs.
The Journal of biological chemistry 2006;281(4):2289-95.
2006: Kool Eric T; Lu Haige; Kim Su Jeong; Tan Samuel; Wilson James N; Gao Jianmin; Liu Haibo
New designs for DNA bases: expanded DNAs and oligofluorosides.
Nucleic acids symposium series (2004) 2006;(50):15-6.
2005: Kim Tae Woo; Delaney James C; Essigmann John M; Kool Eric T
Probing the active site tightness of DNA polymerase in subangstrom increments.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(44):15803-8.
2005: Hartig Jörg S; Fernandez-Lopez Sara; Kool Eric T
Guanine-rich DNA nanocircles for the synthesis and characterization of long cytosine-rich telomeric DNAs.
Chembiochem : a European journal of chemical biology 2005;6(8):1458-62.
2005: Devaraj Neal K; Miller Gregory P; Ebina Wataru; Kakaradov Boyko; Collman James P; Kool Eric T; Chidsey Christopher E D
Chemoselective covalent coupling of oligonucleotide probes to self-assembled monolayers.
Journal of the American Chemical Society 2005;127(24):8600-1.
2005: Cuppoletti Andrea; Cho Younjin; Park Jin-Seong; Strässler Christoph; Kool Eric T
Oligomeric fluorescent labels for DNA.
Bioconjugate chemistry 2005;16(3):528-34.
2005: Silverman Adam P; Kool Eric T
Quenched probes for highly specific detection of cellular RNAs.
Trends in biotechnology 2005;23(5):225-30.
2005: Gao Jianmin; Liu Haibo; Kool Eric T
Assembly of the complete eight-base artificial genetic helix, xDNA, and its interaction with the natural genetic system.
Angewandte Chemie (International ed. in English) 2005;44(20):3118-22.
2005: Lai Jacob S; Kool Eric T
Fluorous base-pairing effects in a DNA polymerase active site.
Chemistry (Weinheim an der Bergstrasse, Germany) 2005;11(10):2966-71.
2005: Kim Tae Woo; Kool Eric T
A series of nonpolar thymidine analogues of increasing size: DNA base pairing and stacking properties.
The Journal of organic chemistry 2005;70(6):2048-53.
2005: Lee Alex H F; Kool Eric T
A new four-base genetic helix, yDNA, composed of widened benzopyrimidine-purine pairs.
Journal of the American Chemical Society 2005;127(10):3332-8.
2005: Liu Haibo; Gao Jianmin; Kool Eric T
Helix-forming properties of size-expanded DNA, an alternative four-base genetic form.
Journal of the American Chemical Society 2005;127(5):1396-402.
2005: Yoshina-Ishii Chiaki; Miller Gregory P; Kraft Mary L; Kool Eric T; Boxer Steven G
General method for modification of liposomes for encoded assembly on supported bilayers.
Journal of the American Chemical Society 2005;127(5):1356-7.
2005: Liu Haibo; Gao Jianmin; Kool Eric T
Size-expanded analogues of dG and dC: synthesis and pairing properties in DNA.
The Journal of organic chemistry 2005;70(2):639-47.
2005: Lee Alex H F; Kool Eric T
Novel benzopyrimidines as widened analogues of DNA bases.
The Journal of organic chemistry 2005;70(1):132-40.
2005: Abe Hiroshi; Kool Eric T
Universal linkers for signal amplification in auto-ligating probes.
Nucleic acids symposium series (2004) 2005;(49):37-8.
2005: Silverman Adam P; Kool Eric T
Quenched autoligation probes allow discrimination of live bacterial species by single nucleotide differences in rRNA.
Nucleic acids research 2005;33(15):4978-86.
2005: Hartig Jörg S; Kool Eric T
Efficient isothermal expansion of human telomeric and minisatellite repeats by Thermococcus litoralis DNA polymerase.
Nucleic acids research 2005;33(15):4922-7.
2004: Lu Haige; He Kaizhang; Kool Eric T
yDNA: a new geometry for size-expanded base pairs.
Angewandte Chemie (International ed. in English) 2004;43(43):5834-6.
2004: Abe Hiroshi; Kool Eric T
Destabilizing universal linkers for signal amplification in self-ligating probes for RNA.
Journal of the American Chemical Society 2004;126(43):13980-6.
2004: Kim Tae Woo; Kool Eric T
A set of nonpolar thymidine nucleoside analogues with gradually increasing size.
Organic letters 2004;6(22):3949-52.
2004: Gao Jianmin; Watanabe Soichiro; Kool Eric T
Modified DNA analogues that sense light exposure with color changes.
Journal of the American Chemical Society 2004;126(40):12748-9.
2004: Gao Jianmin; Liu Haibo; Kool Eric T
Expanded-size bases in naturally sized DNA: evaluation of steric effects in Watson-Crick pairing.
Journal of the American Chemical Society 2004;126(38):11826-31.
2004: Liu Haibo; Lynch Stephen R; Kool Eric T
Solution structure of xDNA: a paired genetic helix with increased diameter.
Journal of the American Chemical Society 2004;126(22):6900-5.
2004: Miller Gregory P; Kool Eric T
Versatile 5'-functionalization of oligonucleotides on solid support: amines, azides, thiols, and thioethers via phosphorus chemistry.
The Journal of organic chemistry 2004;69(7):2404-10.
2004: Lai Jacob S; Kool Eric T
Selective pairing of polyfluorinated DNA bases.
Journal of the American Chemical Society 2004;126(10):3040-1.
2004: Liu Haibo; Gao Jianmin; Maynard Lystranne; Saito Y David; Kool Eric T
Toward a new genetic system with expanded dimensions: size-expanded analogues of deoxyadenosine and thymidine.
Journal of the American Chemical Society 2004;126(4):1102-9.
2004: Sando Shinsuke; Abe Hiroshi; Kool Eric T
Quenched auto-ligating DNAs: multicolor identification of nucleic acids at single nucleotide resolution.
Journal of the American Chemical Society 2004;126(4):1081-7.
2004: Maki Angèle S; Kim TaeWoo; Kool Eric T
Direct comparison of A- and T-strand minor groove interactions in DNA curvature at A tracts.
Biochemistry 2004;43(4):1102-10.
2004: Smietana Michael; Johnson Robert B; Wang Q May; Kool Eric T
Solid-phase synthesis and screening of macrocyclic nucleotide-hybrid compounds targeted to hepatitis C NS5B.
Chemistry (Weinheim an der Bergstrasse, Germany) 2004;10(1):173-81.
2004: Hartig Jörg S; Kool Eric T
Small circular DNAs for synthesis of the human telomere repeat: varied sizes, structures and telomere-encoding activities.
Nucleic acids research 2004;32(19):e152.
2003: Lai Jacob S; Qu Jin; Kool Eric T
Fluorinated DNA bases as probes of electrostatic effects in DNA base stacking.
Angewandte Chemie (International ed. in English) 2003;42(48):5973-7.
2003: Kool Eric T; Miller Gregory P
5'-Iodination of solid-phase-linked oligodeoxyribonucleotides.
Current protocols in nucleic acid chemistry / edited by Serge L. Beaucage ... [et al.] 2003;Chapter 4():Unit 4.19.
2003: Liu Haibo; Gao Jianmin; Lynch Stephen R; Saito Y David; Maynard Lystranne; Kool Eric T
A four-base paired genetic helix with expanded size.
Science (New York, N.Y.) 2003;302(5646):868-71.
2003: Delaney James C; Henderson Paul T; Helquist Sandra A; Morales Juan C; Essigmann John M; Kool Eric T
High-fidelity in vivo replication of DNA base shape mimics without Watson-Crick hydrogen bonds.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(8):4469-73.
2003: Maki Angèle; Brownewell Floyd E; Liu Dongyu; Kool Eric T
DNA curvature at A tracts containing a non-polar thymine mimic.
Nucleic acids research 2003;31(3):1059-66.
2002: Morales-Rojas Hugo; Kool Eric T
A porphyrin C-nucleoside incorporated into DNA.
Organic letters 2002;4(25):4377-80.
2002: Lindstrom Ulf M; Chandrasekaran Ravi A; Orbai Lucian; Helquist Sandra A; Miller Gregory P; Oroudjev Emin; Hansma Helen G; Kool Eric T
Artificial human telomeres from DNA nanocircle templates.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(25):15953-8.
2002: Kool Eric T
Replacing the nucleobases in DNA with designer molecules.
Accounts of chemical research 2002;35(11):936-43.
2002: Miller Gregory P; Kool Eric T
A simple method for electrophilic functionalization of DNA.
Organic letters 2002;4(21):3599-601.
2002: Smietana Michael; Kool Eric T
Efficient and simple solid-phase synthesis of short cyclic oligodeoxynucleotides bearing a phosphorothioate linkage.
Angewandte Chemie (International ed. in English) 2002;41(19):3704-7; 3523.
2002: Lindström Ulf M; Kool Eric T
An orthogonal oligonucleotide protecting group strategy that enables assembly of repetitive or highly structured DNAs.
Nucleic acids research 2002;30(19):e101.
2002: Gao Jianmin; Strässler Christoph; Tahmassebi Deborah; Kool Eric T
Libraries of composite polyfluors built from fluorescent deoxyribosides.
Journal of the American Chemical Society 2002;124(39):11590-1.
2002: Sando Shinsuke; Kool Eric T
Imaging of RNA in bacteria with self-ligating quenched probes.
Journal of the American Chemical Society 2002;124(33):9686-7.
2002: Drotschmann Karin; Hall Mark C; Shcherbakova Polina V; Wang Hong; Erie Dorothy A; Brownewell Floyd R; Kool Eric T; Kunkel Thomas A
DNA binding properties of the yeast Msh2-Msh6 and Mlh1-Pms1 heterodimers.
Biological chemistry 2002;383(6):969-75.
2002: Sando Shinsuke; Kool Eric T
Quencher as leaving group: efficient detection of DNA-joining reactions.
Journal of the American Chemical Society 2002;124(10):2096-7.
2002: Kool Eric T
Active site tightness and substrate fit in DNA replication.
Annual review of biochemistry 2002;71():191-219.
2001: Drotschmann K; Yang W; Brownewell F E; Kool E T; Kunkel T A
Asymmetric recognition of DNA local distortion. Structure-based functional studies of eukaryotic Msh2-Msh6.
The Journal of biological chemistry 2001;276(49):46225-9.
2001: Schofield M J; Brownewell F E; Nayak S; Du C; Kool E T; Hsieh P
The Phe-X-Glu DNA binding motif of MutS. The role of hydrogen bonding in mismatch recognition.
The Journal of biological chemistry 2001;276(49):45505-8.
2000: Kool E T
Synthetically modified DNAs as substrates for polymerases.
Current opinion in chemical biology 2000;4(6):602-8.
2000: Kool E T
Roles of Watson-Crick and minor groove hydrogen bonds in DNA replication.
Cold Spring Harbor symposia on quantitative biology 2000;65():93-102.

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