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Jindrich Kopecek

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Huaizhong Pan; Jiyuan Yang; Pavla Kopecková; Jindrich Kopecek
Backbone degradable multiblock N-(2-hydroxypropyl)methacrylamide copolymer conjugates via reversible addition-fragmentation chain transfer polymerization and thiol-ene coupling reaction.
Kristina Giantsos-Adams; Veronica Lopez-Quintero; Pavla Kopeckova; Jindrich Kopecek; John M Tarbell; Randal O Dull
Study of the therapeutic benefit of cationic copolymer administration to vascular endothelium under mechanical stress.
Jindrich Kopecek
Biomaterials and drug delivery: past, present, and future.

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2011: Huaizhong Pan; Jiyuan Yang; Pavla Kopecková; Jindrich Kopecek
Backbone degradable multiblock N-(2-hydroxypropyl)methacrylamide copolymer conjugates via reversible addition-fragmentation chain transfer polymerization and thiol-ene coupling reaction.
Biomacromolecules 2011;12(1):247-52.
2011: Kristina Giantsos-Adams; Veronica Lopez-Quintero; Pavla Kopeckova; Jindrich Kopecek; John M Tarbell; Randal O Dull
Study of the therapeutic benefit of cationic copolymer administration to vascular endothelium under mechanical stress.
Biomaterials 2011;32(1):288-94.
2010: Jindrich Kopecek
Biomaterials and drug delivery: past, present, and future.
Molecular pharmaceutics 2010;7(4):922-5.
2010: Jiyuan Yang; Michael T Jacobsen; Huaizhong Pan; Jindrich Kopecek
Synthesis and characterization of enzymatically degradable PEG-based peptide-containing hydrogels.
Macromolecular bioscience 2010;10(4):445-54.
2010: Jihua Liu; Hillevi Bauer; Jon Callahan; Pavla Kopecková; Huaizhong Pan; Jindrich Kopecek
Endocytic uptake of a large array of HPMA copolymers: Elucidation into the dependence on the physicochemical characteristics.
Journal of controlled release : official journal of the Controlled Release Society 2010;143(1):71-9.
2010: Jindrich Kopecek; Pavla Kopecková
HPMA copolymers: origins, early developments, present, and future.
Advanced drug delivery reviews 2010;62(2):122-49.
2010: Kuangshi Wu; Jihua Liu; Russell N Johnson; Jiyuan Yang; Jindrich Kopecek
Drug-free macromolecular therapeutics: induction of apoptosis by coiled-coil-mediated cross-linking of antigens on the cell surface.
Angewandte Chemie (International ed. in English) 2010;49(8):1451-5.
2009: Song-Qi Gao; Yongen Sun; Pavla Kopecková; C Matthew Peterson; Jindrich Kopecek
Antitumor efficacy of colon-specific HPMA copolymer/9-aminocamptothecin conjugates in mice bearing human-colon carcinoma xenografts.
Macromolecular bioscience 2009;9(11):1135-42.
2009: Larisa C Radu-Wu; Jiyuan Yang; Kuangshi Wu; Jindrich Kopecek
Self-assembled hydrogels from poly[N-(2-hydroxypropyl)methacrylamide] grafted with beta-sheet peptides.
Biomacromolecules 2009;10(8):2319-27.
2009: Jihua Liu; Pavla Kopecková; Patrick Bühler; Philipp Wolf; Huaizhong Pan; Hillevi Bauer; Ursula Elsässer-Beile; Jindrich Kopecek
Biorecognition and subcellular trafficking of HPMA copolymer-anti-PSMA antibody conjugates by prostate cancer cells.
Molecular pharmaceutics 2009;6(3):959-70.
2009: Jindrich Kopecek; Jiyuan Yang
Peptide-directed self-assembly of hydrogels.
Acta biomaterialia 2009;5(3):805-16.
2009: Larisa Cristina Radu; Jiyuan Yang; Jindrich Kopecek
Self-assembling diblock copolymers of poly[N-(2-hydroxypropyl)methacrylamide] and a beta-sheet peptide.
Macromolecular bioscience 2009;9(1):36-44.
2009: Ehud Segal; Huaizhong Pan; Paula Ofek; Taturo Udagawa; Pavla Kopecková; Jindrich Kopecek; Ronit Satchi-Fainaro
Targeting angiogenesis-dependent calcified neoplasms using combined polymer therapeutics.
PloS one 2009;4(4):e5233.
2009: Russell N Johnson; Pavla Kopecková; Jindrich Kopecek
Synthesis and evaluation of multivalent branched HPMA copolymer-Fab' conjugates targeted to the B-cell antigen CD20.
Bioconjugate chemistry 2009;20(1):129-37.
2008: Scott C Miller; H Pan; Dong Wang; Beth M Bowman; Pavla Kopecková; Jindrich Kopecek
Feasibility of using a bone-targeted, macromolecular delivery system coupled with prostaglandin E(1) to promote bone formation in aged, estrogen-deficient rats.
Pharmaceutical research 2008;25(12):2889-95.
2008: Weiwei Yuan; Jiyuan Yang; Pavla Kopecková; Jindrich Kopecek
Smart hydrogels containing adenylate kinase: translating substrate recognition into macroscopic motion.
Journal of the American Chemical Society 2008;130(47):15760-1.
2008: Vaikunth Cuchelkar; Pavla Kopecková; Jindrich Kopecek
Novel HPMA copolymer-bound constructs for combined tumor and mitochondrial targeting.
Molecular pharmaceutics 2008;5(5):776-86.
2008: Jarunee Hongrapipat; Pavla Kopecková; Jihua Liu; Sompol Prakongpan; Jindrich Kopecek
Combination chemotherapy and photodynamic therapy with fab' fragment targeted HPMA copolymer conjugates in human ovarian carcinoma cells.
Molecular pharmaceutics 2008;5(5):696-709.
2008: Huaizhong Pan; Jihua Liu; Yuanyi Dong; Monika Sima; Pavla Kopecková; Maria Luisa Brandi; Jindrich Kopecek
Release of prostaglandin E(1) from N-(2-hydroxypropyl)methacrylamide copolymer conjugates by bone cells.
Macromolecular bioscience 2008;8(7):599-605.
2008: Huaizhong Pan; Monika Sima; Pavla Kopecková; Kuangshi Wu; Songqi Gao; Jihua Liu; Dong Wang; Scott C Miller; Jindrich Kopecek
Biodistribution and pharmacokinetic studies of bone-targeting N-(2-hydroxypropyl)methacrylamide copolymer-alendronate conjugates.
Molecular pharmaceutics 2008;5(4):548-58.
2008: Vaikunth Cuchelkar; Pavla Kopecková; Jindrich Kopecek
Synthesis and biological evaluation of disulfide-linked HPMA copolymer-mesochlorin e6 conjugates.
Macromolecular bioscience 2008;8(5):375-83.
2008: J Hongrapipat; Pavla Kopecková; Sompol Prakongpan; Jindrich Kopecek
Enhanced antitumor activity of combinations of free and HPMA copolymer-bound drugs.
International journal of pharmaceutics 2008;351(1-2):259-70.
2008: Chunyu Xu; Jindrich Kopecek
Genetically engineered block copolymers: influence of the length and structure of the coiled-coil blocks on hydrogel self-assembly.
Pharmaceutical research 2008;25(3):674-82.
2008: Jiyuan Yang; Kuangshi Wu; Cestmír Konák; Jindrich Kopecek
Dynamic light scattering study of self-assembly of HPMA hybrid graft copolymers.
Biomacromolecules 2008;9(2):510-7.
2008: Song-Qi Gao; Yongen Sun; Pavla Kopecková; C Matthew Peterson; Jindrich Kopecek
Pharmacokinetic modeling of absorption behavior of 9-aminocamptothecin (9-AC) released from colon-specific HPMA copolymer-9-AC conjugate in rats.
Pharmaceutical research 2008;25(1):218-26.
2007: Alexander Malugin; Pavla Kopecková; Jindrich Kopecek
Liberation of doxorubicin from HPMA copolymer conjugate is essential for the induction of cell cycle arrest and nuclear fragmentation in ovarian carcinoma cells.
Journal of controlled release : official journal of the Controlled Release Society 2007;124(1-2):6-10.
2007: Huaizhong Pan; Pavla Kopecková; Jihua Liu; Dong Wang; Scott C Miller; Jindrich Kopecek
Stability in plasmas of various species of HPMA copolymer-PGE1 conjugates.
Pharmaceutical research 2007;24(12):2270-80.
2007: Jindrich Kopecek
Hydrogel biomaterials: a smart future?
Biomaterials 2007;28(34):5185-92.
2007: Dong Wang; Scott C Miller; Luda S Shlyakhtenko; Alexander M Portillo; Xin-Ming Liu; Kongnara Papangkorn; Pavla Kopecková; Yuri L Lyubchenko; William I Higuchi; Jindrich Kopecek
Osteotropic Peptide that differentiates functional domains of the skeleton.
Bioconjugate chemistry 2007;18(5):1375-8.
2007: Hui Ding; Pavla Kopecková; Jindrich Kopecek
Self-association properties of HPMA copolymers containing an amphipathic heptapeptide.
Journal of drug targeting 2007;15(7-8):465-74.
2007: Song-Qi Gao; Zheng-Rong Lu; Pavla Kopecková; Jindrich Kopecek
Biodistribution and pharmacokinetics of colon-specific HPMA copolymer--9-aminocamptothecin conjugate in mice.
Journal of controlled release : official journal of the Controlled Release Society 2007;117(2):179-85.
2006: Dong Wang; Monika Sima; R Lee Mosley; Jasmine P Davda; Nicole Tietze; Scott C Miller; Peter R Gwilt; Pavla Kopecková; Jindrich Kopecek
Pharmacokinetic and biodistribution studies of a bone-targeting drug delivery system based on N-(2-hydroxypropyl)methacrylamide copolymers.
Molecular pharmaceutics 2006;3(6):717-25.
2006: Hui Ding; Wolfgang M Prodinger; Jindrich Kopecek
Two-step fluorescence screening of CD21-binding peptides with one-bead one-compound library and investigation of binding properties of N-(2-hydroxypropyl)methacrylamide copolymer-peptide conjugates.
Biomacromolecules 2006;7(11):3037-46.
2006: Jon Callahan; Jindrich Kopecek
Semitelechelic HPMA copolymers functionalized with triphenylphosphonium as drug carriers for membrane transduction and mitochondrial localization.
Biomacromolecules 2006;7(8):2347-56.
2006: Huaizhong Pan; Pavla Kopecková; Dong Wang; Jiyuan Yang; Scott Miller; Jindrich Kopecek
Water-soluble HPMA copolymer--prostaglandin E1 conjugates containing a cathepsin K sensitive spacer.
Journal of drug targeting 2006;14(6):425-35.
2006: Alexander Malugin; Pavla Kopecková; Jindrich Kopecek
HPMA copolymer-bound doxorubicin induces apoptosis in ovarian carcinoma cells by the disruption of mitochondrial function.
Molecular pharmaceutics 2006;3(3):351-61.
2006: Jiyuan Yang; Chunyu Xu; Chun Wang; Jindrich Kopecek
Refolding hydrogels self-assembled from N-(2-hydroxypropyl)methacrylamide graft copolymers by antiparallel coiled-coil formation.
Biomacromolecules 2006;7(4):1187-95.
2006: Jiyuan Yang; Chunyu Xu; Pavla Kopecková; Jindrich Kopecek
Hybrid hydrogels self-assembled from HPMA copolymers containing peptide grafts.
Macromolecular bioscience 2006;6(3):201-9.
2006: Hui Ding; Wolfgang M Prodinger; Jindrich Kopecek
Identification of CD21-binding peptides with phage display and investigation of binding properties of HPMA copolymer-peptide conjugates.
Bioconjugate chemistry 2006;17(2):514-23.
2006: Padmanabh Chivukula; Karel Dusek; Dong Wang; Mirka Dusková-Smrcková; Pavla Kopecková; Jindrich Kopecek
Synthesis and characterization of novel aromatic azo bond-containing pH-sensitive and hydrolytically cleavable IPN hydrogels.
Biomaterials 2006;27(7):1140-51.
2006: Song-Qi Gao; Zheng-Rong Lu; Boris Petri; Pavla Kopecková; Jindrich Kopecek
Colon-specific 9-aminocamptothecin-HPMA copolymer conjugates containing a 1,6-elimination spacer.
Journal of controlled release : official journal of the Controlled Release Society 2006;110(2):323-31.
2005: Thomas Merdan; Klaus Kunath; Holger Petersen; Udo Bakowsky; Karlheinz Voigt; Jindrich Kopecek; Thomas Kissel
PEGylation of poly(ethylene imine) affects stability of complexes with plasmid DNA under in vivo conditions in a dose-dependent manner after intravenous injection into mice.
Bioconjugate chemistry 2005;16(4):785-92.
2005: Dong Wang; Scott C Miller; Pavla Kopecková; Jindrich Kopecek
Bone-targeting macromolecular therapeutics.
Advanced drug delivery reviews 2005;57(7):1049-76.
2005: Dong Wang; Scott C Miller; Jindrich Kopecek
Targeted drug delivery for musculoskeletal diseases.
Advanced drug delivery reviews 2005;57(7):935-7.
2005: Chunyu Xu; Victor Breedveld; Jindrich Kopecek
Reversible hydrogels from self-assembling genetically engineered protein block copolymers.
Biomacromolecules 2005;6(3):1739-49.
2005: Aparna Nori; Jindrich Kopecek
Intracellular targeting of polymer-bound drugs for cancer chemotherapy.
Advanced drug delivery reviews 2005;57(4):609-36.
2005: Robyn M Hyde; Keith Jensen; Jindrich Kopecek; Arthur D Broom
Confocal microscopy studies of a model oligoribonucleotide HIV inhibitor.
Nucleosides, nucleotides & nucleic acids 2005;24(10-12):1875-84.
2005: Scott C Miller; Dong Wang; Pavla Kopecková; Jindrich Kopecek
Biopolymer-based delivery systems for advanced imaging and skeletal tissue-specific therapeutics.
Journal of bone and mineral metabolism 2005;23 Suppl():103-8.
2004: Peter D Senter; Jindrich Kopecek
Drug carriers in medicine and biology.
Molecular pharmaceutics 2004;1(6):395-8.
2004: Dong Wang; Scott C Miller; Monika Sima; Dennis Parker; Henry R Buswell; K Craig Goodrich; Pavla Kopecková; Jindrich Kopecek
The arthrotropism of macromolecules in adjuvant-induced arthritis rat model: a preliminary study.
Pharmaceutical research 2004;21(10):1741-9.
2004: Dong Wang; W Li; Michal Pechar; Pavla Kopecková; D Brömme; Jindrich Kopecek
Cathepsin K inhibitor-polymer conjugates: potential drugs for the treatment of osteoporosis and rheumatoid arthritis.
International journal of pharmaceutics 2004;277(1-2):73-9.
2004: Alexander Malugin; Pavla Kopecková; Jindrich Kopecek
HPMA copolymer-bound doxorubicin induces apoptosis in human ovarian carcinoma cells by a Fas-independent pathway.
Molecular pharmaceutics 2004;1(3):174-82.
2004: A David; Pavla Kopecková; Tamara Minko; Abraham Rubinstein; Jindrich Kopecek
Design of a multivalent galactoside ligand for selective targeting of HPMA copolymer-doxorubicin conjugates to human colon cancer cells.
European journal of cancer (Oxford, England : 1990) 2004;40(1):148-57.
2003: Nobuhiro Nishiyama; Aparna Nori; Alexander Malugin; Yuji Kasuya; Pavla Kopecková; Jindrich Kopecek
Free and N-(2-hydroxypropyl)methacrylamide copolymer-bound geldanamycin derivative induce different stress responses in A2780 human ovarian carcinoma cells.
Cancer research 2003;63(22):7876-82.
2003: Karel Dusek; Miroslava Dusková-Smrcková; Michal Ilavský; Russell Stewart; Jindrich Kopecek
Swelling pressure induced phase-volume transition in hybrid biopolymer gels caused by unfolding of folded crosslinks: a model.
Biomacromolecules 2003;4(6):1818-26.
2003: Jindrich Kopecek
Smart and genetically engineered biomaterials and drug delivery systems.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2003;20(1):1-16.
2003: Thomas Merdan; Jon Callahan; Holger Petersen; Klaus Kunath; Udo Bakowsky; Pavla Kopecková; Thomas Kissel; Jindrich Kopecek
Pegylated polyethylenimine-Fab' antibody fragment conjugates for targeted gene delivery to human ovarian carcinoma cells.
Bioconjugate chemistry 2003;14(5):989-96.
2003: Dong Wang; Scott Miller; Monika Sima; Pavla Kopecková; Jindrich Kopecek
Synthesis and evaluation of water-soluble polymeric bone-targeted drug delivery systems.
Bioconjugate chemistry 2003;14(5):853-9.
2003: Aparna Nori; Keith D Jensen; Monica Tijerina; Pavla Kopecková; Jindrich Kopecek
Subcellular trafficking of HPMA copolymer-Tat conjugates in human ovarian carcinoma cells.
Journal of controlled release : official journal of the Controlled Release Society 2003;91(1-2):53-9.
2003: Monica Tijerina; Pavla Kopecková; Jindrich Kopecek
Mechanisms of cytotoxicity in human ovarian carcinoma cells exposed to free Mce6 or HPMA copolymer-Mce6 conjugates.
Photochemistry and photobiology 2003;77(6):645-52.
2003: Monica Tijerina; Pavla Kopecková; Jindrich Kopecek
Correlation of subcellular compartmentalization of HPMA copolymer-Mce6 conjugates with chemotherapeutic activity in human ovarian carcinoma cells.
Pharmaceutical research 2003;20(5):728-37.
2003: Keith D Jensen; Aparna Nori; Monica Tijerina; Pavla Kopecková; Jindrich Kopecek
Cytoplasmic delivery and nuclear targeting of synthetic macromolecules.
Journal of controlled release : official journal of the Controlled Release Society 2003;87(1-3):89-105.
2003: C Matthew Peterson; Jane-Guo Shiah; Yongen Sun; Pavla Kopecková; Tamara Minko; Richard C Straight; Jindrich Kopecek
HPMA copolymer delivery of chemotherapy and photodynamic therapy in ovarian cancer.
Advances in experimental medicine and biology 2003;519():101-23.
2003: Aparna Nori; Keith D Jensen; Monica Tijerina; Pavla Kopecková; Jindrich Kopecek
Tat-conjugated synthetic macromolecules facilitate cytoplasmic drug delivery to human ovarian carcinoma cells.
Bioconjugate chemistry 2003;14(1):44-50.
2002: Thomas Merdan; Jindrich Kopecek; Thomas Kissel
Prospects for cationic polymers in gene and oligonucleotide therapy against cancer.
Advanced drug delivery reviews 2002;54(5):715-58.
2002: Keith D Jensen; Pavla Kopecková; Jindrich Kopecek
Antisense oligonucleotides delivered to the lysosome escape and actively inhibit the hepatitis B virus.
Bioconjugate chemistry 2002;13(5):975-84.
2002: Ayelet David; Pavla Kopecková; Jindrich Kopecek; Abraham Rubinstein
The role of galactose, lactose, and galactose valency in the biorecognition of N-(2-hydroxypropyl)methacrylamide copolymers by human colon adenocarcinoma cells.
Pharmaceutical research 2002;19(8):1114-22.
2002: Dong Wang; Michal Pechar; Weijie Li; Pavla Kopecková; Dieter Brömme; Jindrich Kopecek
Inhibition of cathepsin K with lysosomotropic macromolecular inhibitors.
Biochemistry 2002;41(28):8849-59.
2002: Jindrich Kopecek
Polymer chemistry: swell gels.
Nature 2002;417(6887):388-9, 391.
2002: Aijun Tang; Jindrich Kopecek
Presentation of epitopes on genetically engineered peptides and selection of lymphoma-targeting moieties based on epitope biorecognition.
Biomacromolecules 2002;3(3):421-31.
2002: Yi Luo; Nicole J Bernshaw; Zheng-Rong Lu; Jindrich Kopecek; Glenn D Prestwich
Targeted delivery of doxorubicin by HPMA copolymer-hyaluronan bioconjugates.
Pharmaceutical research 2002;19(4):396-402.
2002: Thomas Merdan; Klaus Kunath; Dagmar Fischer; Jindrich Kopecek; Thomas Kissel
Intracellular processing of poly(ethylene imine)/ribozyme complexes can be observed in living cells by using confocal laser scanning microscopy and inhibitor experiments.
Pharmaceutical research 2002;19(2):140-6.
2002: Yuji Kasuya; Zheng-Rong Lu; Pavla Kopecková; S Esmail Tabibi; Jindrich Kopecek
Influence of the structure of drug moieties on the in vitro efficacy of HPMA copolymer-geldanamycin derivative conjugates.
Pharmaceutical research 2002;19(2):115-23.
2002: Zheng-Rong Lu; Jane-Guo Shiah; Shinji Sakuma; Pavla Kopecková; Jindrich Kopecek
Design of novel bioconjugates for targeted drug delivery.
Journal of controlled release : official journal of the Controlled Release Society 2002;78(1-3):165-73.
2001: A David; Pavla Kopecková; Abraham Rubinstein; Jindrich Kopecek
Enhanced biorecognition and internalization of HPMA copolymers containing multiple or multivalent carbohydrate side-chains by human hepatocarcinoma cells.
Bioconjugate chemistry 2001;12(6):890-9.
2001: Yuji Kasuya; Z Lu; Pavla Kopecková; Jindrich Kopecek
Improved synthesis and evaluation of 17-substituted aminoalkylgeldanamycin derivatives applicable to drug delivery systems.
Bioorganic & medicinal chemistry letters 2001;11(16):2089-91.
2001: S Sakuma; Zheng-Rong Lu; Pavla Kopecková; Jindrich Kopecek
Biorecognizable HPMA copolymer-drug conjugates for colon-specific delivery of 9-aminocamptothecin.
Journal of controlled release : official journal of the Controlled Release Society 2001;75(3):365-79.
2001: S Wróblewski; M Berenson; Pavla Kopecková; Jindrich Kopecek
Potential of lectin-N-(2-hydroxypropyl)methacrylamide copolymer-drug conjugates for the treatment of pre-cancerous conditions.
Journal of controlled release : official journal of the Controlled Release Society 2001;74(1-3):283-93.
2001: Monica Tijerina; Pavla Kopecková; Jindrich Kopecek
The effects of subcellular localization of N-(2-hydroxypropyl)methacrylamide copolymer-Mce(6) conjugates in a human ovarian carcinoma.
Journal of controlled release : official journal of the Controlled Release Society 2001;74(1-3):269-73.
2001: Zheng-Rong Lu; Jane-Guo Shiah; Pavla Kopecková; Jindrich Kopecek
Preparation and biological evaluation of polymerizable antibody Fab' fragment targeted polymeric drug delivery system.
Journal of controlled release : official journal of the Controlled Release Society 2001;74(1-3):263-8.
2001: Jane-Guo Shiah; Yongen Sun; Pavla Kopecková; C Matthew Peterson; Richard C Straight; Jindrich Kopecek
Combination chemotherapy and photodynamic therapy of targetable N-(2-hydroxypropyl)methacrylamide copolymer-doxorubicin/mesochlorin e(6)-OV-TL 16 antibody immunoconjugates.
Journal of controlled release : official journal of the Controlled Release Society 2001;74(1-3):249-53.
2001: Yuji Kasuya; Zheng-Rong Lu; Pavla Kopecková; Tamara Minko; S Esmail Tabibi; Jindrich Kopecek
Synthesis and characterization of HPMA copolymer-aminopropylgeldanamycin conjugates.
Journal of controlled release : official journal of the Controlled Release Society 2001;74(1-3):203-11.
2001: Jindrich Kopecek; Pavla Kopecková; Tamara Minko; Zheng-Rong Lu; C Matthew Peterson
Water soluble polymers in tumor targeted delivery.
Journal of controlled release : official journal of the Controlled Release Society 2001;74(1-3):147-58.
2001: A Tang; Chun Wang; Russell J Stewart; Jindrich Kopecek
The coiled coils in the design of protein-based constructs: hybrid hydrogels and epitope displays.
Journal of controlled release : official journal of the Controlled Release Society 2001;72(1-3):57-70.
2001: Tamara Minko; Pavla Kopecková; Jindrich Kopecek
Preliminary evaluation of caspases-dependent apoptosis signaling pathways of free and HPMA copolymer-bound doxorubicin in human ovarian carcinoma cells.
Journal of controlled release : official journal of the Controlled Release Society 2001;71(3):227-37.
2001: S Wróblewski; Blanka Ríhová; Pavel Rossmann; T Hudcovicz; Zuzana Reháková; Pavla Kopecková; Jindrich Kopecek
The influence of a colonic microbiota on HPMA copolymer lectin conjugates binding in rodent intestine.
Journal of drug targeting 2001;9(2):85-94.
2001: Keith D Jensen; Pavla Kopecková; John H B Bridge; Jindrich Kopecek
The cytoplasmic escape and nuclear accumulation of endocytosed and microinjected HPMA copolymers and a basic kinetic study in Hep G2 cells.
AAPS pharmSci 2001;3(4):E32.
2001: Chun Wang; Jindrich Kopecek; Russell J Stewart
Hybrid hydrogels cross-linked by genetically engineered coiled-coil block proteins.
Biomacromolecules 2001;2(3):912-20.
2001: KD Fowers; Jon Callahan; P Byron; Jindrich Kopecek
Preparation of Fab' from murine IgG2a for thiol reactive conjugation.
Journal of drug targeting 2001;9(4):281-94.
2001: Zheng-Rong Lu; Song-Qi Gao; Pavla Kopecková; Jindrich Kopecek
Modification of cyclosporin A and conjugation of its derivative to HPMA copolymers.
Bioconjugate chemistry 2001;12(1):129-33.
2001: Jane-Guo Shiah; M Dvorák; Pavla Kopecková; Yongen Sun; C Matthew Peterson; Jindrich Kopecek
Biodistribution and antitumour efficacy of long-circulating N-(2-hydroxypropyl)methacrylamide copolymer-doxorubicin conjugates in nude mice.
European journal of cancer (Oxford, England : 1990) 2001;37(1):131-9.
2000: Monica Tijerina; KD Fowers; Pavla Kopecková; Jindrich Kopecek
Chronic exposure of human ovarian carcinoma cells to free or HPMA copolymer-bound mesochlorin e6 does not induce P-glycoprotein-mediated multidrug resistance.
Biomaterials 2000;21(21):2203-10.
2000: M Demoy; Tamara Minko; Pavla Kopecková; Jindrich Kopecek
Time- and concentration-dependent apoptosis and necrosis induced by free and HPMA copolymer-bound doxorubicin in human ovarian carcinoma cells.
Journal of controlled release : official journal of the Controlled Release Society 2000;69(1):185-96.
2000: S Wróblewski; M Berenson; Pavla Kopecková; Jindrich Kopecek
Biorecognition of HPMA copolymer-lectin conjugates as an indicator of differentiation of cell-surface glycoproteins in development, maturation, and diseases of human and rodent gastrointestinal tissues.
Journal of biomedical materials research 2000;51(3):329-42.
2000: L Chen; Jindrich Kopecek; Russell J Stewart
Responsive hybrid hydrogels with volume transitions modulated by a titin immunoglobulin module.
Bioconjugate chemistry 2000;11(5):734-40.
2000: Jindrich Kopecek; Pavla Kopecková; Tamara Minko; Z Lu
HPMA copolymer-anticancer drug conjugates: design, activity, and mechanism of action.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2000;50(1):61-81.
2000: Tamara Minko; P Kopeckova; Vitaly Pozharov; Keith D Jensen; Jindrich Kopecek
The influence of cytotoxicity of macromolecules and of VEGF gene modulated vascular permeability on the enhanced permeability and retention effect in resistant solid tumors.
Pharmaceutical research 2000;17(5):505-14.
2000: A Tang; Chun Wang; R Stewart; Jindrich Kopecek
Self-assembled peptides exposing epitopes recognizable by human lymphoma cells.
Bioconjugate chemistry 2000;11(3):363-71.
2000: Tamara Minko; Pavla Kopecková; Jindrich Kopecek
Efficacy of the chemotherapeutic action of HPMA copolymer-bound doxorubicin in a solid tumor model of ovarian carcinoma.
International journal of cancer. Journal international du cancer 2000;86(1):108-17.
2000: Jane-Guo Shiah; Yongen Sun; C Matthew Peterson; Richard C Straight; Jindrich Kopecek
Antitumor activity of N-(2-hydroxypropyl) methacrylamide copolymer-Mesochlorine e6 and adriamycin conjugates in combination treatments.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(3):1008-15.
2000: D Wang; J P Kopecková; Tamara Minko; V Nanayakkara; Jindrich Kopecek
Synthesis of starlike N-(2-hydroxypropyl)methacrylamide copolymers: potential drug carriers.
Biomacromolecules 2000;1(3):313-9.
2000: P R Hart; Pavla Kopecková; V Omelyanenko; Elena Y Enioutina; Jindrich Kopecek
HPMA copolymer-modified avidin: immune response.
Journal of biomaterials science. Polymer edition 2000;11(1):1-12.
2000: Zheng-Rong Lu; Song-Qi Gao; Pavla Kopecková; Jindrich Kopecek
Synthesis of bioadhesive lectin-HPMA copolymer-cyclosporin conjugates.
Bioconjugate chemistry 2000;11(1):3-7.
2000: Klaus Kunath; Pavla Kopecková; Tamara Minko; Jindrich Kopecek
HPMA copolymer-anticancer drug-OV-TL16 antibody conjugates. 3. The effect of free and polymer-bound adriamycin on the expression of some genes in the OVCAR-3 human ovarian carcinoma cell line.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2000;49(1):11-5.
1999: J J Shiah; Yongen Sun; C Matthew Peterson; Jindrich Kopecek
Biodistribution of free and N-(2-hydroxypropyl)methacrylamide copolymer-bound mesochlorin e(6) and adriamycin in nude mice bearing human ovarian carcinoma OVCAR-3 xenografts.
Journal of controlled release : official journal of the Controlled Release Society 1999;61(1-2):145-57.
1999: M Dvorák; Pavla Kopecková; Jindrich Kopecek
High-molecular weight HPMA copolymer-adriamycin conjugates.
Journal of controlled release : official journal of the Controlled Release Society 1999;60(2-3):321-32.
1999: J D Spikes; H R Shen; Pavla Kopecková; Jindrich Kopecek
Photodynamic crosslinking of proteins. III. Kinetics of the FMN- and rose bengal-sensitized photooxidation and intermolecular crosslinking of model tyrosine-containing N-(2-hydroxypropyl)methacrylamide copolymers.
Photochemistry and photobiology 1999;70(2):130-7.
1999: V Omelyanenko; Pavla Kopecková; R K Prakash; C D Ebert; Jindrich Kopecek
Biorecognition of HPMA copolymer-adriamycin conjugates by lymphocytes mediated by synthetic receptor binding epitopes.
Pharmaceutical research 1999;16(7):1010-9.
1999: Tamara Minko; Pavla Kopecková; Jindrich Kopecek
Comparison of the anticancer effect of free and HPMA copolymer-bound adriamycin in human ovarian carcinoma cells.
Pharmaceutical research 1999;16(7):986-96.
1999: J M Lu; C Matthew Peterson; J Guo-Shiah; Z W Gu; C A Peterson; Richard C Straight; Jindrich Kopecek
Cooperativity between free and N-(2-hydroxypropyl) methacrylamide copolymer bound adriamycin and meso-chlorin e6 monoethylene diamine induced photodynamic therapy in human epithelial ovarian carcinoma in vitro.
International journal of oncology 1999;15(1):5-16.
1999: Tamara Minko; Pavla Kopecková; Jindrich Kopecek
Chronic exposure to HPMA copolymer-bound adriamycin does not induce multidrug resistance in a human ovarian carcinoma cell line.
Journal of controlled release : official journal of the Controlled Release Society 1999;59(2):133-48.
1999: R H Lu; Pavla Kopecková; Jindrich Kopecek
Degradation and aggregation of human calcitonin in vitro.
Pharmaceutical research 1999;16(3):359-67.
1999: Chun Wang; Russell J Stewart; Jindrich Kopecek
Hybrid hydrogels assembled from synthetic polymers and coiled-coil protein domains.
Nature 1999;397(6718):417-20.
1998: Zheng-Rong Lu; Pavla Kopecková; Z Wu; Jindrich Kopecek
Functionalized semitelechelic poly[N-(2-hydroxypropyl)methacrylamide] for protein modification.
Bioconjugate chemistry 1998;9(6):793-804.
1998: Tamara Minko; Pavla Kopecková; Vitaly Pozharov; Jindrich Kopecek
HPMA copolymer bound adriamycin overcomes MDR1 gene encoded resistance in a human ovarian carcinoma cell line.
Journal of controlled release : official journal of the Controlled Release Society 1998;54(2):223-33.
1998: E O Akala; Pavla Kopecková; Jindrich Kopecek
Novel pH-sensitive hydrogels with adjustable swelling kinetics.
Biomaterials 1998;19(11-12):1037-47.
1998: V Omelyanenko; Pavla Kopecková; C Gentry; Jindrich Kopecek
Targetable HPMA copolymer-adriamycin conjugates. Recognition, internalization, and subcellular fate.
Journal of controlled release : official journal of the Controlled Release Society 1998;53(1-3):25-37.
1998: V Omelyanenko; C Gentry; Pavla Kopecková; Jindrich Kopecek
HPMA copolymer-anticancer drug-OV-TL16 antibody conjugates. II. Processing in epithelial ovarian carcinoma cells in vitro.
International journal of cancer. Journal international du cancer 1998;75(4):600-8.
1998: Jane-Guo Shiah; Cestmír Konák; J D Spikes; Jindrich Kopecek
Influence of pH on aggregation and photoproperties of n-(2-hydroxypropyl)methacrylamide copolymer-meso-chlorin e6 conjugates.
Drug delivery 1998;5(2):119-26.
1997: Hamidreza Ghandehari; Pavla Kopecková; Jindrich Kopecek
In vitro degradation of pH-sensitive hydrogels containing aromatic azo bonds.
Biomaterials 1997;18(12):861-72.
1997: H C Chiu; Pavla Kopecková; S S Deshmane; Jindrich Kopecek
Lysosomal degradability of poly(alpha-amino acids).
Journal of biomedical materials research 1997;34(3):381-92.
1996: D A Putnam; J G Shiah; Jindrich Kopecek
Intracellularly biorecognizable derivatives of 5-fluorouracil. Implications for site-specific delivery in the human condition.
Biochemical pharmacology 1996;52(6):957-62.
1996: H R Shen; J D Spikes; Pavla Kopecková; Jindrich Kopecek
Photodynamic crosslinking of proteins. II. Photocrosslinking of a model protein-ribonuclease A.
Journal of photochemistry and photobiology. B, Biology 1996;35(3):213-9.
1996: C Matthew Peterson; J M Lu; Y Sun; C A Peterson; J G Shiah; R C Straight; Jindrich Kopecek
Combination chemotherapy and photodynamic therapy with N-(2-hydroxypropyl) methacrylamide copolymer-bound anticancer drugs inhibit human ovarian carcinoma heterotransplanted in nude mice.
Cancer research 1996;56(17):3980-5.
1996: H R Shen; J D Spikes; P Kopeceková; Jindrich Kopecek
Photodynamic crosslinking of proteins. I. Model studies using histidine- and lysine-containing N-(2-hydroxypropyl)methacrylamide copolymers.
Journal of photochemistry and photobiology. B, Biology 1996;34(2-3):203-10.
1996: V Omelyanenko; Pavla Kopecková; C Gentry; J G Shiah; Jindrich Kopecek
HPMA copolymer-anticancer drug-OV-TL16 antibody conjugates. 1. influence of the method of synthesis on the binding affinity to OVCAR-3 ovarian carcinoma cells in vitro.
Journal of drug targeting 1996;3(5):357-73.
1995: C Matthew Peterson; J M Lu; Z W Gu; J G Shiah; K Lythgoe; C A Peterson; R C Straight; Jindrich Kopecek
Isobolographic assessment of the interaction between adriamycin and photodynamic therapy with meso-chlorin e6 monoethylene diamine in human epithelial ovarian carcinoma (OVCAR-3) in vitro.
Journal of the Society for Gynecologic Investigation 1995;2(6):772-7.
1995: D Putnam; Jindrich Kopecek
Enantioselective release of 5-fluorouracil from N-(2-hydroxypropyl)methacrylamide-based copolymers via lysosomal enzymes.
Bioconjugate chemistry 1995;6(4):483-92.
1995: S Kamei; Jindrich Kopecek
Prolonged blood circulation in rats of nanospheres surface-modified with semitelechelic poly[N-(2-hydroxypropyl)methacrylamide].
Pharmaceutical research 1995;12(5):663-8.
1995: Blanka Ríhová; R C Rathi; Pavla Kopecková; Jindrich Kopecek
Bioadhesive polymers for oral drug delivery.
Advances in experimental medicine and biology 1995;371B():1491-4.
1994: H R Yen; S Oscarsson; Karel Ulbrich; Jindrich Kopecek
Adsorption and activation of zymogens at solid-liquid interfaces. I. Chymotrypsinogen on alkylamino modified silica derivatives.
Journal of biomedical materials research 1994;28(2):247-57.
1994: N L Krinick; Y Sun; D Joyner; J D Spikes; R C Straight; Jindrich Kopecek
A polymeric drug delivery system for the simultaneous delivery of drugs activatable by enzymes and/or light.
Journal of biomaterials science. Polymer edition 1994;5(4):303-24.
1993: H C Chiu; S Zalipsky; Pavla Kopecková; Jindrich Kopecek
Enzymatic activity of chymotrypsin and its poly(ethylene glycol) conjugates toward low and high molecular weight substrates.
Bioconjugate chemistry 1993;4(4):290-5.
1992: H Brøndsted; Jindrich Kopecek
Hydrogels for site-specific drug delivery to the colon: in vitro and in vivo degradation.
Pharmaceutical research 1992;9(12):1540-5.
1991: H Brøndsted; Jindrich Kopecek
Hydrogels for site-specific oral drug delivery: synthesis and characterization.
Biomaterials 1991;12(6):584-92.
1991: Jindrich Kopecek
Targetable polymeric anticancer drugs. Temporal control of drug activity.
Annals of the New York Academy of Sciences 1991;618():335-44.
1990: J H Lee; P Kopeckova; Jindrich Kopecek; Joseph D Andrade
Surface properties of copolymers of alkyl methacrylates with methoxy (polyethylene oxide) methacrylates and their application as protein-resistant coatings.
Biomaterials 1990;11(7):455-64.
1990: Leonard W Seymour; Karel Ulbrich; Jirí Strohalm; Jindrich Kopecek; Ruth Duncan
The pharmacokinetics of polymer-bound adriamycin.
Biochemical pharmacology 1990;39(6):1125-31.
1990: V Subr; Ruth Duncan; Jindrich Kopecek
Release of macromolecules and daunomycin from hydrophilic gels containing enzymatically degradable bonds.
Journal of biomaterials science. Polymer edition 1990;1(4):261-78.
1989: P A Flanagan; Pavla Kopecková; Jindrich Kopecek; Ruth Duncan
Evaluation of protein-N-(2-hydroxypropyl)methacrylamide copolymer conjugates as targetable drug carriers. 1. Binding, pinocytic uptake and intracellular distribution of transferrin and anti-transferrin receptor antibody conjugates.
Biochimica et biophysica acta 1989;993(1):83-91.
1989: K B O'Hare; I C Hume; L Scarlett; V Chytrý; Pavla Kopecková; Jindrich Kopecek; Ruth Duncan
Effect of galactose on interaction of N-(2-hydroxypropyl)methacrylamide copolymers with hepatoma cells in culture: preliminary application to an anticancer agent, daunomycin.
Hepatology (Baltimore, Md.) 1989;10(2):207-14.
1989: B Rihova; Martin Bilej; V Vetvicka; Karel Ulbrich; Jirí Strohalm; Jindrich Kopecek; Ruth Duncan
Biocompatibility of N-(2-hydroxypropyl) methacrylamide copolymers containing adriamycin. Immunogenicity, and effect on haematopoietic stem cells in bone marrow in vivo and mouse splenocytes and human peripheral blood lymphocytes in vitro.
Biomaterials 1989;10(5):335-42.
1989: J Cassidy; Ruth Duncan; G J Morrison; Jirí Strohalm; D Plocova; Jindrich Kopecek; S B Kaye
Activity of N-(2-hydroxypropyl)methacrylamide copolymers containing daunomycin against a rat tumour model.
Biochemical pharmacology 1989;38(6):875-9.
1989: J H Lee; Jindrich Kopecek; Joseph D Andrade
Protein-resistant surfaces prepared by PEO-containing block copolymer surfactants.
Journal of biomedical materials research 1989;23(3):351-68.
1988: Ruth Duncan; Pavla Kopecková; Jirí Strohalm; I C Hume; J B Lloyd; Jindrich Kopecek
Anticancer agents coupled to N-(2-hydroxypropyl)methacrylamide copolymers. II. Evaluation of daunomycin conjugates in vivo against L1210 leukaemia.
British journal of cancer 1988;57(2):147-56.
1988: Joseph D Andrade; J Herron; J N Lin; H Yen; Jindrich Kopecek; P Kopeckova
On-line sensors for coagulation proteins: concept and progress report.
Biomaterials 1988;9(1):76-9.
1988: Blanka Ríhová; Pavla Kopecková; Jirí Strohalm; Pavel Rossmann; V Vĕtvicka; Jindrich Kopecek
Antibody-directed affinity therapy applied to the immune system: in vivo effectiveness and limited toxicity of daunomycin conjugated to HPMA copolymers and targeting antibody.
Clinical immunology and immunopathology 1988;46(1):100-14.
1987: Leonard W Seymour; Ruth Duncan; Pavla Kopecková; Jindrich Kopecek
Daunomycin- and adriamycin-N-(2-hydroxypropyl)methacrylamide copolymer conjugates; toxicity reduction by improved drug-delivery.
Cancer treatment reviews 1987;14(3-4):319-27.
1987: Leonard W Seymour; Ruth Duncan; Jirí Strohalm; Jindrich Kopecek
Effect of molecular weight (Mw) of N-(2-hydroxypropyl)methacrylamide copolymers on body distribution and rate of excretion after subcutaneous, intraperitoneal, and intravenous administration to rats.
Journal of biomedical materials research 1987;21(11):1341-58.
1987: Ruth Duncan; P Kopecková-Rejmanová; Jirí Strohalm; I Hume; H C Cable; J Pohl; J B Lloyd; Jindrich Kopecek
Anticancer agents coupled to N-(2-hydroxypropyl)methacrylamide copolymers. I. Evaluation of daunomycin and puromycin conjugates in vitro.
British journal of cancer 1987;55(2):165-74.
1986: Ruth Duncan; H C Cable; Jirí Strohalm; Jindrich Kopecek
Pinocytic capture and exocytosis of rat immunoglobulin IgG-N-(2-hydroxypropyl)methacrylamide copolymer conjugates by rat visceral yolk sacs cultured in vitro.
Bioscience reports 1986;6(10):869-77.
1986: V Vĕtvicka; L Fornůsek; P W Kincade; Jindrich Kopecek
Co-expression of different types of Fc receptors on murine peritoneal macrophages.
European journal of immunology 1986;16(8):901-5.
1986: Helena Tlaskalová-Hogenová; V Vĕtvicka; M Pospísil; L Fornůsek; L Prokesova; J Coupek; A Frydrychová; Jindrich Kopecek; H Fiebig; J Brochier
Separation of human lymphoid cells by affinity chromatography and cell surface labelling by hydroxyethyl methacrylate particles using monoclonal antibodies.
Journal of chromatography 1986;376():401-8.
1986: Blanka Ríhová; Jindrich Kopecek; P Kopecková-Rejmanová; Jirí Strohalm; Dana Plocová; H Semorádová
Bioaffinity therapy with antibodies and drugs bound to soluble synthetic polymers.
Journal of chromatography 1986;376():221-33.
1986: Ruth Duncan; L C Seymour; L Scarlett; J B Lloyd; P Rejmanová; Jindrich Kopecek
Fate of N-(2-hydroxypropyl)methacrylamide copolymers with pendent galactosamine residues after intravenous administration to rats.
Biochimica et biophysica acta 1986;880(1):62-71.
1985: V Vĕtvicka; L Fornůsek; Blanka Ríhová; Jindrich Kopecek
Properties of macrophages from low- and high-responder strains of mice. I. Effect of antigenic stimulation.
Folia biologica 1985;31(1):20-33.
1985: P Rejmanová; Jindrich Kopecek; Ruth Duncan; J B Lloyd
Stability in rat plasma and serum of lysosomally degradable oligopeptide sequences in N-(2-hydroxypropyl) methacrylamide copolymers.
Biomaterials 1985;6(1):45-8.
1985: Jindrich Kopecek; P Rejmanová; Ruth Duncan; J B Lloyd
Controlled release of drug model from N-(2-hydroxypropyl)-methacrylamide copolymers.
Annals of the New York Academy of Sciences 1985;446():93-104.
1984: V Vĕtvicka; L Fornůsek; M Holub; J Zídková; Jindrich Kopecek
Macrophages of athymic nude mice: Fc receptors, C receptors, phagocytic and pinocytic activities.
European journal of cell biology 1984;35(1):35-40.
1984: Ruth Duncan; H C Cable; P Rejmanová; Jindrich Kopecek; J B Lloyd
Tyrosinamide residues enhance pinocytic capture of N-(2-hydroxypropyl)methacrylamide copolymers.
Biochimica et biophysica acta 1984;799(1):1-8.
1984: B Rihová; Jindrich Kopecek; Karel Ulbrich; M Pospisil; P Mancal
Effect of the chemical structure of N-(2-hydroxypropyl)methacrylamide copolymers on their ability to induce antibody formation in inbred strains of mice.
Biomaterials 1984;5(3):143-8.
1983: Ruth Duncan; Jindrich Kopecek; P Rejmanová; J B Lloyd
Targeting of N-(2-hydroxypropyl)methacrylamide copolymers to liver by incorporation of galactose residues.
Biochimica et biophysica acta 1983;755(3):518-21.
1983: Blanka Ríhová; Karel Ulbrich; Jindrich Kopecek; P Mancal
Immunogenicity of N-(2-hydroxypropyl)-methacrylamide copolymers--potential hapten or drug carriers.
Folia microbiologica 1983;28(3):217-27.
1983: V Vĕtvicka; L Fornůsek; Jindrich Kopecek; D Prikrylová
Phagocytosis of 2-hydroxyethylmethacrylate copolymer particles by different types of macrophages.
Folia biologica 1983;29(6):424-8.
1983: L Fornůsek; Jindrich Kopecek; V Vĕtvicka
An advantageous method for detection of Fc-receptors and for studying Fc-receptor-mediated phagocytosis.
Immunology letters 1983;7(1):29-33.
1983: M V Solovskij; Karel Ulbrich; Jindrich Kopecek
Synthesis of N-(2-hydroxypropyl)methacrylamide copolymers with antimicrobial activity.
Biomaterials 1983;4(1):44-8.
1982: Ruth Duncan; H C Cable; J B Lloyd; P Rejmanová; Jindrich Kopecek
Degradation of side-chains of N-(2-hydroxypropyl)methacrylamide copolymers by lysosomal thiol-proteinases.
Bioscience reports 1982;2(12):1041-6.
1982: V Vĕtvicka; L Fornůsek; Jindrich Kopecek; J Kamínková; L Kaspárek; M Vránová
Phagocytosis of human blood leukocytes: a simple micromethod.
Immunology letters 1982;5(2):97-100.
1982: Karel Ulbrich; Jirí Strohalm; Jindrich Kopecek
Polymers containing enzymatically degradable bonds. VI. Hydrophilic gels cleavable by chymotrypsin.
Biomaterials 1982;3(3):150-4.
1980: Karel Ulbrich; E I Zacharieva; B Obereigner; Jindrich Kopecek
Polymers containing enzymatically degradable bonds V. Hydrophilic polymers degradable by papain.
Biomaterials 1980;1(4):199-204.