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Jindrich Kopecek

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
88
Kopecková, Pavla
17
Duncan, Ruth
14
Minko, Tamara
13
Wang, Dong
12
Lu, Zheng-Rong
11
Peterson, Matthew
10
Strohalm, Jirí
9
Vetvicka, Vaclav
8
Ulbrich, Karel
8
Yang, Jiyuan
8
Miller, Scott
7
Tijerina, Monica
7
Sun, Yongen
6
Ríhová, Blanka
6
Shiah, Jane-Guo

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Publications

TOP 3
Gao Song-Qi; Sun Yongen; Kopecková Pavla; Peterson C Matthew; Kopecek Jindrich
Antitumor efficacy of colon-specific HPMA copolymer/9-aminocamptothecin conjugates in mice bearing human-colon carcinoma xenografts.
Radu-Wu Larisa C; Yang Jiyuan; Wu Kuangshi; Kopecek Jindrich
Self-assembled hydrogels from poly[N-(2-hydroxypropyl)methacrylamide] grafted with beta-sheet peptides.
Liu Jihua; Kopecková Pavla; Bühler Patrick; Wolf Philipp; Pan Huaizhong; Bauer Hillevi; Elsässer-Beile Ursula; Kopecek Jindrich
Biorecognition and subcellular trafficking of HPMA copolymer-anti-PSMA antibody conjugates by prostate cancer cells.

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All Publications

2009: Gao Song-Qi; Sun Yongen; Kopecková Pavla; Peterson C Matthew; Kopecek Jindrich
Antitumor efficacy of colon-specific HPMA copolymer/9-aminocamptothecin conjugates in mice bearing human-colon carcinoma xenografts.
Macromolecular bioscience 2009;9(11):1135-42.
2009: Radu-Wu Larisa C; Yang Jiyuan; Wu Kuangshi; Kopecek Jindrich
Self-assembled hydrogels from poly[N-(2-hydroxypropyl)methacrylamide] grafted with beta-sheet peptides.
Biomacromolecules 2009;10(8):2319-27.
2009: Liu Jihua; Kopecková Pavla; Bühler Patrick; Wolf Philipp; Pan Huaizhong; Bauer Hillevi; Elsässer-Beile Ursula; Kopecek Jindrich
Biorecognition and subcellular trafficking of HPMA copolymer-anti-PSMA antibody conjugates by prostate cancer cells.
Molecular pharmaceutics 2009;6(3):959-70.
2009: Kopecek Jindrich; Yang Jiyuan
Peptide-directed self-assembly of hydrogels.
Acta biomaterialia 2009;5(3):805-16.
2009: Johnson Russell N; Kopecková Pavla; Kopecek Jindrich
Synthesis and evaluation of multivalent branched HPMA copolymer-Fab' conjugates targeted to the B-cell antigen CD20.
Bioconjugate chemistry 2009;20(1):129-37.
2009: Radu Larisa Cristina; Yang Jiyuan; Kopecek Jindrich
Self-assembling diblock copolymers of poly[N-(2-hydroxypropyl)methacrylamide] and a beta-sheet peptide.
Macromolecular bioscience 2009;9(1):36-44.
2009: Segal Ehud; Pan Huaizhong; Ofek Paula; Udagawa Taturo; Kopecková Pavla; Kopecek Jindrich; Satchi-Fainaro Ronit
Targeting angiogenesis-dependent calcified neoplasms using combined polymer therapeutics.
PloS one 2009;4(4):e5233.
2008: Miller S C; Pan H; Wang D; Bowman B M; Kopecková P; Kopecek J
Feasibility of using a bone-targeted, macromolecular delivery system coupled with prostaglandin E(1) to promote bone formation in aged, estrogen-deficient rats.
Pharmaceutical research 2008;25(12):2889-95.
2008: Yuan Weiwei; Yang Jiyuan; Kopecková Pavla; Kopecek Jindrich
Smart hydrogels containing adenylate kinase: translating substrate recognition into macroscopic motion.
Journal of the American Chemical Society 2008;130(47):15760-1.
2008: Cuchelkar Vaikunth; Kopecková Pavla; Kopecek Jindrich
Novel HPMA copolymer-bound constructs for combined tumor and mitochondrial targeting.
Molecular pharmaceutics 2008;5(5):776-86.
2008: Hongrapipat Jarunee; Kopecková Pavla; Liu Jihua; Prakongpan Sompol; Kopecek Jindrich
Combination chemotherapy and photodynamic therapy with fab' fragment targeted HPMA copolymer conjugates in human ovarian carcinoma cells.
Molecular pharmaceutics 2008;5(5):696-709.
2008: Pan Huaizhong; Sima Monika; Kopecková Pavla; Wu Kuangshi; Gao Songqi; Liu Jihua; Wang Dong; Miller Scott C; Kopecek Jindrich
Biodistribution and pharmacokinetic studies of bone-targeting N-(2-hydroxypropyl)methacrylamide copolymer-alendronate conjugates.
Molecular pharmaceutics 2008;5(4):548-58.
2008: Pan Huaizhong; Liu Jihua; Dong Yuanyi; Sima Monika; Kopecková Pavla; Brandi Maria Luisa; Kopecek Jindrich
Release of prostaglandin E(1) from N-(2-hydroxypropyl)methacrylamide copolymer conjugates by bone cells.
Macromolecular bioscience 2008;8(7):599-605.
2008: Cuchelkar Vaikunth; Kopecková Pavla; Kopecek Jindrich
Synthesis and biological evaluation of disulfide-linked HPMA copolymer-mesochlorin e6 conjugates.
Macromolecular bioscience 2008;8(5):375-83.
2008: Hongrapipat J; Kopecková P; Prakongpan S; Kopecek J
Enhanced antitumor activity of combinations of free and HPMA copolymer-bound drugs.
International journal of pharmaceutics 2008;351(1-2):259-70.
2008: Xu Chunyu; Kopecek Jindrich
Genetically engineered block copolymers: influence of the length and structure of the coiled-coil blocks on hydrogel self-assembly.
Pharmaceutical research 2008;25(3):674-82.
2008: Yang Jiyuan; Wu Kuangshi; Konák Cestmír; Kopecek Jindrich
Dynamic light scattering study of self-assembly of HPMA hybrid graft copolymers.
Biomacromolecules 2008;9(2):510-7.
2008: Gao Song-Qi; Sun Yongen; Kopecková Pavla; Peterson C Matthew; Kopecek Jindrich
Pharmacokinetic modeling of absorption behavior of 9-aminocamptothecin (9-AC) released from colon-specific HPMA copolymer-9-AC conjugate in rats.
Pharmaceutical research 2008;25(1):218-26.
2007: Pan Huaizhong; Kopecková Pavla; Liu Jihua; Wang Dong; Miller Scott C; Kopecek Jindrich
Stability in plasmas of various species of HPMA copolymer-PGE1 conjugates.
Pharmaceutical research 2007;24(12):2270-80.
2007: Malugin A; Kopecková P; Kopecek J
Liberation of doxorubicin from HPMA copolymer conjugate is essential for the induction of cell cycle arrest and nuclear fragmentation in ovarian carcinoma cells.
Journal of controlled release : official journal of the Controlled Release Society 2007;124(1-2):6-10.
2007: Kopecek Jindrich
Hydrogel biomaterials: a smart future?
Biomaterials 2007;28(34):5185-92.
2007: Wang Dong; Miller Scott C; Shlyakhtenko Luda S; Portillo Alexander M; Liu Xin-Ming; Papangkorn Kongnara; Kopecková Pavla; Lyubchenko Yuri; Higuchi William I; Kopecek Jindrich
Osteotropic Peptide that differentiates functional domains of the skeleton.
Bioconjugate chemistry 2007;18(5):1375-8.
2007: Ding Hui; Kopecková Pavla; Kopecek Jindrich
Self-association properties of HPMA copolymers containing an amphipathic heptapeptide.
Journal of drug targeting 2007;15(7-8):465-74.
2007: Gao Song-Qi; Lu Zheng-Rong; Kopecková Pavla; Kopecek Jindrich
Biodistribution and pharmacokinetics of colon-specific HPMA copolymer--9-aminocamptothecin conjugate in mice.
Journal of controlled release : official journal of the Controlled Release Society 2007;117(2):179-85.
2006: Wang Dong; Sima Monika; Mosley R Lee; Davda Jasmine P; Tietze Nicole; Miller Scott C; Gwilt Peter R; Kopecková Pavla; Kopecek Jindrich
Pharmacokinetic and biodistribution studies of a bone-targeting drug delivery system based on N-(2-hydroxypropyl)methacrylamide copolymers.
Molecular pharmaceutics 2006;3(6):717-25.
2006: Ding Hui; Prodinger Wolfgang M; Kopecek Jindrich
Two-step fluorescence screening of CD21-binding peptides with one-bead one-compound library and investigation of binding properties of N-(2-hydroxypropyl)methacrylamide copolymer-peptide conjugates.
Biomacromolecules 2006;7(11):3037-46.
2006: Callahan Jon; Kopecek Jindrich
Semitelechelic HPMA copolymers functionalized with triphenylphosphonium as drug carriers for membrane transduction and mitochondrial localization.
Biomacromolecules 2006;7(8):2347-56.
2006: Pan Huaizhong; Kopecková Pavla; Wang Dong; Yang Jiyuan; Miller Scott; Kopecek Jindrich
Water-soluble HPMA copolymer--prostaglandin E1 conjugates containing a cathepsin K sensitive spacer.
Journal of drug targeting 2006;14(6):425-35.
2006: Malugin Alexander; Kopecková Pavla; Kopecek Jindrich
HPMA copolymer-bound doxorubicin induces apoptosis in ovarian carcinoma cells by the disruption of mitochondrial function.
Molecular pharmaceutics 2006;3(3):351-61.
2006: Yang Jiyuan; Xu Chunyu; Wang Chun; Kopecek Jindrich
Refolding hydrogels self-assembled from N-(2-hydroxypropyl)methacrylamide graft copolymers by antiparallel coiled-coil formation.
Biomacromolecules 2006;7(4):1187-95.
2006: Ding Hui; Prodinger Wolfgang M; Kopecek Jindrich
Identification of CD21-binding peptides with phage display and investigation of binding properties of HPMA copolymer-peptide conjugates.
Bioconjugate chemistry 2006;17(2):514-23.
2006: Yang Jiyuan; Xu Chunyu; Kopecková Pavla; Kopecek Jindrich
Hybrid hydrogels self-assembled from HPMA copolymers containing peptide grafts.
Macromolecular bioscience 2006;6(3):201-9.
2006: Chivukula Padmanabh; Dusek Karel; Wang Dong; Dusková-Smrcková Mirka; Kopecková Pavla; Kopecek Jindrich
Synthesis and characterization of novel aromatic azo bond-containing pH-sensitive and hydrolytically cleavable IPN hydrogels.
Biomaterials 2006;27(7):1140-51.
2006: Gao Song-Qi; Lu Zheng-Rong; Petri Boris; Kopecková Pavla; Kopecek Jindrich
Colon-specific 9-aminocamptothecin-HPMA copolymer conjugates containing a 1,6-elimination spacer.
Journal of controlled release : official journal of the Controlled Release Society 2006;110(2):323-31.
2005: Merdan Thomas; Kunath Klaus; Petersen Holger; Bakowsky Udo; Voigt Karl Heinz; Kopecek Jindrich; Kissel Thomas
PEGylation of poly(ethylene imine) affects stability of complexes with plasmid DNA under in vivo conditions in a dose-dependent manner after intravenous injection into mice.
Bioconjugate chemistry 2005;16(4):785-92.
2005: Xu Chunyu; Breedveld Victor; Kopecek Jindrich
Reversible hydrogels from self-assembling genetically engineered protein block copolymers.
Biomacromolecules 2005;6(3):1739-49.
2005: Wang Dong; Miller Scott C; Kopecková Pavla; Kopecek Jindrich
Bone-targeting macromolecular therapeutics.
Advanced drug delivery reviews 2005;57(7):1049-76.
2005: Wang Dong; Miller Scott C; Kopecek Jindrich
Targeted drug delivery for musculoskeletal diseases.
Advanced drug delivery reviews 2005;57(7):935-7.
2005: Nori Aparna; Kopecek Jindrich
Intracellular targeting of polymer-bound drugs for cancer chemotherapy.
Advanced drug delivery reviews 2005;57(4):609-36.
2005: Hyde Robyn M; Jensen Keith; Kopecek Jindrich; Broom Arthur D
Confocal microscopy studies of a model oligoribonucleotide HIV inhibitor.
Nucleosides, nucleotides & nucleic acids 2005;24(10-12):1875-84.
2005: Miller Scott C; Wang Dong; Kopecková Pavla; Kopecek Jindrich
Biopolymer-based delivery systems for advanced imaging and skeletal tissue-specific therapeutics.
Journal of bone and mineral metabolism 2005;23 Suppl():103-8.
2004: Senter Peter D; Kopecek Jindrich
Drug carriers in medicine and biology.
Molecular pharmaceutics 2004;1(6):395-8.
2004: Wang Dong; Miller Scott C; Sima Monika; Parker Dennis; Buswell Henry; Goodrich K Craig; Kopecková Pavla; Kopecek Jindrich
The arthrotropism of macromolecules in adjuvant-induced arthritis rat model: a preliminary study.
Pharmaceutical research 2004;21(10):1741-9.
2004: Wang D; Li W; Pechar M; Kopecková P; Brömme D; Kopecek J
Cathepsin K inhibitor-polymer conjugates: potential drugs for the treatment of osteoporosis and rheumatoid arthritis.
International journal of pharmaceutics 2004;277(1-2):73-9.
2004: Malugin Alexander; Kopecková Pavla; Kopecek Jindrich
HPMA copolymer-bound doxorubicin induces apoptosis in human ovarian carcinoma cells by a Fas-independent pathway.
Molecular pharmaceutics 2004;1(3):174-82.
2004: David A; Kopecková P; Minko Tamara; Rubinstein Abraham; Kopecek J
Design of a multivalent galactoside ligand for selective targeting of HPMA copolymer-doxorubicin conjugates to human colon cancer cells.
European journal of cancer (Oxford, England : 1990) 2004;40(1):148-57.
2003: Nishiyama Nobuhiro; Nori Aparna; Malugin Alexander; Kasuya Yuji; Kopecková Pavla; Kopecek Jindrich
Free and N-(2-hydroxypropyl)methacrylamide copolymer-bound geldanamycin derivative induce different stress responses in A2780 human ovarian carcinoma cells.
Cancer research 2003;63(22):7876-82.
2003: Dusek Karel; Dusková-Smrcková Miroslava; Ilavský Michal; Stewart Russell; Kopecek Jindrich
Swelling pressure induced phase-volume transition in hybrid biopolymer gels caused by unfolding of folded crosslinks: a model.
Biomacromolecules 2003;4(6):1818-26.
2003: Kopecek Jindrich
Smart and genetically engineered biomaterials and drug delivery systems.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2003;20(1):1-16.
2003: Merdan Thomas; Callahan Jon; Petersen Holger; Kunath Klaus; Bakowsky Udo; Kopecková Pavla; Kissel Thomas; Kopecek Jindrich
Pegylated polyethylenimine-Fab' antibody fragment conjugates for targeted gene delivery to human ovarian carcinoma cells.
Bioconjugate chemistry 2003;14(5):989-96.
2003: Wang Dong; Miller Scott; Sima Monika; Kopecková Pavla; Kopecek Jindrich
Synthesis and evaluation of water-soluble polymeric bone-targeted drug delivery systems.
Bioconjugate chemistry 2003;14(5):853-9.
2003: Nori Aparna; Jensen Keith D; Tijerina Monica; Kopecková Pavla; Kopecek Jindrich
Subcellular trafficking of HPMA copolymer-Tat conjugates in human ovarian carcinoma cells.
Journal of controlled release : official journal of the Controlled Release Society 2003;91(1-2):53-9.
2003: Tijerina Monica; Kopecková Pavla; Kopecek Jindrich
Mechanisms of cytotoxicity in human ovarian carcinoma cells exposed to free Mce6 or HPMA copolymer-Mce6 conjugates.
Photochemistry and photobiology 2003;77(6):645-52.
2003: Tijerina Monica; Kopecková Pavla; Kopecek Jindrich
Correlation of subcellular compartmentalization of HPMA copolymer-Mce6 conjugates with chemotherapeutic activity in human ovarian carcinoma cells.
Pharmaceutical research 2003;20(5):728-37.
2003: Jensen Keith D; Nori Aparna; Tijerina Monica; Kopecková Pavla; Kopecek Jindrich
Cytoplasmic delivery and nuclear targeting of synthetic macromolecules.
Journal of controlled release : official journal of the Controlled Release Society 2003;87(1-3):89-105.
2003: Nori Aparna; Jensen Keith D; Tijerina Monica; Kopecková Pavla; Kopecek Jindrich
Tat-conjugated synthetic macromolecules facilitate cytoplasmic drug delivery to human ovarian carcinoma cells.
Bioconjugate chemistry 2003;14(1):44-50.
2003: Peterson C Matthew; Shiah Jane-Guo; Sun Yongen; Kopecková Pavla; Minko Tamara; Straight Richard C; Kopecek Jindrich
HPMA copolymer delivery of chemotherapy and photodynamic therapy in ovarian cancer.
Advances in experimental medicine and biology 2003;519():101-23.
2002: Jensen Keith D; Kopecková Pavla; Kopecek Jindrich
Antisense oligonucleotides delivered to the lysosome escape and actively inhibit the hepatitis B virus.
Bioconjugate chemistry 2002;13(5):975-84.
2002: Merdan Thomas; Kopecek Jindrich; Kissel Thomas
Prospects for cationic polymers in gene and oligonucleotide therapy against cancer.
Advanced drug delivery reviews 2002;54(5):715-58.
2002: David Ayelet; Kopecková Pavla; Kopecek Jindrich; Rubinstein Abraham
The role of galactose, lactose, and galactose valency in the biorecognition of N-(2-hydroxypropyl)methacrylamide copolymers by human colon adenocarcinoma cells.
Pharmaceutical research 2002;19(8):1114-22.
2002: Wang Dong; Pechar Michal; Li Weijie; Kopecková Pavla; Brömme Dieter; Kopecek Jindrich
Inhibition of cathepsin K with lysosomotropic macromolecular inhibitors.
Biochemistry 2002;41(28):8849-59.
2002: Kopecek Jindrich
Polymer chemistry: swell gels.
Nature 2002;417(6887):388-9, 391.
2002: Tang Aijun; Kopecek Jindrich
Presentation of epitopes on genetically engineered peptides and selection of lymphoma-targeting moieties based on epitope biorecognition.
Biomacromolecules 2002;3(3):421-31.
2002: Luo Yi; Bernshaw Nicole J; Lu Zheng-Rong; Kopecek Jindrich; Prestwich Glenn D
Targeted delivery of doxorubicin by HPMA copolymer-hyaluronan bioconjugates.
Pharmaceutical research 2002;19(4):396-402.
2002: Merdan Thomas; Kunath Klaus; Fischer Dagmar; Kopecek Jindrich; Kissel Thomas
Intracellular processing of poly(ethylene imine)/ribozyme complexes can be observed in living cells by using confocal laser scanning microscopy and inhibitor experiments.
Pharmaceutical research 2002;19(2):140-6.
2002: Kasuya Yuji; Lu Zheng-Rong; Kopecková Pavla; Tabibi S Esmail; Kopecek Jindrich
Influence of the structure of drug moieties on the in vitro efficacy of HPMA copolymer-geldanamycin derivative conjugates.
Pharmaceutical research 2002;19(2):115-23.
2002: Lu Zheng-Rong; Shiah Jane-Guo; Sakuma Shinji; Kopecková Pavla; Kopecek Jindrich
Design of novel bioconjugates for targeted drug delivery.
Journal of controlled release : official journal of the Controlled Release Society 2002;78(1-3):165-73.
2001: David A; Kopecková P; Rubinstein A; Kopecek J
Enhanced biorecognition and internalization of HPMA copolymers containing multiple or multivalent carbohydrate side-chains by human hepatocarcinoma cells.
Bioconjugate chemistry 2001;12(6):890-9.
2001: Kasuya Y; Lu Z; Kopecková P; Kopecek J
Improved synthesis and evaluation of 17-substituted aminoalkylgeldanamycin derivatives applicable to drug delivery systems.
Bioorganic & medicinal chemistry letters 2001;11(16):2089-91.
2001: Sakuma S; Lu Z R; Kopecková P; Kopecek J
Biorecognizable HPMA copolymer-drug conjugates for colon-specific delivery of 9-aminocamptothecin.
Journal of controlled release : official journal of the Controlled Release Society 2001;75(3):365-79.
2001: Wróblewski S; Berenson M; Kopecková P; Kopecek J
Potential of lectin-N-(2-hydroxypropyl)methacrylamide copolymer-drug conjugates for the treatment of pre-cancerous conditions.
Journal of controlled release : official journal of the Controlled Release Society 2001;74(1-3):283-93.
2001: Tijerina M; Kopecková P; Kopecek J
The effects of subcellular localization of N-(2-hydroxypropyl)methacrylamide copolymer-Mce(6) conjugates in a human ovarian carcinoma.
Journal of controlled release : official journal of the Controlled Release Society 2001;74(1-3):269-73.
2001: Lu Z R; Shiah J G; Kopecková P; Kopecek J
Preparation and biological evaluation of polymerizable antibody Fab' fragment targeted polymeric drug delivery system.
Journal of controlled release : official journal of the Controlled Release Society 2001;74(1-3):263-8.
2001: Shiah J G; Sun Y; Kopecková P; Peterson C M; Straight R C; Kopecek J
Combination chemotherapy and photodynamic therapy of targetable N-(2-hydroxypropyl)methacrylamide copolymer-doxorubicin/mesochlorin e(6)-OV-TL 16 antibody immunoconjugates.
Journal of controlled release : official journal of the Controlled Release Society 2001;74(1-3):249-53.
2001: Kasuya Y; Lu Z R; Kopecková P; Minko T; Tabibi S E; Kopecek J
Synthesis and characterization of HPMA copolymer-aminopropylgeldanamycin conjugates.
Journal of controlled release : official journal of the Controlled Release Society 2001;74(1-3):203-11.
2001: Kopecek J; Kopecková P; Minko T; Lu Z R; Peterson C M
Water soluble polymers in tumor targeted delivery.
Journal of controlled release : official journal of the Controlled Release Society 2001;74(1-3):147-58.
2001: Tang A; Wang C; Stewart R J; Kopecek J
The coiled coils in the design of protein-based constructs: hybrid hydrogels and epitope displays.
Journal of controlled release : official journal of the Controlled Release Society 2001;72(1-3):57-70.
2001: Wróblewski S; Ríhová B; Rossmann P; Hudcovicz T; Reháková Z; Kopecková P; Kopecek J
The influence of a colonic microbiota on HPMA copolymer lectin conjugates binding in rodent intestine.
Journal of drug targeting 2001;9(2):85-94.
2001: Minko T; Kopecková P; Kopecek J
Preliminary evaluation of caspases-dependent apoptosis signaling pathways of free and HPMA copolymer-bound doxorubicin in human ovarian carcinoma cells.
Journal of controlled release : official journal of the Controlled Release Society 2001;71(3):227-37.
2001: Lu Z R; Gao S Q; Kopecková P; Kopecek J
Modification of cyclosporin A and conjugation of its derivative to HPMA copolymers.
Bioconjugate chemistry 2001;12(1):129-33.
2001: Shiah J G; Dvorák M; Kopecková P; Sun Y; Peterson C M; Kopecek J
Biodistribution and antitumour efficacy of long-circulating N-(2-hydroxypropyl)methacrylamide copolymer-doxorubicin conjugates in nude mice.
European journal of cancer (Oxford, England : 1990) 2001;37(1):131-9.
2001: Jensen K D; Kopecková P; Bridge J H; Kopecek J
The cytoplasmic escape and nuclear accumulation of endocytosed and microinjected HPMA copolymers and a basic kinetic study in Hep G2 cells.
AAPS pharmSci 2001;3(4):E32.
2001: Wang C; Kopecek J; Stewart R J
Hybrid hydrogels cross-linked by genetically engineered coiled-coil block proteins.
Biomacromolecules 2001;2(3):912-20.
2001: Fowers K D; Callahan J; Byron P; Kopecek J I
Preparation of Fab' from murine IgG2a for thiol reactive conjugation.
Journal of drug targeting 2001;9(4):281-94.
2000: Tijerina M; Fowers K D; Kopecková P; Kopecek J
Chronic exposure of human ovarian carcinoma cells to free or HPMA copolymer-bound mesochlorin e6 does not induce P-glycoprotein-mediated multidrug resistance.
Biomaterials 2000;21(21):2203-10.
2000: Demoy M; Minko T; Kopecková P; Kopecek J
Time- and concentration-dependent apoptosis and necrosis induced by free and HPMA copolymer-bound doxorubicin in human ovarian carcinoma cells.
Journal of controlled release : official journal of the Controlled Release Society 2000;69(1):185-96.
2000: Chen L; Kopecek J; Stewart R J
Responsive hybrid hydrogels with volume transitions modulated by a titin immunoglobulin module.
Bioconjugate chemistry 2000;11(5):734-40.
2000: Wróblewski S; Berenson M; Kopecková P; Kopecek J
Biorecognition of HPMA copolymer-lectin conjugates as an indicator of differentiation of cell-surface glycoproteins in development, maturation, and diseases of human and rodent gastrointestinal tissues.
Journal of biomedical materials research 2000;51(3):329-42.
2000: Kopecek J; Kopecková P; Minko T; Lu Z
HPMA copolymer-anticancer drug conjugates: design, activity, and mechanism of action.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2000;50(1):61-81.
2000: Minko T; Kopeckova P; Pozharov V; Jensen K D; Kopecek J
The influence of cytotoxicity of macromolecules and of VEGF gene modulated vascular permeability on the enhanced permeability and retention effect in resistant solid tumors.
Pharmaceutical research 2000;17(5):505-14.
2000: Tang A; Wang C; Stewart R; Kopecek J
Self-assembled peptides exposing epitopes recognizable by human lymphoma cells.
Bioconjugate chemistry 2000;11(3):363-71.
2000: Minko T; Kopecková P; Kopecek J
Efficacy of the chemotherapeutic action of HPMA copolymer-bound doxorubicin in a solid tumor model of ovarian carcinoma.
International journal of cancer. Journal international du cancer 2000;86(1):108-17.
2000: Shiah J G; Sun Y; Peterson C M; Straight R C; Kopecek J
Antitumor activity of N-(2-hydroxypropyl) methacrylamide copolymer-Mesochlorine e6 and adriamycin conjugates in combination treatments.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(3):1008-15.
2000: Lu Z R; Gao S Q; Kopecková P; Kopecek J
Synthesis of bioadhesive lectin-HPMA copolymer-cyclosporin conjugates.
Bioconjugate chemistry 2000;11(1):3-7.
2000: Kunath K; Kopecková P; Minko T; Kopecek J
HPMA copolymer-anticancer drug-OV-TL16 antibody conjugates. 3. The effect of free and polymer-bound adriamycin on the expression of some genes in the OVCAR-3 human ovarian carcinoma cell line.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2000;49(1):11-5.
2000: Wang D; Kopecková J P; Minko T; Nanayakkara V; Kopecek J
Synthesis of starlike N-(2-hydroxypropyl)methacrylamide copolymers: potential drug carriers.
Biomacromolecules 2000;1(3):313-9.
2000: Hart P R; Kopecková P; Omelyanenko V; Enioutina E; Kopecek J
HPMA copolymer-modified avidin: immune response.
Journal of biomaterials science. Polymer edition 2000;11(1):1-12.
1999: Shiah J J; Sun Y; Peterson C M; Kopecek J
Biodistribution of free and N-(2-hydroxypropyl)methacrylamide copolymer-bound mesochlorin e(6) and adriamycin in nude mice bearing human ovarian carcinoma OVCAR-3 xenografts.
Journal of controlled release : official journal of the Controlled Release Society 1999;61(1-2):145-57.
1999: Spikes J D; Shen H R; Kopecková P; Kopecek J
Photodynamic crosslinking of proteins. III. Kinetics of the FMN- and rose bengal-sensitized photooxidation and intermolecular crosslinking of model tyrosine-containing N-(2-hydroxypropyl)methacrylamide copolymers.
Photochemistry and photobiology 1999;70(2):130-7.
1999: Dvorák M; Kopecková P; Kopecek J
High-molecular weight HPMA copolymer-adriamycin conjugates.
Journal of controlled release : official journal of the Controlled Release Society 1999;60(2-3):321-32.
1999: Omelyanenko V; Kopecková P; Prakash R K; Ebert C D; Kopecek J
Biorecognition of HPMA copolymer-adriamycin conjugates by lymphocytes mediated by synthetic receptor binding epitopes.
Pharmaceutical research 1999;16(7):1010-9.
1999: Minko T; Kopecková P; Kopecek J
Comparison of the anticancer effect of free and HPMA copolymer-bound adriamycin in human ovarian carcinoma cells.
Pharmaceutical research 1999;16(7):986-96.
1999: Lu J M; Peterson C M; Guo-Shiah J; Gu Z W; Peterson C A; Straight R C; Kopecek J
Cooperativity between free and N-(2-hydroxypropyl) methacrylamide copolymer bound adriamycin and meso-chlorin e6 monoethylene diamine induced photodynamic therapy in human epithelial ovarian carcinoma in vitro.
International journal of oncology 1999;15(1):5-16.
1999: Minko T; Kopecková P; Kopecek J
Chronic exposure to HPMA copolymer-bound adriamycin does not induce multidrug resistance in a human ovarian carcinoma cell line.
Journal of controlled release : official journal of the Controlled Release Society 1999;59(2):133-48.
1999: Lu R H; Kopecková P; Kopecek J
Degradation and aggregation of human calcitonin in vitro.
Pharmaceutical research 1999;16(3):359-67.
1999: Wang C; Stewart R J; Kopecek J
Hybrid hydrogels assembled from synthetic polymers and coiled-coil protein domains.
Nature 1999;397(6718):417-20.
1998: Lu Z R; Kopecková P; Wu Z; Kopecek J
Functionalized semitelechelic poly[N-(2-hydroxypropyl)methacrylamide] for protein modification.
Bioconjugate chemistry 1998;9(6):793-804.
1998: Minko T; Kopecková P; Pozharov V; Kopecek J
HPMA copolymer bound adriamycin overcomes MDR1 gene encoded resistance in a human ovarian carcinoma cell line.
Journal of controlled release : official journal of the Controlled Release Society 1998;54(2):223-33.
1998: Akala E O; Kopecková P; Kopecek J
Novel pH-sensitive hydrogels with adjustable swelling kinetics.
Biomaterials 1998;19(11-12):1037-47.
1998: Omelyanenko V; Kopecková P; Gentry C; Kopecek J
Targetable HPMA copolymer-adriamycin conjugates. Recognition, internalization, and subcellular fate.
Journal of controlled release : official journal of the Controlled Release Society 1998;53(1-3):25-37.
1998: Omelyanenko V; Gentry C; Kopecková P; Kopecek J
HPMA copolymer-anticancer drug-OV-TL16 antibody conjugates. II. Processing in epithelial ovarian carcinoma cells in vitro.
International journal of cancer. Journal international du cancer 1998;75(4):600-8.
1997: Ghandehari H; Kopecková P; Kopecek J
In vitro degradation of pH-sensitive hydrogels containing aromatic azo bonds.
Biomaterials 1997;18(12):861-72.
1997: Chiu H C; Kopecková P; Deshmane S S; Kopecek J
Lysosomal degradability of poly(alpha-amino acids).
Journal of biomedical materials research 1997;34(3):381-92.
1996: Shen H R; Spikes J D; Kopecková P; Kopecek J
Photodynamic crosslinking of proteins. II. Photocrosslinking of a model protein-ribonuclease A.
Journal of photochemistry and photobiology. B, Biology 1996;35(3):213-9.
1996: Putnam D A; Shiah J G; Kopecek J
Intracellularly biorecognizable derivatives of 5-fluorouracil. Implications for site-specific delivery in the human condition.
Biochemical pharmacology 1996;52(6):957-62.
1996: Peterson C M; Lu J M; Sun Y; Peterson C A; Shiah J G; Straight R C; Kopecek J
Combination chemotherapy and photodynamic therapy with N-(2-hydroxypropyl) methacrylamide copolymer-bound anticancer drugs inhibit human ovarian carcinoma heterotransplanted in nude mice.
Cancer research 1996;56(17):3980-5.
1996: Shen H R; Spikes J D; Kopeceková P; Kopecek J
Photodynamic crosslinking of proteins. I. Model studies using histidine- and lysine-containing N-(2-hydroxypropyl)methacrylamide copolymers.
Journal of photochemistry and photobiology. B, Biology 1996;34(2-3):203-10.
1996: Omelyanenko V; Kopecková P; Gentry C; Shiah J G; Kopecek J
HPMA copolymer-anticancer drug-OV-TL16 antibody conjugates. 1. influence of the method of synthesis on the binding affinity to OVCAR-3 ovarian carcinoma cells in vitro.
Journal of drug targeting 1996;3(5):357-73.
1995: Peterson C M; Lu J M; Gu Z W; Shiah J G; Lythgoe K; Peterson C A; Straight R C; Kopecek J
Isobolographic assessment of the interaction between adriamycin and photodynamic therapy with meso-chlorin e6 monoethylene diamine in human epithelial ovarian carcinoma (OVCAR-3) in vitro.
Journal of the Society for Gynecologic Investigation 1995;2(6):772-7.
1995: Putnam D; Kopecek J
Enantioselective release of 5-fluorouracil from N-(2-hydroxypropyl)methacrylamide-based copolymers via lysosomal enzymes.
Bioconjugate chemistry 1995;6(4):483-92.
1995: Kamei S; Kopecek J
Prolonged blood circulation in rats of nanospheres surface-modified with semitelechelic poly[N-(2-hydroxypropyl)methacrylamide].
Pharmaceutical research 1995;12(5):663-8.
1995: Ríhová B; Rathi R C; Kopecková P; Kopecek J
Bioadhesive polymers for oral drug delivery.
Advances in experimental medicine and biology 1995;371B():1491-4.
1994: Yen H R; Oscarsson S; Ulbrich K; Kopecek J
Adsorption and activation of zymogens at solid-liquid interfaces. I. Chymotrypsinogen on alkylamino modified silica derivatives.
Journal of biomedical materials research 1994;28(2):247-57.
1994: Krinick N L; Sun Y; Joyner D; Spikes J D; Straight R C; Kopecek J
A polymeric drug delivery system for the simultaneous delivery of drugs activatable by enzymes and/or light.
Journal of biomaterials science. Polymer edition 1994;5(4):303-24.
1993: Chiu H C; Zalipsky S; Kopecková P; Kopecek J
Enzymatic activity of chymotrypsin and its poly(ethylene glycol) conjugates toward low and high molecular weight substrates.
Bioconjugate chemistry 1993;4(4):290-5.
1992: Brøndsted H; Kopecek J
Hydrogels for site-specific drug delivery to the colon: in vitro and in vivo degradation.
Pharmaceutical research 1992;9(12):1540-5.
1991: Brøndsted H; Kopecek J
Hydrogels for site-specific oral drug delivery: synthesis and characterization.
Biomaterials 1991;12(6):584-92.
1991: Kopecek J
Targetable polymeric anticancer drugs. Temporal control of drug activity.
Annals of the New York Academy of Sciences 1991;618():335-44.
1990: Lee J H; Kopeckova P; Kopecek J; Andrade J D
Surface properties of copolymers of alkyl methacrylates with methoxy (polyethylene oxide) methacrylates and their application as protein-resistant coatings.
Biomaterials 1990;11(7):455-64.
1990: Seymour L W; Ulbrich K; Strohalm J; Kopecek J; Duncan R
The pharmacokinetics of polymer-bound adriamycin.
Biochemical pharmacology 1990;39(6):1125-31.
1990: Subr V; Duncan R; Kopecek J
Release of macromolecules and daunomycin from hydrophilic gels containing enzymatically degradable bonds.
Journal of biomaterials science. Polymer edition 1990;1(4):261-78.
1989: Flanagan P A; Kopecková P; Kopecek J; Duncan R
Evaluation of protein-N-(2-hydroxypropyl)methacrylamide copolymer conjugates as targetable drug carriers. 1. Binding, pinocytic uptake and intracellular distribution of transferrin and anti-transferrin receptor antibody conjugates.
Biochimica et biophysica acta 1989;993(1):83-91.
1989: O'Hare K B; Hume I C; Scarlett L; Chytrý V; Kopecková P; Kopecek J; Duncan R
Effect of galactose on interaction of N-(2-hydroxypropyl)methacrylamide copolymers with hepatoma cells in culture: preliminary application to an anticancer agent, daunomycin.
Hepatology (Baltimore, Md.) 1989;10(2):207-14.
1989: Rihova B; Bilej M; Vetvicka V; Ulbrich K; Strohalm J; Kopecek J; Duncan R
Biocompatibility of N-(2-hydroxypropyl) methacrylamide copolymers containing adriamycin. Immunogenicity, and effect on haematopoietic stem cells in bone marrow in vivo and mouse splenocytes and human peripheral blood lymphocytes in vitro.
Biomaterials 1989;10(5):335-42.
1989: Cassidy J; Duncan R; Morrison G J; Strohalm J; Plocova D; Kopecek J; Kaye S B
Activity of N-(2-hydroxypropyl)methacrylamide copolymers containing daunomycin against a rat tumour model.
Biochemical pharmacology 1989;38(6):875-9.
1989: Lee J H; Kopecek J; Andrade J D
Protein-resistant surfaces prepared by PEO-containing block copolymer surfactants.
Journal of biomedical materials research 1989;23(3):351-68.
1988: Duncan R; Kopecková P; Strohalm J; Hume I C; Lloyd J B; Kopecek J
Anticancer agents coupled to N-(2-hydroxypropyl)methacrylamide copolymers. II. Evaluation of daunomycin conjugates in vivo against L1210 leukaemia.
British journal of cancer 1988;57(2):147-56.
1988: Andrade J D; Herron J; Lin J N; Yen H; Kopecek J; Kopeckova P
On-line sensors for coagulation proteins: concept and progress report.
Biomaterials 1988;9(1):76-9.
1988: Ríhová B; Kopecková P; Strohalm J; Rossmann P; Vetvicka V; Kopecek J
Antibody-directed affinity therapy applied to the immune system: in vivo effectiveness and limited toxicity of daunomycin conjugated to HPMA copolymers and targeting antibody.
Clinical immunology and immunopathology 1988;46(1):100-14.
1987: Seymour L W; Duncan R; Kopecková P; Kopecek J
Daunomycin- and adriamycin-N-(2-hydroxypropyl)methacrylamide copolymer conjugates; toxicity reduction by improved drug-delivery.
Cancer treatment reviews 1987;14(3-4):319-27.
1987: Seymour L W; Duncan R; Strohalm J; Kopecek J
Effect of molecular weight (Mw) of N-(2-hydroxypropyl)methacrylamide copolymers on body distribution and rate of excretion after subcutaneous, intraperitoneal, and intravenous administration to rats.
Journal of biomedical materials research 1987;21(11):1341-58.
1987: Duncan R; Kopecková-Rejmanová P; Strohalm J; Hume I; Cable H C; Pohl J; Lloyd J B; Kopecek J
Anticancer agents coupled to N-(2-hydroxypropyl)methacrylamide copolymers. I. Evaluation of daunomycin and puromycin conjugates in vitro.
British journal of cancer 1987;55(2):165-74.
1986: Duncan R; Cable H C; Strohalm J; Kopecek J
Pinocytic capture and exocytosis of rat immunoglobulin IgG-N-(2-hydroxypropyl)methacrylamide copolymer conjugates by rat visceral yolk sacs cultured in vitro.
Bioscience reports 1986;6(10):869-77.
1986: Vetvicka V; Fornusek L; Kincade P W; Kopecek J
Co-expression of different types of Fc receptors on murine peritoneal macrophages.
European journal of immunology 1986;16(8):901-5.
1986: Tlaskalová-Hogenová H; Vetvicka V; Pospísil M; Fornusek L; Prokesova L; Coupek J; Frydrychová A; Kopecek J; Fiebig H; Brochier J
Separation of human lymphoid cells by affinity chromatography and cell surface labelling by hydroxyethyl methacrylate particles using monoclonal antibodies.
Journal of chromatography 1986;376():401-8.
1986: Ríhová B; Kopecek J; Kopecková-Rejmanová P; Strohalm J; Plocová D; Semorádová H
Bioaffinity therapy with antibodies and drugs bound to soluble synthetic polymers.
Journal of chromatography 1986;376():221-33.
1986: Duncan R; Seymour L C; Scarlett L; Lloyd J B; Rejmanová P; Kopecek J
Fate of N-(2-hydroxypropyl)methacrylamide copolymers with pendent galactosamine residues after intravenous administration to rats.
Biochimica et biophysica acta 1986;880(1):62-71.
1985: Rejmanová P; Kopecek J; Duncan R; Lloyd J B
Stability in rat plasma and serum of lysosomally degradable oligopeptide sequences in N-(2-hydroxypropyl) methacrylamide copolymers.
Biomaterials 1985;6(1):45-8.
1985: Vetvicka V; Fornusek L; Ríhová B; Kopecek J
Properties of macrophages from low- and high-responder strains of mice. I. Effect of antigenic stimulation.
Folia biologica 1985;31(1):20-33.
1985: Kopecek J; Rejmanová P; Duncan R; Lloyd J B
Controlled release of drug model from N-(2-hydroxypropyl)-methacrylamide copolymers.
Annals of the New York Academy of Sciences 1985;446():93-104.
1984: Vetvicka V; Fornusek L; Holub M; Zídková J; Kopecek J
Macrophages of athymic nude mice: Fc receptors, C receptors, phagocytic and pinocytic activities.
European journal of cell biology 1984;35(1):35-40.
1984: Rihová B; Kopecek J; Ulbrich K; Pospisil M; Mancal P
Effect of the chemical structure of N-(2-hydroxypropyl)methacrylamide copolymers on their ability to induce antibody formation in inbred strains of mice.
Biomaterials 1984;5(3):143-8.
1984: Duncan R; Cable H C; Rejmanová P; Kopecek J; Lloyd J B
Tyrosinamide residues enhance pinocytic capture of N-(2-hydroxypropyl)methacrylamide copolymers.
Biochimica et biophysica acta 1984;799(1):1-8.
1983: Duncan R; Kopecek J; Rejmanová P; Lloyd J B
Targeting of N-(2-hydroxypropyl)methacrylamide copolymers to liver by incorporation of galactose residues.
Biochimica et biophysica acta 1983;755(3):518-21.
1983: Solovskij M V; Ulbrich K; Kopecek J
Synthesis of N-(2-hydroxypropyl)methacrylamide copolymers with antimicrobial activity.
Biomaterials 1983;4(1):44-8.
1983: Ríhová B; Ulbrich K; Kopecek J; Mancal P
Immunogenicity of N-(2-hydroxypropyl)-methacrylamide copolymers--potential hapten or drug carriers.
Folia microbiologica 1983;28(3):217-27.
1983: Vetvicka V; Fornusek L; Kopecek J; Prikrylová D
Phagocytosis of 2-hydroxyethylmethacrylate copolymer particles by different types of macrophages.
Folia biologica 1983;29(6):424-8.
1983: Fornusek L; Kopecek J; Vetvicka V
An advantageous method for detection of Fc-receptors and for studying Fc-receptor-mediated phagocytosis.
Immunology letters 1983;7(1):29-33.
1982: Duncan R; Cable H C; Lloyd J B; Rejmanová P; Kopecek J
Degradation of side-chains of N-(2-hydroxypropyl)methacrylamide copolymers by lysosomal thiol-proteinases.
Bioscience reports 1982;2(12):1041-6.
1982: Vetvicka V; Fornusek L; Kopecek J; Kamínková J; Kaspárek L; Vránová M
Phagocytosis of human blood leukocytes: a simple micromethod.
Immunology letters 1982;5(2):97-100.
1982: Ulbrich K; Strohalm J; Kopecek J
Polymers containing enzymatically degradable bonds. VI. Hydrophilic gels cleavable by chymotrypsin.
Biomaterials 1982;3(3):150-4.
1980: Ulbrich K; Zacharieva E I; Obereigner B; Kopecek J
Polymers containing enzymatically degradable bonds V. Hydrophilic polymers degradable by papain.
Biomaterials 1980;1(4):199-204.

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