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Libor Kopkan

Research Profile

Living Beings

Disorders

Anatomy

Kidneys

Chemicals & Drugs

Physiology

Glomerular Filtration Rate

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Renal Circulation

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Publications

TOP 3
Zuzana Honetschlägerová; Zuzana Husková; Sung Hee Hwang; John D Imig; Kento Kitada; Libor Kopkan; Herbert kramer; Petr Kujal; Akira Nishiyama; Alexandra Sporková; Šárka Varcabová; Zdena Vernerová; Marcela Bürgelová; Bruce D Hammock; Ludek Cervenka
Antihypertensive and renoprotective actions of soluble epoxide hydrolase inhibition in ANG II-dependent malignant hypertension are abolished by pretreatment with L-NAME.
Jan Neckář; Ivan Netuka; Bohuslav Ošťádal; František Papoušek; Bruce D Hammock; Zuzana Husková; Sung Hee Hwang; John D Imig; František Kolář; Libor Kopkan; Herbert J Kramer; Jiří Malý; Ludek Cervenka
Inhibition of soluble epoxide hydrolase by cis-4-[4-(3-adamantan-1-ylureido)cyclohexyl-oxy]benzoic acid exhibits antihypertensive and cardioprotective actions in transgenic rats with angiotensin II-dependent hypertension.
Libor Kopkan; Herbert kramer; Petr Kujal; Alexandra Sporková; Hsing-Ju Tsai; Zdena Vernerová; Alžběta Vojtíšková; Marcela Bürgelová; Bruce D Hammock; Zuzana Honetschlägerová; Zuzana Husková; Sung Hee Hwang; John D Imig; Šárka Varcabová; Ludek Cervenka
Soluble epoxide hydrolase inhibition exhibits antihypertensive actions independently of nitric oxide in mice with renovascular hypertension.

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All Publications

2013: Zuzana Honetschlägerová; Zuzana Husková; Sung Hee Hwang; John D Imig; Kento Kitada; Libor Kopkan; Herbert kramer; Petr Kujal; Akira Nishiyama; Alexandra Sporková; Šárka Varcabová; Zdena Vernerová; Marcela Bürgelová; Bruce D Hammock; Ludek Cervenka
Antihypertensive and renoprotective actions of soluble epoxide hydrolase inhibition in ANG II-dependent malignant hypertension are abolished by pretreatment with L-NAME.
Journal of hypertension 2013;31(2):321-32.
2012: Jan Neckář; Ivan Netuka; Bohuslav Ošťádal; František Papoušek; Bruce D Hammock; Zuzana Husková; Sung Hee Hwang; John D Imig; František Kolář; Libor Kopkan; Herbert J Kramer; Jiří Malý; Ludek Cervenka
Inhibition of soluble epoxide hydrolase by cis-4-[4-(3-adamantan-1-ylureido)cyclohexyl-oxy]benzoic acid exhibits antihypertensive and cardioprotective actions in transgenic rats with angiotensin II-dependent hypertension.
Clinical science (London, England : 1979) 2012;122(11):513-25.
2012: Libor Kopkan; Herbert kramer; Petr Kujal; Alexandra Sporková; Hsing-Ju Tsai; Zdena Vernerová; Alžběta Vojtíšková; Marcela Bürgelová; Bruce D Hammock; Zuzana Honetschlägerová; Zuzana Husková; Sung Hee Hwang; John D Imig; Šárka Varcabová; Ludek Cervenka
Soluble epoxide hydrolase inhibition exhibits antihypertensive actions independently of nitric oxide in mice with renovascular hypertension.
Kidney & blood pressure research 2012;35(6):595-607.
2012: Vojtech Melenovsky; Petra Skaroupkova; Vera Torresova; Jan Benes; Libor Kopkan; Ludek Cervenka
The course of heart failure development and mortality in rats with volume overload due to aorto-caval fistula.
Kidney & blood pressure research 2012;35(3):167-73.
2011: Zuzana Honetschlägerová; Zuzana Husková; Sung H Hwang; John D Imig; Libor Kopkan; Herbert J Kramer; Petr Kujal; Alexandra Sporková; Vladimír Tesař; Zdena Vernerová; Vera Certíková Chábová; Bruce D Hammock; Ludek Cervenka
Inhibition of soluble epoxide hydrolase improves the impaired pressure-natriuresis relationship and attenuates the development of hypertension and hypertension-associated end-organ damage in Cyp1a1-Ren-2 transgenic rats.
Journal of hypertension 2011;29(8):1590-601.
2011: Alexandra Sporková; Sárka Varcabová; Bruce D Hammock; Zuzana Husková; Sung Hee Hwang; John D Imig; Libor Kopkan; Herbert J Kramer; Ludek Cervenka
Role of cytochrome P-450 metabolites in the regulation of renal function and blood pressure in 2-kidney 1-clip hypertensive rats.
American journal of physiology. Regulatory, integrative and comparative physiology 2011;300(6):R1468-75.
2011: Zuzana Dzirbíková; Alexander Kiss; Monika Okuliarová; Libor Kopkan; Ludĕk Cervenka
Expressions of per1 clock gene and genes of signaling peptides vasopressin, vasoactive intestinal peptide, and oxytocin in the suprachiasmatic and paraventricular nuclei of hypertensive TGR[mREN2]27 rats.
Cellular and molecular neurobiology 2011;31(2):225-32.
2011: Zuzana Honetschlägerová; Zuzana Z Husková; Zdeňka Vaňourková; Alexandra Sporková; Herbert J Kramer; Sung Hee Hwang; Hsing-Ju Tsai; Bruce D Hammock; John D Imig; Luděk Červenka; Libor Kopkan
Renal mechanisms contributing to the antihypertensive action of soluble epoxide hydrolase inhibition in Ren-2 transgenic rats with inducible hypertension.
The Journal of physiology 2011;589(Pt 1):207-19.
2010: Petr Kujal; Věra Čertíková Chábová; Zdena Vernerová; Agnieszka Walkowska; Elzbieta Kompanowska-Jezierska; Janusz Sadowski; Zdeňka Vaňourková; Zuzana Husková; Martin Opočenský; Petra Skaroupková; Stanislava Schejbalová; Herbert J Kramer; Dan Rakušan; Jan Malý; Ivan Netuka; Ivana Vaněčková; Libor Kopkan; Ludek Cervenka
Similar renoprotection after renin-angiotensin-dependent and -independent antihypertensive therapy in 5/6-nephrectomized Ren-2 transgenic rats: are there blood pressure-independent effects?
Clinical and experimental pharmacology & physiology 2010;37(12):1159-69.
2010: Libor Kopkan; Arthur Hess; Zuzana Husková; Ludek Cervenka; L Gabriel Navar; Dewan S A Majid
High-salt intake enhances superoxide activity in eNOS knockout mice leading to the development of salt sensitivity.
American journal of physiology. Renal physiology 2010;299(3):F656-63.
2010: Vera Certíková Chábová; Agnieszka Walkowska; Elzbieta Kompanowska-Jezierska; Janusz Sadowski; Petr Kujal; Zdenka Vernerová; Zdena Vanourková; Libor Kopkan; Herbert kramer; John R Falck; John D Imig; Bruce D Hammock; Ivana Vanecková; Ludek Cervenka
Combined inhibition of 20-hydroxyeicosatetraenoic acid formation and of epoxyeicosatrienoic acids degradation attenuates hypertension and hypertension-induced end-organ damage in Ren-2 transgenic rats.
Clinical science (London, England : 1979) 2010;118(10):617-32.
2010: Jan Sochman; Jan H Peregrin; Marcela Bürgelová; Libor Kopkan; Herbert kramer; Ludek Cervenka
N-acetylcysteine attenuates iodine contrast agent-induced nephropathy in 5/6-nephrectomized rats.
Kidney & blood pressure research 2010;33(2):149-56.
2009: Libor Kopkan; Md Abdul H Khan; Agnieszka Lis; Mouhamed S Awayda; Dewan S A Majid
Cholesterol induces renal vasoconstriction and anti-natriuresis by inhibiting nitric oxide production in anesthetized rats.
American journal of physiology. Renal physiology 2009;297(6):F1606-13.
2009: Libor Kopkan; Zuzana Husková; Zdenka Vanourková; Monika Thumová; Petra Skaroupková; Jan Malý; Herbert kramer; Petr Dvorák; Ludek Cervenka
Reduction of oxidative stress does not attenuate the development of angiotensin II-dependent hypertension in Ren-2 transgenic rats.
Vascular pharmacology 2009;51(2-3):175-81.
2007: Libor Kopkan; Zuzana Husková; Zdenka Vanourková; Monika Thumová; Petra Skaroupková; Ludek Cervenka; Dewan S A Majid
Superoxide and its interaction with nitric oxide modulates renal function in prehypertensive Ren-2 transgenic rats.
Journal of hypertension 2007;25(11):2257-65.
2007: Dewan S A Majid; Libor Kopkan
Nitric oxide and superoxide interactions in the kidney and their implication in the development of salt-sensitive hypertension.
Clinical and experimental pharmacology & physiology 2007;34(9):946-52.
2007: Ivana Vanecková; Libor Kopkan; Zuzana Husková; Zdenka Vanourková; Stanislava Schejbalová; Ludek Cervenka; Herbert kramer
AT1 receptor antisense therapy transiently lowers blood pressure in Ren-2 transgenic rats.
Vascular pharmacology 2007;47(1):63-7.
2007: Ivana Vanecková; Libor Kopkan; Zuzana Husková; Zdenka Vanourková; Stanislava Schejbalová; Ludek Cervenka; Herbert kramer
Long-term prevention of hypertension and end-organ damage in Ren-2 transgenic rats is achieved only with persistent but not transient AT1 receptor blockade.
Kidney & blood pressure research 2007;30(1):38-44.
2006: Libor Kopkan; Dewan S A Majid
Enhanced superoxide activity modulates renal function in NO-deficient hypertensive rats.
Hypertension 2006;47(3):568-72.
2006: Libor Kopkan; Alexander Castillo; L Gabriel Navar; Dewan S A Majid
Enhanced superoxide generation modulates renal function in ANG II-induced hypertensive rats.
American journal of physiology. Renal physiology 2006;290(1):F80-6.
2005: Libor Kopkan; Dewan S A Majid
Superoxide contributes to development of salt sensitivity and hypertension induced by nitric oxide deficiency.
Hypertension 2005;46(4):1026-31.
2005: Libor Kopkan; Herbert kramer; Zuzana Husková; Zdenka Vanourková; Petra Skaroupková; Monika Thurmová; Ludek Cervenka
The role of intrarenal angiotensin II in the development of hypertension in Ren-2 transgenic rats.
Journal of hypertension 2005;23(8):1531-9.
2004: Libor Kopkan; Herbert kramer; Zuzana Husková; Zdenka Vanourková; Angela Bäcker; Michael Bader; Detlev Ganten; Ludek Cervenka
Plasma and kidney angiotensin II levels and renal functional responses to AT(1) receptor blockade in hypertensive Ren-2 transgenic rats.
Journal of hypertension 2004;22(4):819-25.
2004: Martin Opocenský; Petr Dvorák; Jan Malý; Herbert kramer; Angela Bäcker; Libor Kopkan; Zdena Vernerová; Vladimír Tesar; Tomáš Zima; Michael Bader; Detlev Ganten; J Janda; Ivana Vanecková
Chronic endothelin receptor blockade reduces end-organ damage independently of blood pressure effects in salt-loaded heterozygous Ren-2 transgenic rats.
Physiological research / Academia Scientiarum Bohemoslovaca 2004;53(6):581-93.
2004: Petr Dvorák; Herbert kramer; Angela Bäcker; Jan Malý; Libor Kopkan; Ivana Vanecková; Zdena Vernerová; Martin Opocenský; Vladimír Tesar; Michael Bader; Detlev Ganten; Jan Janda; Ludek Cervenka
Blockade of endothelin receptors attenuates end-organ damage in homozygous hypertensive ren-2 transgenic rats.
Kidney & blood pressure research 2004;27(4):248-58.