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Kenneth Korach

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Wipawee Winuthayanon; Lars C Pedersen; Pawinee Piyachaturawat; Apichart Suksamrarn; Yukitomo Arao; Katherine A Burns; Sylvia Curtis Hewitt; Kenneth S Korach
The natural estrogenic compound diarylheptanoid (D3): in vitro mechanisms of action and in vivo uterine responses via estrogen receptor α.
Yin Li; Colin J Luh; Christina T Teng; Raymond R Tice; Yukitomo Arao; Katherine A Burns; Zhongliang Jiang; Kenneth S Korach
Endocrine-Disrupting Chemicals (EDCs): In Vitro Mechanism of Estrogenic Activation and Differential Effects on ER Target Genes.
Sang-Hyuk Chung; Kenneth S Korach; Myeong-Kyun Shin; Paul F Lambert
Requirement for stromal estrogen receptor alpha in cervical neoplasia.

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2013: Wipawee Winuthayanon; Lars C Pedersen; Pawinee Piyachaturawat; Apichart Suksamrarn; Yukitomo Arao; Katherine A Burns; Sylvia Curtis Hewitt; Kenneth S Korach
The natural estrogenic compound diarylheptanoid (D3): in vitro mechanisms of action and in vivo uterine responses via estrogen receptor α.
Environmental health perspectives 2013;121(4):433-9, 439e1-5.
2013: Yin Li; Colin J Luh; Christina T Teng; Raymond R Tice; Yukitomo Arao; Katherine A Burns; Zhongliang Jiang; Kenneth S Korach
Endocrine-Disrupting Chemicals (EDCs): In Vitro Mechanism of Estrogenic Activation and Differential Effects on ER Target Genes.
Environmental health perspectives 2013;121(4):459-66, 466e1-6.
2013: Sang-Hyuk Chung; Kenneth S Korach; Myeong-Kyun Shin; Paul F Lambert
Requirement for stromal estrogen receptor alpha in cervical neoplasia.
Hormones & cancer 2013;4(1):50-9.
2012: Yukitomo Arao; Edward M Eddy; Eugenia H Goulding; Katherine J Hamilton; Kyathanahalli S Janardhan; Kenneth S Korach
Transactivating function (AF) 2-mediated AF-1 activity of estrogen receptor α is crucial to maintain male reproductive tract function.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(51):21140-5.
2012: Martin Kavaliers; Kenneth S Korach; Louis Muglia; Amy Clipperton-Allen; Cheryl L Cragg; Jan-Åke Gustafsson; Elena Choleris
Male risk taking, female odors, and the role of estrogen receptors.
Physiology & behavior 2012;107(5):751-61.
2012: Paula Anahi Arias-Loza; Barbara Bayer; Stefan Frantz; Karl-Heinrich Fritzemeier; Kai Hu; Ina Israel; Franz R Kaiser; Susanne Kneitz; Kenneth S Korach; Michael C Kreissl; Theo Pelzer
The estrogen receptor-α is required and sufficient to maintain physiological glucose uptake in the mouse heart.
Hypertension 2012;60(4):1070-7.
2012: Katherine A Burns; Kenneth S Korach
Estrogen receptors and human disease: an update.
Archives of toxicology 2012;86(10):1491-504.
2012: Yin Li; Colin J Luh; Yukitomo Arao; Katherine A Burns; Kenneth S Korach
Differential estrogenic actions of endocrine-disrupting chemicals bisphenol A, bisphenol AF, and zearalenone through estrogen receptor α and β in vitro.
Environmental health perspectives 2012;120(7):1029-35.
2012: Ayesha Joshi; Kenneth S Korach; Hong Wang; Joanna S Y Chan; Wayne Douglas; Gaofeng Jiang; Lora Hedrick Ellenson
Endometrial tumorigenesis in Pten(+/-) mice is independent of coexistence of estrogen and estrogen receptor α.
The American journal of pathology 2012;180(6):2536-47.
2012: Sylvia C Hewitt; Leping Li; Yin Li; Liwen Liu; Pierre R Bushel; Yu Chen; David Fargo; Sara A Grimm; Kenneth S Korach
Research resource: whole-genome estrogen receptor α binding in mouse uterine tissue revealed by ChIP-seq.
Molecular endocrinology (Baltimore, Md.) 2012;26(5):887-98.
2012: Vickie R Walker; John F Couse; Wendy N Jefferson; Kenneth S Korach
Estrogen receptor-α mediates diethylstilbestrol-induced feminization of the seminal vesicle in male mice.
Environmental health perspectives 2012;120(4):560-5.
2011: Sarah Hart-Unger; Kenneth S Korach
Estrogens and obesity: is it all in our heads?
Cell metabolism 2011;14(4):435-6.
2011: Yukitomo Arao; Katherine J Hamilton; Yuji Mishina; Manas K Ray; Gregory Scott; Kenneth S Korach
Estrogen receptor α AF-2 mutation results in antagonist reversal and reveals tissue selective function of estrogen receptor modulators.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(36):14986-91.
2011: Sylvia Curtis Hewitt; Kenneth S Korach
Cell biology. A hand to support the implantation window.
Science (New York, N.Y.) 2011;331(6019):863-4.
2011: Sylvia C Hewitt; Kenneth S Korach
Estrogenic activity of bisphenol A and 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane (HPTE) demonstrated in mouse uterine gene profiles.
Environmental health perspectives 2011;119(1):63-70.
2010: Eugenia H Goulding; Sylvia Curtis Hewitt; Noriko Nakamura; Katherine Hamilton; Kenneth S Korach; Edward M Eddy
Ex3αERKO male infertility phenotype recapitulates the αERKO male phenotype.
The Journal of endocrinology 2010;207(3):281-8.
2010: Sylvia C Hewitt; Grace E Kissling; Karen E Fieselman; Friederike L Jayes; Kevin E Gerrish; Kenneth S Korach
Biological and biochemical consequences of global deletion of exon 3 from the ER alpha gene.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010;24(12):4660-7.
2010: Wipawee Winuthayanon; Sylvia Curtis Hewitt; Grant D Orvis; Richard R Behringer; Kenneth S Korach
Uterine epithelial estrogen receptor α is dispensable for proliferation but essential for complete biological and biochemical responses.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(45):19272-7.
2010: W Yue; Ji-Ping Wang; Yuebai Li; Ping Fan; Guijian Liu; Nan Zhang; Mark Conaway; Hongkun Wang; Kenneth S Korach; Wayne Bocchinfuso; Richard Santen
Effects of estrogen on breast cancer development: Role of estrogen receptor independent mechanisms.
International journal of cancer. Journal international du cancer 2010;127(8):1748-57.
2010: Winifred P S Wong; Joseph Tiano; Suhuan Liu; Sylvia C Hewitt; Cedric Le May; Stéphane Dalle; John A Katzenellenbogen; Benita S Katzenellenbogen; Kenneth S Korach; Franck Mauvais-Jarvis
Extranuclear estrogen receptor-alpha stimulates NeuroD1 binding to the insulin promoter and favors insulin synthesis.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(29):13057-62.
2010: Derek V Henley; Kenneth S Korach
Physiological effects and mechanisms of action of endocrine disrupting chemicals that alter estrogen signaling.
Hormones (Athens, Greece) 2010;9(3):191-205.
2010: Karina F Rodriguez; John F Couse; Friederike L Jayes; Katherine J Hamilton; Katherine A Burns; Fuminori Taniguchi; Kenneth S Korach
Insufficient luteinizing hormone-induced intracellular signaling disrupts ovulation in preovulatory follicles lacking estrogen receptor-{beta}.
Endocrinology 2010;151(6):2826-34.
2010: Eric P Smith; Bonny Specker; Kenneth S Korach
Recent experimental and clinical findings in the skeleton associated with loss of estrogen hormone or estrogen receptor activity.
The Journal of steroid biochemistry and molecular biology 2010;118(4-5):264-72.
2010: Yukitomo Arao; Karen Carpenter; Sylvia Hewitt; Kenneth S Korach
Estrogen down-regulation of the Scx gene is mediated by the opposing strand-overlapping gene Bop1.
The Journal of biological chemistry 2010;285(7):4806-14.
2010: Sylvia Curtis Hewitt; Yin Li; Leping Li; Kenneth S Korach
Estrogen-mediated regulation of Igf1 transcription and uterine growth involves direct binding of estrogen receptor alpha to estrogen-responsive elements.
The Journal of biological chemistry 2010;285(4):2676-85.
2009: Derek V Henley; Stephanie Mueller; Kenneth S Korach
The short-chain fatty acid methoxyacetic acid disrupts endogenous estrogen receptor-alpha-mediated signaling.
Environmental health perspectives 2009;117(11):1702-6.
2009: Suhuan Liu; Cedric Le May; Winifred P S Wong; Robert D Ward; Deborah J Clegg; Marco Marcelli; Kenneth S Korach; Franck Mauvais-Jarvis
Importance of extranuclear estrogen receptor-alpha and membrane G protein-coupled estrogen receptor in pancreatic islet survival.
Diabetes 2009;58(10):2292-302.
2009: Alicia G Cleveland; Seija I Oikarinen; Kimberly K Bynoté; Maija Marttinen; Joseph Rafter; Jan-Ake Gustafsson; Shyamal K Roy; Henry C Pitot; Kenneth S Korach; Dennis B Lubahn; Marja Mutanen; Karen A Gould
Disruption of estrogen receptor signaling enhances intestinal neoplasia in Apc(Min/+) mice.
Carcinogenesis 2009;30(9):1581-90.
2009: Bonnie J Deroo; Sylvia Curtis Hewitt; Jennifer B Collins; Sherry F Grissom; Katherine J Hamilton; Kenneth S Korach
Profile of estrogen-responsive genes in an estrogen-specific mammary gland outgrowth model.
Molecular reproduction and development 2009;76(8):733-50.
2009: Bonnie J Deroo; Karina F Rodriguez; John F Couse; Katherine J Hamilton; Jennifer B Collins; Sherry F Grissom; Kenneth S Korach
Estrogen receptor beta is required for optimal cAMP production in mouse granulosa cells.
Molecular endocrinology (Baltimore, Md.) 2009;23(7):955-65.
2009: Kazuya Tomihara; Tomoko Soga; Masayoshi Nomura; Kenneth S Korach; Jan-�ke GUSTAFSSON; Donald Pfaff; Sonoko Ogawa
Effect of ER-beta gene disruption on estrogenic regulation of anxiety in female mice.
Physiology & behavior 2009;96(2):300-6.
2008: Sang-Hyuk Chung; Kerri Wiedmeyer; Anny Shai; Kenneth S Korach; Paul F Lambert
Requirement for estrogen receptor alpha in a mouse model for human papillomavirus-associated cervical cancer.
Cancer research 2008;68(23):9928-34.
2008: Jeffrey Weiss; Miranda L Bernhardt; Monica M Laronda; Lisa A Hurley; Christine Glidewell-Kenney; Suresh Pillai; Minghan Tong; Kenneth S Korach; J Larry Jameson
Estrogen actions in the male reproductive system involve estrogen response element-independent pathways.
Endocrinology 2008;149(12):6198-206.
2008: Krairerk Athirakul; J Alyce Bradbury; Joan P Graves; Laura M Degraff; Jixiang Ma; Yun Zhao; John F Couse; Raymond Quigley; David R Harder; Xueying _ Zhao; John D Imig; Theresa L Pedersen; John William Newman; Bruce D Hammock; Alan J Conley; Kenneth S Korach; Thomas M Coffman; Darryl C Zeldin
Increased blood pressure in mice lacking cytochrome P450 2J5.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(12):4096-108.
2008: John L Svenson; Jackie G EuDaly; Phillip Ruiz; Kenneth S Korach; Gary S Gilkeson
Impact of estrogen receptor deficiency on disease expression in the NZM2410 lupus prone mouse.
Clinical immunology (Orlando, Fla.) 2008;128(2):259-68.
2008: Eric P Smith; Bonny Specker; Bert E Bachrach; Kevin Kimbro; X J Li; Marian F Young; Neal S Fedarko; M J Abuzzahab; Graeme Frank; Robert M Cohen; Dennis B Lubahn; Kenneth S Korach
Impact on bone of an estrogen receptor-alpha gene loss of function mutation.
The Journal of clinical endocrinology and metabolism 2008;93(8):3088-96.
2008: James W Voltz; Jeffrey W Card; Michelle A Carey; Laura M Degraff; Catherine D Ferguson; Gordon P Flake; James C Bonner; Kenneth S Korach; Darryl C Zeldin
Male sex hormones exacerbate lung function impairment after bleomycin-induced pulmonary fibrosis.
American journal of respiratory cell and molecular biology 2008;39(1):45-52.
2008: Martin Kavaliers; Nino Devidze; Elena Choleris; Melissa Fudge; Jan-�ke GUSTAFSSON; Kenneth S Korach; Donald Pfaff; Sonoko Ogawa
Estrogen receptors alpha and beta mediate different aspects of the facilitatory effects of female cues on male risk taking.
Psychoneuroendocrinology 2008;33(5):634-42.
2008: Kerstin Sinkevicius; Joanna E Burdette; Karolina Woloszyn; Sylvia C Hewitt; Katherine Hamilton; Sonia L Sugg; Karla A Temple; Fredric E Wondisford; Kenneth S Korach; Teresa K Woodruff; Geoffrey L Greene
An estrogen receptor-alpha knock-in mutation provides evidence of ligand-independent signaling and allows modulation of ligand-induced pathways in vivo.
Endocrinology 2008;149(6):2970-9.
2008: Gail S Prins; Kenneth S Korach
The role of estrogens and estrogen receptors in normal prostate growth and disease.
Steroids 2008;73(3):233-44.
2008: Dianxin Liu; Anne Deschamps; Kenneth S Korach; Elizabeth Murphy
Estrogen-enhanced gene expression of lipoprotein lipase in heart is antagonized by progesterone.
Endocrinology 2008;149(2):711-6.
2007: Michihisa Umetani; Hideharu Domoto; Andrew K Gormley; Ivan S Yuhanna; Carolyn L Cummins; Norman B Javitt; Kenneth S Korach; Philip W Shaul; David J Mangelsdorf
27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen.
Nature medicine 2007;13(10):1185-92.
2007: Michelle A Carey; Jeffrey W Card; James W Voltz; Samuel J Arbes; Dori R Germolec; Kenneth S Korach; Darryl C Zeldin
It's all about sex: gender, lung development and lung disease.
Trends in endocrinology and metabolism: TEM 2007;18(8):308-13.
2007: Michelle A Carey; Jeffrey W Card; James W Voltz; Dori R Germolec; Kenneth S Korach; Darryl C Zeldin
The impact of sex and sex hormones on lung physiology and disease: lessons from animal studies.
American journal of physiology. Lung cellular and molecular physiology 2007;293(2):L272-8.
2007: Angélique Gougelet; Stefan O Mueller; Kenneth S Korach; Jack-Michel Renoir
Oestrogen receptors pathways to oestrogen responsive elements: the transactivation function-1 acts as the keystone of oestrogen receptor (ER)beta-mediated transcriptional repression of ERalpha.
The Journal of steroid biochemistry and molecular biology 2007;104(3-5):110-22.
2007: Jianxun Wang; Kathleen Scully; Xiaoyan Zhu; Ling Cai; Jie Zhang; Gratien Prefontaine; Anna Krones; Kenneth A Ohgi; Ping Zhu; Ivan Garcia-Bassets; Forrest Liu; Havilah Taylor; Jean Lozach; Friederike L Jayes; Kenneth S Korach; Christopher K Glass; Xiang-Dong Fu; Michael G Rosenfeld
Opposing LSD1 complexes function in developmental gene activation and repression programmes.
Nature 2007;446(7138):882-7.
2007: Derek V Henley; Natasha Lipson; Kenneth S Korach; Clifford A Bloch
Prepubertal gynecomastia linked to lavender and tea tree oils.
The New England journal of medicine 2007;356(5):479-85.
2007: Fuminori Taniguchi; John F Couse; Karina F Rodriguez; Judith M A Emmen; Donald Poirier; Kenneth S Korach
Estrogen receptor-alpha mediates an intraovarian negative feedback loop on thecal cell steroidogenesis via modulation of Cyp17a1 (cytochrome P450, steroid 17alpha-hydroxylase/17,20 lyase) expression.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(2):586-95.
2007: Michelle A Carey; Jeffrey W Card; J Alyce Bradbury; Michael P Moorman; Najwa Haykal-Coates; Stephen H Gavett; Joan P Graves; Vickie R Walker; Gordon P Flake; James W Voltz; Daling Zhu; Elizabeth R Jacobs; Azzeddine Dakhama; Gary L Larsen; Joan E Loader; Erwin W Gelfand; Dori R Germolec; Kenneth S Korach; Darryl C Zeldin
Spontaneous airway hyperresponsiveness in estrogen receptor-alpha-deficient mice.
American journal of respiratory and critical care medicine 2007;175(2):126-35.
2006: Karen D Carpenter; Kenneth S Korach
Potential biological functions emerging from the different estrogen receptors.
Annals of the New York Academy of Sciences 2006;1092():361-73.
2006: Karin Dahlman-Wright; Vincent Cavailles; Suzanne A Fuqua; V Craig Jordan; John A Katzenellenbogen; Kenneth S Korach; Adriana Maggi; Masami Muramatsu; Malcolm G Parker; Jan-�ke GUSTAFSSON
International Union of Pharmacology. LXIV. Estrogen receptors.
Pharmacological reviews 2006;58(4):773-81.
2006: Tim M Wintermantel; Rebecca E Campbell; Robert Porteous; Dagmar Bock; Hermann-Josef Gröne; Martin G Todman; Kenneth S Korach; Erich Greiner; Cristian A Pérez; Günther Schütz; Allan E Herbison
Definition of estrogen receptor pathway critical for estrogen positive feedback to gonadotropin-releasing hormone neurons and fertility.
Neuron 2006;52(2):271-80.
2006: Jonathan Lindzey; Friederike L Jayes; Mariana M Yates; John F Couse; Kenneth S Korach
The bi-modal effects of estradiol on gonadotropin synthesis and secretion in female mice are dependent on estrogen receptor-alpha.
The Journal of endocrinology 2006;191(1):309-17.
2006: Jeanne E O'Brien; Theresa J Peterson; Ming Han Tong; Eun Jig Lee; Liza O'Donoghue; Sylvia C Hewitt; Kenneth S Korach; Jeffrey Weiss; J Larry Jameson
Estrogen-induced proliferation of uterine epithelial cells is independent of estrogen receptor alpha binding to classical estrogen response elements.
The Journal of biological chemistry 2006;281(36):26683-92.
2006: John F Couse; Mariana M Yates; Karina F Rodriguez; Jo Anne Johnson; Donald Poirier; Kenneth S Korach
The intraovarian actions of estrogen receptor-alpha are necessary to repress the formation of morphological and functional Leydig-like cells in the female gonad.
Endocrinology 2006;147(8):3666-78.
2006: Kazuya Tomihara; Taku Kaitsuka; Tomoko Soga; Kenneth S Korach; Donald Pfaff; Kazuo Takahama; Sonoko Ogawa
Abolition of sex-dependent effects of prenatal exposure to diethylstilbestrol on emotional behavior in estrogen receptor-alpha knockout mice.
Neuroreport 2006;17(11):1169-73.
2006: M Schmitt; Michael P Walker; R Gregg Richards; Wayne P Bocchinfuso; Tomokazu Fukuda; D Medina; F S Kittrell; Kenneth S Korach; Richard P DiAugustine
Expression of heregulin by mouse mammary tumor cells: role in activation of ErbB receptors.
Molecular carcinogenesis 2006;45(7):490-505.
2006: Yukio Yamamoto; Rick Moore; Holly A Hess; Grace L Guo; Frank J Gonzalez; Kenneth S Korach; Robert R Maronpot; Masahiko Negishi
Estrogen receptor alpha mediates 17alpha-ethynylestradiol causing hepatotoxicity.
The Journal of biological chemistry 2006;281(24):16625-31.
2006: Cedric Le May; Khoi Chu; Min Hu; Christina S Ortega; Evan R Simpson; Kenneth S Korach; Ming-Jer Tsai; Franck Mauvais-Jarvis
Estrogens protect pancreatic beta-cells from apoptosis and prevent insulin-deficient diabetes mellitus in mice.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(24):9232-7.
2006: Derek V Henley; Kenneth S Korach
Endocrine-disrupting chemicals use distinct mechanisms of action to modulate endocrine system function.
Endocrinology 2006;147(6 Suppl):S25-32.
2006: Jian Qiu; Martha A Bosch; Sandra C Tobias; Andrée Krust; Sharon M Graham; Stephanie J Murphy; Kenneth S Korach; Pierre Chambon; Thomas S Scanlan; Oline K Ronnekleiv; Martin J Kelly
A G-protein-coupled estrogen receptor is involved in hypothalamic control of energy homeostasis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(21):5649-55.
2006: Sylvia Curtis Hewitt; Jennifer Collins; Sherry F Grissom; Katherine Hamilton; Kenneth S Korach
Estren behaves as a weak estrogen rather than a nongenomic selective activator in the mouse uterus.
Endocrinology 2006;147(5):2203-14.
2006: Éva Szego; Klaudia Barabás; Júlia Balog; Nóra Szilágyi; Kenneth S Korach; Gábor Juhász; István M Abrahám
Estrogen induces estrogen receptor alpha-dependent cAMP response element-binding protein phosphorylation via mitogen activated protein kinase pathway in basal forebrain cholinergic neurons in vivo.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(15):4104-10.
2006: Masayoshi Nomura; Sandra Andersson; Kenneth S Korach; Jan-�ke GUSTAFSSON; Donald Pfaff; Sonoko Ogawa
Estrogen receptor-beta gene disruption potentiates estrogen-inducible aggression but not sexual behaviour in male mice.
The European journal of neuroscience 2006;23(7):1860-8.
2006: Bonnie J Deroo; Kenneth S Korach
Estrogen receptors and human disease.
The Journal of clinical investigation 2006;116(3):561-70.
2006: Renea A Taylor; P Cowin; John F Couse; Kenneth S Korach; Gail P Risbridger
17beta-estradiol induces apoptosis in the developing rodent prostate independently of ERalpha or ERbeta.
Endocrinology 2006;147(1):191-200.
2005: Hiroaki Aoyama; John F Couse; Sylvia Curtis Hewitt; Joseph K Haseman; Hong He; Xiaolin Zheng; Sonja Majstoravich; Kenneth S Korach; Darlene Dixon
Upregulation of estrogen receptor expression in the uterus of ovariectomized B6C3F1 mice and Ishikawa cells treated with bromoethane.
Toxicology and applied pharmacology 2005;209(3):226-35.
2005: John F Couse; Mariana M Yates; Bonnie J Deroo; Kenneth S Korach
Estrogen receptor-beta is critical to granulosa cell differentiation and the ovulatory response to gonadotropins.
Endocrinology 2005;146(8):3247-62.
2005: Muthuvel Jayachandran; Krzysztof Karnicki; Randall S Miller; Whyte G Owen; Kenneth S Korach; Virginia M Miller
Platelet characteristics change with aging: role of estrogen receptor beta.
The journals of gerontology. Series A, Biological sciences and medical sciences 2005;60(7):815-9.
2005: Judith M A Emmen; John F Couse; Susan A Elmore; Mariana M Yates; Grace E Kissling; Kenneth S Korach
In vitro growth and ovulation of follicles from ovaries of estrogen receptor (ER){alpha} and ER{beta} null mice indicate a role for ER{beta} in follicular maturation.
Endocrinology 2005;146(6):2817-26.
2005: Rajeshwar Tekmal; Ya-Guang Liu; Hareesh B. Nair; Jeremy Jones; Rao P Perla; Dennis B Lubahn; Kenneth S Korach; Nameer Kirma
Estrogen receptor alpha is required for mammary development and the induction of mammary hyperplasia and epigenetic alterations in the aromatase transgenic mice.
The Journal of steroid biochemistry and molecular biology 2005;95(1-5):9-15.
2005: Theo Pelzer; Paula-Anahi Arias Loza; Kai Hu; Barbara Bayer; Charlotte Dienesch; Laura Calvillo; John F Couse; Kenneth S Korach; Ludwig Neyses; Georg Ertl
Increased mortality and aggravation of heart failure in estrogen receptor-beta knockout mice after myocardial infarction.
Circulation 2005;111(12):1492-8.
2005: Sylvia Curtis Hewitt; Bonnie J Deroo; Kenneth S Korach
Signal transduction. A new mediator for an old hormone?
Science (New York, N.Y.) 2005;307(5715):1572-3.
2005: Sylvia Curtis Hewitt; Jennifer Collins; Sherry F Grissom; Bonnie J Deroo; Kenneth S Korach
Global uterine genomics in vivo: microarray evaluation of the estrogen receptor alpha-growth factor cross-talk mechanism.
Molecular endocrinology (Baltimore, Md.) 2005;19(3):657-68.
2005: Angélique Gougelet; Céline Bouclier; Véronique Marsaud; Sébastien Maillard; Stefan O Mueller; Kenneth S Korach; Jack-Michel Renoir
Estrogen receptor alpha and beta subtype expression and transactivation capacity are differentially affected by receptor-, hsp90- and immunophilin-ligands in human breast cancer cells.
The Journal of steroid biochemistry and molecular biology 2005;94(1-3):71-81.
2005: Scott A Gabel; Vickie R Walker; Robert E London; CHARLES STEENBERGEN; Kenneth S Korach; Elizabeth Murphy
Estrogen receptor beta mediates gender differences in ischemia/reperfusion injury.
Journal of molecular and cellular cardiology 2005;38(2):289-97.
2005: Agnieszka A Ardelt; Louise D McCullough; Kenneth S Korach; Michael M Wang; Diane H Munzenmaier; Patricia D Hurn
Estradiol regulates angiopoietin-1 mRNA expression through estrogen receptor-alpha in a rodent experimental stroke model.
Stroke; a journal of cerebral circulation 2005;36(2):337-41.
2005: Maryanne Skavdahl; CHARLES STEENBERGEN; James Clark; Page Myers; Tracy Demianenko; Lan Mao; Howard A Rockman; Kenneth S Korach; Elizabeth Murphy
Estrogen receptor-beta mediates male-female differences in the development of pressure overload hypertrophy.
American journal of physiology. Heart and circulatory physiology 2005;288(2):H469-76.
2005: W Yue; Ji-Ping Wang; Yuebai Li; Wayne P Bocchinfuso; Kenneth S Korach; Prabu Devanesan; Eleanor G Rogan; Ercole L Cavalieri; Richard J Santen
Tamoxifen versus aromatase inhibitors for breast cancer prevention.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(2 Pt 2):925s-30s.
2005: Sylvia Curtis Hewitt; Joshua Chuck Harrell; Kenneth S Korach
Lessons in estrogen biology from knockout and transgenic animals.
Annual review of physiology 2005;67():285-308.
2005: Masayoshi Nomura; Keith T Akama; Stephen E Alves; Kenneth S Korach; Jan-�ke GUSTAFSSON; Donald Pfaff; Sonoko Ogawa
Differential distribution of estrogen receptor (ER)-alpha and ER-beta in the midbrain raphe nuclei and periaqueductal gray in male mouse: Predominant role of ER-beta in midbrain serotonergic systems.
Neuroscience 2005;130(2):445-56.
2004: John F Couse; Kenneth S Korach
Estrogen receptor-alpha mediates the detrimental effects of neonatal diethylstilbestrol (DES) exposure in the murine reproductive tract.
Toxicology 2004;205(1-2):55-63.
2004: Bonnie J Deroo; Sylvia Curtis Hewitt; Shyamal Peddada; Kenneth S Korach
Estradiol regulates the thioredoxin antioxidant system in the mouse uterus.
Endocrinology 2004;145(12):5485-92.
2004: John F Couse; Mariana M Yates; Ryan Sanford; Abraham Nyska; John H Nilson; Kenneth S Korach
Formation of cystic ovarian follicles associated with elevated luteinizing hormone requires estrogen receptor-beta.
Endocrinology 2004;145(10):4693-702.
2004: Stefan O Mueller; John A Katzenellenbogen; Kenneth S Korach
Endogenous estrogen receptor beta is transcriptionally active in primary ovarian cells from estrogen receptor knockout mice.
Steroids 2004;69(10):681-6.
2004: Alecia S Lovegrove; Jianhong Sun; Karen A Gould; Dennis B Lubahn; Kenneth S Korach; Pascale H Lane
Estrogen receptor alpha-mediated events promote sex-specific diabetic glomerular hypertrophy.
American journal of physiology. Renal physiology 2004;287(3):F586-91.
2004: Stefan O Mueller; Stephanie Simon; Kun Chae; Manfred Metzler; Kenneth S Korach
Phytoestrogens and their human metabolites show distinct agonistic and antagonistic properties on estrogen receptor alpha (ERalpha) and ERbeta in human cells.
Toxicological sciences : an official journal of the Society of Toxicology 2004;80(1):14-25.
2004: István M Abrahám; Martin G Todman; Kenneth S Korach; Allan E Herbison
Critical in vivo roles for classical estrogen receptors in rapid estrogen actions on intracellular signaling in mouse brain.
Endocrinology 2004;145(7):3055-61.
2004: Jixiang Ma; Joan Graves; J Alyce Bradbury; Yun Zhao; Deborah L Swope; Lorraine King; Wei Qu; James Clark; Page Myers; Vickie Walker; Jonathan Lindzey; Kenneth S Korach; Darryl C Zeldin
Regulation of mouse renal CYP2J5 expression by sex hormones.
Molecular pharmacology 2004;65(3):730-43.
2004: Hirohisa Harada; Sulaiman Bharwani; Kevin P Pavlick; Kenneth S Korach; Matthew B Grisham
Estrogen receptor-alpha, sexual dimorphism and reduced-size liver ischemia and reperfusion injury in mice.
Pediatric research 2004;55(3):450-6.
2004: Vickie R Walker; Kenneth S Korach
Estrogen receptor knockout mice as a model for endocrine research.
ILAR journal / National Research Council, Institute of Laboratory Animal Resources 2004;45(4):455-61.
2004: Maurizio Longo; Marina Brama; Maria Marino; Silvia Bernardini; Kenneth S Korach; William C Wetsel; Roberto Scandurra; Tullio Faraggiana; Giovanni Spera; Roland Baron; Anna Teti; Silvia Migliaccio
Interaction of estrogen receptor alpha with protein kinase C alpha and c-Src in osteoblasts during differentiation.
Bone 2004;34(1):100-11.
2003: Bin He; Stacey Rhodes-Brower; Michael R Miller; Albert E Munson; Dori R Germolec; Vickie R Walker; Kenneth S Korach; B Jean Meade
Octamethylcyclotetrasiloxane exhibits estrogenic activity in mice via ERalpha.
Toxicology and applied pharmacology 2003;192(3):254-61.
2003: Amber A Dorling; Martin G Todman; Kenneth S Korach; Allan E Herbison
Critical role for estrogen receptor alpha in negative feedback regulation of gonadotropin-releasing hormone mRNA expression in the female mouse.
Neuroendocrinology 2003;78(4):204-9.
2003: Sylvia Curtis Hewitt; Bonnie J Deroo; Katherine Hansen; Jennifer Collins; Sherry F Grissom; Cynthia A Afshari; Kenneth S Korach
Estrogen receptor-dependent genomic responses in the uterus mirror the biphasic physiological response to estrogen.
Molecular endocrinology (Baltimore, Md.) 2003;17(10):2070-83.
2003: Kathleen HELEN Burns; Julio E Agno; Lei Chen; Bisong Haupt; Samuel C Ogbonna; Kenneth S Korach; Martin M Matzuk
Sexually dimorphic roles of steroid hormone receptor signaling in gonadal tumorigenesis.
Molecular endocrinology (Baltimore, Md.) 2003;17(10):2039-52.
2003: Joan Garey; Andrew Goodwillie; Jonathan Frohlich; Maria Morgan; Jan-�ke GUSTAFSSON; Oliver Smithies; Kenneth S Korach; Sonoko Ogawa; Donald Pfaff
Genetic contributions to generalized arousal of brain and behavior.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(19):11019-22.
2003: W Yue; Richard J Santen; Ji-Ping Wang; Yuebai Li; M F Verderame; Wayne P Bocchinfuso; Kenneth S Korach; Prabu Devanesan; Rosa Todorovic; Eleanor G Rogan; Ercole L Cavalieri
Genotoxic metabolites of estradiol in breast: potential mechanism of estradiol induced carcinogenesis.
The Journal of steroid biochemistry and molecular biology 2003;86(3-5):477-86.
2003: Kenneth S Korach; Judith M A Emmen; Vickie R Walker; Sylvia Curtis Hewitt; Mariana Yates; Julie M Hall; Deborah L Swope; Joshua Chuck Harrell; John F Couse
Update on animal models developed for analyses of estrogen receptor biological activity.
The Journal of steroid biochemistry and molecular biology 2003;86(3-5):387-91.
2003: István M Abrahám; Seong-Kyu Han; Martin G Todman; Kenneth S Korach; Allan E Herbison
Estrogen receptor beta mediates rapid estrogen actions on gonadotropin-releasing hormone neurons in vivo.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(13):5771-7.
2003: John F Couse; Mariana M Yates; Vickie R Walker; Kenneth S Korach
Characterization of the hypothalamic-pituitary-gonadal axis in estrogen receptor (ER) Null mice reveals hypergonadism and endocrine sex reversal in females lacking ERalpha but not ERbeta.
Molecular endocrinology (Baltimore, Md.) 2003;17(6):1039-53.
2003: Elena Choleris; Jan-�ke GUSTAFSSON; Kenneth S Korach; Louis J Muglia; Donald Pfaff; Sonoko Ogawa
An estrogen-dependent four-gene micronet regulating social recognition: a study with oxytocin and estrogen receptor-alpha and -beta knockout mice.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(10):6192-7.
2003: Nicholas Kenney; Arthur Bowman; Kenneth S Korach; J Carl Barrett; David S Salomon
Effect of exogenous epidermal-like growth factors on mammary gland development and differentiation in the estrogen receptor-alpha knockout (ERKO) mouse.
Breast cancer research and treatment 2003;79(2):161-73.
2003: Kathleen E McDougall; Mark J Perry; Rachel L Gibson; Shane M Colley; Kenneth S Korach; Jonathan H Tobias
Estrogen receptor-alpha dependency of estrogen's stimulatory action on cancellous bone formation in male mice.
Endocrinology 2003;144(5):1994-9.
2003: Julie M Hall; Kenneth S Korach
Stromal cell-derived factor 1, a novel target of estrogen receptor action, mediates the mitogenic effects of estradiol in ovarian and breast cancer cells.
Molecular endocrinology (Baltimore, Md.) 2003;17(5):792-803.
2003: Stefan O Mueller; Julie M Hall; Deborah L Swope; Lars C Pedersen; Kenneth S Korach
Molecular determinants of the stereoselectivity of agonist activity of estrogen receptors (ER) alpha and beta.
The Journal of biological chemistry 2003;278(14):12255-62.
2003: Judith M A Emmen; Kenneth S Korach
Estrogen receptor knockout mice: phenotypes in the female reproductive tract.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 2003;17(2):169-76.
2003: Angela M Borzychowski; Sirirak Chantakru; Kanwal Minhas; Valdemar A Paffaro; Aureo T Yamada; Hong He; Kenneth S Korach; B Anne Croy
Functional analysis of murine uterine natural killer cells genetically devoid of oestrogen receptors.
Placenta 2003;24(4):403-11.
2003: Sylvia Curtis Hewitt; Kenneth S Korach
Oestrogen receptor knockout mice: roles for oestrogen receptors alpha and beta in reproductive tissues.
Reproduction (Cambridge, England) 2003;125(2):143-9.
2003: Masayoshi Nomura; Kenneth S Korach; Donald Pfaff; Sonoko Ogawa
Estrogen receptor beta (ERbeta) protein levels in neurons depend on estrogen receptor alpha (ERalpha) gene expression and on its ligand in a brain region-specific manner.
Brain research. Molecular brain research 2003;110(1):7-14.
2003: Sonoko Ogawa; Johnny Chan; Jan-�ke GUSTAFSSON; Kenneth S Korach; Donald Pfaff
Estrogen increases locomotor activity in mice through estrogen receptor alpha: specificity for the type of activity.
Endocrinology 2003;144(1):230-9.
2003: Benson T Akingbemi; Renshan Ge; Cheryl S Rosenfeld; Leslie G Newton; Dianne O Hardy; James F Catterall; Dennis B Lubahn; Kenneth S Korach; Matthew P Hardy
Estrogen receptor-alpha gene deficiency enhances androgen biosynthesis in the mouse Leydig cell.
Endocrinology 2003;144(1):84-93.
2002: Masayoshi Nomura; Elizabeth McKenna; Kenneth S Korach; Donald Pfaff; Sonoko Ogawa
Estrogen receptor-beta regulates transcript levels for oxytocin and arginine vasopressin in the hypothalamic paraventricular nucleus of male mice.
Brain research. Molecular brain research 2002;109(1-2):84-94.
2002: Kenneth S Korach
Has it really been five years already?
Endocrinology 2002;143(12):i-ii.
2002: Julie M Hall; Kenneth S Korach
Analysis of the molecular mechanisms of human estrogen receptors alpha and beta reveals differential specificity in target promoter regulation by xenoestrogens.
The Journal of biological chemistry 2002;277(46):44455-61.
2002: Wendy N Jefferson; John F Couse; Elizabeth Padilla-Banks; Kenneth S Korach; Retha R Newbold
Neonatal exposure to genistein induces estrogen receptor (ER)alpha expression and multioocyte follicles in the maturing mouse ovary: evidence for ERbeta-mediated and nonestrogenic actions.
Biology of reproduction 2002;67(4):1285-96.
2002: Sylvia Curtis Hewitt; Eugenia H Goulding; Edward Eddy; Kenneth S Korach
Studies using the estrogen receptor alpha knockout uterus demonstrate that implantation but not decidualization-associated signaling is estrogen dependent.
Biology of reproduction 2002;67(4):1268-77.
2002: Sylvia Curtis Hewitt; Kenneth S Korach
Estrogen receptors: structure, mechanisms and function.
Reviews in endocrine & metabolic disorders 2002;3(3):193-200.
2002: Deborah L Swope; Joshua Chuck Harrell; Dipak Mahato; Kenneth S Korach
Genomic structure and identification of a truncated variant message of the mouse estrogen receptor alpha gene.
Gene 2002;294(1-2):239-47.
2002: Vicki L Davis; Chi-Chao Chan; Timothy J Schoen; John F Couse; Gerald J Chader; Kenneth S Korach
An estrogen receptor repressor induces cataract formation in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(14):9427-32.
2002: Stefan O Mueller; James A Clark; Page H Myers; Kenneth S Korach
Mammary gland development in adult mice requires epithelial and stromal estrogen receptor alpha.
Endocrinology 2002;143(6):2357-65.
2002: Sylvia Curtis Hewitt; Wayne P Bocchinfuso; Jun Zhai; Chuck Harrell; Linwood Koonce; James Clark; Page Myers; Kenneth S Korach
Lack of ductal development in the absence of functional estrogen receptor alpha delays mammary tumor formation induced by transgenic expression of ErbB2/neu.
Cancer research 2002;62(10):2798-805.
2002: Masayoshi Nomura; Larissa Durbak; Johnny Chan; Oliver Smithies; Jan-�ke GUSTAFSSON; Kenneth S Korach; Donald Pfaff; Sonoko Ogawa
Genotype/age interactions on aggressive behavior in gonadally intact estrogen receptor beta knockout (betaERKO) male mice.
Hormones and behavior 2002;41(3):288-96.
2002: Renea A Jarred; Stephen J McPherson; Joseph John Bianco; John F Couse; Kenneth S Korach; Gail P Risbridger
Prostate phenotypes in estrogen-modulated transgenic mice.
Trends in endocrinology and metabolism: TEM 2002;13(4):163-8.
2002: Diane M Klotz; Sylvia Curtis Hewitt; Paolo Ciana; Michele Raviscioni; Jonathan Lindzey; Julie Foley; Stefano Di Giovine; Richard P DiAugustine; Kenneth S Korach
Requirement of estrogen receptor-alpha in insulin-like growth factor-1 (IGF-1)-induced uterine responses and in vivo evidence for IGF-1/estrogen receptor cross-talk.
The Journal of biological chemistry 2002;277(10):8531-7.
2002: Julie M Hall; Donald P McDonnell; Kenneth S Korach
Allosteric regulation of estrogen receptor structure, function, and coactivator recruitment by different estrogen response elements.
Molecular endocrinology (Baltimore, Md.) 2002;16(3):469-86.
2002: C Pendaries; Benoît Darblade; Philippe Rochaix; Andrée Krust; Pierre Chambon; Kenneth S Korach; Francis Bayard; Jean-François Arnal
The AF-1 activation-function of ERalpha may be dispensable to mediate the effect of estradiol on endothelial NO production in mice.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(4):2205-10.
2002: Deborah L Swope; Trisha Castranio; Joshua Chuck Harrell; Yuji Mishina; Kenneth S Korach
AF-2 knock-in mutation of estrogen receptor alpha: Cre-loxP excision of a PGK-neo cassette from the 3' UTR.
Genesis (New York, N.Y. : 2000) 2002;32(2):99-101.
2001: John F Couse; Kenneth S Korach
Contrasting phenotypes in reproductive tissues of female estrogen receptor null mice.
Annals of the New York Academy of Sciences 2001;948():1-8.
2001: Judith M A Emmen; Kenneth S Korach
Developing animal models for analyzing SERM activity.
Annals of the New York Academy of Sciences 2001;949():36-43.
2001: Justine A Levin-Allerhand; Bruce S McEwen; Chris E Lominska; D B Lubahn; Kenneth S Korach; Jonathan D. Smith
Brain region-specific up-regulation of mouse apolipoprotein E by pharmacological estrogen treatments.
Journal of neurochemistry 2001;79(4):796-803.
2001: John F Couse; Darlene Dixon; M Yates; Alicia B Moore; L Ma; R Maas; Kenneth S Korach
Estrogen receptor-alpha knockout mice exhibit resistance to the developmental effects of neonatal diethylstilbestrol exposure on the female reproductive tract.
Developmental biology 2001;238(2):224-38.
2001: Julie M Hall; John F Couse; Kenneth S Korach
The multifaceted mechanisms of estradiol and estrogen receptor signaling.
The Journal of biological chemistry 2001;276(40):36869-72.
2001: Prabu Devanesan; R J Santen; Wayne P Bocchinfuso; Kenneth S Korach; Eleanor G Rogan; Ercole L Cavalieri
Catechol estrogen metabolites and conjugates in mammary tumors and hyperplastic tissue from estrogen receptor-alpha knock-out (ERKO)/Wnt-1 mice: implications for initiation of mammary tumors.
Carcinogenesis 2001;22(9):1573-6.
2001: Stefan O Mueller; Kenneth S Korach
Immortalized testis cell lines from estrogen receptor (ER) alpha knock-out and wild-type mice expressing functional ERalpha or ERbeta.
Journal of andrology 2001;22(4):652-64.
2001: Dipak Mahato; Eugenia H Goulding; Kenneth S Korach; Edward Eddy
Estrogen receptor-alpha is required by the supporting somatic cells for spermatogenesis.
Molecular and cellular endocrinology 2001;178(1-2):57-63.
2001: Jeffrey B Hodgin; John Krege; Robert L Reddick; Kenneth S Korach; Oliver Smithies; Nobuyo Maeda
Estrogen receptor alpha is a major mediator of 17beta-estradiol's atheroprotective effects on lesion size in Apoe-/- mice.
The Journal of clinical investigation 2001;107(3):333-40.
2001: J E Couse; Dipak Mahato; Edward Eddy; Kenneth S Korach
Molecular mechanism of estrogen action in the male: insights from the estrogen receptor null mice.
Reproduction, fertility, and development 2001;13(4):211-9.
2000: Sonoko Ogawa; A E Chester; Sylvia Curtis Hewitt; Vickie R Walker; Jan-�ke GUSTAFSSON; Oliver Smithies; Kenneth S Korach; Donald Pfaff
Abolition of male sexual behaviors in mice lacking estrogen receptors alpha and beta (alpha beta ERKO).
Proceedings of the National Academy of Sciences of the United States of America 2000;97(26):14737-41.
2000: John F Couse; Sylvia Curtis Hewitt; Kenneth S Korach
Receptor null mice reveal contrasting roles for estrogen receptor alpha and beta in reproductive tissues.
The Journal of steroid biochemistry and molecular biology 2000;74(5):287-96.
2000: Stephen E Alves; Bruce S McEwen; S Hayashi; Kenneth S Korach; Donald Pfaff; Sonoko Ogawa
Estrogen-regulated progestin receptors are found in the midbrain raphe but not hippocampus of estrogen receptor alpha (ER alpha) gene-disrupted mice.
The Journal of comparative neurology 2000;427(2):185-95.
2000: Sylvia Curtis Hewitt; Kenneth S Korach
Progesterone action and responses in the alphaERKO mouse.
Steroids 2000;65(10-11):551-7.
2000: Diane M Klotz; Sylvia Curtis Hewitt; Kenneth S Korach; Richard P DiAugustine
Activation of a uterine insulin-like growth factor I signaling pathway by clinical and environmental estrogens: requirement of estrogen receptor-alpha.
Endocrinology 2000;141(9):3430-9.
2000: Wayne P Bocchinfuso; Jonathan Lindzey; Sylvia Curtis Hewitt; James A Clark; Page H Myers; R Cooper; Kenneth S Korach
Induction of mammary gland development in estrogen receptor-alpha knockout mice.
Endocrinology 2000;141(8):2982-94.
2000: Silvia Migliaccio; Retha R Newbold; Anna Teti; W J Jefferson; Svein Toverud; Anna Taranta; BC Bullock; C A Suggs; Giovanni Spera; Kenneth S Korach
Transient estrogen exposure of female mice during early development permanently affects osteoclastogenesis in adulthood.
Bone 2000;27(1):47-52.
2000: Dipak Mahato; Eugenia H Goulding; Kenneth S Korach; Edward Eddy
Spermatogenic cells do not require estrogen receptor-alpha for development or function.
Endocrinology 2000;141(3):1273-6.
2000: Wendy N Jefferson; John F Couse; Elizabeth Padilla Banks; Kenneth S Korach; Retha R Newbold
Expression of estrogen receptor beta is developmentally regulated in reproductive tissues of male and female mice.
Biology of reproduction 2000;62(2):310-7.
2000: Sylvia Curtis Hewitt; John F Couse; Kenneth S Korach
Estrogen receptor transcription and transactivation: Estrogen receptor knockout mice: what their phenotypes reveal about mechanisms of estrogen action.
Breast cancer research : BCR 2000;2(5):345-52.
2000: Kenneth S Korach
Estrogen receptor knock-out mice: molecular and endocrine phenotypes.
Journal of the Society for Gynecologic Investigation 2000;7(1 Suppl):S16-7.
1999: Richard H Karas; Jeffrey B Hodgin; M Kwoun; John Krege; Mark Aronovitz; William C Mackey; Jan-�ke GUSTAFSSON; Kenneth S Korach; Oliver Smithies; Michael Mendelsohn
Estrogen inhibits the vascular injury response in estrogen receptor beta-deficient female mice.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(26):15133-6.
1999: John F Couse; Sylvia Curtis Hewitt; Donna Bunch; M Sar; Vickie R Walker; Barbara J Davis; Kenneth S Korach
Postnatal sex reversal of the ovaries in mice lacking estrogen receptors alpha and beta.
Science (New York, N.Y.) 1999;286(5448):2328-31.
1999: John F Couse; Donna Bunch; Jonathan Lindzey; David W Schomberg; Kenneth S Korach
Prevention of the polycystic ovarian phenotype and characterization of ovulatory capacity in the estrogen receptor-alpha knockout mouse.
Endocrinology 1999;140(12):5855-65.
1999: Sonoko Ogawa; Johnny Chan; A E Chester; Jan-�ke GUSTAFSSON; Kenneth S Korach; Donald Pfaff
Survival of reproductive behaviors in estrogen receptor beta gene-deficient (betaERKO) male and female mice.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(22):12887-92.
1999: Tatsuya Sueyoshi; N Yokomori; Kenneth S Korach; Masahiko Negishi
Developmental action of estrogen receptor-alpha feminizes the growth hormone-Stat5b pathway and expression of Cyp2a4 and Cyp2d9 genes in mouse liver.
Molecular pharmacology 1999;56(3):473-7.
1999: John F Couse; Kenneth S Korach
Estrogen receptor null mice: what have we learned and where will they lead us?
Endocrine reviews 1999;20(3):358-417.
1999: David W Schomberg; John F Couse; A Mukherjee; D B Lubahn; M Sar; K E Mayo; Kenneth S Korach
Targeted disruption of the estrogen receptor-alpha gene in female mice: characterization of ovarian responses and phenotype in the adult.
Endocrinology 1999;140(6):2733-44.
1999: Wayne P Bocchinfuso; WP Hively; John F Couse; Harold Varmus; Kenneth S Korach
A mouse mammary tumor virus-Wnt-1 transgene induces mammary gland hyperplasia and tumorigenesis in mice lacking estrogen receptor-alpha.
Cancer research 1999;59(8):1869-76.
1999: Q Gu; Kenneth S Korach; RL Moss
Rapid action of 17beta-estradiol on kainate-induced currents in hippocampal neurons lacking intracellular estrogen receptors.
Endocrinology 1999;140(2):660-6.
1998: John Krege; Jeffrey B Hodgin; John F Couse; E Enmark; M Warner; J F Mahler; M Sar; Kenneth S Korach; Jan-�ke GUSTAFSSON; Oliver Smithies
Generation and reproductive phenotypes of mice lacking estrogen receptor beta.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(26):15677-82.
1998: Sonoko Ogawa; V Eng; J Taylor; D B Lubahn; Kenneth S Korach; Donald Pfaff
Roles of estrogen receptor-alpha gene expression in reproduction-related behaviors in female mice.
Endocrinology 1998;139(12):5070-81.
1998: Sonoko Ogawa; T F Washburn; J Taylor; D B Lubahn; Kenneth S Korach; Donald Pfaff
Modifications of testosterone-dependent behaviors by estrogen receptor-alpha gene disruption in male mice.
Endocrinology 1998;139(12):5058-69.
1998: Silvia Migliaccio; T F Washburn; S Fillo; H Rivera; Anna Teti; Kenneth S Korach; William C Wetsel
Modulation of estrogen receptor levels in mouse uterus by protein kinase C isoenzymes.
Endocrinology 1998;139(11):4598-606.
1998: Jonathan Lindzey; W C Wetsel; John F Couse; T Stoker; R Cooper; Kenneth S Korach
Effects of castration and chronic steroid treatments on hypothalamic gonadotropin-releasing hormone content and pituitary gonadotropins in male wild-type and estrogen receptor-alpha knockout mice.
Endocrinology 1998;139(10):4092-101.
1998: B R Sadler; S J Cho; K S Ishaq; K Chae; Kenneth S Korach
Three-dimensional quantitative structure-activity relationship study of nonsteroidal estrogen receptor ligands using the comparative molecular field analysis/cross-validated r2-guided region selection approach.
Journal of medicinal chemistry 1998;41(13):2261-7.
1998: Silvia Migliaccio; S Bernardini; William C Wetsel; Kenneth S Korach; Tullio Faraggiana; Anna Teti
Protein kinase C modulates estrogen receptors in differentiated osteoblastic cells in vitro.
Steroids 1998;63(5-6):352-4.
1998: B R Sadler; K Chae; K S Ishaq; Kenneth S Korach
Separation of indenestrol A and B isomers and enantiomers by high-performance liquid chromatography.
Journal of chromatography. A 1998;799(1-2):117-24.
1998: K Chae; Jonathan Lindzey; john alan mclachlan; Kenneth S Korach
Estrogen-dependent gene regulation by an oxidative metabolite of diethylstilbestrol, diethylstilbestrol-4',4"-quinone.
Steroids 1998;63(3):149-57.
1997: John F Couse; Jonathan Lindzey; K Grandien; J A Gustafsson; Kenneth S Korach
Tissue distribution and quantitative analysis of estrogen receptor-alpha (ERalpha) and estrogen receptor-beta (ERbeta) messenger ribonucleic acid in the wild-type and ERalpha-knockout mouse.
Endocrinology 1997;138(11):4613-21.
1997: Wayne P Bocchinfuso; Kenneth S Korach
Mammary gland development and tumorigenesis in estrogen receptor knockout mice.
Journal of mammary gland biology and neoplasia 1997;2(4):323-34.
1997: John F Couse; Vicki L Davis; RB Hanson; Wendy N Jefferson; john alan mclachlan; BC Bullock; Retha R Newbold; Kenneth S Korach
Accelerated onset of uterine tumors in transgenic mice with aberrant expression of the estrogen receptor after neonatal exposure to diethylstilbestrol.
Molecular carcinogenesis 1997;19(4):236-42.
1997: Cesare Carani; K Qin; M Simoni; Marco Faustini-Fustini; S Serpente; J Boyd; Kenneth S Korach; E R Simpson
Effect of testosterone and estradiol in a man with aromatase deficiency.
The New England journal of medicine 1997;337(2):91-5.
1997: O Gandini; H Kohno; S Curtis; Kenneth S Korach
Two transcription activation functions in the amino terminus of the mouse estrogen receptor that are affected by the carboxy terminus.
Steroids 1997;62(7):508-15.
1997: S W Curtis; H Shi; Christina Teng; Kenneth S Korach
Promoter and species specific differential estrogen-mediated gene transcription in the uterus and cultured cells using structurally altered agonists.
Journal of molecular endocrinology 1997;18(3):203-11.
1997: Kathleen M Scully; Anatoli Gleiberman; J Lindzey; D B Lubahn; Kenneth S Korach; Michael G Rosenfeld
Role of estrogen receptor-alpha in the anterior pituitary gland.
Molecular endocrinology (Baltimore, Md.) 1997;11(6):674-81.
1997: Jonathan Lindzey; Kenneth S Korach
Developmental and physiological effects of estrogen receptor gene disruption in mice.
Trends in endocrinology and metabolism: TEM 1997;8(4):137-45.
1997: Mark D Iafrati; Richard H Karas; Mark Aronovitz; S Kim; T R Sullivan; D B Lubahn; Thomas F O'Donnell; Kenneth S Korach; Michael Mendelsohn
Estrogen inhibits the vascular injury response in estrogen receptor alpha-deficient mice.
Nature medicine 1997;3(5):545-8.
1997: Wayne P Bocchinfuso; Kenneth S Korach
Estrogen receptor residues required for stereospecific ligand recognition and activation.
Molecular endocrinology (Baltimore, Md.) 1997;11(5):587-94.
1997: Sonoko Ogawa; D B Lubahn; Kenneth S Korach; Donald Pfaff
Behavioral effects of estrogen receptor gene disruption in male mice.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(4):1476-81.
1997: Emilie F Rissman; A H Early; J A Taylor; Kenneth S Korach; D B Lubahn
Estrogen receptors are essential for female sexual receptivity.
Endocrinology 1997;138(1):507-10.
1996: Sonoko Ogawa; J A Taylor; D B Lubahn; Kenneth S Korach; Donald Pfaff
Reversal of sex roles in genetic female mice by disruption of estrogen receptor gene.
Neuroendocrinology 1996;64(6):467-70.
1996: Edward Eddy; T F Washburn; Donna Bunch; Eugenia H Goulding; B C Gladen; D B Lubahn; Kenneth S Korach
Targeted disruption of the estrogen receptor gene in male mice causes alteration of spermatogenesis and infertility.
Endocrinology 1996;137(11):4796-805.
1996: S W Curtis; T Washburn; C Sewall; Richard P DiAugustine; Jonathan Lindzey; John F Couse; Kenneth S Korach
Physiological coupling of growth factor and steroid receptor signaling pathways: estrogen receptor knockout mice lack estrogen-like response to epidermal growth factor.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(22):12626-30.
1996: H Kohno; Wayne P Bocchinfuso; O Gandini; S W Curtis; Kenneth S Korach
Mutational analysis of the estrogen receptor ligand-binding domain: influence of ligand structure and stereochemistry on transactivation.
Journal of molecular endocrinology 1996;16(3):277-85.
1996: Silvia Migliaccio; Retha R Newbold; BC Bullock; W J Jefferson; F G Sutton; john alan mclachlan; Kenneth S Korach
Alterations of maternal estrogen levels during gestation affect the skeleton of female offspring.
Endocrinology 1996;137(5):2118-25.
1996: D M Ignar-Trowbridge; M Pimentel; M G Parker; john alan mclachlan; Kenneth S Korach
Peptide growth factor cross-talk with the estrogen receptor requires the A/B domain and occurs independently of protein kinase C or estradiol.
Endocrinology 1996;137(5):1735-44.
1996: K M Donaldson; S Y Tong; T Washburn; D B Lubahn; Edward Eddy; John M Hutson; Kenneth S Korach
Morphometric study of the gubernaculum in male estrogen receptor mutant mice.
Journal of andrology 1996;17(2):91-5.
1996: Kenneth S Korach; John F Couse; S W Curtis; T F Washburn; Jonathan Lindzey; Kevin Kimbro; Edward Eddy; Silvia Migliaccio; S M Snedeker; D B Lubahn; David W Schomberg; E P Smith
Estrogen receptor gene disruption: molecular characterization and experimental and clinical phenotypes.
Recent progress in hormone research 1996;51():159-86; discussion 186-8.
1995: John F Couse; S W Curtis; T F Washburn; Edward Eddy; David W Schomberg; Kenneth S Korach
Disruption of the mouse oestrogen receptor gene: resulting phenotypes and experimental findings.
Biochemical Society transactions 1995;23(4):929-35.
1995: John F Couse; S W Curtis; T F Washburn; Jonathan Lindzey; T S Golding; D B Lubahn; Oliver Smithies; Kenneth S Korach
Analysis of transcription and estrogen insensitivity in the female mouse after targeted disruption of the estrogen receptor gene.
Molecular endocrinology (Baltimore, Md.) 1995;9(11):1441-54.
1995: Silvia Migliaccio; Retha R Newbold; john alan mclachlan; Kenneth S Korach
Alterations in estrogen levels during development affects the skeleton: use of an animal model.
Environmental health perspectives 1995;103 Suppl 7():95-7.
1995: Kenneth S Korach; john alan mclachlan
Techniques for detection of estrogenicity.
Environmental health perspectives 1995;103 Suppl 7():5-8.
1995: D M Ignar-Trowbridge; M Pimentel; Christina T Teng; Kenneth S Korach; john alan mclachlan
Cross talk between peptide growth factor and estrogen receptor signaling systems.
Environmental health perspectives 1995;103 Suppl 7():35-8.
1994: Kenneth S Korach
Insights from the study of animals lacking functional estrogen receptor.
Science (New York, N.Y.) 1994;266(5190):1524-7.
1994: John F Couse; V L Davis; W C Tally; Kenneth S Korach
An improved method of genomic DNA extraction for screening transgenic mice.
BioTechniques 1994;17(6):1030-2.
1994: H Kohno; O Gandini; S W Curtis; Kenneth S Korach
Anti-estrogen activity in the yeast transcription system: estrogen receptor mediated agonist response.
Steroids 1994;59(10):572-8.
1994: V L Davis; John F Couse; Eugenia H Goulding; S G Power; Edward Eddy; Kenneth S Korach
Aberrant reproductive phenotypes evident in transgenic mice expressing the wild-type mouse estrogen receptor.
Endocrinology 1994;135(1):379-86.
1994: V L Davis; John F Couse; T K Gray; Kenneth S Korach
Correlation between low levels of estrogen receptors and estrogen responsiveness in two rat osteoblast-like cell lines.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1994;9(7):983-91.
1994: R A Goyer; S Epstein; M Bhattacharyya; Kenneth S Korach; Joel G Pounds
Environmental risk factors for osteoporosis.
Environmental health perspectives 1994;102(4):390-4.
1993: D B Lubahn; Jeffrey S Moyer; T S Golding; John F Couse; Kenneth S Korach; Oliver Smithies
Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(23):11162-6.
1993: Steven D Holladay; B L Blaylock; C E Comment; J J Heindel; W M Fox; Kenneth S Korach; Michael I Luster
Selective prothymocyte targeting by prenatal diethylstilbesterol exposure.
Cellular immunology 1993;152(1):131-42.
1993: Silvia Migliaccio; William C Wetsel; W M Fox; T F Washburn; Kenneth S Korach
Endogenous protein kinase-C activation in osteoblast-like cells modulates responsiveness to estrogen and estrogen receptor levels.
Molecular endocrinology (Baltimore, Md.) 1993;7(9):1133-43.
1993: D M Ignar-Trowbridge; Christina T Teng; K A Ross; M G Parker; Kenneth S Korach; john alan mclachlan
Peptide growth factors elicit estrogen receptor-dependent transcriptional activation of an estrogen-responsive element.
Molecular endocrinology (Baltimore, Md.) 1993;7(8):992-8.
1993: M Ikeda; F Ogata; S W Curtis; D B Lubahn; Frank S French; Elizabeth M Wilson; Kenneth S Korach
Characterization of the DNA-binding domain of the mouse uterine estrogen receptor using site-specific polyclonal antibodies.
The Journal of biological chemistry 1993;268(14):10296-302.
1992: D M Ignar-Trowbridge; K G Nelson; M C Bidwell; S W Curtis; T F Washburn; john alan mclachlan; Kenneth S Korach
Coupling of dual signaling pathways: epidermal growth factor action involves the estrogen receptor.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(10):4658-62.
1992: C D Hébert; S Endo; Kenneth S Korach; J Boyd; J Carl Barrett; john alan mclachlan; Retha R Newbold
Characterization of murine cell lines from diethylstilbestrol-induced uterine endometrial adenocarcinomas.
In vitro cellular & developmental biology : journal of the Tissue Culture Association 1992;28A(5):327-36.
1992: Silvia Migliaccio; V L Davis; M K Gibson; T K Gray; Kenneth S Korach
Estrogens modulate the responsiveness of osteoblast-like cells (ROS 17/2.8) stably transfected with estrogen receptor.
Endocrinology 1992;130(5):2617-24.
1992: Silvia Migliaccio; Retha R Newbold; BC Bullock; john alan mclachlan; Kenneth S Korach
Developmental exposure to estrogens induces persistent changes in skeletal tissue.
Endocrinology 1992;130(3):1756-8.
1991: K Chae; M K Gibson; Kenneth S Korach
Estrogen receptor stereochemistry: ligand binding orientation and influence on biological activity.
Molecular pharmacology 1991;40(5):806-11.
1991: D M Ignar-Trowbridge; A R Hughes; James W Putney; john alan mclachlan; Kenneth S Korach
Diethylstilbestrol stimulates persistent phosphatidylinositol lipid turnover by an estrogen receptor-mediated mechanism in immature mouse uterus.
Endocrinology 1991;129(5):2423-30.
1991: M K Gibson; L A Nemmers; W C Beckman; V L Davis; S W Curtis; Kenneth S Korach
The mechanism of ICI 164,384 antiestrogenicity involves rapid loss of estrogen receptor in uterine tissue.
Endocrinology 1991;129(4):2000-10.
1991: D M Ignar-Trowbridge; K G Nelson; K A Ross; T F Washburn; Kenneth S Korach; john alan mclachlan
Localization of the estrogen receptor in uterine cells by affinity labeling with [3H]tamoxifen aziridine.
The Journal of steroid biochemistry and molecular biology 1991;39(1):131-2.
1991: S W Curtis; Kenneth S Korach
Uterine estrogen receptor-DNA complexes: effects of different ERE sequences, ligands, and receptor forms.
Molecular endocrinology (Baltimore, Md.) 1991;5(7):959-66.
1991: Kenneth S Korach; K Chae; M Gibson; S Curtis
Estrogen receptor stereochemistry: ligand binding and hormonal responsiveness.
Steroids 1991;56(5):263-70.
1991: D A Metzger; S Curtis; Kenneth S Korach
Diethylstilbestrol metabolites and analogs: differential ligand effects on estrogen receptor interactions with nuclear matrix sites.
Endocrinology 1991;128(4):1785-91.
1991: T Washburn; A Hocutt; D L Brautigan; Kenneth S Korach
Uterine estrogen receptor in vivo: phosphorylation of nuclear specific forms on serine residues.
Molecular endocrinology (Baltimore, Md.) 1991;5(2):235-42.
1991: K Chae; S H Johnston; Kenneth S Korach
Multiple estrogen binding sites in the uterus: stereochemistry of receptor and non-receptor binding of diethylstilbestrol and its metabolites.
The Journal of steroid biochemistry and molecular biology 1991;38(1):35-42.
1990: S Yamashita; Retha R Newbold; john alan mclachlan; Kenneth S Korach
The role of the estrogen receptor in uterine epithelial proliferation and cytodifferentiation in neonatal mice.
Endocrinology 1990;127(5):2456-63.
1990: D A Metzger; Kenneth S Korach
Cell-free interaction of the estrogen receptor with mouse uterine nuclear matrix: evidence of saturability, specificity, and resistance to KCl extraction.
Endocrinology 1990;126(4):2190-5.
1990: S W Curtis; Kenneth S Korach
Uterine estrogen receptor interaction with estrogen-responsive DNA sequences in vitro: effects of ligand binding on receptor-DNA complexes.
Molecular endocrinology (Baltimore, Md.) 1990;4(2):276-86.
1989: S Yamashita; Retha R Newbold; john alan mclachlan; Kenneth S Korach
Developmental pattern of estrogen receptor expression in female mouse genital tracts.
Endocrinology 1989;125(6):2888-96.
1989: S Yamashita; Kenneth S Korach
Immunological analysis of the biochemical properties of the uterine estrogen receptor.
Biology of reproduction 1989;40(6):1275-85.
1989: Kenneth S Korach; K Chae; L A Levy; W L Duax; P J Sarver
Diethylstilbestrol metabolites and analogs. Stereochemical probes for the estrogen receptor binding site.
The Journal of biological chemistry 1989;264(10):5642-7.
1988: T Horigome; F Ogata; T S Golding; Kenneth S Korach
Estradiol-stimulated proteolytic cleavage of the estrogen receptor in mouse uterus.
Endocrinology 1988;123(5):2540-8.
1988: Richard P DiAugustine; Peter Petrusz; G I Bell; C F Brown; Kenneth S Korach; john alan mclachlan; Christina T Teng
Influence of estrogens on mouse uterine epidermal growth factor precursor protein and messenger ribonucleic acid.
Endocrinology 1988;122(6):2355-63.
1988: K Chae; L A Levy; Kenneth S Korach
Chromatographic separation and isolation of the enantiomers of diethylstilbestrol metabolites.
Journal of chromatography 1988;439(2):484-7.
1988: V E Quarmby; C Fox-Davies; Retha R Newbold; Kenneth S Korach
Response of the mouse uterus to nafoxidine stimulation: agonism and antagonism.
Biology of reproduction 1988;38(4):945-54.
1988: Kenneth S Korach; T Horigome; Y Tomooka; S Yamashita; Retha R Newbold; john alan mclachlan
Immunodetection of estrogen receptor in epithelial and stromal tissues of neonatal mouse uterus.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(10):3334-7.
1988: T S Golding; Kenneth S Korach
Nuclear estrogen receptor molecular heterogeneity in the mouse uterus.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(1):69-73.
1988: Kenneth S Korach; P Sarver; K Chae; john alan mclachlan; J D McKinney
Estrogen receptor-binding activity of polychlorinated hydroxybiphenyls: conformationally restricted structural probes.
Molecular pharmacology 1988;33(1):120-6.
1987: T Horigome; T S Golding; V E Quarmby; D B Lubahn; K McCarty; Kenneth S Korach
Purification and characterization of mouse uterine estrogen receptor under conditions of varying hormonal status.
Endocrinology 1987;121(6):2099-111.
1987: Kenneth S Korach; L A Levy; P J Sarver
Estrogen receptor stereochemistry: receptor binding and hormonal responses.
Journal of steroid biochemistry 1987;27(1-3):281-90.
1985: Kenneth S Korach; C Fox-Davies; V E Quarmby; M H Swaisgood
Diethylstilbestrol metabolites and analogs. Biochemical probes for differential stimulation of uterine estrogen responses.
The Journal of biological chemistry 1985;260(29):15420-6.
1984: V E Quarmby; C Fox-Davies; Kenneth S Korach
Estrogen action in the mouse uterus: the influence of the neuroendocrine-adrenal axis.
Endocrinology 1984;114(1):108-15.
1982: V E Quarmby; C Fox-Davies; M H Swaisgood; Kenneth S Korach
Estrogen action in the mouse uterus: adrenal modulation of receptor levels.
Endocrinology 1982;110(4):1208-16.