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Eugen Koren

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Eugen Koren; Anne S De Groot; V Jawa; K D Beck; T Boone; D Rivera; L Li; Daniel T Mytych; M Koscec; D Weeraratne; S Swanson; W Martin
Clinical validation of the "in silico" prediction of immunogenicity of a human recombinant therapeutic protein.
James A Lofgren; Iwona Wala; Eugen Koren; Steven J Swanson; Shuqian Jing
Detection of neutralizing anti-therapeutic protein antibodies in serum or plasma samples containing high levels of the therapeutic protein.
Michael S Moxness; Suzanna Tatarewicz; Dohan Weeraratne; Nancy Murakami; Danika Wullner; Daniel T Mytych; Vibha Jawa; Eugen Koren; Steven J Swanson
Immunogenicity testing by electrochemiluminescent detection for antibodies directed against therapeutic human monoclonal antibodies.

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2007: Eugen Koren; Anne S De Groot; V Jawa; K D Beck; T Boone; D Rivera; L Li; Daniel T Mytych; M Koscec; D Weeraratne; S Swanson; W Martin
Clinical validation of the "in silico" prediction of immunogenicity of a human recombinant therapeutic protein.
Clinical immunology (Orlando, Fla.) 2007;124(1):26-32.
2006: James A Lofgren; Iwona Wala; Eugen Koren; Steven J Swanson; Shuqian Jing
Detection of neutralizing anti-therapeutic protein antibodies in serum or plasma samples containing high levels of the therapeutic protein.
Journal of immunological methods 2006;308(1-2):101-8.
2005: Michael S Moxness; Suzanna Tatarewicz; Dohan Weeraratne; Nancy Murakami; Danika Wullner; Daniel T Mytych; Vibha Jawa; Eugen Koren; Steven J Swanson
Immunogenicity testing by electrochemiluminescent detection for antibodies directed against therapeutic human monoclonal antibodies.
Clinical chemistry 2005;51(10):1983-5.
2005: Eugen Koren; Daniel T Mytych; M Koscec; John Ferbas; S Gupta; Michael S Moxness; S Swanson
Strategies for the preclinical and clinical characterization of immunogenicity.
Developments in biologicals 2005;122():195-200.
1999: F A Neethling; M Koscec; R Oriol; D K Cooper; Eugen Koren
A reliable, rapid and inexpensive two-color fluorescence assay to monitor serum cytotoxicity in xenotransplantation.
Journal of immunological methods 1999;222(1-2):31-44.
1997: M Koscec; Eugen Koren; Marianne Wolfson-Reichlin; R D Fugate; Edward P Trieu; Ira N Targoff; Morris Reichlin
Autoantibodies to ribosomal P proteins penetrate into live hepatocytes and cause cellular dysfunction in culture.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(4):2033-41.
1996: S Taniguchi; F A Neethling; Elena Y Korchagina; Nicolai V Bovin; Y Ye; T Kobayashi; M Niekrasz; S Li; Eugen Koren; Rafael Oriol; David K C Cooper
In vivo immunoadsorption of antipig antibodies in baboons using a specific Gal(alpha)1-3Gal column.
Transplantation 1996;62(10):1379-84.
1996: S F Li; F A Neethling; S Taniguchi; J C Yeh; T Kobayashi; Y Ye; Eugen Koren; Richard D Cummings; David K C Cooper
Glycans derived from porcine stomach mucin are effective inhibitors of natural anti-alpha-galactosyl antibodies in vitro and after intravenous infusion in baboons.
Transplantation 1996;62(9):1324-31.
1996: Eugen Koren; F Milotic; F A Neethling; M Koscec; D Fei; T Kobayashi; S Taniguchi; David K C Cooper
Monoclonal antiidiotypic antibodies neutralize cytotoxic effects of anti-alphaGal antibodies.
Transplantation 1996;62(6):837-43.
1996: Eugen Koren; C Corder; G Mueller; H Centurion; G Hallum; J Fesmire; W D McConathy; Petar Alaupovic
Triglyceride enriched lipoprotein particles correlate with the severity of coronary artery disease.
Atherosclerosis 1996;122(1):105-15.
1996: T Kobayashi; F A Neethling; Eugen Koren; S Taniguchi; Y Ye; M Niekrasz; H Takagi; W W Hancock; David K C Cooper
In vitro and in vivo investigation of anticomplement agents FUT-175 and K76COOH, in the prevention of hyperacute rejection following discordant xenotransplantation in a nonhuman primate model.
Transplantation proceedings 1996;28(2):604.
1996: S Taniguchi; F A Neethling; T Kobayashi; Y Ye; M Niekrasz; L Peters; Eugen Koren; Rafael Oriol; David K C Cooper
Ratites (ostrich, emu) as potential heart donors for humans: immunologic considerations.
Transplantation proceedings 1996;28(2):561.
1996: Eugen Koren; F Milotic; F A Neethling; M Kosec; N Kujundzic; T Kobayashi; S Taniguchi; Morris Reichlin; David K C Cooper
Murine monoclonal anti-idiotypic antibodies directed against human anti-alpha Gal antibodies prevent rejection of pig cells in culture: implications for pig-to-human organ xenotransplantation.
Transplantation proceedings 1996;28(2):559.
1995: Eugen Koren; M Koscec; Marianne Wolfson-Reichlin; Fanny M Ebling; Betty P Tsao; Bevra H Hahn; Morris Reichlin
Murine and human antibodies to native DNA that cross-react with the A and D SnRNP polypeptides cause direct injury of cultured kidney cells.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(9):4857-64.
1994: David K C Cooper; Eugen Koren; Rafael Oriol
Oligosaccharides and discordant xenotransplantation.
Immunological reviews 1994;141():31-58.
1994: Y Ye; F A Neethling; M Niekrasz; Eugen Koren; S V Richards; M Martin; Stanley D Kosanke; Rafael Oriol; David K C Cooper
Evidence that intravenously administered alpha-galactosyl carbohydrates reduce baboon serum cytotoxicity to pig kidney cells (PK15) and transplanted pig hearts.
Transplantation 1994;58(3):330-7.
1994: F A Neethling; Eugen Koren; Rafael Oriol; S V Richards; Y Ye; M Kujundzic; David K C Cooper
Immunoadsorption of natural antibodies from human serum by affinity chromatography using specific carbohydrates protects pig cells from cytotoxic destruction.
Transplantation proceedings 1994;26(3):1378.
1994: Eugen Koren; M Kujundzic; M Koscec; F A Neethling; S V Richards; Y Ye; N Zuhdi; David K C Cooper
Cytotoxic effects of human preformed anti-Gal IgG and complement on cultured pig cells.
Transplantation proceedings 1994;26(3):1336-9.
1994: Eugen Koren; F A Neethling; M Koscec; M Kujundzic; S V Richards; Y Ye; Rafael Oriol; David K C Cooper
In vitro model for hyperacute rejection of xenogeneic cells.
Transplantation proceedings 1994;26(3):1166.
1994: David K C Cooper; Eugen Koren; Rafael Oriol
Clinical potential of xenotransplantation.
Transplantation proceedings 1994;26(3):1331-2.
1994: F A Neethling; Eugen Koren; Y Ye; S V Richards; M Kujundzic; Rafael Oriol; David K C Cooper
Protection of pig kidney (PK15) cells from the cytotoxic effect of anti-pig antibodies by alpha-galactosyl oligosaccharides.
Transplantation 1994;57(6):959-63.
1994: M Reichlin; A Martin; E Taylor-Albert; K Tsuzaka; W Zhang; Morris Reichlin; Eugen Koren; Fanny M Ebling; Betty P Tsao; Bevra H Hahn
Lupus autoantibodies to native DNA cross-react with the A and D SnRNP polypeptides.
The Journal of clinical investigation 1994;93(1):443-9.
1993: Eugen Koren; N Dashti; Paul R. Wilson; D M Lee
Methylamine-treated low density lipoproteins elicit different responses in HepG2 cells and macrophages.
Molecular and cellular biochemistry 1993;124(1):67-79.
1993: David K C Cooper; A H Good; Y Ye; Eugen Koren; Rafael Oriol; R M Ippolito; A J Malcolm; F A Neethling; E Romano; N Zuhdi
Specific intravenous carbohydrate therapy: a new approach to the inhibition of antibody-mediated rejection following ABO-incompatible allografting and discordant xenografting.
Transplantation proceedings 1993;25(1 Pt 1):377-8.
1993: David K C Cooper; A H Good; Eugen Koren; Rafael Oriol; A J Malcolm; R M Ippolito; F A Neethling; Y Ye; E Romano; N Zuhdi
Identification of alpha-galactosyl and other carbohydrate epitopes that are bound by human anti-pig antibodies: relevance to discordant xenografting in man.
Transplant immunology 1993;1(3):198-205.
1993: Eugen Koren; F A Neethling; S Richards; M Koscec; Y Ye; N Zuhdi; David K C Cooper
Binding and specificity of major immunoglobulin classes of preformed human anti-pig heart antibodies.
Transplant international : official journal of the European Society for Organ Transplantation 1993;6(6):351-3.
1992: Eugen Koren; V W Armstrong; G Mueller; Paul R. Wilson; Peter Schuff-Werner; J Thiery; T Eisenhauer; Petar Alaupovic; D Seidel
Apolipoprotein A-I and apolipoprotein B containing lipoprotein particles in coronary patients treated with extracorporal low density lipoprotein precipitation (HELP).
Atherosclerosis 1992;95(2-3):157-70.
1992: Eugen Koren; F A Neethling; Y Ye; M Niekrasz; J Baker; M Martin; N Zuhdi; David K C Cooper
Heterogeneity of preformed human antipig xenogeneic antibodies.
Transplantation proceedings 1992;24(2):598-601.
1992: Y Ye; David K C Cooper; M Niekrasz; L L Rolf; Eugen Koren; J Baker; M Martin; J Smith; N Zuhdi
Removal of dog antipig antibody by adsorption with pig red blood cell stroma columns.
Transplantation proceedings 1992;24(2):563-5.
1992: A H Good; David K C Cooper; A J Malcolm; R M Ippolito; Eugen Koren; F A Neethling; Y Ye; N Zuhdi; L R Lamontagne
Identification of carbohydrate structures that bind human antiporcine antibodies: implications for discordant xenografting in humans.
Transplantation proceedings 1992;24(2):559-62.
1992: Eugen Koren; Morris Reichlin; M Koscec; R D Fugate; M Reichlin
Autoantibodies to the ribosomal P proteins react with a plasma membrane-related target on human cells.
The Journal of clinical investigation 1992;89(4):1236-41.
1991: Petar Alaupovic; Carolyn Knight-Gibson; C S Wang; Deborah Downs; Eugen Koren; H B Brewer; R E Gregg
Isolation and characterization of an apoA-II-containing lipoprotein (LP-A-II:B complex) from plasma very low density lipoproteins of patients with Tangier disease and type V hyperlipoproteinemia.
Journal of lipid research 1991;32(1):9-19.
1991: Eugen Koren; M Koscec; Walter J McConathy; R D Fugate
Possible role of macrophages in regression of atherosclerosis.
Progress in lipid research 1991;30(2-3):237-43.
1990: Eugen Koren; J Franzen; R D Fugate; Petar Alaupovic
Analysis of cholesterol ester accumulation in macrophages by the use of digital imaging fluorescence microscopy.
Atherosclerosis 1990;85(2-3):175-84.
1990: Jeffrey M Gimble; M A Dorheim; Q Cheng; Kay L Medina; C S Wang; R Jones; Eugen Koren; C Pietrangeli; Paul W Kincade
Adipogenesis in a murine bone marrow stromal cell line capable of supporting B lineage lymphocyte growth and proliferation: biochemical and molecular characterization.
European journal of immunology 1990;20(2):379-87.
1989: N Dashti; Eugen Koren; Petar Alaupovic
Identification and partial characterization of discrete apolipoprotein A-containing lipoprotein particles secreted by human hepatoma cell line HepG2.
Biochemical and biophysical research communications 1989;163(1):574-80.
1989: Walter J McConathy; Eugen Koren; D L Stiers
Cholesterol crystal uptake and metabolism by P388D1 macrophages.
Atherosclerosis 1989;77(2-3):221-5.
1988: Petar Alaupovic; M Tavella; J M Bard; C S Wang; Per-Ola Attman; Eugen Koren; C Corder; Carolyn Knight-Gibson; Deborah Downs
Lipoprotein particles in hypertriglyceridemic states.
Advances in experimental medicine and biology 1988;243():289-97.
1987: P Puchois; A Kandoussi; P Fievet; J L Fourrier; M Bertrand; Eugen Koren; Jean-Charles Fruchart
Apolipoprotein A-I containing lipoproteins in coronary artery disease.
Atherosclerosis 1987;68(1-2):35-40.
1987: N Dashti; Petar Alaupovic; Carolyn Knight-Gibson; Eugen Koren
Identification and partial characterization of discrete apolipoprotein B containing lipoprotein particles produced by human hepatoma cell line HepG2.
Biochemistry 1987;26(15):4837-46.
1987: Eugen Koren; Petar Alaupovic; D M Lee; N Dashti; H U Kloer; G Wen
Selective isolation of human plasma low-density lipoprotein particles containing apolipoproteins B and E by use of a monoclonal antibody to apolipoprotein B.
Biochemistry 1987;26(10):2734-40.
1987: Eugen Koren; P Puchois; Petar Alaupovic; J Fesmire; A Kandoussi; Jean-Charles Fruchart
Quantification of two different types of apolipoprotein A-I containing lipoprotein particles in plasma by enzyme-linked differential-antibody immunosorbent assay.
Clinical chemistry 1987;33(1):38-43.
1986: Eugen Koren; Carolyn Knight-Gibson; G Wen; L E DeBault; P Alaupovic
Characterization of a monoclonal antibody that binds equally to all apolipoprotein and lipoprotein forms of human plasma apolipoprotein B. II. Isolation of apolipoprotein B-containing lipoproteins from human plasma.
Biochimica et biophysica acta 1986;876(1):101-7.
1986: Eugen Koren; D Solter; D M Lee; Z Reiner; W J McConathy; N Dashti; Petar Alaupovic
Characterization of a monoclonal antibody that binds equally to all apolipoprotein and lipoprotein forms of human plasma apolipoprotein B. I. Specificity and binding studies.
Biochimica et biophysica acta 1986;876(1):91-100.
1986: P Puchois; A Kandoussi; P Duriez; Jean-Charles Fruchart; Walter J McConathy; Eugen Koren
Quantitative determination of human plasma apolipoprotein A-II by a non competitive enzyme-linked immunosorbent assay.
Journal of immunoassay 1986;7(4):285-307.
1985: W J McConathy; Eugen Koren; H Wieland; E M Campos; D M Lee; H U Kloer; Petar Alaupovic
Evaluation of immunoaffinity chromatography for isolating human lipoproteins containing apolipoprotein B.
Journal of chromatography 1985;342(1):46-66.
1985: Eugen Koren; P Puchois; Walter J McConathy; J D Fesmire; Petar Alaupovic
Quantitative determination of human plasma apolipoprotein A-I by a noncompetitive enzyme-linked immunosorbent assay.
Clinica chimica acta; international journal of clinical chemistry 1985;147(2):85-95.
1985: Eugen Koren; W J McConathy; A G Lacko; B Knowles
Detection of lecithin: cholesterol acyltransferase (LCAT) in a human hepatoma cell line.
Cancer biochemistry biophysics 1985;7(4):301-7.
1984: N Dashti; G Wolfbauer; Eugen Koren; B Knowles; Petar Alaupovic
Catabolism of human low density lipoproteins by human hepatoma cell line HepG2.
Biochimica et biophysica acta 1984;794(3):373-84.
1984: P R Blackett; Eugen Koren; R Blackstock; D Downs; C S Wang
Hyperlipidemia in acute lymphoblastic leukemia.
Annals of clinical and laboratory science 1984;14(2):123-9.