Vassilis Koronakis

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Symmons Martyn F; Bokma Evert; Koronakis Eva; Hughes Colin; Koronakis Vassilis
The assembled structure of a complete tripartite bacterial multidrug efflux pump.
Humphreys Daniel; Hume Peter J; Koronakis Vassilis
The Salmonella effector SptP dephosphorylates host AAA+ ATPase VCP to promote development of its intracellular replicative niche.
Hayward Richard D; Hume Peter J; Humphreys Daniel; Phillips Neil; Smith Katherine; Koronakis Vassilis
Clustering transfers the translocated Escherichia coli receptor into lipid rafts to stimulate reversible activation of c-Fyn.

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2009: Symmons Martyn F; Bokma Evert; Koronakis Eva; Hughes Colin; Koronakis Vassilis
The assembled structure of a complete tripartite bacterial multidrug efflux pump.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(17):7173-8.
2009: Humphreys Daniel; Hume Peter J; Koronakis Vassilis
The Salmonella effector SptP dephosphorylates host AAA+ ATPase VCP to promote development of its intracellular replicative niche.
Cell host & microbe 2009;5(3):225-33.
2009: Hayward Richard D; Hume Peter J; Humphreys Daniel; Phillips Neil; Smith Katherine; Koronakis Vassilis
Clustering transfers the translocated Escherichia coli receptor into lipid rafts to stimulate reversible activation of c-Fyn.
Cellular microbiology 2009;11(3):433-41.
2009: McGhie Emma J; Brawn Lyndsey C; Hume Peter J; Humphreys Daniel; Koronakis Vassilis
Salmonella takes control: effector-driven manipulation of the host.
Current opinion in microbiology 2009;12(1):117-24.
2008: Hume Peter J; Koronakis Vassilis
Mimicry is the sincerest form of flattery?
Cell host & microbe 2008;4(5):411-2.
2008: Campellone Kenneth G; Cheng Hui-Chun; Robbins Douglas; Siripala Anosha D; McGhie Emma J; Hayward Richard D; Welch Matthew D; Rosen Michael K; Koronakis Vassilis; Leong John M
Repetitive N-WASP-binding elements of the enterohemorrhagic Escherichia coli effector EspF(U) synergistically activate actin assembly.
PLoS pathogens 2008;4(10):e1000191.
2008: Cain Robert J; Hayward Richard D; Koronakis Vassilis
Deciphering interplay between Salmonella invasion effectors.
PLoS pathogens 2008;4(4):e1000037.
2007: Brawn Lyndsey C; Hayward Richard D; Koronakis Vassilis
Salmonella SPI1 effector SipA persists after entry and cooperates with a SPI2 effector to regulate phagosome maturation and intracellular replication.
Cell host & microbe 2007;1(1):63-75.
2007: Lobedanz Sune; Bokma Evert; Symmons Martyn F; Koronakis Eva; Hughes Colin; Koronakis Vassilis
A periplasmic coiled-coil interface underlying TolC recruitment and the assembly of bacterial drug efflux pumps.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(11):4612-7.
2006: Bokma Evert; Koronakis Eva; Lobedanz Sune; Hughes Colin; Koronakis Vassilis
Directed evolution of a bacterial efflux pump: adaptation of the E. coli TolC exit duct to the Pseudomonas MexAB translocase.
FEBS letters 2006;580(22):5339-43.
2006: Vaccaro Loredana; Koronakis Vassilis; Sansom Mark S P
Flexibility in a drug transport accessory protein: molecular dynamics simulations of MexA.
Biophysical journal 2006;91(2):558-64.
2006: Hayward Richard D; Leong John M; Koronakis Vassilis; Campellone Kenneth G
Exploiting pathogenic Escherichia coli to model transmembrane receptor signalling.
Nature reviews. Microbiology 2006;4(5):358-70.
2006: Hayward Richard D; Koronakis Vassilis
Pathogens reWritE Rho's rules.
Cell 2006;124(1):15-7.
2005: Hayward Richard D; Cain Robert J; McGhie Emma J; Phillips Neil; Garner Matthew J; Koronakis Vassilis
Cholesterol binding by the bacterial type III translocon is essential for virulence effector delivery into mammalian cells.
Molecular microbiology 2005;56(3):590-603.
2004: Eswaran Jeyanthy; Koronakis Eva; Higgins Matthew K; Hughes Colin; Koronakis Vassilis
Three's company: component structures bring a closer view of tripartite drug efflux pumps.
Current opinion in structural biology 2004;14(6):741-7.
2004: Cain Robert J; Hayward Richard D; Koronakis Vassilis
The target cell plasma membrane is a critical interface for Salmonella cell entry effector-host interplay.
Molecular microbiology 2004;54(4):887-904.
2004: Higgins Matthew K; Eswaran Jeyanthy; Edwards Patricia; Schertler Gebhard F X; Hughes Colin; Koronakis Vassilis
Structure of the ligand-blocked periplasmic entrance of the bacterial multidrug efflux protein TolC.
Journal of molecular biology 2004;342(3):697-702.
2004: Touzé Thierry; Eswaran Jeyanthy; Bokma Evert; Koronakis Eva; Hughes Colin; Koronakis Vassilis
Interactions underlying assembly of the Escherichia coli AcrAB-TolC multidrug efflux system.
Molecular microbiology 2004;53(2):697-706.
2004: Higgins Matthew K; Bokma Evert; Koronakis Eva; Hughes Colin; Koronakis Vassilis
Structure of the periplasmic component of a bacterial drug efflux pump.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(27):9994-9.
2004: Phillips Neil; Hayward Richard D; Koronakis Vassilis
Phosphorylation of the enteropathogenic E. coli receptor by the Src-family kinase c-Fyn triggers actin pedestal formation.
Nature cell biology 2004;6(7):618-25.
2004: McGhie Emma J; Hayward Richard D; Koronakis Vassilis
Control of actin turnover by a salmonella invasion protein.
Molecular cell 2004;13(4):497-510.
2004: Touzé Thierry; Hayward Richard D; Eswaran Jeyanthy; Leong John M; Koronakis Vassilis
Self-association of EPEC intimin mediated by the beta-barrel-containing anchor domain: a role in clustering of the Tir receptor.
Molecular microbiology 2004;51(1):73-87.
2004: Koronakis Vassilis; Eswaran Jeyanthy; Hughes Colin
Structure and function of TolC: the bacterial exit duct for proteins and drugs.
Annual review of biochemistry 2004;73():467-89.
2003: Koronakis Vassilis
TolC--the bacterial exit duct for proteins and drugs.
FEBS letters 2003;555(1):66-71.
2003: Hume Peter J; McGhie Emma J; Hayward Richard D; Koronakis Vassilis
The purified Shigella IpaB and Salmonella SipB translocators share biochemical properties and membrane topology.
Molecular microbiology 2003;49(2):425-39.
2003: Eswaran Jeyanthy; Hughes Colin; Koronakis Vassilis
Locking TolC entrance helices to prevent protein translocation by the bacterial type I export apparatus.
Journal of molecular biology 2003;327(2):309-15.
2002: Hayward Richard D; Hume Peter J; McGhie Emma J; Koronakis Vassilis
A Salmonella SipB-derived polypeptide blocks the 'trigger' mechanism of bacterial entry into eukaryotic cells.
Molecular microbiology 2002;45(6):1715-27.
2002: Musson Julie A; Hayward Richard D; Delvig Alexei A; Hormaeche Carlos E; Koronakis Vassilis; Robinson John H
Processing of viable Salmonella typhimurium for presentation of a CD4 T cell epitope from the Salmonella invasion protein C (SipC).
European journal of immunology 2002;32(9):2664-71.
2002: Andersen Christian; Koronakis Eva; Bokma Evert; Eswaran Jeyanthy; Humphreys Daniel; Hughes Colin; Koronakis Vassilis
Transition to the open state of the TolC periplasmic tunnel entrance.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(17):11103-8.
2002: McGhie Emma J; Hume Peter J; Hayward Richard D; Torres Jaume; Koronakis Vassilis
Topology of the Salmonella invasion protein SipB in a model bilayer.
Molecular microbiology 2002;44(5):1309-21.
2002: Andersen Christian; Koronakis Eva; Hughes Colin; Koronakis Vassilis
An aspartate ring at the TolC tunnel entrance determines ion selectivity and presents a target for blocking by large cations.
Molecular microbiology 2002;44(5):1131-9.
2002: Garner Matthew J; Hayward Richard D; Koronakis Vassilis
The Salmonella pathogenicity island 1 secretion system directs cellular cholesterol redistribution during mammalian cell entry and intracellular trafficking.
Cellular microbiology 2002;4(3):153-65.
2002: Andersen C; Hughes C; Koronakis V
Electrophysiological behavior of the TolC channel-tunnel in planar lipid bilayers.
The Journal of membrane biology 2002;185(1):83-92.
2002: Hayward Richard D; Koronakis Vassilis
Direct modulation of the host cell cytoskeleton by Salmonella actin-binding proteins.
Trends in cell biology 2002;12(1):15-20.
2001: Balakrishnan L; Hughes C; Koronakis V
Substrate-triggered recruitment of the TolC channel-tunnel during type I export of hemolysin by Escherichia coli.
Journal of molecular biology 2001;313(3):501-10.
2001: Hyland C; Vuillard L; Hughes C; Koronakis V
Membrane interaction of Escherichia coli hemolysin: flotation and insertion-dependent labeling by phospholipid vesicles.
Journal of bacteriology 2001;183(18):5364-70.
2001: Koronakis V; Andersen C; Hughes C
Channel-tunnels.
Current opinion in structural biology 2001;11(4):403-7.
2001: Andersen C; Hughes C; Koronakis V
Protein export and drug efflux through bacterial channel-tunnels.
Current opinion in cell biology 2001;13(4):412-6.
2001: McGhie E J; Hayward R D; Koronakis V
Cooperation between actin-binding proteins of invasive Salmonella: SipA potentiates SipC nucleation and bundling of actin.
The EMBO journal 2001;20(9):2131-9.
2000: Andersen C; Hughes C; Koronakis V
Chunnel vision. Export and efflux through bacterial channel-tunnels.
EMBO reports 2000;1(4):313-8.
2000: Hayward R D; McGhie E J; Koronakis V
Membrane fusion activity of purified SipB, a Salmonella surface protein essential for mammalian cell invasion.
Molecular microbiology 2000;37(4):727-39.
2000: Koronakis V; Sharff A; Koronakis E; Luisi B; Hughes C
Crystal structure of the bacterial membrane protein TolC central to multidrug efflux and protein export.
Nature 2000;405(6789):914-9.
2000: Sharff A J; Koronakis E; Luisi B; Koronakis V
Oxidation of selenomethionine: some MADness in the method!
Acta crystallographica. Section D, Biological crystallography 2000;56(Pt 6):785-8.
2000: Bailey M J; Hughes C; Koronakis V
In vitro recruitment of the RfaH regulatory protein into a specialised transcription complex, directed by the nucleic acid ops element.
Molecular & general genetics : MGG 2000;262(6):1052-9.
1999: Stanley P; Hyland C; Koronakis V; Hughes C
An ordered reaction mechanism for bacterial toxin acylation by the specialized acyltransferase HlyC: formation of a ternary complex with acylACP and protoxin substrates.
Molecular microbiology 1999;34(5):887-901.
1999: Hayward R D; Koronakis V
Direct nucleation and bundling of actin by the SipC protein of invasive Salmonella.
The EMBO journal 1999;18(18):4926-34.
1999: Crago A M; Koronakis V
Binding of extracellular matrix laminin to Escherichia coli expressing the Salmonella outer membrane proteins Rck and PagC.
FEMS microbiology letters 1999;176(2):495-501.
1998: Thanabalu T; Koronakis E; Hughes C; Koronakis V
Substrate-induced assembly of a contiguous channel for protein export from E.coli: reversible bridging of an inner-membrane translocase to an outer membrane exit pore.
The EMBO journal 1998;17(22):6487-96.
1998: Crago A M; Koronakis V
Salmonella InvG forms a ring-like multimer that requires the InvH lipoprotein for outer membrane localization.
Molecular microbiology 1998;30(1):47-56.
1998: Stanley P; Koronakis V; Hughes C
Acylation of Escherichia coli hemolysin: a unique protein lipidation mechanism underlying toxin function.
Microbiology and molecular biology reviews : MMBR 1998;62(2):309-33.
1998: Wong K R; Hughes C; Koronakis V
A gene, yaeQ, that suppresses reduced operon expression caused by mutations in the transcription elongation gene rfaH in Escherichia coli and Salmonella typhimurium.
Molecular & general genetics : MGG 1998;257(6):693-6.
1997: Bailey M J; Hughes C; Koronakis V
RfaH and the ops element, components of a novel system controlling bacterial transcription elongation.
Molecular microbiology 1997;26(5):845-51.
1997: Koronakis V; Li J; Koronakis E; Stauffer K
Structure of TolC, the outer membrane component of the bacterial type I efflux system, derived from two-dimensional crystals.
Molecular microbiology 1997;23(3):617-26.
1996: Bailey M J; Hughes C; Koronakis V
Increased distal gene transcription by the elongation factor RfaH, a specialized homologue of NusG.
Molecular microbiology 1996;22(4):729-37.
1996: Koronakis V; Hughes C
Synthesis, maturation and export of the E. coli hemolysin.
Medical microbiology and immunology 1996;185(2):65-71.
1996: Stanley P; Koronakis V; Hardie K; Hughes C
Independent interaction of the acyltransferase HlyC with two maturation domains of the Escherichia coli toxin HlyA.
Molecular microbiology 1996;20(4):813-22.
1996: Nieto J M; Bailey M J; Hughes C; Koronakis V
Suppression of transcription polarity in the Escherichia coli haemolysin operon by a short upstream element shared by polysaccharide and DNA transfer determinants.
Molecular microbiology 1996;19(4):705-13.
1995: Koronakis E; Hughes C; Milisav I; Koronakis V
Protein exporter function and in vitro ATPase activity are correlated in ABC-domain mutants of HlyB.
Molecular microbiology 1995;16(1):87-96.
1994: Stanley P; Packman L C; Koronakis V; Hughes C
Fatty acylation of two internal lysine residues required for the toxic activity of Escherichia coli hemolysin.
Science (New York, N.Y.) 1994;266(5193):1992-6.
1993: Milisav-Ribaric I; Hughes C; Koronakis E; Koronakis V
ATPase activity and ATP/ADP-induced conformational change in the bacterial toxin exporter hemolysin B.
Biochemical Society transactions 1993;21(4):347S.
1993: Koronakis V; Hughes C; Koronakis E
ATPase activity and ATP/ADP-induced conformational change in the soluble domain of the bacterial protein translocator HlyB.
Molecular microbiology 1993;8(6):1163-75.
1993: Koronakis V; Hughes C
Bacterial signal peptide-independent protein export: HlyB-directed secretion of hemolysin.
Seminars in cell biology 1993;4(1):7-15.
1992: Koronakis V; Stanley P; Koronakis E; Hughes C
The HlyB/HlyD-dependent secretion of toxins by gram-negative bacteria.
FEMS microbiology immunology 1992;5(1-3):45-53.
1992: Hughes C; Issartel J P; Hardie K; Stanley P; Koronakis E; Koronakis V
Activation of Escherichia coli prohemolysin to the membrane-targetted toxin by HlyC-directed ACP-dependent fatty acylation.
FEMS microbiology immunology 1992;5(1-3):37-43.
1992: Hughes C; Stanley P; Koronakis V
E. coli hemolysin interactions with prokaryotic and eukaryotic cell membranes.
BioEssays : news and reviews in molecular, cellular and developmental biology 1992;14(8):519-25.
1992: Bailey M J; Koronakis V; Schmoll T; Hughes C
Escherichia coli HlyT protein, a transcriptional activator of haemolysin synthesis and secretion, is encoded by the rfaH (sfrB) locus required for expression of sex factor and lipopolysaccharide genes.
Molecular microbiology 1992;6(8):1003-12.
1991: Koronakis V; Hughes C; Koronakis E
Energetically distinct early and late stages of HlyB/HlyD-dependent secretion across both Escherichia coli membranes.
The EMBO journal 1991;10(11):3263-72.
1991: Stanley P; Koronakis V; Hughes C
Mutational analysis supports a role for multiple structural features in the C-terminal secretion signal of Escherichia coli haemolysin.
Molecular microbiology 1991;5(10):2391-403.
1991: Hardie K R; Issartel J P; Koronakis E; Hughes C; Koronakis V
In vitro activation of Escherichia coli prohaemolysin to the mature membrane-targeted toxin requires HlyC and a low molecular-weight cytosolic polypeptide.
Molecular microbiology 1991;5(7):1669-79.
1991: Issartel J P; Koronakis V; Hughes C
Activation of Escherichia coli prohaemolysin to the mature toxin by acyl carrier protein-dependent fatty acylation.
Nature 1991;351(6329):759-61.
1990: Cross M A; Koronakis V; Stanley P L; Hughes C
HlyB-dependent secretion of hemolysin by uropathogenic Escherichia coli requires conserved sequences flanking the chromosomal hly determinant.
Journal of bacteriology 1990;172(3):1217-24.
1989: Koronakis V; Cross M; Hughes C
Transcription antitermination in an Escherichia coli haemolysin operon is directed progressively by cis-acting DNA sequences upstream of the promoter region.
Molecular microbiology 1989;3(10):1397-404.
1989: Koronakis V; Koronakis E; Hughes C
Isolation and analysis of the C-terminal signal directing export of Escherichia coli hemolysin protein across both bacterial membranes.
The EMBO journal 1989;8(2):595-605.
1988: Koronakis V; Koronakis E; Hughes C
Comparison of the haemolysin secretion protein HlyB from Proteus vulgaris and Escherichia coli; site-directed mutagenesis causing impairment of export function.
Molecular & general genetics : MGG 1988;213(2-3):551-5.
1988: Koronakis V E; Ross A M; Le Page R W; Hughes C
Nuclear factors binding to the mini-exon repeat of Trypanosoma brucei.
Molecular and biochemical parasitology 1988;30(1):89-96.
1988: Koronakis V; Hughes C
Identification of the promoters directing in vivo expression of hemolysin genes in Proteus vulgaris and Escherichia coli.
Molecular & general genetics : MGG 1988;213(1):99-104.
1988: Koronakis V; Cross M; Hughes C
Expression of the E.coli hemolysin secretion gene hlyB involves transcript anti-termination within the hly operon.
Nucleic acids research 1988;16(11):4789-800.
1987: Koronakis V; Cross M; Senior B; Koronakis E; Hughes C
The secreted hemolysins of Proteus mirabilis, Proteus vulgaris, and Morganella morganii are genetically related to each other and to the alpha-hemolysin of Escherichia coli.
Journal of bacteriology 1987;169(4):1509-15.

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Vassilis Koronakis

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