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Stanley Korsmeyer

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David Y Chen; Emily Cheng; Yiyu Dong; Richard Gussio; Ann Hermone; Stanley J Korsmeyer; Yishan Lee; Han Liu; Kyoung J Oh; David Piwnica-Worms; Adam C Searleman; Robert H Shoemaker; Shugaku Takeda; Ho-Chou Tu; Brian A Van Tine; Todd D Westergard; James Hsieh
A pharmacologic inhibitor of the protease Taspase1 effectively inhibits breast and brain tumor growth.
Sebastián Zamorano; Emily H Cheng; Felipe A Court; Stanley J Korsmeyer; Sergio Lavandero; Fernanda Lisbona; Valentina Parra; Diego Rojas-Rivera; Rosario Villegas; Claudio A Hetz
A BAX/BAK and cyclophilin D-independent intrinsic apoptosis pathway.
David G Kirsch; Philip M Santiago; Emmanuelle di Tomaso; Julie M Sullivan; Wu-Shiun Hou; Talya Dayton; Laura B Jeffords; Pooja Sodha; Kim L Mercer; Rhianna Cohen; Osamu Takeuchi; Stanley J Korsmeyer; Roderick T Bronson; Carla F. Kim; Kevin M Haigis; Rakesh K Jain; Tyler Jacks
p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis.

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2012: David Y Chen; Emily Cheng; Yiyu Dong; Richard Gussio; Ann Hermone; Stanley J Korsmeyer; Yishan Lee; Han Liu; Kyoung J Oh; David Piwnica-Worms; Adam C Searleman; Robert H Shoemaker; Shugaku Takeda; Ho-Chou Tu; Brian A Van Tine; Todd D Westergard; James Hsieh
A pharmacologic inhibitor of the protease Taspase1 effectively inhibits breast and brain tumor growth.
Cancer research 2012;72(3):736-46.
2012: Sebastián Zamorano; Emily H Cheng; Felipe A Court; Stanley J Korsmeyer; Sergio Lavandero; Fernanda Lisbona; Valentina Parra; Diego Rojas-Rivera; Rosario Villegas; Claudio A Hetz
A BAX/BAK and cyclophilin D-independent intrinsic apoptosis pathway.
PloS one 2012;7(6):e37782.
2010: David G Kirsch; Philip M Santiago; Emmanuelle di Tomaso; Julie M Sullivan; Wu-Shiun Hou; Talya Dayton; Laura B Jeffords; Pooja Sodha; Kim L Mercer; Rhianna Cohen; Osamu Takeuchi; Stanley J Korsmeyer; Roderick T Bronson; Carla F. Kim; Kevin M Haigis; Rakesh K Jain; Tyler Jacks
p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis.
Science (New York, N.Y.) 2010;327(5965):593-6.
2009: Decheng Ren; Hyungjin Kim; Ho-Chou Tu; Todd D Westergard; Jill K Fisher; Jeff A Rubens; Stanley J Korsmeyer; James Hsieh; Emily Cheng
The VDAC2-BAK rheostat controls thymocyte survival.
Science signaling 2009;2(85):ra48.
2008: Nika N Danial; Loren D Walensky; Chen-Yu zhang; Cheol Soo Choi; Jill K Fisher; Anthony J A Molina; Sandeep Robert Datta; Kenneth L Pitter; Gregory H Bird; Jakob D Wikstrom; Jude T Deeney; Kirsten Robertson; Joel Morash; Ameya Kulkarni; Susanne Neschen; Sheene Kim; Michael E Greenberg; Barbara E Corkey; orian shirihai; Gerald I Shulman; Bradford B Lowell; Stanley J Korsmeyer
Dual role of proapoptotic BAD in insulin secretion and beta cell survival.
Nature medicine 2008;14(2):144-53.
2008: Robert T Woodland; Casey J Fox; Madelyn R Schmidt; Peter S Hammerman; Joseph T Opferman; Stanley J Korsmeyer; David M Hilbert; Craig Thompson
Multiple signaling pathways promote B lymphocyte stimulator dependent B-cell growth and survival.
Blood 2008;111(2):750-60.
2007: David G Kirsch; Daniela M Dinulescu; John B Miller; Jan Grimm; Philip M Santiago; Nathan P Young; G Petur Nielsen; Bradley J Quade; Christopher J Chaber; Christian P Schultz; Osamu Takeuchi; Roderick T Bronson; Denise Crowley; Stanley J Korsmeyer; Sam S Yoon; Francis J Hornicek; Ralph Weissleder; Tyler Jacks
A spatially and temporally restricted mouse model of soft tissue sarcoma.
Nature medicine 2007;13(8):992-7.
2007: Antonio Ruiz-Vela; Stanley J Korsmeyer
Proapoptotic histone H1.2 induces CASP-3 and -7 activation by forming a protein complex with CYT c, APAF-1 and CASP-9.
FEBS letters 2007;581(18):3422-8.
2007: Se Young Kim; Jonathan M Levenson; Stanley J Korsmeyer; J David Sweatt; Armin Schumacher
Developmental regulation of Eed complex composition governs a switch in global histone modification in brain.
The Journal of biological chemistry 2007;282(13):9962-72.
2007: Federico Bernal; Andrew F Tyler; Stanley J Korsmeyer; Loren D Walensky; Gregory L Verdine
Reactivation of the p53 tumor suppressor pathway by a stapled p53 peptide.
Journal of the American Chemical Society 2007;129(9):2456-7.
2006: Kyoung Joon Oh; Scott Barbuto; Kenneth Pitter; Joel Morash; Loren D Walensky; Stanley J Korsmeyer
A membrane-targeted BID BCL-2 homology 3 peptide is sufficient for high potency activation of BAX in vitro.
The Journal of biological chemistry 2006;281(48):36999-7008.
2006: Loren D Walensky; Kenneth Pitter; Joel Morash; Kyoung Joon Oh; Scott Barbuto; Jill Fisher; Eric Smith; Gregory L Verdine; Stanley J Korsmeyer
A stapled BID BH3 helix directly binds and activates BAX.
Molecular cell 2006;24(2):199-210.
2006: Shugaku Takeda; David Y Chen; Todd D Westergard; Jill K Fisher; Jeffrey A Rubens; Satoru Sasagawa; Jason T Kan; Stanley J Korsmeyer; Emily Cheng; James Hsieh
Proteolysis of MLL family proteins is essential for taspase1-orchestrated cell cycle progression.
Genes & development 2006;20(17):2397-409.
2006: Stephen S Lin; Michael C Bassik; Heikyung Suh; Mari Nishino; Jason Arroyo; William C Hahn; Stanley J Korsmeyer; Thomas M Roberts
PP2A regulates BCL-2 phosphorylation and proteasome-mediated degradation at the endoplasmic reticulum.
The Journal of biological chemistry 2006;281(32):23003-12.
2006: Michael Certo; Victoria D. Moore; Mari Nishino; Guo Wei; Stanley J Korsmeyer; Scott A Armstrong; Anthony Letai
Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members.
Cancer cell 2006;9(5):351-65.
2006: Daniela Bermpohl; Zerong You; Stanley J Korsmeyer; Michael A Moskowitz; Michael J Whalen
Traumatic brain injury in mice deficient in Bid: effects on histopathology and functional outcome.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2006;26(5):625-33.
2006: Claudio Hetz; Paula Bernasconi; Jill Fisher; Ann-Hwee Lee; Michael C Bassik; Bruno Antonsson; Gabriel S Brandt; Neal N Iwakoshi; Anna Schinzel; Laurie H Glimcher; Stanley J Korsmeyer
Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha.
Science (New York, N.Y.) 2006;312(5773):572-6.
2006: Huiqing Zhou; Salvatore Spicuglia; James Hsieh; Dimitra J Mitsiou; Torill Høiby; Gert Jan C Veenstra; Stanley J Korsmeyer; Hendrik G Stunnenberg
Uncleaved TFIIA is a substrate for taspase 1 and active in transcription.
Molecular and cellular biology 2006;26(7):2728-35.
2005: Claudio Hetz; Pierre-Alain Vitte; Agnes Bombrun; Tatiana K Rostovtseva; Sylvie Montessuit; Agnes Hiver; Matthias K Schwarz; Dennis J Church; Stanley J Korsmeyer; Jean-Claude Martinou; Bruno Antonsson
Bax channel inhibitors prevent mitochondrion-mediated apoptosis and protect neurons in a model of global brain ischemia.
The Journal of biological chemistry 2005;280(52):42960-70.
2005: Yoshihiro Nakatani; Hiroaki Konishi; Alex Vassilev; Hisanori Kurooka; Keiichiro Ishiguro; Jun-ichi Sawada; Tsuyoshi Ikura; Stanley J Korsmeyer; Jun Qin; Anna M Herlitz
p600, a unique protein required for membrane morphogenesis and cell survival.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(42):15093-8.
2005: Sandra S Zinkel; Kristen E Hurov; Christy Ong; Farvardean M Abtahi; Atan Gross; Stanley J Korsmeyer
A role for proapoptotic BID in the DNA-damage response.
Cell 2005;122(4):579-91.
2005: Anna C Schinzel; Osamu Takeuchi; Zhihong Huang; Jill K Fisher; Zhipeng Zhou; Jeffery Rubens; Claudio Hetz; Nika N Danial; Michael A Moskowitz; Stanley J Korsmeyer
Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(34):12005-10.
2005: Osamu Takeuchi; Jill Fisher; Heikyung Suh; Hisashi Harada; Barbara A Malynn; Stanley J Korsmeyer
Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(32):11272-7.
2005: Laurent M Dejean; Sonia Martinez-Caballero; Liang Guo; Cynthia Hughes; Oscar Teijido; Thomas Ducret; François Ichas; Stanley J Korsmeyer; Bruno Antonsson; Elizabeth A Jonas; Kathleen W Kinnally
Oligomeric Bax is a component of the putative cytochrome c release channel MAC, mitochondrial apoptosis-induced channel.
Molecular biology of the cell 2005;16(5):2424-32.
2005: Antonio Ruiz-Vela; Joseph T Opferman; Emily Cheng; Stanley J Korsmeyer
Proapoptotic BAX and BAK control multiple initiator caspases.
EMBO reports 2005;6(4):379-85.
2005: Malay Mandal; Christine Borowski; Teresa Palomero; Adolfo Ferrando; Philipp Oberdoerffer; Fanyong Meng; Antonio Ruiz-Vela; Maria Ciofani; Juan Carlos Zuniga-Pflucker; Isabella Screpanti; A Thomas Look; Stanley J Korsmeyer; Klaus Rajewsky; Harald von Boehmer; Ioannis Aifantis
The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival.
The Journal of experimental medicine 2005;201(4):603-14.
2005: Joseph T Opferman; Hiromi Iwasaki; Christy C Ong; Heikyung Suh; Shin-ichi Mizuno; Koichi Akashi; Stanley J Korsmeyer
Obligate role of anti-apoptotic MCL-1 in the survival of hematopoietic stem cells.
Science (New York, N.Y.) 2005;307(5712):1101-4.
2005: Jing Wang; Hiromi Iwasaki; Andrei V Krivtsov; Phillip G Febbo; Aaron R Thorner; Patricia Ernst; Ema Anastasiadou; Jeffery L Kutok; Scott C Kogan; Sandra S Zinkel; Jill K Fisher; Jay L Hess; Todd R Golub; Scott A Armstrong; Koichi Akashi; Stanley J Korsmeyer
Conditional MLL-CBP targets GMP and models therapy-related myeloproliferative disease.
The EMBO journal 2005;24(2):368-81.
2005: Kyoung Joon Oh; Scott Barbuto; Natalie Meyer; Ryung S. Kim; R. John Collier; Stanley J Korsmeyer
Conformational changes in BID, a pro-apoptotic BCL-2 family member, upon membrane binding. A site-directed spin labeling study.
The Journal of biological chemistry 2005;280(1):753-67.
2005: Scott A Oakes; LUCA SCORRANO; Joseph T Opferman; Michael C Bassik; Mari Nishino; Tullio Pozzan; Stanley J Korsmeyer
Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(1):105-10.
2004: Patricia Ernst; Meghann Mabon; Alan J Davidson; Leonard I Zon; Stanley J Korsmeyer
An Mll-dependent Hox program drives hematopoietic progenitor expansion.
Current biology : CB 2004;14(22):2063-9.
2004: Mayra Mori; Daniel L Burgess; LA Gefrides; PERRY FOREMAN; J T Opferman; Stanley J Korsmeyer; Esper A. Cavalheiro; Md G Naffah-Mazzacoratti; Jeffrey L Noebels
Expression of apoptosis inhibitor protein Mcl1 linked to neuroprotection in CNS neurons.
Cell death and differentiation 2004;11(11):1223-33.
2004: Hisashi Harada; Bonnie Quearry; Antonio Ruiz-Vela; Stanley J Korsmeyer
Survival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(43):15313-7.
2004: Scott A Oakes; Stanley J Korsmeyer
Untangling the web: mitochondrial fission and apoptosis.
Developmental cell 2004;7(4):460-2.
2004: So Young Seo; Ying-bei Chen; Iva Ivanovska; Ann M Ranger; Suk Hong; Valina Dawson; Stanley J Korsmeyer; David S Bellows; Yihru Fannjiang; J Marie Hardwick
BAD is a pro-survival factor prior to activation of its pro-apoptotic function.
The Journal of biological chemistry 2004;279(40):42240-9.
2004: Young-Jae Nam; Kartik Mani; Anthony W Ashton; Chang-Fu Peng; Barath Krishnamurthy; Yukihiro Hayakawa; Peiyee Lee; Stanley J Korsmeyer; Richard N Kitsis
Inhibition of both the extrinsic and intrinsic death pathways through nonhomotypic death-fold interactions.
Molecular cell 2004;15(6):901-12.
2004: Loren D Walensky; Andrew L Kung; Iris Escher; Thomas J Malia; Scott Barbuto; Renee D Wright; Gerhard Wagner; Gregory L Verdine; Stanley J Korsmeyer
Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix.
Science (New York, N.Y.) 2004;305(5689):1466-70.
2004: Anthony Letai; Mia D Sorcinelli; Caroline Beard; Stanley J Korsmeyer
Antiapoptotic BCL-2 is required for maintenance of a model leukemia.
Cancer cell 2004;6(3):241-9.
2004: Liang Guo; Dawn Pietkiewicz; Evgeny V Pavlov; Sergey M Grigoriev; John Kasianowicz; Laurent M Dejean; Stanley J Korsmeyer; Bruno Antonsson; Kathleen W Kinnally
Effects of cytochrome c on the mitochondrial apoptosis-induced channel MAC.
American journal of physiology. Cell physiology 2004;286(5):C1109-17.
2004: Scott A Armstrong; Meghann E Mabon; Lewis B Silverman; Aihong Li; John G Gribben; Edward A Fox; Stephen E Sallan; Stanley J Korsmeyer
FLT3 mutations in childhood acute lymphoblastic leukemia.
Blood 2004;103(9):3544-6.
2004: Michael C Bassik; LUCA SCORRANO; Scott A Oakes; Tullio Pozzan; Stanley J Korsmeyer
Phosphorylation of BCL-2 regulates ER Ca2+ homeostasis and apoptosis.
The EMBO journal 2004;23(5):1207-16.
2004: Patricia Ernst; Jill K Fisher; William Avery; Stacey Wade; Daniel Foy; Stanley J Korsmeyer
Definitive hematopoiesis requires the mixed-lineage leukemia gene.
Developmental cell 2004;6(3):437-43.
2004: Nika N Danial; Stanley J Korsmeyer
Cell death: critical control points.
Cell 2004;116(2):205-19.
2003: Arturo Chavez-Reyes; John M Parant; Lisa L Amelse; Roberto Montes de Oca Luna; Stanley J Korsmeyer; Guillermina Lozano
Switching mechanisms of cell death in mdm2- and mdm4-null mice by deletion of p53 downstream targets.
Cancer research 2003;63(24):8664-9.
2003: Joseph T Opferman; Anthony Letai; Caroline Beard; Mia D Sorcinelli; Christy C Ong; Stanley J Korsmeyer
Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1.
Nature 2003;426(6967):671-6.
2003: Cleta D'Sa; Barbara J Klocke; Francesco Cecconi; Tullia Lindsten; Craig Thompson; Stanley J Korsmeyer; Richard A Flavell; Kevin A Roth
Caspase regulation of genotoxin-induced neural precursor cell death.
Journal of neuroscience research 2003;74(3):435-45.
2003: James Hsieh; Emily Cheng; Stanley J Korsmeyer
Taspase1: a threonine aspartase required for cleavage of MLL and proper HOX gene expression.
Cell 2003;115(3):293-303.
2003: Scott A Oakes; Joseph T Opferman; Tullio Pozzan; Stanley J Korsmeyer; LUCA SCORRANO
Regulation of endoplasmic reticulum Ca2+ dynamics by proapoptotic BCL-2 family members.
Biochemical pharmacology 2003;66(8):1335-40.
2003: Scott A Armstrong; Todd R Golub; Stanley J Korsmeyer
MLL-rearranged leukemias: insights from gene expression profiling.
Seminars in hematology 2003;40(4):268-73.
2003: Hongxin Dong; Alicia Fazzaro; Chuanxi Xiang; Stanley J Korsmeyer; Mark F Jacquin; JOHN MCDONALD
Enhanced oligodendrocyte survival after spinal cord injury in Bax-deficient mice and mice with delayed Wallerian degeneration.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(25):8682-91.
2003: Alan J Davidson; Patricia Ernst; Yuan Wang; Marcus P S Dekens; Paul D Kingsley; James Palis; Stanley J Korsmeyer; George Q Daley; Leonard I Zon
cdx4 mutants fail to specify blood progenitors and can be rescued by multiple hox genes.
Nature 2003;425(6955):300-6.
2003: Scott A Armstrong; Stanley J Korsmeyer
Comparison of human genomics and genetic models of cancer to identify novel therapeutic targets.
Cell cycle (Georgetown, Tex.) 2003;2(5):408-9.
2003: Nika N Danial; Colette F Gramm; LUCA SCORRANO; Chen-Yu zhang; Stefan Krauss; Ann M Ranger; Sandeep Robert Datta; Michael E Greenberg; Lawrence J Licklider; Bradford B Lowell; Steven P Gygi; Stanley J Korsmeyer
BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis.
Nature 2003;424(6951):952-6.
2003: Ann M Ranger; Jiping Zha; Hisashi Harada; Sandeep Robert Datta; Nika N Danial; Andrew P Gilmore; Jeffery L Kutok; Michelle M Le Beau; Michael E Greenberg; Stanley J Korsmeyer
Bad-deficient mice develop diffuse large B cell lymphoma.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(16):9324-9.
2003: Emily Cheng; Tatiana V Sheiko; Jill K Fisher; William J Craigen; Stanley J Korsmeyer
VDAC2 inhibits BAK activation and mitochondrial apoptosis.
Science (New York, N.Y.) 2003;301(5632):513-7.
2003: Adolfo Ferrando; Scott A Armstrong; Donna Neuberg; Stephen E Sallan; Lewis B Silverman; Stanley J Korsmeyer; A Thomas Look
Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias: dominance of HOX dysregulation.
Blood 2003;102(1):262-8.
2003: LUCA SCORRANO; Stanley J Korsmeyer
Mechanisms of cytochrome c release by proapoptotic BCL-2 family members.
Biochemical and biophysical research communications 2003;304(3):437-44.
2003: Joseph T Opferman; Stanley J Korsmeyer
Apoptosis in the development and maintenance of the immune system.
Nature immunology 2003;4(5):410-5.
2003: Hillary Johnson; LUCA SCORRANO; Stanley J Korsmeyer; Timothy J Ley
Cell death induced by granzyme C.
Blood 2003;101(8):3093-101.
2003: LUCA SCORRANO; Scott A Oakes; Joseph T Opferman; Emily Cheng; Mia D Sorcinelli; Tullio Pozzan; Stanley J Korsmeyer
BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis.
Science (New York, N.Y.) 2003;300(5616):135-9.
2003: Karthikeyan Kandasamy; Srinivasa M Srinivasula; Emad S Alnemri; Craig Thompson; Stanley J Korsmeyer; Joseph L Bryant; Rakesh K Srivastava
Involvement of proapoptotic molecules Bax and Bak in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced mitochondrial disruption and apoptosis: differential regulation of cytochrome c and Smac/DIABLO release.
Cancer research 2003;63(7):1712-21.
2003: Jean-Luc PERFETTINI; David M Ojcius; Charles W Andrews; Stanley J Korsmeyer; Roger Rank; Toni Darville
Role of proapoptotic BAX in propagation of Chlamydia muridarum (the mouse pneumonitis strain of Chlamydia trachomatis) and the host inflammatory response.
The Journal of biological chemistry 2003;278(11):9496-502.
2003: Ronald W Stam; Monique L den Boer; Jules P P Meijerink; Marli E G Ebus; Godefridus J Peters; Paul Noordhuis; Gritta E Janka-Schaub; Scott A Armstrong; Stanley J Korsmeyer; Rob Pieters
Differential mRNA expression of Ara-C-metabolizing enzymes explains Ara-C sensitivity in MLL gene-rearranged infant acute lymphoblastic leukemia.
Blood 2003;101(4):1270-6.
2003: Scott A Armstrong; Andrew L Kung; Meghann E Mabon; Lewis B Silverman; Ronald W Stam; Monique L den Boer; Rob Pieters; John H Kersey; Stephen E Sallan; Jonathan A Fletcher; Todd R Golub; James D Griffin; Stanley J Korsmeyer
Inhibition of FLT3 in MLL. Validation of a therapeutic target identified by gene expression based classification.
Cancer cell 2003;3(2):173-83.
2003: Sandra S Zinkel; Christy C Ong; David O Ferguson; Hiromi Iwasaki; Koichi Akashi; Roderick T Bronson; Jeffery L Kutok; Frederick W Alt; Stanley J Korsmeyer
Proapoptotic BID is required for myeloid homeostasis and tumor suppression.
Genes & development 2003;17(2):229-39.
2003: Yasushi Takai; Jacqueline Canning; Gloria I Perez; James K Pru; Jennifer J Schlezinger; David H Sherr; Richard Kolesnick; Junying Yuan; Richard A Flavell; Stanley J Korsmeyer; Jonathan L Tilly
Bax, caspase-2, and caspase-3 are required for ovarian follicle loss caused by 4-vinylcyclohexene diepoxide exposure of female mice in vivo.
Endocrinology 2003;144(1):69-74.
2003: James Hsieh; Patricia Ernst; Hediye Erdjument-Bromage; Paul Tempst; Stanley J Korsmeyer
Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization.
Molecular and cellular biology 2003;23(1):186-94.
2002: Sandeep Robert Datta; Ann M Ranger; Michael Z Lin; James Fitzhugh Sturgill; Yong-Chao Ma; Christopher William Cowan; Pieter Dikkes; Stanley J Korsmeyer; Michael E Greenberg
Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis.
Developmental cell 2002;3(5):631-43.
2002: Joanna K Sax; Peiwen Fei; Maureen E Murphy; Eric J Bernhard; Stanley J Korsmeyer; Wafik S El-Deiry
BID regulation by p53 contributes to chemosensitivity.
Nature cell biology 2002;4(11):842-9.
2002: Anthony Letai; Michael C Bassik; Loren D Walensky; Mia D Sorcinelli; Solly Weiler; Stanley J Korsmeyer
Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics.
Cancer cell 2002;2(3):183-92.
2002: Philippe Juin; Abigail Hunt; Trevor Littlewood; Beatrice Griffiths; Lamorna Brown Swigart; Stanley J Korsmeyer; Gerard I Evan
c-Myc functionally cooperates with Bax to induce apoptosis.
Molecular and cellular biology 2002;22(17):6158-69.
2002: Andrew P Gilmore; Anthony J Valentijn; Pengbo Wang; Ann M Ranger; Nigel Bundred; Michael J O'Hare; Alan Wakeling; Stanley J Korsmeyer; Charles H Streuli
Activation of BAD by therapeutic inhibition of epidermal growth factor receptor and transactivation by insulin-like growth factor receptor.
The Journal of biological chemistry 2002;277(31):27643-50.
2002: Valeria R Fantin; Marcelo J Berardi; LUCA SCORRANO; Stanley J Korsmeyer; Philip Leder
A novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth.
Cancer cell 2002;2(1):29-42.
2002: Scott A Armstrong; James Hsieh; Stanley J Korsmeyer
Genomic approaches to the pathogenesis and treatment of acute lymphoblastic leukemias.
Current opinion in hematology 2002;9(4):339-44.
2002: Patricia Ernst; Jing Wang; Stanley J Korsmeyer
The role of MLL in hematopoiesis and leukemia.
Current opinion in hematology 2002;9(4):282-7.
2002: Gaël G McGill; Martin A Horstmann; Hans R Widlund; Jinyan Du; Gabriela Motyckova; Emi K Nishimura; Yi-Ling Lin; Sridhar Ramaswamy; William Avery; Hanfei Ding; Siobhán A Jordan; Ian J Jackson; Stanley J Korsmeyer; Todd R Golub; David E Fisher
Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability.
Cell 2002;109(6):707-18.
2002: Christine M Eischen; Jerold E Rehg; Stanley J Korsmeyer; John L Cleveland
Loss of Bax alters tumor spectrum and tumor numbers in ARF-deficient mice.
Cancer research 2002;62(7):2184-91.
2002: Lonnie D Russell; Hélio Chiarini-Garcia; Stanley J Korsmeyer; C Michael Knudson
Bax-dependent spermatogonia apoptosis is required for testicular development and spermatogenesis.
Biology of reproduction 2002;66(4):950-8.
2002: Tiina Matikainen; Toshitake Moriyama; Yutaka Morita; Gloria I Perez; Stanley J Korsmeyer; David H Sherr; Jonathan L Tilly
Ligand activation of the aromatic hydrocarbon receptor transcription factor drives Bax-dependent apoptosis in developing fetal ovarian germ cells.
Endocrinology 2002;143(2):615-20.
2002: Nikolaus Plesnila; Sandra Zinkel; Sepideh Amin-Hanjani; Jianhua Qiu; Stanley J Korsmeyer; Michael A Moskowitz
Function of BID -- a molecule of the bcl-2 family -- in ischemic cell death in the brain.
European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes 2002;34(1-2):37-41.
2002: LUCA SCORRANO; Mona Ashiya; Karolyn F Buttle; Solly Weiler; Scott A Oakes; Carmen A Mannella; Stanley J Korsmeyer
A distinct pathway remodels mitochondrial cristae and mobilizes cytochrome c during apoptosis.
Developmental cell 2002;2(1):55-67.
2002: Scott A Armstrong; Jane E Staunton; Lewis B Silverman; Rob Pieters; Monique L den Boer; Mark D Minden; Stephen E Sallan; Eric S Lander; Todd R Golub; Stanley J Korsmeyer
MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia.
Nature genetics 2002;30(1):41-7.
2001: Nikolaus Plesnila; S Zinkel; Dean A Le; Sepideh Amin-Hanjani; Yaotang Wu; Jianhua Qiu; A Chiarugi; Sunu S Thomas; Daniel S Kohane; Stanley J Korsmeyer; Michael A Moskowitz
BID mediates neuronal cell death after oxygen/ glucose deprivation and focal cerebral ischemia.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(26):15318-23.
2001: Evgeny V Pavlov; Muriel Priault; Dawn Pietkiewicz; Emily Cheng; Bruno Antonsson; Stéphen Manon; Stanley J Korsmeyer; Carmen A Mannella; Kathleen W Kinnally
A novel, high conductance channel of mitochondria linked to apoptosis in mammalian cells and Bax expression in yeast.
The Journal of cell biology 2001;155(5):725-31.
2001: AJ Ross; S P Amy; Patryce L Mahar; Tullia Lindsten; C M Knudson; Craig Thompson; Stanley J Korsmeyer; Grant R MacGregor
BCLW mediates survival of postmitotic Sertoli cells by regulating BAX activity.
Developmental biology 2001;239(2):295-308.
2001: Christine M Eischen; Martine F Roussel; Stanley J Korsmeyer; John L Cleveland
Bax loss impairs Myc-induced apoptosis and circumvents the selection of p53 mutations during Myc-mediated lymphomagenesis.
Molecular and cellular biology 2001;21(22):7653-62.
2001: AU Zaidi; J S McDonough; Barbara J Klocke; Cecelia B Latham; Stanley J Korsmeyer; Richard A Flavell; Robert E Schmidt; Kevin A Roth
Chloroquine-induced neuronal cell death is p53 and Bcl-2 family-dependent but caspase-independent.
Journal of neuropathology and experimental neurology 2001;60(10):937-45.
2001: Emily Cheng; Michael Wei; Solly Weiler; R A Flavell; T W Mak; Tullia Lindsten; Stanley J Korsmeyer
BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis.
Molecular cell 2001;8(3):705-11.
2001: H Harada; J S Andersen; M Mann; N Terada; Stanley J Korsmeyer
p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(17):9666-70.
2001: Tiina Matikainen; Gloria I Perez; Andrea Jurisicova; James K Pru; Jennifer J Schlezinger; Heui-Young Ryu; Jarmo Laine; T Sakai; Stanley J Korsmeyer; Robert Casper; David H Sherr; Jonathan L Tilly
Aromatic hydrocarbon receptor-driven Bax gene expression is required for premature ovarian failure caused by biohazardous environmental chemicals.
Nature genetics 2001;28(4):355-60.
2001: Jeffrey R Leonard; Cleta D'Sa; B R Cahn; Stanley J Korsmeyer; Kevin A Roth
Bid regulation of neuronal apoptosis.
Brain research. Developmental brain research 2001;128(2):187-90.
2001: Y Morita; DV Maravei; L Bergeron; S Wang; Gloria I Perez; O Tsutsumi; Y Taketani; M Asano; R Horai; Stanley J Korsmeyer; Y Iwakura; Junying Yuan; Jonathan L Tilly
Caspase-2 deficiency prevents programmed germ cell death resulting from cytokine insufficiency but not meiotic defects caused by loss of ataxia telangiectasia-mutated (Atm) gene function.
Cell death and differentiation 2001;8(6):614-20.
2001: A M Ranger; Barbara A Malynn; Stanley J Korsmeyer
Mouse models of cell death.
Nature genetics 2001;28(2):113-8.
2001: Michael Wei; Wei-Xing Zong; Emily Cheng; Tullia Lindsten; V Panoutsakopoulou; AJ Ross; Kevin A Roth; Grant R MacGregor; Craig Thompson; Stanley J Korsmeyer
Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death.
Science (New York, N.Y.) 2001;292(5517):727-30.
2001: Patricia Ernst; J Wang; M Huang; Richard H Goodman; Stanley J Korsmeyer
MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein.
Molecular and cellular biology 2001;21(7):2249-58.
2001: V K Mootha; Michael Wei; Karolyn F Buttle; LUCA SCORRANO; V Panoutsakopoulou; Carmen A Mannella; Stanley J Korsmeyer
A reversible component of mitochondrial respiratory dysfunction in apoptosis can be rescued by exogenous cytochrome c.
The EMBO journal 2001;20(4):661-71.
2001: Renren Wen; Denan Wang; Catriona McKay; Kevin D Bunting; Jean-Christophe Marine; E F Vanin; Gerard P Zambetti; Stanley J Korsmeyer; James N Ihle; John L Cleveland
Jak3 selectively regulates Bax and Bcl-2 expression to promote T-cell development.
Molecular and cellular biology 2001;21(2):678-89.
2000: Stanley J Korsmeyer; Michael Wei; M Saito; Solly Weiler; K J Oh; P H Schlesinger
Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c.
Cell death and differentiation 2000;7(12):1166-73.
2000: Tullia Lindsten; AJ Ross; A King; Wei-Xing Zong; Jeffrey C Rathmell; HA Shiels; E Ulrich; Katrina G Waymire; Patryce L Mahar; Kenneth A Frauwirth; Youhai Chen; Michael Wei; V M Eng; David M Adelman; M Celeste Simon; A Ma; Jeffrey A Golden; Gerard I Evan; Stanley J Korsmeyer; Grant R MacGregor; Craig Thompson
The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues.
Molecular cell 2000;6(6):1389-99.
2000: J Zha; Solly Weiler; K J Oh; Michael Wei; Stanley J Korsmeyer
Posttranslational N-myristoylation of BID as a molecular switch for targeting mitochondria and apoptosis.
Science (New York, N.Y.) 2000;290(5497):1761-5.
2000: Michael Wei; Tullia Lindsten; V K Mootha; Solly Weiler; A Gross; Mona Ashiya; Craig Thompson; Stanley J Korsmeyer
tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c.
Genes & development 2000;14(16):2060-71.
2000: A Gross; K Pilcher; Elizabeth Blachly-Dyson; Emy Basso; J Jockel; M C Bassik; Stanley J Korsmeyer; Michael Forte
Biochemical and genetic analysis of the mitochondrial response of yeast to BAX and BCL-X(L).
Molecular and cellular biology 2000;20(9):3125-36.
2000: S Shirasawa; Akiko Arata; Hiroshi Onimaru; Kevin A Roth; G A Brown; S Horning; Satoru Arata; K Okumura; T Sasazuki; Stanley J Korsmeyer
Rnx deficiency results in congenital central hypoventilation.
Nature genetics 2000;24(3):287-90.
1999: R D Hanson; Jay L Hess; Benjamin Yu; Patricia Ernst; M van Lohuizen; Anton Berns; NM Van der Lugt; Cooduvalli S Shashikant; Frank H Ruddle; M Seto; Stanley J Korsmeyer
Mammalian Trithorax and polycomb-group homologues are antagonistic regulators of homeotic development.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(25):14372-7.
1999: DM Pritchard; Christopher S Potten; Stanley J Korsmeyer; Steve Roberts; John A Hickman
Damage-induced apoptosis in intestinal epithelia from bcl-2-null and bax-null mice: investigations of the mechanistic determinants of epithelial apoptosis in vivo.
Oncogene 1999;18(51):7287-93.
1999: K Yamamoto; H Ichijo; Stanley J Korsmeyer
BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M.
Molecular and cellular biology 1999;19(12):8469-78.
1999: X M Yin; K Wang; A Gross; Y Zhao; S Zinkel; Barbara J Klocke; Kevin A Roth; Stanley J Korsmeyer
Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis.
Nature 1999;400(6747):886-91.
1999: J Lewis; George A Oyler; K Ueno; Yihru Fannjiang; BN Chau; J Vornov; Stanley J Korsmeyer; Shifa Zou; J Marie Hardwick
Inhibition of virus-induced neuronal apoptosis by Bax.
Nature medicine 1999;5(7):832-5.
1999: Kristel Schorr; Minglin Li; U Bar-Peled; A Lewis; Alonso Heredia; B Lewis; C M Knudson; Stanley J Korsmeyer; richard jäger; Hans Weiher; Priscilla A Furth
Gain of Bcl-2 is more potent than bax loss in regulating mammary epithelial cell survival in vivo.
Cancer research 1999;59(11):2541-5.
1999: H Harada; B Becknell; M Wilm; M Mann; L J Huang; S S Taylor; John D Scott; Stanley J Korsmeyer
Phosphorylation and inactivation of BAD by mitochondria-anchored protein kinase A.
Molecular cell 1999;3(4):413-22.
1999: Stanley J Korsmeyer
BCL-2 gene family and the regulation of programmed cell death.
Cancer research 1999;59(7 Suppl):1693s-1700s.
1999: O Bar-Peled; M Knudson; Stanley J Korsmeyer; Jeffrey rothstein
Motor neuron degeneration is attenuated in bax-deficient neurons in vitro.
Journal of neuroscience research 1999;55(5):542-56.
1999: Gloria I Perez; R Robles; C M Knudson; Jodi A Flaws; Stanley J Korsmeyer; Jonathan L Tilly
Prolongation of ovarian lifespan into advanced chronological age by Bax-deficiency.
Nature genetics 1999;21(2):200-3.
1999: A Gross; X M Yin; K Wang; Michael Wei; J Jockel; C Milliman; H Erdjument-Bromage; Paul Tempst; Stanley J Korsmeyer
Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death.
The Journal of biological chemistry 1999;274(2):1156-63.
1999: Stanley J Korsmeyer
Programmed cell death and the regulation of homeostasis.
Harvey lectures 1999;95():21-41.
1999: Stanley J Korsmeyer; A Gross; H Harada; J Zha; K Wang; X M Yin; Michael Wei; S Zinkel
Death and survival signals determine active/inactive conformations of pro-apoptotic BAX, BAD, and BID molecules.
Cold Spring Harbor symposia on quantitative biology 1999;64():343-50.
1998: Benjamin Yu; R D Hanson; Jay L Hess; S E Horning; Stanley J Korsmeyer
MLL, a mammalian trithorax-group gene, functions as a transcriptional maintenance factor in morphogenesis.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(18):10632-6.
1998: A Gross; J Jockel; Michael Wei; Stanley J Korsmeyer
Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis.
The EMBO journal 1998;17(14):3878-85.
1998: D T Chao; Stanley J Korsmeyer
BCL-2 family: regulators of cell death.
Annual review of immunology 1998;16():395-419.
1997: Gloria I Perez; C M Knudson; L Leykin; Stanley J Korsmeyer; Jonathan L Tilly
Apoptosis-associated signaling pathways are required for chemotherapy-mediated female germ cell destruction.
Nature medicine 1997;3(11):1228-32.
1997: P H Schlesinger; A Gross; X M Yin; K Yamamoto; M Saito; G Waksman; Stanley J Korsmeyer
Comparison of the ion channel characteristics of proapoptotic BAX and antiapoptotic BCL-2.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(21):11357-62.
1997: J Zha; H Harada; K Osipov; J Jockel; Gabriel Waksman; Stanley J Korsmeyer
BH3 domain of BAD is required for heterodimerization with BCL-XL and pro-apoptotic activity.
The Journal of biological chemistry 1997;272(39):24101-4.
1997: D T Chao; Stanley J Korsmeyer
BCL-XL-regulated apoptosis in T cell development.
International immunology 1997;9(9):1375-84.
1997: Jay L Hess; Benjamin Yu; B Li; R Hanson; Stanley J Korsmeyer
Defects in yolk sac hematopoiesis in Mll-null embryos.
Blood 1997;90(5):1799-806.
1997: T Kawabe; A J Muslin; Stanley J Korsmeyer
HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint.
Nature 1997;385(6615):454-8.
1997: Diane E Merry; Stanley J Korsmeyer
Bcl-2 gene family in the nervous system.
Annual review of neuroscience 1997;20():245-67.
1996: J Xiang; D T Chao; Stanley J Korsmeyer
BAX-induced cell death may not require interleukin 1 beta-converting enzyme-like proteases.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(25):14559-63.
1996: J Zha; H Harada; E Yang; J Jockel; Stanley J Korsmeyer
Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)
Cell 1996;87(4):619-28.
1996: K Wang; X M Yin; D T Chao; C L Milliman; Stanley J Korsmeyer
BID: a novel BH3 domain-only death agonist.
Genes & development 1996;10(22):2859-69.
1996: G P Linette; Y Li; K Roth; Stanley J Korsmeyer
Cross talk between cell death and cell cycle progression: BCL-2 regulates NFAT-mediated activation.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(18):9545-52.
1996: E Yang; Stanley J Korsmeyer
Molecular thanatopsis: a discourse on the BCL2 family and cell death.
Blood 1996;88(2):386-401.
1995: Benjamin Yu; Jay L Hess; S E Horning; G A Brown; Stanley J Korsmeyer
Altered Hox expression and segmental identity in Mll-mutant mice.
Nature 1995;378(6556):505-8.
1995: C M Knudson; K S Tung; W G Tourtellotte; G A Brown; Stanley J Korsmeyer
Bax-deficient mice with lymphoid hyperplasia and male germ cell death.
Science (New York, N.Y.) 1995;270(5233):96-9.
1995: D T Chao; G P Linette; Lawrence Boise; LS White; Craig Thompson; Stanley J Korsmeyer
Bcl-XL and Bcl-2 repress a common pathway of cell death.
The Journal of experimental medicine 1995;182(3):821-8.
1995: Thomas W Sedlak; Zoltan N. Oltvai; E Yang; K Wang; Lawrence Boise; Craig Thompson; Stanley J Korsmeyer
Multiple Bcl-2 family members demonstrate selective dimerizations with Bax.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(17):7834-8.
1995: G P Linette; Jay L Hess; charles sentman; Stanley J Korsmeyer
Peripheral T-cell lymphoma in lckpr-bcl-2 transgenic mice.
Blood 1995;86(4):1255-60.
1995: Stanley J Korsmeyer; X M Yin; Zoltan N. Oltvai; D J Veis-Novack; G P Linette
Reactive oxygen species and the regulation of cell death by the Bcl-2 gene family.
Biochimica et biophysica acta 1995;1271(1):63-6.
1995: E Yang; J Zha; J Jockel; Lawrence Boise; Craig Thompson; Stanley J Korsmeyer
Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death.
Cell 1995;80(2):285-91.
1995: X M Yin; Zoltan N. Oltvai; Stanley J Korsmeyer
Heterodimerization with Bax is required for Bcl-2 to repress cell death.
Current topics in microbiology and immunology 1995;194():331-8.
1995: Christine M Sorenson; Sharon A Rogers; Stanley J Korsmeyer; Marc R Hammerman
Fulminant metanephric apoptosis and abnormal kidney development in bcl-2-deficient mice.
The American journal of physiology 1995;268(1 Pt 2):F73-81.
1994: Hyeong-Reh Choi Kim; S Upadhyay; Stanley J Korsmeyer; T F Deuel
Platelet-derived growth factor (PDGF) B and A homodimers transform murine fibroblasts depending on the genetic background of the cell.
The Journal of biological chemistry 1994;269(48):30604-8.
1994: G P Linette; Michael J Grusby; S M Hedrick; T H Hansen; Laurie H Glimcher; Stanley J Korsmeyer
Bcl-2 is upregulated at the CD4+ CD8+ stage during positive selection and promotes thymocyte differentiation at several control points.
Immunity 1994;1(3):197-205.
1994: X M Yin; Zoltan N. Oltvai; Stanley J Korsmeyer
BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax.
Nature 1994;369(6478):321-3.
1994: D E Merry; D J Veis; W F Hickey; Stanley J Korsmeyer
bcl-2 protein expression is widespread in the developing nervous system and retained in the adult PNS.
Development (Cambridge, England) 1994;120(2):301-11.
1994: X M Yin; Zoltan N. Oltvai; D J Veis-Novack; G P Linette; Stanley J Korsmeyer
Bcl-2 gene family and the regulation of programmed cell death.
Cold Spring Harbor symposia on quantitative biology 1994;59():387-93.
1993: Stanley J Korsmeyer; J R Shutter; D J Veis; D E Merry; Zoltan N. Oltvai
Bcl-2/Bax: a rheostat that regulates an anti-oxidant pathway and cell death.
Seminars in cancer biology 1993;4(6):327-32.
1993: D J Veis; C M Sorenson; J R Shutter; Stanley J Korsmeyer
Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair.
Cell 1993;75(2):229-40.
1993: David M Hockenbery; Zoltan N. Oltvai; X M Yin; C L Milliman; Stanley J Korsmeyer
Bcl-2 functions in an antioxidant pathway to prevent apoptosis.
Cell 1993;75(2):241-51.
1993: D J Veis; charles sentman; Erika A Bach; Stanley J Korsmeyer
Expression of the Bcl-2 protein in murine and human thymocytes and in peripheral T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(5):2546-54.
1993: Zoltan N. Oltvai; C L Milliman; Stanley J Korsmeyer
Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death.
Cell 1993;74(4):609-19.
1993: P H Domer; S S Fakharzadeh; C S Chen; J Jockel; L Johansen; Gary A Silverman; J H Kersey; Stanley J Korsmeyer
Acute mixed-lineage leukemia t(4;11)(q21;q23) generates an MLL-AF4 fusion product.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(16):7884-8.
1993: R L Young; Stanley J Korsmeyer
A negative regulatory element in the bcl-2 5'-untranslated region inhibits expression from an upstream promoter.
Molecular and cellular biology 1993;13(6):3686-97.
1992: E A McGuire; C E Rintoul; G M Sclar; Stanley J Korsmeyer
Thymic overexpression of Ttg-1 in transgenic mice results in T-cell acute lymphoblastic leukemia/lymphoma.
Molecular and cellular biology 1992;12(9):4186-96.
1992: Stanley J Korsmeyer
Bcl-2 initiates a new category of oncogenes: regulators of cell death.
Blood 1992;80(4):879-86.
1992: Stanley J Korsmeyer
Chromosomal translocations in lymphoid malignancies reveal novel proto-oncogenes.
Annual review of immunology 1992;10():785-807.
1992: Stanley J Korsmeyer
Bcl-2: an antidote to programmed cell death.
Cancer surveys 1992;15():105-18.
1991: charles sentman; J R Shutter; David M Hockenbery; O Kanagawa; Stanley J Korsmeyer
bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes.
Cell 1991;67(5):879-88.
1991: G Nuñez; David M Hockenbery; Timothy J McDonnell; C M Sorensen; Stanley J Korsmeyer
Bcl-2 maintains B cell memory.
Nature 1991;353(6339):71-3.
1991: David M Hockenbery; MM Zutter; W Hickey; Moon H Nahm; Stanley J Korsmeyer
BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(16):6961-5.
1991: M Zutter; David M Hockenbery; Gary A Silverman; Stanley J Korsmeyer
Immunolocalization of the Bcl-2 protein within hematopoietic neoplasms.
Blood 1991;78(4):1062-8.
1991: M Hatano; C W Roberts; M Minden; W M Crist; Stanley J Korsmeyer
Deregulation of a homeobox gene, HOX11, by the t(10;14) in T cell leukemia.
Science (New York, N.Y.) 1991;253(5015):79-82.
1991: Gary A Silverman; J I Jockel; P H Domer; R M Mohr; P Taillon-Miller; Stanley J Korsmeyer
Yeast artificial chromosome cloning of a two-megabase-size contig within chromosomal band 18q21 establishes physical linkage between BCL2 and plasminogen activator inhibitor type-2.
Genomics 1991;9(2):219-28.
1991: E A McGuire; A R Davis; Stanley J Korsmeyer
T-cell translocation gene 1 (Ttg-1) encodes a nuclear protein normally expressed in neural lineage cells.
Blood 1991;77(3):599-606.
1991: Timothy J McDonnell; Stanley J Korsmeyer
Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14; 18).
Nature 1991;349(6306):254-6.
1990: Gary A Silverman; Eric Green; R L Young; J I Jockel; P H Domer; Stanley J Korsmeyer
Meiotic recombination between yeast artificial chromosomes yields a single clone containing the entire BCL2 protooncogene.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(24):9913-7.
1990: David M Hockenbery; G Nuñez; C Milliman; R D Schreiber; Stanley J Korsmeyer
Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death.
Nature 1990;348(6299):334-6.
1990: G Nuñez; L London; David M Hockenbery; M Alexander; John P McKearn; Stanley J Korsmeyer
Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(9):3602-10.
1990: Timothy J McDonnell; Gabriel Nunez; F M Platt; D Hockenberry; L London; John P McKearn; Stanley J Korsmeyer
Deregulated Bcl-2-immunoglobulin transgene expands a resting but responsive immunoglobulin M and D-expressing B-cell population.
Molecular and cellular biology 1990;10(5):1901-7.
1990: MM Zutter; RD Hockett; C W Roberts; E A McGuire; J Bloomstone; C C Morton; L L Deaven; W M Crist; A J Carroll; Stanley J Korsmeyer
The t(10;14)(q24;q11) of T-cell acute lymphoblastic leukemia juxtaposes the delta T-cell receptor with TCL3, a conserved and activated locus at 10q24.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(8):3161-5.
1990: Stanley J Korsmeyer; Timothy J McDonnell; G Nunez; David M Hockenbery; R Young
Bcl-2: B cell life, death and neoplasia.
Current topics in microbiology and immunology 1990;166():203-7.
1989: R D Hockett; G Nuñez; Stanley J Korsmeyer
Evolutionary comparison of murine and human delta T-cell receptor deleting elements.
The New biologist 1989;1(3):266-74.
1989: G A Silverman; Richard D Ye; K M Pollock; J Evan Sadler; Stanley J Korsmeyer
Use of yeast artificial chromosome clones for mapping and walking within human chromosome segment 18q21.3.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(19):7485-9.
1989: Gabriel Nunez; M Seto; S Seremetis; D Ferrero; F Grignani; Stanley J Korsmeyer; R Dalla-Favera
Growth- and tumor-promoting effects of deregulated BCL2 in human B-lymphoblastoid cells.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(12):4589-93.
1989: E A McGuire; RD Hockett; K M Pollock; M F Bartholdi; S J O'Brien; Stanley J Korsmeyer
The t(11;14)(p15;q11) in a T-cell acute lymphoblastic leukemia cell line activates multiple transcripts, including Ttg-1, a gene encoding a potential zinc finger protein.
Molecular and cellular biology 1989;9(5):2124-32.
1989: Timothy J McDonnell; N Deane; F M Platt; Gabriel Nunez; U Jaeger; John P McKearn; Stanley J Korsmeyer
bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation.
Cell 1989;57(1):79-88.
1988: RD Hockett; Jean-Pierre De Villartay; K Pollock; David G Poplack; D I Cohen; Stanley J Korsmeyer
Human T-cell antigen receptor (TCR) delta-chain locus and elements responsible for its deletion are within the TCR alpha-chain locus.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(24):9694-8.
1988: Jean-Pierre De Villartay; RD Hockett; D Coran; Stanley J Korsmeyer; D I Cohen
Deletion of the human T-cell receptor delta-gene by a site-specific recombination.
Nature 1988;335(6186):170-4.
1988: P Guglielmi; A Bakhshi; M Cogne; M Seligmann; Stanley J Korsmeyer
Multiple genomic defects result in an alternative RNA splice creating a human gamma H chain disease protein.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(5):1762-8.
1988: Michel Cogné; A Bakhshi; Stanley J Korsmeyer; P Guglielmi
Gene mutations and alternate RNA splicing result in truncated Ig L chains in human gamma H chain disease.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(5):1738-44.
1988: M Crescenzi; M Seto; G P Herzig; P D Weiss; R C Griffith; Stanley J Korsmeyer
Thermostable DNA polymerase chain amplification of t(14;18) chromosome breakpoints and detection of minimal residual disease.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(13):4869-73.
1988: W B Graninger; P L Goldman; C C Morton; S J O'Brien; Stanley J Korsmeyer
The kappa-deleting element. Germline and rearranged, duplicated and dispersed forms.
The Journal of experimental medicine 1988;167(2):488-501.
1988: Stanley J Korsmeyer
B-lymphoid neoplasms: immunoglobulin genes as molecular determinants of clonality, lineage, differentiation, and translocation.
Advances in internal medicine 1988;33():1-15.
1988: Stanley J Korsmeyer; RD Hockett; E A McGuire; G Nunez
Human delta T cell receptor: rearrangement, deletion, and translocation.
Princess Takamatsu symposia 1988;19():137-45.
1988: M Seto; U Jaeger; RD Hockett; W Graninger; S Bennett; P Goldman; Stanley J Korsmeyer
Alternative promoters and exons, somatic mutation and deregulation of the Bcl-2-Ig fusion gene in lymphoma.
The EMBO journal 1988;7(1):123-31.
1987: Jean-Pierre De Villartay; D Lewis; RD Hockett; Thomas Waldmann; Stanley J Korsmeyer; D I Cohen
Deletional rearrangement in the human T-cell receptor alpha-chain locus.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(23):8608-12.
1987: E Lipford; J J Wright; W Urba; J Whang-Peng; Ilan R Kirsch; Mark Raffeld; J Cossman; Dan Longo; A Bakhshi; Stanley J Korsmeyer
Refinement of lymphoma cytogenetics by the chromosome 18q21 major breakpoint region.
Blood 1987;70(6):1816-23.
1987: W B Graninger; M Seto; B Boutain; P Goldman; Stanley J Korsmeyer
Expression of Bcl-2 and Bcl-2-Ig fusion transcripts in normal and neoplastic cells.
The Journal of clinical investigation 1987;80(5):1512-5.
1987: Mark Raffeld; J J Wright; E Lipford; J Cossman; Dan Longo; A Bakhshi; Stanley J Korsmeyer
Clonal evolution of t(14;18) follicular lymphomas demonstrated by immunoglobulin genes and the 18q21 major breakpoint region.
Cancer research 1987;47(10):2537-42.
1987: J J Wright; David G Poplack; A Bakhshi; G Reaman; D Cole; J P Jensen; Stanley J Korsmeyer
Gene rearrangements as markers of clonal variation and minimal residual disease in acute lymphoblastic leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1987;5(5):735-41.
1987: A Bakhshi; J J Wright; W Graninger; M Seto; J Owens; J Cossman; J P Jensen; P Goldman; Stanley J Korsmeyer
Mechanism of the t(14;18) chromosomal translocation: structural analysis of both derivative 14 and 18 reciprocal partners.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(8):2396-400.
1986: A Bakhshi; P Guglielmi; J E Coligan; F Gamza; Thomas Waldmann; Stanley J Korsmeyer
A pre-translational defect in a case of human mu heavy chain disease.
Molecular immunology 1986;23(7):725-32.
1986: A Bakhshi; P Guglielmi; U Siebenlist; J V Ravetch; J P Jensen; Stanley J Korsmeyer
A DNA insertion/deletion necessitates an aberrant RNA splice accounting for a mu heavy chain disease protein.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(8):2689-93.
1985: K A Siminovitch; A Bakhshi; P Goldman; Stanley J Korsmeyer
A uniform deleting element mediates the loss of kappa genes in human B cells.
Nature 1985;316(6025):260-2.
1985: A Bakhshi; J P Jensen; P Goldman; J J Wright; O W McBride; A L Epstein; Stanley J Korsmeyer
Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around JH on chromosome 14 and near a transcriptional unit on 18.
Cell 1985;41(3):899-906.
1985: Thomas Waldmann; Stanley J Korsmeyer; A Bakhshi; A Arnold; Ilan R Kirsch
NIH conference. Molecular genetic analysis of human lymphoid neoplasms. Immunoglobulin genes and the c-myc oncogene.
Annals of internal medicine 1985;102(4):497-510.
1984: Stanley J Korsmeyer; A Bakhshi; A Arnold; K A Siminovitch; Thomas Waldmann
Human B-cell precursor leukemias.
Survey and synthesis of pathology research 1984;3(6):510-9.
1983: A Bakhshi; J Minowada; A Arnold; J Cossman; J P Jensen; J Whang-Peng; Thomas Waldmann; Stanley J Korsmeyer
Lymphoid blast crises of chronic myelogenous leukemia represent stages in the development of B-cell precursors.
The New England journal of medicine 1983;309(14):826-31.
1983: Stanley J Korsmeyer; Warner Greene; J Cossman; S M Hsu; J P Jensen; L M Neckers; S L Marshall; A Bakhshi; J M Depper; Warren J Leonard; E S Jaffe; Thomas Waldmann
Rearrangement and expression of immunoglobulin genes and expression of Tac antigen in hairy cell leukemia.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(14):4522-6.
1983: Stanley J Korsmeyer; A Arnold; A Bakhshi; J V Ravetch; U Siebenlist; P A Hieter; S O Sharrow; T W LeBien; J H Kersey; David G Poplack; P Leder; Thomas Waldmann
Immunoglobulin gene rearrangement and cell surface antigen expression in acute lymphocytic leukemias of T cell and B cell precursor origins.
The Journal of clinical investigation 1983;71(2):301-13.