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Kenji Kosaka

Research Profile

Disorders

Anatomy

Physiology

Genes & Molecular Sequences

Single Nucleotide Polymorphism

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Reverse Transcriptase Polymerase Chain Reaction

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Japan

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Publications

TOP 3
Yoshihiko Horimoto; Eiichi Katada; Akihiro Kojima; Kenji Kosaka; Mitsuhiro Matsumoto; Kazuya Nokura; Hiroko Yamamoto; Takayuki Yamamoto; Mari Yoshida; Hiroyuki Yuasa; Hiroyasu Akatsu; Yoshio Hashizume; Shigehisa Mitake
Longitudinal study on MRI intensity changes of Machado-Joseph disease: correlation between MRI findings and neuropathological changes.
Nuripa Jenishbekovna Aidaralieva; Kouzin Kamino; Ryo Kimura; Mitsuko Yamamoto; Takeshi Morihara; Hiroaki Kazui; Ryota Hashimoto; Toshihisa Tanaka; Takashi Kudo; Tomoyuki Kida; Jun-Ichiro Okuda; Takeshi Uema; Hidehisa Yamagata; Tetsuro Miki; Hiroyasu Akatsu; Kenji Kosaka; Masatoshi Takeda
Dynamin 2 gene is a novel susceptibility gene for late-onset Alzheimer disease in non-APOE-epsilon4 carriers.
Kun Zou; Haruyasu Yamaguchi; Hiroyasu Akatsu; Takaaki Sakamoto; Mihee Ko; Kazushige Mizoguchi; Jian-Sheng Gong; Wenxin Yu; Takayuki Yamamoto; Kenji Kosaka; Katsuhiko Yanagisawa; Makoto Michikawa
Angiotensin-converting enzyme converts amyloid beta-protein 1-42 (Abeta(1-42)) to Abeta(1-40), and its inhibition enhances brain Abeta deposition.

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All Publications

2011: Yoshihiko Horimoto; Eiichi Katada; Akihiro Kojima; Kenji Kosaka; Mitsuhiro Matsumoto; Kazuya Nokura; Hiroko Yamamoto; Takayuki Yamamoto; Mari Yoshida; Hiroyuki Yuasa; Hiroyasu Akatsu; Yoshio Hashizume; Shigehisa Mitake
Longitudinal study on MRI intensity changes of Machado-Joseph disease: correlation between MRI findings and neuropathological changes.
Journal of neurology 2011;258(9):1657-64.
2008: Nuripa Jenishbekovna Aidaralieva; Kouzin Kamino; Ryo Kimura; Mitsuko Yamamoto; Takeshi Morihara; Hiroaki Kazui; Ryota Hashimoto; Toshihisa Tanaka; Takashi Kudo; Tomoyuki Kida; Jun-Ichiro Okuda; Takeshi Uema; Hidehisa Yamagata; Tetsuro Miki; Hiroyasu Akatsu; Kenji Kosaka; Masatoshi Takeda
Dynamin 2 gene is a novel susceptibility gene for late-onset Alzheimer disease in non-APOE-epsilon4 carriers.
Journal of human genetics 2008;53(4):296-302.
2007: Kun Zou; Haruyasu Yamaguchi; Hiroyasu Akatsu; Takaaki Sakamoto; Mihee Ko; Kazushige Mizoguchi; Jian-Sheng Gong; Wenxin Yu; Takayuki Yamamoto; Kenji Kosaka; Katsuhiko Yanagisawa; Makoto Michikawa
Angiotensin-converting enzyme converts amyloid beta-protein 1-42 (Abeta(1-42)) to Abeta(1-40), and its inhibition enhances brain Abeta deposition.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(32):8628-35.
2007: Ryo Kimura; Kouzin Kamino; Mitsuko Yamamoto; Aidaralieva Nuripa; Tomoyuki Kida; Hiroaki Kazui; Ryota Hashimoto; Toshihisa Tanaka; Takashi Kudo; Hidehisa Yamagata; Yasuharu Tabara; Tetsuro Miki; Hiroyasu Akatsu; Kenji Kosaka; Eishi Funakoshi; Kouhei Nishitomi; Gaku Sakaguchi; Akira Kato; Hideyuki Hattori; Takeshi Uema; Masatoshi Takeda
The DYRK1A gene, encoded in chromosome 21 Down syndrome critical region, bridges between beta-amyloid production and tau phosphorylation in Alzheimer disease.
Human molecular genetics 2007;16(1):15-23.
2006: T Yokota; M Mishra; Hiroyasu Akatsu; Y Tani; T Miyauchi; Takayuki Yamamoto; Kenji Kosaka; Yasuo Nagai; Tohru Sawada; Klaus Heese
Brain site-specific gene expression analysis in Alzheimer's disease patients.
European journal of clinical investigation 2006;36(11):820-30.
2006: Kazuki Satoh; Mitsumi Hata; Seiji Takahara; Hidetoshi Tsuzaki; Hiroshi Yokota; Hiroyasu Akatsu; Takayuki Yamamoto; Kenji Kosaka; Tatsuo Yamada
A novel membrane protein, encoded by the gene covering KIAA0233, is transcriptionally induced in senile plaque-associated astrocytes.
Brain research 2006;1108(1):19-27.
2006: M Axel Wollmer; Elisabeth Kapaki; Martin Hersberger; Jörg Muntwyler; Fabienne Brunner; Magdalini Tsolaki; Hiroyasu Akatsu; Kenji Kosaka; Makoto Michikawa; Dimitra Molyva; George P Paraskevas; Dieter Lütjohann; Arnold von Eckardstein; Christoph Hock; Roger M Nitsch; Andreas Papassotiropoulos
Ethnicity-dependent genetic association of ABCA2 with sporadic Alzheimer's disease.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2006;141B(5):534-6.
2006: Noriaki Mitsuda; Hidehisa Yamagata; Wangtao Zhong; Mamoru Aoto; Hiroyasu Akatsu; Natsuko Uekawa; Kouzin Kamino; Keiko Taguchi; Takayuki Yamamoto; Mitsuo Maruyama; Kenji Kosaka; Masatoshi Takeda; Ikuko Kondo; Tetsuro Miki
A novel alternative splice variant of nicastrin and its implication in Alzheimer disease.
Life sciences 2006;78(21):2444-8.
2006: Hiroyasu Akatsu; Hidehisa Yamagata; Jun Kawamata; Kouzin Kamino; Masatoshi Takeda; Takayuki Yamamoto; Tetsuro Miki; Ikuo Tooyama; Shun Shimohama; Kenji Kosaka
Variations in the BDNF gene in autopsy-confirmed Alzheimer's disease and dementia with Lewy bodies in Japan.
Dementia and geriatric cognitive disorders 2006;22(3):216-22.
2005: Ian G McKeith; dennis dickson; J Lowe; M Emre; John T O'Brien; H Feldman; Jeffrey L Cummings; J E Duda; Carol F Lippa; Elaine K Perry; Dag Aarsland; Heii Arai; Clive G Ballard; Bradley Boeve; David J Burn; D Costa; T Del Ser; Bruno Dubois; Douglas Galasko; S Gauthier; Christopher G Goetz; E Gomez-Tortosa; G Halliday; Lawrence A Hansen; John Hardy; Takeshi Iwatsubo; Rajesh N. Kalaria; Daniel Kaufer; R A Kenny; Amos D Korczyn; Kenji Kosaka; Virginia M-Y Lee; Andrew J Lees; I Litvan; E Londos; Oscar L Lopez; Satoshi Minoshima; Yoshikuni Mizuno; J A Molina; E B Mukaetova-Ladinska; Florence Pasquier; Robert H Perry; J B Schulz; John Q Trojanowski; Masahito Yamada
Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium.
Neurology 2005;65(12):1863-72.
2005: Wangtao Zhong; Hidehisa Yamagata; Keiko Taguchi; Hiroyasu Akatsu; Kouzin Kamino; Takayuki Yamamoto; Kenji Kosaka; Masatoshi Takeda; Ikuko Kondo; Tetsuro Miki
Lymphocyte-specific protein tyrosine kinase is a novel risk gene for Alzheimer disease.
Journal of the neurological sciences 2005;238(1-2):53-7.
2005: Kazuki Satoh; Mitsumi Hata; Tomoko Shimizu; Hiroshi Yokota; Hiroyasu Akatsu; Takayuki Yamamoto; Kenji Kosaka; Tatsuo Yamada
Lib, transcriptionally induced in senile plaque-associated astrocytes, promotes glial migration through extracellular matrix.
Biochemical and biophysical research communications 2005;335(2):631-6.
2005: Keiko Taguchi; Hidehisa Yamagata; Wangtao Zhong; Kouzin Kamino; Hiroyasu Akatsu; Ryuji Hata; Takayuki Yamamoto; Kenji Kosaka; Masatoshi Takeda; Ikuko Kondo; Tetsuro Miki
Identification of hippocampus-related candidate genes for Alzheimer's disease.
Annals of neurology 2005;57(4):585-8.
2004: Hiroyasu Akatsu; Hidehisa Yamagata; Yusen Chen; Tetsuro Miki; Kouzin Kamino; Masatoshi Takeda; William Campbell; Ikuko Kondo; Kenji Kosaka; Takayuki Yamamoto; Hidechika Okada
TAFI polymorphisms at amino acids 147 and 325 are not risk factors for cerebral infarction.
British journal of haematology 2004;127(4):440-7.
2004: Hidehisa Yamagata; Yusen Chen; Hiroyasu Akatsu; Kouzin Kamino; Jin-ichi Ito; Shinji Yokoyama; Takayuki Yamamoto; Kenji Kosaka; Tetsuro Miki; Ikuko Kondo
Promoter polymorphism in fibroblast growth factor 1 gene increases risk of definite Alzheimer's disease.
Biochemical and biophysical research communications 2004;321(2):320-3.
2004: Kenji Kosaka
[Differential diagnosis of Alzheimer-type dementia and dementia with Lewy bodies].
Nihon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 4():159-63.
2004: Klaus Heese; T Yamada; Hiroyasu Akatsu; Takayuki Yamamoto; Kenji Kosaka; Yasuo Nagai; Tohru Sawada
Characterizing the new transcription regulator protein p60TRP.
Journal of cellular biochemistry 2004;91(5):1030-42.
2004: Klaus Heese; Masako Fujita; Hiroyasu Akatsu; Takayuki Yamamoto; Kenji Kosaka; Yasuo Nagai; Tohru Sawada
The splicing regulatory protein p18SRP is down-regulated in Alzheimer's disease brain.
Journal of molecular neuroscience : MN 2004;24(2):269-76.
2003: Yoshihiko Horimoto; Mitsuhiro Matsumoto; Hideka Nakazawa; Hiroyuki Yuasa; Manabu Morishita; Hiroyasu Akatsu; Hiroyuki Ikari; Takayuki Yamamoto; Kenji Kosaka
Cognitive conditions of pathologically confirmed dementia with Lewy bodies and Parkinson's disease with dementia.
Journal of the neurological sciences 2003;216(1):105-8.
2003: Yoshihiko Horimoto; Mitsuhiro Matsumoto; Hiroyasu Akatsu; Hiroyuki Ikari; Kiyohide Kojima; Takayuki Yamamoto; Yasushi Otsuka; Kosei Ojika; Ryuzo Ueda; Kenji Kosaka
Autonomic dysfunctions in dementia with Lewy bodies.
Journal of neurology 2003;250(5):530-3.
2002: Hiroyasu Akatsu; Mitsuo Takahashi; Noriyuki Matsukawa; Yasushige Ishikawa; Naoki Kondo; Tomoo Sato; Hideka Nakazawa; Tatsuo Yamada; Hidechika Okada; Takayuki Yamamoto; Kenji Kosaka
Subtype analysis of neuropathologically diagnosed patients in a Japanese geriatric hospital.
Journal of the neurological sciences 2002;196(1-2):63-9.
2002: Klaus Heese; Takahiro Nakayama; Ryuji Hata; Makoto Masumura; Hiroyasu Akatsu; Feng Li; Yasuo Nagai; Takayuki Yamamoto; Kenji Kosaka; Takahiro Suemoto; Tohru Sawada
Characterizing CGI-94 (comparative gene identification-94) which is down-regulated in the hippocampus of early stage Alzheimer's disease brain.
The European journal of neuroscience 2002;15(1):79-86.
2001: Ryuji Hata; Makoto Masumura; Hiroyasu Akatsu; F Li; H Fujita; Yasuo Nagai; Takayuki Yamamoto; H Okada; Kenji Kosaka; Masahiro Sakanaka; Tohru Sawada
Up-regulation of calcineurin Abeta mRNA in the Alzheimer's disease brain: assessment by cDNA microarray.
Biochemical and biophysical research communications 2001;284(2):310-6.
1988: N Iwamoto; Kenji Kosaka
[Recent topics on Alzheimer's disease. Immunological study of Alzheimer's disease].
Nihon rinsho. Japanese journal of clinical medicine 1988;46(7):1611-5.