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Steffen Koschmieder

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Elisabeth Bolton-Gillespie; Sylwia Flis; Tessa L Holyoake; Grazyna Hoser; Linda Kerstiens; Hans-Ulrich Klein; Mateusz Koptyra; Steffen Koschmieder; Thoralf Lange; Jacqueline Maier; Hardik Modi; Martin C Müller; Margaret Nieborowska-Skorska; Mirle Schemionek; Ilona Seferynska; Ravi Bhatia; Tomasz Stoklosa; Tomasz Skorski
Genomic instability may originate from imatinib-refractory chronic myeloid leukemia stem cells.
Gunhild Keller-von Amsberg; Steffen Koschmieder
Profile of bosutinib and its clinical potential in the treatment of chronic myeloid leukemia.
Gabriela B Thoennissen; Nils Thoennissen; Fleur Fritz; Andreas Hilbig; Andrea Kerkhoff; Steffen Koschmieder; Martin Kropff; Utz Krug; Rüdiger Liersch; Rolf M Mesters; Carsten Müller-Tidow; Wolfgang E Berdel
POEMS syndrome treated with melphalan high-dose therapy and autologous blood stem cell transplantation: a single-institution experience.

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2013: Elisabeth Bolton-Gillespie; Sylwia Flis; Tessa L Holyoake; Grazyna Hoser; Linda Kerstiens; Hans-Ulrich Klein; Mateusz Koptyra; Steffen Koschmieder; Thoralf Lange; Jacqueline Maier; Hardik Modi; Martin C Müller; Margaret Nieborowska-Skorska; Mirle Schemionek; Ilona Seferynska; Ravi Bhatia; Tomasz Stoklosa; Tomasz Skorski
Genomic instability may originate from imatinib-refractory chronic myeloid leukemia stem cells.
Blood 2013;121(20):4175-83.
2013: Gunhild Keller-von Amsberg; Steffen Koschmieder
Profile of bosutinib and its clinical potential in the treatment of chronic myeloid leukemia.
OncoTargets and therapy 2013;6():99-106.
2012: Gabriela B Thoennissen; Nils Thoennissen; Fleur Fritz; Andreas Hilbig; Andrea Kerkhoff; Steffen Koschmieder; Martin Kropff; Utz Krug; Rüdiger Liersch; Rolf M Mesters; Carsten Müller-Tidow; Wolfgang E Berdel
POEMS syndrome treated with melphalan high-dose therapy and autologous blood stem cell transplantation: a single-institution experience.
Annals of hematology 2012;91(9):1419-25.
2012: Steffen Koschmieder; Adriane Koppelle; Hans Seifert
Ruxolitinib for myelofibrosis.
The New England journal of medicine 2012;366(21):2031-2; author reply 2032-4.
2012: M Schemionek; Tilmann Spieker; A Trumpp; Carsten Müller-Tidow; Wolfgang E Berdel; C Elling; Marieke A G Essers; L Kerstiens; Steffen Koschmieder
Leukemic spleen cells are more potent than bone marrow-derived cells in a transgenic mouse model of CML.
Leukemia 2012;26(5):1030-7.
2012: U Brunnberg; T Büchner; U Dührsen; H A Dürk; Gerhard Ehninger; T Kessler; M Kosch; Steffen Koschmieder; U Krug; Rolf M Mesters; M Mohr; C Müller-Tidow; R Noppeney; Maria Cristina Sauerland; C Schulz; H Serve; Wolfgang E Berdel
Induction therapy of AML with ara-C plus daunorubicin versus ara-C plus gemtuzumab ozogamicin: a randomized phase II trial in elderly patients.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2012;23(4):990-6.
2012: Shuchi Agrawal-Singh; Nicole Bäumer; Anke Becker; Wolfgang E Berdel; Thomas Büchner; Martin Dugas; Gerhard Ehninger; Klaus Hansen; Antje Hascher; Fabienne Isken; Hans-Ulrich Klein; Gabriele Koehler; Steffen Koschmieder; Utz Krug; Michael McClelland; Peter Schlenke; Hubert Serve; Shailendra Vikram Singh; Christian Thiede; Nils Thoennissen; Yipeng Wang; Dae-Yeul Yu; Konstantin Agelopoulos; Carsten Müller-Tidow
Genome-wide analysis of histone H3 acetylation patterns in AML identifies PRDX2 as an epigenetically silenced tumor suppressor gene.
Blood 2012;119(10):2346-57.
2012: C I-U Chen; J Gerss; Heribert Juergens; L Kerstiens; Steffen Koschmieder; P P Lee; H T Maecker; Sibylle Pscherer; Bianca Altvater; Wolfgang E Berdel; M Schemionek; Claudia Rossig
NK cells are dysfunctional in human chronic myelogenous leukemia before and on imatinib treatment and in BCR-ABL-positive mice.
Leukemia 2012;26(3):465-74.
2012: Ashley Hamilton; G Vignir Helgason; Elaine K Allan; Ravi Bhatia; Valerie G Brunton; Steffen Koschmieder; Carsten Müller-Tidow; Svetlana Myssina; Franck E Nicolini; Mirle Schemionek; Bin Zhang; Tessa L Holyoake
Chronic myeloid leukemia stem cells are not dependent on Bcr-Abl kinase activity for their survival.
Blood 2012;119(6):1501-10.
2012: Utz Krug; Wolfgang E Berdel; Christian Brandts; Thomas Büchner; Gesine Bug; Ulrich Dührsen; Gerhard Ehninger; Joachim Gerss; Anja Koschmieder; Steffen Koschmieder; Richard Noppeney; Christoph Röllig; Markus Schaich; Daniela Schwammbach; Hubert Serve; Björn Steffen; Matthias Stelljes; Christian Thiede; Nicola Tidow; Carsten Müller-Tidow
Feasibility of azacitidine added to standard chemotherapy in older patients with acute myeloid leukemia--a randomised SAL pilot study.
PloS one 2012;7(12):e52695.
2012: Etmar Bulk; Antje Hascher; Ludger Hillejan; Steffen Koschmieder; Utz Krug; Alessandro Marra; Albrecht Schwab; Bernd Timmermann; Karsten Wiebe; Rainer Wiewrodt; Jun Yu; Wolfgang E Berdel; Carsten Müller-Tidow
Mutations of the EPHB6 receptor tyrosine kinase induce a pro-metastatic phenotype in non-small cell lung cancer.
PloS one 2012;7(12):e44591.
2012: Daniel B Lipka; Junia V Melo; Carsten Müller-Tidow; Mirle Schemionek; Tina Schnöder; Marie-Christine Wagner; Marek Dziadosz; Florian Heidel; Thomas Kindler; Steffen Koschmieder; Thomas Fischer
Intracellular retention of ABL kinase inhibitors determines commitment to apoptosis in CML cells.
PloS one 2012;7(7):e40853.
2012: Martin Schäfer; Torsten Wüstefeld; Lars Zender; Martin Dugas; Christian Elling; Hans-Ulrich Klein; Steffen Koschmieder; Otgonzul Lkhagvasuren; Carsten Müller-Tidow; Katja Ickstadt
Integrative analyses for omics data: a Bayesian mixture model to assess the concordance of ChIP-chip and ChIP-seq measurements.
Journal of toxicology and environmental health. Part A 2012;75(8-10):461-70.
2011: Lars Henning Schmidt; Tilmann Spieker; Karsten Wiebe; Rainer Wiewrodt; Danielle Wittmer; Sonja Schäffers; Wolfgang E Berdel; Etmar Bulk; Antje Hascher; Ludger Hillejan; Julia Humberg; Dominik Jungen; Steffen Koschmieder; Alessandro Marra; Carsten Muller-Tidow
The long noncoding MALAT-1 RNA indicates a poor prognosis in non-small cell lung cancer and induces migration and tumor growth.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2011;6(12):1984-92.
2011: Michele Pohlen; Iris Appelmann; Hans U Gerth; Torsten Kessler; Steffen Koschmieder; Rüdiger Liersch; Rolf M Mesters; Carsten Müller-Tidow; Wolfgang E Berdel
Efficacy and toxicity of a rituximab and methotrexate based regimen (GMALL B-ALL/NHL 2002 protocol) in Burkitt's and primary mediastinal large B-cell lymphoma.
American journal of hematology 2011;86(12):E61-4.
2011: Elena Levantini; Yutaka Okuno; Hanna S Radomska; Nicola K Wilson; Dong-Er Zhang; Junyan Zhang; Pu Zhang; Meritxell Alberich-Jorda; Giovanni Amabile; Daniela S Basseres; Constanze Bonifer; Alexander K Ebralidze; David A Gonzalez; Bertie Gottgens; Christopher J Hetherington; Gang Huang; Steffen Koschmieder; Sanghoon Lee; Daniel G Tenen
RUNX1 regulates the CD34 gene in haematopoietic stem cells by mediating interactions with a distal regulatory element.
The EMBO journal 2011;30(19):4059-70.
2011: Aaron D Schimmer; Karen Seiter; Martin S Tallman; Sonja Martin; Richard Noppeney; Gautham Borthakur; Pierre Desjardins; Walter Fiedler; Arthur Frankel; Aristoteles Giagounidis; Mathias Hänel; Wolfgang Herr; Heinz-August Horst; Christine Jacob; Jacques Jolivet; Jeannine Kassis; Steffen Koschmieder
Addition of AEG35156 XIAP antisense oligonucleotide in reinduction chemotherapy does not improve remission rates in patients with primary refractory acute myeloid leukemia in a randomized phase II study.
Clinical lymphoma, myeloma & leukemia 2011;11(5):433-8.
2011: Andreas N Schüring; Johannes Wessling; Verena Nordhoff; Nicole Schulte; Wolfgang E Berdel; Ludwig Kiesel; Sabine Kliesch; Steffen Koschmieder
Spontaneous conception and live birth after gonadotoxic chemotherapy for an aggressive bilateral ovarian Burkitt's lymphoma.
European journal of obstetrics, gynecology, and reproductive biology 2011;158(2):362-4.
2011: Nicole Bäumer; Sebastian Bäumer; Wolfgang E Berdel; Sven Diederichs; Gabriele Köhler; Steffen Koschmieder; Lisa Lohmeyer; Hubert Serve; Boris V Skryabin; Lara Tickenbrock; Petra Tschanter; Feng Zhang; Shuchi Agrawal-Singh; Carsten Müller-Tidow
Inhibitor of cyclin-dependent kinase (CDK) interacting with cyclin A1 (INCA1) regulates proliferation and is repressed by oncogenic signaling.
The Journal of biological chemistry 2011;286(32):28210-22.
2011: Matthias Stelljes; Carsten Müller-Tidow; Claudia Rossig; Richard F Schlenk; Gerda Silling; Wolfgang E Berdel; Andrea Corbacioglu; Hartmut Döhner; Konstanze Döhner; Karoline Ehlert; M C Frühwald; H Juergens; Joachim Kienast; Steffen Koschmieder
Allogeneic stem cell transplant to eliminate germline mutations in the gene for CCAAT-enhancer-binding protein α from hematopoietic cells in a family with AML.
Leukemia 2011;25(7):1209-10.
2011: Lara Tickenbrock; Hans-Ulrich Klein; Cristina Trento; Antje Hascher; Stefanie Göllner; Nicole Bäumer; Robert Kuss; Shuchi Agrawal; Gesine Bug; Hubert Serve; Christian Thiede; Gerhard Ehninger; Udo Zur Stadt; Michael McClelland; Yipeng Wang; Anke Becker; Steffen Koschmieder; Wolfgang E Berdel; Martin Dugas; Carsten Müller-Tidow
Increased HDAC1 deposition at hematopoietic promoters in AML and its association with patient survival.
Leukemia research 2011;35(5):620-5.
2011: Björn Steffen; Markus Knop; Ulla Bergholz; Olesya Vakhrusheva; Miriam Rode; Gabriele Köhler; Marcel-Philipp Henrichs; Etmar Bulk; Sina Hehn; Martin Stehling; Martin Dugas; Nicole Bäumer; Petra Tschanter; Christian Brandts; Steffen Koschmieder; Wolfgang E Berdel; Hubert Serve; Carol Stocking; Carsten Müller-Tidow
AML1/ETO induces self-renewal in hematopoietic progenitor cells via the Groucho-related amino-terminal AES protein.
Blood 2011;117(16):4328-37.
2011: Richard A Van Etten; Steffen Koschmieder; Francois Delhommeau; Danilo Perrotti; Tessa Holyoake; Animesh Pardanani; Ruben Mesa; Tony Green; Amr R Ibrahim; Tariq Mughal; Robert Peter Gale; John Goldman
The Ph-positive and Ph-negative myeloproliferative neoplasms: some topical pre-clinical and clinical issues.
Haematologica 2011;96(4):590-601.
2011: Christian Elling; Philipp Erben; Christoph Walz; Marie Frickenhaus; Mirle Schemionek; Martin Stehling; Hubert Serve; Nicholas C P Cross; Andreas Hochhaus; Wolf-Karsten Hofmann; Wolfgang E Berdel; Carsten Müller-Tidow; Andreas Reiter; Steffen Koschmieder
Novel imatinib-sensitive PDGFRA-activating point mutations in hypereosinophilic syndrome induce growth factor independence and leukemia-like disease.
Blood 2011;117(10):2935-43.
2011: Steffen Koschmieder; Mirle Schemionek
Mouse models as tools to understand and study BCR-ABL1 diseases.
American journal of blood research 2011;1(1):65-75.
2010: Utz Krug; Christoph Röllig; Anja Koschmieder; Achim Heinecke; Maria Cristina Sauerland; Markus Schaich; Christian Thiede; Michael Kramer; Jan Braess; Karsten Spiekermann; Torsten Haferlach; Claudia Haferlach; Steffen Koschmieder; Christian Rohde; Hubert Serve; Bernhard Wörmann; Wolfgang Hiddemann; Gerhard Ehninger; Wolfgang E Berdel; Thomas Büchner; Carsten Müller-Tidow
Complete remission and early death after intensive chemotherapy in patients aged 60 years or older with acute myeloid leukaemia: a web-based application for prediction of outcomes.
Lancet 2010;376(9757):2000-8.
2010: Carsten Müller-Tidow; Hans-Ulrich Klein; Antje Hascher; Fabienne Isken; Lara Tickenbrock; Nils Thoennissen; Shuchi Agrawal-Singh; Petra Tschanter; Christine Disselhoff; Yipeng Wang; Anke Becker; Christian Thiede; Gerhard Ehninger; Udo zur Stadt; Steffen Koschmieder; Matthias Seidl; Frank U Müller; Wilhelm Schmitz; Peter Schlenke; Michael McClelland; Wolfgang E Berdel; Martin Dugas; Hubert Serve
Profiling of histone H3 lysine 9 trimethylation levels predicts transcription factor activity and survival in acute myeloid leukemia.
Blood 2010;116(18):3564-71.
2010: Claudia Hömme; Utz Krug; N Tidow; Bernd Schulte; Gabriele Kühler; Hubert Serve; Horst Bürger; Wolfgang E Berdel; Martin Dugas; Achim Heinecke; Thomas Büchner; Steffen Koschmieder; Carsten Müller-Tidow
Low SMC1A protein expression predicts poor survival in acute myeloid leukemia.
Oncology reports 2010;24(1):47-56.
2010: Shuchi Agrawal-Singh; Steffen Koschmieder; Sandra Gelsing; Carol Stocking; Martin Stehling; Christian Thiede; Nils Thoennissen; Gabriele Köhler; Peter J M Valk; Ruud Delwel; Ken Mills; Nicole Bäumer; Lara Tickenbrock; Klaus Hansen; Wolfgang E Berdel; Carsten Müller-Tidow; Hubert Serve
Pim2 cooperates with PML-RARalpha to induce acute myeloid leukemia in a bone marrow transplantation model.
Blood 2010;115(22):4507-16.
2010: Cord Rehmsmeier; Torsten Kessler; Steffen Koschmieder; Matthias Ross; Matthias Weckesser; Johannes Wessling; Gabriele Koehler; Wolfgang E Berdel
Mixed response in interim positron emission tomography/computed tomography leads to detection of a gastrointestinal stromal tumor in a patient with mediastinal diffuse large B-cell lymphoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2010;28(14):e215-7.
2010: Jun Yu; Etmar Bulk; Ping Ji; Antje Hascher; Moying Tang; Ralf Metzger; Alessandro Marra; Hubert Serve; Wolfgang E Berdel; Rainer Wiewroth; Steffen Koschmieder; Carsten Müller-Tidow
The EPHB6 receptor tyrosine kinase is a metastasis suppressor that is frequently silenced by promoter DNA hypermethylation in non-small cell lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(8):2275-83.
2010: Michele Pohlen; Bülent Sargin; Stefan Zicholl; Guido Bisping; Carsten Müller-Tidow; Wolfgang E Berdel; Rolf Mesters; Steffen Koschmieder
Combination of romiplostim and rituximab: effective therapy of severe immune thrombocytopenia.
European journal of haematology 2010;84(4):362-4.
2009: Jun Yu; Etmar Bulk; Ping Ji; Antje Hascher; Steffen Koschmieder; Wolfgang E Berdel; Carsten Müller-Tidow
The kinase defective EPHB6 receptor tyrosine kinase activates MAP kinase signaling in lung adenocarcinoma.
International journal of oncology 2009;35(1):175-9.
2009: Svetlana Myssina; G Vignir Helgason; Alan Serrels; Heather G Jørgensen; Ravi Bhatia; Hardik Modi; Janet W Baird; joanne mountford; Ashley Hamilton; Mirle Schemionek; Steffen Koschmieder; Valerie G Brunton; Tessa L Holyoake
Combined BCR-ABL inhibition with lentiviral-delivered shRNA and dasatinib augments induction of apoptosis in Philadelphia-positive cells.
Experimental hematology 2009;37(2):206-14.
2009: Steffen Koschmieder; Balazs Halmos; Elena Levantini; Daniel G Tenen
Dysregulation of the C/EBPalpha differentiation pathway in human cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009;27(4):619-28.
2009: Jun Yu; Helena Müller; Sina Hehn; Steffen Koschmieder; Kai Schönig; Wolfgang E Berdel; Hubert Serve; Carsten Müller-Tidow
Construction and application of an inducible system for homogenous expression levels in bulk cell lines.
PloS one 2009;4(7):e6445.
2009: Etmar Bulk; Bülent Sargin; Utz Krug; Antje Hascher; Yu Jun; Markus Knop; Claus Kerkhoff; Volker Gerke; Ruediger Liersch; Rolf M Mesters; Marc Hotfilder; Alessandro Marra; Steffen Koschmieder; Martin Dugas; Wolfgang E Berdel; Hubert Serve; Carsten Müller-Tidow
S100A2 induces metastasis in non-small cell lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(1):22-9.
2008: Gang Huang; Pu Zhang; Hideyo Hirai; Shannon Elf; Xiaomei Yan; Zhao Chen; Steffen Koschmieder; Yutaka Okuno; Tajhal Dayaram; Joseph D Growney; Ramesh A Shivdasani; D Gary Gilliland; Nancy A Speck; Stephen D Nimer; Daniel G Tenen
PU.1 is a major downstream target of AML1 (RUNX1) in adult mouse hematopoiesis.
Nature genetics 2008;40(1):51-60.
2008: Shuchi Agrawal; Steffen Koschmieder; Nicole Bäumer; NG Pavankumar Reddy; Wolfgang E Berdel; Carsten Müller-Tidow; Hubert Serve
Pim2 complements Flt3 wild-type receptor in hematopoietic progenitor cell transformation.
Leukemia 2008;22(1):78-86.
2007: Steffen Koschmieder; Francesco D'Alò; Hanna S Radomska; Christine Schöneich; Ji Suk Chang; Marina Konopleva; Susumu Kobayashi; Elena Levantini; Nanjoo Suh; Annalisa Di Ruscio; Maria Teresa Voso; Julie C Watt; Ramasamy Santhanam; Bülent Sargin; Andrew Lamb; Michael Andreeff; Michael B. Sporn; Danilo Perrotti; Wolfgang E Berdel; Carsten Müller-Tidow; Hubert Serve; Daniel G Tenen
CDDO induces granulocytic differentiation of myeloid leukemic blasts through translational up-regulation of p42 CCAAT enhancer binding protein alpha.
Blood 2007;110(10):3695-705.
2007: Ulrich Steidl; Christian Steidl; Alexander Ebralidze; Bjoern Chapuy; Hye-Jung Han; Britta Will; Frank Rosenbauer; Annegret Becker; Katharina Wagner; Steffen Koschmieder; Susumu Kobayashi; Daniel B Costa; Thomas Schulz; Karen B O'Brien; Roel G W Verhaak; Ruud Delwel; Detlef Haase; Lorenz Trümper; Jürgen Krauter; Terumi Kohwi-Shigematsu; Frank Griesinger; Daniel G Tenen
A distal single nucleotide polymorphism alters long-range regulation of the PU.1 gene in acute myeloid leukemia.
The Journal of clinical investigation 2007;117(9):2611-20.
2007: Bülent Sargin; Chunaram Choudhary; Nicola Crosetto; Mirko H H Schmidt; Rebekka Grundler; Marion Rensinghoff; Christine Thiessen; Lara Tickenbrock; Joachim Schwäble; Christian Brandts; Benjamin August; Steffen Koschmieder; Srinivasa Rao Bandi; Justus Duyster; Wolfgang E Berdel; Carsten Müller-Tidow; Ivan Dikic; Hubert Serve
Flt3-dependent transformation by inactivating c-Cbl mutations in AML.
Blood 2007;110(3):1004-12.
2007: Shuchi Agrawal; Wolf-Karsten Hofmann; Nicola Tidow; Mathias Ehrich; Dirk van den Boom; Steffen Koschmieder; Wolfgang E Berdel; Hubert Serve; Carsten Müller-Tidow
The C/EBPdelta tumor suppressor is silenced by hypermethylation in acute myeloid leukemia.
Blood 2007;109(9):3895-905.
2007: Shuchi Agrawal; Matthias Unterberg; Steffen Koschmieder; Udo zur Stadt; Uta Brunnberg; Walter Verbeek; Thomas Büchner; Wolfgang E Berdel; Hubert Serve; Carsten Müller-Tidow
DNA methylation of tumor suppressor genes in clinical remission predicts the relapse risk in acute myeloid leukemia.
Cancer research 2007;67(3):1370-7.
2007: Steffen Koschmieder; Shuchi Agrawal; Hanna S Radomska; Claudia S Huettner; Daniel G Tenen; Oliver G Ottmann; Wolfgang E Berdel; Hubert Serve; Carsten Müller-Tidow
Decitabine and vitamin D3 differentially affect hematopoietic transcription factors to induce monocytic differentiation.
International journal of oncology 2007;30(2):349-55.
2006: Noriko Koyama; Steffen Koschmieder; Sandhya Tyagi; Ignacio Portero-Robles; Jörg Chromic; Silke Myloch; Heike Nürnberger; Tanja Rossmanith; Wolf-Karsten Hofmann; Dieter Hoelzer; Oliver G Ottmann
Inhibition of phosphotyrosine phosphatase 1B causes resistance in BCR-ABL-positive leukemia cells to the ABL kinase inhibitor STI571.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(7 Pt 1):2025-31.
2005: Frank Rosenbauer; Steffen Koschmieder; Ulrich Steidl; Daniel G Tenen
Effect of transcription-factor concentrations on leukemic stem cells.
Blood 2005;106(5):1519-24.
2005: Steffen Koschmieder; Frank Rosenbauer; Ulrich Steidl; Bronwyn M. Owens; Daniel G Tenen
Role of transcription factors C/EBPalpha and PU.1 in normal hematopoiesis and leukemia.
International journal of hematology 2005;81(5):368-77.
2005: Steffen Koschmieder; Berthold Göttgens; Pu Zhang; Junko Iwasaki-Arai; Koichi Akashi; Jeffery L Kutok; Tajhal Dayaram; Kristin Geary; Anthony R Green; Daniel G Tenen; Claudia S Huettner
Inducible chronic phase of myeloid leukemia with expansion of hematopoietic stem cells in a transgenic model of BCR-ABL leukemogenesis.
Blood 2005;105(1):324-34.
2003: Claudia S Huettner; Steffen Koschmieder; Hiromi Iwasaki; Junko Iwasaki-Arai; Hanna S Radomska; Koichi Akashi; Daniel G Tenen
Inducible expression of BCR/ABL using human CD34 regulatory elements results in a megakaryocytic myeloproliferative syndrome.
Blood 2003;102(9):3363-70.
2003: Steffen Koschmieder; Wolfgang Miesbach; Florian Fauth; Jörg Bojunga; Inge Scharrer; Hans-Reinhard Brodt
Combined plasmapheresis and immunosuppression as rescue treatment of a patient with catastrophic antiphospholipid syndrome occurring despite anticoagulation: a case report.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 2003;14(4):395-9.
2002: Katharina Schroeder; Steffen Koschmieder; Oliver G Ottmann; Dieter Hoelzer; Hansjörg Hauser; Peter P Mueller
Coordination of cell growth in cocultures by a genetic proliferation control system.
Biotechnology and bioengineering 2002;78(3):346-52.
2002: Noriko Koyama; Steffen Koschmieder; Sandhya Tyagi; Heike Nürnberger; Sandra Wagner; Ulrich Böcker; Dieter Hoelzer; Oliver Gerhard Ottmann; Uwe Kalina
Differential effects of histone deacetylase inhibitors on interleukin-18 gene expression in myeloid cells.
Biochemical and biophysical research communications 2002;292(4):937-43.
2002: Steffen Koschmieder; Florian Fauth; Susanne Kriener; Dieter Hoelzer; Gernot Seipelt
Effective treatment of simultaneous small cell lung cancer and B-cell lymphoma.
Leukemia & lymphoma 2002;43(3):645-7.
2002: Gernot Seipelt; Ulrich Germing; Steffen Koschmieder; Angelika Böhme; Carlo Aul; Dieter Hoelzer
Secondary acute myeloid leukaemia with monosomy 7 in identical adult twins.
British journal of haematology 2002;116(2):338-40.
2001: Steffen Koschmieder; Wolf-Karsten Hofmann; J Kunert; Sandra Wagner; K Ballas; Gernot Seipelt; Dieter Hoelzer; Oliver G Ottmann; Uwe Kalina
TGF beta-induced SMAD2 phosphorylation predicts inhibition of thymidine incorporation in CD34+ cells from healthy donors, but not from patients with AML after MDS.
Leukemia 2001;15(6):942-9.
2001: Uwe Kalina; Steffen Koschmieder; Wolf-Karsten Hofmann; Sandra Wagner; D Kauschat; Dieter Hoelzer; Oliver G Ottmann
Transforming growth factor-beta1 interferes with thrombopoietin-induced signal transduction in megakaryoblastic and erythroleukemic cells.
Experimental hematology 2001;29(5):602-8.
2001: Gernot Seipelt; Angelika Böhme; Steffen Koschmieder; Dieter Hoelzer
Effective treatment with rituximab in a patient with refractory prolymphocytoid transformed B-chronic lymphocytic leukemia and Evans syndrome.
Annals of hematology 2001;80(3):170-3.
2001: Steffen Koschmieder; Gesine Bug; B Schröder; Tanja Rossmanith; Wolf-Karsten Hofmann; Uwe Kalina; Dieter Hoelzer; Oliver G Ottmann
Murine M2-10B4 and SL/SL cell lines differentially affect the balance between CD34+ cell expansion and maturation.
International journal of hematology 2001;73(1):71-7.
2000: Uwe Kalina; Wolf-Karsten Hofmann; Steffen Koschmieder; Sandra Wagner; D Kauschat; Dieter Hoelzer; Oliver G Ottmann
Alteration of c-mpl-mediated signal transduction in CD34(+) cells from patients with myelodysplastic syndromes.
Experimental hematology 2000;28(10):1158-63.
2000: Uwe Kalina; D Kauschat; Noriko Koyama; H Nuernberger; K Ballas; Steffen Koschmieder; Gesine Bug; Wolf-Karsten Hofmann; Dieter Hoelzer; Oliver G Ottmann
IL-18 activates STAT3 in the natural killer cell line 92, augments cytotoxic activity, and mediates IFN-gamma production by the stress kinase p38 and by the extracellular regulated kinases p44erk-1 and p42erk-21.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(3):1307-13.
2000: Wolf-Karsten Hofmann; Uwe Kalina; Steffen Koschmieder; Gernot Seipelt; Dieter Hoelzer; Oliver G Ottmann
Defective megakaryocytic development in myelodysplastic syndromes.
Leukemia & lymphoma 2000;38(1-2):13-9.
2000: Wolf-Karsten Hofmann; Gernot Seipelt; Oliver G Ottmann; Uwe Kalina; Steffen Koschmieder; J Brücher; N Frickhofen; M Klausmann; Paris S Mitrou; Dieter Hoelzer
Effect of treatment with amifostine used as a single agent in patients with refractory anemia on clinical outcome and serum tumor necrosis factor alpha levels.
Annals of hematology 2000;79(5):255-8.