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Daniel Koshland

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TOP 3
Daniel E Koshland
Philosophy of science. The Cha-Cha-Cha Theory of Scientific Discovery.
Evette S Radisky; Justin M Lee; Chia-Jung Karen Lu; Daniel E Koshland
Insights into the serine protease mechanism from atomic resolution structures of trypsin reaction intermediates.
Evette S Radisky; Chia-Jung Karen Lu; Gene Kwan; Daniel E Koshland
Role of the intramolecular hydrogen bond network in the inhibitory power of chymotrypsin inhibitor 2.

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All Publications

2007: Daniel E Koshland
Philosophy of science. The Cha-Cha-Cha Theory of Scientific Discovery.
Science (New York, N.Y.) 2007;317(5839):761-2.
2006: Evette S Radisky; Justin M Lee; Chia-Jung Karen Lu; Daniel E Koshland
Insights into the serine protease mechanism from atomic resolution structures of trypsin reaction intermediates.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(18):6835-40.
2005: Evette S Radisky; Chia-Jung Karen Lu; Gene Kwan; Daniel E Koshland
Role of the intramolecular hydrogen bond network in the inhibitory power of chymotrypsin inhibitor 2.
Biochemistry 2005;44(18):6823-30.
2004: Daniel E Koshland
Crazy, but correct.
Nature 2004;432(7016):447.
2004: Evette S Radisky; Gene Kwan; Chia-Jung Karen Lu; Daniel E Koshland
Binding, proteolytic, and crystallographic analyses of mutations at the protease-inhibitor interface of the subtilisin BPN'/chymotrypsin inhibitor 2 complex.
Biochemistry 2004;43(43):13648-56.
2003: Evette S Radisky; David S King; Gene Kwan; Daniel E Koshland
The role of the protein core in the inhibitory power of the classic serine protease inhibitor, chymotrypsin inhibitor 2.
Biochemistry 2003;42(21):6484-92.
2003: Edward W Yu; Gerry McDermott; Helen I Zgurskaya; Hiroshi Nikaido; Daniel E Koshland
Structural basis of multiple drug-binding capacity of the AcrB multidrug efflux pump.
Science (New York, N.Y.) 2003;300(5621):976-80.
2002: Daniel E Koshland; Kambiz Hamadani
Proteomics and models for enzyme cooperativity.
The Journal of biological chemistry 2002;277(49):46841-4.
2002: Evette S Radisky; Daniel E Koshland
A clogged gutter mechanism for protease inhibitors.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(16):10316-21.
2002: Daniel E Koshland
The application and usefulness of the ratio k(cat)/K(M).
Bioorganic chemistry 2002;30(3):211-3.
2002: Daniel E Koshland
Special essay. The seven pillars of life.
Science (New York, N.Y.) 2002;295(5563):2215-6.
2002: Neil W Charter; Lara K Mahal; Daniel E Koshland; Carolyn R Bertozzi
Differential effects of unnatural sialic acids on the polysialylation of the neural cell adhesion molecule and neuronal behavior.
The Journal of biological chemistry 2002;277(11):9255-61.
2001: Lara K Mahal; Neil W Charter; K Angata; M Fukuda; Daniel E Koshland; Carolyn R Bertozzi
A small-molecule modulator of poly-alpha 2,8-sialic acid expression on cultured neurons and tumor cells.
Science (New York, N.Y.) 2001;294(5541):380-1.
2001: Edward W Yu; Daniel E Koshland
Propagating conformational changes over long (and short) distances in proteins.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(17):9517-20.
2001: Sharon A Doyle; Peter Beernink; Daniel E Koshland
Structural basis for a change in substrate specificity: crystal structure of S113E isocitrate dehydrogenase in a complex with isopropylmalate, Mg2+, and NADP.
Biochemistry 2001;40(14):4234-41.
2000: Sharon A Doyle; S Y Fung; Daniel E Koshland
Redesigning the substrate specificity of an enzyme: isocitrate dehydrogenase.
Biochemistry 2000;39(46):14348-55.
2000: Neil W Charter; Lara K Mahal; Daniel E Koshland; Carolyn R Bertozzi
Biosynthetic incorporation of unnatural sialic acids into polysialic acid on neural cells.
Glycobiology 2000;10(10):1049-56.
2000: Andrew D Mesecar; Daniel E Koshland
Sites of binding and orientation in a four-location model for protein stereospecificity.
IUBMB life 2000;49(5):457-66.
2000: Andrew D Mesecar; Daniel E Koshland
A new model for protein stereospecificity.
Nature 2000;403(6770):614-5.
1999: Constance J Jeffery; Daniel E Koshland
The Escherichia coli aspartate receptor: sequence specificity of a transmembrane helix studied by hydrophobic-biased random mutagenesis.
Protein engineering 1999;12(10):863-72.
1999: Karen M Ottemann; wenzhong xiao; YK Shin; Daniel E Koshland
A piston model for transmembrane signaling of the aspartate receptor.
Science (New York, N.Y.) 1999;285(5434):1751-4.
1998: H Le Moual; T Quang; Daniel E Koshland
Conformational changes in the cytoplasmic domain of the Escherichia coli aspartate receptor upon adaptive methylation.
Biochemistry 1998;37(42):14852-9.
1998: Barry L Stoddard; B E Cohen; M Brubaker; Andrew D Mesecar; Daniel E Koshland
Millisecond Laue structures of an enzyme-product complex using photocaged substrate analogs.
Nature structural biology 1998;5(10):891-7.
1998: Karen M Ottemann; TE Thorgeirsson; A F Kolodziej; YK Shin; Daniel E Koshland
Direct measurement of small ligand-induced conformational changes in the aspartate chemoreceptor using EPR.
Biochemistry 1998;37(20):7062-9.
1998: Daniel E Koshland
The era of pathway quantification.
Science (New York, N.Y.) 1998;280(5365):852-3.
1997: H Le Moual; T Quang; Daniel E Koshland
Methylation of the Escherichia coli chemotaxis receptors: intra- and interdimer mechanisms.
Biochemistry 1997;36(43):13441-8.
1997: Karen M Ottemann; Daniel E Koshland
Converting a transmembrane receptor to a soluble receptor: recognition domain to effector domain signaling after excision of the transmembrane domain.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(21):11201-4.
1997: X Chen; Daniel E Koshland
Probing the structure of the cytoplasmic domain of the aspartate receptor by targeted disulfide cross-linking.
Biochemistry 1997;36(39):11858-64.
1997: B E Cohen; Barry L Stoddard; Daniel E Koshland
Caged NADP and NAD. Synthesis and characterization of functionally distinct caged compounds.
Biochemistry 1997;36(29):9035-44.
1997: Andrew D Mesecar; Barry L Stoddard; Daniel E Koshland
Orbital steering in the catalytic power of enzymes: small structural changes with large catalytic consequences.
Science (New York, N.Y.) 1997;277(5323):202-6.
1996: Daniel E Koshland
The structural basis of negative cooperativity: receptors and enzymes.
Current opinion in structural biology 1996;6(6):757-61.
1996: A F Kolodziej; Thomas Tan; Daniel E Koshland
Producing positive, negative, and no cooperativity by mutations at a single residue located at the subunit interface in the aspartate receptor of Salmonella typhimurium.
Biochemistry 1996;35(47):14782-92.
1996: J I Yeh; H P Biemann; G G Privé; J Pandit; Daniel E Koshland; Sung-Huo S H Kim
High-resolution structures of the ligand binding domain of the wild-type bacterial aspartate receptor.
Journal of molecular biology 1996;262(2):186-201.
1996: H Le Moual; Daniel E Koshland
Molecular evolution of the C-terminal cytoplasmic domain of a superfamily of bacterial receptors involved in taxis.
Journal of molecular biology 1996;261(4):568-85.
1995: X Chen; Daniel E Koshland
The N-terminal cytoplasmic tail of the aspartate receptor is not essential in signal transduction of bacterial chemotaxis.
The Journal of biological chemistry 1995;270(41):24038-42.
1995: P T Martin; Daniel E Koshland
Neurosecretory habituation in PC12 cells: modulation during parallel habituation.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(11):5052-6.
1995: M J Shapiro; I Chakrabarti; Daniel E Koshland
Contributions made by individual methylation sites of the Escherichia coli aspartate receptor to chemotactic behavior.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(4):1053-6.
1995: M J Shapiro; D Panomitros; Daniel E Koshland
Interactions between the methylation sites of the Escherichia coli aspartate receptor mediated by the methyltransferase.
The Journal of biological chemistry 1995;270(2):751-5.
1995: T Zhang; Daniel E Koshland
Modeling substrate binding in Thermus thermophilus isopropylmalate dehydrogenase.
Protein science : a publication of the Protein Society 1995;4(1):84-92.
1994: L Cheever; Daniel E Koshland
Habituation of neurosecretory responses to extracellular ATP in PC12 cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1994;14(8):4831-8.
1994: M J Shapiro; Daniel E Koshland
Mutagenic studies of the interaction between the aspartate receptor and methyltransferase from Escherichia coli.
The Journal of biological chemistry 1994;269(15):11054-9.
1994: Constance J Jeffery; Daniel E Koshland
A single hydrophobic to hydrophobic substitution in the transmembrane domain impairs aspartate receptor function.
Biochemistry 1994;33(12):3457-63.
1994: H P Biemann; Daniel E Koshland
Aspartate receptors of Escherichia coli and Salmonella typhimurium bind ligand with negative and half-of-the-sites cooperativity.
Biochemistry 1994;33(3):629-34.
1993: Daniel E Koshland
The two-component pathway comes to eukaryotes.
Science (New York, N.Y.) 1993;262(5133):532.
1993: P T Martin; B T Chung; Daniel E Koshland
Regulation of neurosecretory habituation by cAMP. Role of adaptation of cAMP signals.
European journal of biochemistry / FEBS 1993;217(1):259-65.
1993: D L Milligan; Daniel E Koshland
Purification and characterization of the periplasmic domain of the aspartate chemoreceptor.
The Journal of biological chemistry 1993;268(27):19991-7.
1993: Barry L Stoddard; Daniel E Koshland
Structure of isocitrate dehydrogenase with alpha-ketoglutarate at 2.7-A resolution: conformational changes induced by decarboxylation of isocitrate.
Biochemistry 1993;32(36):9317-22.
1993: Barry L Stoddard; A Dean; Daniel E Koshland
Structure of isocitrate dehydrogenase with isocitrate, nicotinamide adenine dinucleotide phosphate, and calcium at 2.5-A resolution: a pseudo-Michaelis ternary complex.
Biochemistry 1993;32(36):9310-6.
1993: Constance J Jeffery; Daniel E Koshland
Vibrio cholerae hlyB is a member of the chemotaxis receptor gene family.
Protein science : a publication of the Protein Society 1993;2(9):1532-5.
1993: Daniel E Koshland
The joys and vicissitudes of protein science.
Protein science : a publication of the Protein Society 1993;2(8):1364-8.
1993: William G Scott; D L Milligan; M V Milburn; G G Privé; J Yeh; Daniel E Koshland; Sung-Huo S H Kim
Refined structures of the ligand-binding domain of the aspartate receptor from Salmonella typhimurium.
Journal of molecular biology 1993;232(2):555-73.
1993: J I Yeh; H P Biemann; J Pandit; Daniel E Koshland; Sung-Huo S H Kim
The three-dimensional structure of the ligand-binding domain of a wild-type bacterial chemotaxis receptor. Structural comparison to the cross-linked mutant forms and conformational changes upon ligand binding.
The Journal of biological chemistry 1993;268(13):9787-92.
1993: Constance J Jeffery; Daniel E Koshland
Three-dimensional structural model of the serine receptor ligand-binding domain.
Protein science : a publication of the Protein Society 1993;2(4):559-66.
1993: Barry L Stoddard; Daniel E Koshland
Molecular recognition analyzed by docking simulations: the aspartate receptor and isocitrate dehydrogenase from Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(4):1146-53.
1992: Barry L Stoddard; J D Bui; Daniel E Koshland
Structure and dynamics of transmembrane signaling by the Escherichia coli aspartate receptor.
Biochemistry 1992;31(48):11978-83.
1992: L Cheever; Daniel E Koshland
Retention of habituation in PC12 cells.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(21):10084-8.
1992: P T Martin; Daniel E Koshland
Regulation of neurosecretory habituation in PC12 cells: parallel pathways used by cAMP and calcium.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(21):10257-61.
1992: Barry L Stoddard; Daniel E Koshland
Prediction of the structure of a receptor-protein complex using a binary docking method.
Nature 1992;358(6389):774-6.
1992: David Avram Sanders; B L Gillece-Castro; Al L Burlingame; Daniel E Koshland
Phosphorylation site of NtrC, a protein phosphatase whose covalent intermediate activates transcription.
Journal of bacteriology 1992;174(15):5117-22.
1992: Berkley Lynch; Daniel E Koshland
The fifth Datta Lecture. Structural similarities between the aspartate receptor of bacterial chemotaxis and the trp repressor of E. coli. Implications for transmembrane signaling.
FEBS letters 1992;307(1):3-9.
1992: Barry L Stoddard; H P Biemann; Daniel E Koshland
Receptors and transmembrane signaling.
Cold Spring Harbor symposia on quantitative biology 1992;57():1-15.
1991: D L Milligan; Daniel E Koshland
Intrasubunit signal transduction by the aspartate chemoreceptor.
Science (New York, N.Y.) 1991;254(5038):1651-4.
1991: B H Morimoto; C C Chuang; Daniel E Koshland
Molecular cloning of a member of a new class of low-molecular-weight GTP-binding proteins.
Genes & development 1991;5(12B):2386-91.
1991: B H Morimoto; Daniel E Koshland
Identification of cyclic AMP as the response regulator for neurosecretory potentiation: a memory model system.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(23):10835-9.
1991: Berkley Lynch; Daniel E Koshland
Disulfide cross-linking studies of the transmembrane regions of the aspartate sensory receptor of Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(23):10402-6.
1991: M V Milburn; G G Privé; D L Milligan; William G Scott; J Yeh; J Jancarik; Daniel E Koshland; Sung-Huo S H Kim
Three-dimensional structures of the ligand-binding domain of the bacterial aspartate receptor with and without a ligand.
Science (New York, N.Y.) 1991;254(5036):1342-7.
1991: J Jancarik; William G Scott; D L Milligan; Daniel E Koshland; Sung-Huo S H Kim
Crystallization and preliminary X-ray diffraction study of the ligand-binding domain of the bacterial chemotaxis-mediating aspartate receptor of Salmonella typhimurium.
Journal of molecular biology 1991;221(1):31-4.
1991: P T Martin; Daniel E Koshland
The biochemistry of the neuron. Neurosecretory habituation to repetitive depolarizations in PC12 cells.
The Journal of biological chemistry 1991;266(12):7388-92.
1991: B H Morimoto; Daniel E Koshland
Short-term and long-term memory in single cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1991;5(7):2061-7.
1991: P Dunten; Daniel E Koshland
Tuning the responsiveness of a sensory receptor via covalent modification.
The Journal of biological chemistry 1991;266(3):1491-6.
1990: B H Morimoto; Daniel E Koshland
Induction and expression of long- and short-term neurosecretory potentiation in a neural cell line.
Neuron 1990;5(6):875-80.
1990: A M Dean; Daniel E Koshland
Electrostatic and steric contributions to regulation at the active site of isocitrate dehydrogenase.
Science (New York, N.Y.) 1990;249(4972):1044-6.
1990: A J Flint; R D Paladini; Daniel E Koshland
Autophosphorylation of protein kinase C at three separated regions of its primary sequence.
Science (New York, N.Y.) 1990;249(4967):408-11.
1990: A C Newton; Daniel E Koshland
Phosphatidylserine affects specificity of protein kinase C substrate phosphorylation and autophosphorylation.
Biochemistry 1990;29(28):6656-61.
1990: B H Morimoto; Daniel E Koshland
Excitatory amino acid uptake and N-methyl-D-aspartate-mediated secretion in a neural cell line.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(9):3518-21.
1990: P N McFadden; Daniel E Koshland
Parallel pathways for habituation in repetitively stimulated PC12 cells.
Neuron 1990;4(4):615-21.
1990: D L Milligan; Daniel E Koshland
The amino terminus of the aspartate chemoreceptor is formylmethionine.
The Journal of biological chemistry 1990;265(8):4455-60.
1990: P N McFadden; Daniel E Koshland
Habituation in the single cell: diminished secretion of norepinephrine with repetitive depolarization of PC12 cells.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(5):2031-5.
1990: R M Weis; Daniel E Koshland
Chemotaxis in Escherichia coli proceeds efficiently from different initial tumble frequencies.
Journal of bacteriology 1990;172(2):1099-105.
1989: David Avram Sanders; B L Gillece-Castro; A M Stock; Al L Burlingame; Daniel E Koshland
Identification of the site of phosphorylation of the chemotaxis response regulator protein, CheY.
The Journal of biological chemistry 1989;264(36):21770-8.
1989: A M Dean; M H Lee; Daniel E Koshland
Phosphorylation inactivates Escherichia coli isocitrate dehydrogenase by preventing isocitrate binding.
The Journal of biological chemistry 1989;264(34):20482-6.
1989: Scot C Kuo; Daniel E Koshland
Multiple kinetic states for the flagellar motor switch.
Journal of bacteriology 1989;171(11):6279-87.
1989: David Avram Sanders; B Mendez; Daniel E Koshland
Role of the CheW protein in bacterial chemotaxis: overexpression is equivalent to absence.
Journal of bacteriology 1989;171(11):6271-8.
1989: A C Newton; Daniel E Koshland
High cooperativity, specificity, and multiplicity in the protein kinase C-lipid interaction.
The Journal of biological chemistry 1989;264(25):14909-15.
1989: P N McFadden; A Mandpe; Daniel E Koshland
Calcium- and lipid-independent protein kinase C autophosphorylation. Activation by low pH.
The Journal of biological chemistry 1989;264(22):12765-71.
1989: G R Moe; G E Bollag; Daniel E Koshland
Transmembrane signaling by a chimera of the Escherichia coli aspartate receptor and the human insulin receptor.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(15):5683-7.
1988: David Avram Sanders; Daniel E Koshland
Receptor interactions through phosphorylation and methylation pathways in bacterial chemotaxis.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(22):8425-9.
1988: J J Falke; Abby F Dernburg; D A Sternberg; N Zalkin; D L Milligan; Daniel E Koshland
Structure of a bacterial sensory receptor. A site-directed sulfhydryl study.
The Journal of biological chemistry 1988;263(29):14850-8.
1988: Daniel E Koshland
Chemotaxis as a model second-messenger system.
Biochemistry 1988;27(16):5829-34.
1988: D L Milligan; Daniel E Koshland
Site-directed cross-linking. Establishing the dimeric structure of the aspartate receptor of bacterial chemotaxis.
The Journal of biological chemistry 1988;263(13):6268-75.
1988: Daniel E Koshland; David Avram Sanders; R M Weis
Roles of methylation and phosphorylation in the bacterial sensing system.
Cold Spring Harbor symposia on quantitative biology 1988;53 Pt 1():11-7.
1988: R M Weis; Daniel E Koshland
Reversible receptor methylation is essential for normal chemotaxis of Escherichia coli in gradients of aspartic acid.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(1):83-7.
1987: K Walsh; M Schena; A J Flint; Daniel E Koshland
Compensatory regulation in metabolic pathways--responses to increases and decreases in citrate synthase levels.
Biochemical Society symposium 1987;54():183-95.
1987: P E Thorsness; S L Mowbray; Daniel E Koshland
Transmission of regulatory conformational changes through proteins.
Cold Spring Harbor symposia on quantitative biology 1987;52():623-30.
1987: Daniel E Koshland
Evolution of catalytic function.
Cold Spring Harbor symposia on quantitative biology 1987;52():1-7.
1986: L Ellis; D O Morgan; Daniel E Koshland; E Clauser; G R Moe; G Bollag; R A Roth; W J Rutter
Linking functional domains of the human insulin receptor with the bacterial aspartate receptor.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(21):8137-41.