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Michele Kosiewicz

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Michele M Kosiewicz; Arin L Zirnheld; Pascale Alard
Tuning of skin immunity by skin commensal bacteria.
Michele M Kosiewicz; Dominick L Auci; Paolo Fagone; Katia Mangano; Salvatore Caponnetto; Colleen F Tucker; Nabeel Azeem; Steven White; James M Frincke; Christopher L Reading; Ferdinando Nicoletti
HE3286, an orally bioavailable synthetic analogue of an active DHEA metabolite suppresses spontaneous autoimmune diabetes in the non-obese diabetic (NOD) mouse.
Michele M Kosiewicz; Anita Y Chhabra; Arin L Zirnheld; Pascale Alard
CD8+ suppressor cells resurrected and vindicated.

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All Publications

2013: Michele M Kosiewicz; Arin L Zirnheld; Pascale Alard
Tuning of skin immunity by skin commensal bacteria.
Immunotherapy 2013;5(1):23-5.
2011: Michele M Kosiewicz; Dominick L Auci; Paolo Fagone; Katia Mangano; Salvatore Caponnetto; Colleen F Tucker; Nabeel Azeem; Steven White; James M Frincke; Christopher L Reading; Ferdinando Nicoletti
HE3286, an orally bioavailable synthetic analogue of an active DHEA metabolite suppresses spontaneous autoimmune diabetes in the non-obese diabetic (NOD) mouse.
European journal of pharmacology 2011;658(2-3):257-62.
2011: Michele M Kosiewicz; Anita Y Chhabra; Arin L Zirnheld; Pascale Alard
CD8+ suppressor cells resurrected and vindicated.
Immunotherapy 2011;3(3):316-7.
2011: Michele M Kosiewicz; Anita Y Chhabra; Arin L Zirnheld; Pascale Alard
β-catenin: does it have a role in tolerance?
Immunotherapy 2011;3(3):314-6.
2011: Michele M Kosiewicz; Anita Y Chhabra; Arin L Zirnheld; Pascale Alard
Commensal flora: friends or foes?
Immunotherapy 2011;3(3):313-4.
2011: Michele M Kosiewicz; Arin L Zirnheld; Pascale Alard
Gut microbiota, immunity, and disease: a complex relationship.
Frontiers in microbiology 2011;2():180.
2011: Jean N Manirarora; Sarah A Parnell; Yoon-Hyeon Hu; Michele M Kosiewicz; Pascale Alard
NOD dendritic cells stimulated with Lactobacilli preferentially produce IL-10 versus IL-12 and decrease diabetes incidence.
Clinical & developmental immunology 2011;2011():630187.
2008: Carlos A Garcia; Manjunatha Benakanakere; Pascale Alard; Michele M Kosiewicz; Denis F Kinane; Michael Martin
Antigenic experience dictates functional role of glycogen synthase kinase-3 in human CD4+ T cell responses.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(12):8363-71.
2008: Jean N Manirarora; Michele M Kosiewicz; Sarah A Parnell; Pascale Alard
APC activation restores functional CD4(+)CD25(+) regulatory T cells in NOD mice that can prevent diabetes development.
PloS one 2008;3(11):e3739.
2007: Deanna D H Franke; Esma S Yolcu; Pascale Alard; Michele M Kosiewicz; Haval Shirwan
A novel multimeric form of FasL modulates the ability of diabetogenic T cells to mediate type 1 diabetes in an adoptive transfer model.
Molecular immunology 2007;44(11):2884-92.
2006: Mehmet O Kilinc; Karanvir S Aulakh; Raji E Nair; Stacy A Jones; Pascale Alard; Michele M Kosiewicz; Nejat K Egilmez
Reversing tumor immune suppression with intratumoral IL-12: activation of tumor-associated T effector/memory cells, induction of T suppressor apoptosis, and infiltration of CD8+ T effectors.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(10):6962-73.
2006: Pascale Alard; Jean N Manirarora; Sarah A Parnell; Jason L Hudkins; Sherry L Clark; Michele M Kosiewicz
Deficiency in NOD antigen-presenting cell function may be responsible for suboptimal CD4+CD25+ T-cell-mediated regulation and type 1 diabetes development in NOD mice.
Diabetes 2006;55(7):2098-105.
2005: Shuang Liang; Pascale Alard; Yuan Zhao; Sarah Parnell; Sherry L Clark; Michele M Kosiewicz
Conversion of CD4+ CD25- cells into CD4+ CD25+ regulatory T cells in vivo requires B7 costimulation, but not the thymus.
The Journal of experimental medicine 2005;201(1):127-37.
2004: Michele M Kosiewicz; Pascale Alard; Shuang Liang; Sherry L Clark
Mechanisms of tolerance induced by transforming growth factor-beta-treated antigen-presenting cells: CD8 regulatory T cells inhibit the effector phase of the immune response in primed mice through a mechanism involving Fas ligand.
International immunology 2004;16(5):697-706.
2004: Pascale Alard; Sherry L Clark; Michele M Kosiewicz
Mechanisms of tolerance induced by TGF beta-treated APC: CD4 regulatory T cells prevent the induction of the immune response possibly through a mechanism involving TGF beta.
European journal of immunology 2004;34(4):1021-30.
2004: Michele M Kosiewicz; Pascale Alard
Tolerogenic antigen-presenting cells: regulation of the immune response by TGF-beta-treated antigen-presenting cells.
Immunologic research 2004;30(2):155-70.
2003: Pascale Alard; Sherry L Clark; Michele M Kosiewicz
Deletion, but not anergy, is involved in TGF-beta-treated antigen-presenting cell-induced tolerance.
International immunology 2003;15(8):945-53.
2002: Michele M Kosiewicz; Anasuya Krishnan; Mark Worthington; James A Matriano; William G Ross
B cells engineered to express Fas ligand suppress pre-sensitized antigen-specific T cell responses in vivo.
European journal of immunology 2002;32(6):1679-87.
2001: Michele M Kosiewicz; Cynthia C Nast; A Krishnan; Jesús Rivera-Nieves; Christopher A Moskaluk; S Matsumoto; Kosuke Kozaiwa; Fabio Cominelli
Th1-type responses mediate spontaneous ileitis in a novel murine model of Crohn's disease.
The Journal of clinical investigation 2001;107(6):695-702.
1998: Michele M Kosiewicz; Pascale Alard; J Wayne Streilein
Alterations in cytokine production following intraocular injection of soluble protein antigen: impairment in IFN-gamma and induction of TGF-beta and IL-4 production.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(10):5382-90.
1997: J Wayne Streilein; S Okamoto; Y Hara; Michele M Kosiewicz; Bruce R Ksander
Blood-borne signals that induce anterior chamber-associated immune deviation after intracameral injection of antigen.
Investigative ophthalmology & visual science 1997;38(11):2245-54.
1997: M Takeuchi; Michele M Kosiewicz; Pascale Alard; J Wayne Streilein
On the mechanisms by which transforming growth factor-beta 2 alters antigen-presenting abilities of macrophages on T cell activation.
European journal of immunology 1997;27(7):1648-56.
1997: S Grisanti; M Ishioka; Michele M Kosiewicz; L Q Jiang
Immunity and immune privilege elicited by cultured retinal pigment epithelial cell transplants.
Investigative ophthalmology & visual science 1997;38(8):1619-26.
1996: Michele M Kosiewicz; J Wayne Streilein
Intraocular injection of class II-restricted peptide induces an unexpected population of CD8 regulatory cells.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(5):1905-12.
1996: Pascale Alard; Robert B Levy; Michele M Kosiewicz; M Jones; J Wayne Streilein
MHC class II tolerant T cells undergo apoptosis upon re-exposure to tolerogen in vivo.
Transplant immunology 1996;4(1):76-80.