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Atsushi Kosugi

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Natsuko Tanimura; Shin-ichiroh Saitoh; Sunao Kawano; Atsushi Kosugi; Kensuke Miyake
Palmitoylation of LAT contributes to its subcellular localization and stability.
Shizue Tani-Ichi; Koji Maruyama; Nami Kondo; Masakazu Nagafuku; Kazuya Kabayama; Jin-ichi Inokuchi; Yukiko Shimada; Yoshiko Ohno-Iwashita; Hideo Yagita; Sunao Kawano; Atsushi Kosugi
Structure and function of lipid rafts in human activated T cells.
Masakazu Nagafuku; Atsushi Kosugi
[Th and Tc cell development--from naïve to memory cells].

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2006: Natsuko Tanimura; Shin-ichiroh Saitoh; Sunao Kawano; Atsushi Kosugi; Kensuke Miyake
Palmitoylation of LAT contributes to its subcellular localization and stability.
Biochemical and biophysical research communications 2006;341(4):1177-83.
2005: Shizue Tani-Ichi; Koji Maruyama; Nami Kondo; Masakazu Nagafuku; Kazuya Kabayama; Jin-ichi Inokuchi; Yukiko Shimada; Yoshiko Ohno-Iwashita; Hideo Yagita; Sunao Kawano; Atsushi Kosugi
Structure and function of lipid rafts in human activated T cells.
International immunology 2005;17(6):749-58.
2005: Masakazu Nagafuku; Atsushi Kosugi
[Th and Tc cell development--from naïve to memory cells].
Nihon rinsho. Japanese journal of clinical medicine 2005;63 Suppl 4():347-54.
2004: Shin-ichiroh Saitoh; Sachiko Akashi; Takenao Yamada; Natsuko Tanimura; Makiko Kobayashi; Kazunori Konno; Fumi Matsumoto; Koichi Fukase; Shoichi Kusumoto; Yoshinori Nagai; Yutaka Kusumoto; Atsushi Kosugi; Kensuke Miyake
Lipid A antagonist, lipid IVa, is distinct from lipid A in interaction with Toll-like receptor 4 (TLR4)-MD-2 and ligand-induced TLR4 oligomerization.
International immunology 2004;16(7):961-9.
2004: Shin-ichiroh Saitoh; Sachiko Akashi; Takenao Yamada; Natsuko Tanimura; Fumi Matsumoto; Koichi Fukase; Shoichi Kusumoto; Atsushi Kosugi; Kensuke Miyake
Ligand-dependent Toll-like receptor 4 (TLR4)-oligomerization is directly linked with TLR4-signaling.
Journal of endotoxin research 2004;10(4):257-60.
2003: Masakazu Nagafuku; Kazuya Kabayama; Daisuke Oka; Akiko Kato; Shizue Tani-Ichi; Yukiko Shimada; Yoshiko Ohno-Iwashita; Sho Yamasaki; Takashi Saito; Kazuya Iwabuchi; Toshiyuki Hamaoka; Jin-ichi Inokuchi; Atsushi Kosugi
Reduction of glycosphingolipid levels in lipid rafts affects the expression state and function of glycosylphosphatidylinositol-anchored proteins but does not impair signal transduction via the T cell receptor.
The Journal of biological chemistry 2003;278(51):51920-7.
2003: Naoya Hatano; Yoshiko Mori; Masatsugu Oh-hora; Atsushi Kosugi; Takahiko Fujikawa; Naoya Nakai; Hitoshi Niwa; Jun-ichi Miyazaki; Toshiyuki Hamaoka; Masato Ogata
Essential role for ERK2 mitogen-activated protein kinase in placental development.
Genes to cells : devoted to molecular & cellular mechanisms 2003;8(11):847-56.
2003: Sachiko Akashi; Shin-ichiroh Saitoh; Yasutaka Wakabayashi; Takane Kikuchi; Noriaki Takamura; Yoshinori Nagai; Yutaka Kusumoto; Koichi Fukase; Shoichi Kusumoto; Yoshiyuki Adachi; Atsushi Kosugi; Kensuke Miyake
Lipopolysaccharide interaction with cell surface Toll-like receptor 4-MD-2: higher affinity than that with MD-2 or CD14.
The Journal of experimental medicine 2003;198(7):1035-42.
2003: Natsuko Tanimura; Masakazu Nagafuku; Douglas R Liddicoat; Toshiyuki Hamaoka; Atsushi Kosugi
Analysis of the mobility of signaling molecules in lymphocytes using fluorescence photobleaching techniques.
Science's STKE : signal transduction knowledge environment 2003;2003(185):pl10.
2003: Natsuko Tanimura; Masakazu Nagafuku; Yasuko Minaki; Yukio Umeda; Fumie Hayashi; Junko Sakakura; Akiko Kato; Douglas R Liddicoat; Masato Ogata; Toshiyuki Hamaoka; Atsushi Kosugi
Dynamic changes in the mobility of LAT in aggregated lipid rafts upon T cell activation.
The Journal of cell biology 2003;160(1):125-35.
2002: Shin-ichiroh Saitoh; Masakazu Nagafuku; Atsushi Kosugi
[T cell membrane raft domains: its function in T cell activation].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2002;47(16 Suppl):2234-41.
2002: Koubun Yasuda; Masakazu Nagafuku; Takaki Shima; Masato Okada; Takeshi Yagi; Takenao Yamada; Yasuko Minaki; Akiko Kato; Shizue Tani-Ichi; Toshiyuki Hamaoka; Atsushi Kosugi
Cutting edge: Fyn is essential for tyrosine phosphorylation of Csk-binding protein/phosphoprotein associated with glycolipid-enriched microdomains in lipid rafts in resting T cells.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(6):2813-7.
2002: Hiroshi Inoue; Michihiko Miyaji; Atsushi Kosugi; Masakazu Nagafuku; Toshiro Okazaki; Tsuneyo Mimori; Ryuichi Amakawa; Shirou Fukuhara; Naochika Domae; Eda T Bloom; Hisanori Umehara
Lipid rafts as the signaling scaffold for NK cell activation: tyrosine phosphorylation and association of LAT with phosphatidylinositol 3-kinase and phospholipase C-gamma following CD2 stimulation.
European journal of immunology 2002;32(8):2188-98.
2002: Yoshinori Nagai; Sachiko Akashi; Masakazu Nagafuku; Masato Ogata; Yoichiro Iwakura; Shizuo Akira; Toshio Kitamura; Atsushi Kosugi; Masao Kimoto; Kensuke Miyake
Essential role of MD-2 in LPS responsiveness and TLR4 distribution.
Nature immunology 2002;3(7):667-72.
2002: Hideaki Nakajima; Masaru Takenaka; Jun-Ya Kaimori; Yasuyuki Nagasawa; Atsushi Kosugi; Shouko Kawamoto; Enyu Imai; Masatsugu Hori; Kousaku Okubo
Gene expression profile of renal proximal tubules regulated by proteinuria.
Kidney international 2002;61(5):1577-87.
2002: Masakazu Nagafuku; Atsushi Kosugi
[T cell membrane raft: its structure and function].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2002;47(4 Suppl):385-93.
2002: Kensuke Miyake; Yoshinori Nagai; Sachiko Akashi; Masakazu Nagafuku; Masato Ogata; Atsushi Kosugi
Essential role of MD-2 in B-cell responses to lipopolysaccharide and Toll-like receptor 4 distribution.
Journal of endotoxin research 2002;8(6):449-52.
2001: Atsushi Kosugi; J Sakakura; Koubun Yasuda; Masato Ogata; Toshiyuki Hamaoka
Involvement of SHP-1 tyrosine phosphatase in TCR-mediated signaling pathways in lipid rafts.
Immunity 2001;14(6):669-80.
2001: Hiroko Fujimoto; Y Tanaka; Zhao-Jun Liu; Hideo Yagita; K Okumura; Atsushi Kosugi; Akio Morinobu; H Umehara; Hirohei Yamamura; Yasuhiro Minami
Down-regulation of alpha6 integrin, an anti-oncogene product, by functional cooperation of H-Ras and c-Myc.
Genes to cells : devoted to molecular & cellular mechanisms 2001;6(4):337-43.
2001: Atsushi Kosugi; Fumie Hayashi; Douglas R Liddicoat; Koubun Yasuda; Shin-ichiroh Saitoh; Toshiyuki Hamaoka
A pivotal role of cysteine 3 of Lck tyrosine kinase for localization to glycolipid-enriched microdomains and T cell activation.
Immunology letters 2001;76(2):133-8.
2000: Koubun Yasuda; Atsushi Kosugi; Fumie Hayashi; Shin-ichiroh Saitoh; Masakazu Nagafuku; Yasuo Mori; Masato Ogata; Toshiyuki Hamaoka
Serine 6 of Lck tyrosine kinase: a critical site for Lck myristoylation, membrane localization, and function in T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(6):3226-31.
2000: K Yasuda; Atsushi Kosugi
[The role of lipid rafts in T cell receptor (TCR) signaling].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2000;45(11):1812-22.
1999: Atsushi Kosugi; Shin-ichiroh Saitoh; S Noda; Koubun Yasuda; Fumie Hayashi; M Ogata; Toshiyuki Hamaoka
Translocation of tyrosine-phosphorylated TCRzeta chain to glycolipid-enriched membrane domains upon T cell activation.
International immunology 1999;11(9):1395-401.
1999: Masatsugu Oh-hora; Masato Ogata; Yasuo Mori; Masashi Adachi; K Imai; Atsushi Kosugi; Toshiyuki Hamaoka
Direct suppression of TCR-mediated activation of extracellular signal-regulated kinase by leukocyte protein tyrosine phosphatase, a tyrosine-specific phosphatase.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(3):1282-8.
1999: Masato Ogata; T Takada; Yasuo Mori; Yohzo Uchida; Tsuneharu Miki; A Okuyama; Atsushi Kosugi; M Sawada; Masatsugu Oh-hora; Toshiyuki Hamaoka
Regulation of phosphorylation level and distribution of PTP36, a putative protein tyrosine phosphatase, by cell-substrate adhesion.
The Journal of biological chemistry 1999;274(29):20717-24.
1999: Masato Ogata; T Takada; Yasuo Mori; Masatsugu Oh-hora; Yohzo Uchida; Atsushi Kosugi; K Miyake; Toshiyuki Hamaoka
Effects of overexpression of PTP36, a putative protein tyrosine phosphatase, on cell adhesion, cell growth, and cytoskeletons in HeLa cells.
The Journal of biological chemistry 1999;274(18):12905-9.
1999: Masato Ogata; Masatsugu Oh-hora; Atsushi Kosugi; Toshiyuki Hamaoka
Inactivation of mitogen-activated protein kinases by a mammalian tyrosine-specific phosphatase, PTPBR7.
Biochemical and biophysical research communications 1999;256(1):52-6.
1998: Atsushi Kosugi; S Saitoh; S Noda; K Miyake; Y Yamashita; M Kimoto; Masato Ogata; Toshiyuki Hamaoka
Physical and functional association between thymic shared antigen-1/stem cell antigen-2 and the T cell receptor complex.
The Journal of biological chemistry 1998;273(20):12301-6.
1997: Atsushi Kosugi; S Noda; S Saitoh; S Narumiya; M Ogata; Y Hashimoto; K Takase; T Saito; Toshiyuki Hamaoka
Subunit composition of the pre-T-cell receptor complex analysed by monoclonal antibody against the pre-T-cell receptor alpha chain.
Immunology 1997;91(4):618-22.
1996: Tatsuo Furuyama; Shinobu Inagaki; Atsushi Kosugi; S Noda; S Saitoh; Masato Ogata; Y Iwahashi; N Miyazaki; Toshiyuki Hamaoka; Masaya Tohyama
Identification of a novel transmembrane semaphorin expressed on lymphocytes.
The Journal of biological chemistry 1996;271(52):33376-81.
1996: S Noda; Atsushi Kosugi; S Saitoh; S Narumiya; Toshiyuki Hamaoka
Protection from anti-TCR/CD3-induced apoptosis in immature thymocytes by a signal through thymic shared antigen-1/stem cell antigen-2.
The Journal of experimental medicine 1996;183(5):2355-60.
1995: S Saitoh; Atsushi Kosugi; S Noda; N Yamamoto; Masato Ogata; Yasuhiro Minami; K Miyake; Toshiyuki Hamaoka
Modulation of TCR-mediated signaling pathway by thymic shared antigen-1 (TSA-1)/stem cell antigen-2 (Sca-2).
Journal of immunology (Baltimore, Md. : 1950) 1995;155(12):5574-81.
1995: Atsushi Kosugi; S Noda; T Nagata-Narumiya; Toshiyuki Hamaoka
A physiological interaction of T cells and Mac-1+ cells is not necessary to induce the selective loss of CD3zeta chains in tumor-bearing state.
Immunology letters 1995;47(3):233-5.
1995: S Noda; T Nagata-Narumiya; Atsushi Kosugi; S Narumiya; C Ra; Hiromi Fujiwara; Toshiyuki Hamaoka
Do structural changes of T cell receptor complex occur in tumor-bearing state?
Japanese journal of cancer research : Gann 1995;86(4):383-94.
1994: Masato Ogata; M Sawada; Atsushi Kosugi; Toshiyuki Hamaoka
Developmentally regulated expression of a murine receptor-type protein tyrosine phosphatase in the thymus.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(10):4478-87.
1993: H Iwata; Satoru Kitagawa-Sakakida; S Sato; Atsushi Kosugi; H Hirose; Toshiyuki Hamaoka; G M Shearer; Hiromi Fujiwara
Suppression of allograft responses by combining donor alloantigen-specific intravenous presensitization with suboptimal doses of FK506.
Transplantation 1993;56(1):173-80.
1992: M Sawada; J Nagamine; K Takeda; K Utsumi; Atsushi Kosugi; Y Tatsumi; Toshiyuki Hamaoka; K Miyake; K Nakajima; T Watanabe
Expression of VLA-4 on thymocytes. Maturation stage-associated transition and its correlation with their capacity to adhere to thymic stromal cells.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(11):3517-24.
1992: Atsushi Kosugi; A M Weissman; Masato Ogata; Toshiyuki Hamaoka; Hiromi Fujiwara
Instability of assembled T-cell receptor complex that is associated with rapid degradation of zeta chains in immature CD4+CD8+ thymocytes.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(20):9494-8.
1989: J Shimizu; T Suda; T Yoshioka; Atsushi Kosugi; Hiromi Fujiwara; Toshiyuki Hamaoka
Induction of tumor-specific in vivo protective immunity by immunization with tumor antigen-pulsed antigen-presenting cells.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(3):1053-9.
1987: Atsushi Kosugi; T Yoshioka; T Suda; H Sano; Y Takahama; Hiromi Fujiwara; Toshiyuki Hamaoka
The activation of L3T4+ helper T cells assisting the generation of anti-tumor Lyt-2+ cytotoxic T lymphocytes: requirement of Ia-positive antigen-presenting cells for processing and presentation of tumor antigens.
Journal of leukocyte biology 1987;42(6):632-41.
1987: J Shima; T Yoshioka; Atsushi Kosugi; Masato Ogata; Hiromi Fujiwara; Toshiyuki Hamaoka; S Ueda; S Kato
Differential ability of tumor-unique and cross-reactive antigen(s) on two murine hepatoma cell lines to induce Lyt-1+2- T cells responsible for in vivo protective immunity.
Biken journal 1987;30(1):1-8.
1987: H Sano; Atsushi Kosugi; S Sano; Hiromi Fujiwara; Toshiyuki Hamaoka
The augmentation of tumor-specific immunity using haptenic muramyl dipeptide (MDP) derivatives. II. Establishment of tumor-specific immunotherapy models utilizing MDP hapten-reactive helper T cell activity.
Cancer immunology, immunotherapy : CII 1987;25(3):180-4.
1987: Hiromi Fujiwara; J Shima; H Sano; Atsushi Kosugi; Hiromu Nakajima; Toshiyuki Hamaoka
Tumor-specific immunotherapy by active immunization with haptenic muramyl dipeptide derivative-coupled tumor cells.
Progress in clinical and biological research 1987;244():335-44.
1986: Atsushi Kosugi; J Shima; H Sano; M Ogata; T Kusama; Hiromi Fujiwara; Toshiyuki Hamaoka
Cross-reactivity between haptenic muramyl di- or tripeptide derivatives and Mycobacterium bovis BCG: potential application for enhancing tumor immunity.
Infection and immunity 1986;54(3):768-73.
1986: Hiromi Fujiwara; T Yoshioka; J Shima; Atsushi Kosugi; K Itoh; Toshiyuki Hamaoka
Helper T cells against tumor-associated antigens (TAA): preferential induction of helper T cell activities involved in anti-TAA cytotoxic T lymphocyte and antibody responses.
Journal of immunology (Baltimore, Md. : 1950) 1986;136(7):2715-9.
1985: Toshiyuki Hamaoka; Y Takai; Atsushi Kosugi; Y Mizushima; J Shima; T Kusama; Hiromi Fujiwara
The augmentation of tumor-specific immunity using haptenic muramyl dipeptide (MDP) derivatives. I. Synthesis of a novel haptenic MDP derivative cross-reactive with Bacillus Calmette Guerin and its application to enhanced induction of tumor immunity.
Cancer immunology, immunotherapy : CII 1985;20(3):183-8.