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Malak Kotb

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Yi Shu; Zhenqi Zhu; Farzin Haque; Malak Kotb; Wei Li; Yuri Lyubchenko; Dan Shu; Peixuan Guo
Fabrication of 14 different RNA nanoparticles for specific tumor targeting without accumulation in normal organs.
Rajendra Tandon; Magdi H Yacoub; Y Chandrashekhar; Malak Kotb; Meenakshi Sharma; Jagat Narula
Revisiting the pathogenesis of rheumatic fever and carditis.
Elizabeth E Zumbrun; Donald K Nichols; Nourtan F Abdeltawab; Holly A Bloomfield; Taylor B Chance; Paige E Harrison; Malak Kotb; Aysegul Nalca
Development of a murine model for aerosolized ebolavirus infection using a panel of recombinant inbred mice.

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2013: Yi Shu; Zhenqi Zhu; Farzin Haque; Malak Kotb; Wei Li; Yuri Lyubchenko; Dan Shu; Peixuan Guo
Fabrication of 14 different RNA nanoparticles for specific tumor targeting without accumulation in normal organs.
RNA (New York, N.Y.) 2013;19(6):767-77.
2013: Rajendra Tandon; Magdi H Yacoub; Y Chandrashekhar; Malak Kotb; Meenakshi Sharma; Jagat Narula
Revisiting the pathogenesis of rheumatic fever and carditis.
Nature reviews. Cardiology 2013;10(3):171-7.
2012: Elizabeth E Zumbrun; Donald K Nichols; Nourtan F Abdeltawab; Holly A Bloomfield; Taylor B Chance; Paige E Harrison; Malak Kotb; Aysegul Nalca
Development of a murine model for aerosolized ebolavirus infection using a panel of recombinant inbred mice.
Viruses 2012;4(12):3468-93.
2012: Peter G Maamary; Jason McArthur; Victor Nizet; Martina Sanderson-Smith; WL Taylor; Carola Venturini; Ramy Aziz; Timothy C Barnett; Scott A Beatson; Nouri BEN ZAKOUR; Jason N Cole; Amanda J Cork; Christine M Gillen; Anna Henningham; Andrew Hollands; Dwight R Johnson; Edward L Kaplan; Joshua K Kirk; Malak Kotb; Mark J Walker
Tracing the evolutionary history of the pandemic group A streptococcal M1T1 clone.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012;26(11):4675-84.
2012: Petra L Kohler; Malak Kotb; David M Kranz; Suba Nookala; Seth D Greenwood; Patrick M Schlievert
Staphylococcus aureus isolates encode variant staphylococcal enterotoxin B proteins that are diverse in superantigenicity and lethality.
PloS one 2012;7(7):e41157.
2012: Afaf K El-Ansary; Abir Ben Bacha; Malak Kotb
Etiology of autistic features: the persisting neurotoxic effects of propionic acid.
Journal of neuroinflammation 2012;9():74.
2012: Erika Hertzén; Marton Janos; Linda Johansson; Rita Kansal; Malak Kotb; Victor Nizet; Samira Dahesh; Alexander Hecht; Anna Norrby-Teglund
Intracellular Streptococcus pyogenes in human macrophages display an altered gene expression profile.
PloS one 2012;7(4):e35218.
2012: Laila Y Al-Ayadhi; Abir G Ben Bacha; Malak Kotb; Afaf K El-Ansary
A novel study on amyloid β peptide 40, 42 and 40/42 ratio in Saudi autistics.
Behavioral and brain functions : BBF 2012;8():4.
2011: Andrea V Page; Malak Kotb; Allison McGeer; Donald E Low; Kevin C Kain; W Conrad Liles
Systemic dysregulation of angiopoietin-1/2 in streptococcal toxic shock syndrome.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2011;52(8):e157-61.
2010: Ramy K Aziz; Rita Kansal; Bruce J Aronow; William L Taylor; Sarah L Rowe; Michael Kubal; Gursharan S Chhatwal; Mark J Walker; Malak Kotb
Microevolution of group A streptococci in vivo: capturing regulatory networks engaged in sociomicrobiology, niche adaptation, and hypervirulence.
PloS one 2010;5(4):e9798.
2009: A C M Boon; Jennifer deBeauchamp; Anna Hollmann; Jennifer Luke; Malak Kotb; ST Rowe; David Finkelstein; Geoffrey Neale; Lu Lu; Robert Williams; Richard J Webby
Host genetic variation affects resistance to infection with a highly pathogenic H5N1 influenza A virus in mice.
Journal of virology 2009;83(20):10417-26.
2008: Ramy R Attia; Lidia Gardner; Engy Mahrous; Debra J Taxman; Leighton H Legros; Sarah Rowe; Jenny P-Y Ting; A Geller; Malak Kotb
Selective targeting of leukemic cell growth in vivo and in vitro using a gene silencing approach to diminish S-adenosylmethionine synthesis.
The Journal of biological chemistry 2008;283(45):30788-95.
2008: Ramy Aziz; Malak Kotb
Rise and persistence of global M1T1 clone of Streptococcus pyogenes.
Emerging infectious diseases 2008;14(10):1511-7.
2008: Katherine J Kasper; Wang Xi; Mohammed M Nooh; Malak Kotb; Eric Sundberg; Joaquín Madrenas; A K M Nur-Ur Rahman; John K McCormick
Molecular requirements for MHC class II alpha-chain engagement and allelic discrimination by the bacterial superantigen streptococcal pyrogenic exotoxin C.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(5):3384-92.
2008: Nourtan Abdeltawab; Ramy Aziz; Rita Kansal; Sarah L Rowe; Yin Su; Lidia Gardner; Charity Brannen; Mohammed M Nooh; Ramy R Attia; Hossam A Abdelsamed; WL Taylor; Lu Lu; Robert Williams; Malak Kotb
An unbiased systems genetics approach to mapping genetic loci modulating susceptibility to severe streptococcal sepsis.
PLoS pathogens 2008;4(4):e1000042.
2008: Hanfen Li; Mohammed M Nooh; Malak Kotb; Fabio Re
Commercial peptidoglycan preparations are contaminated with superantigen-like activity that stimulates IL-17 production.
Journal of leukocyte biology 2008;83(2):409-18.
2008: Lisa I Påhlman; Anders I Olin; Jessica Darenberg; Matthias Mörgelin; Malak Kotb; Heiko Herwald; Anna Norrby-Teglund
Soluble M1 protein of Streptococcus pyogenes triggers potent T cell activation.
Cellular microbiology 2008;10(2):404-14.
2008: Andrew Hollands; Ramy Aziz; Rita Kansal; Malak Kotb; Victor Nizet; Mark J Walker
A naturally occurring mutation in ropB suppresses SpeB expression and reduces M1T1 group A streptococcal systemic virulence.
PloS one 2008;3(12):e4102.
2008: Malak Kotb; Nourtan Fathey; Ramy Aziz; Sarah Rowe; Robert Williams; Lu Lu
Unbiased forward genetics and systems biology approaches to understanding how gene-environment interactions work to predict susceptibility and outcomes of infections.
Novartis Foundation symposium 2008;293():156-65; discussion 165-7, 181-3.
2007: Jason N Cole; J Andrew Aquilina; Peter G Hains; Anna Henningham; Kadaba S Sriprakash; Michael G Caparon; Victor Nizet; Malak Kotb; Stuart J Cordwell; Steven P Djordjevic; Mark J Walker
Role of group A Streptococcus HtrA in the maturation of SpeB protease.
Proteomics 2007;7(24):4488-98.
2007: Janelle C Arthur; John David Lich; Ramy Aziz; Malak Kotb; Jenny P-Y Ting
Heat shock protein 90 associates with monarch-1 and regulates its ability to promote degradation of NF-kappaB-inducing kinase.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(9):6291-6.
2007: Mark J Walker; Andrew Hollands; Martina L Sanderson-Smith; Jason N Cole; Joshua K Kirk; Anna Henningham; Jason McArthur; Katrin Dinkla; Ramy Aziz; Rita G Kansal; Amelia J Simpson; John Buchanan; Gursharan S Chhatwal; Malak Kotb; Victor Nizet
DNase Sda1 provides selection pressure for a switch to invasive group A streptococcal infection.
Nature medicine 2007;13(8):981-5.
2007: Rita G Kansal; Catherine Davis; Melanie Hansmann; Jon Seymour; Jeffrey Parsonnet; Paul Modern; Steve Gilbert; Malak Kotb
Structural and functional properties of antibodies to the superantigen TSST-1 and their relationship to menstrual toxic shock syndrome.
Journal of clinical immunology 2007;27(3):327-38.
2007: Mohammed M Nooh; Nagala El-Gengehi; Rita G Kansal; Chella S David; Malak Kotb
HLA transgenic mice provide evidence for a direct and dominant role of HLA class II variation in modulating the severity of streptococcal sepsis.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(5):3076-83.
2007: Laura A Kwinn; Arya Khosravi; Ramy Aziz; Anjuli M Timmer; Kelly S Doran; Malak Kotb; Victor Nizet
Genetic characterization and virulence role of the RALP3/LSA locus upstream of the streptolysin s operon in invasive M1T1 Group A Streptococcus.
Journal of bacteriology 2007;189(4):1322-9.
2007: Omaima Sabek; Daniel W Fraga; James Henry; Lillian W Gaber; Malak Kotb; A Osama Gaber
Expression of transforming growth factor-beta by human islets: impact on islet viability and function.
Cell transplantation 2007;16(8):775-85.
2006: Mohammed M Nooh; Ramy Aziz; Malak Kotb; Alexey Eroshkin; Woei-Jer Chuang; Thomas Proft; Rita G Kansal
Streptococcal mitogenic exotoxin, SmeZ, is the most susceptible M1T1 streptococcal superantigen to degradation by the streptococcal cysteine protease, SpeB.
The Journal of biological chemistry 2006;281(46):35281-8.
2006: Esobe F Ohuoba; Rita G Kansal; Randall Hayden; Malak Kotb; Elisabeth E Adderson
Failure of viridans group streptococci causing bacteremia in pediatric oncology patients to express superantigens.
Journal of pediatric hematology/oncology 2006;28(9):627-9.
2006: Jason N Cole; Jason McArthur; Fiona C McKay; Martina L Sanderson-Smith; Amanda J Cork; Marie Ranson; Manfred Rohde; Andreas Itzek; Hongmin Sun; David Ginsburg; Malak Kotb; Victor Nizet; Gursharan S Chhatwal; Mark J Walker
Trigger for group A streptococcal M1T1 invasive disease.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(10):1745-7.
2006: Pontus Thulin; Linda Johansson; Donald E Low; Bing Siang Gan; Malak Kotb; Allison McGeer; Anna Norrby-Teglund
Viable group A streptococci in macrophages during acute soft tissue infection.
PLoS medicine 2006;3(3):e53.
2006: John Buchanan; Amelia J Simpson; Ramy Aziz; George Y Liu; Sascha Kristian; Malak Kotb; James R Feramisco; Victor Nizet
DNase expression allows the pathogen group A Streptococcus to escape killing in neutrophil extracellular traps.
Current biology : CB 2006;16(4):396-400.
2006: Mihalis I Panayiotidis; Sally P Stabler; Aftab Ahmad; Aglaia Pappa; Leighton H Legros; Daniel Hernandez-Saavedra; Barbara K Schneider; Robert H Allen; Vasilis Vasiliou; Joe M McCord; Malak Kotb; Carl W White
Activation of a novel isoform of methionine adenosyl transferase 2A and increased S-adenosylmethionine turnover in lung epithelial cells exposed to hyperoxia.
Free radical biology & medicine 2006;40(2):348-58.
2006: Ann K Cashion; Omaima Sabek; Carolyn Driscoll; Lillian W Gaber; Malak Kotb; Osama Gaber
Correlation of genetic markers of rejection with biopsy findings following human pancreas transplant.
Clinical transplantation 2006;20(1):106-12.
2005: Rita G Kansal; Ramy Aziz; Malak Kotb
Modulation of expression of superantigens by human transferrin and lactoferrin: a novel mechanism in host-Streptococcus interactions.
The Journal of infectious diseases 2005;191(12):2121-9.
2005: Leonard D Shultz; Bonnie L Lyons; Lisa M Burzenski; Bruce Gott; Xiaohua Chen; Stanley Chaleff; Malak Kotb; Stephen D Gillies; Marie King; Julie Mangada; Dale L Greiner; Rupert Handgretinger
Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(10):6477-89.
2005: Ramy Aziz; Robert A Edwards; William W Taylor; Donald E Low; Allison McGeer; Malak Kotb
Mosaic prophages with horizontally acquired genes account for the emergence and diversification of the globally disseminated M1T1 clone of Streptococcus pyogenes.
Journal of bacteriology 2005;187(10):3311-8.
2005: Vivekanand Datta; Sandra M Myskowski; Laura A Kwinn; Daniel N Chiem; Nissi M Varki; Rita G Kansal; Malak Kotb; Victor Nizet
Mutational analysis of the group A streptococcal operon encoding streptolysin S and its virulence role in invasive infection.
Molecular microbiology 2005;56(3):681-95.
2005: Dana R. Marshall; Omaima Sabek; Daniel W Fraga; Malak Kotb; A Osama Gaber
Examination of the molecular signature associated with islet dysfunction.
Transplantation proceedings 2005;37(2):1311-2.
2005: Daniel W Fraga; A Osama Gaber; Malak Kotb
Long-term culture and maintenance of human islets of Langerhans in memphis serum-free media.
Methods in molecular medicine 2005;107():303-11.
2004: Ramy Aziz; Shehab A Ismail; Hee-Won Park; Malak Kotb
Post-proteomic identification of a novel phage-encoded streptodornase, Sda1, in invasive M1T1 Streptococcus pyogenes.
Molecular microbiology 2004;54(1):184-97.
2004: Kun Cheng; Daniel W Fraga; C Zhang; Malak Kotb; A Osama Gaber; Ramareddy V Guntaka; Ram I Mahato
Adenovirus-based vascular endothelial growth factor gene delivery to human pancreatic islets.
Gene therapy 2004;11(14):1105-16.
2004: A Osama Gaber; Daniel W Fraga; Malak Kotb; Agnes Lo; Omaima Sabek; Kashif A Latif
Human islet graft function in NOD-SCID mice predicts clinical response in islet transplant recipients.
Transplantation proceedings 2004;36(4):1108-10.
2004: Ajit S Narang; Kun Cheng; James Henry; Chunxiang Zhang; Omaima Sabek; Daniel W Fraga; Malak Kotb; A Osama Gaber; Ram I Mahato
Vascular endothelial growth factor gene delivery for revascularization in transplanted human islets.
Pharmaceutical research 2004;21(1):15-25.
2004: Ramy Aziz; Michael J Pabst; Arthur Jeng; Rita G Kansal; Donald E Low; Victor Nizet; Malak Kotb
Invasive M1T1 group A Streptococcus undergoes a phase-shift in vivo to prevent proteolytic degradation of multiple virulence factors by SpeB.
Molecular microbiology 2004;51(1):123-34.
2003: Charles R Yates; Wenhui Zhang; Pengfei Song; Shen Li; A Osama Gaber; Malak Kotb; Marsha R Honaker; Rita R Alloway; Bernd Meibohm
The effect of CYP3A5 and MDR1 polymorphic expression on cyclosporine oral disposition in renal transplant patients.
Journal of clinical pharmacology 2003;43(6):555-64.
2003: Christopher S Callicutt; Omaima Sabek; Kazuhiko Fukatsu; Andrew H Lundberg; Lillian W Gaber; Henry G Wilcox; Malak Kotb; A Osama Gaber
Diminished lung injury with vascular adhesion molecule-1 blockade in choline-deficient ethionine diet-induced pancreatitis.
Surgery 2003;133(2):186-96.
2003: Rita G Kansal; Victor Nizet; Arthur Jeng; Woei-Jer Chuang; Malak Kotb
Selective modulation of superantigen-induced responses by streptococcal cysteine protease.
The Journal of infectious diseases 2003;187(3):398-407.
2003: Malak Kotb; Anna Norrby-Teglund; Allison McGeer; Karen Green; Donald E Low
Association of human leukocyte antigen with outcomes of infectious diseases: the streptococcal experience.
Scandinavian journal of infectious diseases 2003;35(9):665-9.
2003: Ram I Mahato; James Henry; Ajit S Narang; Omaima Sabek; Daniel W Fraga; Malak Kotb; A Osama Gaber
Cationic lipid and polymer-based gene delivery to human pancreatic islets.
Molecular therapy : the journal of the American Society of Gene Therapy 2003;7(1):89-100.
2002: Malak Kotb; Anna Norrby-Teglund; Allison McGeer; Hesham El-Sherbini; M Tevfik Dorak; Ayesha Khurshid; Karen Green; Jeanie Peeples; Judy Wade; Glenys Thomson; Benjamin Schwartz; Donald E Low
An immunogenetic and molecular basis for differences in outcomes of invasive group A streptococcal infections.
Nature medicine 2002;8(12):1398-404.
2002: Dong-An Wang; Ajit S Narang; Malak Kotb; A Osama Gaber; Duane D Miller; Sung Wan Kim; Ram I Mahato
Novel branched poly(ethylenimine)-cholesterol water-soluble lipopolymers for gene delivery.
Biomacromolecules 2002;3(6):1197-207.
2002: Omaima Sabek; M Tevfik Dorak; Malak Kotb; A Osama Gaber; Lillian W Gaber
Quantitative detection of T-cell activation markers by real-time PCR in renal transplant rejection and correlation with histopathologic evaluation.
Transplantation 2002;74(5):701-7.
2002: Anna Norrby-Teglund; Gerald Nepom; Malak Kotb
Differential presentation of group A streptococcal superantigens by HLA class II DQ and DR alleles.
European journal of immunology 2002;32(9):2570-7.
2002: Pengfei Song; Shen Li; Bernd Meibohm; A Osama Gaber; Marsha R Honaker; Malak Kotb; Charles R Yates
Detection of MDR1 single nucleotide polymorphisms C3435T and G2677T using real-time polymerase chain reaction: MDR1 single nucleotide polymorphism genotyping assay.
AAPS pharmSci 2002;4(4):E29.
2001: Anna Norrby-Teglund; Pontus Thulin; Bing Siang Gan; Malak Kotb; Allison McGeer; Jan Andersson; Donald E Low
Evidence for superantigen involvement in severe group a streptococcal tissue infections.
The Journal of infectious diseases 2001;184(7):853-60.
2001: S Harvey Mudd; Roberto Cerone; Maria Cristina Schiaffino; AR Fantasia; Giuseppe Minniti; Ubaldo Caruso; R Lorini; D Watkins; NV Matiaszuk; David S Rosenblatt; B Schwahn; R Rozen; Leighton H Legros; Malak Kotb; Antonieta Capdevila; Zigmund Luka; James D Finkelstein; Albert Tangerman; Sally P Stabler; Robert H Allen; Conrad Wagner
Glycine N-methyltransferase deficiency: a novel inborn error causing persistent isolated hypermethioninaemia.
Journal of inherited metabolic disease 2001;24(4):448-64.
2001: S U Kazmi; Rita G Kansal; Ramy Aziz; M Hooshdaran; Anna Norrby-Teglund; Donald E Low; A B Halim; Malak Kotb
Reciprocal, temporal expression of SpeA and SpeB by invasive M1T1 group a streptococcal isolates in vivo.
Infection and immunity 2001;69(8):4988-95.
2001: AB Halim; HL LeGros; ME Chamberlin; A Geller; Malak Kotb
Distinct patterns of protein binding to the MAT2A promoter in normal and leukemic T cells.
Biochimica et biophysica acta 2001;1540(1):32-42.
2001: Leighton H Legros; AB Halim; ME Chamberlin; A Geller; Malak Kotb
Regulation of the human MAT2B gene encoding the regulatory beta subunit of methionine adenosyltransferase, MAT II.
The Journal of biological chemistry 2001;276(27):24918-24.
2001: AB Halim; Leighton H Legros; ME Chamberlin; A Geller; Malak Kotb
Regulation of the human MAT2A gene encoding the catalytic alpha 2 subunit of methionine adenosyltransferase, MAT II: gene organization, promoter characterization, and identification of a site in the proximal promoter that is essential for its activity.
The Journal of biological chemistry 2001;276(13):9784-91.
2001: Andrew H Lundberg; Kazuhiko Fukatsu; Lillian W Gaber; S Callicutt; Malak Kotb; Henry G Wilcox; Kenneth A Kudsk; A Osama Gaber
Blocking pulmonary ICAM-1 expression ameliorates lung injury in established diet-induced pancreatitis.
Annals of surgery 2001;233(2):213-20.
2000: Anna Norrby-Teglund; S Chatellier; Donald E Low; Allison McGeer; Karen Green; Malak Kotb
Host variation in cytokine responses to superantigens determine the severity of invasive group A streptococcal infection.
European journal of immunology 2000;30(11):3247-55.
2000: Anna Norrby-Teglund; Nahla Ihendyane; Rita G Kansal; H Basma; Malak Kotb; Jan Andersson; L Hammarström
Relative neutralizing activity in polyspecific IgM, IgA, and IgG preparations against group A streptococcal superantigens.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2000;31(5):1175-82.
2000: Rita G Kansal; Allison McGeer; Donald E Low; Anna Norrby-Teglund; Malak Kotb
Inverse relation between disease severity and expression of the streptococcal cysteine protease, SpeB, among clonal M1T1 isolates recovered from invasive group A streptococcal infection cases.
Infection and immunity 2000;68(11):6362-9.
2000: Andrew H Lundberg; J W Eubanks; J Henry; Omaima Sabek; Malak Kotb; Lillian W Gaber; A Norby-Teglund; A Osama Gaber
Trypsin stimulates production of cytokines from peritoneal macrophages in vitro and in vivo.
Pancreas 2000;21(1):41-51.
2000: S Chatellier; Nahla Ihendyane; Rita G Kansal; F Khambaty; H Basma; Anna Norrby-Teglund; Donald E Low; Allison McGeer; Malak Kotb
Genetic relatedness and superantigen expression in group A streptococcus serotype M1 isolates from patients with severe and nonsevere invasive diseases.
Infection and immunity 2000;68(6):3523-34.
2000: Andrew H Lundberg; N Granger; J Russell; S Callicutt; Lillian W Gaber; Malak Kotb; Omaima Sabek; A Osama Gaber
Temporal correlation of tumor necrosis factor-alpha release, upregulation of pulmonary ICAM-1 and VCAM-1, neutrophil sequestration, and lung injury in diet-induced pancreatitis.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2000;4(3):248-57.
2000: S Chatellier; Malak Kotb
Preferential stimulation of human lymphocytes by oligodeoxynucleotides that copy DNA CpG motifs present in virulent genes of group A streptococci.
European journal of immunology 2000;30(4):993-1001.
2000: Andrew H Lundberg; DN Granger; J Russell; Omaima Sabek; J Henry; Lillian W Gaber; Malak Kotb; A Osama Gaber
Quantitative measurement of P- and E-selectin adhesion molecules in acute pancreatitis: correlation with distant organ injury.
Annals of surgery 2000;231(2):213-22.
2000: HL LeGros; AB Halim; AM Geller; Malak Kotb
Cloning, expression, and functional characterization of the beta regulatory subunit of human methionine adenosyltransferase (MAT II).
The Journal of biological chemistry 2000;275(4):2359-66.
1999: Carmen Castro; F A Ruiz; Isabel Pérez-Mato; Manuel M Sánchez del Pino; Leighton H Legros; AM Geller; Malak Kotb; Fernando J Corrales; José M Mato
Creation of a functional S-nitrosylation site in vitro by single point mutation.
FEBS letters 1999;459(3):319-22.
1999: AB Halim; Leighton H Legros; A Geller; Malak Kotb
Expression and functional interaction of the catalytic and regulatory subunits of human methionine adenosyltransferase in mammalian cells.
The Journal of biological chemistry 1999;274(42):29720-5.
1999: Y Guédez; A Kotby; Maha A El-Demellawy; A Galal; G Thomson; S Zaher; S Kassem; Malak Kotb
HLA class II associations with rheumatic heart disease are more evident and consistent among clinically homogeneous patients.
Circulation 1999;99(21):2784-90.
1999: H Basma; Anna Norrby-Teglund; Y Guedez; Allison McGeer; Donald E Low; O El-Ahmedy; Benjamin Schwartz; Malak Kotb
Risk factors in the pathogenesis of invasive group A streptococcal infections: role of protective humoral immunity.
Infection and immunity 1999;67(4):1871-7.
1999: Malak Kotb; W C Russell; Donna Hathaway; Lillian W Gaber; A Osama Gaber
The use of positive B cell flow cytometry crossmatch in predicting rejection among renal transplant recipients.
Clinical transplantation 1999;13(1 Pt 2):83-9.
1998: B Langkamp-Henken; Leonard R Johnson; Mary Jane Viar; AM Geller; Malak Kotb
Differential effect on polyamine metabolism in mitogen- and superantigen-activated human T-cells.
Biochimica et biophysica acta 1998;1425(2):337-47.
1998: J W Eubanks; Omaima Sabek; Malak Kotb; Lillian W Gaber; J Henry; N Hijiya; L G Britt; A Osama Gaber; Sanna Goyert
Acute pancreatitis induces cytokine production in endotoxin-resistant mice.
Annals of surgery 1998;227(6):904-11.
1998: H Basma; Anna Norrby-Teglund; Allison McGeer; Donald E Low; O El-Ahmedy; J B Dale; Benjamin Schwartz; Malak Kotb
Opsonic antibodies to the surface M protein of group A streptococci in pooled normal immunoglobulins (IVIG): potential impact on the clinical efficacy of IVIG therapy for severe invasive group A streptococcal infections.
Infection and immunity 1998;66(5):2279-83.
1998: Ivan C Gerling; Malak Kotb; Daniel W Fraga; Omaima Sabek; A Osama Gaber
No correlation between in vitro and in vivo function of human islets.
Transplantation proceedings 1998;30(2):587-8.
1998: Anna Norrby-Teglund; H Basma; Jan Andersson; Allison McGeer; Donald E Low; Malak Kotb
Varying titers of neutralizing antibodies to streptococcal superantigens in different preparations of normal polyspecific immunoglobulin G: implications for therapeutic efficacy.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 1998;26(3):631-8.
1998: Duane W Newton; M Dohlsten; PA Lando; T Kalland; C Olsson; Malak Kotb
MHC class II-independent, Vbeta-specific activation of T cells by superantigen mutants fused to anti-tumor Fab fragments: implications for use in treatment of human colon carcinoma.
International journal of molecular medicine 1998;1(1):157-62.
1997: Anna Norrby-Teglund; R Lustig; Malak Kotb
Differential induction of Th1 versus Th2 cytokines by group A streptococcal toxic shock syndrome isolates.
Infection and immunity 1997;65(12):5209-15.
1997: HL LeGros; AM Geller; Malak Kotb
Differential regulation of methionine adenosyltransferase in superantigen and mitogen stimulated human T lymphocytes.
The Journal of biological chemistry 1997;272(25):16040-7.
1997: Maha A El-Demellawy; Rashika El Ridi; N I Guirguis; M Abdel Alim; A Kotby; Malak Kotb
Preferential recognition of human myocardial antigens by T lymphocytes from rheumatic heart disease patients.
Infection and immunity 1997;65(6):2197-205.
1997: Bruce Giantonio; R Katherine Alpaugh; J Schultz; Cecilia McAleer; Duane W Newton; B Shannon; Y Guedez; Malak Kotb; L Vitek; Robert Persson; Per Olov Gunnarsson; T Kalland; M Dohlsten; B Persson; Louis M Weiner
Superantigen-based immunotherapy: a phase I trial of PNU-214565, a monoclonal antibody-staphylococcal enterotoxin A recombinant fusion protein, in advanced pancreatic and colorectal cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1997;15(5):1994-2007.
1997: Malak Kotb; W Russel; M Ohman; Donna Hathaway; A Osama Gaber
Clinical implications of flow cytometry B cell crossmatching in renal transplantation.
Transplantation proceedings 1997;29(1-2):1430-2.
1997: Malak Kotb; A Lobashevsky; Y Guedez; A Osama Gaber
Evidence for V beta restricted recognition of HLA-DR alleles.
Transplantation proceedings 1997;29(1-2):1005-7.
1997: Malak Kotb; S Harvey Mudd; José M Mato; AM Geller; N M Kredich; Janice Yang Chou; G L Cantoni
Consensus nomenclature for the mammalian methionine adenosyltransferase genes and gene products.
Trends in genetics : TIG 1997;13(2):51-2.
1997: Anna Norrby-Teglund; Donald E Low; Allison McGeer; Malak Kotb
Superantigenic activity produced by group A streptococcal isolates is neutralized by plasma from IVIG-treated streptococcal toxic shock syndrome patients.
Advances in experimental medicine and biology 1997;418():563-6.
1997: Duane W Newton; Anna Norrby-Teglund; Allison McGeer; Donald E Low; P M Schlievert; Malak Kotb
Novel superantigens from streptococcal toxic shock syndrome Streptococcus pyogenes isolates.
Advances in experimental medicine and biology 1997;418():525-9.
1996: Anna Norrby-Teglund; R Kaul; Donald E Low; Allison McGeer; J Andersson; U Andersson; Malak Kotb
Evidence for the presence of streptococcal-superantigen-neutralizing antibodies in normal polyspecific immunoglobulin G.
Infection and immunity 1996;64(12):5395-8.
1996: A Lobashevsky; Malak Kotb; A Osama Gaber
Selective T cell receptor Vbeta gene usage by alloreactive T cells responding to defined HLA-DR alleles.
Transplantation 1996;62(9):1332-40.
1996: Duane W Newton; M Dohlsten; C Olsson; S Segrén; K E Lundin; PA Lando; T Kalland; Malak Kotb
Mutations in the MHC class II binding domains of staphylococcal enterotoxin A differentially affect T cell receptor Vbeta specificity.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(9):3988-94.
1996: PA Lando; C Olsson; T Kalland; Duane W Newton; Malak Kotb; M Dohlsten
Regulation of superantigen-induced T cell activation in the absence and the presence of MHC class II.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(7):2857-63.
1996: E Baharav; H Gur; Pnina Fishman; Lea Ziporen; Miri Blank; J Aelion; Malak Kotb; Yehuda Shoenfeld
Superantigens and experimental SLE induced by idiotypic dysregulation.
Clinical and experimental rheumatology 1996;14(4):359-66.
1996: C B Hughes; A B el-Din; Malak Kotb; Lillian W Gaber; A Osama Gaber
Calcium channel blockade inhibits release of TNF alpha and improves survival in a rat model of acute pancreatitis.
Pancreas 1996;13(1):22-8.
1996: Anna Norrby-Teglund; R Kaul; Donald E Low; Allison McGeer; Duane W Newton; J Andersson; U Andersson; Malak Kotb
Plasma from patients with severe invasive group A streptococcal infections treated with normal polyspecific IgG inhibits streptococcal superantigen-induced T cell proliferation and cytokine production.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(8):3057-64.
1996: C B Hughes; Hani P Grewal; Lillian W Gaber; Malak Kotb; A B El-din; L Mann; A Osama Gaber
Anti-TNFalpha therapy improves survival and ameliorates the pathophysiologic sequelae in acute pancreatitis in the rat.
American journal of surgery 1996;171(2):274-80.
1996: C B Hughes; Lillian W Gaber; A B Mohey el-Din; Hani P Grewal; Malak Kotb; L Mann; A Osama Gaber
Inhibition of TNF alpha improves survival in an experimental model of acute pancreatitis.
The American surgeon 1996;62(1):8-13.
1995: C B Hughes; J Henry; Malak Kotb; A Lobaschevsky; Omaima Sabek; A Osama Gaber
Up-regulation of TNF alpha mRNA in the rat spleen following induction of acute pancreatitis.
The Journal of surgical research 1995;59(6):687-93.
1995: Donald Y M Leung; J B Travers; R Giorno; D A Norris; R Skinner; J Aelion; L V Kazemi; M H Kim; AE Trumble; Malak Kotb
Evidence for a streptococcal superantigen-driven process in acute guttate psoriasis.
The Journal of clinical investigation 1995;96(5):2106-12.
1995: J De La Rosa; J Ostrowski; M M Hryniewicz; N M Kredich; Malak Kotb; HL LeGros; M Valentine; AM Geller
Chromosomal localization and catalytic properties of the recombinant alpha subunit of human lymphocyte methionine adenosyltransferase.
The Journal of biological chemistry 1995;270(37):21860-8.
1995: Malak Kotb
Bacterial pyrogenic exotoxins as superantigens.
Clinical microbiology reviews 1995;8(3):411-26.
1995: H Ohnishi; J A Ledbetter; S B Kanner; P S Linsley; T Tanaka; AM Geller; Malak Kotb
CD28 cross-linking augments TCR-mediated signals and costimulates superantigen responses.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(7):3180-93.
1995: Malak Kotb; A Lobashevsky; Y Guedez; HL LeGros; J Henry; Omaima Sabek; A Osama Gaber
Restricted V beta usage by alloreactive T cells responding to specific HLA-DR alleles.
Transplantation proceedings 1995;27(1):477-9.
1995: C B Hughes; Lillian W Gaber; Malak Kotb; A B Mohey el-Din; M Pabst; A Osama Gaber
Induction of acute pancreatitis in germ-free rats: evidence of a primary role for tumor necrosis factor-alpha.
Surgery 1995;117(2):201-5.
1995: Lillian W Gaber; L Mann; C Hughes; Malak Kotb; Hosein Shokouh-Amiri; Santiago R Vera; A Osama Gaber
Patterns of expression of endothelial leukocyte adhesion molecules upon revascularization of transplanted kidneys in correlation with allograft pathology.
Transplantation proceedings 1995;27(1):1003-4.
1995: R Watanabe-Ohnishi; Donald E Low; Allison McGeer; D L Stevens; P M Schlievert; Duane W Newton; B Schwartz; B Kreiswirth; Malak Kotb
Selective depletion of V beta-bearing T cells in patients with severe invasive group A streptococcal infections and streptococcal toxic shock syndrome. Ontario Streptococcal Study Project.
The Journal of infectious diseases 1995;171(1):74-84.
1994: B Langkamp-Henken; AM Geller; HL LeGros; J O Price; J De la Rosa; Malak Kotb
Characterization of distinct forms of methionine adenosyltransferase in nucleated, and mature human erythrocytes and erythroleukemic cells.
Biochimica et biophysica acta 1994;1201(3):397-404.
1994: Anna Norrby-Teglund; Duane W Newton; Malak Kotb; Stig E Holm; Mari Norgren
Superantigenic properties of the group A streptococcal exotoxin SpeF (MF).
Infection and immunity 1994;62(12):5227-33.
1994: R Alloway; Malak Kotb; Donna Hathaway; M Ohman; S Strain; A Osama Gaber
The pharmacokinetic profile of standard and low-dose OKT3 induction immunosuppression in renal transplant recipients.
Transplantation 1994;58(2):249-53.
1994: R Watanabe-Ohnishi; J Aelion; Leighton H Legros; M A Tomai; E V Sokurenko; Duane W Newton; J Takahara; S Irino; S Rashed; Malak Kotb
Characterization of unique human TCR V beta specificities for a family of streptococcal superantigens represented by rheumatogenic serotypes of M protein.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(4):2066-73.
1994: Hani P Grewal; Malak Kotb; A M el Din; M Ohman; A Salem; Lillian W Gaber; A Osama Gaber
Induction of tumor necrosis factor in severe acute pancreatitis and its subsequent reduction after hepatic passage.
Surgery 1994;115(2):213-21.
1994: Hani P Grewal; A Mohey el Din; Lillian W Gaber; Malak Kotb; A Osama Gaber
Amelioration of the physiologic and biochemical changes of acute pancreatitis using an anti-TNF-alpha polyclonal antibody.
American journal of surgery 1994;167(1):214-8; discussion 218-9.
1993: Malak Kotb; R Watanabe-Ohnishi; J Aelion; T Tanaka; AM Geller; H Ohnishi
Preservation of the specificity of superantigen to T cell receptor V beta elements in the absence of MHC class II molecules.
Cellular immunology 1993;152(2):348-57.
1993: B Wang; P M Schlievert; A O Gaber; Malak Kotb
Localization of an immunologically functional region of the streptococcal superantigen pepsin-extracted fragment of type 5 M protein.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(3):1419-29.
1993: Malak Kotb; AM Geller
Methionine adenosyltransferase: structure and function.
Pharmacology & therapeutics 1993;59(2):125-43.
1993: R Alloway; Malak Kotb; Donna Hathaway; Lillian W Gaber; Santiago R Vera; A Osama Gaber
Randomized double-blind study of standard versus low-dose OKT3 induction therapy in renal allograft recipients.
American journal of kidney diseases : the official journal of the National Kidney Foundation 1993;22(1):36-43.
1993: R Alloway; Malak Kotb; Donna Hathaway; Lillian W Gaber; Santiago R Vera; A Osama Gaber
Results of a prospective, randomized double-blind study comparing standard vs low-dose OKT3 induction therapy.
Transplantation proceedings 1993;25(1 Pt 1):550-2.
1993: G Majumdar; H Ohnishi; M A Tomai; AM Geller; B Wang; M E Dockter; Malak Kotb
Role of antigen-presenting cells in activation of human T cells by the streptococcal M protein superantigen: requirement for secreted and membrane-associated costimulatory factors.
Infection and immunity 1993;61(2):785-90.
1993: Hani P Grewal; Malak Kotb; A Salem; A B el Din; K Novak; J Martin; Lillian W Gaber; A Osama Gaber
Elevated tumor necrosis factor levels are predictive for pancreas allograft transplant rejection.
Transplantation proceedings 1993;25(1 Pt 1):132-5.
1992: J De La Rosa; AM Geller; HL LeGros; Malak Kotb
Induction of interleukin 2 production but not methionine adenosyltransferase activity or S-adenosylmethionine turnover in Jurkat T-cells.
Cancer research 1992;52(12):3361-6.
1992: J De La Rosa; HL LeGros; AM Geller; Malak Kotb
Changes in the relative amount of subunits of methionine adenosyltransferase in human lymphocytes upon stimulation with a polyclonal T cell mitogen.
The Journal of biological chemistry 1992;267(15):10699-704.
1992: M A Tomai; E H Beachey; G Majumdar; Malak Kotb
Metabolically active antigen presenting cells are required for human T cell proliferation in response to the superantigen streptococcal M protein.
FEMS microbiology immunology 1992;4(3):155-64.
1992: M A Tomai; P M Schlievert; Malak Kotb
Distinct T-cell receptor V beta gene usage by human T lymphocytes stimulated with the streptococcal pyrogenic exotoxins and pep M5 protein.
Infection and immunity 1992;60(2):701-5.
1991: H P Selawry; Malak Kotb; H G Herrod; Z N Lu
Production of a factor, or factors, suppressing IL-2 production and T cell proliferation by Sertoli cell-enriched preparations. A potential role for islet transplantation in an immunologically privileged site.
Transplantation 1991;52(5):846-50.
1991: M A Tomai; J A Aelion; M E Dockter; G Majumdar; D G Spinella; Malak Kotb
T cell receptor V gene usage by human T cells stimulated with the superantigen streptococcal M protein.
The Journal of experimental medicine 1991;174(1):285-8.
1991: J De La Rosa; Malak Kotb; N M Kredich
Regulation of S-adenosylmethionine synthetase activity in cultured human lymphocytes.
Biochimica et biophysica acta 1991;1077(2):225-32.
1990: Malak Kotb; AM Geller; G D Markham; N M Kredich; J De La Rosa; E H Beachey
Antigenic conservation of primary structural regions of S-adenosylmethionine synthetase.
Biochimica et biophysica acta 1990;1040(2):137-44.
1990: Malak Kotb; G Majumdar; M Tomai; E H Beachey
Accessory cell-independent stimulation of human T cells by streptococcal M protein superantigen.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(5):1332-6.
1990: M Tomai; Malak Kotb; G Majumdar; E H Beachey
Superantigenicity of streptococcal M protein.
The Journal of experimental medicine 1990;172(1):359-62.
1990: Malak Kotb; N M Kredich
Regulation of human lymphocyte S-adenosylmethionine synthetase by product inhibition.
Biochimica et biophysica acta 1990;1039(2):253-60.
1990: James B Dale; Harry S Courtney; Malak Kotb; D Schifferli
Phosphorylase-cross-reactive antibodies evoked by streptococcal M protein.
Infection and immunity 1990;58(3):774-8.
1990: G Majumdar; E H Beachey; M Tomai; Malak Kotb
Differential signal requirements in T-cell activation by mitogen and superantigen.
Cellular signalling 1990;2(6):521-30.
1989: AM Geller; Malak Kotb
A binding assay for serine hydroxymethyltransferase.
Analytical biochemistry 1989;180(1):120-5.
1989: Malak Kotb; E H Beachey
Serine and tyrosine phosphorylation of 28- and 35-kDa proteins of human T lymphocytes stimulated by streptococcal M protein.
Biochemical and biophysical research communications 1989;158(3):803-10.
1989: Malak Kotb; Harry S Courtney; James B Dale; E H Beachey
Cellular and biochemical responses of human T lymphocytes stimulated with streptococcal M proteins.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(3):966-70.
1988: AM Geller; Malak Kotb; H M Jernigan; N M Kredich
Methionine adenosyltransferase and S-adenosylmethionine in the developing rat lens.
Experimental eye research 1988;47(2):197-204.
1986: AM Geller; Malak Kotb; H M Jernigan; N M Kredich
Purification and properties of rat lens methionine adenosyltransferase.
Experimental eye research 1986;43(6):997-1008.