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Markku Koulu

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Chemicals & Drugs

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Henriikka Salomäki; Laura H Vähätalo; Kirsti Laurila; Anna-Maija Penttinen; Ullamari Pesonen; Liisa Ailanen; Juan Ilyasizadeh; Norma T Jäppinen; Markku Koulu
Prenatal metformin exposure in mice programs the metabolic phenotype of the offspring during a high fat diet at adulthood.
Hannu Järveläinen; Annele Sainio; Markku Koulu; Thomas N Wight; Risto Penttinen
Extracellular matrix molecules: potential targets in pharmacotherapy.
Suvi T Ruohonen; Ken Abe; Mia Kero; Laura Toukola; Saku Ruohonen; Matias Röyttä; Markku Koulu; Ullamari Pesonen; Zofia Zukowska; Eriika Savontaus
Sympathetic nervous system-targeted neuropeptide Y overexpression in mice enhances neointimal formation in response to vascular injury.

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All Publications

2013: Henriikka Salomäki; Laura H Vähätalo; Kirsti Laurila; Anna-Maija Penttinen; Ullamari Pesonen; Liisa Ailanen; Juan Ilyasizadeh; Norma T Jäppinen; Markku Koulu
Prenatal metformin exposure in mice programs the metabolic phenotype of the offspring during a high fat diet at adulthood.
PloS one 2013;8(2):e56594.
2009: Hannu Järveläinen; Annele Sainio; Markku Koulu; Thomas N Wight; Risto Penttinen
Extracellular matrix molecules: potential targets in pharmacotherapy.
Pharmacological reviews 2009;61(2):198-223.
2009: Suvi T Ruohonen; Ken Abe; Mia Kero; Laura Toukola; Saku Ruohonen; Matias Röyttä; Markku Koulu; Ullamari Pesonen; Zofia Zukowska; Eriika Savontaus
Sympathetic nervous system-targeted neuropeptide Y overexpression in mice enhances neointimal formation in response to vascular injury.
Peptides 2009;30(4):715-20.
2009: Suvi T Ruohonen; Eriika Savontaus; Petteri Rinne; Joana Rosmaninho-Salgado; Claudia Cavadas; Heikki Ruskoaho; Markku Koulu; Ullamari Pesonen
Stress-induced hypertension and increased sympathetic activity in mice overexpressing neuropeptide Y in noradrenergic neurons.
Neuroendocrinology 2009;89(3):351-60.
2008: Suvi T Ruohonen; Ullamari Pesonen; Niko Moritz; Katja Kaipio; Matias Röyttä; Markku Koulu; Eriika Savontaus
Transgenic mice overexpressing neuropeptide Y in noradrenergic neurons: a novel model of increased adiposity and impaired glucose tolerance.
Diabetes 2008;57(6):1517-25.
2007: Ulriikka Jaakkola; Markku Koulu; Matti K Karvonen; H Seppälä; Ullamari Pesonen; Tero Vahlberg; Jaana Kallio
Impact of the Leu7Pro polymorphism of preproNPY on diurnal NPY and hormone secretion in type 2 diabetes.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 2007;115(5):281-6.
2007: Kai Kaarniranta; Juha M Holopainen; Matti K Karvonen; Markku Koulu; Jaana Kallio; Ullamari Pesonen; Markku Teräsvirta; Hannu Uusitalo; Ilkka Immonen
Leucine 7-proline 7 polymorphism in the signal peptide of neuropeptide Y is not a risk factor for exudative age-related macular degeneration.
Acta ophthalmologica Scandinavica 2007;85(2):188-91.
2006: Matti K Karvonen; Soile Ruottinen; Markku Koulu; Ullamari Pesonen; Harri Niinikoski; Leena Rask-Nissilä; Olli Simell; Tapani Rönnemaa
Nutrient intake, weight, and Leu7Pro polymorphism in prepro-neuropeptide Y in children.
The Journal of clinical endocrinology and metabolism 2006;91(11):4664-8.
2006: Ulriikka Jaakkola; Ullamari Pesonen; Elina Vainio-Jylhä; Markku Koulu; M Pöllönen; Jaana Kallio
The Leu7Pro polymorphism of neuropeptide Y is associated with younger age of onset of type 2 diabetes mellitus and increased risk for nephropathy in subjects with diabetic retinopathy.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 2006;114(4):147-52.
2006: Pekka Kääpä; Johanna Pelliniemi; Anne Puuronen; Markku Koulu; Riitta Pyykkö
[Not Available].
Duodecim; lääketieteellinen aikakauskirja 2006;122(18):2233-7.
2005: Ulriikka Jaakkola; Tom A Kuusela; Tuomas Jartti; Ullamari Pesonen; Markku Koulu; Tero Vahlberg; Jaana Kallio
The Leu7Pro polymorphism of preproNPY is associated with decreased insulin secretion, delayed ghrelin suppression, and increased cardiovascular responsiveness to norepinephrine during oral glucose tolerance test.
The Journal of clinical endocrinology and metabolism 2005;90(6):3646-52.
2005: Antti Perheentupa; Risto Erkkola; Markku Koulu
[Primary dysmenorrhea painful menstruation].
Duodecim; lääketieteellinen aikakauskirja 2005;121(13):1411-8.
2004: Anna-Mari Heikkinen; Leo Niskanen; Jukka A Salmi; Markku Koulu; Ullamari Pesonen; M I J Uusitupa; Marja Komulainen; Marjo Tuppurainen; Heikki Kröger; Jukka S Jurvelin; Seppo Saarikoski
Leucine7 to proline7 polymorphism in prepro-NPY gene and femoral neck bone mineral density in postmenopausal women.
Bone 2004;35(3):589-94.
2004: Maarit Hakanen; Tapani Rönnemaa; Sanna Talvia; Leena Rask-Nissilä; Markku Koulu; Jorma Viikari; Matti Bergendahl; Olli Simell
Serum leptin concentration poorly reflects growth and energy and nutrient intake in young children.
Pediatrics 2004;113(5):1273-8.
2004: Kim Pettersson-Fernholm; Matti K Karvonen; Jaana Kallio; Carol Forsblom; Markku Koulu; Ullamari Pesonen; Johan Fagerudd; Per-Henrik Groop
Leucine 7 to proline 7 polymorphism in the preproneuropeptide Y is associated with proteinuria, coronary heart disease, and glycemic control in type 1 diabetic patients.
Diabetes care 2004;27(2):503-9.
2004: Markku Koulu; Sharareh Movafagh; Jukka Tuohimaa; Ulriikka Jaakkola; Jaana Kallio; Ullamari Pesonen; Yixun Geng; Matti K Karvonen; Elina Vainio-Jylhä; Matti Pöllönen; Katja Kaipio-Salmi; Helena Seppälä; Edward W Lee; Rosemary D Higgins; Zofia Zukowska
Neuropeptide Y and Y2-receptor are involved in development of diabetic retinopathy and retinal neovascularization.
Annals of medicine 2004;36(3):232-40.
2003: Jukka Kero; Eriika Savontaus; Maarit Mikola; Ullamari Pesonen; Markku Koulu; Ruth A Keri; John H Nilson; Matti Poutanen; Ilpo T Huhtaniemi
Obesity in transgenic female mice with constitutively elevated luteinizing hormone secretion.
American journal of physiology. Endocrinology and metabolism 2003;285(4):E812-8.
2003: Jaana Kallio; Ullamari Pesonen; Ulriikka Jaakkola; Matti K Karvonen; Hans Helenius; Markku Koulu
Changes in diurnal sympathoadrenal balance and pituitary hormone secretion in subjects with Leu7Pro polymorphism in the prepro-neuropeptide Y.
The Journal of clinical endocrinology and metabolism 2003;88(7):3278-83.
2003: Mikko J Järvisalo; Laura Jartti; Matti K Karvonen; Ullamari Pesonen; Markku Koulu; Jukka Marniemi; Niklas Hammar; Jaakko Kaprio; Ulla Paakkunainen; Olli Simell; Olli T Raitakari; Tapani Rönnemaa
Enhanced endothelium-dependent vasodilation in subjects with Proline7 substitution in the signal peptide of neuropeptide Y.
Atherosclerosis 2003;167(2):319-26.
2002: Moonseong Heo; Rudolph L Leibel; Kevin R Fontaine; Bert Boyer; Wendy Chung; Markku Koulu; Matti K Karvonen; Ullamari Pesonen; Aila Rissanen; M Laakso; M I J Uusitupa; Y Chagnon; C Bouchard; Patricia A Donohoue; T L Burns; Alan R Shuldiner; Kristi D Silver; Ross E Andersen; O Pedersen; Søren M Echwald; Thorkild I A Sørensen; PS Behn; M A Permutt; K B Jacobs; R C Elston; D J Hoffman; E Gropp; David Allison
A meta-analytic investigation of linkage and association of common leptin receptor (LEPR) polymorphisms with body mass index and waist circumference.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2002;26(5):640-6.
2002: Ursula S Schwab; Jyrki J Agren; RH Valve; Merja Hallikainen; Essi S Sarkkinen; M Jauhiainen; Matti K Karvonen; Ullamari Pesonen; Markku Koulu; M I J Uusitupa; Markku Savolainen
The impact of the leucine 7 to proline 7 polymorphism of the neuropeptide Y gene on postprandial lipemia and on the response of serum total and lipoprotein lipids to a reduced fat diet.
European journal of clinical nutrition 2002;56(2):149-56.
2001: Moonseong Heo; Rudolph L Leibel; Bert Boyer; Wendy Chung; Markku Koulu; Matti K Karvonen; Ullamari Pesonen; Aila Rissanen; M Laakso; M I J Uusitupa; Y Chagnon; C Bouchard; Patricia A Donohoue; T L Burns; Alan R Shuldiner; Kristi D Silver; Ross E Andersen; O Pedersen; Søren M Echwald; Thorkild I A Sørensen; PS Behn; M A Permutt; K B Jacobs; R C Elston; D J Hoffman; David Allison
Pooling analysis of genetic data: the association of leptin receptor (LEPR) polymorphisms with variables related to human adiposity.
Genetics 2001;159(3):1163-78.
2001: Jaana Kallio; Ullamari Pesonen; Matti K Karvonen; M Kojima; H Hosoda; K Kangawa; Markku Koulu
Enhanced exercise-induced GH secretion in subjects with Pro7 substitution in the prepro-NPY.
The Journal of clinical endocrinology and metabolism 2001;86(11):5348-52.
2001: Matti K Karvonen; Veli-Pekka Valkonen; Timo A Lakka; Riitta Salonen; Markku Koulu; Ullamari Pesonen; Tomi-Pekka Tuomainen; Jussi Kauhanen; Kristiina Nyyssönen; Hanna-Maaria Lakka; M I J Uusitupa; Jukka T Salonen
Leucine7 to proline7 polymorphism in the preproneuropeptide Y is associated with the progression of carotid atherosclerosis, blood pressure and serum lipids in Finnish men.
Atherosclerosis 2001;159(1):145-51.
2001: Amir Snapir; Petri Heinonen; Tomi-Pekka Tuomainen; P Alhopuro; Matti K Karvonen; Timo A Lakka; Kristiina Nyyssönen; Riitta Salonen; Jussi Kauhanen; Veli-Pekka Valkonen; Ullamari Pesonen; Markku Koulu; Mika Scheinin; Jukka T Salonen
An insertion/deletion polymorphism in the alpha2B-adrenergic receptor gene is a novel genetic risk factor for acute coronary events.
Journal of the American College of Cardiology 2001;37(6):1516-22.
2001: Jaana Kallio; Ullamari Pesonen; K Kaipio; Matti K Karvonen; Ulriikka Jaakkola; Olli Heinonen; M I J Uusitupa; Markku Koulu
Altered intracellular processing and release of neuropeptide Y due to leucine 7 to proline 7 polymorphism in the signal peptide of preproneuropeptide Y in humans.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(7):1242-4.
2001: V Luukkaa; Eriika Savontaus; Juha Rouru; Kirsi A Virtanen; Olivier Boss; Ilpo Huhtaniemi; Markku Koulu; Ullamari Pesonen; Risto Huupponen
Effects of estrous cycle and steroid replacement on the expression of leptin and uncoupling proteins in adipose tissue in the rat.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 2001;15(2):103-12.
2000: Jussi Kauhanen; Matti K Karvonen; Ullamari Pesonen; Markku Koulu; Tomi-Pekka Tuomainen; M I J Uusitupa; Jukka T Salonen
Neuropeptide Y polymorphism and alcohol consumption in middle-aged men.
American journal of medical genetics 2000;93(2):117-21.
2000: Jari Tiihonen; Ullamari Pesonen; Jussi Kauhanen; Markku Koulu; Tero Hallikainen; L Leskinen; Jukka T Salonen
CYP2A6 genotype and smoking.
Molecular psychiatry 2000;5(4):347-8.
2000: Seppo Helisalmi; RH Valve; Matti K Karvonen; Mikko Hiltunen; Mia Pirskanen; Arto Mannermaa; Markku Koulu; Ullamari Pesonen; Matti Uusitupa; Hilkka Soininen
The leucine (7)-to-proline (7) polymorphism in the signal peptide of neuropeptide Y is not associated with Alzheimer's disease or the link apolipoprotein E.
Neuroscience letters 2000;287(1):25-8.
2000: Tero Hallikainen; Herbert M Lachman; T Saito; Jan Volavka; Jussi Kauhanen; Jukka T Salonen; Olli-Pekka Ryynänen; Markku Koulu; Matti K Karvonen; Tiina Pohjalainen; Erkka Syvälahti; Jarmo Hietala; Jari Tiihonen
Lack of association between the functional variant of the catechol-o-methyltransferase (COMT) gene and early-onset alcoholism associated with severe antisocial behavior.
American journal of medical genetics 2000;96(3):348-52.
2000: Leo Niskanen; Matti K Karvonen; RH Valve; Markku Koulu; Ullamari Pesonen; M Mercuri; Rainer Rauramaa; Jari Töyry; Markku Laakso; M I J Uusitupa
Leucine 7 to proline 7 polymorphism in the neuropeptide Y gene is associated with enhanced carotid atherosclerosis in elderly patients with type 2 diabetes and control subjects.
The Journal of clinical endocrinology and metabolism 2000;85(6):2266-9.
2000: Matti K Karvonen; Markku Koulu; Ullamari Pesonen; M I J Uusitupa; Anne Tammi; Jorma Viikari; Olli Simell; Tapani Rönnemaa
Leucine 7 to proline 7 polymorphism in the preproneuropeptide Y is associated with birth weight and serum triglyceride concentration in preschool aged children.
The Journal of clinical endocrinology and metabolism 2000;85(4):1455-60.
2000: Eriika Savontaus; Juha Rouru; Kimmo Malminiemi; V Luukkaa; Ullamari Pesonen; Markku Koulu; Risto Huupponen
Effects of chronic celiprolol treatment on brown fat, feeding, and drinking in fa/fa Zucker rats.
Pharmacology, biochemistry, and behavior 2000;65(4):719-24.
2000: Jussi Kauhanen; Tero Hallikainen; Tomi-Pekka Tuomainen; Markku Koulu; Matti K Karvonen; Jukka T Salonen; Jari Tiihonen
Association between the functional polymorphism of catechol-O-methyltransferase gene and alcohol consumption among social drinkers.
Alcoholism, clinical and experimental research 2000;24(2):135-9.
2000: Leo Niskanen; Raija Voutilainen-Kaunisto; Markku Teräsvirta; Matti K Karvonen; RH Valve; Ullamari Pesonen; Markku Laakso; M I J Uusitupa; Markku Koulu
Leucine 7 to proline 7 polymorphism in the neuropeptide y gene is associated with retinopathy in type 2 diabetes.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 2000;108(3):235-6.
1999: Petri Heinonen; Markku Koulu; Ullamari Pesonen; Matti K Karvonen; Aila Rissanen; Markku Laakso; RH Valve; Matti Uusitupa; Mika Scheinin
Identification of a three-amino acid deletion in the alpha2B-adrenergic receptor that is associated with reduced basal metabolic rate in obese subjects.
The Journal of clinical endocrinology and metabolism 1999;84(7):2429-33.
1999: Jari Tiihonen; Tero Hallikainen; Herbert M Lachman; T Saito; Jan Volavka; Jussi Kauhanen; Jukka T Salonen; Olli-Pekka Ryynänen; Markku Koulu; Matti K Karvonen; Tiina Pohjalainen; Erkka Syvälahti; Jarmo Hietala
Association between the functional variant of the catechol-O-methyltransferase (COMT) gene and type 1 alcoholism.
Molecular psychiatry 1999;4(3):286-9.
1999: M I Uusitupa; M K Karvonen; Ullamari Pesonen; Markku Koulu
[Neuropeptide Y and serum cholesterol].
Duodecim; lääketieteellinen aikakauskirja 1999;115(3):241-2.
1998: M I Uusitupa; Matti K Karvonen; Ullamari Pesonen; Markku Koulu
Neuropeptide Y: a novel link between the neuroendocrine system and cholesterol metabolism.
Annals of medicine 1998;30(6):508-10.
1998: Matti K Karvonen; Ullamari Pesonen; Markku Koulu; L Niskanen; M Laakso; Aila Rissanen; J M Dekker; L M Hart; RH Valve; M I J Uusitupa
Association of a leucine(7)-to-proline(7) polymorphism in the signal peptide of neuropeptide Y with high serum cholesterol and LDL cholesterol levels.
Nature medicine 1998;4(12):1434-7.
1998: V Luukkaa; Ullamari Pesonen; Ilpo Huhtaniemi; A Lehtonen; R Tilvis; Jaakko Tuomilehto; Markku Koulu; Risto Huupponen
Inverse correlation between serum testosterone and leptin in men.
The Journal of clinical endocrinology and metabolism 1998;83(9):3243-6.
1998: Matti K Karvonen; Ullamari Pesonen; Petri Heinonen; Markku Laakso; Aila Rissanen; Hannu Naukkarinen; RH Valve; M I J Uusitupa; Markku Koulu
Identification of new sequence variants in the leptin gene.
The Journal of clinical endocrinology and metabolism 1998;83(9):3239-42.
1998: T Teirmaa; V Luukkaa; Juha Rouru; Markku Koulu; Risto Huupponen
Correlation between circulating leptin and luteinizing hormone during the menstrual cycle in normal-weight women.
European journal of endocrinology / European Federation of Endocrine Societies 1998;139(2):190-4.
1998: Eriika Savontaus; Juha Rouru; Olivier Boss; Risto Huupponen; Markku Koulu
Differential regulation of uncoupling proteins by chronic treatments with beta 3-adrenergic agonist BRL 35135 and metformin in obese fa/fa Zucker rats.
Biochemical and biophysical research communications 1998;246(3):899-904.
1998: Eriika Savontaus; Ullamari Pesonen; Juha Rouru; Risto Huupponen; Markku Koulu
Effects of ZD7114, a selective beta3-adrenoceptor agonist, on neuroendocrine mechanisms controlling energy balance.
European journal of pharmacology 1998;347(2-3):265-74.
1998: Ullamari Pesonen; Markku Koulu; A Bergen; M Eggert; Hannu Naukkarinen; Matti Virkkunen; Markku Linnoila; David Goldman
Mutation screening of the 5-hydroxytryptamine7 receptor gene among Finnish alcoholics and controls.
Psychiatry research 1998;77(3):139-45.
1998: Mika Scheinin; A Illi; Markku Koulu; P Ojala-Karlsson
Norepinephrine metabolites in plasma as indicators of pharmacological inhibition of monoamine oxidase and catechol O-methyltransferase.
Advances in pharmacology (San Diego, Calif.) 1998;42():367-70.
1997: Kirsi A Virtanen; Juha Rouru; V Hänninen; Eriika Savontaus; T Rouvari; T Teirmaa; Markku Koulu; Risto Huupponen
Chronic treatment with BRL 35135 potentiates the action of insulin on lipid metabolism.
European journal of pharmacology 1997;332(2):215-8.
1997: Eriika Savontaus; A Raasmaja; Juha Rouru; Markku Koulu; Ullamari Pesonen; Raine Virtanen; Juha-Matti Savola; Risto Huupponen
Anti-obesity effect of MPV-1743 A III, a novel imidazoline derivative, in genetic obesity.
European journal of pharmacology 1997;328(2-3):207-15.
1997: Juha Rouru; Leena Anttila; P Koskinen; TA Penttilä; Kerttu Irjala; Risto Huupponen; Markku Koulu
Serum leptin concentrations in women with polycystic ovary syndrome.
The Journal of clinical endocrinology and metabolism 1997;82(6):1697-700.
1996: T Keränen; Ariel Gordin; Markku Koulu; Mika Scheinin; Saila Antila; S Sundberg; T Wikberg
COMT inhibition by entacapone does not affect growth hormone or prolactin secretion in healthy volunteers.
Journal of neural transmission (Vienna, Austria : 1996) 1996;103(6):729-36.
1995: Juha Rouru; Markku Koulu; Juha Peltonen; E Santti; V Hänninen; Ullamari Pesonen; Risto Huupponen
Effects of metformin treatment on glucose transporter proteins in subcellular fractions of skeletal muscle in (fa/fa) Zucker rats.
British journal of pharmacology 1995;115(7):1182-7.
1995: Juha Rouru; Ullamari Pesonen; Markku Koulu; Risto Huupponen; E Santti; K Virtanen; T Rouvari; M Jhanwar-Uniyal
Anorectic effect of metformin in obese Zucker rats: lack of evidence for the involvement of neuropeptide Y.
European journal of pharmacology 1995;273(1-2):99-106.
1994: E Santti; Risto Huupponen; Juha Rouru; V Hänninen; Ullamari Pesonen; M Jhanwar-Uniyal; Markku Koulu
Potentiation of the anti-obesity effect of the selective beta 3-adrenoceptor agonist BRL 35135 in obese Zucker rats by exercise.
British journal of pharmacology 1994;113(4):1231-6.
1994: A Illi; S Sundberg; Markku Koulu; Mika Scheinin; S Heinävaara; Ariel Gordin
COMT inhibition by high-dose entacapone does not affect hemodynamics but changes catecholamine metabolism in healthy volunteers at rest and during exercise.
International journal of clinical pharmacology and therapeutics 1994;32(11):582-8.
1994: E Santti; T Rouvari; Juha Rouru; Risto Huupponen; Markku Koulu
Effect of chronic treatment with ICI D7114, a selective beta 3-adrenoceptor agonist, on macronutrient selection and brown adipose tissue thermogenesis in Sprague-Dawley rats.
Pharmacology & toxicology 1994;75(3-4):166-9.
1994: Oskari Heikinheimo; Ullamari Pesonen; R Huupponen; Markku Koulu; Pekka Lähteenmäki
Hepatic metabolism and distribution of mifepristone and its metabolites in rats.
Human reproduction (Oxford, England) 1994;9 Suppl 1():40-6.
1994: Ullamari Pesonen; Markku Koulu
[Brain neurochemical systems which control appetite].
Duodecim; lääketieteellinen aikakauskirja 1994;110(13):1241-50.
1993: Juha Rouru; K Isaksson; E Santti; Risto Huupponen; Markku Koulu
Metformin and brown adipose tissue thermogenetic activity in genetically obese Zucker rats.
European journal of pharmacology 1993;246(1):67-71.
1993: Juha Rouru; Ullamari Pesonen; K Isaksson; Risto Huupponen; Markku Koulu
Effect of chronic treatment with TFMPP, a 5-HT1 receptor agonist, on food intake, weight gain, plasma insulin and neuropeptide mRNA expression in obese Zucker rats.
European journal of pharmacology 1993;234(2-3):191-8.
1993: Juha Rouru; Risto Huupponen; E Santti; Markku Koulu
Effect of subchronic metformin treatment on macronutrient selection in genetically obese Zucker rats.
Pharmacology & toxicology 1993;72(4-5):300-3.
1993: Markku Koulu; Ullamari Pesonen; S Koskinen; Harry Scheinin; Raine Virtanen; Mika Scheinin
Reduced turnover of dopamine and 5-hydroxytryptamine in discrete dopaminergic, noradrenergic and serotonergic rat brain areas after acutely administered medetomidine, a selective alpha 2-adrenoceptor agonist.
Pharmacology & toxicology 1993;72(3):182-7.
1993: Risto Huupponen; K Pyykkö; Markku Koulu; Juha Rouru
Metformin and liver glycogen synthase activity in obese Zucker rats.
Research communications in chemical pathology and pharmacology 1993;79(2):219-27.
1992: Risto Huupponen; P Ojala-Karlsson; Juha Rouru; Markku Koulu
Determination of metformin in plasma by high-performance liquid chromatography.
Journal of chromatography 1992;583(2):270-3.
1992: Ullamari Pesonen; Risto Huupponen; Juha Rouru; Markku Koulu
Hypothalamic neuropeptide expression after food restriction in Zucker rats: evidence of persistent neuropeptide Y gene activation.
Brain research. Molecular brain research 1992;16(3-4):255-60.
1992: Jarmo Hietala; Markku Koulu; M Kuoppamäki; J Lappalainen; Erkka Syvälahti
Chronic clozapine treatment down-regulates serotonin 5-HT-1c receptors in rat brain.
Progress in neuro-psychopharmacology & biological psychiatry 1992;16(5):727-32.
1992: Ullamari Pesonen; J Jolkkonen; Risto Huupponen; Markku Koulu
Differential hypothalamic arginine vasopressin response to glucocorticoid receptor antagonism in lean and obese Zucker rats.
Neuroendocrinology 1992;56(2):271-7.
1992: Ullamari Pesonen; T Miettinen; Mika Scheinin; Markku Koulu
Alpha 2-adrenoceptor density in forebrain areas of Zucker rats: no effect of genetic obesity or antiglucocorticoid treatment.
Brain research 1992;574(1-2):353-6.
1992: Ullamari Pesonen; Markku Koulu; Oskari Heikinheimo; Risto Huupponen
The glucocorticoid antagonist mifepristone reveals abnormal regulation of the adrenocortical system in obese Zucker rats.
The Journal of endocrinology 1992;132(3):425-31.
1992: Juha Rouru; Risto Huupponen; Ullamari Pesonen; Markku Koulu
Subchronic treatment with metformin produces anorectic effect and reduces hyperinsulinemia in genetically obese Zucker rats.
Life sciences 1992;50(23):1813-20.
1991: Ullamari Pesonen; Juha Rouru; Risto Huupponen; Markku Koulu
Effects of repeated administration of mifepristone and 8-OH-DPAT on expression of preproneuropeptide Y mRNA in the arcuate nucleus of obese Zucker rats.
Brain research. Molecular brain research 1991;10(3):267-72.
1991: Esa R Korpi; P Päivärinta; B Sjöholm; Markku Koulu
Hypothalamic monoamines and food intake in alcohol-preferring AA and alcohol-avoiding ANA rats.
Alcohol (Fayetteville, N.Y.) 1991;8(2):137-41.
1991: M A Päivärinta; Reijo J Marttila; Markku Koulu; Ullamari Pesonen; Matias Röyttä; UK Rinne
Brain monoamine metabolism and rotational behaviour induced by experimental herpes simplex virus encephalitis.
Journal of neural transmission. General section 1991;86(3):181-90.
1991: J Lappalainen; Jarmo Hietala; Markku Koulu; B Sjöholm; Erkka Syvälahti
Effects of acute administration of SCH 23390 on dopamine and serotonin turnover in major dopaminergic areas and mesencephalic raphe nuclei--comparison with ritanserin.
Progress in neuro-psychopharmacology & biological psychiatry 1991;15(6):861-72.
1991: Mika Scheinin; S Karhuvaara; P Ojala-Karlsson; A Kallio; Markku Koulu
Plasma 3,4-dihydroxyphenylglycol (DHPG) and 3-methoxy-4-hydroxyphenylglycol (MHPG) are insensitive indicators of alpha 2-adrenoceptor mediated regulation of norepinephrine release in healthy human volunteers.
Life sciences 1991;49(1):75-84.
1990: Risto Huupponen; Markku Koulu; Ullamari Pesonen
Hypothalamic 5-hydroxytryptamine metabolism is not influenced by streptozotocin-diabetes induced at neonatal age.
Experimental and clinical endocrinology 1990;96(3):328-30.
1990: J Lappalainen; Jarmo Hietala; Markku Koulu; Erkka Syvälahti
Neurochemical effects of chronic co-administration of ritanserin and haloperidol: comparison with clozapine effects.
European journal of pharmacology 1990;190(3):403-7.
1990: Markku Koulu; Risto Huupponen; H Hänninen; Ullamari Pesonen; Juha Rouru; T Seppälä
Hypothalamic neurochemistry and feeding behavioral responses to clonidine, an alpha-2-agonist, and to trifluoromethylphenylpiperazine, a putative 5-hydroxytryptamine-1B agonist, in genetically obese Zucker rats.
Neuroendocrinology 1990;52(5):503-10.
1990: Jarmo Hietala; J Lappalainen; Markku Koulu; Erkka Syvälahti
Dopamine D1 receptor antagonism in schizophrenia: is there reduced risk of extrapyramidal side-effects?
Trends in pharmacological sciences 1990;11(10):406-10.
1990: Markku Koulu; J Lappalainen; Jarmo Hietala; B Sjöholm; Raine Virtanen
5-HT3 receptor antagonist ondansetron does not alter effects of amphetamine on DA metabolism.
Neuroreport 1990;1(2):126-8.
1990: Markku Koulu; Ullamari Pesonen; Raine Virtanen
Chronic dexmedetomidine, a selective alpha 2-agonist, decreases serotonin but not noradrenaline turnover in rat brainstem nuclei.
European journal of pharmacology 1990;176(2):151-7.
1990: J Lappalainen; Jarmo Hietala; Markku Koulu; T Seppälä; B Sjöholm; Erkka Syvälahti
Chronic treatment with SCH 23390 and haloperidol: effects on dopaminergic and serotonergic mechanisms in rat brain.
The Journal of pharmacology and experimental therapeutics 1990;252(2):845-52.
1990: Mika Scheinin; Markku Koulu; O Vakkuri; J Vuorinen; R H Zimmer
Moclobemide, an inhibitor of MAO-A, does not increase daytime plasma melatonin levels in normal humans.
Progress in neuro-psychopharmacology & biological psychiatry 1990;14(1):73-82.
1990: Mika Scheinin; Markku Koulu; S Karhuvaara; R H Zimmer
Evidence that the reversible MAO-A inhibitor moclobemide increases prolactin secretion by a serotonergic mechanism in healthy male volunteers.
Life sciences 1990;47(16):1491-9.
1990: Markku Koulu; J Lappalainen; Jarmo Hietala; B Sjöholm
Effects of chronic administration of ondansetron (GR38032F), a selective 5-HT3 receptor antagonist, on monoamine metabolism in mesolimbic and nigrostriatal dopaminergic neurons and on striatal D2-receptor binding.
Psychopharmacology 1990;101(2):168-71.
1990: S Karhuvaara; A Kallio; Markku Koulu; Harry Scheinin; Mika Scheinin
No involvement of alpha 2-adrenoceptors in the regulation of basal prolactin secretion in healthy men.
Psychoneuroendocrinology 1990;15(2):125-9.
1990: Mika Scheinin; Markku Koulu; E Castrén
[Receptors and mediators in nerve cells].
Duodecim; lääketieteellinen aikakauskirja 1990;106(22):1527-36.
1989: Markku Koulu; B Sjöholm; J Lappalainen; Raine Virtanen
Effects of acute GR38032F (odansetron), a 5-HT3 receptor antagonist, on dopamine and serotonin metabolism in mesolimbic and nigrostriatal dopaminergic neurons.
European journal of pharmacology 1989;169(2-3):321-4.
1989: A Kallio; Mika Scheinin; Markku Koulu; R Ponkilainen; H Ruskoaho; O Viinamäki; Harry Scheinin
Effects of dexmedetomidine, a selective alpha 2-adrenoceptor agonist, on hemodynamic control mechanisms.
Clinical pharmacology and therapeutics 1989;46(1):33-42.
1989: Markku Koulu; Mika Scheinin; A Kaarttinen; Jaana Kallio; K Pyykkö; J Vuorinen; R H Zimmer
Inhibition of monoamine oxidase by moclobemide: effects on monoamine metabolism and secretion of anterior pituitary hormones and cortisol in healthy volunteers.
British journal of clinical pharmacology 1989;27(2):243-55.
1988: Markku Koulu; J Lappalainen; Ullamari Pesonen; Jarmo Hietala; Erkka Syvälahti
Chronic treatment with SCH 23390, a selective dopamine D-1 receptor antagonist, decreases dopamine metabolism in rat caudate nucleus.
European journal of pharmacology 1988;155(3):313-6.
1988: A Kallio; Markku Koulu; Harry Scheinin; J Viikari; Mika Scheinin
Acute effects of medetomidine, a selective alpha 2-adrenoceptor agonist, on anterior pituitary hormone and cortisol secretion in man.
Acta endocrinologica 1988;119(1):11-5.
1988: Risto Huupponen; Markku Koulu; U M Jaakkola
Somatostatin concentrations in discrete hypothalamic nuclei of genetically obese Zucker rats.
Experimental and clinical endocrinology 1988;91(3):277-81.
1987: Mika Scheinin; Markku Koulu; E Laurikainen; H Allonen
Hypokalaemia and other non-bronchial effects of inhaled fenoterol and salbutamol: a placebo-controlled dose-response study in healthy volunteers.
British journal of clinical pharmacology 1987;24(5):645-53.
1987: Mika Scheinin; A Kallio; Markku Koulu; J Viikari; Harry Scheinin
Sedative and cardiovascular effects of medetomidine, a novel selective alpha 2-adrenoceptor agonist, in healthy volunteers.
British journal of clinical pharmacology 1987;24(4):443-51.