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Richard Koup

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Joseph P Casazza; Mary E Enama; Ingelise J Gordon; Emma Gostick; Raphael Gottardo; Barney S Graham; Mary F Kearney; Richard A Koup; Julie E Ledgerwood; Frank M Maldarelli; Martha C Nason; Deborah Persaud; David A Price; Mario Roederer; Emily C Smith; Ann Wiegand; Carrie Ziemniak; Selorm Adzaku; David R Ambrozak; Charla A Andrews; Robert T Bailer; Kathryn A Bowman
Therapeutic Vaccination Expands and Improves the Function of the HIV-Specific Memory T-Cell Repertoire.
Maria H Dominguez; Greg Finak; Raphael Gottardo; Richard A Koup; Laurie Lamoreaux; Steven Ma; Andrew McDavid; Pratip K Chattopadhyay; Mario Roederer
Highly multiplexed quantitation of gene expression on single cells.
Kylie M Quinn; Mario Roederer; Lingshu Wang; Linda S Wyatt; Ayako Yamamoto; Robert T Bailer; Dana Berry; Cheng Cheng; Stefano Colloca; Riccardo Cortese; Andreia Da Costa; Patricia A Darrah; Mariano Esteban; Antonella Folgori; Jason G D Gall; Carmen E Gomez; Emma Gostick; Wing-Pui Kong; Richard A Koup; Ross W B Lindsay; Cecilia Morgan; Bernard Moss; Gary Nabel; Alfredo Nicosia; David A Price; Robert A Seder
Comparative analysis of the magnitude, quality, phenotype, and protective capacity of simian immunodeficiency virus gag-specific CD8+ T cells following human-, simian-, and chimpanzee-derived recombinant adenoviral vector immunization.

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All Publications

2013: Joseph P Casazza; Mary E Enama; Ingelise J Gordon; Emma Gostick; Raphael Gottardo; Barney S Graham; Mary F Kearney; Richard A Koup; Julie E Ledgerwood; Frank M Maldarelli; Martha C Nason; Deborah Persaud; David A Price; Mario Roederer; Emily C Smith; Ann Wiegand; Carrie Ziemniak; Selorm Adzaku; David R Ambrozak; Charla A Andrews; Robert T Bailer; Kathryn A Bowman
Therapeutic Vaccination Expands and Improves the Function of the HIV-Specific Memory T-Cell Repertoire.
The Journal of infectious diseases 2013;207(12):1829-40.
2013: Maria H Dominguez; Greg Finak; Raphael Gottardo; Richard A Koup; Laurie Lamoreaux; Steven Ma; Andrew McDavid; Pratip K Chattopadhyay; Mario Roederer
Highly multiplexed quantitation of gene expression on single cells.
Journal of immunological methods 2013;391(1-2):133-45.
2013: Kylie M Quinn; Mario Roederer; Lingshu Wang; Linda S Wyatt; Ayako Yamamoto; Robert T Bailer; Dana Berry; Cheng Cheng; Stefano Colloca; Riccardo Cortese; Andreia Da Costa; Patricia A Darrah; Mariano Esteban; Antonella Folgori; Jason G D Gall; Carmen E Gomez; Emma Gostick; Wing-Pui Kong; Richard A Koup; Ross W B Lindsay; Cecilia Morgan; Bernard Moss; Gary Nabel; Alfredo Nicosia; David A Price; Robert A Seder
Comparative analysis of the magnitude, quality, phenotype, and protective capacity of simian immunodeficiency virus gag-specific CD8+ T cells following human-, simian-, and chimpanzee-derived recombinant adenoviral vector immunization.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(6):2720-35.
2013: Barney S Graham; Richard A Koup; Julie E Ledgerwood; John R Mascola; Gary Nabel; Martha C Nason; Sheila A Peel; Sarah A Plummer; Mario Roederer; Robert T Bailer; Mary E Enama; Ingelise J Gordon
DNA Vaccine Delivered by a Needle-Free Injection Device Improves Potency of Priming for Antibody and CD8+ T-Cell Responses after rAd5 Boost in a Randomized Clinical Trial.
PloS one 2013;8(4):e59340.
2012: J E Ledgerwood; John R Mascola; Gary Nabel; M B Pearce; S Plummer; T M Tumpey; G Yamshchikov; Robert T Bailer; Mary E Enama; I J Gordon; Barney S Graham; Z Hu; Richard A Koup
Influenza virus h5 DNA vaccination is immunogenic by intramuscular and intradermal routes in humans.
Clinical and vaccine immunology : CVI 2012;19(11):1792-7.
2012: Niklas K Björkström; Frank Cichocki; Richard A Koup; Stella Larsson; Jeffrey Levine; Lisa L Liu; Hans-Gustaf Ljunggren; Stephen K Anderson; Vivien Béziat; Karl-Johan Malmberg
CD8 T cells express randomly selected KIRs with distinct specificities compared with NK cells.
Blood 2012;120(17):3455-65.
2012: Adrian B McDermott; Richard A Koup
CD8(+) T cells in preventing HIV infection and disease.
AIDS (London, England) 2012;26(10):1281-92.
2012: Matthew J Johnson; Mark J Cameron; Jason G D Gall; Emma Gostick; Elias Haddad; François Lefebvre; Ross W B Lindsay; Karin Loré; Constantinos Petrovas; David A Price; Robert A Seder; Rafick-Pierre Sekaly; Takuya Yamamoto; Richard A Koup
Type I IFN induced by adenovirus serotypes 28 and 35 has multiple effects on T cell immunogenicity.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(12):6109-18.
2012: William C Adams; Ronald J Berenson; Gunilla B Karlsson Hedestam; Richard A Koup; André Lieber; Karin Loré
Attenuation of CD4+ T-cell function by human adenovirus type 35 is mediated by the knob protein.
The Journal of general virology 2012;93(Pt 6):1339-44.
2012: Laurie Lamoreaux; Richard A Koup; Mario Roederer
OMIP-009: Characterization of antigen-specific human T-cells.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2012;81(5):362-3.
2012: Christof Geldmacher; Richard A Koup
Pathogen-specific T cell depletion and reactivation of opportunistic pathogens in HIV infection.
Trends in immunology 2012;33(5):207-14.
2012: Loury Janbazian; Richard A Koup; David A Price; Jean-Pierre Routy; Phillip Scheinberg; Rafick-Pierre Sekaly; David R Ambrozak; Tedi E Asher; Mohamed-Rachid Boulassel; Glenda Canderan; Daniel C Douek; Abdelali Filali-Mouhim; Lydie Trautmann
Clonotype and repertoire changes drive the functional improvement of HIV-specific CD8 T cell populations under conditions of limited antigenic stimulation.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(3):1156-67.
2011: Nancy J Sullivan; Gene Garrard Olinger; SRINIVAS RAO; Keith A Reimann; Mario Roederer; Daphne Stanley; Clement Asiedu; Michael Bailey; Saran Bao; Joan B Geisbert; Thomas W Geisbert; Lisa E Hensley; Anna N Honko; Peter B Jahrling; Joshua Johnson; Richard A Koup; Gary Nabel
CD8+ cellular immunity mediates rAd5 vaccine protection against Ebola virus infection of nonhuman primates.
Nature medicine 2011;17(9):1128-31.
2011: Julie E Ledgerwood; Theodore C Pierson; Sarah A Hubka; Niraj Desai; Steve Rucker; Ingelise J Gordon; Mary E Enama; Steevenson Nelson; Martha Nason; Wenjuan Gu; Nikkida Bundrant; Richard A Koup; Robert T Bailer; John R Mascola; Gary Nabel; Barney S Graham
A West Nile virus DNA vaccine utilizing a modified promoter induces neutralizing antibody in younger and older healthy adults in a phase I clinical trial.
The Journal of infectious diseases 2011;203(10):1396-404.
2011: Takuya Yamamoto; David A Price; Joseph P Casazza; Guido Ferrari; Martha Nason; Pratip K Chattopadhyay; Mario Roederer; Emma Gostick; Peter D Katsikis; Daniel C Douek; Richard Haubrich; Constantinos Petrovas; Richard A Koup
Surface expression patterns of negative regulatory molecules identify determinants of virus-specific CD8+ T-cell exhaustion in HIV infection.
Blood 2011;117(18):4805-15.
2011: William C Adams; Cornelia Gujer; Gerald McInerney; Jason G D Gall; Constantinos Petrovas; Gunilla B Karlsson Hedestam; Richard A Koup; Karin Loré
Adenovirus type-35 vectors block human CD4+ T-cell activation via CD46 ligation.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(18):7499-504.
2011: Thomas W Geisbert; Michael Bailey; Lisa E Hensley; Clement Asiedu; Joan B Geisbert; Daphne Stanley; Anna Honko; Joshua Johnson; Sabue Mulangu; Maria G Pau; Jerome H H V Custers; Jort Vellinga; Jenny Hendriks; Peter B Jahrling; Mario Roederer; Jaap Goudsmit; Richard A Koup; Nancy J Sullivan
Recombinant adenovirus serotype 26 (Ad26) and Ad35 vaccine vectors bypass immunity to Ad5 and protect nonhuman primates against ebolavirus challenge.
Journal of virology 2011;85(9):4222-33.
2011: Angela M Minassian; Ansar A Pathan; Ian D Poulton; Hazel Poyntz; David A Price; Mario Roederer; Guy Rooney; Jonathan Ross; Rosalind Rowland; Clare R Sander; Iman Satti; Jackie Sherrard; Nicola Williams; Alan Winston; David R Ambrozak; Natalie E R Beveridge; Joseph P Casazza; Daniel C Douek; Helen A Fletcher; Kristin Griffiths; Matthew Hamill; Stephanie Harris; Brenna J Hill; Richard A Koup; Alison M Lawrie; Helen McShane
A Phase I study evaluating the safety and immunogenicity of MVA85A, a candidate TB vaccine, in HIV-infected adults.
BMJ open 2011;1(2):e000223.
2011: Alexandra Schuetz; Antelmo Haule; Michael Hoelscher; Richard A Koup; Leonard Maboko; Andreas Meyerhans; Njabulo Ngwenyama; Andrea Rachow; Klaus Reither; Christof Geldmacher
Monitoring CD27 expression to evaluate Mycobacterium tuberculosis activity in HIV-1 infected individuals in vivo.
PloS one 2011;6(11):e27284.
2011: David Zarkowsky; Laurie Lamoreaux; Pratip K Chattopadhyay; Richard A Koup; Stephen P Perfetto; Mario Roederer
Heavy metal contaminants can eliminate quantum dot fluorescence.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2011;79(1):84-9.
2011: Richard A Koup; Barney S Graham; Daniel C Douek
The quest for a T cell-based immune correlate of protection against HIV: a story of trials and errors.
Nature reviews. Immunology 2011;11(1):65-70.
2011: Stephen P Perfetto; David R Ambrozak; Richard Nguyen; Mario Roederer; Richard A Koup; Kevin L Holmes
Standard practice for cell sorting in a BSL-3 facility.
Methods in molecular biology (Clifton, N.J.) 2011;699():449-69.
2010: Christof Geldmacher; Njabulo Ngwenyama; Alexandra Schuetz; Constantinos Petrovas; Klaus Reither; Edwin J Heeregrave; Joseph P Casazza; David R Ambrozak; Mark Louder; William Ampofo; Georgios Pollakis; Brenna Hill; Erica Sanga; Elmar Saathoff; Leonard Maboko; Mario Roederer; William A Paxton; Michael Hoelscher; Richard A Koup
Preferential infection and depletion of Mycobacterium tuberculosis-specific CD4 T cells after HIV-1 infection.
The Journal of experimental medicine 2010;207(13):2869-81.
2010: J E Ledgerwood; P Costner; N Desai; L Holman; Mary E Enama; G Yamshchikov; S Mulangu; Z Hu; Charla A Andrews; R A Sheets; Richard A Koup; Mario Roederer; Robert T Bailer; John R Mascola; Maria G Pau; Nancy J Sullivan; Jaap Goudsmit; Gary Nabel; Barney S Graham
A replication defective recombinant Ad5 vaccine expressing Ebola virus GP is safe and immunogenic in healthy adults.
Vaccine 2010;29(2):304-13.
2010: Thomas W Geisbert; Michael Bailey; Joan B Geisbert; Clement Asiedu; Mario Roederer; Maria Grazia-Pau; Jerome H H V Custers; Peter B Jahrling; Jaap Goudsmit; Richard A Koup; Nancy J Sullivan
Vector choice determines immunogenicity and potency of genetic vaccines against Angola Marburg virus in nonhuman primates.
Journal of virology 2010;84(19):10386-94.
2010: Stephen P Perfetto; Pratip K Chattopadhyay; Laurie Lamoreaux; Richard Nguyen; David R Ambrozak; Richard A Koup; Mario Roederer
Amine-reactive dyes for dead cell discrimination in fixed samples.
Current protocols in cytometry / editorial board, J. Paul Robinson, managing editor ... [et al.] 2010;Chapter 9():Unit 9.34.
2010: Richard A Koup; Mario Roederer; Laurie Lamoreaux; Jennifer Fischer; Laura Novik; Martha C Nason; Brenda D Larkin; Mary E Enama; Julie E Ledgerwood; Robert T Bailer; John R Mascola; Gary Nabel; Barney S Graham
Priming immunization with DNA augments immunogenicity of recombinant adenoviral vectors for both HIV-1 specific antibody and T-cell responses.
PloS one 2010;5(2):e9015.
2010: Cheng Cheng; Jason G D Gall; Martha Nason; C Richter King; Richard A Koup; Mario Roederer; M Juliana McElrath; Cecilia A Morgan; Gavin Churchyard; Lindsey R Baden; Ann C Duerr; Michael C Keefer; Barney S Graham; Gary Nabel
Differential specificity and immunogenicity of adenovirus type 5 neutralizing antibodies elicited by natural infection or immunization.
Journal of virology 2010;84(1):630-8.
2009: Jung S Byun; Madeline M Wong; Wenwu Cui; Gila Idelman; Quentin Li; Adriana De Siervi; Sven Bilke; Cynthia M Haggerty; Audrey Player; Yong Hong Wang; Michael J Thirman; Joseph J Kaberlein; Constantinos Petrovas; Richard A Koup; Dan Longo; Keiko Ozato; Kevin Gardner
Dynamic bookmarking of primary response genes by p300 and RNA polymerase II complexes.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(46):19286-91.
2009: Joseph P Casazza; Jason M Brenchley; Brenna J Hill; Ribka Ayana; David Ambrozak; Mario Roederer; Daniel C Douek; Michael R Betts; Richard A Koup
Autocrine production of beta-chemokines protects CMV-Specific CD4 T cells from HIV infection.
PLoS pathogens 2009;5(10):e1000646.
2009: Christof Geldmacher; Ian S Metzler; Sodsai Tovanabutra; Tedi E Asher; Emma Gostick; David R Ambrozak; Constantinos Petrovas; Alexandra Schuetz; Njabulo Ngwenyama; Gustavo Kijak; Leonard Maboko; Michael Hoelscher; Francine McCutchan; David A Price; Daniel C Douek; Richard A Koup
Minor viral and host genetic polymorphisms can dramatically impact the biologic outcome of an epitope-specific CD8 T-cell response.
Blood 2009;114(8):1553-62.
2009: Constantinos Petrovas; Benjamin Chaon; David R Ambrozak; David A Price; J Joseph Melenhorst; Brenna J Hill; Christof Geldmacher; Joseph P Casazza; Pratip K Chattopadhyay; Mario Roederer; Daniel C Douek; Yvonne M Mueller; Jeffrey M Jacobson; Viraj Kulkarni; Barbara K Felber; George Pavlakis; Peter D Katsikis; Richard A Koup
Differential association of programmed death-1 and CD57 with ex vivo survival of CD8+ T cells in HIV infection.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(2):1120-32.
2009: William C Adams; Emily Bond; Menzo J E Havenga; Lennart Holterman; Jaap Goudsmit; Gunilla B Karlsson Hedestam; Richard A Koup; Karin Loré
Adenovirus serotype 5 infects human dendritic cells via a coxsackievirus-adenovirus receptor-independent receptor pathway mediated by lactoferrin and DC-SIGN.
The Journal of general virology 2009;90(Pt 7):1600-10.
2009: Richard A Koup; Laurie Lamoreaux; David Zarkowsky; Robert T Bailer; C Richter King; Jason G D Gall; Douglas E Brough; Barney S Graham; Mario Roederer
Replication-defective adenovirus vectors with multiple deletions do not induce measurable vector-specific T cells in human trials.
Journal of virology 2009;83(12):6318-22.
2009: Yan-Ying Fan; Zi-tong Huang; Li Li; Man-Hui Wu; Tao Yu; Richard A Koup; Robert T Bailer; Chang-You Wu
Characterization of SARS-CoV-specific memory T cells from recovered individuals 4 years after infection.
Archives of virology 2009;154(7):1093-9.
2009: Daniel C Douek; Mario Roederer; Richard A Koup
Emerging concepts in the immunopathogenesis of AIDS.
Annual review of medicine 2009;60():471-84.
2008: Christof Geldmacher; Alexandra Schuetz; Njabulo Ngwenyama; Joseph P Casazza; Erica Sanga; Elmar Saathoff; Catharina Boehme; Steffen Geis; Leonard Maboko; Mahavir Singh; Fred Minja; Andreas Meyerhans; Richard A Koup; Michael Hoelscher
Early depletion of Mycobacterium tuberculosis-specific T helper 1 cell responses after HIV-1 infection.
The Journal of infectious diseases 2008;198(11):1590-8.
2008: Julie E Martin; Mark K Louder; LaSonji A Holman; Ingelise J Gordon; Mary E Enama; Brenda D Larkin; Charla A Andrews; Leatrice Vogel; Richard A Koup; Mario Roederer; Robert T Bailer; Phillip L Gomez; Martha Nason; John R Mascola; Gary Nabel; Barney S Graham
A SARS DNA vaccine induces neutralizing antibody and cellular immune responses in healthy adults in a Phase I clinical trial.
Vaccine 2008;26(50):6338-43.
2008: Melissa L Precopio; Tiffany R Butterfield; Joseph P Casazza; Susan J Little; Douglas D Richman; Richard A Koup; Mario Roederer
Optimizing peptide matrices for identifying T-cell antigens.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2008;73(11):1071-8.
2008: Rebecca L Sheets; Judith Stein; Robert T Bailer; Richard A Koup; Charla Andrews; Martha Nason; Bin He; Edward Koo; Holly Trotter; Chris Duffy; Timothy Scott Manetz; Phillip Gomez
Biodistribution and toxicological safety of adenovirus type 5 and type 35 vectored vaccines against human immunodeficiency virus-1 (HIV-1), Ebola, or Marburg are similar despite differing adenovirus serotype vector, manufacturer's construct, or gene inserts.
Journal of immunotoxicology 2008;5(3):315-35.
2008: Valentina Cecchinato; Elzbieta Tryniszewska; Zhong Min Ma; Monica Vaccari; Adriano Boasso; Wen-Po Tsai; Constantinos Petrovas; Dietmar Fuchs; Jean-Michel Heraud; David Venzon; Gene M Shearer; Richard A Koup; Israel Lowy; Christopher J Miller; Genoveffa Franchini
Immune activation driven by CTLA-4 blockade augments viral replication at mucosal sites in simian immunodeficiency virus infection.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(8):5439-47.
2008: Melody G Duvall; Melissa L Precopio; David A Ambrozak; Assan Jaye; Andrew J McMichael; Hilton C Whittle; Mario Roederer; Sarah L Rowland-Jones; Richard A Koup
Polyfunctional T cell responses are a hallmark of HIV-2 infection.
European journal of immunology 2008;38(2):350-63.
2007: Julie E Martin; Theodore C Pierson; Sarah Hubka; Steve Rucker; Ingelise J Gordon; Mary E Enama; Charla A Andrews; Qing Xu; Brent S Davis; Martha Nason; Michael Fay; Richard A Koup; Mario Roederer; Robert T Bailer; Phillip L Gomez; John R Mascola; Gwong-Jen J Chang; Gary Nabel; Barney S Graham
A West Nile virus DNA vaccine induces neutralizing antibody in healthy adults during a phase 1 clinical trial.
The Journal of infectious diseases 2007;196(12):1732-40.
2007: Melody G Duvall; Karin Loré; Hetty Blaak; David A Ambrozak; William C Adams; Kathlyn Santos; Christof Geldmacher; John R Mascola; Andrew J McMichael; Assan Jaye; Hilton C Whittle; Sarah L Rowland-Jones; Richard A Koup
Dendritic cells are less susceptible to human immunodeficiency virus type 2 (HIV-2) infection than to HIV-1 infection.
Journal of virology 2007;81(24):13486-98.
2007: Natalie E R Beveridge; David A Price; Joseph P Casazza; Ansar A Pathan; Clare R Sander; Tedi E Asher; David R Ambrozak; Melissa L Precopio; Phillip Scheinberg; Nicola C Alder; Mario Roederer; Richard A Koup; Daniel C Douek; Adrian V S Hill; Helen McShane
Immunisation with BCG and recombinant MVA85A induces long-lasting, polyfunctional Mycobacterium tuberculosis-specific CD4+ memory T lymphocyte populations.
European journal of immunology 2007;37(11):3089-100.
2007: Litao Yang; Hui Peng; Zhaoling Zhu; Gang Li; Zitong Huang; Zhixin Zhao; Richard A Koup; Robert T Bailer; Changyou Wu
Persistent memory CD4+ and CD8+ T-cell responses in recovered severe acute respiratory syndrome (SARS) patients to SARS coronavirus M antigen.
The Journal of general virology 2007;88(Pt 10):2740-8.
2007: Karin Loré; William C Adams; Menzo J E Havenga; Melissa L Precopio; Lennart Holterman; Jaap Goudsmit; Richard A Koup
Myeloid and plasmacytoid dendritic cells are susceptible to recombinant adenovirus vectors and stimulate polyfunctional memory T cell responses.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(3):1721-9.
2007: Constantinos Petrovas; David A Price; Joseph J Mattapallil; David R Ambrozak; Christof Geldmacher; Valentina Cecchinato; Monica Vaccari; Elzbieta Tryniszewska; Emma Gostick; Mario Roederer; Daniel C Douek; Sara H Morgan; Simon J Davis; Genoveffa Franchini; Richard A Koup
SIV-specific CD8+ T cells express high levels of PD1 and cytokines but have impaired proliferative capacity in acute and chronic SIVmac251 infection.
Blood 2007;110(3):928-36.
2007: Ruth Seggewiss; Karin Loré; F Javier Guenaga; Stefania Pittaluga; Joseph J Mattapallil; Catherine K Chow; Richard A Koup; Kevin A Camphausen; Martha C Nason; Martin Meier-Schellersheim; Robert E Donahue; Bruce R Blazar; Cynthia E Dunbar; Daniel C Douek
Keratinocyte growth factor augments immune reconstitution after autologous hematopoietic progenitor cell transplantation in rhesus macaques.
Blood 2007;110(1):441-9.
2007: Melissa L Precopio; Michael R Betts; Janie Parrino; David A Price; Emma Gostick; David R Ambrozak; Tedi E Asher; Daniel C Douek; Alexandre Harari; Giuseppe Pantaleo; Robert T Bailer; Barney S Graham; Mario Roederer; Richard A Koup
Immunization with vaccinia virus induces polyfunctional and phenotypically distinctive CD8(+) T cell responses.
The Journal of experimental medicine 2007;204(6):1405-16.
2007: Andrew T Catanzaro; Mario Roederer; Richard A Koup; Robert T Bailer; Mary E Enama; Martha C Nason; Julie E Martin; Steve Rucker; Charla A Andrews; Phillip L Gomez; John R Mascola; Gary Nabel; Barney S Graham
Phase I clinical evaluation of a six-plasmid multiclade HIV-1 DNA candidate vaccine.
Vaccine 2007;25(20):4085-92.
2007: Jorge A Tavel; Julie E Martin; Grace G Kelly; Mary E Enama; Jean M Shen; Phillip L Gomez; Charla A Andrews; Richard A Koup; Robert T Bailer; Judy A Stein; Mario Roederer; Gary Nabel; Barney S Graham
Safety and immunogenicity of a Gag-Pol candidate HIV-1 DNA vaccine administered by a needle-free device in HIV-1-seronegative subjects.
Journal of acquired immune deficiency syndromes (1999) 2007;44(5):601-5.
2007: Anna Hryniewicz; David A Price; Marcin Moniuszko; Adriano Boasso; Yvette Edghill-Spano; Sadie M West; David Venzon; Monica Vaccari; Wen-Po Tsai; Elzbieta Tryniszewska; Janos Nacsa; Francios VILLINGER; Aftab A Ansari; Christopher J Trindade; Michel MORRE; David Brooks; Philip M Arlen; Helen J Brown; Christina Kitchen; Jerome A Zack; Daniel C Douek; Gene M Shearer; Mark G Lewis; Richard A Koup; Genoveffa Franchini
Interleukin-15 but not interleukin-7 abrogates vaccine-induced decrease in virus level in simian immunodeficiency virus mac251-infected macaques.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(6):3492-504.
2007: Janie Parrino; Lewis H McCurdy; Brenda D Larkin; Ingelise J Gordon; Steven E Rucker; Mary E Enama; Richard A Koup; Mario Roederer; Robert T Bailer; Zoe Moodie; Lin Gu; Lihan Yan; Barney S Graham
Safety, immunogenicity and efficacy of modified vaccinia Ankara (MVA) against Dryvax challenge in vaccinia-naïve and vaccinia-immune individuals.
Vaccine 2007;25(8):1513-25.
2006: Joseph P Casazza; Michael R Betts; David A Price; Melissa L Precopio; Laura E Ruff; Jason M Brenchley; Brenna J Hill; Mario Roederer; Daniel C Douek; Richard A Koup
Acquisition of direct antiviral effector functions by CMV-specific CD4+ T lymphocytes with cellular maturation.
The Journal of experimental medicine 2006;203(13):2865-77.
2006: Barney S Graham; Richard A Koup; Mario Roederer; Robert T Bailer; Mary E Enama; Zoe Moodie; Julie E Martin; Margaret M McCluskey; Bimal K Chakrabarti; Laurie Lamoreaux; Charla A Andrews; Phillip L Gomez; John R Mascola; Gary Nabel
Phase 1 safety and immunogenicity evaluation of a multiclade HIV-1 DNA candidate vaccine.
The Journal of infectious diseases 2006;194(12):1650-60.
2006: Andrew T Catanzaro; Richard A Koup; Mario Roederer; Robert T Bailer; Mary E Enama; Zoe Moodie; Lin Gu; Julie E Martin; Laura Novik; Bimal K Chakrabarti; Bryan Butman; Jason G D Gall; C Richter King; Charla A Andrews; Rebecca L Sheets; Phillip L Gomez; John R Mascola; Gary Nabel; Barney S Graham
Phase 1 safety and immunogenicity evaluation of a multiclade HIV-1 candidate vaccine delivered by a replication-defective recombinant adenovirus vector.
The Journal of infectious diseases 2006;194(12):1638-49.
2006: Julie E Martin; Nancy J Sullivan; Mary E Enama; Ingelise J Gordon; Mario Roederer; Richard A Koup; Robert T Bailer; Bimal K Chakrabarti; Michael A Bailey; Phillip L Gomez; Charla A Andrews; Zoe Moodie; Lin Gu; Judith A Stein; Gary Nabel; Barney S Graham
A DNA vaccine for Ebola virus is safe and immunogenic in a phase I clinical trial.
Clinical and vaccine immunology : CVI 2006;13(11):1267-77.
2006: Constantinos Petrovas; Joseph P Casazza; Jason M Brenchley; David A Price; Emma Gostick; William C Adams; Melissa L Precopio; Timothy W Schacker; Mario Roederer; Daniel C Douek; Richard A Koup
PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection.
The Journal of experimental medicine 2006;203(10):2281-92.
2006: Pratip K Chattopadhyay; David A Price; Theresa F Harper; Michael R Betts; Joanne Yu; Emma Gostick; Stephen P Perfetto; Paul A Goepfert; Richard A Koup; Stephen C De Rosa; Marcel P Bruchez; Mario Roederer
Quantum dot semiconductor nanocrystals for immunophenotyping by polychromatic flow cytometry.
Nature medicine 2006;12(8):972-7.
2006: Hui Peng; Li-tao Yang; Jian Li; Zhi-qiang Lu; Ling-yun Wang; Richard A Koup; Robert T Bailer; Chang-you Wu
Human memory T cell responses to SARS-CoV E protein.
Microbes and infection / Institut Pasteur 2006;8(9-10):2424-31.
2006: Li-tao Yang; Hui Peng; Zhao-Ling Zhu; Gang Li; Zi-tong Huang; Zhi-Xin Zhao; Richard A Koup; Robert T Bailer; Chang-You Wu
Long-lived effector/central memory T-cell responses to severe acute respiratory syndrome coronavirus (SARS-CoV) S antigen in recovered SARS patients.
Clinical immunology (Orlando, Fla.) 2006;120(2):171-8.
2006: Hui Peng; Li-tao Yang; Ling-yun Wang; Jian Li; Jun Huang; Zhi-qiang Lu; Richard A Koup; Robert T Bailer; Chang-you Wu
Long-lived memory T lymphocyte responses against SARS coronavirus nucleocapsid protein in SARS-recovered patients.
Virology 2006;351(2):466-75.
2006: Jason M Brenchley; Laura E Ruff; Joseph P Casazza; Richard A Koup; David A Price; Daniel C Douek
Preferential infection shortens the life span of human immunodeficiency virus-specific CD4+ T cells in vivo.
Journal of virology 2006;80(14):6801-9.
2006: Stephen P Perfetto; Pratip K Chattopadhyay; Laurie Lamoreaux; Richard Nguyen; David R Ambrozak; Richard A Koup; Mario Roederer
Amine reactive dyes: an effective tool to discriminate live and dead cells in polychromatic flow cytometry.
Journal of immunological methods 2006;313(1-2):199-208.
2006: Michael R Betts; Martha C Nason; Sadie M West; Stephen C De Rosa; Stephen A Migueles; Jonathan Abraham; Michael M Lederman; Jose M Benito; Paul A Goepfert; Mark Connors; Mario Roederer; Richard A Koup
HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells.
Blood 2006;107(12):4781-9.
2006: Melody G Duvall; Assan Jaye; Tao Dong; Jason M Brenchley; Abraham Alabi; David J Jeffries; Marianne A B van der Sande; Toyin O Togun; Samuel J McConkey; Daniel C Douek; Andrew J McMichael; Hilton C Whittle; Richard A Koup; Sarah L Rowland-Jones
Maintenance of HIV-specific CD4+ T cell help distinguishes HIV-2 from HIV-1 infection.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(11):6973-81.
2006: Nancy J Sullivan; Thomas W Geisbert; Joan B Geisbert; Devon Shedlock; Ling Xu; Laurie Lamoreaux; Jerome H H V Custers; Paul M Popernack; Zhi-Yong Yang; Maria G Pau; Mario Roederer; Richard A Koup; Jaap Goudsmit; Peter B Jahrling; Gary Nabel
Immune protection of nonhuman primates against Ebola virus with single low-dose adenovirus vectors encoding modified GPs.
PLoS medicine 2006;3(6):e177.
2006: Karin Loré; Ruth Seggewiss; F Javier Guenaga; Stefania Pittaluga; Robert E Donahue; Allen Krouse; Mark E Metzger; Richard A Koup; Cavan Reilly; Daniel C Douek; Cynthia E Dunbar
In vitro culture during retroviral transduction improves thymic repopulation and output after total body irradiation and autologous peripheral blood progenitor cell transplantation in rhesus macaques.
Stem cells (Dayton, Ohio) 2006;24(6):1539-48.
2006: Ulrike Wille-Reece; Barbara J Flynn; Karin Loré; Richard A Koup; Aaron P Miles; Allan Saul; Ross M Kedl; Joseph J Mattapallil; Walter R Weiss; Mario Roederer; Robert A Seder
Toll-like receptor agonists influence the magnitude and quality of memory T cell responses after prime-boost immunization in nonhuman primates.
The Journal of experimental medicine 2006;203(5):1249-58.
2006: Laurie Lamoreaux; Mario Roederer; Richard A Koup
Intracellular cytokine optimization and standard operating procedure.
Nature protocols 2006;1(3):1507-16.
2005: David A Price; Jason M Brenchley; Laura E Ruff; Michael R Betts; Brenna J Hill; Mario Roederer; Richard A Koup; Stephen A Migueles; Emma Gostick; Linda Wooldridge; Andrew K Sewell; Mark Connors; Daniel C Douek
Avidity for antigen shapes clonal dominance in CD8+ T cell populations specific for persistent DNA viruses.
The Journal of experimental medicine 2005;202(10):1349-61.
2005: Ulrike Wille-Reece; Barbara J Flynn; Karin Loré; Richard A Koup; Ross M Kedl; Joseph J Mattapallil; Walter R Weiss; Mario Roederer; Robert A Seder
HIV Gag protein conjugated to a Toll-like receptor 7/8 agonist improves the magnitude and quality of Th1 and CD8+ T cell responses in nonhuman primates.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(42):15190-4.
2005: Anna Smed-Sörensen; Karin Loré; Jayanand Vasudevan; Mark K Louder; Jan Andersson; John R Mascola; Anna-Lena Spetz; Richard A Koup
Differential susceptibility to human immunodeficiency virus type 1 infection of myeloid and plasmacytoid dendritic cells.
Journal of virology 2005;79(14):8861-9.
2005: Greg M Podsakoff; Barbara C Engel; Denise A Carbonaro; Chris Choi; Elzbieta Monika Smogorzewska; Gerhard Bauer; David Selander; Susan Csik; Kathy Wilson; Michael R Betts; Richard A Koup; Gary Nabel; D Keith Bishop; Steven R King; Manfred Schmidt; Christof von Kalle; Joseph A Church; Donald B Kohn
Selective survival of peripheral blood lymphocytes in children with HIV-1 following delivery of an anti-HIV gene to bone marrow CD34(+) cells.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;12(1):77-86.
2005: Karin Loré; Anna Smed-Sörensen; Jayanand Vasudevan; John R Mascola; Richard A Koup
Myeloid and plasmacytoid dendritic cells transfer HIV-1 preferentially to antigen-specific CD4+ T cells.
The Journal of experimental medicine 2005;201(12):2023-33.
2005: Michael R Betts; Barbara Exley; David A Price; Anju Bansal; Zenaido Tres Camacho; Vanessa Teaberry; Sadie M West; David R Ambrozak; Georgia D Tomaras; Mario Roederer; J. Michael Kilby; Jim Tartaglia; Robert B Belshe; Feng Gao; Daniel C Douek; Kent J Weinhold; Richard A Koup; Paul A Goepfert; Guido Ferrari
Characterization of functional and phenotypic changes in anti-Gag vaccine-induced T cell responses and their role in protection after HIV-1 infection.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(12):4512-7.
2005: Joseph P Casazza; Michael R Betts; Brenna J Hill; Jason M Brenchley; David A Price; Daniel C Douek; Richard A Koup
Immunologic pressure within class I-restricted cognate human immunodeficiency virus epitopes during highly active antiretroviral therapy.
Journal of virology 2005;79(6):3653-63.
2005: Michael S Seaman; Ling Xu; Kristin Beaudry; Kristi L Martin; Margaret H Beddall; Ayako Miura; Anna Sambor; Bimal K Chakrabarti; Yue Huang; Robert T Bailer; Richard A Koup; John R Mascola; Gary Nabel; Norman L Letvin
Multiclade human immunodeficiency virus type 1 envelope immunogens elicit broad cellular and humoral immunity in rhesus monkeys.
Journal of virology 2005;79(5):2956-63.
2004: David A Price; Sadie M West; Michael R Betts; Laura E Ruff; Jason M Brenchley; David R Ambrozak; Yvette Edghill Spano; Marcelo J Kuroda; Derek Bogdan; Kevin Kunstman; Norman L Letvin; Genoveffa Franchini; Steven Wolinsky; Richard A Koup; Daniel C Douek
T cell receptor recognition motifs govern immune escape patterns in acute SIV infection.
Immunity 2004;21(6):793-803.
2004: Richard A Koup
Reconsidering early HIV treatment and supervised treatment interruptions.
PLoS medicine 2004;1(2):e41.
2004: Stephen C De Rosa; Fabien X Lu; Joanne Yu; Stephen P Perfetto; Judith Falloon; Susan Moser; Thomas G Evans; Richard A Koup; Christopher J Miller; Mario Roederer
Vaccination in humans generates broad T cell cytokine responses.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(9):5372-80.
2004: Lakshmanan Ganesh; Kwanyee Leung; Karin Loré; Reuven Levin; Amos Panet; Owen Schwartz; Richard A Koup; Gary Nabel
Infection of specific dendritic cells by CCR5-tropic human immunodeficiency virus type 1 promotes cell-mediated transmission of virus resistant to broadly neutralizing antibodies.
Journal of virology 2004;78(21):11980-7.
2004: Giuseppe Pantaleo; Richard A Koup
Correlates of immune protection in HIV-1 infection: what we know, what we don't know, what we should know.
Nature medicine 2004;10(8):806-10.
2004: Guido Ferrari; Wesley Neal; Janet Ottinger; Anizsa M Jones; Bradley H Edwards; Paul A Goepfert; Michael R Betts; Richard A Koup; Susan Buchbinder; M Juliana McElrath; Jim Tartaglia; Kent J Weinhold
Absence of immunodominant anti-Gag p17 (SL9) responses among Gag CTL-positive, HIV-uninfected vaccine recipients expressing the HLA-A*0201 allele.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(3):2126-33.
2004: Michael P Crawford; Shirley X Yan; Sterling B Ortega; Riyaz S Mehta; Rachel E Hewitt; David A Price; Peter Stastny; Daniel C Douek; Richard A Koup; Michael K Racke; Nitin J Karandikar
High prevalence of autoreactive, neuroantigen-specific CD8+ T cells in multiple sclerosis revealed by novel flow cytometric assay.
Blood 2004;103(11):4222-31.
2004: Michael R Betts; David A Price; Jason M Brenchley; Karin Loré; F Javier Guenaga; Anna Smed-Sorensen; David R Ambrozak; Stephen A Migueles; Mark Connors; Mario Roederer; Daniel C Douek; Richard A Koup
The functional profile of primary human antiviral CD8+ T cell effector activity is dictated by cognate peptide concentration.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(10):6407-17.
2004: Lucy Golden-Mason; Daniel C Douek; Richard A Koup; Jacinta Kelly; John E Hegarty; Cliona O'Farrelly
Adult human liver contains CD8pos T cells with naive phenotype, but is not a site for conventional alpha beta T cell development.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(10):5980-5.
2004: Petra Wolint; Michael R Betts; Richard A Koup; Annette Oxenius
Immediate cytotoxicity but not degranulation distinguishes effector and memory subsets of CD8+ T cells.
The Journal of experimental medicine 2004;199(7):925-36.
2004: Makoto Sugaya; Karin Loré; Richard A Koup; Daniel C Douek; Andrew Blauvelt
HIV-infected Langerhans cells preferentially transmit virus to proliferating autologous CD4+ memory T cells located within Langerhans cell-T cell clusters.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(4):2219-24.
2004: Jason M Brenchley; Brenna J Hill; David R Ambrozak; David A Price; F Javier Guenaga; Joseph P Casazza; Janaki C Kuruppu; Javaidia Yazdani; Stephen A Migueles; Mark Connors; Mario Roederer; Daniel C Douek; Richard A Koup
T-cell subsets that harbor human immunodeficiency virus (HIV) in vivo: implications for HIV pathogenesis.
Journal of virology 2004;78(3):1160-8.
2004: Michael R Betts; Richard A Koup
Detection of T-cell degranulation: CD107a and b.
Methods in cell biology 2004;75():497-512.
2004: Ingrid Schmid; Mario Roederer; Richard A Koup; David R Ambrozak; Stephen P Perfetto
Biohazard sorting.
Methods in cell biology 2004;75():221-40.
2004: Stephen P Perfetto; David R Ambrozak; Mario Roederer; Richard A Koup
Viable infectious cell sorting in a BSL-3 facility.
Methods in molecular biology (Clifton, N.J.) 2004;263():419-24.
2003: Karin Loré; Michael R Betts; Jason M Brenchley; Janaki C Kuruppu; Soorena Khojasteh; Stephen P Perfetto; Mario Roederer; Robert A Seder; Richard A Koup
Toll-like receptor ligands modulate dendritic cells to augment cytomegalovirus- and HIV-1-specific T cell responses.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(8):4320-8.
2003: Michael R Betts; Jason M Brenchley; David A Price; Stephen C De Rosa; Daniel C Douek; Mario Roederer; Richard A Koup
Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation.
Journal of immunological methods 2003;281(1-2):65-78.
2003: Nancy J Sullivan; Thomas W Geisbert; Joan B Geisbert; Ling Xu; Zhi-Yong Yang; Mario Roederer; Richard A Koup; Peter B Jahrling; Gary Nabel
Accelerated vaccination for Ebola virus haemorrhagic fever in non-human primates.
Nature 2003;424(6949):681-4.
2003: Mireya Diaz; Daniel C Douek; Hernan Valdez; Brenna J Hill; Dolores Peterson; Ian Sanne; Peter J Piliero; Richard A Koup; Sylvan B Green; Steven Schnittman; Michael M Lederman
T cells containing T cell receptor excision circles are inversely related to HIV replication and are selectively and rapidly released into circulation with antiretroviral treatment.
AIDS (London, England) 2003;17(8):1145-9.
2003: Stephen P Perfetto; David R Ambrozak; Richard A Koup; Mario Roederer
Measuring containment of viable infectious cell sorting in high-velocity cell sorters.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2003;52(2):122-30.
2003: Jason M Brenchley; Nitin J Karandikar; Michael R Betts; David R Ambrozak; Brenna J Hill; Laura E Crotty; Joseph P Casazza; Janaki C Kuruppu; Stephen A Migueles; Mark Connors; Mario Roederer; Daniel C Douek; Richard A Koup
Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells.
Blood 2003;101(7):2711-20.
2003: Guido Silvestri; Donald L Sodora; Richard A Koup; Mirko Paiardini; Shawn P O'Neil; Harold M McClure; Silvija I Staprans; Mark B Feinberg
Nonpathogenic SIV infection of sooty mangabeys is characterized by limited bystander immunopathology despite chronic high-level viremia.
Immunity 2003;18(3):441-52.
2003: Mario Roederer; Richard A Koup
Optimized determination of T cell epitope responses.
Journal of immunological methods 2003;274(1-2):221-8.
2003: Joseph A Leonetti; Richard A Koup
Localized maxillary ridge augmentation with a block allograft for dental implant placement: case reports.
Implant dentistry 2003;12(3):217-26.
2003: Daniel C Douek; Louis J Picker; Richard A Koup
T cell dynamics in HIV-1 infection.
Annual review of immunology 2003;21():265-304.
2002: J M Brenchley; Daniel C Douek; David R Ambrozak; M Chatterji; Michael R Betts; L S Davis; Richard A Koup
Expansion of activated human naïve T-cells precedes effector function.
Clinical and experimental immunology 2002;130(3):432-40.
2002: Donald L Sodora; Jeffrey M Milush; Felecia Ware; Aneta Wozniakowski; Lisa Montgomery; Harold M McClure; Andrew Lackner; Marta L Marthas; Vanessa Hirsch; R Paul Johnson; Daniel C Douek; Richard A Koup
Decreased levels of recent thymic emigrants in peripheral blood of simian immunodeficiency virus-infected macaques correlate with alterations within the thymus.
Journal of virology 2002;76(19):9981-90.
2002: Michael R Betts; Karina Yusim; Richard A Koup
Optimal antigens for HIV vaccines based on CD8+ T response, protein length, and sequence variability.
DNA and cell biology 2002;21(9):665-70.
2002: Susan J Little; Sarah Holte; Jean-Pierre Routy; Eric S Daar; Marty Markowitz; Ann C Collier; Richard A Koup; John W Mellors; Elizabeth Connick; Brian Conway; Michael Kilby; Lei Wang; Jeannette M Whitcomb; Nicholas S Hellmann; Douglas D Richman
Antiretroviral-drug resistance among patients recently infected with HIV.
The New England journal of medicine 2002;347(6):385-94.
2002: Daniel C Douek; Jason M Brenchley; Michael R Betts; David R Ambrozak; Brenna J Hill; Yukari Okamoto; Joseph P Casazza; Janaki C Kuruppu; Kevin Kunstman; Steven Wolinsky; Zvi Grossman; Mark Dybul; Annette Oxenius; David A Price; Mark Connors; Richard A Koup
HIV preferentially infects HIV-specific CD4+ T cells.
Nature 2002;417(6884):95-8.
2002: Yukari Okamoto; Daniel C Douek; Richard D McFarland; Richard A Koup
Effects of exogenous interleukin-7 on human thymus function.
Blood 2002;99(8):2851-8.
2002: Lucia Ometto; Davide De Forni; Fiorulla Patiri; Virginie Trouplin; Fabrizio Mammano; Vania Giacomet; Carlo Giaquinto; Daniel Douek; Richard A Koup; Anita De Rossi
Immune reconstitution in HIV-1-infected children on antiretroviral therapy: role of thymic output and viral fitness.
AIDS (London, England) 2002;16(6):839-49.
2002: Daniel C Douek; Michael R Betts; Jason M Brenchley; Brenna J Hill; David R Ambrozak; Ka-Leung Ngai; Nitin J Karandikar; Joseph P Casazza; Richard A Koup
A novel approach to the analysis of specificity, clonality, and frequency of HIV-specific T cell responses reveals a potential mechanism for control of viral escape.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(6):3099-104.
2002: Nitin J Karandikar; Michael P Crawford; Xiao Yan; Robert B Ratts; Jason M Brenchley; David R Ambrozak; Amy E Lovett-Racke; Elliot M Frohman; Peter Stastny; Daniel C Douek; Richard A Koup; Michael K Racke
Glatiramer acetate (Copaxone) therapy induces CD8(+) T cell responses in patients with multiple sclerosis.
The Journal of clinical investigation 2002;109(5):641-9.
2002: Yukari Okamoto; Daniel C Douek; Richard D McFarland; Richard A Koup
IL-7, the thymus, and naïve T cells.
Advances in experimental medicine and biology 2002;512():81-90.
2001: Daniel C Douek; Michael R Betts; Brenna J Hill; S J Little; Richard A Lempicki; Julia A Metcalf; Joseph P Casazza; Christian Yoder; Joseph W Adelsberger; Randy A Stevens; Michael Baseler; Philip H Keiser; Douglas D Richman; Richard Davey; Richard A Koup
Evidence for increased T cell turnover and decreased thymic output in HIV infection.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(11):6663-8.
2001: Michael R Betts; David R Ambrozak; Daniel C Douek; Sebastian Bonhoeffer; Jason M Brenchley; Joseph P Casazza; Richard A Koup; Louis J Picker
Analysis of total human immunodeficiency virus (HIV)-specific CD4(+) and CD8(+) T-cell responses: relationship to viral load in untreated HIV infection.
Journal of virology 2001;75(24):11983-91.
2001: Michael R Betts; Joseph P Casazza; Richard A Koup
Monitoring HIV-specific CD8+ T cell responses by intracellular cytokine production.
Immunology letters 2001;79(1-2):117-25.
2001: L Teixeira; Hernan Valdez; Joseph M McCune; Richard A Koup; andrew badley; Marc K Hellerstein; Laura A Napolitano; Daniel C Douek; Georgina Mbisa; Steven Deeks; J M Harris; Jason D Barbour; Barry H Gross; Isaac R Francis; Robert A Halvorsen; Robert Asaad; Michael M Lederman
Poor CD4 T cell restoration after suppression of HIV-1 replication may reflect lower thymic function.
AIDS (London, England) 2001;15(14):1749-56.
2001: E J Aarons; S Beddows; T Willingham; L Wu; Richard A Koup
Adaptation to blockade of human immunodeficiency virus type 1 entry imposed by the anti-CCR5 monoclonal antibody 2D7.
Virology 2001;287(2):382-90.
2001: Joseph P Casazza; Michael R Betts; Louis J Picker; Richard A Koup
Decay kinetics of human immunodeficiency virus-specific CD8+ T cells in peripheral blood after initiation of highly active antiretroviral therapy.
Journal of virology 2001;75(14):6508-16.
2001: Kenneth I Weinberg; B R Blazar; J E Wagner; Edward D Agura; Brenna J Hill; M Smogorzewska; Richard A Koup; Michael R Betts; Robert H Collins; Daniel C Douek
Factors affecting thymic function after allogeneic hematopoietic stem cell transplantation.
Blood 2001;97(5):1458-66.
2001: Gregory D Sempowski; James R Thomasch; Maria E Gooding; L Hale; L Edwards; Emma Ciafaloni; D Sanders; Janice M Massey; D Douek; Richard A Koup; B Haynes
Effect of thymectomy on human peripheral blood T cell pools in myasthenia gravis.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(4):2808-17.
2000: JT Evans; Yukari Okamoto; Daniel C Douek; RD McFarland; Joel Gatlin; Richard A Koup; Jose Garcia-Martinez
Thymocyte differentiation from lentivirus-marked CD34(+) cells in infant and adult human thymus.
Journal of immunological methods 2000;245(1-2):31-43.
2000: Michael R Betts; Joseph P Casazza; B A Patterson; Sharon Waldrop; Wendy Trigona; Tong-Ming Fu; Florian Kern; Louis J Picker; Richard A Koup
Putative immunodominant human immunodeficiency virus-specific CD8(+) T-cell responses cannot be predicted by major histocompatibility complex class I haplotype.
Journal of virology 2000;74(19):9144-51.
2000: Daniel C Douek; Robert A Vescio; Michael R Betts; Jason M Brenchley; Brenna J Hill; L Zhang; J R Berenson; Robert H Collins; Richard A Koup
Assessment of thymic output in adults after haematopoietic stem-cell transplantation and prediction of T-cell reconstitution.
Lancet 2000;355(9218):1875-81.
2000: RD McFarland; Daniel C Douek; Richard A Koup; Louis J Picker
Identification of a human recent thymic emigrant phenotype.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(8):4215-20.
2000: Daniel C Douek; Richard A Koup; RD McFarland; John L Sullivan; K Luzuriaga
Effect of HIV on thymic function before and after antiretroviral therapy in children.
The Journal of infectious diseases 2000;181(4):1479-82.
2000: Donald L Sodora; Daniel C Douek; Guido Silvestri; Lisa Montgomery; M Rosenzweig; T Igarashi; B Bernacky; R Paul Johnson; Mark B Feinberg; Malcolm Martin; Richard A Koup
Quantification of thymic function by measuring T cell receptor excision circles within peripheral blood and lymphoid tissues in monkeys.
European journal of immunology 2000;30(4):1145-53.
2000: M Louise Markert; Charles B Hicks; John A Bartlett; J L Harmon; Laura P Hale; ML Greenberg; Guido Ferrari; Janet Ottinger; A Boeck; A L Kloster; TM McLaughlin; KAREN BLEICH; R M Ungerleider; H Kim Lyerly; William E Wilkinson; Franck Rousseau; ME Heath-Chiozzi; JM Leonard; Ashley T Haase; George M Shaw; R Pat Bucy; D C Douek; Richard A Koup; Barton F Haynes; Dani P Bolognesi; Kent J Weinhold
Effect of highly active antiretroviral therapy and thymic transplantation on immunoreconstitution in HIV infection.
AIDS research and human retroviruses 2000;16(5):403-13.
2000: Daniel C Douek; Richard A Koup
Evidence for thymic function in the elderly.
Vaccine 2000;18(16):1638-41.
2000: Gregory D Sempowski; Laura P Hale; John S Sundy; Janice M Massey; Richard A Koup; D C Douek; Dhavalkumar D Patel; Barton F Haynes
Leukemia inhibitory factor, oncostatin M, IL-6, and stem cell factor mRNA expression in human thymus increases with age and is associated with thymic atrophy.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(4):2180-7.
2000: Timothy J Sellati; D A Wilkinson; Jeanne S Sheffield; Richard A Koup; Justin D Radolf; Michael V Norgard
Virulent Treponema pallidum, lipoprotein, and synthetic lipopeptides induce CCR5 on human monocytes and enhance their susceptibility to infection by human immunodeficiency virus type 1.
The Journal of infectious diseases 2000;181(1):283-93.
1999: M Louise Markert; A Boeck; Laura P Hale; A L Kloster; TM McLaughlin; Milena Batchvarova; D C Douek; Richard A Koup; DD Kostyu; FE Ward; Henry E Rice; Samuel M Mahaffey; SE Schiff; Rebecca H Buckley; Barton F Haynes
Transplantation of thymus tissue in complete DiGeorge syndrome.
The New England journal of medicine 1999;341(16):1180-9.
1999: Christine J Pitcher; C Quittner; Dolores M Peterson; M Connors; Richard A Koup; Vernon C Maino; Louis J Picker
HIV-1-specific CD4+ T cells are detectable in most individuals with active HIV-1 infection, but decline with prolonged viral suppression.
Nature medicine 1999;5(5):518-25.
1998: Daniel C Douek; RD McFarland; Philip Keiser; E A Gage; J M Massey; B F Haynes; Michael A Polis; Ashley T Haase; Mark B Feinberg; John L Sullivan; B D Jamieson; Jerome A Zack; Louis J Picker; Richard A Koup
Changes in thymic function with age and during the treatment of HIV infection.
Nature 1998;396(6712):690-5.
1998: D A Wilkinson; Eva A Operskalski; Michael P Busch; James W Mosley; Richard A Koup
A 32-bp deletion within the CCR5 locus protects against transmission of parenterally acquired human immunodeficiency virus but does not affect progression to AIDS-defining illness.
The Journal of infectious diseases 1998;178(4):1163-6.