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Stephen Baldwin

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Hamidreza Vaziri; James D Young; David G Adams; Jocelyn M Baldwin; Stephen A Baldwin; Vincent Postis
Use of molecular modelling to probe the mechanism of the nucleoside transporter NupG.
Carine De Marcos Lousa; Daniela Dietrich; Ian D Kerr; Vincent Postis; Alison Baker; Stephen A Baldwin; Carlo W T van Roermund; Ronald J A Wanders; Frederica L Theodoulou
Intrinsic acyl-CoA thioesterase activity of a peroxisomal ATP binding cassette transporter is required for transport and metabolism of fatty acids.
Lin-Hua Jiang; Sebastien Roger; Jocelyn M Baldwin; Stephen A Baldwin
Insights into the Molecular Mechanisms Underlying Mammalian P2X7 Receptor Functions and Contributions in Diseases, Revealed by Structural Modeling and Single Nucleotide Polymorphisms.

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All Publications

2013: Hamidreza Vaziri; James D Young; David G Adams; Jocelyn M Baldwin; Stephen A Baldwin; Vincent Postis
Use of molecular modelling to probe the mechanism of the nucleoside transporter NupG.
Molecular membrane biology 2013;30(2):114-28.
2013: Carine De Marcos Lousa; Daniela Dietrich; Ian D Kerr; Vincent Postis; Alison Baker; Stephen A Baldwin; Carlo W T van Roermund; Ronald J A Wanders; Frederica L Theodoulou
Intrinsic acyl-CoA thioesterase activity of a peroxisomal ATP binding cassette transporter is required for transport and metabolism of fatty acids.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(4):1279-84.
2013: Lin-Hua Jiang; Sebastien Roger; Jocelyn M Baldwin; Stephen A Baldwin
Insights into the Molecular Mechanisms Underlying Mammalian P2X7 Receptor Functions and Contributions in Diseases, Revealed by Structural Modeling and Single Nucleotide Polymorphisms.
Frontiers in pharmacology 2013;4():55.
2013: Vincent G L Postis; Andrea E Rawlings; Amelia Lesiuk; Stephen A Baldwin
Use of Escherichia coli for the production and purification of membrane proteins.
Methods in molecular biology (Clifton, N.J.) 2013;998():33-54.
2012: Yvonne Nyathi; Frederica L Theodoulou; Xuebin Zhang; Jocelyn M Baldwin; Stephen A Baldwin; Kristin Bernhardt; Barbara Johnson; Alison Baker
Pseudo half-molecules of the ABC transporter, COMATOSE, bind Pex19 and target to peroxisomes independently but are both required for activity.
FEBS letters 2012;586(16):2280-6.
2012: Gerard H M Huysmans; Michael J McPherson; Vincent Postis; Svetomir B Tzokov; Sylvia Y M Yao; James D Young; Jocelyn M Baldwin; Per A Bullough; Nathan Chan; Sarah E Deacon; Stephen A Baldwin
A urea channel from Bacillus cereus reveals a novel hexameric structure.
The Biochemical journal 2012;445(2):157-66.
2012: Gerard H M Huysmans; Sheena E Radford; Stephen A Baldwin; David J Brockwell
Malleability of the folding mechanism of the outer membrane protein PagP: parallel pathways and the effect of membrane elasticity.
Journal of molecular biology 2012;416(3):453-64.
2011: Xuebin Zhang; Carine De Marcos Lousa; Nellie Schutte-Lensink; Rob Ofman; Ronald J Wanders; Stephen A Baldwin; Alison Baker; Stephan Kemp; Frederica L Theodoulou
Conservation of targeting but divergence in function and quality control of peroxisomal ABC transporters: an analysis using cross-kingdom expression.
The Biochemical journal 2011;436(3):547-57.
2011: Helen J Bradley; Jocelyn M Baldwin; G Ranjan Goli; Brian Johnson; Jie Zou; Asipu Sivaprasadarao; Stephen A Baldwin; Lin-Hua Jiang
Residues 155 and 348 contribute to the determination of P2X7 receptor function via distinct mechanisms revealed by single-nucleotide polymorphisms.
The Journal of biological chemistry 2011;286(10):8176-87.
2011: Fiona E Parkinson; Vijaya L Damaraju; Kathryn Graham; Sylvia Y M Yao; Stephen A Baldwin; Carol E Cass; James D Young
Molecular biology of nucleoside transporters and their distributions and functions in the brain.
Current topics in medicinal chemistry 2011;11(8):948-72.
2010: Yvonne Nyathi; Carine De Marcos Lousa; Carlo W van Roermund; Ronald J A Wanders; Barbara Johnson; Stephen A Baldwin; Frederica L Theodoulou; Alison Baker
The Arabidopsis peroxisomal ABC transporter, comatose, complements the Saccharomyces cerevisiae pxa1 pxa2Delta mutant for metabolism of long-chain fatty acids and exhibits fatty acyl-CoA-stimulated ATPase activity.
The Journal of biological chemistry 2010;285(39):29892-902.
2010: Gerard H M Huysmans; Stephen A Baldwin; David J Brockwell; Sheena E Radford
The transition state for folding of an outer membrane protein.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(9):4099-104.
2010: Lynsey N Jones; Stephen A Baldwin; Peter J F Henderson; Alison E Ashcroft
Defining topological features of membrane proteins by nanoelectrospray ionisation mass spectrometry.
Rapid communications in mass spectrometry : RCM 2010;24(3):276-84.
2009: Melissa D Slugoski; Kyla M Smith; Amy M L Ng; Sylvia Y M Yao; Edward Karpinski; Carol E Cass; Stephen A Baldwin; James D Young
Conserved glutamate residues Glu-343 and Glu-519 provide mechanistic insights into cation/nucleoside cotransport by human concentrative nucleoside transporter hCNT3.
The Journal of biological chemistry 2009;284(25):17266-80.
2009: Melissa D Slugoski; Amy M L Ng; Sylvia Y M Yao; Colin C Lin; Ras Mulinta; Carol E Cass; Stephen A Baldwin; James D Young
Substituted cysteine accessibility method analysis of human concentrative nucleoside transporter hCNT3 reveals a novel discontinuous region of functional importance within the CNT family motif (G/A)XKX3NEFVA(Y/M/F).
The Journal of biological chemistry 2009;284(25):17281-92.
2009: Adam N Elwi; Vijaya L Damaraju; Michelle L Kuzma; Delores A Mowles; Stephen A Baldwin; James D Young; Michael B Sawyer; Carol E Cass
Transepithelial fluxes of adenosine and 2'-deoxyadenosine across human renal proximal tubule cells: roles of nucleoside transporters hENT1, hENT2, and hCNT3.
American journal of physiology. Renal physiology 2009;296(6):F1439-51.
2009: Carine De Marcos Lousa; Daniela Dietrich; Barbara Johnson; Stephen A Baldwin; Michael J Holdsworth; Frederica L Theodoulou; Alison Baker
The NBDs that wouldn't die: A cautionary tale of the use of isolated nucleotide binding domains of ABC transporters.
Communicative & integrative biology 2009;2(2):97-9.
2009: Georgios Psakis; Massoud Saidijam; Keigo Shibayama; Julia Polaczek; Kim E Bettaney; Jocelyn M Baldwin; Stephen A Baldwin; Ryan Hope; Lars-Oliver Essen; Richard C Essenberg; Peter J F Henderson
The sodium-dependent D-glucose transport protein of Helicobacter pylori.
Molecular microbiology 2009;71(2):391-403.
2009: Adam N Elwi; Vijaya L Damaraju; Michelle L Kuzma; Stephen A Baldwin; James D Young; Michael B Sawyer; Carol E Cass
Human concentrative nucleoside transporter 3 is a determinant of fludarabine transportability and cytotoxicity in human renal proximal tubule cell cultures.
Cancer chemotherapy and pharmacology 2009;63(2):289-301.
2008: Xiaobing Xia; Vincent Postis; Moazur Rahman; Gareth S A Wright; Peter C J Roach; Sarah E Deacon; Jean C Ingram; Peter J F Henderson; John B C Findlay; Simon E V Phillips; Michael J McPherson; Stephen A Baldwin
Investigation of the structure and function of a Shewanella oneidensis arsenical-resistance family transporter.
Molecular membrane biology 2008;25(8):691-705.
2008: Moazur Rahman; Simon G Patching; Fouzia Ismat; Peter J F Henderson; Richard B Herbert; Stephen A Baldwin; Michael J McPherson
Probing metal ion substrate-binding to the E. coli ZitB exporter in native membranes by solid state NMR.
Molecular membrane biology 2008;25(8):683-90.
2008: Sarah E Deacon; Peter C J Roach; Vincent Postis; Gareth S A Wright; Xiaobing Xia; Simon E V Phillips; J Paul Knox; Peter J F Henderson; Michael J McPherson; Stephen A Baldwin
Reliable scale-up of membrane protein over-expression by bacterial auto-induction: from microwell plates to pilot scale fermentations.
Molecular membrane biology 2008;25(8):588-98.
2008: Peter C J Roach; Vincent Postis; Sarah E Deacon; Gareth S A Wright; Jean C Ingram; Xiaobing Xia; Michael J McPherson; Stephen A Baldwin
Large-scale preparation of bacterial cell membranes by tangential flow filtration.
Molecular membrane biology 2008;25(8):609-16.
2008: Vincent Postis; Sarah E Deacon; Peter C J Roach; Gareth S A Wright; Xiaobing Xia; Jean C Ingram; Jonathan M Hadden; Peter J F Henderson; Simon E V Phillips; Michael J McPherson; Stephen A Baldwin
A high-throughput assay of membrane protein stability.
Molecular membrane biology 2008;25(8):617-24.
2008: Melissa D Slugoski; Kyla M Smith; Ras Mulinta; Amy M L Ng; Sylvia Y M Yao; Ellen L Morrison; Queenie O T Lee; Jing Zhang; Edward Karpinski; Carol E Cass; Stephen A Baldwin; James D Young
A conformationally mobile cysteine residue (Cys-561) modulates Na+ and H+ activation of human CNT3.
The Journal of biological chemistry 2008;283(36):24922-34.
2008: Simon G Patching; Georgios Psakis; Stephen A Baldwin; Jocelyn Baldwin; Peter J F Henderson; David A Middleton
Relative substrate affinities of wild-type and mutant forms of the Escherichia coli sugar transporter GalP determined by solid-state NMR.
Molecular membrane biology 2008;25(6-7):474-84.
2008: Robert J Paproski; Frank Visser; Jing Zhang; Tracey Tackaberry; Vijaya Damaraju; Stephen A Baldwin; James D Young; Carol E Cass
Mutation of Trp29 of human equilibrative nucleoside transporter 1 alters affinity for coronary vasodilator drugs and nucleoside selectivity.
The Biochemical journal 2008;414(2):291-300.
2008: James D Young; Sylvia Y M Yao; L Sun; Carol E Cass; Stephen A Baldwin
Human equilibrative nucleoside transporter (ENT) family of nucleoside and nucleobase transporter proteins.
Xenobiotica; the fate of foreign compounds in biological systems 2008;38(7-8):995-1021.
2008: Melissa D Slugoski; Amy M L Ng; Sylvia Y M Yao; Kyla M Smith; Colin C Lin; Jing Zhang; Edward Karpinski; Carol E Cass; Stephen A Baldwin; James D Young
A proton-mediated conformational shift identifies a mobile pore-lining cysteine residue (Cys-561) in human concentrative nucleoside transporter 3.
The Journal of biological chemistry 2008;283(13):8496-507.
2008: Natalya Lukoyanova; Stephen A Baldwin; John Trinick
3D reconstruction of mammalian septin filaments.
Journal of molecular biology 2008;376(1):1-7.
2007: Gerard H M Huysmans; Sheena E Radford; David J Brockwell; Stephen A Baldwin
The N-terminal helix is a post-assembly clamp in the bacterial outer membrane protein PagP.
Journal of molecular biology 2007;373(3):529-40.
2007: Sylvia Y M Yao; Amy M L Ng; Melissa D Slugoski; Kyla M Smith; Ras Mulinta; Edward Karpinski; Carol E Cass; Stephen A Baldwin; James D Young
Conserved glutamate residues are critically involved in Na+/nucleoside cotransport by human concentrative nucleoside transporter 1 (hCNT1).
The Journal of biological chemistry 2007;282(42):30607-17.
2007: Moazur Rahman; Fouzia Ismat; Michael J J McPherson; Stephen A Baldwin
Topology-informed strategies for the overexpression and purification of membrane proteins.
Molecular membrane biology 2007;24(5-6):407-18.
2007: Vijaya L Damaraju; Adam N Elwi; Charlene Hunter; Pat Carpenter; Cheryl Santos; Gerry M Barron; Xuejun Sun; Stephen A Baldwin; James D Young; John R Mackey; Michael B Sawyer; Carol E Cass
Localization of broadly selective equilibrative and concentrative nucleoside transporters, hENT1 and hCNT3, in human kidney.
American journal of physiology. Renal physiology 2007;293(1):F200-11.
2007: Frank Visser; Lijie Sun; Vijaya L Damaraju; Tracey Tackaberry; Yunshan Peng; Morris J Robins; Stephen A Baldwin; James D Young; Carol E Cass
Residues 334 and 338 in transmembrane segment 8 of human equilibrative nucleoside transporter 1 are important determinants of inhibitor sensitivity, protein folding, and catalytic turnover.
The Journal of biological chemistry 2007;282(19):14148-57.
2007: Jing Zhang; Frank Visser; Karen M King; Stephen A Baldwin; James D Young; Carol E Cass
The role of nucleoside transporters in cancer chemotherapy with nucleoside drugs.
Cancer metastasis reviews 2007;26(1):85-110.
2007: Melissa D Slugoski; Shaun K Loewen; Amy M L Ng; Kyla M Smith; Sylvia Y M Yao; Edward Karpinski; Carol E Cass; Stephen A Baldwin; James D Young
Specific mutations in transmembrane helix 8 of human concentrative Na+/nucleoside cotransporter hCNT1 affect permeant selectivity and cation coupling.
Biochemistry 2007;46(6):1684-93.
2007: Kyla M Smith; Melissa D Slugoski; Carol E Cass; Stephen A Baldwin; Edward Karpinski; James D Young
Cation coupling properties of human concentrative nucleoside transporters hCNT1, hCNT2 and hCNT3.
Molecular membrane biology 2007;24(1):53-64.
2007: Stephen A Baldwin; Glenn A McConkey; Carol E Cass; James D Young
Nucleoside transport as a potential target for chemotherapy in malaria.
Current pharmaceutical design 2007;13(6):569-80.
2006: Adam N Elwi; Vijaya L Damaraju; Stephen A Baldwin; James D Young; Michael B Sawyer; Carol E Cass
Renal nucleoside transporters: physiological and clinical implications.
Biochemistry and cell biology = Biochimie et biologie cellulaire 2006;84(6):844-58.
2006: Jing Zhang; Kyla M Smith; Tracey Tackaberry; Xuejun Sun; Pat Carpenter; Melissa D Slugoski; Morris J Robins; Lars P C Nielsen; Ireneusz Nowak; Stephen A Baldwin; James D Young; Carol E Cass
Characterization of the transport mechanism and permeant binding profile of the uridine permease Fui1p of Saccharomyces cerevisiae.
The Journal of biological chemistry 2006;281(38):28210-21.
2006: Kay Barnes; Halina Dobrzynski; Sophie Foppolo; Paul R Beal; Fouzia Ismat; Elspeth R Scullion; Lijie Sun; James Tellez; Mabel W L Ritzel; William C Claycomb; Carol E Cass; James D Young; Rudi Billeter-Clark; Mark R Boyett; Stephen A Baldwin
Distribution and functional characterization of equilibrative nucleoside transporter-4, a novel cardiac adenosine transporter activated at acidic pH.
Circulation research 2006;99(5):510-9.
2006: Anne E King; Michael A Ackley; Carol E Cass; James D Young; Stephen A Baldwin
Nucleoside transporters: from scavengers to novel therapeutic targets.
Trends in pharmacological sciences 2006;27(8):416-25.
2006: Jing Zhang; Tracey Tackaberry; Mabel W L Ritzel; Taylor Raborn; Gerry M Barron; Stephen A Baldwin; James D Young; Carol E Cass
Cysteine-accessibility analysis of transmembrane domains 11-13 of human concentrative nucleoside transporter 3.
The Biochemical journal 2006;394(Pt 2):389-98.
2006: Jing Zhang; Xuejun Sun; Kyla M Smith; Frank Visser; Pat Carpenter; Gerry M Barron; Yunshan Peng; Morris J Robins; Stephen A Baldwin; James D Young; Carol E Cass
Studies of nucleoside transporters using novel autofluorescent nucleoside probes.
Biochemistry 2006;45(4):1087-98.
2005: Ricardo J M Governo; Jim Deuchars; Stephen A Baldwin; Anne E King
Localization of the NBMPR-sensitive equilibrative nucleoside transporter, ENT1, in the rat dorsal root ganglion and lumbar spinal cord.
Brain research 2005;1059(2):129-38.
2005: Jing Zhang; Kyla M Smith; Tracey Tackaberry; Frank Visser; Morris J Robins; Lars P C Nielsen; Ireneusz Nowak; Edward Karpinski; Stephen A Baldwin; James D Young; Carol E Cass
Uridine binding and transportability determinants of human concentrative nucleoside transporters.
Molecular pharmacology 2005;68(3):830-9.
2005: Kyla M Smith; Melissa D Slugoski; Shaun K Loewen; Amy M L Ng; Sylvia Y M Yao; Xing-Zhen Chen; Edward Karpinski; Carol E Cass; Stephen A Baldwin; James D Young
The broadly selective human Na+/nucleoside cotransporter (hCNT3) exhibits novel cation-coupled nucleoside transport characteristics.
The Journal of biological chemistry 2005;280(27):25436-49.
2005: Kay Barnes; Elizabeth McIntosh; Anthony D Whetton; George Q Daley; Johanne Bentley; Stephen A Baldwin
Chronic myeloid leukaemia: an investigation into the role of Bcr-Abl-induced abnormalities in glucose transport regulation.
Oncogene 2005;24(20):3257-67.
2005: Stephen A Baldwin; Sylvia Y M Yao; Ralph J Hyde; Amy M L Ng; Sophie Foppolo; Kay Barnes; Mabel W L Ritzel; Carol E Cass; James D Young
Functional characterization of novel human and mouse equilibrative nucleoside transporters (hENT3 and mENT3) located in intracellular membranes.
The Journal of biological chemistry 2005;280(16):15880-7.
2005: Frank Visser; Jing Zhang; R Taylor Raborn; Stephen A Baldwin; James D Young; Carol E Cass
Residue 33 of human equilibrative nucleoside transporter 2 is a functionally important component of both the dipyridamole and nucleoside binding sites.
Molecular pharmacology 2005;67(4):1291-8.
2005: Frank Visser; Stephen A Baldwin; R Elwyn Isaac; James D Young; Carol E Cass
Identification and mutational analysis of amino acid residues involved in dipyridamole interactions with human and Caenorhabditis elegans equilibrative nucleoside transporters.
The Journal of biological chemistry 2005;280(12):11025-34.
2005: Michael A Ackley; Stephen A Baldwin; Anne E King
Adenosine contributes to mu-opioid synaptic inhibition in rat substantia gelatinosa in vitro.
Neuroscience letters 2005;376(2):102-6.
2005: Sambasivarao Damaraju; Jing Zhang; Frank Visser; Tracey Tackaberry; Jennifer Dufour; Kyla M Smith; Melissa D Slugoski; Mabel W L Ritzel; Stephen A Baldwin; James D Young; Carol E Cass
Identification and functional characterization of variants in human concentrative nucleoside transporter 3, hCNT3 (SLC28A3), arising from single nucleotide polymorphisms in coding regions of the hCNT3 gene.
Pharmacogenetics and genomics 2005;15(3):173-82.
2005: Simon G Patching; Stephen A Baldwin; Alexander D Baldwin; James D Young; Maurice P Gallagher; Peter J F Henderson; Richard B Herbert
The nucleoside transport proteins, NupC and NupG, from Escherichia coli: specific structural motifs necessary for the binding of ligands.
Organic & biomolecular chemistry 2005;3(3):462-70.
2004: Melissa D Slugoski; Shaun K Loewen; Amy M L Ng; Stephen A Baldwin; Carol E Cass; James D Young
Allelic isoforms of the H+/nucleoside co-transporter (CaCNT) from Candida albicans reveal separate high- and low-affinity transport systems for nucleosides.
Yeast (Chichester, England) 2004;21(15):1269-77.
2004: Hao Xie; Simon G Patching; Maurice P Gallagher; Gary J Litherland; Adrian R Brough; Henrietta Venter; Sylvia Y M Yao; Amy M L Ng; James D Young; Richard B Herbert; Peter J F Henderson; Stephen A Baldwin
Purification and properties of the Escherichia coli nucleoside transporter NupG, a paradigm for a major facilitator transporter sub-family.
Molecular membrane biology 2004;21(5):323-36.
2004: Kyla M Smith; Amy M L Ng; Sylvia Y M Yao; Kathy A Labedz; Edward E Knaus; Leonard I Wiebe; Carol E Cass; Stephen A Baldwin; Xing-Zhen Chen; Edward Karpinski; James D Young
Electrophysiological characterization of a recombinant human Na+-coupled nucleoside transporter (hCNT1) produced in Xenopus oocytes.
The Journal of physiology 2004;558(Pt 3):807-23.
2004: Peter J Appleford; Mark Griffiths; Sylvia Y M Yao; Amy M L Ng; Eugene G Chomey; R Elwyn Isaac; David Coates; Ian A Hope; Carol E Cass; James D Young; Stephen A Baldwin
Functional redundancy of two nucleoside transporters of the ENT family (CeENT1, CeENT2) required for development of Caenorhabditis elegans.
Molecular membrane biology 2004;21(4):247-59.
2004: Kay Barnes; Jean C Ingram; Matthew D M Bennett; Gordon W Stewart; Stephen A Baldwin
Methyl-beta-cyclodextrin stimulates glucose uptake in Clone 9 cells: a possible role for lipid rafts.
The Biochemical journal 2004;378(Pt 2):343-51.
2004: Stephen A Baldwin; Paul R Beal; Sylvia Y M Yao; Anne E King; Carol E Cass; James D Young
The equilibrative nucleoside transporter family, SLC29.
Pflügers Archiv : European journal of physiology 2004;447(5):735-43.
2004: Mark F Vickers; Jing Zhang; Frank Visser; Tracey Tackaberry; Morris J Robins; Lars P C Nielsen; Ireneusz Nowak; Stephen A Baldwin; James D Young; Carol E Cass
Uridine recognition motifs of human equilibrative nucleoside transporters 1 and 2 produced in Saccharomyces cerevisiae.
Nucleosides, nucleotides & nucleic acids 2004;23(1-2):361-73.
2004: Shaun K Loewen; Sylvia Y M Yao; Melissa D Slugoski; Nadira N Mohabir; Raymond J Turner; John R Mackey; Joel Weiner; Maurice P Gallagher; Peter J F Henderson; Stephen A Baldwin; Carol E Cass; James D Young
Transport of physiological nucleosides and anti-viral and anti-neoplastic nucleoside drugs by recombinant Escherichia coli nucleoside-H(+) cotransporter (NupC) produced in Xenopus laevis oocytes.
Molecular membrane biology 2004;21(1):1-10.
2003: Jing Zhang; Frank Visser; Mark F Vickers; Thack Lang; Morris J Robins; Lars P C Nielsen; Ireneusz Nowak; Stephen A Baldwin; James D Young; Carol E Cass
Uridine binding motifs of human concentrative nucleoside transporters 1 and 3 produced in Saccharomyces cerevisiae.
Molecular pharmacology 2003;64(6):1512-20.
2003: Vijaya L Damaraju; Sambasivarao Damaraju; James D Young; Stephen A Baldwin; John Mackey; Michael B Sawyer; Carol E Cass
Nucleoside anticancer drugs: the role of nucleoside transporters in resistance to cancer chemotherapy.
Oncogene 2003;22(47):7524-36.
2003: Johanne Bentley; Dalina Itchayanan; Kay Barnes; Elizabeth McIntosh; Xiuwen Tang; C Peter Downes; Geoffrey D Holman; Anthony D Whetton; P Jane Owen-Lynch; Stephen A Baldwin
Interleukin-3-mediated cell survival signals include phosphatidylinositol 3-kinase-dependent translocation of the glucose transporter GLUT1 to the cell surface.
The Journal of biological chemistry 2003;278(41):39337-48.
2003: Shaun K Loewen; Amy M L Ng; Nadira N Mohabir; Stephen A Baldwin; Carol E Cass; James D Young
Functional characterization of a H+/nucleoside co-transporter (CaCNT) from Candida albicans, a fungal member of the concentrative nucleoside transporter (CNT) family of membrane proteins.
Yeast (Chichester, England) 2003;20(8):661-75.
2003: Michael A Ackley; Ricardo J M Governo; Carol E Cass; James D Young; Stephen A Baldwin; Anne E King
Control of glutamatergic neurotransmission in the rat spinal dorsal horn by the nucleoside transporter ENT1.
The Journal of physiology 2003;548(Pt 2):507-17.
2003: Sreenivasan Ponnambalam; Stephen A Baldwin
Constitutive protein secretion from the trans-Golgi network to the plasma membrane.
Molecular membrane biology 2003;20(2):129-39.
2003: Artur J Szkotak; Amy M L Ng; S F Paul Man; Stephen A Baldwin; Carol E Cass; James D Young; Marek Duszyk
Coupling of CFTR-mediated anion secretion to nucleoside transporters and adenosine homeostasis in Calu-3 cells.
The Journal of membrane biology 2003;192(3):169-79.
2002: Sylvia Y M Yao; Amy M L Ng; Mark F Vickers; Manickavasagam Sundaram; Carol E Cass; Stephen A Baldwin; James D Young
Functional and molecular characterization of nucleobase transport by recombinant human and rat equilibrative nucleoside transporters 1 and 2. Chimeric constructs reveal a role for the ENT2 helix 5-6 region in nucleobase translocation.
The Journal of biological chemistry 2002;277(28):24938-48.
2002: Tony Reiman; Marilyn Lesley Clarke; Laith Dabbagh; Michaela Vsianska; Robert W Coupland; Andrew R Belch; Stephen A Baldwin; James D Young; Carol E Cass; John R Mackey
Differential expression of human equilibrative nucleoside transporter 1 (hENT1) protein in the Reed-Sternberg cells of Hodgkin's disease.
Leukemia & lymphoma 2002;43(7):1435-40.
2002: Sylvia Y M Yao; Amy M L Ng; Shaun K Loewen; Carol E Cass; Stephen A Baldwin; James D Young
An ancient prevertebrate Na+-nucleoside cotransporter (hfCNT) from the Pacific hagfish (Eptatretus stouti).
American journal of physiology. Cell physiology 2002;283(1):C155-68.
2002: Kay Barnes; Jean C Ingram; Omar H Porras; Luis Felipe Barros; Emma R Hudson; Lee G D Fryer; Fabienne Foufelle; David Carling; D Grahame Hardie; Stephen A Baldwin
Activation of GLUT1 by metabolic and osmotic stress: potential involvement of AMP-activated protein kinase (AMPK).
Journal of cell science 2002;115(Pt 11):2433-42.
2002: Lee G D Fryer; Fabienne Foufelle; Kay Barnes; Stephen A Baldwin; Angela Woods; David Carling
Characterization of the role of the AMP-activated protein kinase in the stimulation of glucose transport in skeletal muscle cells.
The Biochemical journal 2002;363(Pt 1):167-74.
2002: Hanny Musa; Halina Dobrzynski; Z Berry; Fatima Abidi; Carol E Cass; James D Young; Stephen A Baldwin; Mark R Boyett
Immunocytochemical demonstration of the equilibrative nucleoside transporter rENT1 in rat sinoatrial node.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2002;50(3):305-9.
2002: Frank Visser; Mark F Vickers; Amy M L Ng; Stephen A Baldwin; James D Young; Carol E Cass
Mutation of residue 33 of human equilibrative nucleoside transporters 1 and 2 alters sensitivity to inhibition of transport by dilazep and dipyridamole.
The Journal of biological chemistry 2002;277(1):395-401.
2002: Marilyn Lesley Clarke; John R Mackey; Stephen A Baldwin; James D Young; Carol E Cass
The role of membrane transporters in cellular resistance to anticancer nucleoside drugs.
Cancer treatment and research 2002;112():27-47.
2002: Mark F Vickers; Rakesh Kumar; Frank Visser; Jing Zhang; Jahangir Charania; R Taylor Raborn; Stephen A Baldwin; James D Young; Carol E Cass
Comparison of the interaction of uridine, cytidine, and other pyrimidine nucleoside analogues with recombinant human equilibrative nucleoside transporter 2 (hENT2) produced in Saccharomyces cerevisiae.
Biochemistry and cell biology = Biochimie et biologie cellulaire 2002;80(5):639-44.
2002: Miguel A Cabrita; Stephen A Baldwin; James D Young; Carol E Cass
Molecular biology and regulation of nucleoside and nucleobase transporter proteins in eukaryotes and prokaryotes.
Biochemistry and cell biology = Biochimie et biologie cellulaire 2002;80(5):623-38.
2002: John R Mackey; Lori L Jennings; Marilyn Lesley Clarke; Cheryl L Santos; Laith Dabbagh; Michaela Vsianska; Sheryl L Koski; Robert W Coupland; Stephen A Baldwin; James D Young; Carol E Cass
Immunohistochemical variation of human equilibrative nucleoside transporter 1 protein in primary breast cancers.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(1):110-6.
2001: Artur J Szkotak; Amy M L Ng; Jolanta Sawicka; Stephen A Baldwin; S F Paul Man; Carol E Cass; James D Young; Marek Duszyk
Regulation of K(+) current in human airway epithelial cells by exogenous and autocrine adenosine.
American journal of physiology. Cell physiology 2001;281(6):C1991-2002.
2001: Manickavasagam Sundaram; Sylvia Y M Yao; Jean C Ingram; Z A Berry; Fatima Abidi; Carol E Cass; Stephen A Baldwin; James D Young
Topology of a human equilibrative, nitrobenzylthioinosine (NBMPR)-sensitive nucleoside transporter (hENT1) implicated in the cellular uptake of adenosine and anti-cancer drugs.
The Journal of biological chemistry 2001;276(48):45270-5.
2001: S R Hamilton; Sylvia Y M Yao; Jean C Ingram; D A Hadden; Mabel W L Ritzel; Maurice P Gallagher; Peter J F Henderson; Carol E Cass; James D Young; Stephen A Baldwin
Subcellular distribution and membrane topology of the mammalian concentrative Na+-nucleoside cotransporter rCNT1.
The Journal of biological chemistry 2001;276(30):27981-8.
2001: Manickavasagam Sundaram; Sylvia Y M Yao; Amy M L Ng; Carol E Cass; Stephen A Baldwin; James D Young
Equilibrative nucleoside transporters: mapping regions of interaction for the substrate analogue nitrobenzylthioinosine (NBMPR) using rat chimeric proteins.
Biochemistry 2001;40(27):8146-51.
2001: Luis Felipe Barros; Kay Barnes; Jean C Ingram; Joel castro; Omar H Porras; Stephen A Baldwin
Hyperosmotic shock induces both activation and translocation of glucose transporters in mammalian cells.
Pflügers Archiv : European journal of physiology 2001;442(4):614-21.
2001: Sylvia Y M Yao; Amy M L Ng; Manickavasagam Sundaram; Carol E Cass; Stephen A Baldwin; James D Young
Transport of antiviral 3'-deoxy-nucleoside drugs by recombinant human and rat equilibrative, nitrobenzylthioinosine (NBMPR)-insensitive (ENT2) nucleoside transporter proteins produced in Xenopus oocytes.
Molecular membrane biology 2001;18(2):161-7.
2001: Lori L Jennings; C Hao; Miguel A Cabrita; Mark F Vickers; Stephen A Baldwin; James D Young; Carol E Cass
Distinct regional distribution of human equilibrative nucleoside transporter proteins 1 and 2 (hENT1 and hENT2) in the central nervous system.
Neuropharmacology 2001;40(5):722-31.
2001: Mabel W L Ritzel; Amy M L Ng; Sylvia Y M Yao; K Graham; Shaun K Loewen; Kyla M Smith; R Gary Ritzel; Delores Mowles; Pat Carpenter; Xing-Zhen Chen; Edward Karpinski; Ralph J Hyde; Stephen A Baldwin; Carol E Cass; James D Young
Molecular identification and characterization of novel human and mouse concentrative Na+-nucleoside cotransporter proteins (hCNT3 and mCNT3) broadly selective for purine and pyrimidine nucleosides (system cib).
The Journal of biological chemistry 2001;276(4):2914-27.
2001: Sylvia Y M Yao; Manickavasagam Sundaram; Eugene G Chomey; Carol E Cass; Stephen A Baldwin; James D Young
Identification of Cys140 in helix 4 as an exofacial cysteine residue within the substrate-translocation channel of rat equilibrative nitrobenzylthioinosine (NBMPR)-insensitive nucleoside transporter rENT2.
The Biochemical journal 2001;353(Pt 2):387-93.
2001: Mark F Vickers; James D Young; Stephen A Baldwin; Michael J Ellison; Carol E Cass
Functional production of mammalian concentrative nucleoside transporters in Saccharomyces cerevisiae.
Molecular membrane biology 2001;18(1):73-9.
2001: Mabel W L Ritzel; Amy M L Ng; Sylvia Y M Yao; K Graham; Shaun K Loewen; Kyla M Smith; Ralph J Hyde; Edward Karpinski; Carol E Cass; Stephen A Baldwin; James D Young
Recent molecular advances in studies of the concentrative Na+-dependent nucleoside transporter (CNT) family: identification and characterization of novel human and mouse proteins (hCNT3 and mCNT3) broadly selective for purine and pyrimidine nucleosides (system cib).
Molecular membrane biology 2001;18(1):65-72.
2001: Ralph J Hyde; Carol E Cass; James D Young; Stephen A Baldwin
The ENT family of eukaryote nucleoside and nucleobase transporters: recent advances in the investigation of structure/function relationships and the identification of novel isoforms.
Molecular membrane biology 2001;18(1):53-63.
2001: Johanne Bentley; Ian Walker; Elizabeth McIntosh; Anthony D Whetton; P Jane Owen-Lynch; Stephen A Baldwin
Glucose transport regulation by p210 Bcr-Abl in a chronic myeloid leukaemia model.
British journal of haematology 2001;112(1):212-5.
2000: Mark F Vickers; Sylvia Y M Yao; Stephen A Baldwin; James D Young; Carol E Cass
Nucleoside transporter proteins of Saccharomyces cerevisiae. Demonstration of a transporter (FUI1) with high uridine selectivity in plasma membranes and a transporter (FUN26) with broad nucleoside selectivity in intracellular membranes.
The Journal of biological chemistry 2000;275(34):25931-8.
2000: M D Parker; Ralph J Hyde; Sylvia Y M Yao; Louisa McRobert; Carol E Cass; James D Young; Glenn A McConkey; Stephen A Baldwin
Identification of a nucleoside/nucleobase transporter from Plasmodium falciparum, a novel target for anti-malarial chemotherapy.
The Biochemical journal 2000;349(Pt 1):67-75.
1999: John R Mackey; Sylvia Y M Yao; Kyla M Smith; Edward Karpinski; Stephen A Baldwin; Carol E Cass; James D Young
Gemcitabine transport in xenopus oocytes expressing recombinant plasma membrane mammalian nucleoside transporters.
Journal of the National Cancer Institute 1999;91(21):1876-81.
1999: Shaun K Loewen; Amy M L Ng; Sylvia Y M Yao; Carol E Cass; Stephen A Baldwin; James D Young
Identification of amino acid residues responsible for the pyrimidine and purine nucleoside specificities of human concentrative Na(+) nucleoside cotransporters hCNT1 and hCNT2.
The Journal of biological chemistry 1999;274(35):24475-84.
1999: Stephen A Baldwin; J R Mackey; Carol E Cass; James D Young
Nucleoside transporters: molecular biology and implications for therapeutic development.
Molecular medicine today 1999;5(5):216-24.
1999: Mark F Vickers; Rajam S Mani; Manickavasagam Sundaram; Douglas L Hogue; James D Young; Stephen A Baldwin; Carol E Cass
Functional production and reconstitution of the human equilibrative nucleoside transporter (hENT1) in Saccharomyces cerevisiae. Interaction of inhibitors of nucleoside transport with recombinant hENT1 and a glycosylation-defective derivative (hENT1/N48Q).
The Biochemical journal 1999;339 ( Pt 1)():21-32.
1999: Carol E Cass; James D Young; Stephen A Baldwin; Miguel A Cabrita; Kathryn A Graham; Mark Griffiths; Lori L Jennings; John R Mackey; Amy M L Ng; Mabel W L Ritzel; Mark F Vickers; Sylvia Y M Yao
Nucleoside transporters of mammalian cells.
Pharmaceutical biotechnology 1999;12():313-52.
1998: Rajam S Mani; J R Hammond; J M Marjan; Kathryn A Graham; James D Young; Stephen A Baldwin; Carol E Cass
Demonstration of equilibrative nucleoside transporters (hENT1 and hENT2) in nuclear envelopes of cultured human choriocarcinoma (BeWo) cells by functional reconstitution in proteoliposomes.
The Journal of biological chemistry 1998;273(46):30818-25.
1998: Manickavasagam Sundaram; Sylvia Y M Yao; Amy M L Ng; Mark Griffiths; Carol E Cass; Stephen A Baldwin; James D Young
Chimeric constructs between human and rat equilibrative nucleoside transporters (hENT1 and rENT1) reveal hENT1 structural domains interacting with coronary vasoactive drugs.
The Journal of biological chemistry 1998;273(34):21519-25.
1998: Carol E Cass; James D Young; Stephen A Baldwin
Recent advances in the molecular biology of nucleoside transporters of mammalian cells.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1998;76(5):761-70.
1997: Mark Griffiths; Sylvia Y M Yao; Fatima Abidi; Simon E V Phillips; Carol E Cass; James D Young; Stephen A Baldwin
Molecular cloning and characterization of a nitrobenzylthioinosine-insensitive (ei) equilibrative nucleoside transporter from human placenta.
The Biochemical journal 1997;328 ( Pt 3)():739-43.
1997: Sylvia Y M Yao; Amy M L Ng; WR Muzyka; Mark Griffiths; Carol E Cass; Stephen A Baldwin; James D Young
Molecular cloning and functional characterization of nitrobenzylthioinosine (NBMPR)-sensitive (es) and NBMPR-insensitive (ei) equilibrative nucleoside transporter proteins (rENT1 and rENT2) from rat tissues.
The Journal of biological chemistry 1997;272(45):28423-30.
1997: Luis Felipe Barros; M Young; J Saklatvala; Stephen A Baldwin
Evidence of two mechanisms for the activation of the glucose transporter GLUT1 by anisomycin: p38(MAP kinase) activation and protein synthesis inhibition in mammalian cells.
The Journal of physiology 1997;504 ( Pt 3)():517-25.
1997: IR Coe; Mark Griffiths; James D Young; Stephen A Baldwin; Carol E Cass
Assignment of the human equilibrative nucleoside transporter (hENT1) to 6p21.1-p21.2.
Genomics 1997;45(2):459-60.
1997: H Boleti; IR Coe; Stephen A Baldwin; James D Young; Carol E Cass
Molecular identification of the equilibrative NBMPR-sensitive (es) nucleoside transporter and demonstration of an equilibrative NBMPR-insensitive (ei) transport activity in human erythroleukemia (K562) cells.
Neuropharmacology 1997;36(9):1167-79.
1997: Luis Felipe Barros; Stephen A Baldwin; M Griffiths
Rapid activation of GLUT1 by osmotic stress.
Biochemical Society transactions 1997;25(3):485S.
1997: E R Hudson; L S MA; C J Wilde; D J Flint; Stephen A Baldwin
Regulation of GLUT1 expression in the mammary gland.
Biochemical Society transactions 1997;25(3):464S.
1997: C H Simons; A B Weinglass; Stephen A Baldwin
Studies on the expression of the human erythrocyte glucose transporter (GLUT1) in the yeast Saccharomyces cerevisiae.
Biochemical Society transactions 1997;25(3):463S.
1997: Stephen A Baldwin; Luis Felipe Barros; M Griffiths; Joanne Ingram; E C Robbins; A J Streets; J Saklatvala
Regulation of GLUT1 in response to cellular stress.
Biochemical Society transactions 1997;25(3):954-8.
1997: Mark Griffiths; Nick Beaumont; Sylvia Y M Yao; M Sundaram; C E Boumah; A Davies; F Y Kwong; I Coe; Carol E Cass; James D Young; Stephen A Baldwin
Cloning of a human nucleoside transporter implicated in the cellular uptake of adenosine and chemotherapeutic drugs.
Nature medicine 1997;3(1):89-93.
1996: S Boyer; P A Sharp; Edward S Debnam; Stephen A Baldwin; Kaila Surjit Srai
Streptozotocin diabetes and the expression of GLUT1 at the brush border and basolateral membranes of intestinal enterocytes.
FEBS letters 1996;396(2-3):218-22.
1996: A B Weinglass; Stephen A Baldwin
Characterisation and purification of recombinant GLUT1 expressed in insect cells.
Biochemical Society transactions 1996;24(3):478S.
1995: Stephen A Baldwin; Luis Felipe Barros; M Griffiths
Trafficking of glucose transporters--signals and mechanisms.
Bioscience reports 1995;15(6):419-26.
1995: Luis Felipe Barros; D L Yudilevich; S M Jarvis; N Beaumont; Stephen A Baldwin
Quantitation and immunolocalization of glucose transporters in the human placenta.
Placenta 1995;16(7):623-33.
1995: Luis Felipe Barros; N Van den Berghe; G Nixon; M Griffiths; M Van Mackelenbergh; J Ingram; Stephen A Baldwin
Candidate proteins involved in the targeting of the insulin-sensitive glucose transporter GLUT4 in adipocytes.
Biochemical Society transactions 1995;23(3):414S.
1995: Luis Felipe Barros; R B Marchant; Stephen A Baldwin
Dissection of stress-activated glucose transport from insulin-induced glucose transport in mammalian cells using wortmannin and ML-9.
The Biochemical journal 1995;309 ( Pt 3)():731-6.
1995: Luis Felipe Barros; D L Yudilevich; S M Jarvis; N Beaumont; James D Young; Stephen A Baldwin
Immunolocalisation of nucleoside transporters in human placental trophoblast and endothelial cells: evidence for multiple transporter isoforms.
Pflügers Archiv : European journal of physiology 1995;429(3):394-9.
1994: O Kan; Stephen A Baldwin; Anthony D Whetton
Apoptosis is regulated by the rate of glucose transport in an interleukin 3 dependent cell line.
The Journal of experimental medicine 1994;180(3):917-23.
1994: Stephen A Baldwin; O Kan; Anthony D Whetton; Sally Martin; H A Fawcett; D J Flint; C J Wilde
Regulation of the glucose transporter GLUT1 in mammalian cells.
Biochemical Society transactions 1994;22(3):814-7.
1994: R A Preston; A J Sami; B M Charalambous; Stephen A Baldwin
Production of functional GLUT1 by co-expression of N- and C-terminal half molecules in Xenopus oocytes.
Biochemical Society transactions 1994;22(3):276S.
1994: O Kan; Stephen A Baldwin; Anthony D Whetton
Apoptosis is regulated by the rate of glucose transport in an IL-3-dependent haemopoietic cell line.
Biochemical Society transactions 1994;22(3):275S.
1994: C E Boumah; C M Harvey; Alan R P Paterson; Stephen A Baldwin; James D Young; C E Cass
Functional expression of the nitrobenzylthioinosine-sensitive nucleoside transporter of human choriocarcinoma (BeWo) cells in isolated oocytes of Xenopus laevis.
The Biochemical journal 1994;299 ( Pt 3)():769-73.
1993: F Y Kwong; J S Wu; M M Shi; H E Fincham; A Davies; P J Henderson; Stephen A Baldwin; James D Young
Enzymic cleavage as a probe of the molecular structures of mammalian equilibrative nucleoside transporters.
The Journal of biological chemistry 1993;268(29):22127-34.
1993: Stephen A Baldwin
Mammalian passive glucose transporters: members of an ubiquitous family of active and passive transport proteins.
Biochimica et biophysica acta 1993;1154(1):17-49.
1993: R A Preston; Stephen A Baldwin
GLUT 1: identification of exofacial lysine-residues.
Biochemical Society transactions 1993;21(2):309-12.
1992: F Y Kwong; H E Fincham; A Davies; N Beaumont; P J Henderson; James D Young; Stephen A Baldwin
Mammalian nitrobenzylthioinosine-sensitive nucleoside transport proteins. Immunological evidence that transporters differing in size and inhibitor specificity share sequence homology.
The Journal of biological chemistry 1992;267(30):21954-60.
1992: Stephen A Baldwin
Probing the structure and function of the human erythrocyte glucose transporter.
Biochemical Society transactions 1992;20(3):533-7.
1992: Luis Felipe Barros; N Beaumont; S M Jarvis; James D Young; P J Henderson; D L Yudilevich; C Thrasivoulou; Stephen A Baldwin
Nucleoside transporters in human placenta.
Biochemical Society transactions 1992;20(3):244S.
1991: F Y Kwong; H E Fincham; A Davies; P J Henderson; Stephen A Baldwin; James D Young
Antibodies and proteases as probes of the structures of mammalian nucleoside transporters.
Advances in experimental medicine and biology 1991;309A():427-30.
1990: R J Madon; Sally Martin; A Davies; H A Fawcett; David J Flint; Stephen A Baldwin
Identification and characterization of glucose transport proteins in plasma membrane- and Golgi vesicle-enriched fractions prepared from lactating rat mammary gland.
The Biochemical journal 1990;272(1):99-105.
1990: Sally Martin; A Davies; H A Fawcett; R J Madon; David J Flint; Stephen A Baldwin
Characterization of glucose transporters in lactating rat mammary glands.
Biochemical Society transactions 1990;18(4):618-9.
1989: R J Madon; David J Flint; A Davies; Stephen A Baldwin
Identification of glucose transporters in plasma membrane and Golgi vesicle fractions prepared from lactating rat mammary gland.
Biochemical Society transactions 1989;17(3):450-1.
1988: A F Gibbs; D Chapman; Stephen A Baldwin
Proteolytic dissection as a probe of conformational changes in the human erythrocyte glucose transport protein.
The Biochemical journal 1988;256(2):421-7.
1988: F Y Kwong; A Davies; Chung-Ming Tse; James D Young; P J Henderson; Stephen A Baldwin
Purification of the human erythrocyte nucleoside transporter by immunoaffinity chromatography.
The Biochemical journal 1988;255(1):243-9.
1987: M T Cairns; J Alvarez; M Panico; A F Gibbs; H R Morris; D Chapman; Stephen A Baldwin
Investigation of the structure and function of the human erythrocyte glucose transporter by proteolytic dissection.
Biochimica et biophysica acta 1987;905(2):295-310.
1987: M A Kasanicki; M T Cairns; A Davies; R M Gardiner; Stephen A Baldwin
Identification and characterization of the glucose-transport protein of the bovine blood/brain barrier.
The Biochemical journal 1987;247(1):101-8.
1986: F Y Kwong; Stephen A Baldwin; P R Scudder; S M Jarvis; M Y Choy; James D Young
Erythrocyte nucleoside and sugar transport. Endo-beta-galactosidase and endoglycosidase-F digestion of partially purified human and pig transporter proteins.
The Biochemical journal 1986;240(2):349-56.