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Panos Kourounakis

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TOP 3
Eleni A Rekka; Panos N Kourounakis
Medicinal chemistry of 2,2,4-substituted morpholines.
Karyofyllis Tsiakitzis; Eleni A Rekka; Angeliki P Kourounakis; Panos N Kourounakis
Novel compounds designed as antistress agents.
Angeliki P Kourounakis; Christos Charitos; Eleni A Rekka; Panos N Kourounakis
Lipid-lowering (hetero)aromatic tetrahydro-1,4-oxazine derivatives with antioxidant and squalene synthase inhibitory activity.

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All Publications

2010: Eleni A Rekka; Panos N Kourounakis
Medicinal chemistry of 2,2,4-substituted morpholines.
Current medicinal chemistry 2010;17(29):3422-30.
2009: Karyofyllis Tsiakitzis; Eleni A Rekka; Angeliki P Kourounakis; Panos N Kourounakis
Novel compounds designed as antistress agents.
Journal of medicinal chemistry 2009;52(22):7315-8.
2008: Angeliki P Kourounakis; Christos Charitos; Eleni A Rekka; Panos N Kourounakis
Lipid-lowering (hetero)aromatic tetrahydro-1,4-oxazine derivatives with antioxidant and squalene synthase inhibitory activity.
Journal of medicinal chemistry 2008;51(18):5861-5.
2008: Anna Tavridou; Loukas Kaklamanis; Apostolos Papalois; Angeliki P Kourounakis; Eleni A Rekka; Panos N Kourounakis; Avgui Charalambous; Vangelis G Manolopoulos
Antiatherosclerotic properties of EP2302, a novel squalene synthase inhibitor, in the cholesterol-fed rabbit.
Journal of cardiovascular pharmacology 2008;51(6):573-80.
2007: Anna Tavridou; Loukas Kaklamanis; Apostolos Papalois; Angeliki P Kourounakis; Eleni A Rekka; Panos N Kourounakis; Avgui Charalambous; Vangelis G Manolopoulos
EP2306 [2-(4-biphenyl)-4-methyl-octahydro-1,4-benzoxazin-2-ol, hydrobromide], a novel squalene synthase inhibitor, reduces atherosclerosis in the cholesterol-fed rabbit.
The Journal of pharmacology and experimental therapeutics 2007;323(3):794-804.
2007: Ioanna C Siskou; Eleni A Rekka; Angeliki P Kourounakis; Michael C Chrysselis; Karyofyllis Tsiakitzis; Panos N Kourounakis
Design and study of some novel ibuprofen derivatives with potential nootropic and neuroprotective properties.
Bioorganic & medicinal chemistry 2007;15(2):951-61.
2006: George N Ziakas; Eleni A Rekka; Antonios M Gavalas; Phaedra T Eleftheriou; Panos N Kourounakis
New analogues of butylated hydroxytoluene as anti-inflammatory and antioxidant agents.
Bioorganic & medicinal chemistry 2006;14(16):5616-24.
2006: Anna Tavridou; Loukas Kaklamanis; George Megaritis; Angeliki P Kourounakis; Apostolos Papalois; Dimitris Roukounas; Eleni A Rekka; Panos N Kourounakis; Avgui Charalambous; Vangelis G Manolopoulos
Pharmacological characterization in vitro of EP2306 and EP2302, potent inhibitors of squalene synthase and lipid biosynthesis.
European journal of pharmacology 2006;535(1-3):34-42.
2006: Christos M Doulgkeris; Dimitrios Galanakis; Angeliki P Kourounakis; Karyofyllis Tsiakitzis; Antonios M Gavalas; Phaedra T Eleftheriou; Panayiotis Victoratos; Eleni A Rekka; Panos N Kourounakis
Synthesis and pharmacochemical study of novel polyfunctional molecules combining anti-inflammatory, antioxidant, and hypocholesterolemic properties.
Bioorganic & medicinal chemistry letters 2006;16(4):825-9.
2005: George N Ziakas; Eleni A Rekka; Antonios M Gavalas; Phaedra T Eleftheriou; Karyofyllis Tsiakitzis; Panos N Kourounakis
Nitric oxide releasing derivatives of tolfenamic acid with anti-inflammatory activity and safe gastrointestinal profile.
Bioorganic & medicinal chemistry 2005;13(23):6485-92.
2005: Eleni A Rekka; Angeliki P Kourounakis; N Avramidis; Panos N Kourounakis
Effect of some biologically interesting substituted tetrahydro-1,4-oxazines on drug metabolising enzymes and on inflammation.
Current drug metabolism 2005;6(5):481-5.
2005: Karyofyllis Tsiakitzis; Angeliki P Kourounakis; Ekaterini Tani; Eleni A Rekka; Panos N Kourounakis
Stress and active oxygen species--effect of alpha-tocopherol on stress response.
Archiv der Pharmazie 2005;338(7):315-21.
2004: Maria Koufaki; Anastasia Detsi; Elissavet Theodorou; Christina Kiziridi; Theodora Calogeropoulou; Athanasios Vassilopoulos; Angeliki P Kourounakis; Eleni A Rekka; Panos N Kourounakis; Catherine Gaitanaki; Panagiota Papazafiri
Synthesis of chroman analogues of lipoic acid and evaluation of their activity against reperfusion arrhythmias.
Bioorganic & medicinal chemistry 2004;12(18):4835-41.
2004: Dimitrios Galanakis; Angeliki P Kourounakis; Karyofyllis Tsiakitzis; Christos Doulgkeris; Eleni A Rekka; Antonios M Gavalas; Constantina Kravaritou; Christos Charitos; Panos N Kourounakis
Synthesis and pharmacological evaluation of amide conjugates of NSAIDs with L-cysteine ethyl ester, combining potent antiinflammatory and antioxidant properties with significantly reduced gastrointestinal toxicity.
Bioorganic & medicinal chemistry letters 2004;14(14):3639-43.
2004: Ioannis Leventis; Ioanna Andreadou; Apostolos Papalois; Ioannis Sfiniadakis; Vassilis G Gorgoulis; Dimitris P Korkolis; Dimitra Hadjipavlou-Litina; Panos N Kourounakis; Constantine I Fotiadis
A novel antioxidant non-steroidal anti-inflammatory agent protects rat liver against ischemia-reperfusion injury.
In vivo (Athens, Greece) 2004;18(2):161-9.
2003: Nikoletta J Xanthopoulou; Angeliki P Kourounakis; Spyros Spyroudis; Panos N Kourounakis
Synthesis and activity on free radical processes and inflammation of 9,10-dihydro-5,8-dimethoxy-triptycene-quinones.
European journal of medicinal chemistry 2003;38(6):621-6.
2003: Dimitrios Poussios; Ioanna Andreadou; Apostolos Papalois; Eleni A Rekka; Nikolaos Gavalakis; Kyriaki Aroni; Panos N Kourounakis; Constantine I Fotiadis; Michael N Sechas
Protective effect of a novel antioxidant non-steroidal anti-inflammatory agent (compound IA) on intestinal viability after acute mesenteric ischemia and reperfusion.
European journal of pharmacology 2003;465(3):275-80.
2003: Ioanna Andreadou; Eleni A Rekka; Panos N Kourounakis
Effect of novel anti-inflammatory ethanolamine derivatives with antioxidant properties on drug metabolising enzymes.
European journal of drug metabolism and pharmacokinetics 2003;28(1):7-10.
2002: Michael C Chrysselis; Eleni A Rekka; Ioanna C Siskou; Panos N Kourounakis
Nitric oxide releasing morpholine derivatives as hypolipidemic and antioxidant agents.
Journal of medicinal chemistry 2002;45(24):5406-9.
2002: Angeliki P Kourounakis; Panayiotis Victoratos; N Peroulis; N Stefanou; Minas Yiangou; Loukia Hadjipetrou; Panos N Kourounakis
Experimental hyperlipidemia and the effect of NSAIDs.
Experimental and molecular pathology 2002;73(2):135-8.
2002: Angeliki P Kourounakis; Karyofyllis Tsiakitzis; D Paramithiotis; Katerina Kotzampassi; Panos N Kourounakis
Effect of a novel NSAID derivative with antioxidant moiety on oxidative damage caused by liver and cerebral ischaemia-reperfusion in rats.
The Journal of pharmacy and pharmacology 2002;54(8):1091-6.
2002: Angeliki P Kourounakis; Andreana N Assimopoulou; Vassilios P Papageorgiou; Antonios M Gavalas; Panos N Kourounakis
Alkannin and shikonin: effect on free radical processes and on inflammation - a preliminary pharmacochemical investigation.
Archiv der Pharmazie 2002;335(6):262-6.
2002: Ioanna Andreadou; Apostolos Papalois; John K Triantafillidis; Maria D Demonakou; Vassilios Govosdis; Maria Vidali; Emmanuel Anagnostakis; Panos N Kourounakis
Beneficial effect of a novel non-steroidal anti-inflammatory agent with basic character and antioxidant properties on experimental colitis in rats.
European journal of pharmacology 2002;441(3):209-14.
2002: Leto-A Tziveleka; Angeliki P Kourounakis; Panos N Kourounakis; Vassilios Roussis; Constantinos Vagias
Antioxidant potential of natural and synthesised polyprenylated hydroquinones.
Bioorganic & medicinal chemistry 2002;10(4):935-9.
2002: Panagiotis Marakos; Spyroula Papakonstantinou-Garoufalias; Ekaterini Tani; Panos N Kourounakis; George Athanasiou; Aikaterini Chytyroglou-Lada
Synthesis and antifungal and antioxidant properties of some new 5-substituted-4-amino(or aryl)-3-mercapto-4(H)-1,2,4-triazoles.
Arzneimittel-Forschung 2002;52(7):572-7.
2002: Bianca Topic; E Tani; Karyofyllis Tsiakitzis; Panos N Kourounakis; Ekrem Dere; Rüdiger U Hasenöhrl; R Häcker; Claudia Mattern; Joseph P Huston
Enhanced maze performance and reduced oxidative stress by combined extracts of zingiber officinale and ginkgo biloba in the aged rat.
Neurobiology of aging 2002;23(1):135-43.
2001: Maria Koufaki; Theodora Calogeropoulou; Anastasia Detsi; A Roditis; Angeliki P Kourounakis; Panagiota Papazafiri; Karyofyllis Tsiakitzis; Catherine Gaitanaki; Isidoros Beis; Panos N Kourounakis
Novel potent inhibitors of lipid peroxidation with protective effects against reperfusion arrhythmias.
Journal of medicinal chemistry 2001;44(24):4300-3.
2000: Michael C Chrysselis; Eleni A Rekka; Panos N Kourounakis
Cytochrome P450 modification by a new oxazine derivative with hypolipidemic activity.
Research communications in molecular pathology and pharmacology 2000;108(5-6):325-31.
2000: Panos N Kourounakis; Karyofyllis Tsiakitzis; Angeliki P Kourounakis; Dimitrios Galanakis
Reduction of gastrointestinal toxicity of NSAIDs via molecular modifications leading to antioxidant anti-inflammatory drugs.
Toxicology 2000;144(1-3):205-10.
2000: Michael C Chrysselis; Eleni A Rekka; Panos N Kourounakis
Hypocholesterolemic and hypolipidemic activity of some novel morpholine derivatives with antioxidant activity.
Journal of medicinal chemistry 2000;43(4):609-12.
1998: Antonios M Gavalas; Loukia Hadjipetrou; Panos N Kourounakis
Synthesis of novel derivatives of aroylaminoalcohols and 3-amino-substituted 1-phenylpropanols with potential anti-inflammatory and immunomodulating activities.
The Journal of pharmacy and pharmacology 1998;50(6):583-91.
1998: S S Papakonstantinou-Garoufalia; Ekaterini Tani; OG Todoulou; AE Papadaki-Valiraki; EC Filippatos; Erik De Clercq; Panos N Kourounakis
Synthesis and pharmacochemical investigation of some novel 1,2,4-4H-triazoles with potential antiviral activity.
The Journal of pharmacy and pharmacology 1998;50(1):117-24.
1997: Angeliki P Kourounakis; Eleni A Rekka; Panos N Kourounakis
Antioxidant activity of guaiazulene and protection against paracetamol hepatotoxicity in rats.
The Journal of pharmacy and pharmacology 1997;49(9):938-42.
1997: Ioanna Andreadou; Eleni A Rekka; Vassilis J Demopoulos; G J Bijloo; Panos N Kourounakis
Synthesis, antioxidant and anti-inflammatory activity of novel substituted ethylenediamines and ethanolamines. A preliminary quantitative structure-activity relationship study.
Arzneimittel-Forschung 1997;47(5):643-7.
1997: Angeliki P Kourounakis; Eleni A Rekka; Panos N Kourounakis
Effect of guaiazulene on some cytochrome P450 activities. Implication in the metabolic activation and hepatotoxicity of paracetamol.
Archiv der Pharmazie 1997;330(1-2):7-11.
1996: G V Rekatas; E Tani; V J Demopoulos; Panos N Kourounakis
Synthesis of GABA-valproic acid derivatives and evaluation of their anticonvulsant and antioxidant activity.
Archiv der Pharmazie 1996;329(8-9):393-8.
1996: Eleni A Rekka; Angeliki P Kourounakis; Panos N Kourounakis
Investigation of the effect of chamazulene on lipid peroxidation and free radical processes.
Research communications in molecular pathology and pharmacology 1996;92(3):361-4.
1996: A N Alexidis; J N Commandeur; E Groot; Panos N Kourounakis; Eleni A Rekka; N P Vermeulen
Novel piperidine derivatives: inhibitory properties towards cytochrome P450 isoforms, and cytoprotective and cytotoxic characteristics.
Environmental toxicology and pharmacology 1996;1(1):81-8.
1996: Eleni A Rekka; Panos N Kourounakis
An approach to QSAR of 16-substituted pregnenolones as microsomal enzyme inducers.
European journal of drug metabolism and pharmacokinetics 1996;21(1):7-11.
1995: R Mgonzo; Athina Geronikaki; Panos N Kourounakis
Synthesis and antiinflammatory activity of some new thiazole derivatives.
Die Pharmazie 1995;50(7):505-6.
1995: Panos N Kourounakis; E Tani
Effect of phenobarbital, spironolactone and pregnenolone-16 alpha-carbonitrile on rat hepatic beta-glucuronidase.
Research communications in molecular pathology and pharmacology 1995;88(1):119-22.
1995: A N Alexidis; Eleni A Rekka; V J Demopoulos; Panos N Kourounakis
Novel 1,4 substituted piperidine derivatives. Synthesis and correlation of antioxidant activity with structure and lipophilicity.
The Journal of pharmacy and pharmacology 1995;47(2):131-7.
1994: Panos N Kourounakis; Eleni A Rekka
Effect of spironolactone on dimethyl mercury toxicity. A possible molecular mechanism.
Arzneimittel-Forschung 1994;44(10):1150-3.
1994: E Tani; Eleni A Rekka; Panos N Kourounakis
Synthesis and effect on free radical processes on some substituted morpholine derivatives with potential biologic activity.
Arzneimittel-Forschung 1994;44(9):992-4.
1994: Eleni A Rekka; Panos N Kourounakis
Investigation of the molecular mechanism of the antioxidant activity of some Allium sativum ingredients.
Die Pharmazie 1994;49(7):539-40.
1994: A N Alexidis; Eleni A Rekka; Panos N Kourounakis
Influence of mercury and cadmium intoxication on hepatic microsomal CYP2E and CYP3A subfamilies.
Research communications in molecular pathology and pharmacology 1994;85(1):67-72.
1994: E Sotiropoulou; Panos N Kourounakis
Synthesis and pharmacochemistry of some new aminoketones with local anaesthetic activity.
Arzneimittel-Forschung 1994;44(6):702-6.
1994: E Sotiropoulou; Panos N Kourounakis
Pharmacochemistry of novel aminoketone phthalimide, delta 4-tetrahydrophthalimide, and arylsuccinimide derivatives with local anaesthetic activity.
Archiv der Pharmazie 1994;327(1):21-6.
1994: A Gavalas; Panayiotis Victoratos; Minas Yiangou; L Hadjipetrou-Kourounakis; Eleni A Rekka; Panos N Kourounakis
The anti-inflammatory effect of opioids.
The International journal of neuroscience 1994;74(1-4):259-64.
1993: E Sotiropoulou; Athina Geronikaki; Panos N Kourounakis
Synthesis and physicochemical study (pka, logP) of some new thiazole derivatives with probable local anaesthetic activity.
Die Pharmazie 1993;48(11):856-7.
1993: E Tani; Panos N Kourounakis
Action of oxatomide on the hepatic microsomal enzyme system. Effect of the monoxygenase and peroxidase activity of P-450 on drug N-demethylations.
Research communications in chemical pathology and pharmacology 1993;80(3):375-8.
1992: I Andreadou; Eleni A Rekka; V J Demopoulos; Panos N Kourounakis
Effect of some novel ethylenediamine and ethanolamine derivatives on carrageenan-induced inflammation. Correlation with antioxidant activity and structural characteristics.
Research communications in chemical pathology and pharmacology 1992;78(2):245-8.
1992: Panos N Kourounakis; G P Pouskoulelis; Eleni A Rekka
Interaction of spironolactone with mercury. A possible molecular mechanism.
Arzneimittel-Forschung 1992;42(8):1025-8.
1992: A Geronikakis; E Sotiropoulou; Panos N Kourounakis
Synthesis and mass spectra of some thiazole aminoketones with prospective local anaesthetic activity.
Die Pharmazie 1992;47(4):298-300.
1991: Panos N Kourounakis; Eleni A Rekka
Effect on active oxygen species of alliin and Allium sativum (garlic) powder.
Research communications in chemical pathology and pharmacology 1991;74(2):249-52.
1991: Panos N Kourounakis; Eleni A Rekka; L Hadjipetrou-Kourounakis
Restoration of impaired drug metabolism of rats with adjuvant induced disease by two steroids with different influence on drug biotransformation.
Die Pharmazie 1991;46(10):727-9.
1991: D M Spyriounis; Eleni A Rekka; V J Demopoulos; Panos N Kourounakis
Cu(II) complex of an estradiol derivative with potent anti-inflammatory properties.
Archiv der Pharmazie 1991;324(9):533-6.
1991: Eleni A Rekka; Panos N Kourounakis
Effect of hydroxyethyl rutosides and related compounds on lipid peroxidation and free radical scavenging activity. Some structural aspects.
The Journal of pharmacy and pharmacology 1991;43(7):486-91.
1991: L Kourounakis; A Gavalas; E E Karagouni; D Litina; Panos N Kourounakis
Anti-inflammatory and immunomodulating effects of the novel agent gamma-(2-aminoethylamino)-2-butyrothienone. 2nd communication: inhibitory effect on rat adjuvant induced disease.
Arzneimittel-Forschung 1991;41(5):537-41.
1991: A Gavalas; L Kourounakis; D Litina; Panos N Kourounakis
Anti-inflammatory and immunomodulating effects of the novel agent gamma-(2-aminoethylamino)-2-butyrothienone. 1st communication: inhibitory effects on mouse paw edema.
Arzneimittel-Forschung 1991;41(4):423-6.
1991: Panos N Kourounakis; Eleni A Rekka
Induction of drug metabolism can be a homeostatic response.
Archiv der Pharmazie 1991;324(3):161-4.
1991: E Tani; Eleni A Rekka; Panos N Kourounakis
Modification of lipid peroxidation by some known substituted imidazole derivatives. An attempt to correlate their antioxidant activity with lipophilicity.
Die Pharmazie 1991;46(2):118-9.
1991: Panos N Kourounakis; Eleni A Rekka; V J Demopoulos; S Retsas
Effect of the position of the cyano-group of cyanopregnenolones on their drug metabolic inducing activity.
European journal of drug metabolism and pharmacokinetics 1991;16(1):9-13.
1991: Panos N Kourounakis; Eleni A Rekka
Effect of adaptive steroids on the impairment of hepatic drug metabolic activity caused by hepatotoxic agents.
European journal of drug metabolism and pharmacokinetics 1991;Spec No 3():17-23.
1990: Eleni A Rekka; L Kourounakis; Panos N Kourounakis
Antioxidant activity of and interleukin production affected by honey bee venom.
Arzneimittel-Forschung 1990;40(8):912-3.
1990: Eleni A Rekka; S Retsas; V J Demopoulos; Panos N Kourounakis
Lipophilicity of some substituted morpholine derivatives synthesized as potential antinociceptive agents.
Archiv der Pharmazie 1990;323(1):53-6.
1989: E Tani; Eleni A Rekka; G Iconomidis; Panos N Kourounakis
Modification of drug metabolic processes by compounds which intervene with the function of cytochrome P-450 as a mono-oxygenase and as an oxidase.
Arzneimittel-Forschung 1989;39(11):1399-402.
1989: Athina Geronikaki; E Sotiropoulou; Panos N Kourounakis
Synthesis of some thiazole derivatives with prospective local anaesthetic activity.
Die Pharmazie 1989;44(5):349.
1989: L Hadjipetrou-Kourounakis; E Karagounis; Eleni A Rekka; Panos N Kourounakis
Immunosuppression by a novel analgesic-opioid agonist.
Scandinavian journal of immunology 1989;29(4):449-58.
1987: L Hadjipetrou-Kourounakis; Minas Yiangou; Panos N Kourounakis
Effect of age on the induction of in vitro drug metabolism by pregnenolone-16 alpha-carbonitrile (PCN); effect of age and PCN on immune responses.
Die Pharmazie 1987;42(10):677-80.
1987: Eleni A Rekka; C Gouma; Panos N Kourounakis
In vivo interaction of spironolactone and phenobarbital with cholesterol; effect on cholesterol organ concentration.
Die Pharmazie 1987;42(2):107-8.
1986: Panos N Kourounakis; Eleni A Rekka
Effect of benzopyrone derivatives on drug activity and metabolism.
European journal of drug metabolism and pharmacokinetics 1986;11(4):269-73.
1984: Panos N Kourounakis; L Hadjipetrou-Kourounakis
Effect of pregnenolone-16 alpha-carbonitrile and other microsomal enzyme inducers on drug metabolism and some parameters of adjuvant induced disease in rats.
Pharmaceutica acta Helvetiae 1984;59(12):348-52.
1983: L Hadjipetrou-Kourounakis; Panos N Kourounakis
Effect of 5-2',5'-dimethyl-phenyl-6-oxa-1-azabicyclo[3,3,0]octane on adjuvant induced disease.
Pharmaceutica acta Helvetiae 1983;58(9-10):256-8.