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Mihály Kovács

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Nikolett T Nagy; Takeshi Sakamoto; James R Sellers; Saikat Chakraborty; Gábor M Harami; Mihály Kovács
A subdomain interaction at the base of the lever allosterically tunes the mechanochemical mechanism of Myosin 5a.
Kata Sarlós; Máté Gyimesi; Mihály Kovács
RecQ helicase translocates along single-stranded DNA with a moderate processivity and tight mechanochemical coupling.
Máté Gyimesi; Gábor M Harami; Eszter Hazai; Zsolt Bikádi; Kata Sarlós; Mihály Kovács
Complex activities of the human Bloom's syndrome helicase are encoded in a core region comprising the RecA and Zn-binding domains.

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All Publications

2013: Nikolett T Nagy; Takeshi Sakamoto; James R Sellers; Saikat Chakraborty; Gábor M Harami; Mihály Kovács
A subdomain interaction at the base of the lever allosterically tunes the mechanochemical mechanism of Myosin 5a.
PloS one 2013;8(5):e62640.
2012: Kata Sarlós; Máté Gyimesi; Mihály Kovács
RecQ helicase translocates along single-stranded DNA with a moderate processivity and tight mechanochemical coupling.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(25):9804-9.
2012: Máté Gyimesi; Gábor M Harami; Eszter Hazai; Zsolt Bikádi; Kata Sarlós; Mihály Kovács
Complex activities of the human Bloom's syndrome helicase are encoded in a core region comprising the RecA and Zn-binding domains.
Nucleic acids research 2012;40(9):3952-63.
2012: Xuefei Ma; James R Sellers; Aibing Wang; Yingfan Zhang; Mary Anne Conti; Mihály Kovács; Robert S Adelstein
Nonmuscle myosin II exerts tension but does not translocate actin in vertebrate cytokinesis.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(12):4509-14.
2011: Balázs Takács; Elizabeth O'Neall-Hennessey; Csaba Hetényi; József Kardos; Andrew G Szent-Györgyi; Mihály Kovács
Myosin cleft closure determines the energetics of the actomyosin interaction.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011;25(1):111-21.
2010: András Málnási-Csizmadia; Mihály Kovács
Emerging complex pathways of the actomyosin powerstroke.
Trends in biochemical sciences 2010;35(12):684-90.
2010: Máté Gyimesi; Kata Sarlós; Mihály Kovács
Processive translocation mechanism of the human Bloom's syndrome helicase along single-stranded DNA.
Nucleic acids research 2010;38(13):4404-14.
2010: Balázs Takács; Neil Billington; Máté Gyimesi; Bálint Kintses; András Málnási-Csizmadia; Peter J Knight; Mihály Kovács
Myosin complexed with ADP and blebbistatin reversibly adopts a conformation resembling the start point of the working stroke.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(15):6799-804.
2010: Máté Gyimesi; Kata Sarlós; Imre Derényi; Mihály Kovács
Streamlined determination of processive run length and mechanochemical coupling of nucleic acid motor activities.
Nucleic acids research 2010;38(7):e102.
2008: Yasuharu Takagi; Yi Yang; Ikuko Fujiwara; Damon Jacobs; Richard E Cheney; James R Sellers; Mihály Kovács
Human myosin Vc is a low duty ratio, nonprocessive molecular motor.
The Journal of biological chemistry 2008;283(13):8527-37.
2007: Judit Tóth; Balázs Varga; Mihály Kovács; András Málnási-Csizmadia; Beáta G Vértessy
Kinetic mechanism of human dUTPase, an essential nucleotide pyrophosphatase enzyme.
The Journal of biological chemistry 2007;282(46):33572-82.
2007: András Málnási-Csizmadia; Judit Tóth; David S Pearson; Csaba Hetényi; László Nyitray; Michael A Geeves; Clive R Bagshaw; Mihály Kovács
Selective perturbation of the myosin recovery stroke by point mutations at the base of the lever arm affects ATP hydrolysis and phosphate release.
The Journal of biological chemistry 2007;282(24):17658-64.
2007: Mihály Kovács; Kavitha Thirumurugan; Peter J Knight; James R Sellers
Load-dependent mechanism of nonmuscle myosin 2.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(24):9994-9.
2007: Yuting Yang; S Gourinath; Mihály Kovács; László Nyitray; Robbie Reutzel; Daniel M Himmel; Elizabeth O'Neall-Hennessey; Ludmilla Reshetnikova; Andrew G Szent-Györgyi; Jerry H Brown; Carolyn Cohen
Rigor-like structures from muscle myosins reveal key mechanical elements in the transduction pathways of this allosteric motor.
Structure (London, England : 1993) 2007;15(5):553-64.
2006: Balint Kintses; Zoltán Simon; Máté Gyimesi; Judit Tóth; Balázs Jelinek; Csaba Niedetzky; Mihály Kovács; András Málnási-Csizmadia
Enzyme kinetics above denaturation temperature: a temperature-jump/stopped-flow apparatus.
Biophysical journal 2006;91(12):4605-10.
2006: Yi Yang; Mihály Kovács; Takeshi Sakamoto; Fang Zhang; Daniel P Kiehart; James R Sellers
Dimerized Drosophila myosin VIIa: a processive motor.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(15):5746-51.
2005: Yi Yang; Mihály Kovács; Qian Xu; John B Anderson; James R Sellers
Myosin VIIB from Drosophila is a high duty ratio motor.
The Journal of biological chemistry 2005;280(37):32061-8.
2005: Judit Tóth; Mihály Kovács; Fei Wang; László Nyitray; James R Sellers
Myosin V from Drosophila reveals diversity of motor mechanisms within the myosin V family.
The Journal of biological chemistry 2005;280(34):30594-603.
2005: Xiong Liu; Shi Shu; Mihály Kovács; Edward D Korn
Biological, biochemical, and kinetic effects of mutations of the cardiomyopathy loop of Dictyostelium myosin II: importance of ALA400.
The Journal of biological chemistry 2005;280(29):26974-83.
2005: Kye-Young Kim; Mihály Kovács; Sachiyo Kawamoto; James R Sellers; Robert S Adelstein
Disease-associated mutations and alternative splicing alter the enzymatic and motile activity of nonmuscle myosins II-B and II-C.
The Journal of biological chemistry 2005;280(24):22769-75.
2005: Mihály Kovács; Fei Wang; James R Sellers
Mechanism of action of myosin X, a membrane-associated molecular motor.
The Journal of biological chemistry 2005;280(15):15071-83.
2004: Mihály Kovács; Judit Tóth; Csaba Hetényi; András Málnási-Csizmadia; James R Sellers
Mechanism of blebbistatin inhibition of myosin II.
The Journal of biological chemistry 2004;279(34):35557-63.
2004: Mihály Kovács; Judit Tóth; László Nyitray; James R Sellers
Two-headed binding of the unphosphorylated nonmuscle heavy meromyosin.ADP complex to actin.
Biochemistry 2004;43(14):4219-26.
2004: Mihály Kovács; Judit Tóth; András Málnási-Csizmadia; Clive R Bagshaw; László Nyitray
Engineering lysine reactivity as a conformational sensor in the Dictyostelium myosin II motor domain.
Journal of muscle research and cell motility 2004;25(1):95-102.
2003: Mihály Kovács; Fei Wang; Aihua Hu; Yue Zhang; James R Sellers
Functional divergence of human cytoplasmic myosin II: kinetic characterization of the non-muscle IIA isoform.
The Journal of biological chemistry 2003;278(40):38132-40.
2003: Paul B Conibear; Clive R Bagshaw; Piotr G Fajer; Mihály Kovács; András Málnási-Csizmadia
Myosin cleft movement and its coupling to actomyosin dissociation.
Nature structural biology 2003;10(10):831-5.
2002: Stuart Wakelin; Paul B Conibear; Robert J Woolley; David N Floyd; Clive R Bagshaw; Mihály Kovács; András Málnási-Csizmadia
Engineering Dictyostelium discoideum myosin II for the introduction of site-specific fluorescence probes.
Journal of muscle research and cell motility 2002;23(7-8):673-83.
2001: András Málnási-Csizmadia; David S Pearson; Mihály Kovács; Robert J Woolley; Michael A Geeves; Clive R Bagshaw
Kinetic resolution of a conformational transition and the ATP hydrolysis step using relaxation methods with a Dictyostelium myosin II mutant containing a single tryptophan residue.
Biochemistry 2001;40(42):12727-37.