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Petri Kovanen

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Andrea Dichlberger; Petri T Kovanen; Wolfgang J Schneider
Mast cells: from lipid droplets to lipid mediators.
Kristiina Rajamäki; Karl E O Akerman; Petri T Kovanen; Tommy Nordström; Katariina Nurmi; Katariina Öörni; Kari K Eklund
Extracellular Acidosis Is a Novel Danger Signal Alerting Innate Immunity via the NLRP3 Inflammasome.
K A Elisa Kallio; Petri T Kovanen; Kati Hyvärinen; Matti Jauhiainen; Pirkko J Pussinen
Very low density lipoproteins derived from periodontitis patients facilitate macrophage activation via lipopolysaccharide function.

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All Publications

2013: Andrea Dichlberger; Petri T Kovanen; Wolfgang J Schneider
Mast cells: from lipid droplets to lipid mediators.
Clinical science (London, England : 1979) 2013;125(3):121-30.
2013: Kristiina Rajamäki; Karl E O Akerman; Petri T Kovanen; Tommy Nordström; Katariina Nurmi; Katariina Öörni; Kari K Eklund
Extracellular Acidosis Is a Novel Danger Signal Alerting Innate Immunity via the NLRP3 Inflammasome.
The Journal of biological chemistry 2013;288(19):13410-9.
2013: K A Elisa Kallio; Petri T Kovanen; Kati Hyvärinen; Matti Jauhiainen; Pirkko J Pussinen
Very low density lipoproteins derived from periodontitis patients facilitate macrophage activation via lipopolysaccharide function.
Metabolism: clinical and experimental 2013;62(5):661-8.
2013: Robert M Badeau; Petri T Kovanen; Miriam Lee-Rueckert; Jari Metso; Matti J Tikkanen; Matti Jauhiainen
The impact of gender and serum estradiol levels on HDL-mediated reverse cholesterol transport.
European journal of clinical investigation 2013;43(4):317-23.
2013: Alpo Vuorio; Jaana Kuoppala; Kieran F Docherty; Steve E Humphries; Petri T Kovanen
Statin treatment of children with familial hypercholesterolemia--trying to balance incomplete evidence of long-term safety and clinical accountability: are we approaching a consensus?
Atherosclerosis 2013;226(2):315-20.
2013: Olli T Raitakari; Veikko Salomaa; Markku J Savolainen; Tiina Solakivi; Jouko Sundvall; Jorma S A Viikari; Salim Yusuf; Sonia S Anand; Minna L Hannuksela; Jussi Hernesniemi; Matti Jauhiainen; Antti Jula; Markus Juonala; Mika Kähönen; Y Antero Kesäniemi; Petri T Kovanen; Terho Lehtimäki; Jaana Leiviskä; Britt-Marie Loo; Ville-Petteri Mäkinen; Jukka Marniemi; Matthew J McQueen; Ruby Miller; Jaakko Niemi; Markku Peltonen; Mika Ala-Korpela
Computationally estimated apolipoproteins B and A1 in predicting cardiovascular risk.
Atherosclerosis 2013;226(1):245-51.
2012: Reija Silvennoinen; Annabel F Valledor; Liqing Yu; Gemma Llaverias; Jari Metso; Noemi Rotllan; Francisco Blanco-Vaca; Joan Carles Escola-Gil; Jianming He; Matti Jauhiainen; Josep Julve; Petri T Kovanen; Miriam Lee-Rueckert
Acute psychological stress accelerates reverse cholesterol transport via corticosterone-dependent inhibition of intestinal cholesterol absorption.
Circulation research 2012;111(11):1459-69.
2012: Su Duy Nguyen; Tero Pihlajamaa; Katariina Öörni; Matti Jauhiainen; Miriam Lee-Rueckert; Jari Metso; Petri T Kovanen
Spontaneous remodeling of HDL particles at acidic pH enhances their capacity to induce cholesterol efflux from human macrophage foam cells.
Journal of lipid research 2012;53(10):2115-25.
2012: Mia Sneck; Gebrenegus Yohannes; Tero Pihlajamaa; Marja-Liisa Riekkola; Petri T Kovanen; Ross Milne; Su Duy Nguyen; Katariina Öörni
Conformational changes of apoB-100 in SMase-modified LDL mediate formation of large aggregates at acidic pH.
Journal of lipid research 2012;53(9):1832-9.
2012: Katriina Lipponen; Yi Liu; Patricia Wanda Stege; Katariina Öörni; Petri T Kovanen; Marja-Liisa Riekkola
Capillary electrochromatography and quartz crystal microbalance, valuable techniques in the study of heparin-lipoprotein interactions.
Analytical biochemistry 2012;424(1):71-8.
2012: Suvi Syväranta; Satu Helske; Markku Kupari; Jani Lappalainen; Petri T Kovanen
Lymphangiogenesis in aortic valve stenosis--novel regulatory roles for valvular myofibroblasts and mast cells.
Atherosclerosis 2012;221(2):366-74.
2012: Kari K Eklund; K Niemi; Petri T Kovanen
Immune functions of serum amyloid A.
Critical reviews in immunology 2012;32(4):335-48.
2012: Artturi Koivuniemi; Petri T Kovanen; Ilpo Vattulainen; Timo Vuorela; Marja T Hyvönen
Lipid exchange mechanism of the cholesteryl ester transfer protein clarified by atomistic and coarse-grained simulations.
PLoS computational biology 2012;8(1):e1002299.
2012: inka liesmaa; Jorma O Kokkonen; Petri T Kovanen; Naotaka Shiota; Ken A Lindstedt
Bradykinin type-2 receptor expression correlates with age and is subjected to transcriptional regulation.
International journal of vascular medicine 2012;2012():159646.
2011: Andrea Dichlberger; Katarina Hattula; Reijo Kakela; Jani Lappalainen; Stefanie Schlager; Wolfgang J Schneider; Sarah J Butcher; Petri T Kovanen
Lipid body formation during maturation of human mast cells.
Journal of lipid research 2011;52(12):2198-208.
2011: Jaakko I Lommi; Matti Jauhiainen; Petri T Kovanen; Markku Kupari; Miriam Lee-Rueckert; Satu Helske
High-density lipoproteins (HDL) are present in stenotic aortic valves and may interfere with the mechanisms of valvular calcification.
Atherosclerosis 2011;219(2):538-44.
2011: Timo E Strandberg; Petri T Kovanen; Kari K Eklund
Is the "lipid paradox" in rheumatoid arthritis really a paradox? Comment on the article by Bartels et al.
Arthritis and rheumatism 2011;63(11):3644-5; author's reply 3645-6.
2011: Miriam Lee-Rueckert; Petri T Kovanen
Extracellular modifications of HDL in vivo and the emerging concept of proteolytic inactivation of preβ-HDL.
Current opinion in lipidology 2011;22(5):394-402.
2011: Jani Saksi; Oili Salonen; Lauri Soinne; Riitta Sonninen; Jarno Tuimala; Petra Ijäs; Markku Kaste; Petri T Kovanen; Erno M Lehtonen-Smeds; Krista Nuotio; eija saimanen; Perttu J Lindsberg
Gene expression differences between stroke-associated and asymptomatic carotid plaques.
Journal of molecular medicine (Berlin, Germany) 2011;89(10):1015-26.
2011: Jing Wang; Jian-An Wang; Mei-Xiang Xiang; Lunyin Yu; Sara Sjöberg; Galina K Sukhova; Xinghui Sun; Ting-Ting Tang; Xin Tu; Mervi Alanne; Han Chen; Xiang Cheng; Daniel H Conrad; Aina He; Toshiaki Kawakami; Petri T Kovanen; Yu-Hua Liao; Peter Libby; Yan Lin; Guo-Ping Shi
IgE stimulates human and mouse arterial cell apoptosis and cytokine expression and promotes atherogenesis in Apoe-/- mice.
The Journal of clinical investigation 2011;121(9):3564-77.
2011: Anita M Tuomainen; Pekka Saikku; Pauliina I Ehlers; Kati Hyvärinen; Matti Jauhiainen; Petri T Kovanen; Maija Leinonen; Eero Mervaala; Pirkko J Pussinen
The effect of proatherogenic microbes on macrophage cholesterol homeostasis in apoE-deficient mice.
Microbial pathogenesis 2011;51(3):217-24.
2011: Riia Plihtari; Petri T Kovanen; Katariina Öörni
Acidity increases the uptake of native LDL by human monocyte-derived macrophages.
Atherosclerosis 2011;217(2):401-6.
2011: M John Chapman; Olivier S Descamps; Edward Fisher; Henry N Ginsberg; Petri T Kovanen; Jan Albert Kuivenhoven; Philippe Lesnik; Luis Masana; Børge G Nordestgaard; Kausik K Ray; Zeljko Reiner; Marja-Riitta Taskinen; Lale Tokgözoglu; Anne Tybjaerg-Hansen; Gerald F Watts; Pierre Amarenco; Felicita Andreotti; Jan Borén; Alberico L Catapano
Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for management.
European heart journal 2011;32(11):1345-61.
2011: Katri Niemi; Laura Teirilä; Jani Lappalainen; Kristiina Rajamäki; Marc H Baumann; Henrik Wolff; Petri T Kovanen; Sampsa Matikainen; Katariina Öörni; Kari K Eklund
Serum amyloid A activates the NLRP3 inflammasome via P2X7 receptor and a cathepsin B-sensitive pathway.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(11):6119-28.
2011: Jesper Swedenborg; Mikko I Mäyränpää; Petri T Kovanen
Mast cells: important players in the orchestrated pathogenesis of abdominal aortic aneurysms.
Arteriosclerosis, thrombosis, and vascular biology 2011;31(4):734-40.
2011: Alpo F Vuorio; Petri T Kovanen
Do statins reduce the incidence of stroke in familial hypercholesterolemia?
Expert review of cardiovascular therapy 2011;9(3):349-53.
2011: Miriam Lee-Rueckert; Reija Silvennoinen; Noemi Rotllan; Ilona Judström; Francisco Blanco-Vaca; Jari Metso; Matti Jauhiainen; Petri T Kovanen; Joan Carles Escola-Gil
Mast cell activation in vivo impairs the macrophage reverse cholesterol transport pathway in the mouse.
Arteriosclerosis, thrombosis, and vascular biology 2011;31(3):520-7.
2011: Anna Oksaharju; Matti Kankainen; Riina A Kekkonen; Ken A Lindstedt; Petri T Kovanen; Riitta Korpela; Minja Miettinen
Probiotic Lactobacillus rhamnosus downregulates FCER1 and HRH4 expression in human mast cells.
World journal of gastroenterology : WJG 2011;17(6):750-9.
2011: Jani Lappalainen; Ken A Lindstedt; Riina Oksjoki; Petri T Kovanen
OxLDL-IgG immune complexes induce expression and secretion of proatherogenic cytokines by cultured human mast cells.
Atherosclerosis 2011;214(2):357-63.
2011: Cristina Bancells; Sonia Benítez; Jordi Ordóñez-Llanos; Katariina Öörni; Petri T Kovanen; Ross W Milne; José Luis Sánchez-Quesada
Immunochemical analysis of the electronegative LDL subfraction shows that abnormal N-terminal apolipoprotein B conformation is involved in increased binding to proteoglycans.
The Journal of biological chemistry 2011;286(2):1125-33.
2011: Vibhor Kumar; Sarah J Butcher; Peter Engelhardt; Jukka Heikkonen; Kimmo Kaski; Mika Ala-Korpela; Katariina Öörni; Petri T Kovanen
Three-dimensional cryoEM reconstruction of native LDL particles to 16Å resolution at physiological body temperature.
PloS one 2011;6(5):e18841.
2010: Børge G Nordestgaard; M John Chapman; Kausik Ray; Jan Borén; Felicita Andreotti; Gerald F Watts; Henry Ginsberg; Pierre Amarenco; Alberico Catapano; Olivier S Descamps; Edward Fisher; Petri T Kovanen; Jan Albert Kuivenhoven; Philippe Lesnik; Luis Masana; Zeljko Reiner; Marja-Riitta Taskinen; Lale Tokgözoglu; Anne Tybjaerg-Hansen
Lipoprotein(a) as a cardiovascular risk factor: current status.
European heart journal 2010;31(23):2844-53.
2010: Satu Helske; Petri T Kovanen; Jyri Lommi; Heikki Turto; Markku Kupari
Transcardiac gradients of circulating apelin: extraction by normal hearts vs. release by hearts failing due to pressure overload.
Journal of applied physiology (Bethesda, Md. : 1985) 2010;109(6):1744-8.
2010: Miriam Lee-Rueckert; Jani Lappalainen; Hannele Leinonen; Tero Pihlajamaa; Matti Jauhiainen; Petri T Kovanen
Acidic extracellular environments strongly impair ABCA1-mediated cholesterol efflux from human macrophage foam cells.
Arteriosclerosis, thrombosis, and vascular biology 2010;30(9):1766-72.
2010: Joanna Witos; Geraldine Cilpa; Gebrenegus Yohannes; Katariina Öörni; Petri T Kovanen; Matti Jauhiainen; Marja-Liisa Riekkola
Sugar treatment of human lipoprotein particles and their separation by capillary electrophoresis.
Journal of separation science 2010;33(16):2528-35.
2010: Riia Plihtari; Eva Hurt-Camejo; Katariina Öörni; Petri T Kovanen
Proteolysis sensitizes LDL particles to phospholipolysis by secretory phospholipase A2 group V and secretory sphingomyelinase.
Journal of lipid research 2010;51(7):1801-9.
2010: Suvi Syväranta; Satu Helske; Mika Laine; Jani Lappalainen; Markku Kupari; Mikko I Mäyränpää; Ken A Lindstedt; Petri T Kovanen
Vascular endothelial growth factor-secreting mast cells and myofibroblasts: a novel self-perpetuating angiogenic pathway in aortic valve stenosis.
Arteriosclerosis, thrombosis, and vascular biology 2010;30(6):1220-7.
2010: Katariina Lähdesmäki; O H Samuli Ollila; Artturi Koivuniemi; Petri T Kovanen; Marja T Hyvönen
Membrane simulations mimicking acidic pH reveal increased thickness and negative curvature in a bilayer consisting of lysophosphatidylcholines and free fatty acids.
Biochimica et biophysica acta 2010;1798(5):938-46.
2010: Lucia D'Ulivo; Joanna Witos; Katariina Öörni; Petri T Kovanen; Marja-Liisa Riekkola
Open tubular capillary electrochromatography: a useful microreactor for collagen I glycation and interaction studies with low-density lipoprotein particles.
Analytica chimica acta 2010;664(2):185-9.
2010: Ai-Jun Wang; Kati Vainikka; Joanna Witos; Lucia D'Ulivo; Geraldine Cilpa; Petri T Kovanen; Katariina Öörni; Matti Jauhiainen; Marja-Liisa Riekkola
Partial filling affinity capillary electrophoresis with cationic poly(vinylpyrrolidone)-based copolymer coatings for studies on human lipoprotein-steroid interactions.
Analytical biochemistry 2010;399(1):93-101.
2010: Tomas Blom; Nils Bäck; Aino-Liisa Mutka; Robert Bittman; Zaiguo Li; Angel de Lera; Petri T Kovanen; Ulf Diczfalusy; Elina Ikonen
FTY720 stimulates 27-hydroxycholesterol production and confers atheroprotective effects in human primary macrophages.
Circulation research 2010;106(4):720-9.
2010: Raine Toivonen; Mikko I Mäyränpää; Petri T Kovanen; Mikko Savontaus
Dilated cardiomyopathy alters the expression patterns of CAR and other adenoviral receptors in human heart.
Histochemistry and cell biology 2010;133(3):349-57.
2010: Osmo Kari; Tari Haahtela; Petri Laine; Juha P Turunen; Marjatta Kari; Seppo Sarna; Tarja Laitinen; Petri T Kovanen
Cellular characteristics of non-allergic eosinophilic conjunctivitis.
Acta ophthalmologica 2010;88(2):245-50.
2010: Hanna M Heikkilä; Julia Trosien; Jari Metso; Matti Jauhiainen; Markku O Pentikäinen; Petri T Kovanen; Ken A Lindstedt
Mast cells promote atherosclerosis by inducing both an atherogenic lipid profile and vascular inflammation.
Journal of cellular biochemistry 2010;109(3):615-23.
2010: Pia M Isoviita; Krista Nuotio; Jani Saksi; Riitta Turunen; Petra Ijäs; Janne Pitkäniemi; Lauri Soinne; Markku Kaste; Petri T Kovanen; Perttu J Lindsberg
An imbalance between CD36 and ABCA1 protein expression favors lipid accumulation in stroke-prone ulcerated carotid plaques.
Stroke; a journal of cerebral circulation 2010;41(2):389-93.
2010: Kristiina Rajamäki; Jani Lappalainen; Katariina Öörni; Elina Välimäki; Sampsa Matikainen; Petri T Kovanen; Kari K Eklund
Cholesterol crystals activate the NLRP3 inflammasome in human macrophages: a novel link between cholesterol metabolism and inflammation.
PloS one 2010;5(7):e11765.
2010: Alpo Vuorio; Jaana Kuoppala; Petri T Kovanen; Steve E Humphries; Timo Strandberg; Serena Tonstad; Helena Gylling
Statins for children with familial hypercholesterolemia.
Cochrane database of systematic reviews (Online) 2010;(7):CD006401.
2010: Risto Lehtinen; Tiina Jauhiainen; Esko Kankuri; Ken A Lindstedt; Petri T Kovanen; Outi Kerojoki; Riitta Korpela; Heikki Vapaatalo
Effects of milk casein-derived tripeptides Ile-Pro-Pro, Val-Pro-Pro, and Leu-Pro-Pro on enzymes processing vasoactive precursors in vitro.
Arzneimittel-Forschung 2010;60(4):182-5.
2010: Ilona Judström; Heli Jukkola; Jari Metso; Matti Jauhiainen; Petri T Kovanen; Miriam Lee-Rueckert
Mast cell-dependent proteolytic modification of HDL particles during anaphylactic shock in the mouse reduces their ability to induce cholesterol efflux from macrophage foam cells ex vivo.
Atherosclerosis 2010;208(1):148-54.
2009: Katariina Lähdesmäki; Riia Plihtari; Pasi Soininen; Eva Hurt-Camejo; Mika Ala-Korpela; Katariina Öörni; Petri T Kovanen
Phospholipase A(2)-modified LDL particles retain the generated hydrolytic products and are more atherogenic at acidic pH.
Atherosclerosis 2009;207(2):352-9.
2009: Lucia D'Ulivo; Joanna Witos; Katariina Öörni; Petri T Kovanen; Marja-Liisa Riekkola
CEC: a tool for mimicking collagen-surface interactions with apolipoprotein B-100 peptides.
Electrophoresis 2009;30(22):3838-45.
2009: inka liesmaa; Hanna Leskinen; Jorma O Kokkonen; Heikki Ruskoaho; Petri T Kovanen; Ken A Lindstedt
Hypoxia-induced expression of bradykinin type-2 receptors in endothelial cells triggers NO production, cell migration, and angiogenesis.
Journal of cellular physiology 2009;221(2):359-66.
2009: Jan Nilsson; Petri T Kovanen
Shifting to new targets in pharmacological prevention of cardiovascular diseases.
Current opinion in lipidology 2009;20(5):361-2.
2009: Katariina Öörni; Petri T Kovanen
Lipoprotein modification by secretory phospholipase A(2) enzymes contributes to the initiation and progression of atherosclerosis.
Current opinion in lipidology 2009;20(5):421-7.
2009: Lars Muhl; Sebastian P Galuska; Katariina Öörni; Laura Hernández-Ruiz; Luminita-Cornelia Andrei-Selmer; Rudolf Geyer; Klaus T Preissner; Felix A Ruiz; Petri T Kovanen; Sandip M Kanse
High negative charge-to-size ratio in polyphosphates and heparin regulates factor VII-activating protease.
The FEBS journal 2009;276(17):4828-39.
2009: Kati Hyvärinen; Anita M Tuomainen; Saara Laitinen; Igor L Bykov; Liisa Törmäkangas; Kai Lindros; Reijo Kakela; Georg Alfthan; Irma Salminen; Matti Jauhiainen; Petri T Kovanen; Maija Leinonen; Pekka Saikku; Pirkko J Pussinen
Chlamydial and periodontal pathogens induce hepatic inflammation and fatty acid imbalance in apolipoprotein E-deficient mice.
Infection and immunity 2009;77(8):3442-9.
2009: Satu Mustjoki; M Ekblom; T Petteri Arstila; I Dybedal; P K Epling-Burnette; françois guilhot; Henrik Hjorth-Hansen; M Höglund; Petri T Kovanen; T Laurinolli; J Liesveld; R Paquette; J Pinilla-Ibarz; A Rauhala; N Shah; B Simonsson; M Sinisalo; J L Steegmann; L Stenke; Kimmo Porkka
Clonal expansion of T/NK-cells during tyrosine kinase inhibitor dasatinib therapy.
Leukemia 2009;23(8):1398-405.
2009: Matts D Linder; Mikko I Mäyränpää; Johan Peränen; Taija E Pietilä; Vilja M Pietiäinen; Riikka-Liisa Uronen; Vesa M Olkkonen; Petri T Kovanen; Elina Ikonen
Rab8 regulates ABCA1 cell surface expression and facilitates cholesterol efflux in primary human macrophages.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(6):883-8.
2009: Artturi Koivuniemi; Mikko Heikelä; Petri T Kovanen; Ilpo Vattulainen; Marja T Hyvönen
Atomistic simulations of phosphatidylcholines and cholesteryl esters in high-density lipoprotein-sized lipid droplet and trilayer: clues to cholesteryl ester transport and storage.
Biophysical journal 2009;96(10):4099-108.
2009: Petri T Kovanen
Mast cells in atherogenesis: actions and reactions.
Current atherosclerosis reports 2009;11(3):214-9.
2009: Laura Calabresi; Elda Favari; Elsa Moleri; Maria Pia Adorni; Matteo Pedrelli; Sara Costa; Wendy Jessup; Ingrid C Gelissen; Petri T Kovanen; Franco Bernini; Guido Franceschini
Functional LCAT is not required for macrophage cholesterol efflux to human serum.
Atherosclerosis 2009;204(1):141-6.
2009: Cristina Bancells; Sonia Benítez; Matti Jauhiainen; Jordi Ordóñez-Llanos; Petri T Kovanen; Sandra Villegas; José Luis Sánchez-Quesada; Katariina Öörni
High binding affinity of electronegative LDL to human aortic proteoglycans depends on its aggregation level.
Journal of lipid research 2009;50(3):446-55.
2009: Shuhei Nakanishi; Riikka Vikstedt; Sanni Söderlund; Miriam Lee-Rueckert; Anne Hiukka; Christian Ehnholm; Mikko Muilu; Jari Metso; Jussi Naukkarinen; Leena Palotie; Petri T Kovanen; Matti Jauhiainen; Marja-Riitta Taskinen
Serum, but not monocyte macrophage foam cells derived from low HDL-C subjects, displays reduced cholesterol efflux capacity.
Journal of lipid research 2009;50(2):183-92.
2009: Kristiina Kanerva; Jani Lappalainen; Laura T Mäkitie; Susanna Virolainen; Petri T Kovanen; Leif C Andersson
Expression of antizyme inhibitor 2 in mast cells and role of polyamines as selective regulators of serotonin secretion.
PloS one 2009;4(8):e6858.
2009: Jørgen Valeur; Jani Lappalainen; Hannu Rita; Aung Htun Lin; Petri T Kovanen; Arnold Berstad; Kari K Eklund; Kirsi Vaali
Food allergy alters jejunal circular muscle contractility and induces local inflammatory cytokine expression in a mouse model.
BMC gastroenterology 2009;9():33.
2009: Daniel Strbian; Petri T Kovanen; Marja-Liisa Karjalainen-Lindsberg; Turgut Tatlisumak; Perttu J Lindsberg
An emerging role of mast cells in cerebral ischemia and hemorrhage.
Annals of medicine 2009;41(6):438-50.
2009: Jaakko Niemi; Ville-Petteri Mäkinen; Jukka Heikkonen; Leena Tenkanen; Yrjö Hiltunen; Minna L Hannuksela; Matti Jauhiainen; Carol Forsblom; Marja-Riitta Taskinen; Y Antero Kesäniemi; Markku Savolainen; Kimmo Kaski; Per-Henrik Groop; Petri T Kovanen; Mika Ala-Korpela
Estimation of VLDL, IDL, LDL, HDL2, apoA-I, and apoB from the Friedewald inputs--apoB and IDL, but not LDL, are associated with mortality in type 1 diabetes.
Annals of medicine 2009;41(6):451-61.
2009: Mikko A Simolin; Tanja X Pedersen; Susanne Bro; Mikko I Mäyränpää; Satu Helske; Lars B Nielsen; Petri T Kovanen
ACE inhibition attenuates uremia-induced aortic valve thickening in a novel mouse model.
BMC cardiovascular disorders 2009;9():10.
2009: Anna Oksaharju; Jani Lappalainen; Anita M Tuomainen; Pirkko J Pussinen; Mirja Puolakkainen; Petri T Kovanen; Ken A Lindstedt
Pro-atherogenic lung and oral pathogens induce an inflammatory response in human and mouse mast cells.
Journal of cellular and molecular medicine 2009;13(1):103-13.
2008: Lucia D'Ulivo; Jie Chen; Kristoffer Meinander; Katariina Öörni; Petri T Kovanen; Marja-Liisa Riekkola
In situ delipidation of low-density lipoproteins in capillary electrochromatography yields apolipoprotein B-100-coated surfaces for interaction studies.
Analytical biochemistry 2008;383(1):38-43.
2008: Artturi Koivuniemi; Petri T Kovanen; Marja T Hyvönen
Molecular dynamics simulations of a lipovitellin-derived amphiphilic beta-sheet homologous to apoB-100 beta-sheets at a hydrophobic decane-water interface.
Biochimica et biophysica acta 2008;1784(11):1668-75.
2008: Kari K Eklund; Ken Lindstedt; Charlotta Sandler; Petri T Kovanen; Leena Laasonen; Annika Juurikivi; Henrik Wolff; Marko Mykkänen; Heikki Joensuu
Maintained efficacy of the tyrosine kinase inhibitor imatinib mesylate in a patient with rheumatoid arthritis.
Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases 2008;14(5):294-6.
2008: Satu Helske; Tatu Miettinen; Helena Gylling; Mikko Mäyränpää; Jyri Lommi; Heikki Turto; Kalervo Werkkala; Markku Kupari; Petri T Kovanen
Accumulation of cholesterol precursors and plant sterols in human stenotic aortic valves.
Journal of lipid research 2008;49(7):1511-8.
2008: Markku Lehto; Mikko I Mäyränpää; Teijo Pellinen; Pekka Ihalmo; Sanna Lehtonen; Petri T Kovanen; Per-Henrik Groop; Johanna Ivaska; Vesa M Olkkonen
The R-Ras interaction partner ORP3 regulates cell adhesion.
Journal of cell science 2008;121(Pt 5):695-705.
2008: Hanna M Heikkilä; Soili Lätti; Markus J Leskinen; Jukka K Hakala; Petri T Kovanen; Ken A Lindstedt
Activated mast cells induce endothelial cell apoptosis by a combined action of chymase and tumor necrosis factor-alpha.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(2):309-14.
2008: Miriam Lee-Rueckert; Riikka Vikstedt; Jari Metso; Matti Jauhiainen; Petri T Kovanen
Association of cholesteryl ester transfer protein with HDL particles reduces its proteolytic inactivation by mast cell chymase.
Journal of lipid research 2008;49(2):358-68.
2008: Anita M Tuomainen; Matti Jauhiainen; Petri T Kovanen; Jari Metso; Susanna Paju; Pirkko J Pussinen
Aggregatibacter actinomycetemcomitans induces MMP-9 expression and proatherogenic lipoprotein profile in apoE-deficient mice.
Microbial pathogenesis 2008;44(2):111-7.
2008: Daoguang Yan; Mikko I Mäyränpää; Jenny Wong; Julia Perttilä; Markku Lehto; Matti Jauhiainen; Petri T Kovanen; Christian Ehnholm; Andrew J Brown; Vesa M Olkkonen
OSBP-related protein 8 (ORP8) suppresses ABCA1 expression and cholesterol efflux from macrophages.
The Journal of biological chemistry 2008;283(1):332-40.
2008: Dragana Vukasovic; Francesca Levi-Schaffer; Petri T Kovanen
Inflammatory angiogenesis in atherogenesis--a double-edged sword.
Annals of medicine 2008;40(8):606-21.
2008: Miriam Lee-Rueckert; Arnold von Eckardstein; Petri T Kovanen
The neutral protease chymase degrades apolipoprotein E from high-density lipoproteins.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2008;46(3):421-3.
2008: Satu Helske; Riina Oksjoki; Ken A Lindstedt; Jyri Lommi; Heikki Turto; Kalervo Werkkala; Markku Kupari; Petri T Kovanen
Complement system is activated in stenotic aortic valves.
Atherosclerosis 2008;196(1):190-200.
2007: Markus J Leskinen; Kari K Eklund; Timo Sorsa; Lorne M Golub; Petri T Kovanen; Ken A Lindstedt
Inhibition of smooth muscle cell proliferation by a chemically modified tetracycline.
Coronary artery disease 2007;18(8):663-7.
2007: inka liesmaa; Jorma O Kokkonen; Petri T Kovanen; Ken A Lindstedt
Lovastatin induces the expression of bradykinin type 2 receptors in cultured human coronary artery endothelial cells.
Journal of molecular and cellular cardiology 2007;43(5):593-600.
2007: Riina Oksjoki; Petri Laine; Satu Helske; Pirjo Vehmaan-Kreula; Mikko I Mäyränpää; Philippe Gasque; Petri T Kovanen; Markku O Pentikäinen
Receptors for the anaphylatoxins C3a and C5a are expressed in human atherosclerotic coronary plaques.
Atherosclerosis 2007;195(1):90-9.
2007: Lucia D'Ulivo; Gebrenegus Yohannes; Katariina Öörni; Petri T Kovanen; Marja-Liisa Riekkola
Open tubular capillary electrochromatography: a new technique for in situ enzymatic modification of low density lipoprotein particles and their protein-free derivatives.
The Analyst 2007;132(10):989-96.
2007: Satu Helske; Markku Kupari; Ken A Lindstedt; Petri T Kovanen
Aortic valve stenosis: an active atheroinflammatory process.
Current opinion in lipidology 2007;18(5):483-91.
2007: Jani Lappalainen; Ken A Lindstedt; Petri T Kovanen
A protocol for generating high numbers of mature and functional human mast cells from peripheral blood.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2007;37(9):1404-14.
2007: Pasi Soininen; Katariina Öörni; Hannu Maaheimo; Reino Laatikainen; Petri T Kovanen; Kimmo Kaski; Mika Ala-Korpela
1H NMR at 800 MHz facilitates detailed phospholipid follow-up during atherogenic modifications in low density lipoproteins.
Biochemical and biophysical research communications 2007;360(1):290-4.
2007: Satu Helske; Mika Laine; Markku Kupari; Jyri Lommi; Heikki Turto; Laura Nurmi; Ilkka Tikkanen; Kalervo Werkkala; Ken A Lindstedt; Petri T Kovanen
Increased expression of profibrotic neutral endopeptidase and bradykinin type 1 receptors in stenotic aortic valves.
European heart journal 2007;28(15):1894-903.
2007: Daniel Strbian; Marja-Liisa Karjalainen-Lindsberg; Petri T Kovanen; Turgut Tatlisumak; Perttu J Lindsberg
Mast cell stabilization reduces hemorrhage formation and mortality after administration of thrombolytics in experimental ischemic stroke.
Circulation 2007;116(4):411-8.
2007: Ken A Lindstedt; Mikko I Mäyränpää; Petri T Kovanen
Mast cells in vulnerable atherosclerotic plaques--a view to a kill.
Journal of cellular and molecular medicine 2007;11(4):739-58.
2007: Charlotta Sandler; Ken A Lindstedt; Sirkka-Liisa Joutsiniemi; Jani Lappalainen; Timo Juutilainen; J Kolah; Petri T Kovanen; Kari K Eklund
Selective activation of mast cells in rheumatoid synovial tissue results in production of TNF-alpha, IL-1beta and IL-1Ra.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2007;56(6):230-9.
2007: Petri T Kovanen
Mast cells: multipotent local effector cells in atherothrombosis.
Immunological reviews 2007;217():105-22.
2007: Krista Nuotio; Pia Isoviita; Jani Saksi; Petra Ijäs; Janne Pitkäniemi; Riitta Sonninen; Lauri Soinne; eija saimanen; Oili Salonen; Petri T Kovanen; Markku Kaste; Perttu J Lindsberg
Adipophilin expression is increased in symptomatic carotid atherosclerosis: correlation with red blood cells and cholesterol crystals.
Stroke; a journal of cerebral circulation 2007;38(6):1791-8.
2007: Aino Soro-Paavonen; Jussi Naukkarinen; Miriam Lee-Rueckert; Hiroshi Watanabe; Elina Rantala; Sanni Soderlund; Anne Hiukka; Petri T Kovanen; Matti Jauhiainen; Leena Peltonen; Marja-Riitta Taskinen
Common ABCA1 variants, HDL levels, and cellular cholesterol efflux in subjects with familial low HDL.
Journal of lipid research 2007;48(6):1409-16.
2007: Riia Kaakinen; Ken A Lindstedt; Mia Sneck; Petri T Kovanen; Katariina Öörni
Angiotensin II increases expression and secretion of cathepsin F in cultured human monocyte-derived macrophages: an angiotensin II type 2 receptor-mediated effect.
Atherosclerosis 2007;192(2):323-7.
2007: Riina Oksjoki; Petri T Kovanen; Mikko I Mäyränpää; Petri Laine; Anna M Blom; Seppo Meri; Markku O Pentikäinen
Complement regulation in human atherosclerotic coronary lesions. Immunohistochemical evidence that C4b-binding protein negatively regulates the classical complement pathway, and that C5b-9 is formed via the alternative complement pathway.
Atherosclerosis 2007;192(1):40-8.
2007: Satu Helske; Petri T Kovanen; Ken A Lindstedt; Kaija Salmela; Jyri Lommi; Heikki Turto; Kalervo Werkkala; Markku Kupari
Increased circulating concentrations and augmented myocardial extraction of osteoprotegerin in heart failure due to left ventricular pressure overload.
European journal of heart failure 2007;9(4):357-63.
2007: Mikko I Mäyränpää; Julio C Reséndiz; Hanna M Heikkilä; Ken A Lindstedt; Petri T Kovanen
Improved identification of endothelial erosion by simultaneous detection of endothelial cells (CD31/CD34) and platelets (CD42b).
Endothelium : journal of endothelial cell research 2007;14(2):81-7.
2007: Katariina Öörni; Petri T Kovanen
PLA2-V: a real player in atherogenesis.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(3):445-7.
2007: José Ruiz-Jiménez; Ruth Kuldvee; Jie Chen; Katariina Öörni; Petri T Kovanen; Marja-Liisa Riekkola
Open tubular CE for in vitro oxidation studies of human very-low-density lipoprotein particles.
Electrophoresis 2007;28(5):779-88.
2007: Elda Favari; Monica Gomaraschi; Ilaria Zanotti; Franco Bernini; Miriam Lee-Rueckert; Petri T Kovanen; Cesare R Sirtori; Guido Franceschini; Laura Calabresi
A unique protease-sensitive high density lipoprotein particle containing the apolipoprotein A-I(Milano) dimer effectively promotes ATP-binding Cassette A1-mediated cell cholesterol efflux.
The Journal of biological chemistry 2007;282(8):5125-32.
2007: Riina Oksjoki; Petri T Kovanen; Seppo Meri; Markku O Pentikainen
Function and regulation of the complement system in cardiovascular diseases.
Frontiers in bioscience : a journal and virtual library 2007;12():4696-708.
2007: Petra Ijäs; Krista Nuotio; Jani Saksi; Lauri Soinne; eija saimanen; Marja-Liisa Karjalainen-Lindsberg; Oili Salonen; Seppo Sarna; Jarno Tuimala; Petri T Kovanen; Markku Kaste; Perttu J Lindsberg
Microarray analysis reveals overexpression of CD163 and HO-1 in symptomatic carotid plaques.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(1):154-60.
2007: Krista Nuotio; Mikko I Mäyränpää; Jani Saksi; Petra Ijas; Tiina Sairanen; Olli Carpén; Lauri Soinne; eija saimanen; Oili Salonen; Mauri Lepäntalo; Petri T Kovanen; Markku Kaste; Perttu J Lindsberg
Endothelial apoptosis does not determine symptom status in carotid artery disease.
Cerebrovascular diseases (Basel, Switzerland) 2007;23(1):27-34.
2006: Mikko I Mäyränpää; Hanna M Heikkilä; Ken A Lindstedt; Andrew F Walls; Petri T Kovanen
Desquamation of human coronary artery endothelium by human mast cell proteases: implications for plaque erosion.
Coronary artery disease 2006;17(7):611-21.
2006: Jukka K Hakala; Ken A Lindstedt; Petri T Kovanen; Markku O Pentikäinen
Low-density lipoprotein modified by macrophage-derived lysosomal hydrolases induces expression and secretion of IL-8 via p38 MAPK and NF-kappaB by human monocyte-derived macrophages.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(11):2504-9.
2006: Miriam Lee-Rueckert; Petri T Kovanen
Mast cell proteases: physiological tools to study functional significance of high density lipoproteins in the initiation of reverse cholesterol transport.
Atherosclerosis 2006;189(1):8-18.
2006: Katariina Öörni; Petri T Kovanen
Enhanced extracellular lipid accumulation in acidic environments.
Current opinion in lipidology 2006;17(5):534-40.
2006: Ilpo Koskivirta; Otto Rahkonen; Mikko I Mäyränpää; Sari Pakkanen; Michael Husheem; Annele Sainio; Harri Hakovirta; Jukka Laine; Eero Jokinen; Eero Vuorio; Petri T Kovanen; Hannu Järveläinen
Tissue inhibitor of metalloproteinases 4 (TIMP4) is involved in inflammatory processes of human cardiovascular pathology.
Histochemistry and cell biology 2006;126(3):335-42.
2006: Charlotta Sandler; Sirkka-Liisa Joutsiniemi; Ken A Lindstedt; Timo Juutilainen; Petri T Kovanen; Kari K Eklund
Imatinib mesylate inhibits platelet derived growth factor stimulated proliferation of rheumatoid synovial fibroblasts.
Biochemical and biophysical research communications 2006;347(1):31-5.
2006: Satu Helske; Suvi Syväranta; Ken A Lindstedt; Jani Lappalainen; Katariina Öörni; Mikko I Mäyränpää; Jyri Lommi; Heikki Turto; Kalervo Werkkala; Markku Kupari; Petri T Kovanen
Increased expression of elastolytic cathepsins S, K, and V and their inhibitor cystatin C in stenotic aortic valves.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(8):1791-8.
2006: Miriam Lee-Rueckert; Riikka Vikstedt; Jari Metso; Christian Ehnholm; Petri T Kovanen; Matti Jauhiainen
Absence of endogenous phospholipid transfer protein impairs ABCA1-dependent efflux of cholesterol from macrophage foam cells.
Journal of lipid research 2006;47(8):1725-32.
2006: Gebrenegus Yohannes; Mia Sneck; Sami J O Varjo; Matti Jussila; Susanne K Wiedmer; Petri T Kovanen; Katariina Öörni; Marja-Liisa Riekkola
Miniaturization of asymmetrical flow field-flow fractionation and application to studies on lipoprotein aggregation and fusion.
Analytical biochemistry 2006;354(2):255-65.
2006: Satu Helske; Suvi Syväranta; Markku Kupari; Jani Lappalainen; Mika Laine; Jyri Lommi; Heikki Turto; Mikko I Mäyränpää; Kalervo Werkkala; Petri T Kovanen; Ken A Lindstedt
Possible role for mast cell-derived cathepsin G in the adverse remodelling of stenotic aortic valves.
European heart journal 2006;27(12):1495-504.
2006: Petru Liuba; Erkki Pesonen; Anders Forslid; Ilari Paakkari; Axel Kornerup-Hansen; Petri T Kovanen; Markku O Pentikäinen; Kenneth Persson; Grete Østergård
Protective effects of simvastatin on coronary artery function in swine with acute infection.
Atherosclerosis 2006;186(2):331-6.
2006: Markus J Leskinen; Hanna M Heikkilä; Mei Y Speer; Jukka K Hakala; Mika Laine; Petri T Kovanen; Ken A Lindstedt
Mast cell chymase induces smooth muscle cell apoptosis by disrupting NF-kappaB-mediated survival signaling.
Experimental cell research 2006;312(8):1289-98.
2006: Ruth Kuldvee; Lucia D'ulivo; Gebrenegus Yohannes; Petrus W Lindenburg; Minna Laine; Katariina Öörni; Petri T Kovanen; Marja-Liisa Riekkola
Open tubular capillary electrochromatography: technique for oxidation and interaction studies on human low-density lipoproteins.
Analytical chemistry 2006;78(8):2665-71.
2006: Leena Tenkanen; Matti Mänttäri; Petri T Kovanen; Hanna Virkkunen; Vesa Manninen
Gemfibrozil in the treatment of dyslipidemia: an 18-year mortality follow-up of the Helsinki Heart Study.
Archives of internal medicine 2006;166(7):743-8.
2006: Katri Niemi; Marc H Baumann; Petri T Kovanen; Kari K Eklund
Serum amyloid A (SAA) activates human mast cells which leads into degradation of SAA and generation of an amyloidogenic SAA fragment.
Biochimica et biophysica acta 2006;1762(4):424-30.
2006: Riina Oksjoki; Petri T Kovanen; Ken A Lindstedt; Bo Jansson; Markku O Pentikäinen
OxLDL-IgG immune complexes induce survival of human monocytes.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(3):576-83.
2006: Ken A Lindstedt; Petri T Kovanen
Isolation of mast cell granules.
Current protocols in cell biology / editorial board, Juan S. Bonifacino ... [et al.] 2006;Chapter 3():Unit 3.16.
2006: Ari Palomäki; Petri T Kovanen
[Not Available].
Duodecim; lääketieteellinen aikakauskirja 2006;122(14):1747-56.
2006: Ahmed Salem Ali; Anna-Satina Lax; Mikko Liljeström; Ilari Paakkari; Nureddin Ashammakhi; Petri T Kovanen; Yrjö T Konttinen
Mast cells in atherosclerosis as a source of the cytokine RANKL.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2006;44(5):672-4.
2006: Markku Laakso; Petri T Kovanen
Metabolic syndrome: to be or not to be?
Annals of medicine 2006;38(1):32-3.
2005: Mia Sneck; Petri T Kovanen; Katariina Öörni
Decrease in pH strongly enhances binding of native, proteolyzed, lipolyzed, and oxidized low density lipoprotein particles to human aortic proteoglycans.
The Journal of biological chemistry 2005;280(45):37449-54.
2005: Charlotta Sandler; Katariina Nurmi; Ken A Lindstedt; Timo Sorsa; Lorne M Golub; Petri T Kovanen; Kari K Eklund
Chemically modified tetracyclines induce apoptosis in cultured mast cells.
International immunopharmacology 2005;5(11):1611-21.
2005: Helena Kervinen; Maija Kaartinen; Heikki Mäkynen; Timo Palosuo; Matti Mänttäri; Petri T Kovanen
Serum tryptase levels in acute coronary syndromes.
International journal of cardiology 2005;104(2):138-43.
2005: A Juurikivi; Charlotta Sandler; Ken A Lindstedt; Petri T Kovanen; Timo Juutilainen; Markus J Leskinen; Tiina Mäki; Kari K Eklund
Inhibition of c-kit tyrosine kinase by imatinib mesylate induces apoptosis in mast cells in rheumatoid synovia: a potential approach to the treatment of arthritis.
Annals of the rheumatic diseases 2005;64(8):1126-31.
2005: Katariina Öörni; Pirjo Posio; Mika Ala-Korpela; Matti Jauhiainen; Petri T Kovanen
Sphingomyelinase induces aggregation and fusion of small very low-density lipoprotein and intermediate-density lipoprotein particles and increases their retention to human arterial proteoglycans.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(8):1678-83.
2005: Charlotta Sandler; Elina Ekokoski; Ken A Lindstedt; Petri J Vainio; Moshe Finel; Timo Sorsa; Petri T Kovanen; Lorne M Golub; Kari K Eklund
Chemically modified tetracycline (CMT)-3 inhibits histamine release and cytokine production in mast cells: possible involvement of protein kinase C.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2005;54(7):304-12.
2005: Marja T Hyvönen; Petri T Kovanen
Molecular dynamics simulations of unsaturated lipid bilayers: effects of varying the numbers of double bonds.
European biophysics journal : EBJ 2005;34(4):294-305.
2005: inka liesmaa; Antti Kuoppala; Naotaka Shiota; Jorma O Kokkonen; Karam Kostner; Mikko I Mäyränpää; Petri T Kovanen; Ken A Lindstedt
Increased expression of bradykinin type-1 receptors in endothelium of intramyocardial coronary vessels in human failing hearts.
American journal of physiology. Heart and circulatory physiology 2005;288(5):H2317-22.
2005: Sanna Taskinen; Marja T Hyvönen; Petri T Kovanen; Seppo Meri; Markku O Pentikäinen
C-reactive protein binds to the 3beta-OH group of cholesterol in LDL particles.
Biochemical and biophysical research communications 2005;329(4):1208-16.
2005: Lauri Soinne; eija saimanen; Kirsi Malmberg-Céder; Petri T Kovanen; Perttu J Lindsberg; Markku Kaste; Riitta Lassila
Association of the fibrinolytic system and hemorheology with symptoms in patients with carotid occlusive disease.
Cerebrovascular diseases (Basel, Switzerland) 2005;20(3):172-9.
2005: Satu Helske; Ken A Lindstedt; Petri T Kovanen
[Calcified aortic valve stenosis, could the process be prevented?].
Duodecim; lääketieteellinen aikakauskirja 2005;121(11):1195-7.
2005: Petri T Kovanen; Markku O Pentikäinen
[Intensive lipid lowering statin therapy immediately after acute coronary syndrome].
Duodecim; lääketieteellinen aikakauskirja 2005;121(10):1029-32.
2005: Erno M P Lehtonen-Smeds; Mikko Mayranpaa; Perttu J Lindsberg; Lauri Soinne; eija saimanen; Antero A J Jarvinen; Oili Salonen; Olli Carpén; Riitta Lassila; Seppo Sarna; Markku Kaste; Petri T Kovanen
Carotid plaque mast cells associate with atherogenic serum lipids, high grade carotid stenosis and symptomatic carotid artery disease. Results from the helsinki carotid endarterectomy study.
Cerebrovascular diseases (Basel, Switzerland) 2005;19(5):291-301.
2005: Marjut Otala; Markku O Pentikäinen; Tiina Matikainen; Laura Suomalainen; Jukka K Hakala; Gloria I Perez; Mikko Tenhunen; Krista Erkkilä; Petri T Kovanen; Martti Parvinen; Leo Dunkel
Effects of acid sphingomyelinase deficiency on male germ cell development and programmed cell death.
Biology of reproduction 2005;72(1):86-96.
2004: Ken A Lindstedt; Petri T Kovanen
Proteolysis of pericellular matrix: a process linking inflammation to plaque destabilization and rupture.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(12):2205-6.
2004: Satu Helske; Ken A Lindstedt; Mika Laine; Mikko I Mäyränpää; Kalervo Werkkala; Jyri Lommi; Heikki Turto; Markku Kupari; Petri T Kovanen
Induction of local angiotensin II-producing systems in stenotic aortic valves.
Journal of the American College of Cardiology 2004;44(9):1859-66.
2004: Helena Kervinen; Matti Mänttäri; Maija Kaartinen; Heikki Mäkynen; Timo Palosuo; Kari Pulkki; Petri T Kovanen
Prognostic usefulness of plasma monocyte/macrophage and T-lymphocyte activation markers in patients with acute coronary syndromes.
The American journal of cardiology 2004;94(8):993-6.
2004: Ken A Lindstedt; Petri T Kovanen
Mast cells in vulnerable coronary plaques: potential mechanisms linking mast cell activation to plaque erosion and rupture.
Current opinion in lipidology 2004;15(5):567-73.
2004: Jan Nilsson; Petri T Kovanen
Will autoantibodies help to determine severity and progression of atherosclerosis?
Current opinion in lipidology 2004;15(5):499-503.
2004: Helena Lappalainen; Petri Laine; Markku O Pentikäinen; Antti Sajantila; Petri T Kovanen
Mast cells in neovascularized human coronary plaques store and secrete basic fibroblast growth factor, a potent angiogenic mediator.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(10):1880-5.
2004: Katariina Öörni; Mia Sneck; Dieter Brömme; Markku O Pentikäinen; Ken A Lindstedt; Mikko I Mäyränpää; Helena Aitio; Petri T Kovanen
Cysteine protease cathepsin F is expressed in human atherosclerotic lesions, is secreted by cultured macrophages, and modifies low density lipoprotein particles in vitro.
The Journal of biological chemistry 2004;279(33):34776-84.
2004: Ken A Lindstedt; Markus J Leskinen; Petri T Kovanen
Proteolysis of the pericellular matrix: a novel element determining cell survival and death in the pathogenesis of plaque erosion and rupture.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(8):1350-8.
2004: Alpo F Vuorio; Petri T Kovanen; Helena Gylling
Hypolipidemic treatment of heterozygous familial hypercholesterolemia: a lifelong challenge.
Expert review of cardiovascular therapy 2004;2(3):405-15.
2004: Mikko I Mäyränpää; Jarmo Simpanen; Michael W Hess; Kalervo Werkkala; Petri T Kovanen
Arterial endothelial denudation by intraluminal use of papaverine-NaCl solution in coronary bypass surgery.
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 2004;25(4):560-6.
2004: Elda Favari; Miriam Lee; Laura Calabresi; Guido Franceschini; Francesca Zimetti; Franco Bernini; Petri T Kovanen
Depletion of pre-beta-high density lipoprotein by human chymase impairs ATP-binding cassette transporter A1- but not scavenger receptor class B type I-mediated lipid efflux to high density lipoprotein.
The Journal of biological chemistry 2004;279(11):9930-6.
2004: Marjut Otala; Laura Suomalainen; Markku O Pentikäinen; Petri T Kovanen; Mikko Tenhunen; Krista Erkkilä; Jorma Toppari; Leo Dunkel
Protection from radiation-induced male germ cell loss by sphingosine-1-phosphate.
Biology of reproduction 2004;70(3):759-67.
2004: Petri T Kovanen
[Mast cells in coronary arteries-an immune cell at a wrong address?].
Duodecim; lääketieteellinen aikakauskirja 2004;120(2):126-37.
2003: Leena Lindstedt; Miriam Lee; Katariina Öörni; Dieter Brömme; Petri T Kovanen
Cathepsins F and S block HDL3-induced cholesterol efflux from macrophage foam cells.
Biochemical and biophysical research communications 2003;312(4):1019-24.
2003: Markus J Leskinen; Petri T Kovanen; Ken A Lindstedt
Regulation of smooth muscle cell growth, function and death in vitro by activated mast cells--a potential mechanism for the weakening and rupture of atherosclerotic plaques.
Biochemical pharmacology 2003;66(8):1493-8.
2003: Naotaka Shiota; Jaana Rysä; Petri T Kovanen; Heikki Ruskoaho; Jorma O Kokkonen; Ken A Lindstedt
A role for cardiac mast cells in the pathogenesis of hypertensive heart disease.
Journal of hypertension 2003;21(10):1935-44.
2003: Riina Oksjoki; Petri T Kovanen; Markku O Pentikäinen
Role of complement activation in atherosclerosis.
Current opinion in lipidology 2003;14(5):477-82.
2003: Petri T Kovanen; Markku O Pentikäinen
Circulating lipoproteins as proinflammatory and anti-inflammatory particles in atherogenesis.
Current opinion in lipidology 2003;14(5):411-9.
2003: Antti Kuoppala; Naotaka Shiota; Ken A Lindstedt; Jaana Rysä; Hanna Leskinen; Marja Luodonpää; inka liesmaa; Heikki Ruskoaho; Risto Kaaja; Petri T Kovanen; Jorma O Kokkonen
Expression of bradykinin receptors in the left ventricles of rats with pressure overload hypertrophy and heart failure.
Journal of hypertension 2003;21(9):1729-36.
2003: Jukka K Hakala; Riina Oksjoki; Petri Laine; Hong Du; Gregory A Grabowski; Petri T Kovanen; Markku O Pentikäinen
Lysosomal enzymes are released from cultured human macrophages, hydrolyze LDL in vitro, and are present extracellularly in human atherosclerotic lesions.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(8):1430-6.
2003: Krista Nuotio; Perttu J Lindsberg; Olli Carpén; Lauri Soinne; E M P Lehtonen-Smeds; eija saimanen; Riitta Lassila; Tiina Sairanen; Seppo Sarna; Oili Salonen; Petri T Kovanen; Markku Kaste
Adhesion molecule expression in symptomatic and asymptomatic carotid stenosis.
Neurology 2003;60(12):1890-9.
2003: Jorma O Kokkonen; Ken A Lindstedt; Petri T Kovanen
Role for chymase in heart failure: angiotensin II-dependent or -independent mechanisms?
Circulation 2003;107(20):2522-4.
2003: Miriam Lee; Jari Metso; Matti Jauhiainen; Petri T Kovanen
Degradation of phospholipid transfer protein (PLTP) and PLTP-generated pre-beta-high density lipoprotein by mast cell chymase impairs high affinity efflux of cholesterol from macrophage foam cells.
The Journal of biological chemistry 2003;278(15):13539-45.
2003: Petru Liuba; Erkki Pesonen; Ilari Paakkari; satish c batra; Anders Forslid; Petri T Kovanen; Markku O Pentikäinen; Kenneth Persson; Staffan Sandström
Acute Chlamydia pneumoniae infection causes coronary endothelial dysfunction in pigs.
Atherosclerosis 2003;167(2):215-22.
2003: Riina Oksjoki; Hanna Jarva; Petri T Kovanen; Petri Laine; Seppo Meri; Markku O Pentikäinen
Association between complement factor H and proteoglycans in early human coronary atherosclerotic lesions: implications for local regulation of complement activation.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(4):630-6.
2003: Paul Cullen; Roberta Baetta; Stefano Bellosta; Franco Bernini; Giulia Chinetti; Andrea Cignarella; Arnold von Eckardstein; Andrew Exley; Martin Goddard; Marten H Hofker; Eva Hurt-Camejo; Edwin Kanters; Petri T Kovanen; Stefan Lorkowski; William McPheat; Markku O Pentikäinen; Jürgen Rauterberg; Andrew Ritchie; Bart Staels; Benedikt Weitkamp; Menno de Winther
Rupture of the atherosclerotic plaque: does a good animal model exist?
Arteriosclerosis, thrombosis, and vascular biology 2003;23(4):535-42.
2003: Soili Lätti; Markus J Leskinen; Naotaka Shiota; Yenfeng Wang; Petri T Kovanen; Ken A Lindstedt
Mast cell-mediated apoptosis of endothelial cells in vitro: a paracrine mechanism involving TNF-alpha-mediated down-regulation of bcl-2 expression.
Journal of cellular physiology 2003;195(1):130-8.
2003: Miriam Lee; Petri T Kovanen; Gabriella Tedeschi; Emanuela Oungre; Guido Franceschini; Laura Calabresi
Apolipoprotein composition and particle size affect HDL degradation by chymase: effect on cellular cholesterol efflux.
Journal of lipid research 2003;44(3):539-46.
2003: Petri T Kovanen; Markku O Pentikäinen
Pharmacological evidence for a role of liver X receptors in atheroprotection.
FEBS letters 2003;536(1-3):3-5.
2003: Markus J Leskinen; Ken A Lindstedt; Yenfeng Wang; Petri T Kovanen
Mast cell chymase induces smooth muscle cell apoptosis by a mechanism involving fibronectin degradation and disruption of focal adhesions.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(2):238-43.
2003: Matti Mänttäri; Petri T Kovanen
[C-reactive protein--the most important risk factors of atherosclerosis?].
Duodecim; lääketieteellinen aikakauskirja 2003;119(18):1701-3.
2002: Miriam Lee; Christian P Sommerhoff; Arnold von Eckardstein; Frank Zettl; Hans Fritz; Petri T Kovanen
Mast cell tryptase degrades HDL and blocks its function as an acceptor of cellular cholesterol.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(12):2086-91.
2002: Sanna Taskinen; Petri T Kovanen; Hanna Jarva; Seppo Meri; Markku O Pentikäinen
Binding of C-reactive protein to modified low-density-lipoprotein particles: identification of cholesterol as a novel ligand for C-reactive protein.
The Biochemical journal 2002;367(Pt 2):403-12.
2002: Miriam Lee; Laura Calabresi; Giulia Chiesa; Guido Franceschini; Petri T Kovanen
Mast cell chymase degrades apoE and apoA-II in apoA-I-knockout mouse plasma and reduces its ability to promote cellular cholesterol efflux.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(9):1475-81.
2002: Juha Vakkilainen; Päivi Pajukanta; Rita M Cantor; Ilpo Nuotio; Sanni Lahdenperä; Kati Ylitalo; Jussi Pihlajamäki; Petri T Kovanen; Markku Laakso; Jorma S A Viikari; Leena Peltonen; Marja-Riitta Taskinen
Genetic influences contributing to LDL particle size in familial combined hyperlipidaemia.
European journal of human genetics : EJHG 2002;10(9):547-52.
2002: Petri Laine; Markku O Pentikäinen; Reinhard Wurzner; Antti Penttilä; Timo Paavonen; Seppo Meri; Petri T Kovanen
Evidence for complement activation in ruptured coronary plaques in acute myocardial infarction.
The American journal of cardiology 2002;90(4):404-8.
2002: Antti Kuoppala; Naotaka Shiota; Jorma O Kokkonen; inka liesmaa; Karam Kostner; Mikko I Mäyränpää; Petri T Kovanen; Ken A Lindstedt
Down-regulation of cardioprotective bradykinin type-2 receptors in the left ventricle of patients with end-stage heart failure.
Journal of the American College of Cardiology 2002;40(1):119-25.
2002: Kaj Metsärinne; Pirjo Vehmaan-Kreula; Petri T Kovanen; Outi Saijonmaa; Marc Baumann; Yenfeng Wang; Tuulikki Nyman; Frej Fyhrquist; Kari K Eklund
Activated mast cells increase the level of endothelin-1 mRNA in cocultured endothelial cells and degrade the secreted Peptide.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(2):268-73.
2002: Markku O Pentikäinen; Riina Oksjoki; Katariina Öörni; Petri T Kovanen
Lipoprotein lipase in the arterial wall: linking LDL to the arterial extracellular matrix and much more.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(2):211-7.
2001: Yenfeng Wang; Naotaka Shiota; Markus J Leskinen; Ken A Lindstedt; Petri T Kovanen
Mast cell chymase inhibits smooth muscle cell growth and collagen expression in vitro: transforming growth factor-beta1-dependent and -independent effects.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(12):1928-33.
2001: Markku O Pentikäinen; Katariina Öörni; Petri T Kovanen
Myeloperoxidase and hypochlorite, but not copper ions, oxidize heparin-bound LDL particles and release them from heparin.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(12):1902-8.
2001: Alpo F Vuorio; Katriina Aalto-Setälä; UM Koivisto; Hannu Turtola; H Nissen; Petri T Kovanen; Tatu A Miettinen; Helena Gylling; Hanna Oksanen; Kimmo Kontula
Familial hypercholesterolaemia in Finland: common, rare and mild mutations of the LDL receptor and their clinical consequences. Finnish FH-group.
Annals of medicine 2001;33(6):410-21.
2001: Jukka K Hakala; Katariina Öörni; Markku O Pentikäinen; Eva Hurt-Camejo; Petri T Kovanen
Lipolysis of LDL by human secretory phospholipase A(2) induces particle fusion and enhances the retention of LDL to human aortic proteoglycans.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(6):1053-8.
2001: Ken A Lindstedt; Yenfeng Wang; Naotaka Shiota; J Saarinen; Marko Hyytiäinen; Jorma O Kokkonen; Jorma Keski-Oja; Petri T Kovanen
Activation of paracrine TGF-beta1 signaling upon stimulation and degranulation of rat serosal mast cells: a novel function for chymase.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(8):1377-88.
2001: Markku O Pentikäinen; Marja T Hyvönen; Katariina Öörni; T Hevonoja; Arja Korhonen; E M Lehtonen-Smeds; Mika Ala-Korpela; Petri T Kovanen
Altered phospholipid-apoB-100 interactions and generation of extra membrane material in proteolysis-induced fusion of LDL particles.
Journal of lipid research 2001;42(6):916-22.
2001: Markus J Leskinen; Yenfeng Wang; Dariusz Leszczynski; Ken A Lindstedt; Petri T Kovanen
Mast cell chymase induces apoptosis of vascular smooth muscle cells.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(4):516-22.
2001: L Lindstedt; Miriam Lee; Petri T Kovanen
Chymase bound to heparin is resistant to its natural inhibitors and capable of proteolyzing high density lipoproteins in aortic intimal fluid.
Atherosclerosis 2001;155(1):87-97.
2001: Heidi Jänkälä; Kari K Eklund; J O Kokkonen; Petri T Kovanen; K A Linstedt; Matti Härkönen; Tiina Mäki
Ethanol infusion increases ANP and p21 gene expression in isolated perfused rat heart.
Biochemical and biophysical research communications 2001;281(2):328-33.
2001: Marja T Hyvönen; Yrjö Hiltunen; W El-Deredy; T Ojala; J Vaara; Petri T Kovanen; Mika Ala-Korpela
Application of self-organizing maps in conformational analysis of lipids.
Journal of the American Chemical Society 2001;123(5):810-6.
2001: Marja T Hyvönen; Katariina Öörni; Petri T Kovanen; Mika Ala-Korpela
Changes in a phospholipid bilayer induced by the hydrolysis of a phospholipase A2 enzyme: a molecular dynamics simulation study.
Biophysical journal 2001;80(2):565-78.
2001: P Vehmaan-Kreula; Mirja Puolakkainen; Matti Sarvas; HG Welgus; Petri T Kovanen
Chlamydia pneumoniae proteins induce secretion of the 92-kDa gelatinase by human monocyte- derived macrophages.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(1):E1-8.
2000: H Ma; Petri T Kovanen
Inhibition of mast cell-dependent conversion of cultured macrophages into foam cells with antiallergic drugs.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(12):E134-42.
2000: T Hevonoja; Markku O Pentikäinen; Marja T Hyvönen; Petri T Kovanen; Mika Ala-Korpela
Structure of low density lipoprotein (LDL) particles: basis for understanding molecular changes in modified LDL.
Biochimica et biophysica acta 2000;1488(3):189-210.
2000: Petteri Kauhanen; Petri T Kovanen; Riitta Lassila
Coimmobilized native macromolecular heparin proteoglycans strongly inhibit platelet-collagen interactions in flowing blood.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(11):E113-9.
2000: Katariina Öörni; Markku O Pentikäinen; Mika Ala-Korpela; Petri T Kovanen
Aggregation, fusion, and vesicle formation of modified low density lipoprotein particles: molecular mechanisms and effects on matrix interactions.
Journal of lipid research 2000;41(11):1703-14.
2000: Petri T Kovanen; M K Lindstedt; Naotaka Shiota; Jorma O Kokkonen
Chymase-dependent angiotensin II formation in human vascular tissue.
Circulation 2000;102(4):E32.
2000: Miriam Lee; Patrizia Uboldi; D Giudice; Alberico L Catapano; Petri T Kovanen
Identification of domains in apoA-I susceptible to proteolysis by mast cell chymase. Implications for HDL function.
Journal of lipid research 2000;41(6):975-84.
2000: Petri Laine; A Naukkarinen; L Heikkilä; Antti Penttilä; Petri T Kovanen
Adventitial mast cells connect with sensory nerve fibers in atherosclerotic coronary arteries.
Circulation 2000;101(14):1665-9.
2000: Antti Kuoppala; Ken A Lindstedt; J Saarinen; Petri T Kovanen; Jorma O Kokkonen
Inactivation of bradykinin by angiotensin-converting enzyme and by carboxypeptidase N in human plasma.
American journal of physiology. Heart and circulatory physiology 2000;278(4):H1069-74.
2000: Jorma O Kokkonen; Ken A Lindstedt; Antti Kuoppala; Petri T Kovanen
Kinin-degrading pathways in the human heart.
Trends in cardiovascular medicine 2000;10(1):42-5.
1999: A Santala; J Saarinen; Petri T Kovanen; Pentti Kuusela
Activation of interstitial collagenase, MMP-1, by Staphylococcus aureus cells having surface-bound plasmin: a novel role of plasminogen receptors of bacteria.
FEBS letters 1999;461(3):153-6.
1999: L Lindstedt; J Saarinen; Nisse Kalkkinen; HG Welgus; Petri T Kovanen
Matrix metalloproteinases-3, -7, and -12, but not -9, reduce high density lipoprotein-induced cholesterol efflux from human macrophage foam cells by truncation of the carboxyl terminus of apolipoprotein A-I. Parallel losses of pre-beta particles and the high affinity component of efflux.
The Journal of biological chemistry 1999;274(32):22627-34.
1999: Jukka K Hakala; Katariina Öörni; Mika Ala-Korpela; Petri T Kovanen
Lipolytic modification of LDL by phospholipase A2 induces particle aggregation in the absence and fusion in the presence of heparin.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(5):1276-83.
1999: Jorma O Kokkonen; Antti Kuoppala; J Saarinen; Ken A Lindstedt; Petri T Kovanen
Kallidin- and bradykinin-degrading pathways in human heart: degradation of kallidin by aminopeptidase M-like activity and bradykinin by neutral endopeptidase.
Circulation 1999;99(15):1984-90.
1999: Petri T Kovanen; Markku O Pentikäinen
Decorin links low-density lipoproteins (LDL) to collagen: a novel mechanism for retention of LDL in the atherosclerotic plaque.
Trends in cardiovascular medicine 1999;9(3-4):86-91.
1999: Miriam Lee; Arnold von Eckardstein; L Lindstedt; G Assmann; Petri T Kovanen
Depletion of pre beta 1LpA1 and LpA4 particles by mast cell chymase reduces cholesterol efflux from macrophage foam cells induced by plasma.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(4):1066-74.
1999: Petri Laine; M Kaartinen; Antti Penttilä; Pertti Panula; T Paavonen; Petri T Kovanen
Association between myocardial infarction and the mast cells in the adventitia of the infarct-related coronary artery.
Circulation 1999;99(3):361-9.
1999: Yenfeng Wang; Petri T Kovanen
Heparin proteoglycans released from rat serosal mast cells inhibit proliferation of rat aortic smooth muscle cells in culture.
Circulation research 1999;84(1):74-83.
1998: Ken A Lindstedt; Jorma O Kokkonen; Petri T Kovanen
Regulation of the activity of secreted human lung mast cell tryptase by mast cell proteoglycans.
Biochimica et biophysica acta 1998;1425(3):617-27.
1998: Katariina Öörni; Jukka K Hakala; A Annila; Mika Ala-Korpela; Petri T Kovanen
Sphingomyelinase induces aggregation and fusion, but phospholipase A2 only aggregation, of low density lipoprotein (LDL) particles. Two distinct mechanisms leading to increased binding strength of LDL to human aortic proteoglycans.
The Journal of biological chemistry 1998;273(44):29127-34.
1998: Maija Kaartinen; Allard C van der Wal; Chris M van der Loos; Jan J Piek; Karel T Koch; Anton E Becker; Petri T Kovanen
Mast cell infiltration in acute coronary syndromes: implications for plaque rupture.
Journal of the American College of Cardiology 1998;32(3):606-12.
1998: Arja Korhonen; M Jauhiainen; C Ehnholm; Petri T Kovanen; Mika Ala-Korpela
Remodeling of HDL by phospholipid transfer protein: demonstration of particle fusion by 1H NMR spectroscopy.
Biochemical and biophysical research communications 1998;249(3):910-6.
1998: Jorma O Kokkonen; J Saarinen; Petri T Kovanen
Angiotensin II formation in the human heart: an ACE or non-ACE-mediated pathway?
Annals of medicine 1998;30 Suppl 1():9-13.
1998: Mika Ala-Korpela; Markku O Pentikäinen; Arja Korhonen; T Hevonoja; J Lounila; Petri T Kovanen
Detection of low density lipoprotein particle fusion by proton nuclear magnetic resonance spectroscopy.
Journal of lipid research 1998;39(8):1705-12.
1998: Petri T Kovanen; Matti Mänttäri; Timo Palosuo; Vesa Manninen; K Aho
Prediction of myocardial infarction in dyslipidemic men by elevated levels of immunoglobulin classes A, E, and G, but not M.
Archives of internal medicine 1998;158(13):1434-9.
1998: Petteri Kauhanen; Petri T Kovanen; T Reunala; Riitta Lassila
Effects of skin mast cells on bleeding time and coagulation activation at the site of platelet plug formation.
Thrombosis and haemostasis 1998;79(4):843-7.
1997: Riitta Lassila; Ken A Lindstedt; Petri T Kovanen
Native macromolecular heparin proteoglycans exocytosed from stimulated rat serosal mast cells strongly inhibit platelet-collagen interactions.
Arteriosclerosis, thrombosis, and vascular biology 1997;17(12):3578-87.
1997: H Ma; Petri T Kovanen
Degranulation of cutaneous mast cells induces transendothelial transport and local accumulation of plasma LDL in rat skin in vivo.
Journal of lipid research 1997;38(9):1877-87.
1997: Kimmo Porkka; Ilpo Nuotio; Päivi Pajukanta; Christian Ehnholm; L Suurinkeroinen; Mikko Syvänne; Terho Lehtimäki; Anne-Tiina Lahdenkari; Sanni Lahdenperä; Kati Ylitalo; Marjatta Antikainen; Markus Perola; Olli T Raitakari; Petri T Kovanen; Jorma S A Viikari; Leena Peltonen; Marja-Riitta Taskinen
Phenotype expression in familial combined hyperlipidemia.
Atherosclerosis 1997;133(2):245-53.
1997: Katariina Öörni; Markku O Pentikäinen; A Annila; Petri T Kovanen
Oxidation of low density lipoprotein particles decreases their ability to bind to human aortic proteoglycans. Dependence on oxidative modification of the lysine residues.
The Journal of biological chemistry 1997;272(34):21303-11.
1997: Markku O Pentikäinen; Katariina Öörni; R Lassila; Petri T Kovanen
The proteoglycan decorin links low density lipoproteins with collagen type I.
The Journal of biological chemistry 1997;272(12):7633-8.
1997: Jorma O Kokkonen; J Saarinen; Petri T Kovanen
Regulation of local angiotensin II formation in the human heart in the presence of interstitial fluid. Inhibition of chymase by protease inhibitors of interstitial fluid and of angiotensin-converting enzyme by Ang-(1-9) formed by heart carboxypeptidase A-like activity.
Circulation 1997;95(6):1455-63.
1997: Petri T Kovanen
Chymase-containing mast cells in human arterial intima: implications for atherosclerotic disease.
Heart and vessels 1997;Suppl 12():125-7.
1996: Markku O Pentikäinen; E M Lehtonen; Petri T Kovanen
Aggregation and fusion of modified low density lipoprotein.
Journal of lipid research 1996;37(12):2638-49.
1996: M Kaartinen; A Penttilä; Petri T Kovanen
Mast cells in rupture-prone areas of human coronary atheromas produce and store TNF-alpha.
Circulation 1996;94(11):2787-92.
1996: Petri T Kovanen
Mast cells in human fatty streaks and atheromas: implications for intimal lipid accumulation.
Current opinion in lipidology 1996;7(5):281-6.
1996: Y Wang; Ken A Lindstedt; Petri T Kovanen
Phagocytosis of mast cell granule remnant-bound LDL by smooth muscle cells of synthetic phenotype: a scavenger receptor-mediated process that effectively stimulates cytoplasmic cholesteryl ester synthesis.
Journal of lipid research 1996;37(10):2155-66.
1996: M Kaartinen; A Penttilä; Petri T Kovanen
Mast cells accompany microvessels in human coronary atheromas: implications for intimal neovascularization and hemorrhage.
Atherosclerosis 1996;123(1-2):123-31.
1996: L Lindstedt; M Lee; G R Castro; J C Fruchart; Petri T Kovanen
Chymase in exocytosed rat mast cell granules effectively proteolyzes apolipoprotein AI-containing lipoproteins, so reducing the cholesterol efflux-inducing ability of serum and aortic intimal fluid.
The Journal of clinical investigation 1996;97(10):2174-82.
1995: M Kaartinen; A Penttilä; Petri T Kovanen
Extracellular mast cell granules carry apolipoprotein B-100-containing lipoproteins into phagocytes in human arterial intima. Functional coupling of exocytosis and phagodytosis in neighboring cells.
Arteriosclerosis, thrombosis, and vascular biology 1995;15(11):2047-54.
1995: Petri T Kovanen; M Kaartinen; T Paavonen
Infiltrates of activated mast cells at the site of coronary atheromatous erosion or rupture in myocardial infarction.
Circulation 1995;92(5):1084-8.
1995: M Piha; L Lindstedt; Petri T Kovanen
Fusion of proteolyzed low-density lipoprotein in the fluid phase: a novel mechanism generating atherogenic lipoprotein particles.
Biochemistry 1995;34(32):10120-9.
1995: H Ma; Petri T Kovanen
IgE-dependent generation of foam cells: an immune mechanism involving degranulation of sensitized mast cells with resultant uptake of LDL by macrophages.
Arteriosclerosis, thrombosis, and vascular biology 1995;15(6):811-9.
1995: Y Wang; Ken A Lindstedt; Petri T Kovanen
Mast cell granule remnants carry LDL into smooth muscle cells of the synthetic phenotype and induce their conversion into foam cells.
Arteriosclerosis, thrombosis, and vascular biology 1995;15(6):801-10.
1995: Markku O Pentikäinen; Ken A Lindstedt; Petri T Kovanen
Inhibition of the oxidative modification of LDL by nitecapone.
Arteriosclerosis, thrombosis, and vascular biology 1995;15(6):740-7.
1995: K Paananen; J Saarinen; A Annila; Petri T Kovanen
Proteolysis and fusion of low density lipoprotein particles strengthen their binding to human aortic proteoglycans.
The Journal of biological chemistry 1995;270(20):12257-62.
1995: Petri T Kovanen
Role of mast cells in atherosclerosis.
Chemical immunology 1995;62():132-70.
1994: M Kaartinen; A Penttilä; Petri T Kovanen
Accumulation of activated mast cells in the shoulder region of human coronary atheroma, the predilection site of atheromatous rupture.
Circulation 1994;90(4):1669-78.
1994: J Saarinen; N Kalkkinen; H G Welgus; Petri T Kovanen
Activation of human interstitial procollagenase through direct cleavage of the Leu83-Thr84 bond by mast cell chymase.
The Journal of biological chemistry 1994;269(27):18134-40.
1994: M Kaartinen; A Penttilä; Petri T Kovanen
Mast cells of two types differing in neutral protease composition in the human aortic intima. Demonstration of tryptase- and tryptase/chymase-containing mast cells in normal intimas, fatty streaks, and the shoulder region of atheromas.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1994;14(6):966-72.
1994: K Paananen; Petri T Kovanen
Proteolysis and fusion of low density lipoprotein particles independently strengthen their binding to exocytosed mast cell granules.
The Journal of biological chemistry 1994;269(3):2023-31.
1993: Petri T Kovanen
The mast cell--a potential link between inflammation and cellular cholesterol deposition in atherogenesis.
European heart journal 1993;14 Suppl K():105-17.
1993: Jorma O Kokkonen; Ken A Lindstedt; Petri T Kovanen
Metabolism of LDL in mast cells recovering from degranulation. Description of a novel intracellular pathway leading to proteolytic modification of the lipoprotein.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1993;13(2):276-85.
1993: Ken A Lindstedt; Jorma O Kokkonen; Petri T Kovanen
Inhibition of copper-mediated oxidation of LDL by rat serosal mast cells. A novel cellular protective mechanism involving proteolysis of the substrate under oxidative stress.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1993;13(1):23-32.
1992: M Lee; L K Lindstedt; Petri T Kovanen
Mast cell-mediated inhibition of reverse cholesterol transport.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1992;12(11):1329-35.
1992: Ken A Lindstedt; Jorma O Kokkonen; Petri T Kovanen
Soluble heparin proteoglycans released from stimulated mast cells induce uptake of low density lipoproteins by macrophages via scavenger receptor-mediated phagocytosis.
Journal of lipid research 1992;33(1):65-75.
1991: Petri T Kovanen; Jorma O Kokkonen
Modification of low density lipoproteins by secretory granules of rat serosal mast cells.
The Journal of biological chemistry 1991;266(7):4430-6.
1991: Petri T Kovanen
Mast cell granule-mediated uptake of low density lipoproteins by macrophages: a novel carrier mechanism leading to the formation of foam cells.
Annals of medicine 1991;23(5):551-9.
1990: Petri T Kovanen
Atheroma formation: defective control in the intimal round-trip of cholesterol.
European heart journal 1990;11 Suppl E():238-46.
1990: Jorma O Kokkonen; Petri T Kovanen
The metabolism of low density lipoproteins by rat serosal mast cells.
European heart journal 1990;11 Suppl E():134-46.
1989: Jorma O Kokkonen; Petri T Kovanen
Accumulation of low density lipoproteins in stimulated rat serosal mast cells during recovery from degranulation.
Journal of lipid research 1989;30(9):1341-8.
1989: Jorma O Kokkonen; Petri T Kovanen
Proteolytic enzymes of mast cell granules degrade low density lipoproteins and promote their granule-mediated uptake by macrophages in vitro.
The Journal of biological chemistry 1989;264(18):10749-55.