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Karl-Artur Kovar

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Karsten Heekeren; Anna Neukirch; Joerg Daumann; Martina Stoll; Maja Obradovic; Karl-Artur Kovar; Mark A Geyer; Euphrosyne Gouzoulis-Mayfrank
Prepulse inhibition of the startle reflex and its attentional modulation in the human S-ketamine and N,N-dimethyltryptamine (DMT) models of psychosis.
Jörg Putzke; Mariarosa G Spina; Jochen Büchler; Karl-Artur Kovar; Gerald Wolf; Karl-Heinz Smalla
The effects of p-chloroamphetamine, methamphetamine and 3,4-methylenedioxymethamphetamine (ecstasy) on the gene expression of cytoskeletal proteins in the rat brain.
Marianne Patt; Christoph Solbach; Ullrich Wüllner; A Blocher; Anke Stahlschmidt; Daniela Gündisch; Karl-Artur Kovar; Hans-Jürgen Machulla
Synthetic approaches and bio-distribution studies of [11C]methyl-phenidate.

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2007: Karsten Heekeren; Anna Neukirch; Joerg Daumann; Martina Stoll; Maja Obradovic; Karl-Artur Kovar; Mark A Geyer; Euphrosyne Gouzoulis-Mayfrank
Prepulse inhibition of the startle reflex and its attentional modulation in the human S-ketamine and N,N-dimethyltryptamine (DMT) models of psychosis.
Journal of psychopharmacology (Oxford, England) 2007;21(3):312-20.
2007: Jörg Putzke; Mariarosa G Spina; Jochen Büchler; Karl-Artur Kovar; Gerald Wolf; Karl-Heinz Smalla
The effects of p-chloroamphetamine, methamphetamine and 3,4-methylenedioxymethamphetamine (ecstasy) on the gene expression of cytoskeletal proteins in the rat brain.
Addiction biology 2007;12(1):69-80.
2007: Marianne Patt; Christoph Solbach; Ullrich Wüllner; A Blocher; Anke Stahlschmidt; Daniela Gündisch; Karl-Artur Kovar; Hans-Jürgen Machulla
Synthetic approaches and bio-distribution studies of [11C]methyl-phenidate.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Société canadienne des sciences pharmaceutiques 2007;10(2):312s-320s.
2006: Euphrosyne Gouzoulis-Mayfrank; Karsten Heekeren; Anna Neukirch; Martina Stoll; Carsten Stock; Joerg Daumann; Maja Obradovic; Karl-Artur Kovar
Inhibition of return in the human 5HT2A agonist and NMDA antagonist model of psychosis.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2006;31(2):431-41.
2005: Euphrosyne Gouzoulis-Mayfrank; Karsten Heekeren; Anna Neukirch; Martina Stoll; C Stock; Maja Obradovic; Karl-Artur Kovar
Psychological effects of (S)-ketamine and N,N-dimethyltryptamine (DMT): a double-blind, cross-over study in healthy volunteers.
Pharmacopsychiatry 2005;38(6):301-11.
2005: Volker Herzig; Eleonora M I Capuani; Karl-Artur Kovar; Werner J Schmidt
Effects of MPEP on expression of food-, MDMA- or amphetamine-conditioned place preference in rats.
Addiction biology 2005;10(3):243-9.
2005: Heike B Lebsanft; Karl-Artur Kovar; Werner J Schmidt
3,4-Methylenedioxymethamphetamine and naloxone in rat rotational behaviour and open field.
European journal of pharmacology 2005;516(1):34-9.
2005: Heike B Lebsanft; Timo Kohles; Karl-Artur Kovar; Werner J Schmidt
3,4-Methylenedioxymethamphetamine counteracts akinesia enantioselectively in rat rotational behavior and catalepsy.
Synapse (New York, N.Y.) 2005;55(3):148-55.
2005: Joachim Quintus; Karl-Artur Kovar; Peter Link; Harald Hamacher
Urinary excretion of arbutin metabolites after oral administration of bearberry leaf extracts.
Planta medica 2005;71(2):147-52.
2004: M Gaub; Ch Roeseler; Gudrun Roos; Karl-Artur Kovar
Analysis of plant extracts by NIRS: simultaneous determination of kavapyrones and water in dry extracts of Piper methysticum Forst.
Journal of pharmaceutical and biomedical analysis 2004;36(4):859-64.
2004: M Gaub; Alexander von Brocke; Gudrun Roos; Karl-Artur Kovar
High-performance liquid chromatography-coordination ion spray-mass spectrometry (HPLC-CIS/MS): a new tool for the analysis of non-polar compound classes in plant extracts using the example of Piper methysticum Forst.
Phytochemical analysis : PCA 2004;15(5):300-5.
2004: Kim Wuthold; Ines Germann; Gudrun Roos; Olaf Kelber; Dieter Weiser; Helmut Heinle; Karl-Artur Kovar
Thin-layer chromatography and multivariate data analysis of willow bark extracts.
Journal of chromatographic science 2004;42(6):306-9.
2004: Sandra Trkulja; Karl-Artur Kovar
Definite peak identification of (R)-and (S)-methadone and (R)- and (S)-EDDP using established HPLC and CE methods.
Journal of separation science 2004;27(7-8):557-9.
2003: Jochen Buechler; Matthias Schwab; Gerd Mikus; Beate Fischer; Leopold Hermle; Claudia Marx; Georg Grön; Manfred Spitzer; Karl-Artur Kovar
Enantioselective quantitation of the ecstasy compound (R)- and (S)-N-ethyl-3,4-methylenedioxyamphetamine and its major metabolites in human plasma and urine.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2003;793(2):207-22.
2003: Ralph Carsten Schneider; Karl-Artur Kovar
Analysis of ecstasy tablets: comparison of reflectance and transmittance near infrared spectroscopy.
Forensic science international 2003;134(2-3):187-95.
2003: Heike B Lebsanft; Andreas Mayerhofer; Karl-Artur Kovar; Werner J Schmidt
Is the Ecstasy-induced ipsilateral rotation in 6-hydroxydopamine unilaterally lesioned rats dopamine independent?
Journal of neural transmission (Vienna, Austria : 1996) 2003;110(7):707-18.
2003: Antje Harms; Ernst Ulmer; Karl-Artur Kovar
Synthesis and 5-HT2A radioligand receptor binding assays of DOMCl and DOMOM, two novel 5-HT2A receptor ligands.
Archiv der Pharmazie 2003;336(3):155-8.
2002: Anja Meyer; Andreas Mayerhofer; Karl-Artur Kovar; Werner J Schmidt
Rewarding effects of the optical isomers of 3,4-methylenedioxy-methylamphetamine ('Ecstasy') and 3,4-methylenedioxy-ethylamphetamine ('Eve') measured by conditioned place preference in rats.
Neuroscience letters 2002;330(3):280-4.
2002: Werner J Schmidt; Andreas Mayerhofer; Anja Meyer; Karl-Artur Kovar
Ecstasy counteracts catalepsy in rats, an anti-parkinsonian effect?
Neuroscience letters 2002;330(3):251-4.
2002: Anja Meyer; Andreas Mayerhofer; Karl-Artur Kovar; Werner J Schmidt
Enantioselective metabolism of the designer drugs 3,4-methylenedioxymethamphetamine ('ecstasy') and 3,4-methylenedioxyethylamphetamine ('eve') isomers in rat brain and blood.
Neuroscience letters 2002;330(2):193-7.
2002: Julia Wellsow; Karl-Artur Kovar; Hans-Jürgen Machulla
Molecular modeling of potential new and selective PET radiotracers for the serotonin transporter. Positron Emission Tomography.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Société canadienne des sciences pharmaceutiques 2002;5(3):245-57.
2002: I Rager; Gudrun Roos; Peter C Schmidt; Karl-Artur Kovar
Rapid quantification of constituents in St. John's wort extracts by NIR spectroscopy.
Journal of pharmaceutical and biomedical analysis 2002;28(3-4):439-46.
2002: Euphrosyne Gouzoulis-Mayfrank; Bernhard Thelen; S Maier; Karsten Heekeren; Karl-Artur Kovar; Henning Sass; Manfred Spitzer
Effects of the hallucinogen psilocybin on covert orienting of visual attention in humans.
Neuropsychobiology 2002;45(4):205-12.
2001: Andreas Mayerhofer; Karl-Artur Kovar; Werner J Schmidt
Changes in serotonin, dopamine and noradrenaline levels in striatum and nucleus accumbens after repeated administration of the abused drug MDMA in rats.
Neuroscience letters 2001;308(2):99-102.
2001: Manfred Spitzer; B Franke; H Walter; J Buechler; Arthur P Wunderlich; Matthias Schwab; Karl-Artur Kovar; Leopold Hermle; Georg Grön
Enantio-selective cognitive and brain activation effects of N-ethyl-3,4-methylenedioxyamphetamine in humans.
Neuropharmacology 2001;41(2):263-71.
2001: S Essig; Karl-Artur Kovar
Quantitative determination of phospholipids in a pharmaceutical drug by scanning and video densitometry.
Journal of AOAC International 2001;84(4):1283-6.
2001: M Brunnenberg; Karl-Artur Kovar
Stereospecific analysis of ecstasy-like N-ethyl-3,4-methylenedioxyamphetamine and its metabolites in humans.
Journal of chromatography. B, Biomedical sciences and applications 2001;751(1):9-18.
2001: S Stahlmann; T Herkert; C Röseler; I Rager; Karl-Artur Kovar
New sorbent for HPTLC--FTIR in situ determination of impurities in flurazepam.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2001;12(4):461-9.
2001: T Herkert; H Prinz; Karl-Artur Kovar
One hundred percent online identity check of pharmaceutical products by near-infrared spectroscopy on the packaging line.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2001;51(1):9-16.
2000: Mariarosa G Spina; G Grecksch; Karl-Artur Kovar; Gerald Wolf; Jörg Putzke
Microtubule-associated protein 2 (MAP2) and c-fos expression in the rat prefrontal cortex following subchronic treatment with substituted amphetamines.
Annals of the New York Academy of Sciences 2000;914():65-70.
2000: A Harms; Daniela Gündisch; C E Müller; Karl-Artur Kovar
Development of a 5-hydroxytryptamine(2A) receptor binding assay for high throughput screening using 96-well microfilter plates.
Journal of biomolecular screening 2000;5(4):269-78.
2000: Jan Seyfried; Bernd Evert; C Rundfeldt; Jörg B Schulz; Karl-Artur Kovar; Thomas Klockgether; Ullrich Wüllner
Flupirtine and retigabine prevent L-glutamate toxicity in rat pheochromocytoma PC 12 cells.
European journal of pharmacology 2000;400(2-3):155-66.
2000: K Kreth; Karl-Artur Kovar; Matthias Schwab; Uli Zanger
Identification of the human cytochromes P450 involved in the oxidative metabolism of "Ecstasy"-related designer drugs.
Biochemical pharmacology 2000;59(12):1563-71.
2000: Jan Seyfried; F Soldner; Wolfram S Kunz; Jörg B Schulz; Thomas Klockgether; Karl-Artur Kovar; Ullrich Wüllner
Effect of 1-methyl-4-phenylpyridinium on glutathione in rat pheochromocytoma PC 12 cells.
Neurochemistry international 2000;36(6):489-97.
1999: N Sondermann; Karl-Artur Kovar
Screening experiments of ecstasy street samples using near infrared spectroscopy.
Forensic science international 1999;106(3):147-56.
1999: Euphrosyne Gouzoulis-Mayfrank; Leopold Hermle; Karl-Artur Kovar; Henning Sass
[Comment on R. Thomasius, M. Schmolke, D. Kraus: MDMA ("Ecstasy") use--an overview of psychiatric and medical sequelae].
Fortschritte der Neurologie-Psychiatrie 1999;67(12):574-6.
1999: E Krämer; Karl-Artur Kovar
On-line coupling of automated solid-phase extraction with high-performance liquid chromatography and electrochemical detection. Quantitation of oxidizable drugs of abuse and their metabolites in plasma and urine.
Journal of chromatography. B, Biomedical sciences and applications 1999;731(2):167-77.
1999: Euphrosyne Gouzoulis-Mayfrank; Mathias Schreckenberger; Osama Sabri; Christian Arning; Bernhard Thelen; Manfred Spitzer; Karl-Artur Kovar; Leopold Hermle; Udalrich Büll; Henning Sass
Neurometabolic effects of psilocybin, 3,4-methylenedioxyethylamphetamine (MDE) and d-methamphetamine in healthy volunteers. A double-blind, placebo-controlled PET study with [18F]FDG.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1999;20(6):565-81.
1999: Jan Seyfried; F Soldner; Jörg B Schulz; Thomas Klockgether; Karl-Artur Kovar; Ullrich Wüllner
Differential effects of L-buthionine sulfoximine and ethacrynic acid on glutathione levels and mitochondrial function in PC12 cells.
Neuroscience letters 1999;264(1-3):1-4.
1999: Euphrosyne Gouzoulis-Mayfrank; Bernhard Thelen; Elmar Habermeyer; Hanns Jürgen Kunert; Karl-Artur Kovar; H Lindenblatt; Leopold Hermle; Manfred Spitzer; Henning Sass
Psychopathological, neuroendocrine and autonomic effects of 3,4-methylenedioxyethylamphetamine (MDE), psilocybin and d-methamphetamine in healthy volunteers. Results of an experimental double-blind placebo-controlled study.
Psychopharmacology 1999;142(1):41-50.
1998: M Brunnenberg; H Lindenblatt; Euphrosyne Gouzoulis-Mayfrank; Karl-Artur Kovar
Quantitation of N-ethyl-3,4-methylenedioxyamphetamine and its major metabolites in human plasma by high-performance liquid chromatography and fluorescence detection.
Journal of chromatography. B, Biomedical sciences and applications 1998;719(1-2):79-85.
1998: Euphrosyne Gouzoulis-Mayfrank; Karsten Heekeren; Bernhard Thelen; H Lindenblatt; Karl-Artur Kovar; Henning Sass; Mark A Geyer
Effects of the hallucinogen psilocybin on habituation and prepulse inhibition of the startle reflex in humans.
Behavioural pharmacology 1998;9(7):561-6.
1998: Karl-Artur Kovar
Chemistry and pharmacology of hallucinogens, entactogens and stimulants.
Pharmacopsychiatry 1998;31 Suppl 2():69-72.
1998: P Merckle; Karl-Artur Kovar
Assay of effervescent tablets by near-infrared spectroscopy in transmittance and reflectance mode: acetylsalicylic acid in mono and combination formulations.
Journal of pharmaceutical and biomedical analysis 1998;17(3):365-74.
1998: H Lindenblatt; E Krämer; P Holzmann-Erens; Euphrosyne Gouzoulis-Mayfrank; Karl-Artur Kovar
Quantitation of psilocin in human plasma by high-performance liquid chromatography and electrochemical detection: comparison of liquid-liquid extraction with automated on-line solid-phase extraction.
Journal of chromatography. B, Biomedical sciences and applications 1998;709(2):255-63.
1997: S Schmetzer; P Greenidge; Karl-Artur Kovar; M Schulze-Alexandru; G Folkers
Structure-activity relationships of cannabinoids: a joint CoMFA and pseudoreceptor modelling study.
Journal of computer-aided molecular design 1997;11(3):278-92.
1997: W Pisternick; Karl-Artur Kovar; H Ensslin
High-performance thin-layer chromatographic determination of N-ethyl-3,4-methylenedioxyamphetamine and its major metabolites in urine and comparison with high-performance liquid chromatography.
Journal of chromatography. B, Biomedical sciences and applications 1997;688(1):63-9.
1996: H K Ensslin; Karl-Artur Kovar; H H Maurer
Toxicological detection of the designer drug 3,4-methylenedioxyethylamphetamine (MDE, "Eve") and its metabolites in urine by gas chromatography-mass spectrometry and fluorescence polarization immunoassay.
Journal of chromatography. B, Biomedical applications 1996;683(2):189-97.
1996: H K Ensslin; H H Maurer; E Gouzoulis; Leopold Hermle; Karl-Artur Kovar
Metabolism of racemic 3,4-methylenedioxyethylamphetamine in humans. Isolation, identification, quantification, and synthesis of urinary metabolites.
Drug metabolism and disposition: the biological fate of chemicals 1996;24(8):813-20.
1996: M Spitzer; M Thimm; Leopold Hermle; P Holzmann; Karl-Artur Kovar; H Heimann; Euphrosyne Gouzoulis-Mayfrank; U Kischka; F Schneider
Increased activation of indirect semantic associations under psilocybin.
Biological psychiatry 1996;39(12):1055-7.
1996: Euphrosyne Gouzoulis-Mayfrank; Leopold Hermle; Karl-Artur Kovar; Henning Sass
[Entactogenic drugs "ecstasy" (MDMA), "eve" (MDE) and other ring-substituted methamphetamine derivatives. A new class of substances among illegal designer drugs?].
Der Nervenarzt 1996;67(5):369-80.
1994: A Rupp; Karl-Artur Kovar; G Beuerle; C Ruf; Gerd Folkers
A new pharmophoric model for 5-HT reuptake-inhibitors: differentiation of amphetamine analogues.
Pharmaceutica acta Helvetiae 1994;68(4):235-44.
1993: Leopold Hermle; E Gouzoulis; G Oepen; M Spitzer; Karl-Artur Kovar; D Borchardt; M Fünfgeld; M Berger
[Significance of historical and current hallucinogenic research in psychiatry].
Der Nervenarzt 1993;64(9):562-71.
1993: E Gouzoulis; U von Bardeleben; A Rupp; Karl-Artur Kovar; Leopold Hermle
Neuroendocrine and cardiovascular effects of MDE in healthy volunteers.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1993;8(3):187-93.
1993: Leopold Hermle; M Spitzer; D Borchardt; Karl-Artur Kovar; E Gouzoulis
Psychological effects of MDE in normal subjects. Are entactogens a new class of psychoactive agents?
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1993;8(2):171-6.
1992: Peter Maisenbacher; Karl-Artur Kovar
Analysis and stability of Hyperici oleum.
Planta medica 1992;58(4):351-4.
1990: C Rösch; Karl-Artur Kovar
[Synthetic drugs of abuse of the second generation (so-called designer drugs). 2. Analysis of arylalkylamines (amphetamine)].
Pharmazie in unserer Zeit 1990;19(5):211-21.
1990: Karl-Artur Kovar; C Rösch; A Rupp; Leopold Hermle
[Synthetic drugs of abuse, the second generation (designer drugs). 1. Amphetamine and other arylalkane amines].
Pharmazie in unserer Zeit 1990;19(3):99-107.
1990: Karl-Artur Kovar; M N el Bolkiny; R Rink; M A Hamid
An enzymatic assay for the colorimetric and fluorimetric determination of uric acid in sera.
Archiv der Pharmazie 1990;323(4):235-7.