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Timothy Koves

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C Lawrence Kien; Timothy R Koves; Connie L Tompkins; Janice Y Bunn; Karen I Crain; Julie A Dumas; David B Ebenstein; Deborah M Muoio
Substituting dietary monounsaturated fat for saturated fat is associated with increased daily physical activity and resting energy expenditure and with changes in mood.
C Lawrence Kien; Timothy R Koves; Matthew E Poynter; Robert Stevens; James Bain; Janice Y Bunn; Catherine M Champagne; Karen I Crain; Naomi K Fukagawa; Olga Ikayeva; Deborah M Muoio
A lipidomics analysis of the relationship between dietary fatty acid composition and insulin sensitivity in young adults.
Kathryn C Jackson; Timothy R Koves; Richard M Lovering; Amy C Maher; Deborah M Muoio; Rosemary A Schuh; Arend Bonen; Olga Ilkayeva; David M Thomson; Lindsay M Wohlers; Espen E Spangenburg
Ectopic lipid deposition and the metabolic profile of skeletal muscle in ovariectomized mice.

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All Publications

2013: C Lawrence Kien; Timothy R Koves; Connie L Tompkins; Janice Y Bunn; Karen I Crain; Julie A Dumas; David B Ebenstein; Deborah M Muoio
Substituting dietary monounsaturated fat for saturated fat is associated with increased daily physical activity and resting energy expenditure and with changes in mood.
The American journal of clinical nutrition 2013;97(4):689-97.
2013: C Lawrence Kien; Timothy R Koves; Matthew E Poynter; Robert Stevens; James Bain; Janice Y Bunn; Catherine M Champagne; Karen I Crain; Naomi K Fukagawa; Olga Ikayeva; Deborah M Muoio
A lipidomics analysis of the relationship between dietary fatty acid composition and insulin sensitivity in young adults.
Diabetes 2013;62(4):1054-63.
2013: Kathryn C Jackson; Timothy R Koves; Richard M Lovering; Amy C Maher; Deborah M Muoio; Rosemary A Schuh; Arend Bonen; Olga Ilkayeva; David M Thomson; Lindsay M Wohlers; Espen E Spangenburg
Ectopic lipid deposition and the metabolic profile of skeletal muscle in ovariectomized mice.
American journal of physiology. Regulatory, integrative and comparative physiology 2013;304(3):R206-17.
2013: Timothy R Koves; Ruth C Meex; Merrie Mosedale; Ramamani Arumugam; Karen L DeBalsi; Karen Everingham; Matthijs K C Hesselink; C Lawrence Kien; J P Kovalik; Esther Phielix; Patrick Schrauwen; Lauren M Sparks; Leigh Thorne; Deborah M Muoio
PPARγ coactivator-1α contributes to exercise-induced regulation of intramuscular lipid droplet programming in mice and humans.
Journal of lipid research 2013;54(2):522-34.
2012: Brennan K Smith; Jeffrey C Smith; David C Wright; Timothy R Koves; Deborah M Muoio; P Darrell Neufer; Christopher G R Perry; Graham P Holloway
Identification of a novel malonyl-CoA IC(50) for CPT-I: implications for predicting in vivo fatty acid oxidation rates.
The Biochemical journal 2012;448(1):13-20.
2012: Deborah M Muoio; Robert C Noland; Eric Ravussin; Sarah E Seiler; Robert D Stevens; Jingying Zhang; Sudip Bajpeyi; Jeffrey D Covington; Michael N Davies; Karen L DeBalsi; Olga Ilkayeva; Indu Kheterpal; Jean-Paul Kovalik; Timothy R Koves; William Kraus; Randall L Mynatt
Muscle-specific deletion of carnitine acetyltransferase compromises glucose tolerance and metabolic flexibility.
Cell metabolism 2012;15(5):764-77.
2011: Diego A Miranda; Deborah M Muoio; Gary J Schwartz; Hadi Al-Hasani; Alexandra Chadt; Gary W Cline; David A Gross; Timothy R Koves; David L Silver
Re-patterning of skeletal muscle energy metabolism by fat storage-inducing transmembrane protein 2.
The Journal of biological chemistry 2011;286(49):42188-99.
2010: John R Ussher; Timothy R Koves; Virgilio J J Cadete; Liyan Zhang; Jagdip S Jaswal; Suzanne J Swyrd; David G Lopaschuk; Spencer D Proctor; Wendy Keung; Deborah M Muoio; Gary D Lopaschuk
Inhibition of de novo ceramide synthesis reverses diet-induced insulin resistance and enhances whole-body oxygen consumption.
Diabetes 2010;59(10):2453-64.
2010: John P Thyfault; Melanie G Cree; Edward B Tapscott; Jill A Bell; Timothy R Koves; Olga Ilkayeva; Robert R Wolfe; G Lynis Dohm; Deborah M Muoio
Metabolic profiling of muscle contraction in lean compared with obese rodents.
American journal of physiology. Regulatory, integrative and comparative physiology 2010;299(3):R926-34.
2009: John R Ussher; Timothy R Koves; Jagdip S Jaswal; Liyan Zhang; Olga Ilkayeva; Jason R B Dyck; Deborah M Muoio; Gary D Lopaschuk
Insulin-stimulated cardiac glucose oxidation is increased in high-fat diet-induced obese mice lacking malonyl CoA decarboxylase.
Diabetes 2009;58(8):1766-75.
2009: Liza Hayes; Robert C Noland; Timothy R Koves; Weibing Xing; Olga Ilkayeva; Michael J Muehlbauer; Robert D Stevens; Deborah M Muoio
Metabolic profiling of PPARalpha-/- mice reveals defects in carnitine and amino acid homeostasis that are partially reversed by oral carnitine supplementation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(2):586-604.
2008: Timothy R Koves; John R Ussher; Robert C Noland; Dorothy H Slentz; Merrie Mosedale; Olga Ilkayeva; James R Bain; Robert Stevens; Jason R B Dyck; Christopher B Newgard; Gary D Lopaschuk; Deborah M Muoio
Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance.
Cell metabolism 2008;7(1):45-56.
2007: Deborah M Muoio; Timothy R Koves
Skeletal muscle adaptation to fatty acid depends on coordinated actions of the PPARs and PGC1 alpha: implications for metabolic disease.
Applied physiology, nutrition, and metabolism = Physiologie appliquée, nutrition et métabolisme 2007;32(5):874-83.
2007: John P Thyfault; Melanie G Cree; Donghai Zheng; Jennifer J Zwetsloot; Edward B Tapscott; Timothy R Koves; Olga Ilkayeva; Robert R Wolfe; Deborah M Muoio; G Lynis Dohm
Contraction of insulin-resistant muscle normalizes insulin action in association with increased mitochondrial activity and fatty acid catabolism.
American journal of physiology. Cell physiology 2007;292(2):C729-39.
2007: Deborah M Muoio; Timothy R Koves
Lipid-induced metabolic dysfunction in skeletal muscle.
Novartis Foundation symposium 2007;286():24-38; discussion 38-46, 162-3, 196-203.
2006: Stéphanie Gaillard; Linda L Grasfeder; Christiane L Haeffele; Edward K Lobenhofer; Tzu-Ming Chu; Russell D Wolfinger; Dmitri Kazmin; Timothy R Koves; Deborah M Muoio; Ching-yi Chang; Donald P McDonnell
Receptor-selective coactivators as tools to define the biology of specific receptor-coactivator pairs.
Molecular cell 2006;24(5):797-803.
2005: Timothy R Koves; Ping Li; Jie An; Takayuki Akimoto; Dorothy H Slentz; Olga Ilkayeva; G Lynis Dohm; Zhen Yan; Christopher B Newgard; Deborah M Muoio
Peroxisome proliferator-activated receptor-gamma co-activator 1alpha-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced mitochondrial inefficiency.
The Journal of biological chemistry 2005;280(39):33588-98.
2005: Timothy R Koves; Robert C Noland; Andrew L Bates; Sarah T Henes; Deborah M Muoio; Ronald N Cortright
Subsarcolemmal and intermyofibrillar mitochondria play distinct roles in regulating skeletal muscle fatty acid metabolism.
American journal of physiology. Cell physiology 2005;288(5):C1074-82.
2005: Jason R Berggren; Charles J Tanner; Timothy R Koves; Deborah M Muoio; Joseph A Houmard
Glucose uptake in muscle cell cultures from endurance-trained men.
Medicine and science in sports and exercise 2005;37(4):579-84.
2004: James D Fluckey; Ronald N Cortright; Edward B Tapscott; Timothy R Koves; Latasha Smith; Steven C Pohnert; G Lynis Dohm
Active involvement of PKC for insulin-mediated rates of muscle protein synthesis in Zucker rats.
American journal of physiology. Endocrinology and metabolism 2004;286(5):E753-8.
2004: Jie An; Deborah M Muoio; Masakazu Shiota; Yuka Fujimoto; Gary W Cline; Gerald I Shulman; Timothy R Koves; Robert Stevens; David S Millington; Christopher B Newgard
Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance.
Nature medicine 2004;10(3):268-74.
2004: Glen M Sizemore; Conchita Co; Timothy R Koves; Thomas J Martin; James E Smith
Time-dependent recovery from the effects of 6-hydroxydopamine lesions of the rat nucleus accumbens on cocaine self-administration and the levels of dopamine in microdialysates.
Psychopharmacology 2004;171(4):413-20.
2003: James E Smith; Timothy R Koves; Conchita Co
Brain neurotransmitter turnover rates during rat intravenous cocaine self-administration.
Neuroscience 2003;117(2):461-75.
2002: Jong-Yeon Kim; Timothy R Koves; Geng-Sheng Yu; Tod Gulick; Ronald N Cortright; G Lynis Dohm; Deborah M Muoio
Evidence of a malonyl-CoA-insensitive carnitine palmitoyltransferase I activity in red skeletal muscle.
American journal of physiology. Endocrinology and metabolism 2002;282(5):E1014-22.
2002: Charles J Tanner; Timothy R Koves; Ronald L Cortright; Walter J Pories; Young-Bum Kim; Barbara B Kahn; G Lynis Dohm; Joseph A Houmard
Effect of short-term exercise training on insulin-stimulated PI 3-kinase activity in middle-aged men.
American journal of physiology. Endocrinology and metabolism 2002;282(1):E147-53.
2001: Robert C Hickner; P M Mehta; D Dyck; Paul DeVita; Joseph A Houmard; Timothy R Koves; P Byrd
Relationship between fat-to-fat-free mass ratio and decrements in leg strength after downhill running.
Journal of applied physiology (Bethesda, Md. : 1985) 2001;90(4):1334-41.
2000: M J Berry; Timothy R Koves; J J Benedetto
The influence of speed, grade and mass during simulated off road bicycling.
Applied ergonomics 2000;31(5):531-6.
2000: Ronald N Cortright; Timothy R Koves
Sex differences in substrate metabolism and energy homeostasis.
Canadian journal of applied physiology = Revue canadienne de physiologie appliquée 2000;25(4):288-311.
2000: Joseph A Houmard; ML Weidner; Timothy R Koves; Robert C Hickner; Ronald L Cortright
Association between muscle fiber composition and blood pressure levels during exercise in men.
American journal of hypertension 2000;13(6 Pt 1):586-92.
1997: Scott Hemby; Conchita Co; Timothy R Koves; James E Smith; SI Dworkin
Differences in extracellular dopamine concentrations in the nucleus accumbens during response-dependent and response-independent cocaine administration in the rat.
Psychopharmacology 1997;133(1):7-16.