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Stephen Kowalczykowski

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
11
Mazin, Alexander
10
Sugiyama, Tomohiko
9
Baskin, Ronald
8
Dillingham, Mark
7
Bianco, Piero
7
Anderson, DG
6
Amitani, Ichiro
6
Handa, Naofumi
6
Harmon, Frank
6
Seitz, Erica
6
Dixon, Dan A.
6
Roman, Linda
5
Zaitsev, EN
5
Spies, Maria
5
Chédin, Frédéric

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Publications

TOP 3
Carreira Aura; Kowalczykowski Stephen C
BRCA2: Shining light on the regulation of DNA-binding selectivity by RAD51.
Handa Naofumi; Amitani Ichiro; Gumlaw Nathan; Sandler Steven J; Kowalczykowski Stephen C
Single molecule analysis of a red fluorescent RecA protein reveals a defect in nucleoprotein filament nucleation that relates to its reduced biological functions.
Nimonkar Amitabh V; Kowalczykowski Stephen C
Second-end DNA capture in double-strand break repair: how to catch a DNA by its tail.

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All Publications

2009: Carreira Aura; Kowalczykowski Stephen C
BRCA2: Shining light on the regulation of DNA-binding selectivity by RAD51.
Cell cycle (Georgetown, Tex.) 2009;8(21):3445-7.
2009: Handa Naofumi; Amitani Ichiro; Gumlaw Nathan; Sandler Steven J; Kowalczykowski Stephen C
Single molecule analysis of a red fluorescent RecA protein reveals a defect in nucleoprotein filament nucleation that relates to its reduced biological functions.
The Journal of biological chemistry 2009;284(28):18664-73.
2009: Nimonkar Amitabh V; Kowalczykowski Stephen C
Second-end DNA capture in double-strand break repair: how to catch a DNA by its tail.
Cell cycle (Georgetown, Tex.) 2009;8(12):1816-7.
2009: Handa Naofumi; Morimatsu Katsumi; Lovett Susan T; Kowalczykowski Stephen C
Reconstitution of initial steps of dsDNA break repair by the RecF pathway of E. coli.
Genes & development 2009;23(10):1234-45.
2009: Haseltine Cynthia A; Kowalczykowski Stephen C
An archaeal Rad54 protein remodels DNA and stimulates DNA strand exchange by RadA.
Nucleic acids research 2009;37(8):2757-70.
2009: Carreira Aura; Hilario Jovencio; Amitani Ichiro; Baskin Ronald J; Shivji Mahmud K K; Venkitaraman Ashok R; Kowalczykowski Stephen C
The BRC repeats of BRCA2 modulate the DNA-binding selectivity of RAD51.
Cell 2009;136(6):1032-43.
2009: Nimonkar Amitabh V; Sica R Alejandro; Kowalczykowski Stephen C
Rad52 promotes second-end DNA capture in double-stranded break repair to form complement-stabilized joint molecules.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(9):3077-82.
2009: Hilario Jovencio; Amitani Ichiro; Baskin Ronald J; Kowalczykowski Stephen C
Direct imaging of human Rad51 nucleoprotein dynamics on individual DNA molecules.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(2):361-8.
2008: Dillingham Mark S; Kowalczykowski Stephen C
RecBCD enzyme and the repair of double-stranded DNA breaks.
Microbiology and molecular biology reviews : MMBR 2008;72(4):642-71, Table of Contents.
2008: Nimonkar Amitabh V; Ozsoy A Zeynep; Genschel Jochen; Modrich Paul; Kowalczykowski Stephen C
Human exonuclease 1 and BLM helicase interact to resect DNA and initiate DNA repair.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(44):16906-11.
2008: Dillingham Mark S; Tibbles Katherine L; Hunter Jackie L; Bell Jason C; Kowalczykowski Stephen C; Webb Martin R
Fluorescent single-stranded DNA binding protein as a probe for sensitive, real-time assays of helicase activity.
Biophysical journal 2008;95(7):3330-9.
2008: Kowalczykowski Stephen C
Structural biology: snapshots of DNA repair.
Nature 2008;453(7194):463-6.
2008: Wu Yun; Kantake Noriko; Sugiyama Tomohiko; Kowalczykowski Stephen C
Rad51 protein controls Rad52-mediated DNA annealing.
The Journal of biological chemistry 2008;283(21):14883-92.
2007: Spies Maria; Amitani Ichiro; Baskin Ronald J; Kowalczykowski Stephen C
RecBCD enzyme switches lead motor subunits in response to chi recognition.
Cell 2007;131(4):694-705.
2007: Nimonkar Amitabh V; Amitani Ichiro; Baskin Ronald J; Kowalczykowski Stephen C
Single molecule imaging of Tid1/Rdh54, a Rad54 homolog that translocates on duplex DNA and can disrupt joint molecules.
The Journal of biological chemistry 2007;282(42):30776-84.
2007: Galletto Roberto; Kowalczykowski Stephen C
RecA.
Current biology : CB 2007;17(11):R395-7.
2007: Handa Naofumi; Kowalczykowski Stephen C
A RecA mutant, RecA(730), suppresses the recombination deficiency of the RecBC(1004)D-chi* interaction in vitro and in vivo.
Journal of molecular biology 2007;365(5):1314-25.
2006: Wu Yun; Siino Joseph S; Sugiyama Tomohiko; Kowalczykowski Stephen C
The DNA binding preference of RAD52 and RAD59 proteins: implications for RAD52 and RAD59 protein function in homologous recombination.
The Journal of biological chemistry 2006;281(52):40001-9.
2006: Sugiyama Tomohiko; Kantake Noriko; Wu Yun; Kowalczykowski Stephen C
Rad52-mediated DNA annealing after Rad51-mediated DNA strand exchange promotes second ssDNA capture.
The EMBO journal 2006;25(23):5539-48.
2006: Galletto Roberto; Amitani Ichiro; Baskin Ronald J; Kowalczykowski Stephen C
Direct observation of individual RecA filaments assembling on single DNA molecules.
Nature 2006;443(7113):875-8.
2006: Amitani Ichiro; Baskin Ronald J; Kowalczykowski Stephen C
Visualization of Rad54, a chromatin remodeling protein, translocating on single DNA molecules.
Molecular cell 2006;23(1):143-8.
2006: Chédin Frédéric; Handa Naofumi; Dillingham Mark S; Kowalczykowski Stephen C
The AddAB helicase/nuclease forms a stable complex with its cognate chi sequence during translocation.
The Journal of biological chemistry 2006;281(27):18610-7.
2006: Wu Yun; Sugiyama Tomohiko; Kowalczykowski Stephen C
DNA annealing mediated by Rad52 and Rad59 proteins.
The Journal of biological chemistry 2006;281(22):15441-9.
2006: Spies Maria; Kowalczykowski Stephen C
The RecA binding locus of RecBCD is a general domain for recruitment of DNA strand exchange proteins.
Molecular cell 2006;21(4):573-80.
2006: Seitz Erica M; Kowalczykowski Stephen C
Human Rad51 protein displays enhanced homologous pairing of DNA sequences resembling those at genetically unstable loci.
Nucleic acids research 2006;34(10):2847-52.
2005: Dillingham Mark S; Webb Martin R; Kowalczykowski Stephen C
Bipolar DNA translocation contributes to highly processive DNA unwinding by RecBCD enzyme.
The Journal of biological chemistry 2005;280(44):37069-77.
2005: Spies Maria; Dillingham Mark S; Kowalczykowski Stephen C
Translocation by the RecB motor is an absolute requirement for {chi}-recognition and RecA protein loading by RecBCD enzyme.
The Journal of biological chemistry 2005;280(44):37078-87.
2005: Thomä Nicolas H; Czyzewski Bryan K; Alexeev Andrei A; Mazin Alexander V; Kowalczykowski Stephen C; Pavletich Nikola P
Structure of the SWI2/SNF2 chromatin-remodeling domain of eukaryotic Rad54.
Nature structural & molecular biology 2005;12(4):350-6.
2005: Handa Naofumi; Bianco Piero R; Baskin Ronald J; Kowalczykowski Stephen C
Direct visualization of RecBCD movement reveals cotranslocation of the RecD motor after chi recognition.
Molecular cell 2005;17(5):745-50.
2005: Kowalczykowski Stephen C
Cancer: catalyst of a catalyst.
Nature 2005;433(7026):591-2.
2004: Singleton Martin R; Dillingham Mark S; Gaudier Martin; Kowalczykowski Stephen C; Wigley Dale B
Crystal structure of RecBCD enzyme reveals a machine for processing DNA breaks.
Nature 2004;432(7014):187-93.
2004: Mazina Olga M; Mazin Alexander V; Nakagawa Takuro; Kolodner Richard D; Kowalczykowski Stephen C
Saccharomyces cerevisiae Mer3 helicase stimulates 3'-5' heteroduplex extension by Rad51; implications for crossover control in meiotic recombination.
Cell 2004;117(1):47-56.
2003: Harmon Frank G; Brockman Joel P; Kowalczykowski Stephen C
RecQ helicase stimulates both DNA catenation and changes in DNA topology by topoisomerase III.
The Journal of biological chemistry 2003;278(43):42668-78.
2003: Spies Maria; Bianco Piero R; Dillingham Mark S; Handa Naofumi; Baskin Ronald J; Kowalczykowski Stephen C
A molecular throttle: the recombination hotspot chi controls DNA translocation by the RecBCD helicase.
Cell 2003;114(5):647-54.
2003: Dillingham Mark S; Spies Maria; Kowalczykowski Stephen C
RecBCD enzyme is a bipolar DNA helicase.
Nature 2003;423(6942):893-7.
2003: Kantake Noriko; Sugiyama Tomohiko; Kolodner Richard D; Kowalczykowski Stephen C
The recombination-deficient mutant RPA (rfa1-t11) is displaced slowly from single-stranded DNA by Rad51 protein.
The Journal of biological chemistry 2003;278(26):23410-7.
2003: Morimatsu Katsumi; Kowalczykowski Stephen C
RecFOR proteins load RecA protein onto gapped DNA to accelerate DNA strand exchange: a universal step of recombinational repair.
Molecular cell 2003;11(5):1337-47.
2003: Veaute Xavier; Jeusset Josette; Soustelle Christine; Kowalczykowski Stephen C; Le Cam Eric; Fabre Francis
The Srs2 helicase prevents recombination by disrupting Rad51 nucleoprotein filaments.
Nature 2003;423(6937):309-12.
2003: Mirshad Julie K; Kowalczykowski Stephen C
Biochemical characterization of a mutant RecA protein altered in DNA-binding loop 1.
Biochemistry 2003;42(19):5945-54.
2003: Mirshad Julie K; Kowalczykowski Stephen C
Biochemical basis of the constitutive coprotease activity of RecA P67W protein.
Biochemistry 2003;42(19):5937-44.
2003: Mazin Alexander V; Alexeev Andrei A; Kowalczykowski Stephen C
A novel function of Rad54 protein. Stabilization of the Rad51 nucleoprotein filament.
The Journal of biological chemistry 2003;278(16):14029-36.
2003: Alexeev Andrei; Mazin Alexander; Kowalczykowski Stephen C
Rad54 protein possesses chromatin-remodeling activity stimulated by the Rad51-ssDNA nucleoprotein filament.
Nature structural biology 2003;10(3):182-6.
2003: Lio Yi-Ching; Mazin Alexander V; Kowalczykowski Stephen C; Chen David J
Complex formation by the human Rad51B and Rad51C DNA repair proteins and their activities in vitro.
The Journal of biological chemistry 2003;278(4):2469-78.
2003: Stohl Elizabeth A; Brockman Joel P; Burkle Kristin L; Morimatsu Katsumi; Kowalczykowski Stephen C; Seifert H Steven
Escherichia coli RecX inhibits RecA recombinase and coprotease activities in vitro and in vivo.
The Journal of biological chemistry 2003;278(4):2278-85.
2002: Kowalczykowski Stephen C
Molecular mimicry connects BRCA2 to Rad51 and recombinational DNA repair.
Nature structural biology 2002;9(12):897-9.
2002: Kantake Noriko; Madiraju Murty V V M; Sugiyama Tomohiko; Kowalczykowski Stephen C
Escherichia coli RecO protein anneals ssDNA complexed with its cognate ssDNA-binding protein: A common step in genetic recombination.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(24):15327-32.
2002: Sugiyama Tomohiko; Kowalczykowski Stephen C
Rad52 protein associates with replication protein A (RPA)-single-stranded DNA to accelerate Rad51-mediated displacement of RPA and presynaptic complex formation.
The Journal of biological chemistry 2002;277(35):31663-72.
2002: New James H; Kowalczykowski Stephen C
Rad52 protein has a second stimulatory role in DNA strand exchange that complements replication protein-A function.
The Journal of biological chemistry 2002;277(29):26171-6.
2002: Haseltine Cynthia A; Kowalczykowski Stephen C
A distinctive single-strand DNA-binding protein from the Archaeon Sulfolobus solfataricus.
Molecular microbiology 2002;43(6):1505-15.
2002: Chédin Frédéric; Kowalczykowski Stephen C
A novel family of regulated helicases/nucleases from Gram-positive bacteria: insights into the initiation of DNA recombination.
Molecular microbiology 2002;43(4):823-34.
2001: Yang S; Yu X; Seitz E M; Kowalczykowski S C; Egelman E H
Archaeal RadA protein binds DNA as both helical filaments and octameric rings.
Journal of molecular biology 2001;314(5):1077-85.
2001: Dillingham M S; Kowalczykowski S C
A step backward in advancing DNA replication: rescue of stalled replication forks by RecG.
Molecular cell 2001;8(4):734-6.
2001: Solinger J A; Lutz G; Sugiyama T; Kowalczykowski S C; Heyer W D
Rad54 protein stimulates heteroduplex DNA formation in the synaptic phase of DNA strand exchange via specific interactions with the presynaptic Rad51 nucleoprotein filament.
Journal of molecular biology 2001;307(5):1207-21.
2001: Bianco P R; Brewer L R; Corzett M; Balhorn R; Yeh Y; Kowalczykowski S C; Baskin R J
Processive translocation and DNA unwinding by individual RecBCD enzyme molecules.
Nature 2001;409(6818):374-8.
2001: Harmon F G; Kowalczykowski S C
Biochemical characterization of the DNA helicase activity of the escherichia coli RecQ helicase.
The Journal of biological chemistry 2001;276(1):232-43.
2001: Seitz E M; Haseltine C A; Kowalczykowski S C
DNA recombination and repair in the archaea.
Advances in applied microbiology 2001;50():101-69.
2000: Kowalczykowski S C
Some assembly required.
Nature structural biology 2000;7(12):1087-9.
2000: Mazin A V; Bornarth C J; Solinger J A; Heyer W D; Kowalczykowski S C
Rad54 protein is targeted to pairing loci by the Rad51 nucleoprotein filament.
Molecular cell 2000;6(3):583-92.
2000: Seitz E M; Kowalczykowski S C
The DNA binding and pairing preferences of the archaeal RadA protein demonstrate a universal characteristic of DNA strand exchange proteins.
Molecular microbiology 2000;37(3):555-60.
2000: Arnold D A; Handa N; Kobayashi I; Kowalczykowski S C
A novel, 11 nucleotide variant of chi, chi*: one of a class of sequences defining the Escherichia coli recombination hotspot chi.
Journal of molecular biology 2000;300(3):469-79.
2000: Bianco P R; Kowalczykowski S C
Translocation step size and mechanism of the RecBC DNA helicase.
Nature 2000;405(6784):368-72.
2000: Arnold D A; Kowalczykowski S C
Facilitated loading of RecA protein is essential to recombination by RecBCD enzyme.
The Journal of biological chemistry 2000;275(16):12261-5.
2000: Chédin F; Ehrlich S D; Kowalczykowski S C
The Bacillus subtilis AddAB helicase/nuclease is regulated by its cognate Chi sequence in vitro.
Journal of molecular biology 2000;298(1):7-20.
2000: Kowalczykowski S C
Initiation of genetic recombination and recombination-dependent replication.
Trends in biochemical sciences 2000;25(4):156-65.
2000: Zaitsev E N; Kowalczykowski S C
A novel pairing process promoted by Escherichia coli RecA protein: inverse DNA and RNA strand exchange.
Genes & development 2000;14(6):740-9.
2000: Churchill J J; Kowalczykowski S C
Identification of the RecA protein-loading domain of RecBCD enzyme.
Journal of molecular biology 2000;297(3):537-42.
2000: Mazin A V; Zaitseva E; Sung P; Kowalczykowski S C
Tailed duplex DNA is the preferred substrate for Rad51 protein-mediated homologous pairing.
The EMBO journal 2000;19(5):1148-56.
2000: Harmon F G; Kowalczykowski S C
Coupling of DNA helicase function to DNA strand exchange activity.
Methods in molecular biology (Clifton, N.J.) 2000;152():75-89.
1999: Zaitsev E N; Kowalczykowski S C
Enhanced monomer-monomer interactions can suppress the recombination deficiency of the recA142 allele.
Molecular microbiology 1999;34(1):1-9.
1999: Anderson D G; Churchill J J; Kowalczykowski S C
A single mutation, RecB(D1080A,) eliminates RecA protein loading but not Chi recognition by RecBCD enzyme.
The Journal of biological chemistry 1999;274(38):27139-44.
1999: Mazin A V; Kowalczykowski S C
A novel property of the RecA nucleoprotein filament: activation of double- stranded DNA for strand exchange in trans.
Genes & development 1999;13(15):2005-16.
1999: Harmon F G; DiGate R J; Kowalczykowski S C
RecQ helicase and topoisomerase III comprise a novel DNA strand passage function: a conserved mechanism for control of DNA recombination.
Molecular cell 1999;3(5):611-20.
1999: Churchill J J; Anderson D G; Kowalczykowski S C
The RecBC enzyme loads RecA protein onto ssDNA asymmetrically and independently of chi, resulting in constitutive recombination activation.
Genes & development 1999;13(7):901-11.
1999: Zaitsev E N; Kowalczykowski S C
The simultaneous binding of two double-stranded DNA molecules by Escherichia coli RecA protein.
Journal of molecular biology 1999;287(1):21-31.
1999: Zaitseva E M; Zaitsev E N; Kowalczykowski S C
The DNA binding properties of Saccharomyces cerevisiae Rad51 protein.
The Journal of biological chemistry 1999;274(5):2907-15.
1998: Anderson D G; Kowalczykowski S C
Reconstitution of an SOS response pathway: derepression of transcription in response to DNA breaks.
Cell 1998;95(7):975-9.
1998: Rehrauer W M; Bruck I; Woodgate R; Goodman M F; Kowalczykowski S C
Modulation of RecA nucleoprotein function by the mutagenic UmuD'C protein complex.
The Journal of biological chemistry 1998;273(49):32384-7.
1998: Ponomarenko M P; Ponomarenko Iu V; Titov I I; Kolchanov N A; Mazin A V; Kowalczykowski S C
[Preference of RecA-filament to the DNA sequences correlates with genetic code]
Doklady Akademii nauk / [Rossiiskaia akademii nauk] 1998;363(1):122-5.
1998: Anderson D G; Kowalczykowski S C
SSB protein controls RecBCD enzyme nuclease activity during unwinding: a new role for looped intermediates.
Journal of molecular biology 1998;282(2):275-85.
1998: Chédin F; Seitz E M; Kowalczykowski S C
Novel homologs of replication protein A in archaea: implications for the evolution of ssDNA-binding proteins.
Trends in biochemical sciences 1998;23(8):273-7.
1998: Arnold D A; Bianco P R; Kowalczykowski S C
The reduced levels of chi recognition exhibited by the RecBC1004D enzyme reflect its recombination defect in vivo.
The Journal of biological chemistry 1998;273(26):16476-86.
1998: Bianco P R; Tracy R B; Kowalczykowski S C
DNA strand exchange proteins: a biochemical and physical comparison.
Frontiers in bioscience : a journal and virtual library 1998;3():D570-603.
1998: Sugiyama T; New J H; Kowalczykowski S C
DNA annealing by RAD52 protein is stimulated by specific interaction with the complex of replication protein A and single-stranded DNA.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(11):6049-54.
1998: Seitz E M; Brockman J P; Sandler S J; Clark A J; Kowalczykowski S C
RadA protein is an archaeal RecA protein homolog that catalyzes DNA strand exchange.
Genes & development 1998;12(9):1248-53.
1998: Harmon F G; Kowalczykowski S C
RecQ helicase, in concert with RecA and SSB proteins, initiates and disrupts DNA recombination.
Genes & development 1998;12(8):1134-44.
1998: Mazin A V; Kowalczykowski S C
The function of the secondary DNA-binding site of RecA protein during DNA strand exchange.
The EMBO journal 1998;17(4):1161-8.
1998: New J H; Sugiyama T; Zaitseva E; Kowalczykowski S C
Rad52 protein stimulates DNA strand exchange by Rad51 and replication protein A.
Nature 1998;391(6665):407-10.
1998: Zaitsev E N; Kowalczykowski S C
Binding of double-stranded DNA by Escherichia coli RecA protein monitored by a fluorescent dye displacement assay.
Nucleic acids research 1998;26(2):650-4.
1997: Tracy R B; Baumohl J K; Kowalczykowski S C
The preference for GT-rich DNA by the yeast Rad51 protein defines a set of universal pairing sequences.
Genes & development 1997;11(24):3423-31.
1997: Tracy R B; Chédin F; Kowalczykowski S C
The recombination hot spot chi is embedded within islands of preferred DNA pairing sequences in the E. coli genome.
Cell 1997;90(2):205-6.
1997: Anderson D G; Kowalczykowski S C
The translocating RecBCD enzyme stimulates recombination by directing RecA protein onto ssDNA in a chi-regulated manner.
Cell 1997;90(1):77-86.
1997: Bianco P R; Kowalczykowski S C
The recombination hotspot Chi is recognized by the translocating RecBCD enzyme as the single strand of DNA containing the sequence 5'-GCTGGTGG-3'.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(13):6706-11.
1997: Anderson D G; Kowalczykowski S C
The recombination hot spot chi is a regulatory element that switches the polarity of DNA degradation by the RecBCD enzyme.
Genes & development 1997;11(5):571-81.
1997: Sugiyama T; Zaitseva E M; Kowalczykowski S C
A single-stranded DNA-binding protein is needed for efficient presynaptic complex formation by the Saccharomyces cerevisiae Rad51 protein.
The Journal of biological chemistry 1997;272(12):7940-5.
1997: Anderson D G; Churchill J J; Kowalczykowski S C
Chi-activated RecBCD enzyme possesses 5'-->3' nucleolytic activity, but RecBC enzyme does not: evidence suggesting that the alteration induced by Chi is not simply ejection of the RecD subunit.
Genes to cells : devoted to molecular & cellular mechanisms 1997;2(2):117-28.
1996: Mazin A V; Kowalczykowski S C
The specificity of the secondary DNA binding site of RecA protein defines its role in DNA strand exchange.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(20):10673-8.
1996: Harmon F G; Rehrauer W M; Kowalczykowski S C
Interaction of Escherichia coli RecA protein with LexA repressor. II. Inhibition of DNA strand exchange by the uncleavable LexA S119A repressor argues that recombination and SOS induction are competitive processes.
The Journal of biological chemistry 1996;271(39):23874-83.
1996: Rehrauer W M; Lavery P E; Palmer E L; Singh R N; Kowalczykowski S C
Interaction of Escherichia coli RecA protein with LexA repressor. I. LexA repressor cleavage is competitive with binding of a secondary DNA molecule.
The Journal of biological chemistry 1996;271(39):23865-73.
1996: Tracy R B; Kowalczykowski S C
In vitro selection of preferred DNA pairing sequences by the Escherichia coli RecA protein.
Genes & development 1996;10(15):1890-903.
1996: Rehrauer W M; Kowalczykowski S C
The DNA binding site(s) of the Escherichia coli RecA protein.
The Journal of biological chemistry 1996;271(20):11996-2002.
1996: Eggleston A K; Rahim N A; Kowalczykowski S C
A helicase assay based on the displacement of fluorescent, nucleic acid-binding ligands.
Nucleic acids research 1996;24(7):1179-86.
1995: Dixon D A; Kowalczykowski S C
Role of the Escherichia coli recombination hotspot, chi, in RecABCD-dependent homologous pairing.
The Journal of biological chemistry 1995;270(27):16360-70.
1995: Kowalczykowski S C; Krupp R A
DNA-strand exchange promoted by RecA protein in the absence of ATP: implications for the mechanism of energy transduction in protein-promoted nucleic acid transactions.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(8):3478-82.
1995: Eggleston A K; O'Neill T E; Bradbury E M; Kowalczykowski S C
Unwinding of nucleosomal DNA by a DNA helicase.
The Journal of biological chemistry 1995;270(5):2024-31.
1994: Kowalczykowski S C; Dixon D A; Eggleston A K; Lauder S D; Rehrauer W M
Biochemistry of homologous recombination in Escherichia coli.
Microbiological reviews 1994;58(3):401-65.
1994: Dixon D A; Churchill J J; Kowalczykowski S C
Reversible inactivation of the Escherichia coli RecBCD enzyme by the recombination hotspot chi in vitro: evidence for functional inactivation or loss of the RecD subunit.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(8):2980-4.
1994: Kowalczykowski S C
In vitro reconstitution of homologous recombination reactions.
Experientia 1994;50(3):204-15.
1994: Kowalczykowski S C; Eggleston A K
Homologous pairing and DNA strand-exchange proteins.
Annual review of biochemistry 1994;63():991-1043.
1993: Lauder S D; Kowalczykowski S C
Negative co-dominant inhibition of recA protein function. Biochemical properties of the recA1, recA13 and recA56 proteins and the effect of recA56 protein on the activities of the wild-type recA protein function in vitro.
Journal of molecular biology 1993;234(1):72-86.
1993: Allen M J; Dong X F; O'Neill T E; Yau P; Kowalczykowski S C; Gatewood J; Balhorn R; Bradbury E M
Atomic force microscope measurements of nucleosome cores assembled along defined DNA sequences.
Biochemistry 1993;32(33):8390-6.
1993: Eggleston A K; Kowalczykowski S C
The mutant recBCD enzyme, recB2109CD enzyme, has helicase activity but does not promote efficient joint molecule formation in vitro.
Journal of molecular biology 1993;231(3):621-33.
1993: Eggleston A K; Kowalczykowski S C
Biochemical characterization of a mutant recBCD enzyme, the recB2109CD enzyme, which lacks chi-specific, but not non-specific, nuclease activity.
Journal of molecular biology 1993;231(3):605-20.
1993: Dixon D A; Kowalczykowski S C
The recombination hotspot chi is a regulatory sequence that acts by attenuating the nuclease activity of the E. coli RecBCD enzyme.
Cell 1993;73(1):87-96.
1993: Rehrauer W M; Kowalczykowski S C
Alteration of the nucleoside triphosphate (NTP) catalytic domain within Escherichia coli recA protein attenuates NTP hydrolysis but not joint molecule formation.
The Journal of biological chemistry 1993;268(2):1292-7.
1992: Madiraju M V; Lavery P E; Kowalczykowski S C; Clark A J
Enzymatic properties of the RecA803 protein, a partial suppressor of recF mutations.
Biochemistry 1992;31(43):10529-35.
1992: Lavery P E; Kowalczykowski S C
Biochemical basis of the constitutive repressor cleavage activity of recA730 protein. A comparison to recA441 and recA803 proteins.
The Journal of biological chemistry 1992;267(29):20648-58.
1992: Lavery P E; Kowalczykowski S C
A postsynaptic role for single-stranded DNA-binding protein in recA protein-promoted DNA strand exchange.
The Journal of biological chemistry 1992;267(13):9315-20.
1992: Lavery P E; Kowalczykowski S C
Enhancement of recA protein-promoted DNA strand exchange activity by volume-occupying agents.
The Journal of biological chemistry 1992;267(13):9307-14.
1992: Menetski J P; Varghese A; Kowalczykowski S C
The physical and enzymatic properties of Escherichia coli recA protein display anion-specific inhibition.
The Journal of biological chemistry 1992;267(15):10400-4.
1992: Roman L J; Eggleston A K; Kowalczykowski S C
Processivity of the DNA helicase activity of Escherichia coli recBCD enzyme.
The Journal of biological chemistry 1992;267(6):4207-14.
1991: Dixon D A; Kowalczykowski S C
Homologous pairing in vitro stimulated by the recombination hotspot, Chi.
Cell 1991;66(2):361-71.
1991: Roman L J; Dixon D A; Kowalczykowski S C
RecBCD-dependent joint molecule formation promoted by the Escherichia coli RecA and SSB proteins.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(8):3367-71.
1991: Lauder S D; Kowalczykowski S C
Asymmetry in the recA protein-DNA filament.
The Journal of biological chemistry 1991;266(9):5450-8.
1991: Kowalczykowski S C
Biochemical and biological function of Escherichia coli RecA protein: behavior of mutant RecA proteins.
Biochimie 1991;73(2-3):289-304.
1991: Eggleston A K; Kowalczykowski S C
An overview of homologous pairing and DNA strand exchange proteins.
Biochimie 1991;73(2-3):163-76.
1991: Kowalczykowski S C
Biochemistry of genetic recombination: energetics and mechanism of DNA strand exchange.
Annual review of biophysics and biophysical chemistry 1991;20():539-75.
1990: Lavery P E; Kowalczykowski S C
Properties of recA441 protein-catalyzed DNA strand exchange can be attributed to an enhanced ability to compete with SSB protein.
The Journal of biological chemistry 1990;265(7):4004-10.
1990: Menetski J P; Kowalczykowski S C
Biochemical properties of the Escherichia coli recA430 protein. Analysis of a mutation that affects the interaction of the ATP-recA protein complex with single-stranded DNA.
Journal of molecular biology 1990;211(4):845-55.
1990: Menetski J P; Bear D G; Kowalczykowski S C
Stable DNA heteroduplex formation catalyzed by the Escherichia coli RecA protein in the absence of ATP hydrolysis.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(1):21-5.
1989: Roman L J; Kowalczykowski S C
Formation of heteroduplex DNA promoted by the combined activities of Escherichia coli recA and recBCD proteins.
The Journal of biological chemistry 1989;264(31):18340-8.
1989: Menetski J P; Kowalczykowski S C
Enhancement of Escherichia coli RecA protein enzymatic function by dATP.
Biochemistry 1989;28(14):5871-81.
1989: Kowalczykowski S C; Krupp R A
Biochemical events essential to the recombination activity of Escherichia coli RecA protein. II. Co-dominant effects of RecA142 protein on wild-type RecA protein function.
Journal of molecular biology 1989;207(4):735-47.
1989: Kowalczykowski S C; Burk D L; Krupp R A
Biochemical events essential to the recombination activity of Escherichia coli RecA protein. I. Properties of the mutant RecA142 protein.
Journal of molecular biology 1989;207(4):719-33.
1989: Roman L J; Kowalczykowski S C
Characterization of the adenosinetriphosphatase activity of the Escherichia coli RecBCD enzyme: relationship of ATP hydrolysis to the unwinding of duplex DNA.
Biochemistry 1989;28(7):2873-81.
1989: Roman L J; Kowalczykowski S C
Characterization of the helicase activity of the Escherichia coli RecBCD enzyme using a novel helicase assay.
Biochemistry 1989;28(7):2863-73.
1988: Lavery P E; Kowalczykowski S C
Biochemical basis of the temperature-inducible constitutive protease activity of the RecA441 protein of Escherichia coli.
Journal of molecular biology 1988;203(4):861-74.
1988: Benedict R C; Kowalczykowski S C
Increase of the DNA strand assimilation activity of recA protein by removal of the C terminus and structure-function studies of the resulting protein fragment.
The Journal of biological chemistry 1988;263(30):15513-20.
1988: Menetski J P; Varghese A; Kowalczykowski S C
Properties of the high-affinity single-stranded DNA binding state of the Escherichia coli recA protein.
Biochemistry 1988;27(4):1205-12.
1987: Kowalczykowski S C; Clow J; Krupp R A
Properties of the duplex DNA-dependent ATPase activity of Escherichia coli RecA protein and its role in branch migration.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(10):3127-31.
1987: Menetski J P; Kowalczykowski S C
Transfer of recA protein from one polynucleotide to another. Effect of ATP and determination of the processivity of ATP hydrolysis during transfer.
The Journal of biological chemistry 1987;262(5):2093-100.
1987: Menetski J P; Kowalczykowski S C
Transfer of recA protein from one polynucleotide to another. Kinetic evidence for a ternary intermediate during the transfer reaction.
The Journal of biological chemistry 1987;262(5):2085-92.
1987: Kowalczykowski S C; Krupp R A
Effects of Escherichia coli SSB protein on the single-stranded DNA-dependent ATPase activity of Escherichia coli RecA protein. Evidence that SSB protein facilitates the binding of RecA protein to regions of secondary structure within single-stranded DNA.
Journal of molecular biology 1987;193(1):97-113.
1986: Roman L J; Kowalczykowski S C
Relationship of the physical and enzymatic properties of Escherichia coli recA protein to its strand exchange activity.
Biochemistry 1986;25(23):7375-85.
1985: Menetski J P; Kowalczykowski S C
Interaction of recA protein with single-stranded DNA. Quantitative aspects of binding affinity modulation by nucleotide cofactors.
Journal of molecular biology 1985;181(2):281-95.

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