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Elizabeth Kowaluk

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Mark A Matulenko; Ernest S Paight; Robin R Frey; Arthur Gomtsyan; Stanley Didomenico; Meiqun Jiang; Abel Lee; Andrew O Stewart; Haixia Yu; Kathy L Kohlhaas; Easaw Alexander; Steve McGaraughty; Joe Mikusa; Kennan Marsh; Steven W Muchmore; Clarissa L Jakob; Elizabeth A Kowaluk; Michael F Jarvis; Shripad S Bhagwat
4-amino-5-aryl-6-arylethynylpyrimidines: structure-activity relationships of non-nucleoside adenosine kinase inhibitors.
Steven W Muchmore; Richard A Smith; Andrew O Stewart; Marlon D Cowart; Arthur Gomtsyan; Mark A Matulenko; Haixia Yu; Jean M Severin; Shripad S Bhagwat; Abel Lee; Elizabeth A Kowaluk; Michael F Jarvis; Clarissa L Jakob
Crystal structures of human adenosine kinase inhibitor complexes reveal two distinct binding modes.
Mark A Matulenko; Abel Lee; Meiqun Jiang; Robin R Frey; Marlon D Cowart; Erol K Bayburt; Stanley Didomenico; Gregory A Gfesser; Arthur Gomtsyan; Guo Zhu Zheng; Jeffrey A McKie; Andrew O Stewart; Haixia Yu; Kathy L Kohlhaas; Easaw Alexander; Steve McGaraughty; Carol T Wismer; Joe Mikusa; Kennan Marsh; Ronald D Snyder; Marilyn S Diehl; Elizabeth A Kowaluk; Michael F Jarvis; Shripad S Bhagwat
5-(3-Bromophenyl)-7-(6-morpholin-4-ylpyridin-3-yl)pyrido[2,3-d]pyrimidin-4-ylamine: structure-activity relationships of 7-substituted heteroaryl analogs as non-nucleoside adenosine kinase inhibitors.

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All Publications

2007: Mark A Matulenko; Ernest S Paight; Robin R Frey; Arthur Gomtsyan; Stanley Didomenico; Meiqun Jiang; Abel Lee; Andrew O Stewart; Haixia Yu; Kathy L Kohlhaas; Easaw Alexander; Steve McGaraughty; Joe Mikusa; Kennan Marsh; Steven W Muchmore; Clarissa L Jakob; Elizabeth A Kowaluk; Michael F Jarvis; Shripad S Bhagwat
4-amino-5-aryl-6-arylethynylpyrimidines: structure-activity relationships of non-nucleoside adenosine kinase inhibitors.
Bioorganic & medicinal chemistry 2007;15(4):1586-605.
2006: Steven W Muchmore; Richard A Smith; Andrew O Stewart; Marlon D Cowart; Arthur Gomtsyan; Mark A Matulenko; Haixia Yu; Jean M Severin; Shripad S Bhagwat; Abel Lee; Elizabeth A Kowaluk; Michael F Jarvis; Clarissa L Jakob
Crystal structures of human adenosine kinase inhibitor complexes reveal two distinct binding modes.
Journal of medicinal chemistry 2006;49(23):6726-31.
2005: Mark A Matulenko; Abel Lee; Meiqun Jiang; Robin R Frey; Marlon D Cowart; Erol K Bayburt; Stanley Didomenico; Gregory A Gfesser; Arthur Gomtsyan; Guo Zhu Zheng; Jeffrey A McKie; Andrew O Stewart; Haixia Yu; Kathy L Kohlhaas; Easaw Alexander; Steve McGaraughty; Carol T Wismer; Joe Mikusa; Kennan Marsh; Ronald D Snyder; Marilyn S Diehl; Elizabeth A Kowaluk; Michael F Jarvis; Shripad S Bhagwat
5-(3-Bromophenyl)-7-(6-morpholin-4-ylpyridin-3-yl)pyrido[2,3-d]pyrimidin-4-ylamine: structure-activity relationships of 7-substituted heteroaryl analogs as non-nucleoside adenosine kinase inhibitors.
Bioorganic & medicinal chemistry 2005;13(11):3705-20.
2004: Arthur Gomtsyan; Stanley Didomenico; Abel Lee; Andrew O Stewart; Shripad S Bhagwat; Elizabeth A Kowaluk; Michael F Jarvis
Synthesis and biological evaluation of pteridine and pyrazolopyrimidine based adenosine kinase inhibitors.
Bioorganic & medicinal chemistry letters 2004;14(16):4165-8.
2003: Richard J Perner; Yu Gui Gu; Abel Lee; Erol K Bayburt; Jeffrey A McKie; Easaw Alexander; Kathy L Kohlhaas; Carol T Wismer; Joe Mikusa; Michael F Jarvis; Elizabeth A Kowaluk; Shripad S Bhagwat
5,6,7-trisubstituted 4-aminopyrido[2,3-d]pyrimidines as novel inhibitors of adenosine kinase.
Journal of medicinal chemistry 2003;46(24):5249-57.
2003: Guo Zhu Zheng; Yue Mao; Abel Lee; John K Pratt; John R Koenig; Richard J Perner; Marlon D Cowart; Gregory A Gfesser; Steve McGaraughty; Katharine L Chu; Chang Zhu; Haixia Yu; Kathy L Kohlhaas; Easaw Alexander; Carol T Wismer; Joe Mikusa; Michael F Jarvis; Elizabeth A Kowaluk; Andrew O Stewart
Adenosine kinase inhibitors: polar 7-substitutent of pyridopyrimidine derivatives improving their locomotor selectivity.
Bioorganic & medicinal chemistry letters 2003;13(18):3041-4.
2003: Gregory A Gfesser; Erol K Bayburt; Marlon D Cowart; Stanley Didomenico; Arthur Gomtsyan; Chih Hung Lee; Andrew O Stewart; Michael F Jarvis; Elizabeth A Kowaluk; Shripad S Bhagwat
Synthesis and structure-activity relationships of 5-heteroatom-substituted pyridopyrimidines as adenosine kinase inhibitors.
European journal of medicinal chemistry 2003;38(3):245-52.
2002: Michael F Jarvis; Edward C Burgard; Steve McGaraughty; Prisca Honore; Kevin Lynch; Timothy Brennan; Alberto Subieta; Tim Van Biesen; Jayne Cartmell; Bruce R Bianchi; Wende Niforatos; Karen Kage; Haixia Yu; Joe Mikusa; Carol T Wismer; Chang Z Zhu; Katharine Chu; Abel Lee; Andrew O Stewart; James S Polakowski; Bryan Cox; Elizabeth A Kowaluk; Michael Williams; James Sullivan; Connie R Faltynek
A-317491, a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(26):17179-84.
2002: Michael F Jarvis; Joe Mikusa; Katharine L Chu; Carol T Wismer; Prisca Honore; Elizabeth A Kowaluk; Steve McGaraughty
Comparison of the ability of adenosine kinase inhibitors and adenosine receptor agonists to attenuate thermal hyperalgesia and reduce motor performance in rats.
Pharmacology, biochemistry, and behavior 2002;73(3):573-81.
2002: Arthur Gomtsyan; Stanley Didomenico; Abel Lee; Mark A Matulenko; Ki Kim; Elizabeth A Kowaluk; Carol T Wismer; Joe Mikusa; Haixia Yu; Kathy L Kohlhaas; Michael F Jarvis; Shripad S Bhagwat
Design, synthesis, and structure-activity relationship of 6-alkynylpyrimidines as potent adenosine kinase inhibitors.
Journal of medicinal chemistry 2002;45(17):3639-48.
2002: Michael F Jarvis; Haixia Yu; Steve McGaraughty; Carol T Wismer; Joe Mikusa; Chang Zhu; Katharine Chu; Kathy L Kohlhaas; Marlon D Cowart; Chih Hung Lee; Andrew O Stewart; Bryan Cox; James S Polakowski; Elizabeth A Kowaluk
Analgesic and anti-inflammatory effects of A-286501, a novel orally active adenosine kinase inhibitor.
Pain 2002;96(1-2):107-18.
2001: Guo Zhu Zheng; C Lee; John K Pratt; Richard J Perner; M Q Jiang; Arthur Gomtsyan; Mark A Matulenko; Yue Mao; John R Koenig; Ki H Kim; Steven W Muchmore; Haixia Yu; Kathy L Kohlhaas; Easaw Alexander; Steve McGaraughty; Katharine L Chu; Carol T Wismer; Joe Mikusa; Michael F Jarvis; Kennan Marsh; Elizabeth A Kowaluk; Shripad S Bhagwat; Andrew O Stewart
Pyridopyrimidine analogues as novel adenosine kinase inhibitors.
Bioorganic & medicinal chemistry letters 2001;11(16):2071-4.
2001: Chang Z Zhu; Joe Mikusa; Katharine L Chu; Marlon D Cowart; Elizabeth A Kowaluk; Michael F Jarvis; Steve McGaraughty
A-134974: a novel adenosine kinase inhibitor, relieves tactile allodynia via spinal sites of action in peripheral nerve injured rats.
Brain research 2001;905(1-2):104-10.
2001: Chih Hung Lee; Meiqun Jiang; Marlon D Cowart; Gregory A Gfesser; Richard J Perner; Ki H Kim; Yu Gui Gu; Michael Williams; Michael F Jarvis; Elizabeth A Kowaluk; Andrew O Stewart; Shripad S Bhagwat
Discovery of 4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido[2,3-d]pyrimidine, an orally active, non-nucleoside adenosine kinase inhibitor..
Journal of medicinal chemistry 2001;44(13):2133-8.
2001: Steve McGaraughty; Katharine L Chu; Carol T Wismer; Joe Mikusa; Chang Z Zhu; Marlon D Cowart; Elizabeth A Kowaluk; Michael F Jarvis
Effects of A-134974, a novel adenosine kinase inhibitor, on carrageenan-induced inflammatory hyperalgesia and locomotor activity in rats: evaluation of the sites of action.
The Journal of pharmacology and experimental therapeutics 2001;296(2):501-9.
2001: David L Boyle; Elizabeth A Kowaluk; Michael F Jarvis; C H Lee; Shripad S Bhagwat; M Williams; Gary S Firestein
Anti-inflammatory effects of ABT-702, a novel non-nucleoside adenosine kinase inhibitor, in rat adjuvant arthritis.
The Journal of pharmacology and experimental therapeutics 2001;296(2):495-500.
2001: Marlon D Cowart; Chih Hung Lee; Gregory A Gfesser; Erol K Bayburt; Shripad S Bhagwat; Andrew O Stewart; Haixia Yu; Kathy L Kohlhaas; Steve McGaraughty; Carol T Wismer; Joe Mikusa; Chang Zhu; Easaw Alexander; Michael F Jarvis; Elizabeth A Kowaluk
Structure-activity studies of 5-substituted pyridopyrimidines as adenosine kinase inhibitors.
Bioorganic & medicinal chemistry letters 2001;11(1):83-6.
2001: Michael F Jarvis; Carol T Wismer; E Schweitzer; Haixia Yu; Kevin J Lynch; Edward C Burgard; Elizabeth A Kowaluk
Modulation of BzATP and formalin induced nociception: attenuation by the P2X receptor antagonist, TNP-ATP and enhancement by the P2X(3) allosteric modulator, cibacron blue.
British journal of pharmacology 2001;132(1):259-69.
2000: Philip J Hajduk; Arthur Gomtsyan; Stanley Didomenico; Marlon D Cowart; Erol K Bayburt; Larry Solomon; Jean M Severin; Richard Smith; Karl Walter; Thomas F Holzman; A Stewart; Steve McGaraughty; Michael F Jarvis; Elizabeth A Kowaluk; Stephen W Fesik
Design of adenosine kinase inhibitors from the NMR-based screening of fragments.
Journal of medicinal chemistry 2000;43(25):4781-6.
2000: Edward C Burgard; Wende Niforatos; Tim Van Biesen; Kevin J Lynch; Karen Kage; E Touma; Elizabeth A Kowaluk; Michael F Jarvis
Competitive antagonism of recombinant P2X(2/3) receptors by 2', 3'-O-(2,4,6-trinitrophenyl) adenosine 5'-triphosphate (TNP-ATP).
Molecular pharmacology 2000;58(6):1502-10.
2000: Elizabeth A Kowaluk; Joe Mikusa; Carol T Wismer; Chang Z Zhu; E Schweitzer; James J Lynch; Chih Hung Lee; Meiqun Jiang; Shripad S Bhagwat; Arthur Gomtsyan; Jeffrey A McKie; Bryan Cox; James S Polakowski; G Reinhart; Michael Williams; Michael F Jarvis
ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin- 3-yl)pyrido[2,3-d]pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory properties. II. In vivo characterization in the rat.
The Journal of pharmacology and experimental therapeutics 2000;295(3):1165-74.
2000: Michael F Jarvis; Haixia Yu; Kathy L Kohlhaas; K Alexander; Chih Hung Lee; Meiqun Jiang; Shripad S Bhagwat; Michael Williams; Elizabeth A Kowaluk
ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholinopyridin-3-yl)pyrido[2, 3-d]pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory properties: I. In vitro characterization and acute antinociceptive effects in the mouse.
The Journal of pharmacology and experimental therapeutics 2000;295(3):1156-64.
2000: Elizabeth A Kowaluk; Michael F Jarvis
Therapeutic potential of adenosine kinase inhibitors.
Expert opinion on investigational drugs 2000;9(3):551-64.
2000: Michael F Jarvis; Jerry L Wessale; Chang Z Zhu; James J Lynch; Brian D Dayton; Samuel V Calzadilla; Robert J Padley; Terry J Opgenorth; Elizabeth A Kowaluk
ABT-627, an endothelin ET(A) receptor-selective antagonist, attenuates tactile allodynia in a diabetic rat model of neuropathic pain.
European journal of pharmacology 2000;388(1):29-35.
1999: Kevin J Lynch; E Touma; Wende Niforatos; Karen Kage; Edward C Burgard; Tim Van Biesen; Elizabeth A Kowaluk; Michael F Jarvis
Molecular and functional characterization of human P2X(2) receptors.
Molecular pharmacology 1999;56(6):1171-81.
1999: K Alexander; Wende Niforatos; Bruce R Bianchi; Edward C Burgard; Kevin J Lynch; Elizabeth A Kowaluk; Michael F Jarvis; Tim Van Biesen
Allosteric modulation and accelerated resensitization of human P2X(3) receptors by cibacron blue.
The Journal of pharmacology and experimental therapeutics 1999;291(3):1135-42.
1999: Edward C Burgard; Wende Niforatos; Tim Van Biesen; Kevin J Lynch; E Touma; R E Metzger; Elizabeth A Kowaluk; Michael F Jarvis
P2X receptor-mediated ionic currents in dorsal root ganglion neurons.
Journal of neurophysiology 1999;82(3):1590-8.
1999: Bruce R Bianchi; Kevin J Lynch; E Touma; Wende Niforatos; Edward C Burgard; Easaw Alexander; H S Park; Haixia Yu; R Metzger; Elizabeth A Kowaluk; Michael F Jarvis; Tim Van Biesen
Pharmacological characterization of recombinant human and rat P2X receptor subtypes.
European journal of pharmacology 1999;376(1-2):127-38.
1999: DR Britton; Joe Mikusa; Chih Hung Lee; Michael F Jarvis; Michael Williams; Elizabeth A Kowaluk
Site and event specific increase of striatal adenosine release by adenosine kinase inhibition in rats.
Neuroscience letters 1999;266(2):93-6.
1999: Michael Williams; Elizabeth A Kowaluk; Stephen P Arneric
Emerging molecular approaches to pain therapy.
Journal of medicinal chemistry 1999;42(9):1481-500.
1999: Elizabeth A Kowaluk; Kathy L Kohlhaas; AW Bannon; KL Gunther; James J Lynch; Michael F Jarvis
Characterization of the effects of adenosine kinase inhibitors on acute thermal nociception in mice.
Pharmacology, biochemistry, and behavior 1999;63(1):83-91.
1999: James J Lynch; Michael F Jarvis; Elizabeth A Kowaluk
An adenosine kinase inhibitor attenuates tactile allodynia in a rat model of diabetic neuropathic pain.
European journal of pharmacology 1999;364(2-3):141-6.
1998: Elizabeth A Kowaluk; Shripad S Bhagwat; Michael F Jarvis
Adenosine kinase inhibitors.
Current pharmaceutical design 1998;4(5):403-16.
1998: James J Lynch; Easaw Alexander; Michael F Jarvis; Elizabeth A Kowaluk
Inhibition of adenosine kinase during oxygen-glucose deprivation in rat cortical neuronal cultures.
Neuroscience letters 1998;252(3):207-10.
1998: Marlon D Cowart; Elizabeth A Kowaluk; Jerome F Daanen; Kathy L Kohlhaas; Easaw Alexander; Frank L Wagenaar; James Kerwin
Nitroaromatic amino acids as inhibitors of neuronal nitric oxide synthase.
Journal of medicinal chemistry 1998;41(14):2636-42.
1998: Elizabeth A Kowaluk
Adenosine modulation: a novel approach to analgesia and inflammation.
Expert opinion on investigational drugs 1998;7(4):535-43.
1997: Teresa McNally; Rosalind J Helfrich; Marlon D Cowart; Sarah A Dorwin; Joseph L Meuth; K B Idler; K A Klute; Robert L Simmer; Elizabeth A Kowaluk; Donald N Halbert
Cloning and expression of the adenosine kinase gene from rat and human tissues.
Biochemical and biophysical research communications 1997;231(3):645-50.