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K Koyama

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YT Zhou; Michio Shimabukuro; Young Lee; K Koyama; M Higa; T Ferguson; Roger H Unger
Enhanced de novo lipogenesis in the leptin-unresponsive pancreatic islets of prediabetic Zucker diabetic fatty rats: role in the pathogenesis of lipotoxic diabetes.
May-Yun Wang; K Koyama; Michio Shimabukuro; David J Mangelsdorf; Christopher B Newgard; Roger H Unger
Overexpression of leptin receptors in pancreatic islets of Zucker diabetic fatty rats restores GLUT-2, glucokinase, and glucose-stimulated insulin secretion.
K Koyama; Michio Shimabukuro; Guoxun Chen; May-Yun Wang; Young Lee; Pushpa S Kalra; M G Dube; SP Kalra; Christopher B Newgard; Roger H Unger
Resistance to adenovirally induced hyperleptinemia in rats. Comparison of ventromedial hypothalamic lesions and mutated leptin receptors.

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All Publications

1998: YT Zhou; Michio Shimabukuro; Young Lee; K Koyama; M Higa; T Ferguson; Roger H Unger
Enhanced de novo lipogenesis in the leptin-unresponsive pancreatic islets of prediabetic Zucker diabetic fatty rats: role in the pathogenesis of lipotoxic diabetes.
Diabetes 1998;47(12):1904-8.
1998: May-Yun Wang; K Koyama; Michio Shimabukuro; David J Mangelsdorf; Christopher B Newgard; Roger H Unger
Overexpression of leptin receptors in pancreatic islets of Zucker diabetic fatty rats restores GLUT-2, glucokinase, and glucose-stimulated insulin secretion.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(20):11921-6.
1998: K Koyama; Michio Shimabukuro; Guoxun Chen; May-Yun Wang; Young Lee; Pushpa S Kalra; M G Dube; SP Kalra; Christopher B Newgard; Roger H Unger
Resistance to adenovirally induced hyperleptinemia in rats. Comparison of ventromedial hypothalamic lesions and mutated leptin receptors.
The Journal of clinical investigation 1998;102(4):728-33.
1998: May-Yun Wang; K Koyama; Michio Shimabukuro; Christopher B Newgard; Roger H Unger
OB-Rb gene transfer to leptin-resistant islets reverses diabetogenic phenotype.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(2):714-8.
1997: YT Zhou; Michio Shimabukuro; Young Lee; K Koyama; F Trieu; Roger H Unger
Leptin normalizes the impaired response of proinsulin mRNA to long chain fatty acids in heterozygous Zucker diabetic fatty rats.
The Journal of biological chemistry 1997;272(41):25648-51.
1997: Michio Shimabukuro; K Koyama; Young Lee; Roger H Unger
Leptin- or troglitazone-induced lipopenia protects islets from interleukin 1beta cytotoxicity.
The Journal of clinical investigation 1997;100(7):1750-4.
1997: YT Zhou; Michio Shimabukuro; K Koyama; Young Lee; May-Yun Wang; F Trieu; Christopher B Newgard; Roger H Unger
Induction by leptin of uncoupling protein-2 and enzymes of fatty acid oxidation.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(12):6386-90.
1997: Michio Shimabukuro; K Koyama; Guoxun Chen; May-Yun Wang; F Trieu; Young Lee; Christopher B Newgard; Roger H Unger
Direct antidiabetic effect of leptin through triglyceride depletion of tissues.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(9):4637-41.
1996: Guoxun Chen; K Koyama; X Yuan; Young Lee; YT Zhou; R O'Doherty; Christopher B Newgard; Roger H Unger
Disappearance of body fat in normal rats induced by adenovirus-mediated leptin gene therapy.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(25):14795-9.