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Rumiana Koynova

Research Profile

Procedures

Calorimetry, Differential Scanning

Phenomena

Occupations

Thermodynamics

Chemicals & Drugs

Physiology

Transfection

Concepts & Ideas

Anatomy

Lipid Bilayers

Genes & Molecular Sequences

Molecular Structure

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Publications

TOP 3
Boris Tenchov; Rumiana Koynova
Cubic phases in membrane lipids.
Boris Tenchov; Yasuro Sugimoto; Robert W Brueggemeier; Rumiana Koynova; Robert J Lee
Highly efficient cationic ethylphosphatidylcholine siRNA carrier for GFP suppression in modified breast cancer cells.
Tianyao Huo; Rumiana Koynova; Robin J Nakkula; Boris Tenchov; Weilian Yang; Lawrence Agius; Rolf F Barth; Teni Boulikas; Abhik Ray Chaudhury; Hélène Elleaume; Robert J Lee
Preparation, biodistribution and neurotoxicity of liposomal cisplatin following convection enhanced delivery in normal and F98 glioma bearing rats.

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All Publications

2012: Boris Tenchov; Rumiana Koynova
Cubic phases in membrane lipids.
European biophysics journal : EBJ 2012;41(10):841-50.
2012: Boris Tenchov; Yasuro Sugimoto; Robert W Brueggemeier; Rumiana Koynova; Robert J Lee
Highly efficient cationic ethylphosphatidylcholine siRNA carrier for GFP suppression in modified breast cancer cells.
Anticancer research 2012;32(7):2563-6.
2012: Tianyao Huo; Rumiana Koynova; Robin J Nakkula; Boris Tenchov; Weilian Yang; Lawrence Agius; Rolf F Barth; Teni Boulikas; Abhik Ray Chaudhury; Hélène Elleaume; Robert J Lee
Preparation, biodistribution and neurotoxicity of liposomal cisplatin following convection enhanced delivery in normal and F98 glioma bearing rats.
PloS one 2012;7(11):e48752.
2011: Rumiana Koynova; Boris Tenchov
Recent patents in cationic lipid carriers for delivery of nucleic acids.
Recent patents on DNA & gene sequences 2011;5(1):8-27.
2010: Radka Vladkova; Rumiana Koynova; Klaus Teuchner; Boris Tenchov
Bilayer structural destabilization by low amounts of chlorophyll a.
Biochimica et biophysica acta 2010;1798(8):1586-92.
2010: Yu Zheng; Bo Yu; Wanlop Weecharangsan; Longzhu Piao; Michael Darby; Yicheng Mao; Rumiana Koynova; Xiaojuan Yang; Hong Li; Songlin Xu; L James Lee; Sugimoto Yasuro; Robert W Brueggemeier; Robert J Lee
Transferrin-conjugated lipid-coated PLGA nanoparticles for targeted delivery of aromatase inhibitor 7alpha-APTADD to breast cancer cells.
International journal of pharmaceutics 2010;390(2):234-41.
2010: Rumiana Koynova; Mariana Tihova
Nanosized self-emulsifying lipid vesicles of diacylglycerol-PEG lipid conjugates: biophysical characterization and inclusion of lipophilic dietary supplements.
Biochimica et biophysica acta 2010;1798(3):646-53.
2010: Rumiana Koynova; Boris Tenchov
Cationic lipids: molecular structure/ transfection activity relationships and interactions with biomembranes.
Topics in current chemistry 2010;296():51-93.
2010: Rumiana Koynova
Analysis of lipoplex structure and lipid phase changes.
Methods in molecular biology (Clifton, N.J.) 2010;606():399-423.
2009: Rumiana Koynova; Boris Tenchov; Li Wang; Robert C Macdonald
Hydrophobic moiety of cationic lipids strongly modulates their transfection activity.
Molecular pharmaceutics 2009;6(3):951-8.
2008: Boris Tenchov; Li Wang; Rumiana Koynova; Robert C MacDonald
Modulation of a membrane lipid lamellar-nonlamellar phase transition by cationic lipids: a measure for transfection efficiency.
Biochimica et biophysica acta 2008;1778(10):2405-12.
2008: Rumiana Koynova; Li Wang; Robert C Macdonald
Cationic phospholipids forming cubic phases: lipoplex structure and transfection efficiency.
Molecular pharmaceutics 2008;5(5):739-44.
2007: Rumiana Koynova; Robert C MacDonald
Natural lipid extracts and biomembrane-mimicking lipid compositions are disposed to form nonlamellar phases, and they release DNA from lipoplexes most efficiently.
Biochimica et biophysica acta 2007;1768(10):2373-82.
2007: Rumiana Koynova; Li Wang; Robert C MacDonald
Synergy in lipofection by cationic lipid mixtures: superior activity at the gel-liquid crystalline phase transition.
The journal of physical chemistry. B 2007;111(27):7786-95.
2007: Rumiana Koynova; Yury S Tarahovsky; Li Wang; Robert C MacDonald
Lipoplex formulation of superior efficacy exhibits high surface activity and fusogenicity, and readily releases DNA.
Biochimica et biophysica acta 2007;1768(2):375-86.
2006: Li Wang; Rumiana Koynova; Harsh Parikh; Robert C MacDonald
Transfection activity of binary mixtures of cationic o-substituted phosphatidylcholine derivatives: the hydrophobic core strongly modulates physical properties and DNA delivery efficacy.
Biophysical journal 2006;91(10):3692-706.
2006: Rumiana Koynova; Li Wang; Robert C MacDonald
An intracellular lamellar-nonlamellar phase transition rationalizes the superior performance of some cationic lipid transfection agents.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(39):14373-8.
2005: Rumiana Koynova; Li Wang; Yury S Tarahovsky; Robert C MacDonald
Lipid phase control of DNA delivery.
Bioconjugate chemistry 2005;16(6):1335-9.
2005: Rumiana Koynova; Robert C MacDonald
Lipid transfer between cationic vesicles and lipid-DNA lipoplexes: effect of serum.
Biochimica et biophysica acta 2005;1714(1):63-70.
2004: Yury S Tarahovsky; Rumiana Koynova; Robert C MacDonald
DNA release from lipoplexes by anionic lipids: correlation with lipid mesomorphism, interfacial curvature, and membrane fusion.
Biophysical journal 2004;87(2):1054-64.
2004: Rumiana Koynova; Howard Rosenzweig; Li Wang; Michael R Wasielewski; Robert C MacDonald
Novel fluorescent cationic phospholipid, O-4-napthylimido-1-butyl-DOPC, exhibits unusual foam morphology, forms hexagonal and cubic phases in mixtures, and transfects DNA.
Chemistry and physics of lipids 2004;129(2):183-94.
2003: Rumiana Koynova; Robert C MacDonald
Mixtures of cationic lipid O-ethylphosphatidylcholine with membrane lipids and DNA: phase diagrams.
Biophysical journal 2003;85(4):2449-65.
2003: Rumiana Koynova; Robert C MacDonald
Cationic O-ethylphosphatidylcholines and their lipoplexes: phase behavior aspects, structural organization and morphology.
Biochimica et biophysica acta 2003;1613(1-2):39-48.
2002: Rumiana Koynova; Martin Caffrey
An index of lipid phase diagrams.
Chemistry and physics of lipids 2002;115(1-2):107-219.
2001: Boris Tenchov; Rumiana Koynova; G Rapp
New ordered metastable phases between the gel and subgel phases in hydrated phospholipids.
Biophysical journal 2001;80(4):1873-90.
2000: R Vladkov; Klaus Teuchner; Dieter Leupold; Rumiana Koynova; Boris Tenchov
Detection of the metastable rippled gel phase in hydrated phosphatidylcholine by fluorescence spectroscopy.
Biophysical chemistry 2000;84(2):159-66.
2000: R Komsa-Penkova; Rumiana Koynova; G Kostov; Boris Tenchov
Discrete reduction of type I collagen thermal stability upon oxidation.
Biophysical chemistry 2000;83(3):185-95.
1999: Boris Tenchov; Rumiana Koynova; Michael Rappolt; G Rapp
An ordered metastable phase in hydrated phosphatidylethanolamine: the Y-transition.
Biochimica et biophysica acta 1999;1417(1):183-90.
1998: Boris Tenchov; Rumiana Koynova; G Rapp
Accelerated formation of cubic phases in phosphatidylethanolamine dispersions.
Biophysical journal 1998;75(2):853-66.
1998: Rumiana Koynova; M Caffrey
Phases and phase transitions of the phosphatidylcholines.
Biochimica et biophysica acta 1998;1376(1):91-145.
1997: Rumiana Koynova; Boris Tenchov; G Rapp
Low amounts of PEG-lipid induce cubic phase in phosphatidylethanolamine dispersions.
Biochimica et biophysica acta 1997;1326(2):167-70.
1997: Rumiana Koynova; Jordan Brankov; Boris Tenchov
Modulation of lipid phase behavior by kosmotropic and chaotropic solutes : Experiment and thermodynamic theory.
European biophysics journal : EBJ 1997;25(4):261-74.
1996: Boris Tenchov; M Rappolt; Rumiana Koynova; G Rapp
New phases induced by sucrose in saturated phosphatidylethanolamines: an expanded lamellar gel phase and a cubic phase.
Biochimica et biophysica acta 1996;1285(1):109-22.
1996: Rumiana Koynova; A Koumanov; Boris Tenchov
Metastable rippled gel phase in saturated phosphatidylcholines: calorimetric and densitometric characterization.
Biochimica et biophysica acta 1996;1285(1):101-8.
1996: R Komsa-Penkova; Rumiana Koynova; G Kostov; Boris Tenchov
Thermal stability of calf skin collagen type I in salt solutions.
Biochimica et biophysica acta 1996;1297(2):171-81.
1995: Rumiana Koynova; Boris Tenchov; S Todinova; Peter J Quinn
Rapid reversible formation of a metastable subgel phase in saturated diacylphosphatidylcholines.
Biophysical journal 1995;68(6):2370-5.
1995: Rumiana Koynova; Martin Caffrey
Phases and phase transitions of the sphingolipids.
Biochimica et biophysica acta 1995;1255(3):213-36.
1994: S G Taneva; Rumiana Koynova; Boris Tenchov
Thermal stability of lipid-depleted purple membranes at neutral and low pH values.
FEBS letters 1994;345(2-3):154-8.
1994: Rumiana Koynova; Martin Caffrey
Phases and phase transitions of the glycoglycerolipids.
Chemistry and physics of lipids 1994;69(3):181-207.
1994: Rumiana Koynova; Martin Caffrey
Phases and phase transitions of the hydrated phosphatidylethanolamines.
Chemistry and physics of lipids 1994;69(1):1-34.
1993: Rumiana Koynova; Boris Tenchov; H Kuttenreich; Hans-Jürgen Hinz
Structure and phase behavior of a charged glycolipid (1,2-O-dialkyl-3-O-beta-D-glucuronosyl-sn-glycerol).
Biochemistry 1993;32(46):12437-45.
1993: H Kuttenreich; Hans-Jürgen Hinz; Rumiana Koynova; Boris Tenchov
Different phase behaviour of the sn-1 and sn-3 stereoisomers of the glycolipid di-tetradecyl-beta-D-galactosylglycerol.
Chemistry and physics of lipids 1993;66(1-2):55-62.
1993: Rumiana Koynova; Martin Caffrey
Mesophase transition temperatures as measured by fluorescence and calorimetry.
Biophysical journal 1993;65(1):550-1.
1991: Peter Laggner; Karl Lohner; Rumiana Koynova; Boris Tenchov
The influence of low amounts of cholesterol on the interdigitated gel phase of hydrated dihexadecylphosphatidylcholine.
Chemistry and physics of lipids 1991;60(2):153-61.
1991: Hans-Jürgen Hinz; H Kuttenreich; R Meyer; M Renner; Rüdiger Fründ; Rumiana Koynova; A I Boyanov; Boris Tenchov
Stereochemistry and size of sugar head groups determine structure and phase behavior of glycolipid membranes: densitometric, calorimetric, and X-ray studies.
Biochemistry 1991;30(21):5125-38.
1991: W Patrick Williams; Peter J Quinn; L I Tsonev; Rumiana Koynova
The effects of glycerol on the phase behaviour of hydrated distearoylphosphatidylethanolamine and its possible relation to the mode of action of cryoprotectants.
Biochimica et biophysica acta 1991;1062(2):123-32.
1990: Rumiana Koynova; Hans-Jürgen Hinz
Metastable behaviour of saturated phosphatidylethanolamines: a densitometric study.
Chemistry and physics of lipids 1990;54(1):67-72.
1989: T D Tsvetkov; L I Tsonev; N M Tsvetkova; Rumiana Koynova; Boris Tenchov
Effect of trehalose on the phase properties of hydrated and lyophilized dipalmitoylphosphatidylcholine multilayers.
Cryobiology 1989;26(2):162-9.
1988: Rumiana Koynova; Boris Tenchov; Peter J Quinn; P Laggner
Structure and phase behavior of hydrated mixtures of L-dipalmitoylphosphatidylcholine and palmitic acid. Correlations between structural rearrangements, specific volume changes and endothermic events.
Chemistry and physics of lipids 1988;48(3-4):205-14.
1988: Peter J Quinn; Rumiana Koynova; L J Lis; Boris Tenchov
Lamellar gel-lamellar liquid crystal phase transition of dipalmitoylphosphatidylcholine multilayers freeze-dried from aqueous trehalose solutions. A real-time X-ray diffraction study.
Biochimica et biophysica acta 1988;942(2):315-23.
1988: Rumiana Koynova; H L Kuttenreich; Boris Tenchov; Hans-Jürgen Hinz
Influence of head-group interactions on the miscibility of synthetic, stereochemically pure glycolipids and phospholipids.
Biochemistry 1988;27(13):4612-9.
1986: A I Boyanov; Rumiana Koynova; Boris Tenchov
Effect of lipid admixtures on the L-dipalmitoylphosphatidylcholine subtransition.
Chemistry and physics of lipids 1986;39(1-2):155-63.
1985: Boris Tenchov; T K Yanev; Mariana Tihova; Rumiana Koynova
A probability concept about size distributions of sonicated lipid vesicles.
Biochimica et biophysica acta 1985;816(1):122-30.
1985: Boris Tenchov; Rumiana Koynova
The effect of nonideal lateral mixing on the transmembrane lipid asymmetry.
Biochimica et biophysica acta 1985;815(3):380-91.
1983: Rumiana Koynova; Boris Tenchov
Effect of ion concentration on phosphatidylethanolamine distribution in mixed vesicles.
Biochimica et biophysica acta 1983;727(2):351-6.