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Tohru Kozasa

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Chemicals & Drugs

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TOP 3
Mark R Nance; Rachel Sterne-Marr; Tohru Kozasa; Barry Kreutz; Valerie M Tesmer; John J G Tesmer
Structural and functional analysis of the regulator of g protein signaling 2-gαq complex.
Xiaoqing Gan; Tohru Kozasa; Stefan Offermanns; Melvin I Simon; Eeva Sommer; Srinivasa Srinivasula; Chen Wang; Jiyong Wang; Dario Alessi; Dianqing Wu
PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12.
Tohru Kozasa; Christina R Chow; Nicole Hajicek; Nobuchika Suzuki
Signalling mechanisms of RhoGTPase regulation by the heterotrimeric G proteins G12 and G13.

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All Publications

2013: Mark R Nance; Rachel Sterne-Marr; Tohru Kozasa; Barry Kreutz; Valerie M Tesmer; John J G Tesmer
Structural and functional analysis of the regulator of g protein signaling 2-gαq complex.
Structure (London, England : 1993) 2013;21(3):438-48.
2012: Xiaoqing Gan; Tohru Kozasa; Stefan Offermanns; Melvin I Simon; Eeva Sommer; Srinivasa Srinivasula; Chen Wang; Jiyong Wang; Dario Alessi; Dianqing Wu
PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12.
Nature cell biology 2012;14(7):686-96.
2011: Tohru Kozasa; Christina R Chow; Nicole Hajicek; Nobuchika Suzuki
Signalling mechanisms of RhoGTPase regulation by the heterotrimeric G proteins G12 and G13.
Journal of biochemistry 2011;150(4):357-69.
2011: Nicole Hajicek; Mutsuko Kukimoto-Niino; Chiemi Mishima-Tsumagari; Christina R Chow; Mikako Shirouzu; Takaho Terada; Maulik Patel; Shigeyuki Yokoyama; Tohru Kozasa
Identification of critical residues in G(alpha)13 for stimulation of p115RhoGEF activity and the structure of the G(alpha)13-p115RhoGEF regulator of G protein signaling homology (RH) domain complex.
The Journal of biological chemistry 2011;286(23):20625-36.
2010: Gary L Waldo; Tiffany K Ricks; Stephanie N Hicks; Matthew L Cheever; Takeharu Kawano; Kazuhito Tsuboi; Xiaoyue Wang; Craig Montell; Tohru Kozasa; John Sondek; T Kendall Harden
Kinetic scaffolding mediated by a phospholipase C-beta and Gq signaling complex.
Science (New York, N.Y.) 2010;330(6006):974-80.
2010: Haixia Gong; Bo Shen; Panagiotis Flevaris; Christina Chow; Stephen C-T Lam; Tatyana Voyno-Yasenetskaya; Tohru Kozasa; Xiaoping Du
G protein subunit Galpha13 binds to integrin alphaIIbbeta3 and mediates integrin "outside-in" signaling.
Science (New York, N.Y.) 2010;327(5963):340-3.
2010: Kristin K Jernigan; Christopher S Cselenyi; Curtis A Thorne; Alison J Hanson; Emilios Tahinci; Nicole Hajicek; William M Oldham; Laura A Lee; Heidi E Hamm; John R Hepler; Tohru Kozasa; Maurine E Linder; Ethan Lee
Gbetagamma activates GSK3 to promote LRP6-mediated beta-catenin transcriptional activity.
Science signaling 2010;3(121):ra37.
2009: Nobuchika Suzuki; Kouhei Tsumoto; Nicole Hajicek; Kenji Daigo; Reiko Tokita; Shiro Minami; Tatsuhiko Kodama; Takao Hamakubo; Tohru Kozasa
Activation of leukemia-associated RhoGEF by Galpha13 with significant conformational rearrangements in the interface.
The Journal of biological chemistry 2009;284(8):5000-9.
2009: Nobuchika Suzuki; Nicole Hajicek; Tohru Kozasa
Regulation and physiological functions of G12/13-mediated signaling pathways.
Neuro-Signals 2009;17(1):55-70.
2008: Yun Zhang; Yu-Hang Chen; Saroja D Bangaru; Linling He; Kathryn Abele; Shihori Tanabe; Tohru Kozasa; Jian Yang
Origin of the voltage dependence of G-protein regulation of P/Q-type Ca2+ channels.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(52):14176-88.
2008: Aruna Shankaranarayanan; David M Thal; Valerie M Tesmer; David Roman; Richard Neubig; Tohru Kozasa; John J G Tesmer
Assembly of high order G alpha q-effector complexes with RGS proteins.
The Journal of biological chemistry 2008;283(50):34923-34.
2008: Ikuo Masuho; Yasumasa Mototani; Yoshinori Sahara; Junko Asami; Shun Nakamura; Tohru Kozasa; Takayoshi Inoue
Dynamic expression patterns of G protein-regulated inducer of neurite outgrowth 1 (GRIN1) and its colocalization with Galphao implicate significant roles of Galphao-GRIN1 signaling in nervous system.
Developmental dynamics : an official publication of the American Association of Anatomists 2008;237(9):2415-29.
2007: Rafael J Rojas; Marielle E Yohe; Svetlana Gershburg; Takeharu Kawano; Tohru Kozasa; John Sondek
Galphaq directly activates p63RhoGEF and Trio via a conserved extension of the Dbl homology-associated pleckstrin homology domain.
The Journal of biological chemistry 2007;282(40):29201-10.
2007: Barry Kreutz; Nicole Hajicek; Douglas M Yau; Susumu Nakamura; Tohru Kozasa
Distinct regions of Galpha13 participate in its regulatory interactions with RGS homology domain-containing RhoGEFs.
Cellular signalling 2007;19(8):1681-9.
2007: Jin-Sheng Huang; Lanlan Dong; Tohru Kozasa; Guy C Le Breton
Signaling through G(alpha)13 switch region I is essential for protease-activated receptor 1-mediated human platelet shape change, aggregation, and secretion.
The Journal of biological chemistry 2007;282(14):10210-22.
2007: Takeharu Kawano; Peng Zhao; Christina V Floreani; Yasuko Nakajima; Tohru Kozasa; Shigehiro Nakajima
Interaction of Galphaq and Kir3, G protein-coupled inwardly rectifying potassium channels.
Molecular pharmacology 2007;71(4):1179-84.
2006: Qi Zhao; Abla M Albsoul-Younes; Peng Zhao; Tohru Kozasa; Yasuko Nakajima; Shigehiro Nakajima
Dominant negative effects of a Gbeta mutant on G-protein coupled inward rectifier K+ channel.
FEBS letters 2006;580(16):3879-82.
2006: Caroline Marty; Tohru Kozasa; Mark T Quinn; Richard D Ye
Activation state-dependent interaction between Galphai and p67phox.
Molecular and cellular biology 2006;26(13):5190-200.
2006: Barry Kreutz; Douglas M Yau; Mark R Nance; Shihori Tanabe; John J G Tesmer; Tohru Kozasa
A new approach to producing functional G alpha subunits yields the activated and deactivated structures of G alpha(12/13) proteins.
Biochemistry 2006;45(1):167-74.
2005: Valerie M Tesmer; Takeharu Kawano; Aruna Shankaranarayanan; Tohru Kozasa; John J G Tesmer
Snapshot of activated G proteins at the membrane: the Galphaq-GRK2-Gbetagamma complex.
Science (New York, N.Y.) 2005;310(5754):1686-90.
2005: T Kino; Tohru Kozasa; George Chrousos
Statin-induced blockade of prenylation alters nucleocytoplasmic shuttling of GTP-binding proteins gamma2 and beta2 and enhances their suppressive effect on glucocorticoid receptor transcriptional activity.
European journal of clinical investigation 2005;35(8):508-13.
2005: Tomoshige Kino; Anatoly Tiulpakov; Takamasa Ichijo; Ly Chheng; Tohru Kozasa; George Chrousos
G protein beta interacts with the glucocorticoid receptor and suppresses its transcriptional activity in the nucleus.
The Journal of cell biology 2005;169(6):885-96.
2005: Motohiro Nishida; Shihori Tanabe; Yoshiko Maruyama; Supachoke Mangmool; Kyoji Urayama; Yuichi Nagamatsu; Shuichi Takagahara; Justin H Turner; Tohru Kozasa; Hiroyuki Kobayashi; Yoji Sato; Toru Kawanishi; Ryuji Inoue; Taku Nagao; Hitoshi Kurose
G alpha 12/13- and reactive oxygen species-dependent activation of c-Jun NH2-terminal kinase and p38 mitogen-activated protein kinase by angiotensin receptor stimulation in rat neonatal cardiomyocytes.
The Journal of biological chemistry 2005;280(18):18434-41.
2005: Maki Koike-Tani; John M Collins; Takeharu Kawano; Peng Zhao; Qi Zhao; Tohru Kozasa; Shigehiro Nakajima; Yasuko Nakajima
Signal transduction pathway for the substance P-induced inhibition of rat Kir3 (GIRK) channel.
The Journal of physiology 2005;564(Pt 2):489-500.
2005: Hiroko Nakata; Tohru Kozasa
Functional characterization of Galphao signaling through G protein-regulated inducer of neurite outgrowth 1.
Molecular pharmacology 2005;67(3):695-702.
2004: Susumu Nakamura; Barry Kreutz; Shihori Tanabe; Nobuchika Suzuki; Tohru Kozasa
Critical role of lysine 204 in switch I region of Galpha13 for regulation of p115RhoGEF and leukemia-associated RhoGEF.
Molecular pharmacology 2004;66(4):1029-34.
2004: Qin Wang; Min Liu; Tohru Kozasa; Jeffrey rothstein; Paul C Sternweis; Richard Neubig
Thrombin and lysophosphatidic acid receptors utilize distinct rhoGEFs in prostate cancer cells.
The Journal of biological chemistry 2004;279(28):28831-4.
2004: Tohru Kozasa
The structure of GRK2-G beta gamma complex: intimate association of G-protein signaling modules.
Trends in pharmacological sciences 2004;25(2):61-3.
2004: Naoyuki Iida; Tohru Kozasa
Identification and biochemical analysis of GRIN1 and GRIN2.
Methods in enzymology 2004;390():475-83.
2004: Shihori Tanabe; Barry Kreutz; Nobuchika Suzuki; Tohru Kozasa
Regulation of RGS-RhoGEFs by Galpha12 and Galpha13 proteins.
Methods in enzymology 2004;390():285-94.
2004: Qin Wang; Min Liu; Tohru Kozasa; Jeffrey D Rothestein; Paul C Sternweis; Richard Neubig
Ribozyme- and siRNA-mediated suppression of RGS-containing RhoGEF proteins.
Methods in enzymology 2004;389():244-65.
2004: Tohru Kozasa; Richard D Ye
Selective inhibition of G protein-mediated pathways using RGS domains.
Methods in molecular biology (Clifton, N.J.) 2004;237():153-67.
2004: Tohru Kozasa
Purification of G protein subunits from Sf9 insect cells using hexahistidine-tagged alpha and beta gamma subunits.
Methods in molecular biology (Clifton, N.J.) 2004;237():21-38.
2003: Douglas M Yau; Nobuhiko Yokoyama; Yoshio Goshima; Zeba K Siddiqui; Shahid S Siddiqui; Tohru Kozasa
Identification and molecular characterization of the G alpha12-Rho guanine nucleotide exchange factor pathway in Caenorhabditis elegans.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(25):14748-53.
2003: Eric N Johnson; Tammy M Seasholtz; Abdul A Waheed; Barry Kreutz; Nobuchika Suzuki; Tohru Kozasa; Teresa L Z Jones; Joan Heller Brown; Kirk M Druey
RGS16 inhibits signalling through the G alpha 13-Rho axis.
Nature cell biology 2003;5(12):1095-103.
2003: Qi Zhao; Takeharu Kawano; Hiroko Nakata; Yasuko Nakajima; Shigehiro Nakajima; Tohru Kozasa
Interaction of G protein beta subunit with inward rectifier K(+) channel Kir3.
Molecular pharmacology 2003;64(5):1085-91.
2003: Michael Holinstat; Dolly Mehta; Tohru Kozasa; Richard D Minshall; Asrar B Malik
Protein kinase Calpha-induced p115RhoGEF phosphorylation signals endothelial cytoskeletal rearrangement.
The Journal of biological chemistry 2003;278(31):28793-8.
2003: Ken Arai; Yoshiko Maruyama; Motohiro Nishida; Shihori Tanabe; Shuichi Takagahara; Tohru Kozasa; Yasuo Mori; Taku Nagao; Hitoshi Kurose
Differential requirement of G alpha12, G alpha13, G alphaq, and G beta gamma for endothelin-1-induced c-Jun NH2-terminal kinase and extracellular signal-regulated kinase activation.
Molecular pharmacology 2003;63(3):478-88.
2003: Hyeseon Cho; Tohru Kozasa; Cecilia Bondjers; Christer Betsholtz; John Kehrl
Pericyte-specific expression of Rgs5: implications for PDGF and EDG receptor signaling during vascular maturation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(3):440-2.
2003: Nobuchika Suzuki; Susumu Nakamura; Hiroyuki Mano; Tohru Kozasa
Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(2):733-8.
2003: Jeanne M Manganello; Jin-Sheng Huang; Tohru Kozasa; Tatyana Voyno-Yasenetskaya; Guy C Le Breton
Protein kinase A-mediated phosphorylation of the Galpha13 switch I region alters the Galphabetagamma13-G protein-coupled receptor complex and inhibits Rho activation.
The Journal of biological chemistry 2003;278(1):124-30.
2002: Yoshiko Maruyama; Motohiro Nishida; Yoshiyuki Sugimoto; Shihori Tanabe; Justin H Turner; Tohru Kozasa; Teiji Wada; Taku Nagao; Hitoshi Kurose
Galpha(12/13) mediates alpha(1)-adrenergic receptor-induced cardiac hypertrophy.
Circulation research 2002;91(10):961-9.
2002: Moulay Driss Rochdi; Valérie Watier; Carole La Madeleine; Hiroko Nakata; Tohru Kozasa; Jean-Luc Parent
Regulation of GTP-binding protein alpha q (Galpha q) signaling by the ezrin-radixin-moesin-binding phosphoprotein-50 (EBP50).
The Journal of biological chemistry 2002;277(43):40751-9.
2002: Clark D Wells; Mu-Ya Liu; Mandy Jackson; Stephen Gutowski; Pamela M Sternweis; Jeffrey rothstein; Tohru Kozasa; Paul C Sternweis
Mechanisms for reversible regulation between G13 and Rho exchange factors.
The Journal of biological chemistry 2002;277(2):1174-81.
2001: Rita Vaiskunaite; Tohru Kozasa; Tatyana Voyno-Yasenetskaya
Interaction between the G alpha subunit of heterotrimeric G(12) protein and Hsp90 is required for G alpha(12) signaling.
The Journal of biological chemistry 2001;276(49):46088-93.
2001: L W Shepard; M Yang; P Xie; Darren Browning; Tatyana Voyno-Yasenetskaya; Tohru Kozasa; Richard D Ye
Constitutive activation of NF-kappa B and secretion of interleukin-8 induced by the G protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus involve G alpha(13) and RhoA.
The Journal of biological chemistry 2001;276(49):45979-87.
2001: Jiaxin Niu; Rita Vaiskunaite; Nobuchika Suzuki; Tohru Kozasa; Daniel W Carr; Nickolai O Dulin; Tatyana Voyno-Yasenetskaya
Interaction of heterotrimeric G13 protein with an A-kinase-anchoring protein 110 (AKAP110) mediates cAMP-independent PKA activation.
Current biology : CB 2001;11(21):1686-90.
2001: Abla M Albsoul-Younes; Pamela M Sternweis; Peng Zhao; Hiroko Nakata; Shigehiro Nakajima; Yasuko Nakajima; Tohru Kozasa
Interaction sites of the G protein beta subunit with brain G protein-coupled inward rectifier K+ channel.
The Journal of biological chemistry 2001;276(16):12712-7.
2001: Tohru Kozasa
Regulation of G protein-mediated signal transduction by RGS proteins.
Life sciences 2001;68(19-20):2309-17.
2000: Hyeseon Cho; Tohru Kozasa; K Takekoshi; J De Gunzburg; John Kehrl
RGS14, a GTPase-activating protein for Gialpha, attenuates Gialpha- and G13alpha-mediated signaling pathways.
Molecular pharmacology 2000;58(3):569-76.
2000: Rita Vaiskunaite; Vyacheslav Adarichev; H Furthmayr; Tohru Kozasa; A Gudkov; Tatyana Voyno-Yasenetskaya
Conformational activation of radixin by G13 protein alpha subunit.
The Journal of biological chemistry 2000;275(34):26206-12.
2000: Chong-Shan Shi; Srikumar Sinnarajah; Hyeseon Cho; Tohru Kozasa; John Kehrl
G13alpha-mediated PYK2 activation. PYK2 is a mediator of G13alpha -induced serum response element-dependent transcription.
The Journal of biological chemistry 2000;275(32):24470-6.
2000: Chantal Moratz; V H Kang; Kirk M Druey; Chong-Shan Shi; Astrid Scheschonka; P M Murphy; Tohru Kozasa; John Kehrl
Regulator of G protein signaling 1 (RGS1) markedly impairs Gi alpha signaling responses of B lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(4):1829-38.
1999: Christopher V Carman; Jean-Luc Parent; Peter W Day; Alexey N Pronin; Pamela M Sternweis; Philip B Wedegaertner; Alfred G Gilman; Jeffrey L Benovic; Tohru Kozasa
Selective regulation of Galpha(q/11) by an RGS domain in the G protein-coupled receptor kinase, GRK2.
The Journal of biological chemistry 1999;274(48):34483-92.
1999: L T Chen; Alfred G Gilman; Tohru Kozasa
A candidate target for G protein action in brain.
The Journal of biological chemistry 1999;274(38):26931-8.
1998: Tohru Kozasa
[Regulation of G protein-mediated signaling pathways by RGS proteins].
Seikagaku. The Journal of Japanese Biochemical Society 1998;70(12):1418-22.
1998: M P Panchenko; K Saxena; Y Li; S Charnecki; Pamela M Sternweis; Temple F Smith; Alfred G Gilman; Tohru Kozasa; Eva J Neer
Sites important for PLCbeta2 activation by the G protein betagamma subunit map to the sides of the beta propeller structure.
The Journal of biological chemistry 1998;273(43):28298-304.
1998: Jin Wang; A Ducret; Yaping Tu; Tohru Kozasa; Ruedi Aebersold; Elliott M Ross
RGSZ1, a Gz-selective RGS protein in brain. Structure, membrane association, regulation by Galphaz phosphorylation, and relationship to a Gz gtpase-activating protein subfamily.
The Journal of biological chemistry 1998;273(40):26014-25.
1998: Matthew J Hart; Xuejun Jiang; Tohru Kozasa; W Roscoe; William D Singer; Alfred G Gilman; Paul C Sternweis; Gideon Bollag
Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13.
Science (New York, N.Y.) 1998;280(5372):2112-4.
1998: Tohru Kozasa; Xuejun Jiang; Matthew J Hart; Pamela M Sternweis; William D Singer; Alfred G Gilman; Gideon Bollag; Paul C Sternweis
p115 RhoGEF, a GTPase activating protein for Galpha12 and Galpha13.
Science (New York, N.Y.) 1998;280(5372):2109-11.
1998: Y Li; Pamela M Sternweis; S Charnecki; Temple F Smith; Alfred G Gilman; Eva J Neer; Tohru Kozasa
Sites for Galpha binding on the G protein beta subunit overlap with sites for regulation of phospholipase Cbeta and adenylyl cyclase.
The Journal of biological chemistry 1998;273(26):16265-72.
1998: H C Lin; Joseph A Duncan; Tohru Kozasa; Alfred G Gilman
Sequestration of the G protein beta gamma subunit complex inhibits receptor-mediated endocytosis.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(9):5057-60.
1997: Koji Takano; Junko Yasufuku-Takano; Tohru Kozasa; Shigehiro Nakajima; Yasuko Nakajima
Different G proteins mediate somatostatin-induced inward rectifier K+ currents in murine brain and endocrine cells.
The Journal of physiology 1997;502 ( Pt 3)():559-67.
1997: Popov Serguei; Kan Yu; Tohru Kozasa; Thomas Wilkie
The regulators of G protein signaling (RGS) domains of RGS4, RGS10, and GAIP retain GTPase activating protein activity in vitro.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(14):7216-20.
1997: JR Hepler; berman david; Alfred G Gilman; Tohru Kozasa
RGS4 and GAIP are GTPase-activating proteins for Gq alpha and block activation of phospholipase C beta by gamma-thio-GTP-Gq alpha.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(2):428-32.
1996: Tohru Kozasa; Y Kaziro; T Ohtsuka; J J Grigg; Shigehiro Nakajima; Yasuko Nakajima
G protein specificity of the muscarine-induced increase in an inward rectifier potassium current in AtT-20 cells.
Neuroscience research 1996;26(3):289-97.
1996: berman david; Tohru Kozasa; Alfred G Gilman
The GTPase-activating protein RGS4 stabilizes the transition state for nucleotide hydrolysis.
The Journal of biological chemistry 1996;271(44):27209-12.
1996: K Takano; J Yasufuku-Takano; Tohru Kozasa; W D Singer; Shigehiro Nakajima; Yasuko Nakajima
Gq/11 and PLC-beta 1 mediate the substance P-induced inhibition of an inward rectifier K+ channel in brain neurons.
Journal of neurophysiology 1996;76(3):2131-6.
1996: Yasuko Nakajima; Shigehiro Nakajima; Tohru Kozasa
Activation of G protein-coupled inward rectifier K+ channels in brain neurons requires association of G protein beta gamma subunits with cell membrane.
FEBS letters 1996;390(2):217-20.
1996: Tohru Kozasa; Alfred G Gilman
Protein kinase C phosphorylates G12 alpha and inhibits its interaction with G beta gamma.
The Journal of biological chemistry 1996;271(21):12562-7.
1996: J J Grigg; Tohru Kozasa; Yasuko Nakajima; Shigehiro Nakajima
Single-channel properties of a G-protein-coupled inward rectifier potassium channel in brain neurons.
Journal of neurophysiology 1996;75(1):318-28.
1995: Tohru Kozasa; Alfred G Gilman
Purification of recombinant G proteins from Sf9 cells by hexahistidine tagging of associated subunits. Characterization of alpha 12 and inhibition of adenylyl cyclase by alpha z.
The Journal of biological chemistry 1995;270(4):1734-41.
1994: John R Hepler; Tohru Kozasa; Alfred G Gilman
Purification of recombinant Gq alpha, G11 alpha, and G16 alpha from Sf9 cells.
Methods in enzymology 1994;237():191-212.
1993: Tohru Kozasa; John R Hepler; A V Smrcka; M I Simon; S G Rhee; Paul C Sternweis; Alfred G Gilman
Purification and characterization of recombinant G16 alpha from Sf9 cells: activation of purified phospholipase C isozymes by G-protein alpha subunits.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(19):9176-80.
1993: John R Hepler; Tohru Kozasa; A V Smrcka; M I Simon; S G Rhee; Paul C Sternweis; Alfred G Gilman
Purification from Sf9 cells and characterization of recombinant Gq alpha and G11 alpha. Activation of purified phospholipase C isozymes by G alpha subunits.
The Journal of biological chemistry 1993;268(19):14367-75.
1991: J L Garibay; Tohru Kozasa; H Itoh; T Tsukamoto; M Matsuoka; Y Kaziro
Analysis by mRNA levels of the expression of six G protein alpha-subunit genes in mammalian cells and tissues.
Biochimica et biophysica acta 1991;1094(2):193-9.
1991: T Tsukamoto; R Toyama; H Itoh; Tohru Kozasa; M Matsuoka; Y Kaziro
Structure of the human gene and two rat cDNAs encoding the alpha chain of GTP-binding regulatory protein Go: two different mRNAs are generated by alternative splicing.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(8):2974-8.
1991: Y Kaziro; H Itoh; Tohru Kozasa; Masato Nakafuku; T Satoh
Structure and function of signal-transducing GTP-binding proteins.
Annual review of biochemistry 1991;60():349-400.
1990: K Nagata; T Satoh; H Itoh; Tohru Kozasa; Yukio Okano; T Doi; Y Kaziro; Yoshinori Nozawa
The ram: a novel low molecular weight GTP-binding protein cDNA from a rat megakaryocyte library.
FEBS letters 1990;275(1-2):29-32.
1988: M Matsuoka; H Itoh; Tohru Kozasa; Y Kaziro
Sequence analysis of cDNA and genomic DNA for a putative pertussis toxin-insensitive guanine nucleotide-binding regulatory protein alpha subunit.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(15):5384-8.
1988: H Itoh; R Toyama; Tohru Kozasa; T Tsukamoto; M Matsuoka; Y Kaziro
Presence of three distinct molecular species of Gi protein alpha subunit. Structure of rat cDNAs and human genomic DNAs.
The Journal of biological chemistry 1988;263(14):6656-64.
1988: Tohru Kozasa; H Itoh; T Tsukamoto; Y Kaziro
Isolation and characterization of the human Gs alpha gene.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(7):2081-5.
1988: Y Kaziro; H Itoh; Tohru Kozasa; R Toyama; T Tsukamoto; M Matsuoka; Masato Nakafuku; Tomoko Obara; T Takagi; R Hernandez
Structures of the genes coding for G-protein alpha subunits from mammalian and yeast cells.
Cold Spring Harbor symposia on quantitative biology 1988;53 Pt 1():209-20.