Username

Password

Forgot Password?

Preview

Sign-in free and Explore the Exciting World of BiomedExperts:

Over 1.500.000 Profiles
More than 1.800 Organizations worldwide
State of the Art Network Visualizations

Manage your own Profile
Locate Experts in your Country/Region
Locate Experts in your 1. and 2. Level Network
Connect to Experts Worldwide

NetworkView

Osamu Kozawa

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Anatomy

Living Beings

Mice

Phenomena

Phosphorylation

Chemicals & Drugs

Concepts & Ideas

Drug Dose-Response Relationship

Physiology

Enzyme Activation

Sign-in to see full Profile

Network (preview)

Co-Publications
Name
84
Matsuno, Hiroyuki
78
Uematsu, Toshihiko
59
Niwa, Masayuki
43
Kato, Kanefusa
41
Takai, Shinji
38
Tokuda, Haruhiko
34
Matsushima-Nishiwaki, Rie
26
Ishisaki, Akira
25
Hanai, Yoshiteru
23
Tokuda, Haruhiko
21
Hirade, Kouseki
18
Akamatsu, Shigeru
15
Dohi, Shuji
15
Hara, Akira
15
Nakajima, Keiichi

Sign-in to see all Coauthors

Publications

TOP 3
Adachi Seiji; Tokuda Haruhiko; Matsushima-Nishiwaki Rie; Kato Kenji; Natsume Hideo; Minamitani Chiho; Mizutani Jun; Otsuka Takanobu; Kozawa Osamu
Involvement of Rho-kinase in prostaglandin E(1)-stimulated VEGF synthesis through stress-activated protein kinase/c-Jun N-terminal kinase in osteoblast-like MC3T3-E1 cells.
Yamaguchi Shinobu; Tanabe Kumiko; Takai Shinji; Matsushima-Nishiwaki Rie; Adachi Seiji; Iida Hiroki; Kozawa Osamu; Dohi Shuji
Involvement of Rho-kinase in tumor necrosis factor-alpha-induced interleukin-6 release from C6 glioma cells.
Doi Tomoaki; Adachi Seiji; Takai Shinji; Matsushima-Nishiwaki Rie; Kato Hisaaki; Enomoto Yukiko; Minamitani Chiho; Otsuka Takanobu; Tokuda Haruhiko; Akamatsu Shigeru; Iwama Toru; Kozawa Osamu; Ogura Shinji
Antithrombin III suppresses ADP-induced platelet granule secretion: inhibition of HSP27 phosphorylation.

Sign-in to see all Publications

Sign in free and see...

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the visualized research activity
of experts around the globe

Sign-in to see more

Geonetwork of Osamu Kozawa (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

Sign-in to see more

All Publications

2009: Adachi Seiji; Tokuda Haruhiko; Matsushima-Nishiwaki Rie; Kato Kenji; Natsume Hideo; Minamitani Chiho; Mizutani Jun; Otsuka Takanobu; Kozawa Osamu
Involvement of Rho-kinase in prostaglandin E(1)-stimulated VEGF synthesis through stress-activated protein kinase/c-Jun N-terminal kinase in osteoblast-like MC3T3-E1 cells.
Prostaglandins & other lipid mediators 2009;90(1-2):1-6.
2009: Yamaguchi Shinobu; Tanabe Kumiko; Takai Shinji; Matsushima-Nishiwaki Rie; Adachi Seiji; Iida Hiroki; Kozawa Osamu; Dohi Shuji
Involvement of Rho-kinase in tumor necrosis factor-alpha-induced interleukin-6 release from C6 glioma cells.
Neurochemistry international 2009;55(6):438-45.
2009: Doi Tomoaki; Adachi Seiji; Takai Shinji; Matsushima-Nishiwaki Rie; Kato Hisaaki; Enomoto Yukiko; Minamitani Chiho; Otsuka Takanobu; Tokuda Haruhiko; Akamatsu Shigeru; Iwama Toru; Kozawa Osamu; Ogura Shinji
Antithrombin III suppresses ADP-induced platelet granule secretion: inhibition of HSP27 phosphorylation.
Archives of biochemistry and biophysics 2009;489(1-2):62-7.
2009: Adachi Seiji; Shimizu Masahito; Shirakami Yohei; Yamauchi Junichi; Natsume Hideo; Matsushima-Nishiwaki Rie; To Satoshi; Weinstein I Bernard; Moriwaki Hisataka; Kozawa Osamu
(-)-Epigallocatechin gallate downregulates EGF receptor via phosphorylation at Ser1046/1047 by p38 MAPK in colon cancer cells.
Carcinogenesis 2009;30(9):1544-52.
2009: Niwa Masayuki; Hara Akira; Taguchi Ayako; Aoki Hitomi; Kozawa Osamu; Mori Hideki
Spatiotemporal expression of Hsp20 and its phosphorylation in hippocampal CA1 pyramidal neurons after transient forebrain ischemia.
Neurological research 2009;31(7):721-7.
2009: Hanai Yoshiteru; Adachi Seiji; Yasuda Ichiro; Takai Shinji; Matsushima-Nishiwaki Rie; Kato Hisaaki; Enomoto Yukiko; Akamatsu Shigeru; Sakakibara Seiko; Ogura Shinji; Iwama Toru; Kozawa Osamu; Tokuda Haruhiko
Collagen-induced p38 MAP kinase activation is a biomarker of platelet hyper-aggregation in patients with diabetes mellitus.
Life sciences 2009;85(9-10):386-94.
2009: Natsume Hideo; Adachi Seiji; Takai Shinji; Tokuda Haruhiko; Matsushima-Nishiwaki Rie; Minamitani Chiho; Yamauchi Junichi; Kato Kanefusa; Mizutani Jun; Kozawa Osamu; Otsuka Takanobu
(-)-Epigallocatechin gallate attenuates the induction of HSP27 stimulated by sphingosine 1-phosphate via suppression of phosphatidylinositol 3-kinase/Akt pathway in osteoblasts.
International journal of molecular medicine 2009;24(2):197-203.
2009: Enomoto Yukiko; Adachi Seiji; Matsushima-Nishiwaki Rie; Niwa Masayuki; Tokuda Haruhiko; Akamatsu Shigeru; Doi Tomoaki; Kato Hisaaki; Yoshimura Shinichi; Ogura Shinji; Iwama Toru; Kozawa Osamu
alphaB-crystallin extracellularly suppresses ADP-induced granule secretion from human platelets.
FEBS letters 2009;583(15):2464-8.
2009: Minamitani Chiho; Otsuka Takanobu; Takai Shinji; Matsushima-Nishiwaki Rie; Adachi Seiji; Hanai Yoshiteru; Mizutani Jun; Tokuda Haruhiko; Kozawa Osamu
Involvement of Rho-kinase in sphingosine 1-phosphate-stimulated HSP27 induction in osteoblasts.
International journal of molecular medicine 2009;24(1):77-82.
2009: Tanabe Kumiko; Nishimura Kazumi; Dohi Shuji; Kozawa Osamu
Mechanisms of interleukin-1beta-induced GDNF release from rat glioma cells.
Brain research 2009;1274():11-20.
2009: Adachi Seiji; Natsume Hideo; Yamauchi Junichi; Matsushima-Nishiwaki Rie; Joe Andrew K; Moriwaki Hisataka; Kozawa Osamu
p38 MAP kinase controls EGF receptor downregulation via phosphorylation at Ser1046/1047.
Cancer letters 2009;277(1):108-13.
2009: Tokuda H; Hosoi T; Hayasaka K; Okamura K; Yoshimi N; Kozawa O
Overexpression of protein kinase C-delta plays a crucial role in interleukin-6-producing pheochromocytoma presenting with acute inflammatory syndrome: a case report.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2009;41(4):333-8.
2009: Yamauchi Junichi; Takai Shinji; Matsushima-Nishiwaki Rie; Adachi Seiji; Minamitani Chiho; Natsume Hideo; Mizutani Jun; Otsuka Takanobu; Takeda Jun; Harada Atsushi; Kozawa Osamu; Tokuda Haruhiko
Tacrolimus but not cyclosporine A enhances FGF-2-induced VEGF release in osteoblasts.
International journal of molecular medicine 2009;23(2):267-72.
2008: Minamitani Chiho; Otsuka Takanobu; Takai Shinji; Matsushima-Nishiwaki Rie; Adachi Seiji; Hanai Yoshiteru; Mizutani Jun; Tokuda Haruhiko; Kozawa Osamu
Involvement of Rho-kinase in prostaglandin F2alpha-stimulated interleukin-6 synthesis via p38 mitogen-activated protein kinase in osteoblasts.
Molecular and cellular endocrinology 2008;291(1-2):27-32.
2008: Tokuda Haruhiko; Takai Shinji; Matsushima-Nishiwaki Rie; Hanai Yoshiteru; Adachi Seiji; Minamitani Chiho; Mizutani Jun; Otsuka Takanobu; Kozawa Osamu
Function of Rho-kinase in prostaglandin D2-induced interleukin-6 synthesis in osteoblasts.
Prostaglandins, leukotrienes, and essential fatty acids 2008;79(1-2):41-6.
2008: Matsushima-Nishiwaki Rie; Takai Shinji; Adachi Seiji; Minamitani Chiho; Yasuda Eisuke; Noda Takahiro; Kato Kanefusa; Toyoda Hidenori; Kaneoka Yuji; Yamaguchi Akihiro; Kumada Takashi; Kozawa Osamu
Phosphorylated heat shock protein 27 represses growth of hepatocellular carcinoma via inhibition of extracellular signal-regulated kinase.
The Journal of biological chemistry 2008;283(27):18852-60.
2008: Kato Hisaaki; Takai Shinji; Matsushima-Nishiwaki Rie; Adachi Seiji; Minamitani Chiho; Otsuka Takanobu; Tokuda Haruhiko; Akamatsu Shigeru; Doi Tomoaki; Ogura Shinji; Kozawa Osamu
HSP27 phosphorylation is correlated with ADP-induced platelet granule secretion.
Archives of biochemistry and biophysics 2008;475(1):80-6.
2008: Tanabe Kumiko; Takai Shinji; Matsushima-Nishiwaki Rie; Kato Kanefusa; Dohi Shuji; Kozawa Osamu
Alpha2 adrenoreceptor agonist regulates protein kinase C-induced heat shock protein 27 phosphorylation in C6 glioma cells.
Journal of neurochemistry 2008;106(2):519-28.
2008: Hayashi Kana; Takai Shinji; Matsushima-Nishiwaki Rie; Hanai Yoshiteru; Kato Kanefusa; Tokuda Haruhiko; Kozawa Osamu
(-)-Epigallocatechin gallate reduces transforming growth factor beta-stimulated HSP27 induction through the suppression of stress-activated protein kinase/c-Jun N-terminal kinase in osteoblasts.
Life sciences 2008;82(19-20):1012-7.
2008: Takai S; Hanai Y; Matsushima-Nishiwaki R; Minamitani C; Otsuka T; Tokuda H; Kozawa O
P70 S6 kinase negatively regulates fibroblast growth factor 2-stimulated interleukin-6 synthesis in osteoblasts: function at a point downstream from protein kinase C.
The Journal of endocrinology 2008;197(1):131-7.
2008: Takai Shinji; Matsushima-Nishiwaki Rie; Adachi Seiji; Natsume Hideo; Minamitani Chiho; Mizutani Jun; Otsuka Takanobu; Tokuda Haruhiko; Kozawa Osamu
(-)-Epigallocatechin gallate reduces platelet-derived growth factor-BB-stimulated interleukin-6 synthesis in osteoblasts: suppression of SAPK/JNK.
Mediators of inflammation 2008;2008():291808.
2008: Minamitani Chiho; Takai Shinji; Matsushima-Nishiwaki Rie; Hanai Yoshiteru; Otuka Takanobu; Kozawa Osamu; Tokuda Haruhiko
Raloxifene-induced acceleration of platelet aggregation.
Internal medicine (Tokyo, Japan) 2008;47(17):1523-8.
2008: Tokuda Haruhiko; Takai Shinji; Hanai Yoshiteru; Harada Atsushi; Matsushima-Nishiwaki Rie; Kato Hisaaki; Ogura Shinji; Kozawa Osamu
Potentiation by platelet-derived growth factor-BB of FGF-2-stimulated VEGF release in osteoblasts.
Journal of bone and mineral metabolism 2008;26(4):335-41.
2007: Tokuda Haruhiko; Hanai Yoshiteru; Matsushima-Nishiwaki Rie; Yamauchi Junichi; Doi Tomoaki; Harada Atsushi; Takai Shinji; Kozawa Osamu
Rho-kinase regulates endothelin-1-stimulated IL-6 synthesis via p38 MAP kinase in osteoblasts.
Biochemical and biophysical research communications 2007;362(4):799-804.
2007: Tokuda Haruhiko; Takai Shinji; Hanai Yoshiteru; Harada Atsushi; Matsushima-Nishiwaki Rie; Akamatsu Shigeru; Ohta Toshiki; Kozawa Osamu
Platelet-derived growth factor-BB amplifies PGF2alpha-stimulated VEGF synthesis in osteoblasts: function of phosphatidylinositol 3-kinase.
Prostaglandins, leukotrienes, and essential fatty acids 2007;77(3-4):187-93.
2007: Yamauchi Junichi; Takai Shinji; Matsushima-Nishiwaki Rie; Hanai Yoshiteru; Doi Tomoaki; Kato Hisaaki; Ogura Shinji; Kato Kanefusa; Tokuda Haruhiko; Kozawa Osamu
(-)-epigallocatechin gallate inhibits prostaglandin D2-stimulated HSP27 induction via suppression of the p44/p42 MAP kinase pathway in osteoblasts.
Prostaglandins, leukotrienes, and essential fatty acids 2007;77(3-4):173-9.
2007: Takai Shinji; Matsushima-Nishiwaki Rie; Tokuda Haruhiko; Yasuda Eisuke; Toyoda Hidenori; Kaneoka Yuji; Yamaguchi Akihiro; Kumada Takashi; Kozawa Osamu
Protein kinase C delta regulates the phosphorylation of heat shock protein 27 in human hepatocellular carcinoma.
Life sciences 2007;81(7):585-91.
2007: Noda Takahiro; Kumada Takashi; Takai Shinji; Matsushima-Nishiwaki Rie; Yoshimi Naoki; Yasuda Eisuke; Kato Kanefusa; Toyoda Hidenori; Kaneoka Yuji; Yamaguchi Akihiro; Kozawa Osamu
Expression levels of heat shock protein 20 decrease in parallel with tumor progression in patients with hepatocellular carcinoma.
Oncology reports 2007;17(6):1309-14.
2007: Takai Shinji; Nagaki Masahito; Imao Motohiro; Kimura Kiminori; Kozawa Osamu; Moriwaki Hisataka
Intrinsic resistance to TNF-alpha-induced hepatocyte apoptosis in ICR mice correlates with expression of a short form of c-FLIP.
Laboratory investigation; a journal of technical methods and pathology 2007;87(6):572-81.
2007: Takai Shinji; Tokuda Haruhiko; Hanai Yoshiteru; Kozawa Osamu
Limitation by p70 S6 kinase of platelet-derived growth factor-BB-induced interleukin 6 synthesis in osteoblast-like MC3T3-E1 cells.
Metabolism: clinical and experimental 2007;56(4):476-83.
2007: Tokuda Haruhiko; Takai Shinji; Hanai Yoshiteru; Matsushima-Nishiwaki Rie; Hosoi Takayuki; Harada Atsushi; Ohta Toshiki; Kozawa Osamu
(-)-Epigallocatechin gallate suppresses endothelin-1-induced interleukin-6 synthesis in osteoblasts: inhibition of p44/p42 MAP kinase activation.
FEBS letters 2007;581(7):1311-6.
2007: Tokuda Haruhiko; Takai Shinji; Matsushima-Nishiwaki Rie; Akamatsu Shigeru; Hanai Yoshiteru; Hosoi Takayuki; Harada Atsushi; Ohta Toshiki; Kozawa Osamu
(--)-epigallocatechin gallate enhances prostaglandin F2alpha-induced VEGF synthesis via upregulating SAPK/JNK activation in osteoblasts.
Journal of cellular biochemistry 2007;100(5):1146-53.
2007: Takai Shinji; Tokuda Haruhiko; Hanai Yoshiteru; Kozawa Osamu
Activation of phosphatidylinositol 3-kinase/Akt limits FGF-2-induced VEGF release in osteoblasts.
Molecular and cellular endocrinology 2007;267(1-2):46-54.
2007: Takai Shinji; Tokuda Haruhiko; Hanai Yoshiteru; Harada Atsushi; Yasuda Eisuke; Matsushima-Nishiwaki Rie; Kato Hisaaki; Ogura Shinji; Ohta Toshiki; Kozawa Osamu
Negative regulation by p70 S6 kinase of FGF-2-stimulated VEGF release through stress-activated protein kinase/c-Jun N-terminal kinase in osteoblasts.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2007;22(3):337-46.
2006: Niwa Masayuki; Hotta Koichi; Hara Akira; Hirade Kouseki; Ito Hidenori; Kato Kanefusa; Kozawa Osamu
TNF-alpha decreases hsp 27 in human blood mononuclear cells: involvement of protein kinase c.
Life sciences 2006;80(3):181-6.
2006: Hanai Yoshiteru; Tokuda Haruhiko; Yasuda Eisuke; Noda Takahiro; Ohta Toshiki; Takai Shinji; Kozawa Osamu
Up-regulation by zinc of FGF-2-induced VEGF release through enhancing p44/p42 MAP kinase activation in osteoblasts.
Life sciences 2006;80(3):230-4.
2006: Hanai Yoshiteru; Tokuda Haruhiko; Ohta Toshiki; Matsushima-Nishiwaki Rie; Takai Shinji; Kozawa Osamu
Phosphatidylinositol 3-kinase/Akt auto-regulates PDGF-BB-stimulated interleukin-6 synthesis in osteoblasts.
Journal of cellular biochemistry 2006;99(6):1564-71.
2006: Takai S; Tokuda H; Hanai Y; Kozawa O
Phosphatidylinositol 3-kinase/Akt plays a part in tumor necrosis factor-alpha-induced interleukin-6 synthesis in osteoblasts.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2006;38(9):563-9.
2006: Takai Shinji; Akamatsu Shigeru; Yasuda Eisuke; Kozawa Osamu
[Low-molecular-weight HSP and vasopressin in vascular smooth muscle]
Nippon yakurigaku zasshi. Folia pharmacologica Japonica 2006;128(3):141-5.
2006: Hara Akira; Niwa Masayuki; Aoki Hitomi; Kumada Masako; Kunisada Takahiro; Oyama Takeru; Yamamoto Tetsuya; Kozawa Osamu; Mori Hideki
A new model of retinal photoreceptor cell degeneration induced by a chemical hypoxia-mimicking agent, cobalt chloride.
Brain research 2006;1109(1):192-200.
2006: Tanabe Kumiko; Tokuda Haruhiko; Takai Shinji; Matsushima-Nishiwaki Rie; Hanai Yoshiteru; Hirade Kouseki; Katagiri Yoshihiro; Dohi Shuji; Kozawa Osamu
Modulation by the steroid/thyroid hormone superfamily of TGF-beta-stimulated VEGF release from vascular smooth muscle cells.
Journal of cellular biochemistry 2006;99(1):187-95.
2006: Takai Shinji; Tokuda Haruhiko; Yoshida Minoru; Yasuda Eisuke; Matsushima-Nishiwaki Rie; Harada Atsushi; Kato Kanefusa; Kozawa Osamu
Prostaglandin D2 induces the phosphorylation of HSP27 in osteoblasts: function of the MAP kinase superfamily.
Prostaglandins, leukotrienes, and essential fatty acids 2006;75(2):61-7.
2006: Nakajima Keiichi; Suga Hidetaka; Matsuno Hiroyuki; Ishisaki Akira; Hirade Kouseki; Kozawa Osamu
Differential roles of MAP kinases in atorvastatin-induced VEGF release in cardiac myocytes.
Life sciences 2006;79(12):1214-20.
2006: Takai Shinji; Tokuda Haruhiko; Matsushima-Nishiwaki Rie; Hanai Yoshiteru; Kato Kanefusa; Kozawa Osamu
Phosphatidylinositol 3-kinase/Akt plays a role in sphingosine 1-phosphate-stimulated HSP27 induction in osteoblasts.
Journal of cellular biochemistry 2006;98(5):1249-56.
2006: Hanai Yoshiteru; Tokuda Haruhiko; Ishisaki Akira; Matsushima-Nishiwaki Rie; Nakamura Norimi; Yoshida Minoru; Takai Shinji; Ohta Toshiki; Kozawa Osamu
Involvement of p44/p42 MAP kinase in insulin-like growth factor-I-induced alkaline phosphatase activity in osteoblast-like-MC3T3-E1 cells.
Molecular and cellular endocrinology 2006;251(1-2):42-8.
2006: Hara Akira; Niwa Masayuki; Kumada Masako; Aoki Hitomi; Kunisada Takahiro; Oyama Takeru; Yamamoto Tetsuya; Kozawa Osamu; Mori Hideki
Intraocular injection of folate antagonist methotrexate induces neuronal differentiation of embryonic stem cells transplanted in the adult mouse retina.
Brain research 2006;1085(1):33-42.
2006: Hanai Y; Tokuda H; Takai S; Harada A; Ohta T; Kozawa O
Minodronate suppresses prostaglandin F2alpha-induced vascular endothelial growth factor synthesis in osteoblasts.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2006;38(3):152-8.
2005: Yasuda Eisuke; Kumada Takashi; Takai Shinji; Ishisaki Akira; Noda Takahiro; Matsushima-Nishiwaki Rie; Yoshimi Naoki; Kato Kanefusa; Toyoda Hidenori; Kaneoka Yuji; Yamaguchi Akihiro; Kozawa Osamu
Attenuated phosphorylation of heat shock protein 27 correlates with tumor progression in patients with hepatocellular carcinoma.
Biochemical and biophysical research communications 2005;337(1):337-42.
2005: Tanabe Kumiko; Akamatsu Shigeru; Suga Hidetaka; Takai Shinji; Kato Kanefusa; Dohi Shuji; Kozawa Osamu
Midazolam suppresses thrombin-induced heat shock protein 27 phosphorylation through inhibition of p38 mitogen-activated protein kinase in cardiac myocytes.
Journal of cellular biochemistry 2005;96(1):56-64.
2005: Shu En; Matsuno Hiroyuki; Akamastu Shigeru; Kanno Yosuke; Suga Hidetaka; Nakajima Keiichi; Ishisaki Akira; Takai Shinji; Kato Kanefusa; Kitajima Yasuo; Kozawa Osamu
alphaB-crystallin is phosphorylated during myocardial infarction: involvement of platelet-derived growth factor-BB.
Archives of biochemistry and biophysics 2005;438(2):111-8.
2005: Suga Hidetaka; Nakajima Keiichi; Shu En; Kanno Yosuke; Hirade Kouseki; Ishisaki Akira; Matsuno Hiroyuki; Tanabe Kumiko; Takai Shinji; Akamatsu Shigeru; Kato Kanefusa; Oiso Yutaka; Kozawa Osamu
Possible involvement of phosphatidylinositol 3-kinase/Akt signal pathway in vasopressin-induced HSP27 phosphorylation in aortic smooth muscle A10 cells.
Archives of biochemistry and biophysics 2005;438(2):137-45.
2005: Noda T; Tokuda H; Yoshida M; Yasuda E; Hanai Y; Takai S; Kozawa O
Possible involvement of phosphatidylinositol 3-kinase/Akt pathway in insulin-like growth factor-I-induced alkaline phosphatase activity in osteoblasts.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2005;37(5):270-4.
2005: Yoshida Minoru; Tokuda Haruhiko; Ishisaki Akira; Kanno Yosuke; Harada Atsushi; Shimuzu Katsuji; Kozawa Osamu
Tiludronate inhibits prostaglandin F2alpha-induced vascular endothelial growth factor synthesis in osteoblasts.
Molecular and cellular endocrinology 2005;236(1-2):59-66.
2005: Yoshida Minoru; Kanno Yosuke; Ishisaki Akira; Tokuda Haruhiko; Hirade Kouseki; Nakajima Keiichi; Katagiri Yoshihiro; Shimizu Katsuji; Kozawa Osamu
Methotrexate suppresses inflammatory agonist induced interleukin 6 synthesis in osteoblasts.
The Journal of rheumatology 2005;32(5):787-95.
2005: Nakajima Keiichi; Hirade Kouseki; Ishisaki Akira; Matsuno Hiroyuki; Suga Hidetaka; Kanno Yosuke; Shu En; Kitajima Yasuo; Katagiri Yoshihiro; Kozawa Osamu
Akt regulates thrombin-induced HSP27 phosphorylation in aortic smooth muscle cells: function at a point downstream from p38 MAP kinase.
Life sciences 2005;77(1):96-107.
2005: Kumada Masako; Niwa Masayuki; Hara Akira; Matsuno Hiroyuki; Mori Hideki; Ueshima Shigeru; Matsuo Osamu; Yamamoto Tetsuya; Kozawa Osamu
Tissue type plasminogen activator facilitates NMDA-receptor-mediated retinal apoptosis through an independent fibrinolytic cascade.
Investigative ophthalmology & visual science 2005;46(4):1504-7.
2005: Kanno Y; Ishisaki A; Yoshida M; Tokuda H; Numata O; Kozawa O
SAPK/JNK plays a role in transforming growth factor-beta-induced VEGF synthesis in osteoblasts.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2005;37(3):140-5.
2005: Yasuda Eisuke; Tokuda Haruhiko; Ishisaki Akira; Hirade Kouseki; Kanno Yosuke; Hanai Yoshiteru; Nakamura Norimi; Noda Takahiro; Katagiri Yoshihiro; Kozawa Osamu
PPAR-gamma ligands up-regulate basic fibroblast growth factor-induced VEGF release through amplifying SAPK/JNK activation in osteoblasts.
Biochemical and biophysical research communications 2005;328(1):137-43.
2005: Hirade Kouseki; Tanabe Kumiko; Niwa Masayuki; Ishisaki Akira; Nakajima Keiichi; Nakamura Mitsuhiro; Sugiyama Tadashi; Katagiri Yoshihiro; Kato Kanefusa; Kozawa Osamu
Adenylyl cyclase-cAMP system inhibits thrombin-induced HSP27 in vascular smooth muscle cells.
Journal of cellular biochemistry 2005;94(3):573-84.
2005: Kanno Yosuke; Ishisaki Akira; Yoshida Minoru; Nakajima Keiichi; Tokuda Haruhiko; Numata Osamu; Kozawa Osamu
Adenylyl cyclase-cAMP system inhibits thyroid hormone-stimulated osteocalcin synthesis in osteoblasts.
Molecular and cellular endocrinology 2005;229(1-2):75-82.
2004: Yoshida Minoru; Niwa Masayuki; Ishisaki Akira; Hirade Kouseki; Ito Hidenori; Shimizu Katsuji; Kato Kanefusa; Kozawa Osamu
Methotrexate enhances prostaglandin D2-stimulated heat shock protein 27 induction in osteoblasts.
Prostaglandins, leukotrienes, and essential fatty acids 2004;71(6):351-62.
2004: Kumada Masako; Niwa Masayuki; Wang Xiaodan; Matsuno Hiroyuki; Hara Akira; Mori Hideki; Matsuo Osamu; Yamamoto Tetsuya; Kozawa Osamu
Endogenous tissue type plasminogen activator facilitates NMDA-induced retinal damage.
Toxicology and applied pharmacology 2004;200(1):48-53.
2004: Tanabe Kumiko; Hirade Kouseki; Ishisaki Akira; Shu En; Suga Hidetaka; Kitajima Yasuo; Katagiri Yoshihiro; Dohi Shuji; Kozawa Osamu
Possible involvement of p44/p42 MAP kinase in retinoic acid-stimulated vascular endothelial growth factor release in aortic smooth muscle cells.
Atherosclerosis 2004;175(2):245-51.
2004: Akamatsu Shigeru; Nakajima Keiichi; Ishisaki Akira; Matsuno Hiroyuki; Tanabe Kumiko; Takei Mariko; Takenaka Motoki; Hirade Kouseki; Yoshimi Naoki; Suga Hidetaka; Oiso Yutaka; Kato Kanefusa; Kozawa Osamu
Vasopressin phosphorylates HSP27 in aortic smooth muscle cells.
Journal of cellular biochemistry 2004;92(6):1203-11.
2004: Matsuno Hiroyuki; Ishisaki Akira; Nakajima Keiichi; Kozawa Osamu
Effect of a synthetic matrix metalloproteinase inhibitor (ONO-4817) on neointima formation in hypercholesterolemic hamsters.
Journal of cardiovascular pharmacology 2004;44(1):57-65.
2004: Kanno Y; Tokuda H; Nakajima K; Ishisaki A; Shibata T; Numata O; Kozawa O
Involvement of SAPK/JNK in prostaglandin E(1)-induced VEGF synthesis in osteoblast-like cells.
Molecular and cellular endocrinology 2004;220(1-2):89-95.
2004: Niwa Masayuki; Hotta Koichi; Kanamori Yutaka; Kumada Masako; Hirota Masao; Kozawa Osamu; Fujimoto Sadaki
p38 MAPK associated with stereoselective priming by grepafloxacin on O2- production in neutrophils.
Free radical biology & medicine 2004;36(10):1259-69.
2004: Hara Akira; Niwa Masayuki; Kumada Masako; Kitaori Nami; Yamamoto Tetsuya; Kozawa Osamu; Mori Hideki
Fragmented DNA transport in dendrites of retinal neurons during apoptotic cell death.
Brain research 2004;1007(1-2):183-7.
2004: Tokuda H; Niwa M; Ishisaki A; Nakajima K; Ito H; Kato K; Kozawa O
Involvement of stress-activated protein kinase (SAPK)/c-Jun N-terminal kinase (JNK) in prostaglandin F2alpha-induced heat shock protein 27 in osteoblasts.
Prostaglandins, leukotrienes, and essential fatty acids 2004;70(5):441-7.
2004: Tokuda Haruhiko; Kanno Yosuke; Ishisaki Akira; Takenaka Motoki; Harada Atsushi; Kozawa Osamu
Interleukin (IL)-17 enhances tumor necrosis factor-alpha-stimulated IL-6 synthesis via p38 mitogen-activated protein kinase in osteoblasts.
Journal of cellular biochemistry 2004;91(5):1053-61.
2004: Matsuno Hiroyuki; Takei Mariko; Hayashi Hideharu; Nakajima Keiichi; Ishisaki Akira; Kozawa Osamu
Simvastatin enhances the regeneration of endothelial cells via VEGF secretion in injured arteries.
Journal of cardiovascular pharmacology 2004;43(3):333-40.
2004: Hara Akira; Niwa Masayuki; Kunisada Takahiro; Yoshimura Naoko; Katayama Masaki; Kozawa Osamu; Mori Hideki
Embryonic stem cells are capable of generating a neuronal network in the adult mouse retina.
Brain research 2004;999(2):216-21.
2004: Ishisaki A; Tokuda H; Yoshida M; Hirade K; Kunieda K; Hatakeyama D; Shibata T; Kozawa O
Activation of p38 mitogen-activated protein kinase mediates thyroid hormone-stimulated osteocalcin synthesis in osteoblasts.
Molecular and cellular endocrinology 2004;214(1-2):189-95.
2004: Takenaka Motoki; Matsuno Hiroyuki; Ishisaki Akira; Nakajima Keiichi; Hirade Kouseki; Takei Mariko; Yasuda Eisuke; Akamatsu Shigeru; Yoshimi Naoki; Kato Kanefusa; Kozawa Osamu
Platelet-derived growth factor-BB phosphorylates heat shock protein 27 in cardiac myocytes.
Journal of cellular biochemistry 2004;91(2):316-24.
2003: Matsuno H; Ishisaki A; Nakajima K; Kato K; Kozawa O
A peptide isolated from alpha B-crystallin is a novel and potent inhibitor of platelet aggregation via dual prevention of PAR-1 and GPIb/V/IX.
Journal of thrombosis and haemostasis : JTH 2003;1(12):2636-42.
2003: Matsuno Hiroyuki; Ishisaki Akira; Nakajima Keiichi; Okada Kiyotaka; Ueshima Shigeru; Matsuo Osamu; Kozawa Osamu
Lack of alpha 2-antiplasmin promotes re-endothelialization via over-release of VEGF after vascular injury in mice.
Blood 2003;102(10):3621-8.
2003: Tokuda H; Niwa M; Ito H; Oiso Y; Kato K; Kozawa O
Involvement of stress-activated protein kinase/c-Jun N-terminal kinase in endothelin-1-induced heat shock protein 27 in osteoblasts.
European journal of endocrinology / European Federation of Endocrine Societies 2003;149(3):239-45.
2003: Matsuno H; Okada K; Ueshima S; Matsuo O; Kozawa O
Alpha2-antiplasmin plays a significant role in acute pulmonary embolism.
Journal of thrombosis and haemostasis : JTH 2003;1(8):1734-9.
2003: Shu En; Matsuno Hiroyuki; Ishisaki Akira; Kitajima Yasuo; Kozawa Osamu
Lack of plasminogen activator inhibitor-1 enhances the preventive effect of DX-9065a, a selective factor Xa inhibitor, on venous thrombus and acute pulmonary embolism in mice.
Pathophysiology of haemostasis and thrombosis 2003;33(4):206-13.
2003: Tokuda Haruhiko; Hatakeyama Daijiro; Akamatsu Shigeru; Tanabe Kumiko; Yoshida Minoru; Shibata Toshiyuki; Kozawa Osamu
Involvement of MAP kinases in TGF-beta-stimulated vascular endothelial growth factor synthesis in osteoblasts.
Archives of biochemistry and biophysics 2003;415(1):117-25.
2003: Wang Xiaodan; Tokuda Haruhiko; Hatakeyama Daijiro; Hirade Kouseki; Niwa Masayuki; Ito Hidenori; Kato Kanefusa; Kozawa Osamu
Mechanism of simvastatin on induction of heat shock protein in osteoblasts.
Archives of biochemistry and biophysics 2003;415(1):6-13.
2003: Tokuda Haruhiko; Hatakeyama Daijiro; Shibata Toshiyuki; Akamatsu Shigeru; Oiso Yutaka; Kozawa Osamu
p38 MAP kinase regulates BMP-4-stimulated VEGF synthesis via p70 S6 kinase in osteoblasts.
American journal of physiology. Endocrinology and metabolism 2003;284(6):E1202-9.
2003: Tanabe Kumiko; Dohi Shuji; Matsuno Hiroyuki; Hirade Kouseki; Kozawa Osamu
Midazolam stimulates vascular endothelial growth factor release in aortic smooth muscle cells: role of the mitogen-activated protein kinase superfamily.
Anesthesiology 2003;98(5):1147-54.
2003: Tokuda Haruhiko; Harada Atsushi; Hirade Kouseki; Matsuno Hiroyuki; Ito Hidenori; Kato Kanefusa; Oiso Yutaka; Kozawa Osamu
Incadronate amplifies prostaglandin F2 alpha-induced vascular endothelial growth factor synthesis in osteoblasts. Enhancement of MAPK activity.
The Journal of biological chemistry 2003;278(21):18930-7.
2003: Tokuda H; Hirade K; Wang X; Oiso Y; Kozawa O
Involvement of SAPK/JNK in basic fibroblast growth factor-induced vascular endothelial growth factor release in osteoblasts.
The Journal of endocrinology 2003;177(1):101-7.
2003: Niwa Masayuki; Hotta Koichi; Kanamori Yutaka; Hatakeyama Daijiro; Hirade Kouseki; Katayama Masaki; Hara Akira; Mori Hideki; Ito Hidenori; Kato Kanefusa; Matsuno Hiroyuki; Uematsu Toshihiko; Kozawa Osamu
Involvement of p38 mitogen-activated protein kinase in heat shock protein 27 induction in human neutrophils.
European journal of pharmacology 2003;466(3):245-53.
2003: Tokuda H; Kato K; Oiso Y; Kozawa O
Contrasting effects of triiodothyronine on heat shock protein 27 induction and vascular endothelial growth factor synthesis stimulated by TGF-beta in osteoblasts.
Molecular and cellular endocrinology 2003;201(1-2):33-8.
2003: Matsuno Hiroyuki; Kozawa Osamu
[Novel physiological roles of low molecular weight HSPs]
Nippon yakurigaku zasshi. Folia pharmacologica Japonica 2003;121(1):21-5.
2003: Takenaka Motoki; Hirade Kouseki; Tanabe Kumiko; Akamatsu Shigeru; Dohi Shuji; Matsuno Hiroyuki; Kozawa Osamu
Simvastatin stimulates VEGF release via p44/p42 MAP kinase in vascular smooth muscle cells.
Biochemical and biophysical research communications 2003;301(1):198-203.
2002: Takei Mariko; Matsuno Hiroyuki; Okada Kiyotaka; Ueshima Shigeru; Matsuo Osamu; Kozawa Osamu
Lack of alpha 2-antiplasmin enhances ADP induced platelet micro-aggregation through the presence of excess active plasmin in mice.
Journal of thrombosis and thrombolysis 2002;14(3):205-11.
2002: Kozawa Osamu; Hatakeyama Daijiro; Tokuda Haruhiko; Oiso Yutaka; Matsuno Hiroyuki; Uematsu Toshihiko
Sphingomyelinase amplifies BMP-4-induced osteocalcin synthesis in osteoblasts: role of ceramide.
Cellular signalling 2002;14(12):999-1004.
2002: Kozawa Osamu; Matsuno Hiroyuki; Niwa Masayuki; Hatakeyama Daijiro; Oiso Yutaka; Kato Kanefusa; Uematsu Toshihiko
HSP20, low-molecular-weight heat shock-related protein, acts extracellularly as a regulator of platelet functions: a novel defense mechanism.
Life sciences 2002;72(2):113-24.
2002: Wang Xiaodan; Niwa Masayuki; Hara Akira; Matsuno Hiroyuki; Kawase Kazuhide; Kozawa Osamu; Mow Hideki; Uematsu Toshihiko
Neuronal degradation in mouse retina after a transient ischemia and protective effect of hypothermia.
Neurological research 2002;24(7):730-5.
2002: Niwa Masayuki; Kanamori Yutaka; Hotta Koichi; Matsuno Hiroyuki; Kozawa Osamu; Fujimoto Sadaki; Uematsu Toshihiko
Priming by grepafloxacin on respiratory burst of human neutrophils: its possible mechanism.
The Journal of antimicrobial chemotherapy 2002;50(4):469-78.
2002: Matsuno Hiroyuki; Kozawa Osamu; Yoshimi Naoki; Akamatsu Shigeru; Hara Akira; Mori Hideki; Okada Kiyotaka; Ueshima Shigeru; Matsuo Osamu; Uematsu Toshihiko
Lack of alpha2-antiplasmin promotes pulmonary heart failure via overrelease of VEGF after acute myocardial infarction.
Blood 2002;100(7):2487-93.
2002: Hirade Kouseki; Kozawa Osamu; Tanabe Kumiko; Niwa Masayuki; Matsuno Hiroyuki; Oiso Yutaka; Akamatsu Shigeru; Ito Hidenori; Kato Kanefusa; Katagiri Yoshihiro; Uematsu Toshihiko
Thrombin stimulates dissociation and induction of HSP27 via p38 MAPK in vascular smooth muscle cells.
American journal of physiology. Heart and circulatory physiology 2002;283(3):H941-8.
2002: Matsuno Hiroyuki; Uematsu Toshihiko; Niwa Masayuki; Kozawa Osamu; Nagashima Satoru; Kohno Ken-Ichi; Kato Hiroki; Kawabata Yoshihiro; Yoshida Yasuhisa; Kanamaru Mitsutaka
Pharmacokinetic and pharmacodynamic properties of a new thromboxane receptor antagonist (Z-335) after single and multiple oral administrations to healthy volunteers.
Journal of clinical pharmacology 2002;42(7):782-90.
2002: Hotta Koichi; Niwa Masayuki; Hirota Masao; Kanamori Yutaka; Matsuno Hiroyuki; Kozawa Osamu; Otsuka Takanobu; Matsui Nobuo; Uematsu Toshihiko
Regulation of fluoroquinolone uptake by human neutrophils: involvement of mitogen-activated protein kinase.
The Journal of antimicrobial chemotherapy 2002;49(6):953-9.
2002: Tokuda H; Kozawa O; Uematsu T
Interleukin (IL)-17 enhances prostaglandin F(2 alpha)-stimulated IL-6 synthesis in osteoblasts.
Prostaglandins, leukotrienes, and essential fatty acids 2002;66(4):427-33.
2002: Kozawa Osamu; Otsuka Takanobu; Uematsu Toshihiko
Leukemia inhibitory factor enhances bFGF-induced IL-6 synthesis in osteoblasts: involvement of JAK2/STAT3.
Cellular signalling 2002;14(4):311-5.
2002: Hatakeyama Daijiro; Kozawa Osamu; Niwa Masayuki; Matsuno Hiroyuki; Ito Hidenori; Kato Kanefusa; Tatematsu Norichika; Shibata Toshiyuki; Uematsu Toshihiko
Upregulation by retinoic acid of transforming growth factor-beta-stimulated heat shock protein 27 induction in osteoblasts: involvement of mitogen-activated protein kinases.
Biochimica et biophysica acta 2002;1589(1):15-30.
2002: Kozawa Osamu; Tokuda Haruhiko
[Heat shock protein 27 in osteoblasts]
Nippon yakurigaku zasshi. Folia pharmacologica Japonica 2002;119(2):89-94.
2002: Tokuda H; Kozawa O; Niwa M; Matsuno H; Kato K; Uematsu T
Mechanism of prostaglandin E2-stimulated heat shock protein 27 induction in osteoblast-like MC3T3-E1 cells.
The Journal of endocrinology 2002;172(2):271-81.
2002: Yamamoto Takuji; Kozawa Osamu; Tanabe Kumiko; Akamatsu Shigeru; Matsuno Hiroyuki; Dohi Shuji; Hirose Hajime; Uematsu Toshihiko
1,25-dihydroxyvitamin D3 stimulates vascular endothelial growth factor release in aortic smooth muscle cells: role of p38 mitogen-activated protein kinase.
Archives of biochemistry and biophysics 2002;398(1):1-6.
2002: Matsuno Hiroyuki; Kozawa Osamu; Okada Kiyotaka; Ueshima Shigeru; Matsuo Osamu; Uematsu Toshihiko
Inhibitors of fibrinolytic components play different roles in the formation and removal of arterial thrombus in mice.
Journal of cardiovascular pharmacology 2002;39(2):278-86.
2002: Matsuno Hiroyuki; Kozawa Osamu; Okada Kiyotaka; Ueshima Shigeru; Matsuo Osamu; Uematsu Toshihiko
Plasmin generation plays different roles in the formation and removal of arterial and venous thrombus in mice.
Thrombosis and haemostasis 2002;87(1):98-104.
2002: Wang Xiaodan; Tokuda Haruhiko; Hirade Kouseki; Kozawa Osamu
Stress-activated protein kinase/c-Jun N-terminal kinase (JNK) plays a part in endothelin-1-induced vascular endothelial growth factor synthesis in osteoblasts.
Journal of cellular biochemistry 2002;87(4):417-23.
2002: Kozawa Osamu; Niwa Masayuki; Hatakeyama Daijiro; Tokuda Haruhiko; Oiso Yutaka; Matsuno Hiroyuki; Kato Kanefusa; Uematsu Toshihiko
Specific induction of heat shock protein 27 by glucocorticoid in osteoblasts.
Journal of cellular biochemistry 2002;86(2):357-64.
2002: Hatakeyama Daijiro; Kozawa Osamu; Otsuka Takanobu; Shibata Toshiyuki; Uematsu Toshihiko
Zinc suppresses IL-6 synthesis by prostaglandin F2alpha in osteoblasts: inhibition of phospholipase C and phospholipase D.
Journal of cellular biochemistry 2002;85(3):621-8.
2002: Kozawa Osamu; Hatakeyama Daijiro; Uematsu Toshihiko
Divergent regulation by p44/p42 MAP kinase and p38 MAP kinase of bone morphogenetic protein-4-stimulated osteocalcin synthesis in osteoblasts.
Journal of cellular biochemistry 2002;84(3):583-9.
2001: Hotta K; Niwa M; Hara A; Ohno T; Wang X; Matsuno H; Kozawa O; Ito H; Kato K; Otsuka T; Matsui N; Uematsu T
The loss of susceptibility to apoptosis in exudated tissue neutrophils is associated with their nuclear factor-kappa B activation.
European journal of pharmacology 2001;433(1):17-27.
2001: Hatakeyama D; Kozawa O; Niwa M; Matsuno H; Kato K; Tatematsu N; Shibata T; Uematsu T
Inhibition by adenylyl cyclase-cAMP system of ET-1-induced HSP27 in osteoblasts.
American journal of physiology. Endocrinology and metabolism 2001;281(6):E1260-6.
2001: Niwa M; Hotta K; Kanamori Y; Matsuno H; Kozawa O; Hirota M; Uematsu T
Differential uptake of grepafloxacin by human circulating blood neutrophils and those exudated into tissues.
European journal of pharmacology 2001;428(1):121-6.
2001: Kozawa O; Hatakeyama D; Yoshida M; Kamiya Y; Kondo C; Matsuno H; Uematsu T
Activation of p44/p42 mitogen-activated protein kinase limits triiodothyronine-stimulated alkaline phosphatase activity in osteoblasts.
Biochemical and biophysical research communications 2001;286(5):1140-3.
2001: Tokuda H; Kozawa O; Miwa M; Uematsu T
p38 mitogen-activated protein (MAP) kinase but not p44/p42 MAP kinase is involved in prostaglandin E1-induced vascular endothelial growth factor synthesis in osteoblasts.
The Journal of endocrinology 2001;170(3):629-38.
2001: Nishida M; Matsuno H; Niwa M; Kozawa O; Ito Y; Miyata H; Uematsu T
Photochemically induced equilibrium dysfunction in the hamster model with evaluation by means of a new globe rotatory test system.
The Annals of otology, rhinology, and laryngology 2001;110(8):758-64.
2001: Kozawa O; Otsuka T; Hatakeyama D; Niwa M; Matsuno H; Ito H; Kato K; Matsui N; Uematsu T
Mechanism of prostaglandin D(2)-stimulated heat shock protein 27 induction in osteoblasts.
Cellular signalling 2001;13(8):535-41.
2001: Matsuno H; Kozawa O; Niwa M; Abe A; Takiguchi Y; Uematsu T
Characterization of simple and reproducible vascular stenosis model in hypercholesterolemic hamsters.
Lipids 2001;36(5):453-60.
2001: Kozawa O; Niwa M; Matsuno H; Ishisaki A; Kato K; Uematsu T
Stimulatory effect of basic fibroblast growth factor on induction of heat shock protein 27 in osteoblasts: role of protein kinase C.
Archives of biochemistry and biophysics 2001;388(2):237-42.
2001: Kozawa O; Uematsu T; Matsuno H; Niwa M; Kohno K; Kawato A; Takahashi K; Nagashima S; Kanamaru M
Pharmacokinetics of a new parenteral oligosaccharide antibiotic, SCH27899 (Ziracin), in healthy subjects.
Antimicrobial agents and chemotherapy 2001;45(3):917-21.
2001: Kozawa O; Matsuno H; Niwa M; Hatakeyama D; Kato K; Uematsu T
AlphaB-crystallin, a low-molecular-weight heat shock protein, acts as a regulator of platelet function.
Cell stress & chaperones 2001;6(1):21-8.
2001: Tanabe K; Kozawa O; Niwa M; Yamomoto T; Matsuno H; Ito H; Kato K; Dohi S; Uematsu T
Contrasting effects of midazolam on induction of heat shock protein 27 by vasopressin and heat in aortic smooth muscle cells.
Journal of cellular biochemistry 2001;84(1):39-46.
2001: Yamamoto T; Kozawa O; Tanabe K; Akamatsu S; Matsuno H; Dohi S; Uematsu T
Involvement of p38 MAP kinase in TGF-beta-stimulated VEGF synthesis in aortic smooth muscle cells.
Journal of cellular biochemistry 2001;82(4):591-8.
2001: Kozawa O; Matsuno H; Uematsu T
Involvement of p70 S6 kinase in bone morphogenetic protein signaling: vascular endothelial growth factor synthesis by bone morphogenetic protein-4 in osteoblasts.
Journal of cellular biochemistry 2001;81(3):430-6.
2000: Tokuda H; Kozawa O; Uematsu T
Basic fibroblast growth factor stimulates vascular endothelial growth factor release in osteoblasts: divergent regulation by p42/p44 mitogen-activated protein kinase and p38 mitogen-activated protein kinase.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2000;15(12):2371-9.
2000: Nishida M; Matsuno H; Kozawa O; Ueshima S; Matsuo O; Collen D; Uematsu T
tPA, but not uPA, significantly affects antithrombotic therapy by a glycoprotein IIb/IIIa antagonist, but not by a factor Xa inhibitor.
Journal of cardiovascular pharmacology 2000;36(6):770-5.
2000: Niwa M; Hara A; Kanamori Y; Hatakeyama D; Saio M; Takami T; Matsuno H; Kozawa O; Uematsu T
Nuclear factor-kappaB activates dual inhibition sites in the regulation of tumor necrosis factor-alpha-induced neutrophil apoptosis.
European journal of pharmacology 2000;407(3):211-9.
2000: Nagashima S; Kozawa O; Otsuka T; Kohno K; Minamoto M; Yokokawa M; Kanamaru M; Uematsu T
Pharmacokinetics of a parenteral carbapenem, biapenem, in patients with end-stage renal disease and influence of haemodialysis.
The Journal of antimicrobial chemotherapy 2000;46(5):839-42.
2000: Matsuno H; Kozawa O; Ueshima S; Matsuo O; Collen D; Uematsu T
The interaction between components of the fibrinolytic system and GPIb/V/IX of platelets thrombus formation in mice.
British journal of pharmacology 2000;131(4):858-64.
2000: Kozawa O; Yamamoto T; Tanabe K; Akamatsu S; Dohi S; Uematsu T
Enhancement by sphingosine 1-phosphate in vasopressin-induced phosphoinositide hydrolysis in aortic smooth-muscle cells: involvement of p38 MAP kinase.
Journal of cellular biochemistry 2000;80(1):46-52.
2000: Niwa M; Kanamori Y; Kohno K; Matsuno H; Kozawa O; Kanamura M; Uematsu T
Usefulness of grading of neutrophil aggregate size by laser-light scattering technique for characterizing stimulatory and inhibitory effects of agents on aggregation.
Life sciences 2000;67(13):1525-34.
2000: Uematsu T; Kozawa O; Matsuno H; Niwa M; Yoshikoshi H; Oh-uchi M; Kohno K; Nagashima S; Kanamaru M
Pharmacokinetics and tolerability of intravenous infusion of adenosine (SUNY4001) in healthy volunteers.
British journal of clinical pharmacology 2000;50(2):177-81.
2000: Kozawa O; Kawamura H; Matsuno H; Uematsu T
p38 MAP kinase is involved in the signalling of sphingosine in osteoblasts: sphingosine inhibits prostaglandin F(2alpha)-induced phosphoinositide hydrolysis.
Cellular signalling 2000;12(7):447-50.
2000: Kozawa O; Kawamura H; Uematsu T
Sphingosine 1-phosphate amplifies phosphoinositide hydrolysis stimulated by prostaglandin f2 alpha in osteoblasts: involvement of p38MAP kinase.
Prostaglandins, leukotrienes, and essential fatty acids 2000;62(6):355-9.
2000: Kozawa O; Kawamura H; Hatakeyama D; Matsuno H; Uematsu T
Endothelin-1 induces vascular endothelial growth factor synthesis in osteoblasts: involvement of p38 mitogen-activated protein kinase.
Cellular signalling 2000;12(6):375-80.
2000: Kozawa O; Tanabe K; Matsuno H; Niwa M; Yamamoto T; Akamatsu S; Kato K; Dohi S; Uematsu T
Pentobarbital, but not propofol, suppresses vasopressin-stimulated heat shock protein 27 induction in aortic smooth muscle cells.
Anesthesiology 2000;92(6):1807-13.
2000: Matsuno H; Kozawa O; Ueshima S; Matsuo O; Collen D; Uematsu T
Lack of tPA significantly affects antithrombotic therapy by a GPIIb/IIIa antagonist, but not by a thrombin inhibitor in mice.
Thrombosis and haemostasis 2000;83(4):605-9.
2000: Sassa T; Matsuno H; Niwa M; Kozawa O; Takeda N; Niwa T; Kumada T; Uematsu T
Measurement of furancarboxylic acid, a candidate for uremic toxin, in human serum, hair, and sweat, and analysis of pharmacological actions in vitro.
Archives of toxicology 2000;73(12):649-54.
2000: Ito T; Kozawa O; Tanabe K; Niwa M; Matsuno H; Sakai N; Ito H; Kato K; Uematsu T
p38 MAP kinase is required for vasopressin-stimulated HSP27 induction in aortic smooth muscle cells.
Hypertension 2000;35(2):673-8.
2000: Niwa M; Kozawa O; Matsuno H; Kanamori Y; Hara A; Uematsu T
Tumor necrosis factor-alpha-mediated signal transduction in human neutrophils: involvement of sphingomyelin metabolites in the priming effect of TNF-alpha on the fMLP-stimulated superoxide production.
Life sciences 2000;66(3):245-56.
2000: Niwa M; Kozawa O; Matsuno H; Kato K; Uematsu T
Small molecular weight heat shock-related protein, HSP20, exhibits an anti-platelet activity by inhibiting receptor-mediated calcium influx.
Life sciences 2000;66(1):PL7-12.
1999: Kawamura H; Otsuka T; Matsuno H; Niwa M; Matsui N; Kato K; Uematsu T; Kozawa O
Endothelin-1 stimulates heat shock protein 27 induction in osteoblasts: involvement of p38 MAP kinase.
The American journal of physiology 1999;277(6 Pt 1):E1046-54.
1999: Kozawa O; Tokuda H; Miwa M; Ito H; Matsuno H; Niwa M; Kato K; Uematsu T
Involvement of p42/p44 mitogen-activated protein kinase in prostaglandin f(2alpha)-stimulated induction of heat shock protein 27 in osteoblasts.
Journal of cellular biochemistry 1999;75(4):610-9.
1999: Kozawa O; Niwa M; Matsuno H; Tokuda H; Miwa M; Ito H; Kato K; Uematsu T
Sphingosine 1-phosphate induces heat shock protein 27 via p38 mitogen-activated protein kinase activation in osteoblasts.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1999;14(10):1761-7.
1999: Tokuda H; Kozawa O; Harada A; Uematsu T
Prostaglandin D2 induces interleukin-6 synthesis via Ca2+ mobilization in osteoblasts: regulation by protein kinase C.
Prostaglandins, leukotrienes, and essential fatty acids 1999;61(3):189-94.
1999: Kozawa O; Tokuda H; Matsuno H; Uematsu T
Involvement of p38 mitogen-activated protein kinase in basic fibroblast growth factor-induced interleukin-6 synthesis in osteoblasts.
Journal of cellular biochemistry 1999;74(3):479-85.
1999: Kozawa O; Tanabe K; Ito H; Matsuno H; Niwa M; Kato K; Uematsu T
Sphingosine 1-phosphate regulates heat shock protein 27 induction by a p38 MAP kinase-dependent mechanism in aortic smooth muscle cells.
Experimental cell research 1999;250(2):376-80.
1999: Matsuno H; Kozawa O; Nagashima S; Kanamaru M; Uematsu T
Comparative antiplatelet effects of aspirin, vapiprost and GR144053, a GPIIb/IIIa antagonist, with a special reference to the role of platelet microaggregates.
British journal of pharmacology 1999;127(5):1129-34.
1999: Ito T; Matsuno H; Kozawa O; Niwa M; Sakai N; Uematsu T
Comparison of the antithrombotic effects and bleeding risk of fractionated aurin tricarboxylic acid and the GPIIb/IIIa antagonist GR144053 in a hamster model of stenosis.
Thrombosis research 1999;95(1):49-61.
1999: Niwa M; Hara A; Kanamori Y; Matsuno H; Kozawa O; Yoshimi N; Mori H; Uematsu T
Inhibition of tumor necrosis factor-alpha induced neutrophil apoptosis by cyclic AMP: involvement of caspase cascade.
European journal of pharmacology 1999;371(1):59-67.
1999: Matsuno H; Kozawa O; Niwa M; Ueshima S; Matsuo O; Collen D; Uematsu T
Differential role of components of the fibrinolytic system in the formation and removal of thrombus induced by endothelial injury.
Thrombosis and haemostasis 1999;81(4):601-4.
1999: Kawamura H; Otsuka T; Tokuda H; Matsuno H; Niwa M; Matsui N; Uematsu T; Kozawa O
Involvement of p42/p44 MAP kinase in endothelin-1-induced interleukin-6 synthesis in osteoblast-like cells.
Bone 1999;24(4):315-20.
1999: Tokuda H; Kozawa O; Harada A; Uematsu T
Extracellular sphingomyelinase induces interleukin-6 synthesis in osteoblasts.
Journal of cellular biochemistry 1999;72(2):262-8.
1999: Kaida T; Kozawa O; Ito T; Tanabe K; Ito H; Matsuno H; Niwa M; Miyata H; Uematsu T; Kato K
Vasopressin stimulates the induction of heat shock protein 27 and alphaB-crystallin via protein kinase C activation in vascular smooth muscle cells.
Experimental cell research 1999;246(2):327-37.
1999: Tanabe K; Kozawa O; Matsuno H; Niwa M; Dohi S; Uematsu T
Effect of propofol on arachidonate cascade by vasopressin in aortic smooth muscle cells: inhibition of PGI2 synthesis.
Anesthesiology 1999;90(1):215-24.
1998: Kozawa O; Tokuda H; Matsuno H; Uematsu T
Sphingosine modulates interleukin-6 synthesis in osteoblasts.
Journal of cellular biochemistry 1998;70(3):338-45.
1998: Matsuno H; Kozawa O; Niwa M; Ito T; Tanabe K; Nishida M; Hayashi H; Uematsu T
Effect of GR144053, a fibrinogen-receptor antagonist, on thrombus formation and vascular patency after thrombolysis by tPA in the injured carotid artery of the hamster.
Journal of cardiovascular pharmacology 1998;32(2):191-7.
1998: Matsuno H; Kozawa O; Niwa M; Usui A; Ito H; Uematsu T; Kato K
A heat shock-related protein, p20, plays an inhibitory role in platelet activation.
FEBS letters 1998;429(3):327-9.
1998: Kozawa O; Uematsu T; Matsuno H; Niwa M; Takiguchi Y; Matsumoto S; Minamoto M; Niida Y; Yokokawa M; Nagashima S; Kanamaru M
Pharmacokinetics and safety of a new parenteral carbapenem antibiotic, biapenem (L-627), in elderly subjects.
Antimicrobial agents and chemotherapy 1998;42(6):1433-6.
1998: Tokuda H; Kozawa O; Harada A; Uematsu T
Tiludronate inhibits interleukin-6 synthesis in osteoblasts: inhibition of phospholipase D activation in MC3T3-E1 cells.
Journal of cellular biochemistry 1998;69(3):252-9.
1998: Akter U; Niwa M; Nose T; Kaida T; Matsuno H; Kozawa O; Uematsu T
Effects of several agents on UVB- and UVA plus systemic fluoroquinolone-induced erythema of guinea pig skin evaluated by reflectance colorimetry.
Free radical biology & medicine 1998;24(7-8):1113-9.
1998: Matsuno H; Kozawa O; Niwa M; Tanabe K; Ichimaru K; Takiguchi Y; Yokota M; Hayashi H; Uematsu T
Multiple inhibition of platelet activation by aurintricarboxylic acid prevents vascular stenosis after endothelial injury in hamster carotid artery.
Thrombosis and haemostasis 1998;79(4):865-71.
1998: Kozawa O; Suzuki A; Tokuda H; Kaida T; Uematsu T
Interleukin-6 synthesis induced by prostaglandin E2: cross-talk regulation by protein kinase C.
Bone 1998;22(4):355-60.
1998: Kozawa O; Tokuda H; Kaida T; Matsuno H; Uematsu T
Retinoic acid suppresses interleukin-6 synthesis induced by prostaglandins in osteoblasts.
Prostaglandins, leukotrienes, and essential fatty acids 1998;58(3):215-9.
1998: Tokuda H; Kozawa O; Harada A; Isobe K I; Uematsu T
Triiodothyronine modulates interleukin-6 synthesis in osteoblasts: inhibitions in protein kinase A and C pathways.
Endocrinology 1998;139(3):1300-5.
1998: Kozawa O; Tokuda H; Kaida T; Matsuno H; Uematsu T
Effect of vitamin D3 on interleukin-6 synthesis induced by prostaglandins in osteoblasts.
Prostaglandins, leukotrienes, and essential fatty acids 1998;58(2):119-23.
1998: Matsuno M; Kozawa O; Suzuki A; Tokuda H; Kaida T; Matsuno H; Niwa M; Uematsu T
Involvement of protein kinase C activation in endothelin-1-induced secretion of interleukin-6 in osteoblast-like cells.
Cellular signalling 1998;10(2):107-11.
1998: Tanabe K; Kozawa O; Kaida T; Matsuno H; Niwa M; Ohta S; Dohi S; Uematsu T
Inhibitory effects of propofol on intracellular signaling by endothelin-1 in aortic smooth muscle cells.
Anesthesiology 1998;88(2):452-60.
1997: Matsuno H; Kozawa O; Niwa M; Kaida T; Hayashi H; Uematsu T
GR144053, a fibrinogen receptor antagonist, enhances the suppression of neointima formation by losartan, an angiotensin II receptor antagonist, in the injured carotid artery of hamster.
British journal of pharmacology 1997;122(6):1099-104.
1997: Kozawa O; Tokuda H; Matsuno H; Uematsu T
Activation of mitogen-activated protein kinase is involved in sphingosine 1-phosphate-stimulated interleukin-6 synthesis in osteoblasts.
FEBS letters 1997;418(1-2):149-51.
1997: Kozawa O; Suzuki A; Tokuda H; Kaida T; Uematsu T
Protein kinase C activation by interleukin (IL)-1 limits IL-1-induced IL-6 synthesis in osteoblast-like cells: involvement of phosphatidylcholine-specific phospholipase C.
Journal of cellular biochemistry 1997;67(1):103-11.
1997: Kozawa O; Suzuki A; Kaida T; Tokuda H; Uematsu T
Tumor necrosis factor-alpha autoregulates interleukin-6 synthesis via activation of protein kinase C. Function of sphingosine 1-phosphate and phosphatidylcholine-specific phospholipase C.
The Journal of biological chemistry 1997;272(40):25099-104.
1997: Kozawa O; Suzuki A; Uematsu T
Basic fibroblast growth factor induces interleukin-6 synthesis in osteoblasts: autoregulation by protein kinase C.
Cellular signalling 1997;9(6):463-8.
1997: Kozawa O; Tokuda H; Kaida T; Matsuno H; Uematsu T
Thrombin regulates interleukin-6 synthesis through phosphatidylcholine hydrolysis by phospholipase D in osteoblasts.
Archives of biochemistry and biophysics 1997;345(1):10-5.
1997: Matsuno H; Kozawa O; Niwa M; Uematsu T
Inhibition of von Willebrand factor binding to platelet GP Ib by a fractionated aurintricarboxylic acid prevents restenosis after vascular injury in hamster carotid artery.
Circulation 1997;96(4):1299-304.
1997: Kaida T; Matsuno H; Niwa M; Kozawa O; Miyata H; Uematsu T
Antiplatelet effect of FK633, a platelet glycoprotein IIb/IIIa antagonist, on thrombus formation and vascular patency after thrombolysis in the injured hamster carotid artery.
Thrombosis and haemostasis 1997;77(3):562-7.
1997: Kozawa O; Suzuki A; Shinoda J; Ozaki N; Oiso Y; Uematsu T
Involvement of phospholipase D activation in endothelin-1-induced release of arachidonic acid in osteoblast-like cells.
Journal of cellular biochemistry 1997;64(3):376-81.
1997: Kozawa O; Suzuki A; Tokuda H; Uematsu T
Prostaglandin F2alpha stimulates interleukin-6 synthesis via activation of PKC in osteoblast-like cells.
The American journal of physiology 1997;272(2 Pt 1):E208-11.
1997: Kanamori Y; Niwa M; Kohno K; Al-Essa L Y; Matsuno H; Kozawa O; Uematsu T
Migration of neutrophils from blood to tissue: alteration of modulatory effects of prostanoid on superoxide generation in rabbits and humans.
Life sciences 1997;60(16):1407-17.

Sign-in to see more