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Ivan Kozekov

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Chemicals & Drugs

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Nucleic Acid Conformation

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Linlin Zhao; Plamen P Christov; Martin Egli; Ivan D Kozekov; Pradeep S Pallan; Matthew G Pence; Carmelo J Rizzo; F Peter Guengerich
Replication of N2,3-ethenoguanine by DNA polymerases.
Constance M Harris; Ivan D Kozekov; Carmelo J Rizzo; Donald F Stec; Plamen P Christov; Thomas M Harris
Deoxyguanosine forms a bis-adduct with E,E-muconaldehyde, an oxidative metabolite of benzene: implications for the carcinogenicity of benzene.
Ganesh Shanmugam; F Peter Guengerich; Ivan D Kozekov; Carmelo J Rizzo; Michael P Stone
1,N2-Etheno-2'-deoxyguanosine adopts the syn conformation about the glycosyl bond when mismatched with deoxyadenosine.

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All Publications

2012: Linlin Zhao; Plamen P Christov; Martin Egli; Ivan D Kozekov; Pradeep S Pallan; Matthew G Pence; Carmelo J Rizzo; F Peter Guengerich
Replication of N2,3-ethenoguanine by DNA polymerases.
Angewandte Chemie (International ed. in English) 2012;51(22):5466-9.
2011: Constance M Harris; Ivan D Kozekov; Carmelo J Rizzo; Donald F Stec; Plamen P Christov; Thomas M Harris
Deoxyguanosine forms a bis-adduct with E,E-muconaldehyde, an oxidative metabolite of benzene: implications for the carcinogenicity of benzene.
Chemical research in toxicology 2011;24(11):1944-56.
2011: Ganesh Shanmugam; F Peter Guengerich; Ivan D Kozekov; Carmelo J Rizzo; Michael P Stone
1,N2-Etheno-2'-deoxyguanosine adopts the syn conformation about the glycosyl bond when mismatched with deoxyadenosine.
Chemical research in toxicology 2011;24(7):1071-9.
2010: Ivan D Kozekov; Robert J Turesky; Guillermo R Alas; Constance M Harris; Thomas M Harris; Carmelo J Rizzo
Formation of deoxyguanosine cross-links from calf thymus DNA treated with acrolein and 4-hydroxy-2-nonenal.
Chemical research in toxicology 2010;23(11):1701-13.
2010: Plamen P Christov; Katya V Petrova; Ganesh Shanmugam; Ivan D Kozekov; Albena Kozekova; F Peter Guengerich; Michael P Stone; Carmelo J Rizzo
Comparison of the in vitro replication of the 7-(2-oxoheptyl)-1,N2-etheno-2'-deoxyguanosine and 1,N2-etheno-2'-deoxyguanosine lesions by Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4).
Chemical research in toxicology 2010;23(8):1330-41.
2010: Hai Huang; Ivan D Kozekov; Albena Kozekova; Carmelo J Rizzo; Amanda K McCullough; R Stephen Lloyd; Michael P Stone
Minor groove orientation of the KWKK peptide tethered via the N-terminal amine to the acrolein-derived 1,N2-gamma-hydroxypropanodeoxyguanosine lesion with a trimethylene linkage.
Biochemistry 2010;49(29):6155-64.
2010: Hai Huang; Ivan D Kozekov; Albena Kozekova; Hao Wang; R Stephen Lloyd; Carmelo J Rizzo; Michael P Stone
DNA cross-link induced by trans-4-hydroxynonenal.
Environmental and molecular mutagenesis 2010;51(6):625-34.
2010: Ganesh Shanmugam; Ivan D Kozekov; F Peter Guengerich; Carmelo J Rizzo; Michael P Stone
Structure of the 1,N(2)-etheno-2'-deoxyguanosine lesion in the 3'-G(epsilon dG)T-5' sequence opposite a one-base deletion.
Biochemistry 2010;49(12):2615-26.
2010: Kinrin Yamanaka; Irina G Minko; Kei-ichi Takata; Alexander Kolbanovskiy; Ivan D Kozekov; Richard D Wood; Carmelo J Rizzo; R Stephen Lloyd
Novel enzymatic function of DNA polymerase nu in translesion DNA synthesis past major groove DNA-peptide and DNA-DNA cross-links.
Chemical research in toxicology 2010;23(3):689-95.
2009: Huidong Zhang; Urban Bren; Ivan D Kozekov; Carmelo J Rizzo; Donald F Stec; F Peter Guengerich
Steric and electrostatic effects at the C2 atom substituent influence replication and miscoding of the DNA deamination product deoxyxanthosine and analogs by DNA polymerases.
Journal of molecular biology 2009;392(2):251-69.
2009: Merav Ben-Yehoyada; Lily C Wang; Ivan D Kozekov; Carmelo J Rizzo; Max E Gottesman; Jean Gautier
Checkpoint signaling from a single DNA interstrand crosslink.
Molecular cell 2009;35(5):704-15.
2009: Huidong Zhang; Robert L Eoff; Ivan D Kozekov; Carmelo J Rizzo; Martin Egli; F Peter Guengerich
Structure-function relationships in miscoding by Sulfolobus solfataricus DNA polymerase Dpo4: guanine N2,N2-dimethyl substitution produces inactive and miscoding polymerase complexes.
The Journal of biological chemistry 2009;284(26):17687-99.
2009: Hai Huang; Hye-Young Kim; Ivan D Kozekov; Young-Jin Cho; Hao Wang; Albena Kozekova; Thomas Harris; Carmelo J Rizzo; Michael P Stone
Stereospecific formation of the (R)-gamma-hydroxytrimethylene interstrand N2-dG:N2-dG cross-link arising from the gamma-OH-1,N2-propano-2'-deoxyguanosine adduct in the 5'-CpG-3' DNA sequence.
Journal of the American Chemical Society 2009;131(24):8416-24.
2009: Irina G Minko; Ivan D Kozekov; Thomas M Harris; Carmelo J Rizzo; R Stephen Lloyd; Michael P Stone
Chemistry and biology of DNA containing 1,N(2)-deoxyguanosine adducts of the alpha,beta-unsaturated aldehydes acrolein, crotonaldehyde, and 4-hydroxynonenal.
Chemical research in toxicology 2009;22(5):759-78.
2009: Huidong Zhang; Robert L Eoff; Ivan D Kozekov; Carmelo J Rizzo; Martin Egli; F Peter Guengerich
Versatility of Y-family Sulfolobus solfataricus DNA polymerase Dpo4 in translesion synthesis past bulky N2-alkylguanine adducts.
The Journal of biological chemistry 2009;284(6):3563-76.
2009: Charles G Knutson; Emily H Rubinson; Dapo Akingbade; Carolyn S Anderson; Donald F Stec; Katya V Petrova; Ivan D Kozekov; F Peter Guengerich; Carmelo J Rizzo; Lawrence J Marnett
Oxidation and glycolytic cleavage of etheno and propano DNA base adducts.
Biochemistry 2009;48(4):800-9.
2009: Erin E Bessette; Angela K Goodenough; Sophie Langouët; Isil Yasa; Ivan D Kozekov; Simon Spivack; Robert J Turesky
Screening for DNA adducts by data-dependent constant neutral loss-triple stage mass spectrometry with a linear quadrupole ion trap mass spectrometer.
Analytical chemistry 2009;81(2):809-19.
2008: Irina G Minko; Kinrin Yamanaka; Ivan D Kozekov; Albena Kozekova; Chiara Indiani; Michael E O'Donnell; QINGFEI JIANG; Myron F Goodman; Carmelo J Rizzo; R Stephen Lloyd
Replication bypass of the acrolein-mediated deoxyguanine DNA-peptide cross-links by DNA polymerases of the DinB family.
Chemical research in toxicology 2008;21(10):1983-90.
2008: Ganesh Shanmugam; Ivan D Kozekov; F Peter Guengerich; Carmelo J Rizzo; Michael P Stone
Structure of the 1,N2-ethenodeoxyguanosine adduct opposite cytosine in duplex DNA: Hoogsteen base pairing at pH 5.2.
Chemical research in toxicology 2008;21(9):1795-805.
2008: Plamen P Christov; Ivan D Kozekov; Carmelo J Rizzo; Thomas Harris
The formamidopyrimidine derivative of 7-(2-oxoethyl)-2'-deoxyguanosine.
Chemical research in toxicology 2008;21(9):1777-86.
2008: Michael P Stone; Young-Jin Cho; Hai Huang; Hye-Young Kim; Ivan D Kozekov; Albena Kozekova; Hao Wang; Irina G Minko; R Stephen Lloyd; Thomas Harris; Carmelo J Rizzo
Interstrand DNA cross-links induced by alpha,beta-unsaturated aldehydes derived from lipid peroxidation and environmental sources.
Accounts of chemical research 2008;41(7):793-804.
2008: Irina G Minko; Michael Harbut; Ivan D Kozekov; Albena Kozekova; Petra Jakobs; Susan B Olson; Robb Moses; Thomas Harris; Carmelo J Rizzo; R Stephen Lloyd
Role for DNA polymerase kappa in the processing of N2-N2-guanine interstrand cross-links.
The Journal of biological chemistry 2008;283(25):17075-82.
2008: Irina G Minko; Ivan D Kozekov; Albena Kozekova; Thomas Harris; Carmelo J Rizzo; R Stephen Lloyd
Mutagenic potential of DNA-peptide crosslinks mediated by acrolein-derived DNA adducts.
Mutation research 2008;637(1-2):161-72.
2007: Ganesh Shanmugam; Angela K Goodenough; Ivan D Kozekov; F Peter Guengerich; Carmelo J Rizzo; Michael P Stone
Structure of the 1,N2-etheno-2'-deoxyguanosine adduct in duplex DNA at pH 8.6.
Chemical research in toxicology 2007;20(11):1601-11.
2007: Katya V Petrova; Ravikumar S Jalluri; Ivan D Kozekov; Carmelo J Rizzo
Mechanism of 1,N2-etheno-2'-deoxyguanosine formation from epoxyaldehydes.
Chemical research in toxicology 2007;20(11):1685-92.
2007: Young-Jin Cho; Ivan D Kozekov; Thomas Harris; Carmelo J Rizzo; Michael P Stone
Stereochemistry modulates the stability of reduced interstrand cross-links arising from R- and S-alpha-CH3-gamma-OH-1,N2-propano-2'-deoxyguanosine in the 5'-CpG-3' DNA sequence.
Biochemistry 2007;46(10):2608-21.
2006: Hao Wang; Ivan D Kozekov; Albena Kozekova; Pamela J Tamura; Lawrence J Marnett; Thomas Harris; Carmelo J Rizzo
Site-specific synthesis of oligonucleotides containing malondialdehyde adducts of deoxyguanosine and deoxyadenosine via a postsynthetic modification strategy.
Chemical research in toxicology 2006;19(11):1467-74.
2006: Young-Jin Cho; Hao Wang; Ivan D Kozekov; Albena Kozekova; Andrew J Kurtz; Jaison Jacob; Markus Voehler; Jarrod Smith; Thomas Harris; Carmelo J Rizzo; R Stephen Lloyd; Michael P Stone
Orientation of the crotonaldehyde-derived N2-[3-Oxo-1(S)-methyl-propyl]-dG DNA adduct hinders interstrand cross-link formation in the 5'-CpG-3' sequence.
Chemical research in toxicology 2006;19(8):1019-29.
2006: Priscilla H Fernandes; Linda C Hackfeld; Ivan D Kozekov; Richard P Hodge; R Stephen Lloyd
Synthesis and mutagenesis of the butadiene-derived N3 2'-deoxyuridine adducts.
Chemical research in toxicology 2006;19(7):968-76.
2006: Jeong-Yun Choi; Hong Zang; Karen C Angel; Ivan D Kozekov; Angela K Goodenough; Carmelo J Rizzo; F Peter Guengerich
Translesion synthesis across 1,N2-ethenoguanine by human DNA polymerases.
Chemical research in toxicology 2006;19(6):879-86.
2006: Young-Jin Cho; Hao Wang; Ivan D Kozekov; Andrew J Kurtz; Jaison Jacob; Markus Voehler; Jarrod Smith; Thomas Harris; R Stephen Lloyd; Carmelo J Rizzo; Michael P Stone
Stereospecific formation of interstrand carbinolamine DNA cross-links by crotonaldehyde- and acetaldehyde-derived alpha-CH3-gamma-OH-1,N2-propano-2'-deoxyguanosine adducts in the 5'-CpG-3' sequence.
Chemical research in toxicology 2006;19(2):195-208.
2006: Meglena I Kandinska; Ivan D Kozekov; Mariana D Palamareva
Synthesis of new trans-2-benzyl-3-(furan-2-yl)-4-substituted-1,2,3,4-tetrahydroisoquinolinones.
Molecules (Basel, Switzerland) 2006;11(6):403-14.
2005: Young-Jin Cho; Hye-Young Kim; Hai Huang; Alvira Slutsky; Irina G Minko; Hao Wang; Lubomir V Nechev; Ivan D Kozekov; Albena Kozekova; Pamela J Tamura; Jaison Jacob; Markus Voehler; Thomas Harris; R Stephen Lloyd; Carmelo J Rizzo; Michael P Stone
Spectroscopic characterization of interstrand carbinolamine cross-links formed in the 5'-CpG-3' sequence by the acrolein-derived gamma-OH-1,N2-propano-2'-deoxyguanosine DNA adduct.
Journal of the American Chemical Society 2005;127(50):17686-96.
2005: Angela K Goodenough; Ivan D Kozekov; Hong Zang; Jeong-Yun Choi; F Peter Guengerich; Thomas Harris; Carmelo J Rizzo
Site specific synthesis and polymerase bypass of oligonucleotides containing a 6-hydroxy-3,5,6,7-tetrahydro-9H-imidazo[1,2-a]purin-9-one base, an intermediate in the formation of 1,N2-etheno-2'-deoxyguanosine.
Chemical research in toxicology 2005;18(11):1701-14.
2005: Ana M Sanchez; Ivan D Kozekov; Thomas Harris; R Stephen Lloyd
Formation of inter- and intrastrand imine type DNA-DNA cross-links through secondary reactions of aldehydic adducts.
Chemical research in toxicology 2005;18(11):1683-90.
2005: Hong Zang; Angela K Goodenough; Jeong-Yun Choi; adriana irimia; Lioudmila V Loukachevitch; Ivan D Kozekov; Karen C Angel; Carmelo J Rizzo; Martin Egli; F Peter Guengerich
DNA adduct bypass polymerization by Sulfolobus solfataricus DNA polymerase Dpo4: analysis and crystal structures of multiple base pair substitution and frameshift products with the adduct 1,N2-ethenoguanine.
The Journal of biological chemistry 2005;280(33):29750-64.
2004: Angela K Brock; Ivan D Kozekov; Carmelo J Rizzo; Thomas Harris
Coupling products of nucleosides with the glyoxal adduct of deoxyguanosine.
Chemical research in toxicology 2004;17(8):1047-56.
2003: Hao Wang; Ivan D Kozekov; Thomas Harris; Carmelo J Rizzo
Site-specific synthesis and reactivity of oligonucleotides containing stereochemically defined 1,N2-deoxyguanosine adducts of the lipid peroxidation product trans-4-hydroxynonenal.
Journal of the American Chemical Society 2003;125(19):5687-700.
2003: Ivan D Kozekov; Lubomir V Nechev; M Scott Moseley; Constance M Harris; Carmelo J Rizzo; Michael P Stone; Thomas Harris
DNA interchain cross-links formed by acrolein and crotonaldehyde.
Journal of the American Chemical Society 2003;125(1):50-61.
2002: Lubomir V Nechev; Ivan D Kozekov; Angela K Brock; Carmelo J Rizzo; Thomas Harris
DNA adducts of acrolein: site-specific synthesis of an oligodeoxynucleotide containing 6-hydroxy-5,6,7,8-tetrahydropyrimido[1,2-a]purin-10(3H)-one, an acrolein adduct of guanine.
Chemical research in toxicology 2002;15(5):607-13.
2001: Lubomir V Nechev; Ivan D Kozekov; Constance M Harris; Thomas Harris
Stereospecific synthesis of oligonucleotides containing crotonaldehyde adducts of deoxyguanosine.
Chemical research in toxicology 2001;14(11):1506-12.
2001: Ivan D Kozekov; Lubomir V Nechev; A Sanchez; Constance M Harris; R Stephen Lloyd; Thomas Harris
Interchain cross-linking of DNA mediated by the principal adduct of acrolein.
Chemical research in toxicology 2001;14(11):1482-5.