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Sara Kozma

Research Profile

Chemicals & Drugs

Physiology

Genes & Molecular Sequences

Amino Acid Sequences

Anatomy

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Publications

TOP 3
Hala Elnakat Thomas; Snorri S Thorgeirsson; Jesper B Andersen; Bruce J Aronow; Larissa Carnevalli; Elizabeth A Conner; Akio Iwanami; S Michel Maira; Liu Manway; Tomoo Matsutani; Carol A Mercer; Paul S Mischel; Jongsun Park; Kazuhiro Tanaka; George Thomas; Sara C Kozma
mTOR inhibitors synergize on regression, reversal of gene expression, and autophagy in hepatocellular carcinoma.
Molly M McFarland-Mancini; Holly M Funk; Andrew M Paluch; Mingfu Zhou; Premkumar Vummidi Giridhar; Carol A Mercer; Sara C Kozma; Angela F Drew
Differences in wound healing in mice with deficiency of IL-6 versus IL-6 receptor.
Larissa Carnevalli; Kouhei Masuda; Francesca Frigerio; Olivier Le Bacquer; Sung Hee Um; Valentina Gandin; Ivan Topisirovic; Nahum Sonenberg; George Thomas; Sara C Kozma
S6K1 plays a critical role in early adipocyte differentiation.

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All Publications

2012: Hala Elnakat Thomas; Snorri S Thorgeirsson; Jesper B Andersen; Bruce J Aronow; Larissa Carnevalli; Elizabeth A Conner; Akio Iwanami; S Michel Maira; Liu Manway; Tomoo Matsutani; Carol A Mercer; Paul S Mischel; Jongsun Park; Kazuhiro Tanaka; George Thomas; Sara C Kozma
mTOR inhibitors synergize on regression, reversal of gene expression, and autophagy in hepatocellular carcinoma.
Science translational medicine 2012;4(139):139ra84.
2010: Molly M McFarland-Mancini; Holly M Funk; Andrew M Paluch; Mingfu Zhou; Premkumar Vummidi Giridhar; Carol A Mercer; Sara C Kozma; Angela F Drew
Differences in wound healing in mice with deficiency of IL-6 versus IL-6 receptor.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(12):7219-28.
2010: Larissa Carnevalli; Kouhei Masuda; Francesca Frigerio; Olivier Le Bacquer; Sung Hee Um; Valentina Gandin; Ivan Topisirovic; Nahum Sonenberg; George Thomas; Sara C Kozma
S6K1 plays a critical role in early adipocyte differentiation.
Developmental cell 2010;18(5):763-74.
2010: Adem Kalender; Anand Selvaraj; So Young Kim; Pawan Gulati; Sophie Brûlé; Benoit Viollet; Bruce E Kemp; Nabeel Bardeesy; Patrick Dennis; John J Schlager; André Marette; Sara C Kozma; George Thomas
Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner.
Cell metabolism 2010;11(5):390-401.
2010: Jacques Montagne; Caroline Lecerf; Jean-Philippe Parvy; Janis M Bennion; Thomas Radimerski; Marie-Laure Ruhf; Frederic Zilbermann; nicole vouilloz; Hugo Stocker; Ernst Hafen; Sara C Kozma; George Thomas
The nuclear receptor DHR3 modulates dS6 kinase-dependent growth in Drosophila.
PLoS genetics 2010;6(5):e1000937.
2008: Pawan Gulati; Lawrence D Gaspers; Stephen G Dann; Manel Joaquin; Takahiro Nobukuni; Francois Natt; Sara C Kozma; Andrew P Thomas; George Thomas
Amino acids activate mTOR complex 1 via Ca2+/CaM signaling to hVps34.
Cell metabolism 2008;7(5):456-65.
2007: Takahiro Nobukuni; Sara C Kozma; George Thomas
hvps34, an ancient player, enters a growing game: mTOR Complex1/S6K1 signaling.
Current opinion in cell biology 2007;19(2):135-41.
2006: Daniela Cota; Karine Proulx; Kathi A Blake Smith; Sara C Kozma; George Thomas; Stephen C Woods; Randy J Seeley
Hypothalamic mTOR signaling regulates food intake.
Science (New York, N.Y.) 2006;312(5775):927-30.
2004: Yann-Gaël Gangloff; Matthias Mueller; Stephen G Dann; Petr Svoboda; Melanie Sticker; Jean-Francois Spetz; Sung Hee Um; Eric J Brown; Silvia Cereghini; George Thomas; Sara C Kozma
Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development.
Molecular and cellular biology 2004;24(21):9508-16.
2004: Sung Hee Um; Francesca Frigerio; Mitsuhiro Watanabe; Frédéric Picard; Manel Joaquin; Melanie Sticker; Stefano Fumagalli; Peter R Allegrini; Sara C Kozma; Johan Auwerx; George Thomas
Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity.
Nature 2004;431(7005):200-5.
2004: Mario Pende; Sung Hee Um; Virginie Mieulet; Melanie Sticker; Valerie L Goss; Jürgen Mestan; Matthias Mueller; Stefano Fumagalli; Sara C Kozma; George Thomas
S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway.
Molecular and cellular biology 2004;24(8):3112-24.
2003: Attila Garami; Fried J T Zwartkruis; Takahiro Nobukuni; Manel Joaquin; Marta Roccio; Hugo Stocker; Sara C Kozma; Ernst Hafen; Johannes L Bos; George Thomas
Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2.
Molecular cell 2003;11(6):1457-66.
2002: Satish Patel; Pamela A Lochhead; Graham Rena; Stefano Fumagalli; Mario Pende; Sara C Kozma; George Thomas; Calum Sutherland
Insulin regulation of insulin-like growth factor-binding protein-1 gene expression is dependent on the mammalian target of rapamycin, but independent of ribosomal S6 kinase activity.
The Journal of biological chemistry 2002;277(12):9889-95.
2002: Sara C Kozma; George Thomas
Regulation of cell size in growth, development and human disease: PI3K, PKB and S6K.
BioEssays : news and reviews in molecular, cellular and developmental biology 2002;24(1):65-71.
2001: Patrick B Dennis; Anja Jaeschke; M Saitoh; B Fowler; Sara C Kozma; George Thomas
Mammalian TOR: a homeostatic ATP sensor.
Science (New York, N.Y.) 2001;294(5544):1102-5.
2000: Mario Pende; Sara C Kozma; Muriel Jaquet; Viola Oorschot; Rémy Burcelin; Yannick Le Marchand-Brustel; Judith Klumperman; Bernard Thorens; George Thomas
Hypoinsulinaemia, glucose intolerance and diminished beta-cell size in S6K1-deficient mice.
Nature 2000;408(6815):994-7.
2000: S Volarevic; M J Stewart; B Ledermann; F Zilberman; L Terracciano; Eugenio Montini; Markus Grompe; Sara C Kozma; George Thomas
Proliferation, but not growth, blocked by conditional deletion of 40S ribosomal protein S6.
Science (New York, N.Y.) 2000;288(5473):2045-7.
1999: Jacques Montagne; M J Stewart; Hugo Stocker; Ernst Hafen; Sara C Kozma; George Thomas
Drosophila S6 kinase: a regulator of cell size.
Science (New York, N.Y.) 1999;285(5436):2126-9.
1998: H Shima; Mario Pende; Y Chen; Stefano Fumagalli; George Thomas; Sara C Kozma
Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase.
The EMBO journal 1998;17(22):6649-59.
1998: Patrick B Dennis; Nicholas Pullen; RB Pearson; Sara C Kozma; George Thomas
Phosphorylation sites in the autoinhibitory domain participate in p70(s6k) activation loop phosphorylation.
The Journal of biological chemistry 1998;273(24):14845-52.
1998: F Turck; Sara C Kozma; George Thomas; F Nagy
A heat-sensitive Arabidopsis thaliana kinase substitutes for human p70s6k function in vivo.
Molecular and cellular biology 1998;18(4):2038-44.
1998: Nicholas Pullen; Patrick B Dennis; M Andjelkovic; A Dufner; Sara C Kozma; Brian A Hemmings; George Thomas
Phosphorylation and activation of p70s6k by PDK1.
Science (New York, N.Y.) 1998;279(5351):707-10.
1997: B A Moser; Patrick B Dennis; Nicholas Pullen; RB Pearson; N A Williamson; Richard E H Wettenhall; Sara C Kozma; George Thomas
Dual requirement for a newly identified phosphorylation site in p70s6k.
Molecular and cellular biology 1997;17(9):5648-55.
1996: Patrick B Dennis; Nicholas Pullen; Sara C Kozma; George Thomas
The principal rapamycin-sensitive p70(s6k) phosphorylation sites, T-229 and T-389, are differentially regulated by rapamycin-insensitive kinase kinases.
Molecular and cellular biology 1996;16(11):6242-51.
1996: M J Stewart; C O Berry; F Zilberman; George Thomas; Sara C Kozma
The Drosophila p70s6k homolog exhibits conserved regulatory elements and rapamycin sensitivity.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(20):10791-6.
1995: Richard B Pearson; Patrick B Dennis; J W Han; N A Williamson; Sara C Kozma; Richard E H Wettenhall; George Thomas
The principal target of rapamycin-induced p70s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain.
The EMBO journal 1995;14(21):5279-87.
1994: X F Ming; B M Burgering; S Wennström; L Claesson-Welsh; C H Heldin; J L Bos; Sara C Kozma; George Thomas
Activation of p70/p85 S6 kinase by a pathway independent of p21ras.
Nature 1994;371(6496):426-9.
1994: Sara C Kozma; George Thomas
p70s6k/p85s6k: mechanism of activation and role in mitogenesis.
Seminars in cancer biology 1994;5(4):255-60.
1994: H B Jefferies; C Reinhard; Sara C Kozma; George Thomas
Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(10):4441-5.
1993: S Ferrari; Richard B Pearson; Michel Siegmann; Sara C Kozma; George Thomas
The immunosuppressant rapamycin induces inactivation of p70s6k through dephosphorylation of a novel set of sites.
The Journal of biological chemistry 1993;268(22):16091-4.
1993: Sara C Kozma; E McGlynn; Michel Siegmann; C Reinhard; S Ferrari; George Thomas
Active baculovirus recombinant p70s6k and p85s6k produced as a function of the infectious response.
The Journal of biological chemistry 1993;268(10):7134-8.
1992: C Reinhard; George Thomas; Sara C Kozma
A single gene encodes two isoforms of the p70 S6 kinase: activation upon mitogenic stimulation.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(9):4052-6.
1992: H A Lane; S J Morley; M Dorée; Sara C Kozma; George Thomas
Identification and early activation of a Xenopus laevis p70s6k following progesterone-induced meiotic maturation.
The EMBO journal 1992;11(5):1743-9.
1992: Sara C Kozma; George Thomas
Serine/threonine kinases in the propagation of the early mitogenic response.
Reviews of physiology, biochemistry and pharmacology 1992;119():123-55.
1990: Sara C Kozma; S Ferrari; P Bassand; Michel Siegmann; N Totty; George Thomas
Cloning of the mitogen-activated S6 kinase from rat liver reveals an enzyme of the second messenger subfamily.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(19):7365-9.
1989: Sara C Kozma; H A Lane; S Ferrari; H Luther; Michel Siegmann; George Thomas
A stimulated S6 kinase from rat liver: identity with the mitogen activated S6 kinase of 3T3 cells.
The EMBO journal 1989;8(13):4125-32.
1989: Sara C Kozma; S Ferrari; George Thomas
Unmasking a growth factor/oncogene-activated S6 phosphorylation cascade.
Cellular signalling 1989;1(3):219-25.