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Alois Kozubík

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Radek Fedr; Michal Grepl; Alois Kozubík; Zuzana Pernicová; Eva Slabáková; Jan Bouchal; Nicol Straková; Karel Souček
Automatic cell cloning assay for determining the clonogenic capacity of cancer and cancer stem-like cells.
Markéta Kaucká; Jana Kotasková; Alois Kozubík; Pavel Krejcí; Jirí Mayer; Archana Mishra; Petra Ovesná; Sárka Pavlová; Karla Plevová; Sárka Pospísilová; Jirina Procházková; Boris Tichy; Jan Verner; Yvona Brychtová; Michael Doubek; Pavlína Janovská; Vítezslav Bryja
The planar cell polarity pathway drives pathogenesis of chronic lymphocytic leukemia by the regulation of B-lymphocyte migration.
Zdenek Andrysík; Markéta Kabátková; Jiří Kohoutek; Alois Kozubík; Miroslav Machala; Jiřina Procházková; Pavlína Simečková; Lenka Umannová; Jan Vondráček
Aryl hydrocarbon receptor-mediated disruption of contact inhibition is associated with connexin43 downregulation and inhibition of gap junctional intercellular communication.

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All Publications

2013: Radek Fedr; Michal Grepl; Alois Kozubík; Zuzana Pernicová; Eva Slabáková; Jan Bouchal; Nicol Straková; Karel Souček
Automatic cell cloning assay for determining the clonogenic capacity of cancer and cancer stem-like cells.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2013;83(5):472-82.
2013: Markéta Kaucká; Jana Kotasková; Alois Kozubík; Pavel Krejcí; Jirí Mayer; Archana Mishra; Petra Ovesná; Sárka Pavlová; Karla Plevová; Sárka Pospísilová; Jirina Procházková; Boris Tichy; Jan Verner; Yvona Brychtová; Michael Doubek; Pavlína Janovská; Vítezslav Bryja
The planar cell polarity pathway drives pathogenesis of chronic lymphocytic leukemia by the regulation of B-lymphocyte migration.
Cancer research 2013;73(5):1491-501.
2013: Zdenek Andrysík; Markéta Kabátková; Jiří Kohoutek; Alois Kozubík; Miroslav Machala; Jiřina Procházková; Pavlína Simečková; Lenka Umannová; Jan Vondráček
Aryl hydrocarbon receptor-mediated disruption of contact inhibition is associated with connexin43 downregulation and inhibition of gap junctional intercellular communication.
Archives of toxicology 2013;87(3):491-503.
2012: P Vaňhara; A Hampl; Alois Kozubík; K Souček
Growth/differentiation factor-15: prostate cancer suppressor or promoter?
Prostate cancer and prostatic diseases 2012;15(4):320-8.
2012: Andrea Staršíchová; Jan Vondráček; Eva Hrubá; Markéta Kabátková; Alois Kozubík; Miroslav Machala; Kateřina Pěnčíková; Zuzana Pernicová; Jiřina Procházková; Václav Seda; Eva Slabáková; Karel Souček
TGF-β1 signaling plays a dominant role in the crosstalk between TGF-β1 and the aryl hydrocarbon receptor ligand in prostate epithelial cells.
Cellular signalling 2012;24(8):1665-76.
2012: Jirina Hofmanová; Alois Kozubík; Miroslav Ciganek; Ladislav Dušek; Josef Slavík; Lenka Stixová; Alena Vaculová; Miroslav Machala
Lipid alterations in human colon epithelial cells induced to differentiation and/or apoptosis by butyrate and polyunsaturated fatty acids.
The Journal of nutritional biochemistry 2012;23(6):539-48.
2011: Lenka Umannová; Klára Šujanová; Alois Kozubík; Pavel Krčmář; Miroslav Machala; Jiří Neča; Jana Schmuczerová; Jan Topinka; Jan Vondráček
Benzo[a]pyrene and tumor necrosis factor-α coordinately increase genotoxic damage and the production of proinflammatory mediators in alveolar epithelial type II cells.
Toxicology letters 2011;206(2):121-9.
2011: Zdenek Andrysík; William M Baird; Miroslav Ciganek; Alois Kozubík; Brinda Mahadevan; Sona Marvanová; Jiří Neča; Kateřina Pěnčíková; Jan Topinka; Jan Vondráček; Miroslav Machala
Activation of the aryl hydrocarbon receptor is the major toxic mode of action of an organic extract of a reference urban dust particulate matter mixture: the role of polycyclic aromatic hydrocarbons.
Mutation research 2011;714(1-2):53-62.
2011: Eva Slabáková; Eva Slavíčková; Alois Kozubík; Zuzana Pernicová; Andrea Staršíchová; Karel Souček
TGF-β1-induced EMT of non-transformed prostate hyperplasia cells is characterized by early induction of SNAI2/Slug.
The Prostate 2011;71(12):1332-43.
2011: Jirina Procházková; Lenka Umannová; Ondrej Bernatík; Vítezslav Bryja; Markéta Kabátková; Alois Kozubík; Miroslav Machala; Jan Vondrácek
The interplay of the aryl hydrocarbon receptor and β-catenin alters both AhR-dependent transcription and Wnt/β-catenin signaling in liver progenitors.
Toxicological sciences : an official journal of the Society of Toxicology 2011;122(2):349-60.
2011: Lenka Kočí; Martina Hýžd'alová; Alena Vaculová; Jirina Hofmanová; Alois Kozubík
Detachment-mediated resistance to TRAIL-induced apoptosis is associated with stimulation of the PI3K/Akt pathway in fetal and adenocarcinoma epithelial colon cells.
Cytokine 2011;55(1):34-9.
2011: Zuzana Pernicová; Eva Slabáková; Jan Bouchal; Gvantsa Kharaishvili; Alois Kozubík; Milan Král; Zuzana Kunická; Miroslav Machala; Karel Souček
Androgen depletion induces senescence in prostate cancer cells through down-regulation of Skp2.
Neoplasia (New York, N.Y.) 2011;13(6):526-36.
2011: Jaromír Mikeš; Martina Hýžďalová; Lenka Kočí; Rastislav Jendželovský; Ján Kovaľ; Alena Vaculová; Jirina Hofmanová; Alois Kozubík; Peter Fedoročko
Lower sensitivity of FHC fetal colon epithelial cells to photodynamic therapy compared to HT-29 colon adenocarcinoma cells despite higher intracellular accumulation of hypericin.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 2011;10(4):626-32.
2011: Jiřina Procházková; Alois Kozubík; Miroslav Machala; Jan Vondráček
Differential effects of indirubin and 2,3,7,8-tetrachlorodibenzo-p-dioxin on the aryl hydrocarbon receptor (AhR) signalling in liver progenitor cells.
Toxicology 2011;279(1-3):146-54.
2011: Olga Vondálová Blanárová; Iva Jelínková; Arpád Szöor; Belma Skender; Karel Soucek; Viktor Horváth; Alena Vaculová; Ladislav Andera; Petr Sova; János Szöllosi; Jirina Hofmanová; György Vereb; Alois Kozubík
Cisplatin and a potent platinum(IV) complex-mediated enhancement of TRAIL-induced cancer cells killing is associated with modulation of upstream events in the extrinsic apoptotic pathway.
Carcinogenesis 2011;32(1):42-51.
2011: Igor Červenka; Joshua Wolf; Jan Mašek; Pavel Krejci; William R Wilcox; Alois Kozubík; Gunnar Schulte; J Silvio Gutkind; Vítezslav Bryja
Mitogen-activated protein kinases promote WNT/beta-catenin signaling via phosphorylation of LRP6.
Molecular and cellular biology 2011;31(1):179-89.
2010: Karel Soucek; Eva Slabáková; Petra Ovesná; Alice Malenovská; Alois Kozubík; Ales Hampl
Growth/differentiation factor-15 is an abundant cytokine in human seminal plasma.
Human reproduction (Oxford, England) 2010;25(12):2962-71.
2010: Andrea Starsíchová; Eva Lincová; Zuzana Pernicová; Alois Kozubík; Karel Soucek
TGF-beta1 suppresses IL-6-induced STAT3 activation through regulation of Jak2 expression in prostate epithelial cells.
Cellular signalling 2010;22(11):1734-44.
2010: Lenka Švihálková-Šindlerová; Vendula Foltinová; Alena Vaculová; Viktor Horváth; Karel Soucek; Petr Sova; Jirina Hofmanová; Alois Kozubík
LA-12 overcomes confluence-dependent resistance of HT-29 colon cancer cells to Pt (II) compounds.
Anticancer research 2010;30(4):1183-8.
2010: Karel Soucek; Pavla Gajdusková; Marie Brázdová; Martina Hýzd'alová; Lenka Kocí; David Vydra; Radek Trojanec; Zuzana Pernicová; Lenka Lentvorská; Marián Hajdúch; Jirina Hofmanová; Alois Kozubík
Fetal colon cell line FHC exhibits tumorigenic phenotype, complex karyotype, and TP53 gene mutation.
Cancer genetics and cytogenetics 2010;197(2):107-16.
2010: Silvie Foldynová-Trantírková; Petra Sekyrová; Katerina Tmejová; Eva Brumovská; Ondrej Bernatík; Wulf Blankenfeldt; Pavel Krejcí; Alois Kozubík; Tomás Dolezal; Lukás Trantírek; Vítezslav Bryja
Breast cancer-specific mutations in CK1epsilon inhibit Wnt/beta-catenin and activate the Wnt/Rac1/JNK and NFAT pathways to decrease cell adhesion and promote cell migration.
Breast cancer research : BCR 2010;12(3):R30.
2009: Rastislav Jendzelovský; Jaromir Mikes; Ján Koval'; Karel Soucek; Jirina Procházková; Martin Kello; Veronika Sacková; Jirina Hofmanová; Alois Kozubík; Peter Fedorocko
Drug efflux transporters, MRP1 and BCRP, affect the outcome of hypericin-mediated photodynamic therapy in HT-29 adenocarcinoma cells.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 2009;8(12):1716-23.
2009: Alena Vaculová; Jirina Hofmanová; Jirina Zatloukalová; Alois Kozubík
Differences in TRAIL-induced changes of Mcl-1 expression among distinct human colon epithelial cell lines.
Experimental cell research 2009;315(19):3259-66.
2009: Petr Vanhara; Eva Lincová; Alois Kozubík; Pierre Jurdic; Karel Soucek; Jan Smarda
Growth/differentiation factor-15 inhibits differentiation into osteoclasts--a novel factor involved in control of osteoclast differentiation.
Differentiation; research in biological diversity 2009;78(4):213-22.
2009: Lenka Stixová; Jirina Procházková; Karel Soucek; Jirina Hofmanová; Alois Kozubík
5-Lipoxygenase inhibitors potentiate 1alpha,25-dihydroxyvitamin D3-induced monocytic differentiation by activating p38 MAPK pathway.
Molecular and cellular biochemistry 2009;330(1-2):229-38.
2009: Eva Lincová; Ales Hampl; Zuzana Pernicová; Andrea Starsíchová; Pavel Krcmár; Miroslav Machala; Alois Kozubík; Karel Soucek
Multiple defects in negative regulation of the PKB/Akt pathway sensitise human cancer cells to the antiproliferative effect of non-steroidal anti-inflammatory drugs.
Biochemical pharmacology 2009;78(6):561-72.
2009: Jan Vondrácek; Pavel Krcmár; Jirina Procházková; Lenka Trilecová; Martina Gavelová; Lenka Skálová; Barbora Szotáková; Martin Buncek; Hana Radilová; Alois Kozubík; Miroslav Machala
The role of aryl hydrocarbon receptor in regulation of enzymes involved in metabolic activation of polycyclic aromatic hydrocarbons in a model of rat liver progenitor cells.
Chemico-biological interactions 2009;180(2):226-37.
2009: Jirina Procházková; Lenka Stixová; Karel Soucek; Jirina Hofmanová; Alois Kozubík
Monocytic differentiation of leukemic HL-60 cells induced by co-treatment with TNF-alpha and MK886 requires activation of pro-apoptotic machinery.
European journal of haematology 2009;83(1):35-47.
2009: P Simecková; Jan Vondrácek; J Procházková; Alois Kozubík; P Krcmár; Miroslav Machala
2,2',4,4',5,5'-hexachlorobiphenyl (PCB 153) induces degradation of adherens junction proteins and inhibits beta-catenin-dependent transcription in liver epithelial cells.
Toxicology 2009;260(1-3):104-11.
2009: Jirina Hofmanová; Alena Vaculová; Zuzana Koubková; Martina Hýzd'alová; Alois Kozubík
Human fetal colon cells and colon cancer cells respond differently to butyrate and PUFAs.
Molecular nutrition & food research 2009;53 Suppl 1():S102-13.
2009: Andrea Staršíchová; Lukáš Kubala; Eva Lincová; Zuzana Pernicová; Alois Kozubík; Karel Souček
Dynamic Monitoring of Cellular Remodeling Induced by the Transforming Growth Factor-β1.
Biological procedures online 2009;11():316-24.
2008: Ján Kleban; Jaromir Mikes; Viktor Horváth; Veronika Sacková; Jirina Hofmanová; Alois Kozubík; Peter Fedorocko
Mechanisms involved in the cell cycle and apoptosis of HT-29 cells pre-treated with MK-886 prior to photodynamic therapy with hypericin.
Journal of photochemistry and photobiology. B, Biology 2008;93(2):108-18.
2008: M Hýzd'alová; Jirina Hofmanová; J Pacherník; Alena Vaculová; Alois Kozubík
The interaction of butyrate with TNF-alpha during differentiation and apoptosis of colon epithelial cells: role of NF-kappaB activation.
Cytokine 2008;44(1):33-43.
2008: Miroslav Machala; Lenka Švihálková-Šindlerová; K Pencíková; P Krcmár; Jan Topinka; A Milcová; Z Nováková; Alois Kozubík; Jan Vondrácek
Effects of methylated chrysenes on AhR-dependent and -independent toxic events in rat liver epithelial cells.
Toxicology 2008;247(2-3):93-101.
2008: L Umannová; J Neca; Z Andrysík; Jan Vondrácek; B L Upham; James E Trosko; Jirina Hofmanová; Alois Kozubík; Miroslav Machala
Non-dioxin-like polychlorinated biphenyls induce a release of arachidonic acid in liver epithelial cells: a partial role of cytosolic phospholipase A(2) and extracellular signal-regulated kinases 1/2 signalling.
Toxicology 2008;247(1):55-60.
2008: Lenka Umannová; Miroslav Machala; Jan Topinka; Zuzana Nováková; Alena Milcová; Alois Kozubík; Jan Vondrácek
Tumor necrosis factor-alpha potentiates genotoxic effects of benzo[a]pyrene in rat liver epithelial cells through upregulation of cytochrome P450 1B1 expression.
Mutation research 2008;640(1-2):162-9.
2008: Jirina Hofmanová; Alena Vaculová; Martina Hyzd'alová; Alois Kozubík
Response of normal and colon cancer epithelial cells to TNF-family apoptotic inducers.
Oncology reports 2008;19(2):567-73.
2008: Alois Kozubík; Alena Vaculová; Karel Soucek; Jan Vondrácek; Jaroslav Turánek; Jirina Hofmanová
Novel Anticancer Platinum(IV) Complexes with Adamantylamine: Their Efficiency and Innovative Chemotherapy Strategies Modifying Lipid Metabolism.
Metal-based drugs 2008;2008():417897.
2007: Jan Vondrácek; Lenka Švihálková-Šindlerová; Katerina Pencíková; Sona Marvanová; Pavel Krcmár; Miroslav Ciganek; Jirí Neca; James E Trosko; Brad L Upham; Alois Kozubík; Miroslav Machala
Concentrations of methylated naphthalenes, anthracenes, and phenanthrenes occurring in Czech river sediments and their effects on toxic events associated with carcinogenesis in rat liver cell lines.
Environmental toxicology and chemistry / SETAC 2007;26(11):2308-16.
2007: Viktor Horváth; Karel Soucek; Lenka Švihálková-Šindlerová; Jan Vondrácek; Olga Blanárová; Jirina Hofmanová; Petr Sova; Alois Kozubík
Different cell cycle modulation following treatment of human ovarian carcinoma cells with a new platinum(IV) complex vs cisplatin.
Investigational new drugs 2007;25(5):435-43.
2007: Denisa Streitová; Lenka Weiterová; Michal Hofer; Jirina Holá; Viktor Horváth; Alois Kozubík; Vladimír Znojil
Effect of adenosine on the growth of human T-lymphocyte leukemia cell line MOLT-4.
Cancer investigation 2007;25(6):419-26.
2007: Ján Kleban; Jaromir Mikes; Beáta Szilárdiová; Ján Kovaľ; Veronika Sacková; Peter Solár; Viktor Horváth; Jirina Hofmanová; Alois Kozubík; Peter Fedorocko
Modulation of hypericin photodynamic therapy by pretreatment with 12 various inhibitors of arachidonic acid metabolism in colon adenocarcinoma HT-29 cells.
Photochemistry and photobiology 2007;83(5):1174-85.
2007: Lenka Umannová; Jirina Zatloukalová; Miroslav Machala; Pavel Krcmár; Zuzana Májková; Bernhard Hennig; Alois Kozubík; Jan Vondrácek
Tumor necrosis factor-alpha modulates effects of aryl hydrocarbon receptor ligands on cell proliferation and expression of cytochrome P450 enzymes in rat liver "stem-like" cells.
Toxicological sciences : an official journal of the Society of Toxicology 2007;99(1):79-89.
2007: Jarmila Navrátilová; Viktor Horváth; Alois Kozubík; Antonín Lojek; Joseph Lipsick; Jan Smarda
p53 arrests growth and induces differentiation of v-Myb-transformed monoblasts.
Differentiation; research in biological diversity 2007;75(7):592-604.
2007: Jaromir Mikes; Ján Kleban; Veronika Sacková; Viktor Horváth; Erika Jamborová; Alena Vaculová; Alois Kozubík; Jirina Hofmanová; Peter Fedorocko
Necrosis predominates in the cell death of human colon adenocarcinoma HT-29 cells treated under variable conditions of photodynamic therapy with hypericin.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 2007;6(7):758-66.
2007: Lubomír Procházka; Jaroslav Turánek; Radek Tesarík; Pavlína Knotigová; Pavlína Polásková; Zdenek Andrysík; Alois Kozubík; Frantisek Zák; Petr Sova; Jiri Neuzil; Miroslav Machala
Apoptosis and inhibition of gap-junctional intercellular communication induced by LA-12, a novel hydrophobic platinum(IV) complex.
Archives of biochemistry and biophysics 2007;462(1):54-61.
2007: Jirina Zatloukalová; Lenka Švihálková-Šindlerová; Alois Kozubík; Pavel Krcmár; Miroslav Machala; Jan Vondrácek
beta-Naphthoflavone and 3'-methoxy-4'-nitroflavone exert ambiguous effects on Ah receptor-dependent cell proliferation and gene expression in rat liver 'stem-like' cells.
Biochemical pharmacology 2007;73(10):1622-34.
2007: Eva Bártová; Jirí Pacherník; Alois Kozubík; Stanislav Kozubek
Differentiation-specific association of HP1alpha and HP1beta with chromocentres is correlated with clustering of TIF1beta at these sites.
Histochemistry and cell biology 2007;127(4):375-88.
2007: Lenka Švihálková-Šindlerová; Miroslav Machala; Katerina Pencíková; Sona Marvanová; Jirí Neca; Jan Topinka; Oksana Sevastyanova; Alois Kozubík; Jan Vondrácek
Dibenzanthracenes and benzochrysenes elicit both genotoxic and nongenotoxic events in rat liver 'stem-like' cells.
Toxicology 2007;232(1-2):147-59.
2007: Zdenek Andrysík; Jan Vondrácek; Miroslav Machala; Pavel Krcmár; Lenka Švihálková-Šindlerová; Anne Kranz; Carsten Weiss; Dagmar Faust; Alois Kozubík; Cornelia Dietrich
The aryl hydrocarbon receptor-dependent deregulation of cell cycle control induced by polycyclic aromatic hydrocarbons in rat liver epithelial cells.
Mutation research 2007;615(1-2):87-97.
2007: Petr Vanhara; Vítezslav Bryja; Viktor Horváth; Alois Kozubík; Ales Hampl; Jan Smarda
c-Jun induces apoptosis of starved BM2 monoblasts by activating cyclin A-CDK2.
Biochemical and biophysical research communications 2007;353(1):92-7.
2007: Jirí Pacherník; Viktor Horváth; Lukas Kubala; Petr Dvorák; Alois Kozubík; Ales Hampl
Neural differentiation potentiated by the leukaemia inhibitory factor through STAT3 signalling in mouse embryonal carcinoma cells.
Folia biologica 2007;53(5):157-63.
2007: Peter Solár; Viktor Horváth; Ján Kovaľ; J Koval'; Z Solárová; Alois Kozubík; Peter Fedorocko
Hsp90 inhibitor geldanamycin increases the sensitivity of resistant ovarian adenocarcinoma cell line A2780cis to cisplatin.
Neoplasma 2007;54(2):127-30.
2006: Alena Vaculová; Jirina Hofmanová; Karel Soucek; Alois Kozubík
Different modulation of TRAIL-induced apoptosis by inhibition of pro-survival pathways in TRAIL-sensitive and TRAIL-resistant colon cancer cells.
FEBS letters 2006;580(28-29):6565-9.
2006: Michal Hofer; Milan Pospísil; Vladimír Znojil; Jirina Holá; Antonín Vacek; Lenka Weiterová; Denisa Streitová; Alois Kozubík
Meloxicam, a cyclooxygenase 2 inhibitor, supports hematopoietic recovery in gamma-irradiated mice.
Radiation research 2006;166(3):556-60.
2006: Ján Kleban; Beáta Szilárdiová; Jaromir Mikes; Viktor Horváth; Veronika Sacková; Peter Brezáni; Jirina Hofmanová; Alois Kozubík; Peter Fedorocko
Pre-treatment of HT-29 cells with 5-LOX inhibitor (MK-886) induces changes in cell cycle and increases apoptosis after photodynamic therapy with hypericin.
Journal of photochemistry and photobiology. B, Biology 2006;84(2):79-88.
2006: Viktor Horváth; Olga Blanárová; Lenka Švihálková-Šindlerová; Karel Soucek; Jirina Hofmanová; Petr Sova; Ales Kroutil; Peter Fedorocko; Alois Kozubík
Platinum(IV) complex with adamantylamine overcomes intrinsic resistance to cisplatin in ovarian cancer cells.
Gynecologic oncology 2006;102(1):32-40.
2006: Jirí Stika; Jan Vondrácek; Jirina Hofmanová; Vladimír Simek; Alois Kozubík
MK-886 enhances tumour necrosis factor-alpha-induced differentiation and apoptosis.
Cancer letters 2006;237(2):263-71.
2006: Karel Soucek; Jirí Pacherník; Lukas Kubala; Jan Vondrácek; Jirina Hofmanová; Alois Kozubík
Transforming growth factor-beta1 inhibits all-trans retinoic acid-induced apoptosis.
Leukemia research 2006;30(5):607-23.
2006: Jan Vondrácek; Lenka Švihálková-Šindlerová; Katerina Pencíková; Pavel Krcmár; Zdenek Andrysík; Katerina Chramostová; Sona Marvanová; Zuzana Valovicová; Alois Kozubík; Alena Gábelová; Miroslav Machala
7H-Dibenzo[c,g]carbazole and 5,9-dimethyldibenzo[c,g]carbazole exert multiple toxic events contributing to tumor promotion in rat liver epithelial 'stem-like' cells.
Mutation research 2006;596(1-2):43-56.
2006: Zdenek Andrysík; Miroslav Machala; Katerina Chramostová; Jirina Hofmanová; Alois Kozubík; Jan Vondrácek
Activation of ERK1/2 and p38 kinases by polycyclic aromatic hydrocarbons in rat liver epithelial cells is associated with induction of apoptosis.
Toxicology and applied pharmacology 2006;211(3):198-208.
2006: Jan Vondrácek; Karel Soucek; Michael A Sheard; Katerina Chramostová; Zdenek Andrysík; Jirina Hofmanová; Alois Kozubík
Dimethyl sulfoxide potentiates death receptor-mediated apoptosis in the human myeloid leukemia U937 cell line through enhancement of mitochondrial membrane depolarization.
Leukemia research 2006;30(1):81-9.
2005: Alena Vaculová; Jirina Hofmanová; Ladislav Andera; Alois Kozubík
TRAIL and docosahexaenoic acid cooperate to induce HT-29 colon cancer cell death.
Cancer letters 2005;229(1):43-8.
2005: Alois Kozubík; Viktor Horváth; Lenka Švihálková-Šindlerová; Karel Soucek; Jirina Hofmanová; Petr Sova; Ales Kroutil; Frantisek Zák; Adolf Mistr; Jaroslav Turánek
High effectiveness of platinum(IV) complex with adamantylamine in overcoming resistance to cisplatin and suppressing proliferation of ovarian cancer cells in vitro.
Biochemical pharmacology 2005;69(3):373-83.
2005: Martina Plísková; Jan Vondrácek; Borivoj Vojtesek; Alois Kozubík; Miroslav Machala
Deregulation of cell proliferation by polycyclic aromatic hydrocarbons in human breast carcinoma MCF-7 cells reflects both genotoxic and nongenotoxic events.
Toxicological sciences : an official journal of the Society of Toxicology 2005;83(2):246-56.
2005: Jirina Hofmanová; Alena Vaculová; Antonín Lojek; Alois Kozubík
Interaction of polyunsaturated fatty acids and sodium butyrate during apoptosis in HT-29 human colon adenocarcinoma cells.
European journal of nutrition 2005;44(1):40-51.
2005: Jirina Hofmanová; Alena Vaculová; Alois Kozubík
Polyunsaturated fatty acids sensitize human colon adenocarcinoma HT-29 cells to death receptor-mediated apoptosis.
Cancer letters 2005;218(1):33-41.
2005: Jirina Hofmanová; Zdenek Zadák; Radomír Hyspler; J Mikeska; P Zdánský; Alena Vaculová; J Netíková; Alois Kozubík
The effects of parenteral lipid emulsions on cancer and normal human colon epithelial cells in vitro.
Physiological research / Academia Scientiarum Bohemoslovaca 2005;54(4):409-18.
2005: Jan Vondrácek; Miroslav Machala; Vítezslav Bryja; Katerina Chramostová; Pavel Krcmár; Cornelia Dietrich; Ales Hampl; Alois Kozubík
Aryl hydrocarbon receptor-activating polychlorinated biphenyls and their hydroxylated metabolites induce cell proliferation in contact-inhibited rat liver epithelial cells.
Toxicological sciences : an official journal of the Society of Toxicology 2005;83(1):53-63.
2004: Alena Vaculová; Jirina Hofmanová; Karel Soucek; Ladislav Andera; Alois Kozubík
Ethanol acts as a potent agent sensitizing colon cancer cells to the TRAIL-induced apoptosis.
FEBS letters 2004;577(1-2):309-13.
2004: Jan Vondrácek; Katerina Chramostová; Martina Plísková; Ludek Bláha; Werner Brack; Alois Kozubík; Miroslav Machala
Induction of aryl hydrocarbon receptor-mediated and estrogen receptor-mediated activities, and modulation of cell proliferation by dinaphthofurans.
Environmental toxicology and chemistry / SETAC 2004;23(9):2214-20.
2004: Jaroslav Turánek; Andrea Kasná; Dana Záluská; Jirí Neca; Veronika Kvardová; Pavlína Knötigová; Viktor Horváth; Lenka Švihálková-Šindlerová; Alois Kozubík; Petr Sova; Ales Kroutil; Frantisek Zák; Adolf Mistr
New platinum(IV) complex with adamantylamine ligand as a promising anti-cancer drug: comparison of in vitro cytotoxic potential towards A2780/cisR cisplatin-resistant cell line within homologous series of platinum(IV) complexes.
Anti-cancer drugs 2004;15(5):537-43.
2004: Katerina Chramostová; Jan Vondrácek; Lenka Švihálková-Šindlerová; Borivoj Vojtesek; Alois Kozubík; Miroslav Machala
Polycyclic aromatic hydrocarbons modulate cell proliferation in rat hepatic epithelial stem-like WB-F344 cells.
Toxicology and applied pharmacology 2004;196(1):136-48.
2004: Martina Kovaríková; Jirina Hofmanová; Karel Soucek; Alois Kozubík
The effects of TNF-alpha and inhibitors of arachidonic acid metabolism on human colon HT-29 cells depend on differentiation status.
Differentiation; research in biological diversity 2004;72(1):23-31.
2004: Frantisek Zák; Jaroslav Turánek; Ales Kroutil; Petr Sova; Adolf Mistr; Anna Poulová; Petr Mikolin; Zdirad Zák; Andrea Kasná; Dana Záluská; Jirí Neca; Lenka Švihálková-Šindlerová; Alois Kozubík
Platinum(IV) complex with adamantylamine as nonleaving amine group: synthesis, characterization, and in vitro antitumor activity against a panel of cisplatin-resistant cancer cell lines.
Journal of medicinal chemistry 2004;47(3):761-3.
2003: Vítezslav Bryja; Jirí Sedlácek; Eva Zahradnícková; Sabina Sevcíková; Jirí Pacherník; Karel Soucek; Jirina Hofmanová; Alois Kozubík; Jan Smarda
Lipoxygenase inhibitors enhance tumor suppressive effects of jun proteins on v-myb-transformed monoblasts BM2.
Prostaglandins & other lipid mediators 2003;72(3-4):131-45.
2003: Jirí Fajkus; Marek Borsky; Zuzana Kunická; Martina Kovaríková; Dana Dvoráková; Jirina Hofmanová; Alois Kozubík
Changes in telomerase activity, expression and splicing in response to differentiation of normal and carcinoma colon cells.
Anticancer research 2003;23(2B):1605-12.
2003: Zuzana Hoferová; Peter Fedorocko; Michal Hofer; Jirina Hofmanová; Alois Kozubík; V Eliásová
Lipoxygenase inhibitors suppress proliferation of G5:113 fibrosarcoma cells in vitro but they have no anticancer activity in vivo.
Neoplasma 2003;50(2):102-9.
2002: Jan Vondrácek; Alois Kozubík; Miroslav Machala
Modulation of estrogen receptor-dependent reporter construct activation and G0/G1-S-phase transition by polycyclic aromatic hydrocarbons in human breast carcinoma MCF-7 cells.
Toxicological sciences : an official journal of the Society of Toxicology 2002;70(2):193-201.
2002: Peter Solár; Ivan Cavarga; Jirina Hofmanová; Mária Cekanová-Figurová; Pavol Miskovský; Peter Brezáni; Gabriela Hrcková; Alois Kozubík; Peter Fedorocko
Effect of acetazolamide on hypericin photocytotoxicity.
Planta medica 2002;68(7):658-60.
2002: Alena Vaculová; Jirina Hofmanova; Karel Soucek; Martina Kovariková; Alois Kozubík
Tumor necrosis factor-alpha induces apoptosis associated with poly(ADP-ribose) polymerase cleavage in HT-29 colon cancer cells.
Anticancer research 2002;22(3):1635-9.
2002: Jirí Pacherník; Ales Hampl; Karel Soucek; Martina Kovaríková; Zdenek Andrysík; Jirina Hofmanová; Alois Kozubík
Multiple biological effects of inhibitors of arachidonic acid metabolism on human keratinocytes.
Archives of dermatological research 2002;293(12):626-33.
2002: Jirina Hofmanová; Karel Soucek; Jirí Pacherník; Martina Kovaríková; Zuzana Hoferová; Katerina Minksová; J Netíková; Alois Kozubík
Lipoxygenase inhibitors induce arrest of tumor cells in S-phase of the cell cycle.
Neoplasma 2002;49(6):362-7.
2002: Jirí Pacherník; R Janík; Jirina Hofmanová; Vítezslav Bryja; Alois Kozubík
Conditions for gene transfection into the HL-60 human leukaemia cell line by electroporation.
Folia biologica 2002;48(4):154-6.
2002: Zuzana Hoferová; Peter Fedorocko; Jirina Hofmanová; Michal Hofer; Vladimír Znojil; Katerina Minksová; Karel Soucek; Alena Egyed; Alois Kozubík
The effect of nonsteroidal antiinflammatory drugs ibuprofen, flurbiprofen, and diclofenac on in vitro and in vivo growth of mouse fibrosarcoma.
Cancer investigation 2002;20(4):490-8.
2001: Jan Vondrácek; J Stika; Karel Soucek; Katerina Minksová; Ludek Bláha; Jirina Hofmanová; Alois Kozubík
Inhibitors of arachidonic acid metabolism potentiate tumour necrosis factor-alpha-induced apoptosis in HL-60 cells.
European journal of pharmacology 2001;424(1):1-11.
2001: Jan Vondrácek; Miroslav Machala; Katerina Minksová; Ludek Bláha; A J Murk; Alois Kozubík; Jirina Hofmanová; Klára Hilscherová; Robert Ulrich; Miroslav Ciganek; Jirí Neca; D Svrcková; Ivan Holoubek
Monitoring river sediments contaminated predominantly with polyaromatic hydrocarbons by chemical and in vitro bioassay techniques.
Environmental toxicology and chemistry / SETAC 2001;20(7):1499-506.
2001: Jan Vondrácek; M A Sheard; P Krejcí; Katerina Minksová; Jirina Hofmanová; Alois Kozubík
Modulation of death receptor-mediated apoptosis in differentiating human myeloid leukemia HL-60 cells.
Journal of leukocyte biology 2001;69(5):794-802.
2001: Jirí Pacherník; Karel Soucek; Ales Hampl; Jirina Hofmanová; Alois Kozubík
Transforming growth factor-beta1 induces junB mRNA accumulation, G1-phase arrest, and pRb dephosphorylation in human leukemia HL-60 cells.
Folia biologica 2001;47(1):32-5.
2000: Martina Kovaríková; Jirí Pacherník; Jirina Hofmanová; Zdenek Zadák; Alois Kozubík
TNF-alpha modulates the differentiation induced by butyrate in the HT-29 human colon adenocarcinoma cell line.
European journal of cancer (Oxford, England : 1990) 2000;36(14):1844-52.
2000: Jan Zaloudík; O Coufal; I Kocáková; Alois Kozubík; Jirina Hofmanová
Chemoprevention of colorectal carcinoma in high-risk patients.
Acta Universitatis Palackianae Olomucensis Facultatis Medicae 2000;143():109.
2000: Jirina Hofmanová; Karel Soucek; L Dusek; J Netíková; Alois Kozubík
Inhibition of the cytochrome P-450 modulates all-trans-retinoic acid-induced differentiation and apoptosis of HL-60 cells.
Cancer detection and prevention 2000;24(4):325-42.
2000: Jirina Hofmanová; Miroslav Machala; Alois Kozubík
Epigenetic mechanisms of the carcinogenic effects of xenobiotics and in vitro methods of their detection.
Folia biologica 2000;46(5):165-73.
1999: Jan Smarda; K Zemanová; J Bryja; Jana Smardová; Alois Kozubík; Jirina Hofmanová; Alice Nemajerová; Sabina Sevcíková; Jirí Kohoutek; Petr Vodicka
Retinoid X receptor suppresses transformation by the v-myb oncogene.
Journal of leukocyte biology 1999;66(6):1039-48.
1998: Jirina Hofmanová; Alois Kozubík; L Dusek; Jirí Pacherník
Inhibitors of lipoxygenase metabolism exert synergistic effects with retinoic acid on differentiation of human leukemia HL-60 cells.
European journal of pharmacology 1998;350(2-3):273-84.
1997: Alois Kozubík; Jirina Hofmanová; L Dusek; E Musilová
5-Lipoxygenase inhibitors potentiate effects of TGF-beta 1 on the differentiation of human leukemia HL-60 cells.
Journal of leukocyte biology 1997;62(2):240-8.
1996: Alois Kozubík; Jirina Hofmanová; L Dusek
Eicosanoid inhibitors enhance synergistically the effect of transforming growth factor beta 1 on CCL 64 cell proliferation.
European journal of pharmacology 1996;316(2-3):349-57.
1996: Jirina Hofmanová; E Musilová; Alois Kozubík
Suppression of human cancer cell proliferation by lipoxygenase inhibitors and gamma-radiation in vitro.
General physiology and biophysics 1996;15(4):317-31.
1994: Alois Kozubík; Jirina Hofmanová; Milan Pospísil; J Netíková; Jirina Holá; Antonín Lojek
Effects of drugs inhibiting prostaglandin or leukotriene biosynthesis on postirradiation haematopoiesis in mouse.
International journal of radiation biology 1994;65(3):369-77.
1993: Antonín Lojek; Alois Kozubík; Milan Cíz; Jirina Hofmanová
Effects of nordihydroguaiaretic acid on the chemiluminescence of murine phagocytes.
General physiology and biophysics 1993;12(4):349-55.
1993: Alois Kozubík; Jirina Hofmanová; Jirina Holá; J Netíková
The effect of nordihydroguaiaretic acid, an inhibitor of prostaglandin and leukotriene biosynthesis, on hematopoiesis of gamma-irradiated mice.
Experimental hematology 1993;21(1):138-42.
1992: K Volenec; Milan Pospísil; J Netíková; J Pipalová; Alois Kozubík
Enhancement of hypoxia radioprotection and decrease of hypoxia toxicity caused by adenosine monophosphate.
Sborník vědeckých prací Lékařské fakulty Karlovy university v Hradci Králové 1992;35(3):263-74.
1991: Alois Kozubík; Milan Pospísil; J Netíková
Possibilities of the combined use of non-steroidal anti-inflammatory drugs and sulfhydryl compounds in radioprotection.
Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al] 1991;167(3):186-90.
1990: Milan Pospísil; J Netiková; I Pipalová; Alois Kozubík
Therapeutic effects of the joint administration of magnesium aspartate and adenosine monophosphate in gamma irradiated mice.
Radiobiologia, radiotherapia 1990;31(3):273-8.
1990: Alois Kozubík; Milan Pospísil; J Netíková
Enhancement of haemopoietic recovery in sublethally gamma-irradiated mice by the joint use of indomethacin and cystamine.
Folia biologica 1990;36(6):291-300.
1989: Milan Pospísil; J Netíková; Alois Kozubík; I Pipalová
Effect of indomethacin, diclofenac sodium and sodium salicylate on peripheral blood cell counts in sublethally gamma-irradiated mice.
Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al] 1989;165(8):627-31.
1988: Alois Kozubík; A Sedláková; Milan Pospísil; R Petrásek
In vivo studies of the relationship between the activation of lipid metabolism, postirradiation bone marrow cell proliferation and radioresistance of mice.
General physiology and biophysics 1988;7(3):293-302.
1988: Milan Pospísil; J Netiková; Alois Kozubík; K S Chertkov
Enhancement of radioprotective effectiveness of adenosine monophosphate by magnesium aspartate in mice.
Radiobiologia, radiotherapia 1988;29(1):101-8.
1988: Jirí Vácha; J Mikeska; Vladimír Znojil; Milan Pospísil; Jirina Holá; Alois Kozubík; B Hosek
The fall in the incorporation of labelled iron into the bone marrow during enhanced erythropoiesis: this paradox explained by changes in ferrokinetics and cytokinetics using the model of mice affected by thyroid hormones.
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology 1988;15(4):373-80.
1987: Alois Kozubík; Milan Pospísil; S Viklická; L Tkadlecek; J Netíková
Effect of indomethacin on the proliferative and differentiation activity in the haemopoietic system of lethally irradiated mice after syngeneic bone marrow transplantation.
Folia biologica 1987;33(6):418-23.
1986: Milan Pospísil; J Netíková; Alois Kozubík
Enhancement of hemopoietic recovery by indomethacin after sublethal whole-body gamma irradiation.
Acta radiologica. Oncology 1986;25(3):195-8.
1985: Alois Kozubík; Milan Pospísil; B Hosek
Stimulatory effect of intermittent feeding on hemopoietic recovery in sublethally gamma-irradiated mice.
Acta radiologica. Oncology 1985;24(2):199-204.
1985: Milan Pospísil; J Netíková; Alois Kozubík; I Pipalová; L Tkadlecek; S Viklická
Late effects of total-head gamma irradiation in mice. 1. Observations on mortality, body weight changes and bone-marrow hemopoiesis.
Radiobiologia, radiotherapia 1985;26(4):469-76.
1981: Milan Pospísil; J Netíková; Alois Kozubík
Comparison of cell proliferation in the regenerating bone marrow and spleen of irradiated mice with the use of 125I-iododeoxyuridine.
Acta radiologica. Oncology 1981;20(6):373-8.