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James Krahenbuhl

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Ramanuj Lahiri; Baljit Randhawa; John S Spencer; Malcolm S Duthie; Kees L M C Franken; Annemieke Geluk; James L Krahenbuhl
Development of a mouse food pad model for detection of sub clinical leprosy.
Ramanuj Lahiri; Baljit Randhawa; James L Krahenbuhl
Infection of mouse macrophages with viable Mycobacterium leprae does not induce apoptosis.
Daniel Sinsimer; Dorothy Fallows; Blas Peixoto; James L Krahenbuhl; Gilla Kaplan; Claudia Manca
Mycobacterium leprae actively modulates the cytokine response in naive human monocytes.

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All Publications

2011: Ramanuj Lahiri; Baljit Randhawa; John S Spencer; Malcolm S Duthie; Kees L M C Franken; Annemieke Geluk; James L Krahenbuhl
Development of a mouse food pad model for detection of sub clinical leprosy.
Leprosy review 2011;82(4):432-44.
2010: Ramanuj Lahiri; Baljit Randhawa; James L Krahenbuhl
Infection of mouse macrophages with viable Mycobacterium leprae does not induce apoptosis.
The Journal of infectious diseases 2010;201(11):1736-42.
2010: Daniel Sinsimer; Dorothy Fallows; Blas Peixoto; James L Krahenbuhl; Gilla Kaplan; Claudia Manca
Mycobacterium leprae actively modulates the cytokine response in naive human monocytes.
Infection and immunity 2010;78(1):293-300.
2009: Deanna A Hagge; Bernadette M Saunders; Gigi Ebenezer; Nashone A Ray; Vilma T Marks; Warwick J Britton; James L Krahenbuhl; Linda B Adams
Lymphotoxin-alpha and TNF have essential but independent roles in the evolution of the granulomatous response in experimental leprosy.
The American journal of pathology 2009;174(4):1379-89.
2008: Ramanuj Lahiri; James L Krahenbuhl
The role of free-living pathogenic amoeba in the transmission of leprosy: a proof of principle.
Leprosy review 2008;79(4):401-9.
2008: Ramanuj Lahiri; Felipe G Sandoval; James L Krahenbuhl; EJ Shannon
Activation of complement by Mycobacterium leprae requires disruption of the bacilli.
Leprosy review 2008;79(3):311-4.
2008: Richard W Truman; P Kyle Andrews; Naoko Y Robbins; Linda B Adams; James L Krahenbuhl; Thomas P Gillis
Enumeration of Mycobacterium leprae using real-time PCR.
PLoS neglected tropical diseases 2008;2(11):e328.
2007: Ana Lucia O M Sousa; Mariane M A Stefani; Gisner A S Pereira; Maurício Barcelos Costa; Paula F Rebello; Maria Katia Gomes; Kazue Narahashi; Thomas P Gillis; James L Krahenbuhl; Celina Maria Turchi Martelli
Mycobacterium leprae DNA associated with type 1 reactions in single lesion paucibacillary leprosy treated with single dose rifampin, ofloxacin, and minocycline.
The American journal of tropical medicine and hygiene 2007;77(5):829-33.
2007: Malcolm Duthie; Stephen Reece; Ramanuj Lahiri; Wakako Goto; Vanitha S Raman; Juliette Kaplan; Greg C Ireton; Sylvie Bertholet; Thomas P Gillis; James L Krahenbuhl; Steven G Reed
Antigen-specific cellular and humoral responses are induced by intradermal Mycobacterium leprae infection of the mouse ear.
Infection and immunity 2007;75(11):5290-7.
2007: Deanna A Hagge; Vilma T Marks; Nashone A Ray; Marilyn A Dietrich; Michael T Kearney; David M Scollard; James L Krahenbuhl; Linda B Adams
Emergence of an effective adaptive cell mediated immune response to Mycobacterium leprae is not impaired in reactive oxygen intermediate-deficient mice.
FEMS immunology and medical microbiology 2007;51(1):92-101.
2007: Rose Ann Murray; M Ruby Siddiqui; Megan Mendillo; James L Krahenbuhl; Gilla Kaplan
Mycobacterium leprae inhibits dendritic cell activation and maturation.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(1):338-44.
2006: Ujjini H Manjunatha; Ramanuj Lahiri; Baljit Randhawa; Cynthia S Dowd; James L Krahenbuhl; Clifton E Barry
Mycobacterium leprae is naturally resistant to PA-824.
Antimicrobial agents and chemotherapy 2006;50(10):3350-4.
2006: David M Scollard; Linda B Adams; Thomas P Gillis; James L Krahenbuhl; Richard W Truman; Diana L Williams
The continuing challenges of leprosy.
Clinical microbiology reviews 2006;19(2):338-81.
2006: Luis B Barreiro; Hélène Quach; James L Krahenbuhl; Shagufta Khaliq; Aisha Mohyuddin; S Qasim Mehdi; Brigitte Gicquel; Olivier Neyrolles; Lluis Quintana-Murci
DC-SIGN interacts with Mycobacterium leprae but sequence variation in this lectin is not associated with leprosy in the Pakistani population.
Human immunology 2006;67(1-2):102-7.
2005: Ramanuj Lahiri; Baljit Randhawa; James L Krahenbuhl
Effects of purification and fluorescent staining on viability of Mycobacterium leprae.
International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association 2005;73(3):194-202.
2005: Ramanuj Lahiri; Baljit Randhawa; James L Krahenbuhl
Application of a viability-staining method for Mycobacterium leprae derived from the athymic (nu/nu) mouse foot pad.
Journal of medical microbiology 2005;54(Pt 3):235-42.
2004: Deanna A Hagge; Nashone A Ray; James L Krahenbuhl; Linda B Adams
An in vitro model for the lepromatous leprosy granuloma: fate of Mycobacterium leprae from target macrophages after interaction with normal and activated effector macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(12):7771-9.
2004: Yasuo Fukutomi; Masanori Matsuoka; Fumishige Minagawa; Satoshi Toratani; Gregory McCormick; James L Krahenbuhl
IL-10 treatment of macrophages bolsters intracellular survival of Mycobacterium leprae.
International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association 2004;72(1):16-26.
2003: Mariane M A Stefani; Celina Maria Turchi Martelli; Thomas P Gillis; James L Krahenbuhl
In situ type 1 cytokine gene expression and mechanisms associated with early leprosy progression.
The Journal of infectious diseases 2003;188(7):1024-31.
2002: Linda B Adams; David M Scollard; Nashone A Ray; Andrea M Cooper; Anthony A Frank; Ian M Orme; James L Krahenbuhl
The study of Mycobacterium leprae infection in interferon-gamma gene--disrupted mice as a model to explore the immunopathologic spectrum of leprosy.
The Journal of infectious diseases 2002;185 Suppl 1():S1-8.
2001: Richard W Truman; James L Krahenbuhl
Viable M. leprae as a research reagent.
International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association 2001;69(1):1-12.
2000: James L Krahenbuhl; Linda B Adams
Exploitation of gene knockout mice models to study the pathogenesis of leprosy.
Leprosy review 2000;71 Suppl():S170-5.
2000: Celina Maria Turchi Martelli; Mariane M A Stefani; M K Gomes; P F Rebello; S Peninni; K Narahashi; A L Maroclo; Maurício Barcelos Costa; Simonne A Silva; S C Sacchetim; J A C Nery; Ana M Salles; Thomas P Gillis; James L Krahenbuhl; Ana Lucia S S Andrade
Single lesion paucibacillary leprosy: baseline profile of the Brazilian Multicenter Cohort Study.
International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association 2000;68(3):247-57.
2000: Linda B Adams; Charles K Job; James L Krahenbuhl
Role of inducible nitric oxide synthase in resistance to Mycobacterium leprae in mice.
Infection and immunity 2000;68(9):5462-5.
2000: Linda B Adams; N A Soileau; J R Battista; James L Krahenbuhl
Inhibition of metabolism and growth of Mycobacterium leprae by gamma irradiation.
International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association 2000;68(1):1-10.
1999: Linda B Adams; I Sinha; Scott Franzblau; James L Krahenbuhl; RT Mehta
Effective treatment of acute and chronic murine tuberculosis with liposome-encapsulated clofazimine.
Antimicrobial agents and chemotherapy 1999;43(7):1638-43.
1998: C Nasarre; James L Krahenbuhl; Thomas R Klei
Down regulation of macrophage activation in Brugia pahangi-infected jirds (Meriones unguiculatus).
Infection and immunity 1998;66(3):1063-9.
1997: Linda B Adams; Thomas P Gillis; Daniel H Hwang; James L Krahenbuhl
Effects of essential fatty acid deficiency on prostaglandin E2 production and cell-mediated immunity in a mouse model of leprosy.
Infection and immunity 1997;65(4):1152-7.
1997: Linda B Adams; M C Dinauer; David Morgenstern; James L Krahenbuhl
Comparison of the roles of reactive oxygen and nitrogen intermediates in the host response to Mycobacterium tuberculosis using transgenic mice.
Tubercle and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 1997;78(5-6):237-46.
1996: R S Veazey; David W Horohov; James L Krahenbuhl; H Wayne Taylor; Julian L Oliver; TG Snider
Differences in the kinetics of T cell accumulations in C3H/HeN (Bcg-resistant) and C57BL/6 (Bcg-susceptible) mice infected with Mycobacterium paratuberculosis.
Comparative immunology, microbiology and infectious diseases 1996;19(4):289-304.
1995: R S Veazey; David W Horohov; James L Krahenbuhl; H Wayne Taylor; Julian L Oliver; TG Snider
Comparison of the resistance of C57BL/6 and C3H/He mice to infection with Mycobacterium paratuberculosis.
Veterinary microbiology 1995;47(1-2):79-87.
1995: R S Veazey; H Wayne Taylor; David W Horohov; James L Krahenbuhl; Julian L Oliver; TG Snider
Histopathology of C57BL/6 mice inoculated orally with Mycobacterium paratuberculosis.
Journal of comparative pathology 1995;113(1):75-80.
1995: Linda B Adams; Carol M Mason; Jay K Kolls; David M Scollard; James L Krahenbuhl; S Nelson
Exacerbation of acute and chronic murine tuberculosis by administration of a tumor necrosis factor receptor-expressing adenovirus.
The Journal of infectious diseases 1995;171(2):400-5.
1994: James L Krahenbuhl; Linda B Adams
The role of the macrophage in resistance to the leprosy bacillus.
Immunology series 1994;60():281-302.
1993: James L Krahenbuhl; Y Fukutomi; L Gu
Treatment of acute experimental toxoplasmosis with investigational poloxamers.
Antimicrobial agents and chemotherapy 1993;37(11):2265-9.
1993: Linda B Adams; Y Fukutomi; James L Krahenbuhl
Regulation of murine macrophage effector functions by lipoarabinomannan from mycobacterial strains with different degrees of virulence.
Infection and immunity 1993;61(10):4173-81.
1993: L David Sibley; Linda B Adams; James L Krahenbuhl
Macrophage interactions in toxoplasmosis.
Research in immunology 1993;144(1):38-40.
1991: L David Sibley; Linda B Adams; Y Fukutomi; James L Krahenbuhl
Tumor necrosis factor-alpha triggers antitoxoplasmal activity of IFN-gamma primed macrophages.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(7):2340-5.
1991: N Ramasesh; Linda B Adams; Scott Franzblau; James L Krahenbuhl
Effects of activated macrophages on Mycobacterium leprae.
Infection and immunity 1991;59(9):2864-9.
1991: Linda B Adams; Scott Franzblau; Z Vavrin; J B Hibbs; James L Krahenbuhl
L-arginine-dependent macrophage effector functions inhibit metabolic activity of Mycobacterium leprae.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(5):1642-6.
1990: James L Krahenbuhl; L David Sibley; G T Chae
Gamma interferon in experimental leprosy.
Diagnostic microbiology and infectious disease 1990;13(5):405-9.
1990: Linda B Adams; J B Hibbs; R R Taintor; James L Krahenbuhl
Microbiostatic effect of murine-activated macrophages for Toxoplasma gondii. Role for synthesis of inorganic nitrogen oxides from L-arginine.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(7):2725-9.
1990: L David Sibley; Linda B Adams; James L Krahenbuhl
Inhibition of interferon-gamma-mediated activation in mouse macrophages treated with lipoarabinomannan.
Clinical and experimental immunology 1990;80(1):141-8.
1989: N Ramasesh; James L Krahenbuhl; R C Hastings
In vitro effects of antimicrobial agents on Mycobacterium leprae in mouse peritoneal macrophages.
Antimicrobial agents and chemotherapy 1989;33(5):657-62.
1988: L David Sibley; James L Krahenbuhl
Modification of host cell phagosomes by Toxoplasma gondii involves redistribution of surface proteins and secretion of a 32 kDa protein.
European journal of cell biology 1988;47(1):81-7.
1988: D P Harris; A G Jones; S Wade; James L Krahenbuhl; Thomas P Gillis; J D Watson
Genetic control of murine T cell proliferative responses to Mycobacterium leprae. V. Evidence for cross-reactivity between host antigens and Mycobacterium leprae.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(5):1695-700.
1988: L David Sibley; James L Krahenbuhl
Induction of unresponsiveness to gamma interferon in macrophages infected with Mycobacterium leprae.
Infection and immunity 1988;56(8):1912-9.
1988: R C Hastings; Thomas P Gillis; James L Krahenbuhl; Scott Franzblau
Leprosy.
Clinical microbiology reviews 1988;1(3):330-48.
1988: L David Sibley; S W Hunter; P J Brennan; James L Krahenbuhl
Mycobacterial lipoarabinomannan inhibits gamma interferon-mediated activation of macrophages.
Infection and immunity 1988;56(5):1232-6.
1988: R N Mshana; R C Hastings; James L Krahenbuhl
Infection with live mycobacteria inhibits in vitro detection of Ia antigen on macrophages.
Immunobiology 1988;177(1):40-54.
1988: L David Sibley; James L Krahenbuhl
Defective activation of granuloma macrophages from Mycobacterium leprae-infected nude mice.
Journal of leukocyte biology 1988;43(1):60-6.
1987: N Ramasesh; R C Hastings; James L Krahenbuhl
Metabolism of Mycobacterium leprae in macrophages.
Infection and immunity 1987;55(5):1203-6.
1987: L David Sibley; Scott Franzblau; James L Krahenbuhl
Intracellular fate of Mycobacterium leprae in normal and activated mouse macrophages.
Infection and immunity 1987;55(3):680-5.
1987: L David Sibley; James L Krahenbuhl
Mycobacterium leprae-burdened macrophages are refractory to activation by gamma interferon.
Infection and immunity 1987;55(2):446-50.
1986: L David Sibley; James L Krahenbuhl; G M Adams; E Weidner
Toxoplasma modifies macrophage phagosomes by secretion of a vesicular network rich in surface proteins.
The Journal of cell biology 1986;103(3):867-74.
1985: L David Sibley; James L Krahenbuhl; E Weidner
Lymphokine activation of J774G8 cells and mouse peritoneal macrophages challenged with Toxoplasma gondii.
Infection and immunity 1985;49(3):760-4.
1985: L David Sibley; E Weidner; James L Krahenbuhl
Phagosome acidification blocked by intracellular Toxoplasma gondii.
Nature 1985;315(6018):416-9.

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