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Adrian Krainer

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Physiology

RNA Splicing

Chemicals & Drugs

Anatomy

Concepts & Ideas

Molecular Sequence Data

Genes & Molecular Sequences

Amino Acid Sequence

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Co-Publications
Name
12
Cáceres, Javier
10
Cartegni, Luca
10
Mayeda, A
9
Zhang, Michael
8
Hastings, Michelle
7
Xu, Rui-Ming
7
Roca, Xavier
6
Mayeda, Akila
6
Chew, Shern
5
Sachidanandam, Ravi
5
Spector, David
5
Allemand, eric
4
Screaton, Gavin
3
Robson, Stephen
3
Murray, Michael

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Publications

TOP 3
Okunola Hazeem L; Krainer Adrian R
Cooperative-binding and splicing-repressive properties of hnRNP A1.
Prior Thomas W; Krainer Adrian R; Hua Yimin; Swoboda Kathryn J; Snyder Pamela C; Bridgeman Scott J; Burghes Arthur H M; Kissel John T
A positive modifier of spinal muscular atrophy in the SMN2 gene.
Khoo Bernard; Krainer Adrian R
Splicing therapeutics in SMN2 and APOB.

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All Publications

2009: Okunola Hazeem L; Krainer Adrian R
Cooperative-binding and splicing-repressive properties of hnRNP A1.
Molecular and cellular biology 2009;29(20):5620-31.
2009: Prior Thomas W; Krainer Adrian R; Hua Yimin; Swoboda Kathryn J; Snyder Pamela C; Bridgeman Scott J; Burghes Arthur H M; Kissel John T
A positive modifier of spinal muscular atrophy in the SMN2 gene.
American journal of human genetics 2009;85(3):408-13.
2009: Khoo Bernard; Krainer Adrian R
Splicing therapeutics in SMN2 and APOB.
Current opinion in molecular therapeutics 2009;11(2):108-15.
2009: Martins de Araújo Mafalda; Bonnal Sophie; Hastings Michelle L; Krainer Adrian R; Valcárcel Juan
Differential 3' splice site recognition of SMN1 and SMN2 transcripts by U2AF and U2 snRNP.
RNA (New York, N.Y.) 2009;15(4):515-23.
2009: Roca Xavier; Krainer Adrian R
A splicing component adapted to gene silencing.
Nature biotechnology 2009;27(3):250-1.
2009: Roca Xavier; Krainer Adrian R
Recognition of atypical 5' splice sites by shifted base-pairing to U1 snRNA.
Nature structural & molecular biology 2009;16(2):176-82.
2008: Karni Rotem; Hippo Yoshitaka; Lowe Scott W; Krainer Adrian R
The splicing-factor oncoprotein SF2/ASF activates mTORC1.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(40):15323-7.
2008: Zhang Chaolin; Zhang Zuo; Castle John; Sun Shuying; Johnson Jason; Krainer Adrian R; Zhang Michael Q
Defining the regulatory network of the tissue-specific splicing factors Fox-1 and Fox-2.
Genes & development 2008;22(18):2550-63.
2008: Thorsen Kasper; Sørensen Karina D; Brems-Eskildsen Anne Sofie; Modin Charlotte; Gaustadnes Mette; Hein Anne-Mette K; Kruhøffer Mogens; Laurberg Søren; Borre Michael; Wang Kai; Brunak Søren; Krainer Adrian R; Tørring Niels; Dyrskjøt Lars; Andersen Claus L; Orntoft Torben F
Alternative splicing in colon, bladder, and prostate cancer identified by exon array analysis.
Molecular & cellular proteomics : MCP 2008;7(7):1214-24.
2008: Steitz Joan A; Dreyfuss Gideon; Krainer Adrian R; Lamond Angus I; Matera A Gregory; Padgett Richard A
Where in the cell is the minor spliceosome?
Proceedings of the National Academy of Sciences of the United States of America 2008;105(25):8485-6.
2008: Zhang Chaolin; Li Wen-Hsiung; Krainer Adrian R; Zhang Michael Q
RNA landscape of evolution for optimal exon and intron discrimination.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(15):5797-802.
2008: Hua Yimin; Vickers Timothy A; Okunola Hazeem L; Bennett C Frank; Krainer Adrian R
Antisense masking of an hnRNP A1/A2 intronic splicing silencer corrects SMN2 splicing in transgenic mice.
American journal of human genetics 2008;82(4):834-48.
2008: Majerciak Vladimir; Yamanegi Koji; Allemand Eric; Kruhlak Michael; Krainer Adrian R; Zheng Zhi-Ming
Kaposi's sarcoma-associated herpesvirus ORF57 functions as a viral splicing factor and promotes expression of intron-containing viral lytic genes in spliceosome-mediated RNA splicing.
Journal of virology 2008;82(6):2792-801.
2008: Chen Gengxin; Li Wanhe; Zhang Qing-Shuo; Regulski Michael; Sinha Nishi; Barditch Jody; Tully Tim; Krainer Adrian R; Zhang Michael Q; Dubnau Josh
Identification of synaptic targets of Drosophila pumilio.
PLoS computational biology 2008;4(2):e1000026.
2008: Roca Xavier; Olson Andrew J; Rao Atmakuri R; Enerly Espen; Kristensen Vessela N; Børresen-Dale Anne-Lise; Andresen Brage S; Krainer Adrian R; Sachidanandam Ravi
Features of 5'-splice-site efficiency derived from disease-causing mutations and comparative genomics.
Genome research 2008;18(1):77-87.
2007: Zhang Chaolin; Krainer Adrian R; Zhang Michael Q
Evolutionary impact of limited splicing fidelity in mammalian genes.
Trends in genetics : TIG 2007;23(10):484-8.
2007: Zhang Chaolin; Hastings Michelle L; Krainer Adrian R; Zhang Michael Q
Dual-specificity splice sites function alternatively as 5' and 3' splice sites.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(38):15028-33.
2007: Caceres Javier F; Krainer Adrian R; Kornblihtt Alberto R
The pathology of pre-mRNA splicing: a meeting in the Italian Alps. Workshop on pre-mRNA processing and disease.
EMBO reports 2007;8(8):730-4.
2007: Zhang Zuo; Krainer Adrian R
Splicing remodels messenger ribonucleoprotein architecture via eIF4A3-dependent and -independent recruitment of exon junction complex components.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(28):11574-9.
2007: Allemand Eric; Hastings Michelle L; Murray Michael V; Myers Michael P; Krainer Adrian R
Alternative splicing regulation by interaction of phosphatase PP2Cgamma with nucleic acid-binding protein YB-1.
Nature structural & molecular biology 2007;14(7):630-8.
2007: Das Rita; Yu Jiong; Zhang Zuo; Gygi Melanie P; Krainer Adrian R; Gygi Steven P; Reed Robin
SR proteins function in coupling RNAP II transcription to pre-mRNA splicing.
Molecular cell 2007;26(6):867-81.
2007: Wimmer K; Roca X; Beiglböck H; Callens T; Etzler J; Rao A R; Krainer A R; Fonatsch C; Messiaen L
Extensive in silico analysis of NF1 splicing defects uncovers determinants for splicing outcome upon 5' splice-site disruption.
Human mutation 2007;28(6):599-612.
2007: Hua Yimin; Vickers Timothy A; Baker Brenda F; Bennett C Frank; Krainer Adrian R
Enhancement of SMN2 exon 7 inclusion by antisense oligonucleotides targeting the exon.
PLoS biology 2007;5(4):e73.
2007: Karni Rotem; de Stanchina Elisa; Lowe Scott W; Sinha Rahul; Mu David; Krainer Adrian R
The gene encoding the splicing factor SF2/ASF is a proto-oncogene.
Nature structural & molecular biology 2007;14(3):185-93.
2007: Nielsen Karsten Bork; Sørensen Suzette; Cartegni Luca; Corydon Thomas Juhl; Doktor Thomas Koed; Schroeder Lisbeth Dahl; Reinert Line Sinnathamby; Elpeleg Orly; Krainer Adrian R; Gregersen Niels; Kjems Jørgen; Andresen Brage Storstein
Seemingly neutral polymorphic variants may confer immunity to splicing-inactivating mutations: a synonymous SNP in exon 5 of MCAD protects from deleterious mutations in a flanking exonic splicing enhancer.
American journal of human genetics 2007;80(3):416-32.
2007: Shaw Stephanie D; Chakrabarti Sutapa; Ghosh Gourisankar; Krainer Adrian R
Deletion of the N-terminus of SF2/ASF permits RS-domain-independent pre-mRNA splicing.
PloS one 2007;2(9):e854.
2007: Hastings Michelle L; Allemand Eric; Duelli Dominik M; Myers Michael P; Krainer Adrian R
Control of pre-mRNA splicing by the general splicing factors PUF60 and U2AF65.
PloS one 2007;2(6):e538.
2007: Buratti Emanuele; Chivers Martin; Královicová Jana; Romano Maurizio; Baralle Marco; Krainer Adrian R; Vorechovsky Igor
Aberrant 5' splice sites in human disease genes: mutation pattern, nucleotide structure and comparison of computational tools that predict their utilization.
Nucleic acids research 2007;35(13):4250-63.
2007: Khoo Bernard; Roca Xavier; Chew Shern L; Krainer Adrian R
Antisense oligonucleotide-induced alternative splicing of the APOB mRNA generates a novel isoform of APOB.
BMC molecular biology 2007;8():3.
2006: Kimura Hiroshi; Takizawa Nanako; Allemand Eric; Hori Tetsuya; Iborra Francisco J; Nozaki Naohito; Muraki Michiko; Hagiwara Masatoshi; Krainer Adrian R; Fukagawa Tatsuo; Okawa Katsuya
A novel histone exchange factor, protein phosphatase 2Cgamma, mediates the exchange and dephosphorylation of H2A-H2B.
The Journal of cell biology 2006;175(3):389-400.
2006: Smith Philip J; Zhang Chaolin; Wang Jinhua; Chew Shern L; Zhang Michael Q; Krainer Adrian R
An increased specificity score matrix for the prediction of SF2/ASF-specific exonic splicing enhancers.
Human molecular genetics 2006;15(16):2490-508.
2006: Zhang Qing-Shuo; Manche Lisa; Xu Rui-Ming; Krainer Adrian R
hnRNP A1 associates with telomere ends and stimulates telomerase activity.
RNA (New York, N.Y.) 2006;12(6):1116-28.
2006: Madsen Pia Pinholt; Kibaek Maria; Roca Xavier; Sachidanandam Ravi; Krainer Adrian R; Christensen Ernst; Steiner Robert D; Gibson K Michael; Corydon Thomas J; Knudsen Inga; Wanders Ronald J A; Ruiter Jos P N; Gregersen Niels; Andresen Brage Storstein
Short/branched-chain acyl-CoA dehydrogenase deficiency due to an IVS3+3A>G mutation that causes exon skipping.
Human genetics 2006;118(6):680-90.
2006: Cartegni Luca; Hastings Michelle L; Calarco John A; de Stanchina Elisa; Krainer Adrian R
Determinants of exon 7 splicing in the spinal muscular atrophy genes, SMN1 and SMN2.
American journal of human genetics 2006;78(1):63-77.
2006: Sheth Nihar; Roca Xavier; Hastings Michelle L; Roeder Ted; Krainer Adrian R; Sachidanandam Ravi
Comprehensive splice-site analysis using comparative genomics.
Nucleic acids research 2006;34(14):3955-67.
2005: Tyson-Capper Alison J; Bailey Jarrod; Krainer Adrian R; Robson Stephen C; Europe-Finner G Nicholas
The switch in alternative splicing of cyclic AMP-response element modulator protein CREM{tau}2{alpha} (activator) to CREM{alpha} (repressor) in human myometrial cells is mediated by SRp40.
The Journal of biological chemistry 2005;280(41):34521-9.
2005: Roca Xavier; Sachidanandam Ravi; Krainer Adrian R
Determinants of the inherent strength of human 5' splice sites.
RNA (New York, N.Y.) 2005;11(5):683-98.
2005: Allemand Eric; Guil Sònia; Myers Michael; Moscat Jorge; Cáceres Javier F; Krainer Adrian R
Regulation of heterogenous nuclear ribonucleoprotein A1 transport by phosphorylation in cells stressed by osmotic shock.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(10):3605-10.
2005: Coutinho Gabriela; Xie Jiuyong; Du Liutao; Brusco Alfredo; Krainer Adrian R; Gatti Richard A
Functional significance of a deep intronic mutation in the ATM gene and evidence for an alternative exon 28a.
Human mutation 2005;25(2):118-24.
2005: Hastings Michelle L; Resta Nicoletta; Traum Daniel; Stella Alessandro; Guanti Ginevra; Krainer Adrian R
An LKB1 AT-AC intron mutation causes Peutz-Jeghers syndrome via splicing at noncanonical cryptic splice sites.
Nature structural & molecular biology 2005;12(1):54-9.
2005: Wang Jinhua; Smith Philip J; Krainer Adrian R; Zhang Michael Q
Distribution of SR protein exonic splicing enhancer motifs in human protein-coding genes.
Nucleic acids research 2005;33(16):5053-62.
2004: Zatkova Andrea; Messiaen Ludwine; Vandenbroucke Ina; Wieser Rotraud; Fonatsch Christa; Krainer Adrian R; Wimmer Katharina
Disruption of exonic splicing enhancer elements is the principal cause of exon skipping associated with seven nonsense or missense alleles of NF1.
Human mutation 2004;24(6):491-501.
2004: Zhang Zuo; Krainer Adrian R
Involvement of SR proteins in mRNA surveillance.
Molecular cell 2004;16(4):597-607.
2004: Muraki Michiko; Ohkawara Bisei; Hosoya Takamitsu; Onogi Hiroshi; Koizumi Jun; Koizumi Tomonobu; Sumi Kengo; Yomoda Jun-ichiro; Murray Michael V; Kimura Hiroshi; Furuichi Kiyoshi; Shibuya Hiroshi; Krainer Adrian R; Suzuki Masaaki; Hagiwara Masatoshi
Manipulation of alternative splicing by a newly developed inhibitor of Clks.
The Journal of biological chemistry 2004;279(23):24246-54.
2003: Domsic Jeffrey K; Wang Yibin; Mayeda Akila; Krainer Adrian R; Stoltzfus C Martin
Human immunodeficiency virus type 1 hnRNP A/B-dependent exonic splicing silencer ESSV antagonizes binding of U2AF65 to viral polypyrimidine tracts.
Molecular and cellular biology 2003;23(23):8762-72.
2003: Roca Xavier; Sachidanandam Ravi; Krainer Adrian R
Intrinsic differences between authentic and cryptic 5' splice sites.
Nucleic acids research 2003;31(21):6321-33.
2003: Cartegni Luca; Wang Jinhua; Zhu Zhengwei; Zhang Michael Q; Krainer Adrian R
ESEfinder: A web resource to identify exonic splicing enhancers.
Nucleic acids research 2003;31(13):3568-71.
2003: Cartegni Luca; Krainer Adrian R
Correction of disease-associated exon skipping by synthetic exon-specific activators.
Nature structural biology 2003;10(2):120-5.
2002: Hou Victor C; Lersch Robert; Gee Sherry L; Ponthier Julie L; Lo Annie J; Wu Michael; Turck Chris W; Koury Mark; Krainer Adrian R; Mayeda Akila; Conboy John G
Decrease in hnRNP A/B expression during erythropoiesis mediates a pre-mRNA splicing switch.
The EMBO journal 2002;21(22):6195-204.
2002: Cazalla Demian; Zhu Jun; Manche Lisa; Huber Elisabeth; Krainer Adrian R; Cáceres Javier F
Nuclear export and retention signals in the RS domain of SR proteins.
Molecular and cellular biology 2002;22(19):6871-82.
2002: Fackenthal James D; Cartegni Luca; Krainer Adrian R; Olopade Olufunmilayo I
BRCA2 T2722R is a deleterious allele that causes exon skipping.
American journal of human genetics 2002;71(3):625-31.
2002: Pollard Alison J; Krainer Adrian R; Robson Stephen C; Europe-Finner G Nicholas
Alternative splicing of the adenylyl cyclase stimulatory G-protein G alpha(s) is regulated by SF2/ASF and heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1) and involves the use of an unusual TG 3'-splice Site.
The Journal of biological chemistry 2002;277(18):15241-51.
2002: Cartegni Luca; Chew Shern L; Krainer Adrian R
Listening to silence and understanding nonsense: exonic mutations that affect splicing.
Nature reviews. Genetics 2002;3(4):285-98.
2002: Cartegni Luca; Krainer Adrian R
Disruption of an SF2/ASF-dependent exonic splicing enhancer in SMN2 causes spinal muscular atrophy in the absence of SMN1.
Nature genetics 2002;30(4):377-84.
2002: Vitali Jacqueline; Ding Jianzhong; Jiang Jianzhong; Zhang Ying; Krainer Adrian R; Xu Rui-Ming
Correlated alternative side chain conformations in the RNA-recognition motif of heterogeneous nuclear ribonucleoprotein A1.
Nucleic acids research 2002;30(7):1531-8.
2002: Dance Geoffrey S C; Sowden Mark P; Cartegni Luca; Cooper Ellen; Krainer Adrian R; Smith Harold C
Two proteins essential for apolipoprotein B mRNA editing are expressed from a single gene through alternative splicing.
The Journal of biological chemistry 2002;277(15):12703-9.
2002: Smith Philip J; Spurrell Emma L; Coakley John; Hinds Charles J; Ross Richard J M; Krainer Adrian R; Chew Shern L
An exonic splicing enhancer in human IGF-I pre-mRNA mediates recognition of alternative exon 5 by the serine-arginine protein splicing factor-2/alternative splicing factor.
Endocrinology 2002;143(1):146-54.
2001: Zhu J; Mayeda A; Krainer A R
Exon identity established through differential antagonism between exonic splicing silencer-bound hnRNP A1 and enhancer-bound SR proteins.
Molecular cell 2001;8(6):1351-61.
2001: Bilodeau P S; Domsic J K; Mayeda A; Krainer A R; Stoltzfus C M
RNA splicing at human immunodeficiency virus type 1 3' splice site A2 is regulated by binding of hnRNP A/B proteins to an exonic splicing silencer element.
Journal of virology 2001;75(18):8487-97.
2001: Hastings M L; Krainer A R
Pre-mRNA splicing in the new millennium.
Current opinion in cell biology 2001;13(3):302-9.
2001: Hastings M L; Krainer A R
Functions of SR proteins in the U12-dependent AT-AC pre-mRNA splicing pathway.
RNA (New York, N.Y.) 2001;7(3):471-82.
2001: Liu H X; Cartegni L; Zhang M Q; Krainer A R
A mechanism for exon skipping caused by nonsense or missense mutations in BRCA1 and other genes.
Nature genetics 2001;27(1):55-8.
2000: Zhu J; Krainer A R
Pre-mRNA splicing in the absence of an SR protein RS domain.
Genes & development 2000;14(24):3166-78.
2000: Eperon I C; Makarova O V; Mayeda A; Munroe S H; Cáceres J F; Hayward D G; Krainer A R
Selection of alternative 5' splice sites: role of U1 snRNP and models for the antagonistic effects of SF2/ASF and hnRNP A1.
Molecular and cellular biology 2000;20(22):8303-18.
2000: Pollard A J; Sparey C; Robson S C; Krainer A R; Europe-Finner G N
Spatio-temporal expression of the trans-acting splicing factors SF2/ASF and heterogeneous ribonuclear proteins A1/A1B in the myometrium of the pregnant human uterus: a molecular mechanism for regulating regional protein isoform expression in vivo.
The Journal of clinical endocrinology and metabolism 2000;85(5):1928-36.
2000: van der Houven van Oordt W; Diaz-Meco M T; Lozano J; Krainer A R; Moscat J; Cáceres J F
The MKK(3/6)-p38-signaling cascade alters the subcellular distribution of hnRNP A1 and modulates alternative splicing regulation.
The Journal of cell biology 2000;149(2):307-16.
2000: Liu H X; Chew S L; Cartegni L; Zhang M Q; Krainer A R
Exonic splicing enhancer motif recognized by human SC35 under splicing conditions.
Molecular and cellular biology 2000;20(3):1063-71.
1999: Chew S L; Liu H X; Mayeda A; Krainer A R
Evidence for the function of an exonic splicing enhancer after the first catalytic step of pre-mRNA splicing.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(19):10655-60.
1999: Mayeda A; Badolato J; Kobayashi R; Zhang M Q; Gardiner E M; Krainer A R
Purification and characterization of human RNPS1: a general activator of pre-mRNA splicing.
The EMBO journal 1999;18(16):4560-70.
1999: Ding J; Hayashi M K; Zhang Y; Manche L; Krainer A R; Xu R M
Crystal structure of the two-RRM domain of hnRNP A1 (UP1) complexed with single-stranded telomeric DNA.
Genes & development 1999;13(9):1102-15.
1999: Wu Q; Krainer A R
AT-AC pre-mRNA splicing mechanisms and conservation of minor introns in voltage-gated ion channel genes.
Molecular and cellular biology 1999;19(5):3225-36.
1999: Koizumi J; Okamoto Y; Onogi H; Mayeda A; Krainer A R; Hagiwara M
The subcellular localization of SF2/ASF is regulated by direct interaction with SR protein kinases (SRPKs).
The Journal of biological chemistry 1999;274(16):11125-31.
1999: Jiang J; Zhang Y; Krainer A R; Xu R M
Crystal structure of human p32, a doughnut-shaped acidic mitochondrial matrix protein.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(7):3572-7.
1999: Mayeda A; Screaton G R; Chandler S D; Fu X D; Krainer A R
Substrate specificities of SR proteins in constitutive splicing are determined by their RNA recognition motifs and composite pre-mRNA exonic elements.
Molecular and cellular biology 1999;19(3):1853-63.
1999: Murray M V; Kobayashi R; Krainer A R
The type 2C Ser/Thr phosphatase PP2Cgamma is a pre-mRNA splicing factor.
Genes & development 1999;13(1):87-97.
1999: Mayeda A; Krainer A R
Mammalian in vitro splicing assays.
Methods in molecular biology (Clifton, N.J.) 1999;118():315-21.
1999: Mayeda A; Krainer A R
Preparation of HeLa cell nuclear and cytosolic S100 extracts for in vitro splicing.
Methods in molecular biology (Clifton, N.J.) 1999;118():309-14.
1998: Wu Q; Krainer A R
Purine-rich enhancers function in the AT-AC pre-mRNA splicing pathway and do so independently of intact U1 snRNP.
RNA (New York, N.Y.) 1998;4(12):1664-73.
1998: Misteli T; Cáceres J F; Clement J Q; Krainer A R; Wilkinson M F; Spector D L
Serine phosphorylation of SR proteins is required for their recruitment to sites of transcription in vivo.
The Journal of cell biology 1998;143(2):297-307.
1998: Mayeda A; Munroe S H; Xu R M; Krainer A R
Distinct functions of the closely related tandem RNA-recognition motifs of hnRNP A1.
RNA (New York, N.Y.) 1998;4(9):1111-23.
1998: Liu H X; Zhang M; Krainer A R
Identification of functional exonic splicing enhancer motifs recognized by individual SR proteins.
Genes & development 1998;12(13):1998-2012.
1998: Hanamura A; Cáceres J F; Mayeda A; Franza B R; Krainer A R
Regulated tissue-specific expression of antagonistic pre-mRNA splicing factors.
RNA (New York, N.Y.) 1998;4(4):430-44.
1998: Cáceres J F; Screaton G R; Krainer A R
A specific subset of SR proteins shuttles continuously between the nucleus and the cytoplasm.
Genes & development 1998;12(1):55-66.
1997: Horowitz D S; Kobayashi R; Krainer A R
A new cyclophilin and the human homologues of yeast Prp3 and Prp4 form a complex associated with U4/U6 snRNPs.
RNA (New York, N.Y.) 1997;3(12):1374-87.
1997: Jokan L; Dong A P; Mayeda A; Krainer A R; Xu R M
Crystallization and preliminary X-ray diffraction studies of UP1, the two-RRM domain of hnRNP A1.
Acta crystallographica. Section D, Biological crystallography 1997;53(Pt 5):615-8.
1997: Cáceres J F; Misteli T; Screaton G R; Spector D L; Krainer A R
Role of the modular domains of SR proteins in subnuclear localization and alternative splicing specificity.
The Journal of cell biology 1997;138(2):225-38.
1997: Huang S; Mayeda A; Krainer A R; Spector D L
RCC1 and nuclear organization.
Molecular biology of the cell 1997;8(6):1143-57.
1997: Wu Q; Krainer A R
Splicing of a divergent subclass of AT-AC introns requires the major spliceosomal snRNAs.
RNA (New York, N.Y.) 1997;3(6):586-601.
1997: Xu R M; Jokhan L; Cheng X; Mayeda A; Krainer A R
Crystal structure of human UP1, the domain of hnRNP A1 that contains two RNA-recognition motifs.
Structure (London, England : 1993) 1997;5(4):559-70.
1997: Chandler S D; Mayeda A; Yeakley J M; Krainer A R; Fu X D
RNA splicing specificity determined by the coordinated action of RNA recognition motifs in SR proteins.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(8):3596-601.
1997: Horowitz D S; Krainer A R
A human protein required for the second step of pre-mRNA splicing is functionally related to a yeast splicing factor.
Genes & development 1997;11(1):139-51.
1996: Lopato S; Mayeda A; Krainer A R; Barta A
Pre-mRNA splicing in plants: characterization of Ser/Arg splicing factors.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(7):3074-9.
1995: Screaton G R; Cáceres J F; Mayeda A; Bell M V; Plebanski M; Jackson D G; Bell J I; Krainer A R
Identification and characterization of three members of the human SR family of pre-mRNA splicing factors.
The EMBO journal 1995;14(17):4336-49.
1994: Mayeda A; Munroe S H; Cáceres J F; Krainer A R
Function of conserved domains of hnRNP A1 and other hnRNP A/B proteins.
The EMBO journal 1994;13(22):5483-95.
1994: Cáceres J F; Stamm S; Helfman D M; Krainer A R
Regulation of alternative splicing in vivo by overexpression of antagonistic splicing factors.
Science (New York, N.Y.) 1994;265(5179):1706-9.
1994: Horowitz D S; Krainer A R
Mechanisms for selecting 5' splice sites in mammalian pre-mRNA splicing.
Trends in genetics : TIG 1994;10(3):100-6.
1994: O'Keefe R T; Mayeda A; Sadowski C L; Krainer A R; Spector D L
Disruption of pre-mRNA splicing in vivo results in reorganization of splicing factors.
The Journal of cell biology 1994;124(3):249-60.
1994: Huang M; Rech J E; Northington S J; Flicker P F; Mayeda A; Krainer A R; LeStourgeon W M
The C-protein tetramer binds 230 to 240 nucleotides of pre-mRNA and nucleates the assembly of 40S heterogeneous nuclear ribonucleoprotein particles.
Molecular and cellular biology 1994;14(1):518-33.
1994: Stamm S; Mulligan G J; Krainer A R; Helfman D M
Non-radioactive detection of m3G capped RNAs by immunoblotting.
Nucleic acids research 1994;22(2):252-3.
1993: Birney E; Kumar S; Krainer A R
Analysis of the RNA-recognition motif and RS and RGG domains: conservation in metazoan pre-mRNA splicing factors.
Nucleic acids research 1993;21(25):5803-16.
1993: Sun Q; Mayeda A; Hampson R K; Krainer A R; Rottman F M
General splicing factor SF2/ASF promotes alternative splicing by binding to an exonic splicing enhancer.
Genes & development 1993;7(12B):2598-608.
1993: Cáceres J F; Krainer A R
Functional analysis of pre-mRNA splicing factor SF2/ASF structural domains.
The EMBO journal 1993;12(12):4715-26.
1993: Eperon I C; Ireland D C; Smith R A; Mayeda A; Krainer A R
Pathways for selection of 5' splice sites by U1 snRNPs and SF2/ASF.
The EMBO journal 1993;12(9):3607-17.
1993: Dong B; Horowitz D S; Kobayashi R; Krainer A R
Purification and cDNA cloning of HeLa cell p54nrb, a nuclear protein with two RNA recognition motifs and extensive homology to human splicing factor PSF and Drosophila NONA/BJ6.
Nucleic acids research 1993;21(17):4085-92.
1993: Mayeda A; Helfman D M; Krainer A R
Modulation of exon skipping and inclusion by heterogeneous nuclear ribonucleoprotein A1 and pre-mRNA splicing factor SF2/ASF.
Molecular and cellular biology 1993;13(5):2993-3001.
1993: Birney E; Kumar S; Krainer A R
A putative homology of U2AF65 in S. cerevisiae.
Nucleic acids research 1993;21(5):1333.
1992: Fu X D; Mayeda A; Maniatis T; Krainer A R
General splicing factors SF2 and SC35 have equivalent activities in vitro, and both affect alternative 5' and 3' splice site selection.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(23):11224-8.
1992: Birney E; Kumar S; Krainer A R
A putative homolog of U2AF65 in S. cerevisiae.
Nucleic acids research 1992;20(17):4663.
1992: Mayeda A; Zahler A M; Krainer A R; Roth M B
Two members of a conserved family of nuclear phosphoproteins are involved in pre-mRNA splicing.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(4):1301-4.
1992: Mayeda A; Krainer A R
Regulation of alternative pre-mRNA splicing by hnRNP A1 and splicing factor SF2.
Cell 1992;68(2):365-75.
1991: Krainer A R; Mayeda A; Kozak D; Binns G
Functional expression of cloned human splicing factor SF2: homology to RNA-binding proteins, U1 70K, and Drosophila splicing regulators.
Cell 1991;66(2):383-94.
1991: Mayeda A; Krainer A R
Long-term storage of concentrated tris-borate-EDTA electrophoresis buffers without precipitation.
BioTechniques 1991;10(2):182.
1990: Krainer A R; Conway G C; Kozak D
The essential pre-mRNA splicing factor SF2 influences 5' splice site selection by activating proximal sites.
Cell 1990;62(1):35-42.
1990: Krainer A R; Conway G C; Kozak D
Purification and characterization of pre-mRNA splicing factor SF2 from HeLa cells.
Genes & development 1990;4(7):1158-71.
1989: Conway G C; Krainer A R; Spector D L; Roberts R J
Multiple splicing factors are released from endogenous complexes during in vitro pre-mRNA splicing.
Molecular and cellular biology 1989;9(12):5273-80.
1988: Krainer A R
Pre-mRNA splicing by complementation with purified human U1, U2, U4/U6 and U5 snRNPs.
Nucleic acids research 1988;16(20):9415-29.

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