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Oliver Krämer

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Chemicals & Drugs

Anatomy

Tumor Cell Line

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Laura Conradt; Annika Henrich; Oliver H Krämer; Marina Lesina; Maximilian Reichert; Dieter Saur; Roland M Schmid; Hana Algül; Matthias Wirth; Günter Schneider
Mdm2 inhibitors synergize with topoisomerase II inhibitors to induce p53-independent pancreatic cancer cell death.
Sibyll Pollok; Werner Reichardt; Roland H Stauber; Jana Pieper; Torsten Ginter; Katharina Günzel; Andreas Henke; Oliver H Krämer
Interferon alpha-armed nanoparticles trigger rapid and sustained STAT1-dependent anti-viral cellular responses.
Oliver H Krämer; R H Stauber; Gesine Bug; J Hartkamp; S K Knauer
SIAH proteins: critical roles in leukemogenesis.

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2013: Laura Conradt; Annika Henrich; Oliver H Krämer; Marina Lesina; Maximilian Reichert; Dieter Saur; Roland M Schmid; Hana Algül; Matthias Wirth; Günter Schneider
Mdm2 inhibitors synergize with topoisomerase II inhibitors to induce p53-independent pancreatic cancer cell death.
International journal of cancer. Journal international du cancer 2013;132(10):2248-57.
2013: Sibyll Pollok; Werner Reichardt; Roland H Stauber; Jana Pieper; Torsten Ginter; Katharina Günzel; Andreas Henke; Oliver H Krämer
Interferon alpha-armed nanoparticles trigger rapid and sustained STAT1-dependent anti-viral cellular responses.
Cellular signalling 2013;25(4):989-98.
2013: Oliver H Krämer; R H Stauber; Gesine Bug; J Hartkamp; S K Knauer
SIAH proteins: critical roles in leukemogenesis.
Leukemia 2013;27(4):792-802.
2013: Torsten Ginter; Thorsten Heinzel; Oliver H Krämer
Acetylation of endogenous STAT proteins.
Methods in molecular biology (Clifton, N.J.) 2013;967():167-78.
2012: Martin Wieczorek; Peter Brand; Torsten Ginter; Thorsten Heinzel; Oliver H Krämer
Acetylation modulates the STAT signaling code.
Cytokine & growth factor reviews 2012;23(6):293-305.
2012: Kristin Pietschmann; Harald Polzer; Karsten Spiekermann; Steffi Spielberg; Frank-Dietmar Böhmer; Hella Anna Bolck; Marc Buchwald; Gesine Bug; Thorsten Heinzel; Oliver H Krämer
Breakdown of the FLT3-ITD/STAT5 axis and synergistic apoptosis induction by the histone deacetylase inhibitor panobinostat and FLT3-specific inhibitors.
Molecular cancer therapeutics 2012;11(11):2373-83.
2012: André Brandl; Thorsten Heinzel; Shirley K Knauer; Frauke Melchior; Günter Schneider; Roland H Stauber; Katharina M Uhlig; Tobias Wagner; Oliver H Krämer
Dynamically regulated sumoylation of HDAC2 controls p53 deacetylation and restricts apoptosis following genotoxic stress.
Journal of molecular cell biology 2012;4(5):284-93.
2012: Annette Romanski; Jessica Roos; Martin Ruthardt; Kerstin Schwarz; Hubert Serve; Anja Vogel; Sarah Wietbrauk; Boris Brill; Maren Keller; Oliver H Krämer; Claudia Oancea; Gesine Bug
Deacetylase inhibitors modulate proliferation and self-renewal properties of leukemic stem and progenitor cells.
Cell cycle (Georgetown, Tex.) 2012;11(17):3219-26.
2012: Carolin Bier; Markus Kaiser; Shirley K Knauer; Oliver H Krämer; Lena Kunst; Christian Ottmann; Sabine Scheiding; Désirée Wünsch; Roland H Stauber
Allosteric inhibition of Taspase1's pathobiological activity by enforced dimerization in vivo.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012;26(8):3421-9.
2012: Torsten Ginter; Thorsten Heinzel; Regine Heller; Andreas Henke; Dagmar Hildebrand; Shirley K Knauer; Katharina F Kubatzky; Theresa Liebe; Tobias Münz; Werner Reichardt; Johannes A Schmid; Roland H Stauber; Kalsoom Sughra; Carolin Bier; Oliver H Krämer
Histone deacetylase inhibitors block IFNγ-induced STAT1 phosphorylation.
Cellular signalling 2012;24(7):1453-60.
2012: Wajana L Labisso; Dieter Saur; Roland M Schmid; Angelika Schnieke; Roland H Stauber; Natasa Stojanovic; Matthias Wirth; Oliver H Krämer; Günter Schneider
MYC directs transcription of MCL1 and eIF4E genes to control sensitivity of gastric cancer cells toward HDAC inhibitors.
Cell cycle (Georgetown, Tex.) 2012;11(8):1593-602.
2012: Sascha Dietrich; Peter Dreger; Thomas Giese; Esther Hahn; Michael Hess; Anthony D Ho; Jennifer Hüllein; Oliver H Krämer; Michael Rieger; Claudia Schäfer; Theresa Tretter; Thorsten Zenz; Thomas Luft
Leflunomide induces apoptosis in fludarabine-resistant and clinically refractory CLL cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(2):417-31.
2012: Carolin Bier; Dorothée Goesswein; Rouven Hecht; Shirley K Knauer; Oliver H Krämer; Lena Kunst; Sabine Scheiding; Günter Schneider; Désirée Wünsch; Roland H Stauber
Overexpression of the catalytically impaired Taspase1 T234V or Taspase1 D233A variants does not have a dominant negative effect in T(4;11) leukemia cells.
PloS one 2012;7(5):e34142.
2012: Roland H Stauber; Britta Unruhe; Simona Weisheit; Carolin Bier; Verena Fetz; Torsten Ginter; Negusse Habtemichael; Shirley K Knauer; Claus Liebmann; Frank Nonnenmacher; Sigrid Reichardt; Günter Schneider; Stephanie Spange; Oliver H Krämer
A combination of a ribonucleotide reductase inhibitor and histone deacetylase inhibitors downregulates EGFR and triggers BIM-dependent apoptosis in head and neck cancer.
Oncotarget 2012;3(1):31-43.
2011: Carolin Bier; Dominic Docter; Shirley K Knauer; Oliver H Krämer; Günter Schneider; Roland H Stauber
The importin-alpha/nucleophosmin switch controls taspase1 protease function.
Traffic (Copenhagen, Denmark) 2011;12(6):703-14.
2010: M Buchwald; K Pietschmann; Jörg P Müller; Frank-D Böhmer; Thorsten Heinzel; Oliver H Krämer
Ubiquitin conjugase UBCH8 targets active FMS-like tyrosine kinase 3 for proteasomal degradation.
Leukemia 2010;24(8):1412-21.
2010: S Müller; Oliver H Krämer
Inhibitors of HDACs--effective drugs against cancer?
Current cancer drug targets 2010;10(2):210-28.
2010: Oliver H Krämer; Thorsten Heinzel
Phosphorylation-acetylation switch in the regulation of STAT1 signaling.
Molecular and cellular endocrinology 2010;315(1-2):40-8.
2009: Oliver H Krämer
HDAC2: a critical factor in health and disease.
Trends in pharmacological sciences 2009;30(12):647-55.
2009: Marc Buchwald; Oliver H Krämer; Thorsten Heinzel
HDACi--targets beyond chromatin.
Cancer letters 2009;280(2):160-7.
2009: André Brandl; Thorsten Heinzel; Oliver H Krämer
Histone deacetylases: salesmen and customers in the post-translational modification market.
Biology of the cell / under the auspices of the European Cell Biology Organization 2009;101(4):193-205.
2009: Oliver H Krämer; Shirley K Knauer; Georg Greiner; Enrico Jandt; Sigrid Reichardt; Karl-Heinz Gührs; Roland H Stauber; Frank-D Böhmer; Thorsten Heinzel
A phosphorylation-acetylation switch regulates STAT1 signaling.
Genes & development 2009;23(2):223-35.
2008: Oliver H Krämer; Sylvia Müller; Marc Buchwald; Sigrid Reichardt; Thorsten Heinzel
Mechanism for ubiquitylation of the leukemia fusion proteins AML1-ETO and PML-RARalpha.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(5):1369-79.
2008: Oliver H Krämer; Shirley K Knauer; D Zimmermann; R H Stauber; Thorsten Heinzel
Histone deacetylase inhibitors and hydroxyurea modulate the cell cycle and cooperatively induce apoptosis.
Oncogene 2008;27(6):732-40.
2007: Shirley K Knauer; Oliver H Krämer; Thomas Knösel; Knut Engels; Franz Rödel; Adorján F Kovács; Wolfgang Dietmaier; Ludger Klein-Hitpass; Negusse Habtemichael; Andrea Schweitzer; Jürgen Brieger; Claus Rödel; Wolf Mann; Iver Petersen; Thorsten Heinzel; Roland H Stauber
Nuclear export is essential for the tumor-promoting activity of survivin.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(1):207-16.
2006: Oliver H Krämer; Daniela Baus; Shirley K Knauer; Stefan Stein; Elke Jäger; Roland H Stauber; Manuel Grez; Edith Pfitzner; Thorsten Heinzel
Acetylation of Stat1 modulates NF-kappaB activity.
Genes & development 2006;20(4):473-85.
2003: Oliver H Krämer; Ping Zhu; Heather P Ostendorff; Martin Golebiewski; Jens Tiefenbach; Marvin A Peters; Boris Brill; Bernd Groner; Ingolf Bach; Thorsten Heinzel; Martin Göttlicher
The histone deacetylase inhibitor valproic acid selectively induces proteasomal degradation of HDAC2.
The EMBO journal 2003;22(13):3411-20.
2001: Martin Göttlicher; Saverio Minucci; Ping Zhu; Oliver H Krämer; A Schimpf; Sabrina Giavara; Jonathan P Sleeman; F Lo Coco; Clara Nervi; Pier Giuseppe Pelicci; Thorsten Heinzel
Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells.
The EMBO journal 2001;20(24):6969-78.
2001: Oliver H Krämer; Martin Göttlicher; Thorsten Heinzel
Histone deacetylase as a therapeutic target.
Trends in endocrinology and metabolism: TEM 2001;12(7):294-300.