FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Werner Kramer

Research Profile

Chemicals & Drugs

Anatomy

Living Beings

Physiology

Concepts & Ideas

Co-author Network

Publications

TOP 3
Werner Kramer
Transporters, Trojan horses and therapeutics: suitability of bile acid and peptide transporters for drug delivery.
Michaela Liebig; Matthias Gossel; Jeremy Pratt; Mark Black; Guido Haschke; Ralf Elvert; Hans-Paul Juretschke; Claudia Neumann-Haefelin; Werner Kramer; Andreas W Herling
Profiling of energy metabolism in olanzapine-induced weight gain in rats and its prevention by the CB1-antagonist AVE1625.
Martin Bickel; Harm Brummerhop; Wendelin Frick; Heiner Glombik; Andreas Waldemar Herling; Hubert Otto Heuer; Oliver Plettenburg; Stefan Theis; Ulrich Werner; Werner Kramer
Effects of AVE2268, a substituted glycopyranoside, on urinary glucose excretion and blood glucose in mice and rats.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Werner Kramer (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2011: Werner Kramer
Transporters, Trojan horses and therapeutics: suitability of bile acid and peptide transporters for drug delivery.
Biological chemistry 2011;392(1-2):77-94.
2010: Michaela Liebig; Matthias Gossel; Jeremy Pratt; Mark Black; Guido Haschke; Ralf Elvert; Hans-Paul Juretschke; Claudia Neumann-Haefelin; Werner Kramer; Andreas W Herling
Profiling of energy metabolism in olanzapine-induced weight gain in rats and its prevention by the CB1-antagonist AVE1625.
Obesity (Silver Spring, Md.) 2010;18(10):1952-8.
2008: Martin Bickel; Harm Brummerhop; Wendelin Frick; Heiner Glombik; Andreas Waldemar Herling; Hubert Otto Heuer; Oliver Plettenburg; Stefan Theis; Ulrich Werner; Werner Kramer
Effects of AVE2268, a substituted glycopyranoside, on urinary glucose excretion and blood glucose in mice and rats.
Arzneimittel-Forschung 2008;58(11):574-80.
2008: Christoph M Schummer; Ulrich Werner; Norbert Tennagels; Dieter Schmoll; Guido Haschke; Hans-Paul Juretschke; Mulchand S Patel; Martin Gerl; Werner Kramer; Andreas W Herling
Dysregulated pyruvate dehydrogenase complex in Zucker diabetic fatty rats.
American journal of physiology. Endocrinology and metabolism 2008;294(1):E88-96.
2007: Andreas W Herling; Matthias Gossel; Guido Haschke; Siegfried Stengelin; Johanna Kuhlmann-Gottke; Günter Müller; Dieter Schmoll; Werner Kramer
CB1 receptor antagonist AVE1625 affects primarily metabolic parameters independently of reduced food intake in Wistar rats.
American journal of physiology. Endocrinology and metabolism 2007;293(3):E826-32.
2006: Anja Beha; Hans-Paul Juretschke; Johanna Kuhlmann-Gottke; Claudia Neumann-Haefelin; Ulrich Belz; Martin Gerl; Werner Kramer; Michael Roden; Andreas W Herling
Muscle type-specific fatty acid metabolism in insulin resistance: an integrated in vivo study in Zucker diabetic fatty rats.
American journal of physiology. Endocrinology and metabolism 2006;290(5):E989-97.
2006: Werner Kramer; Heiner Glombik
Bile acid reabsorption inhibitors (BARI): novel hypolipidemic drugs.
Current medicinal chemistry 2006;13(9):997-1016.
2006: Werner Kramer; Daniel Corsiero; Frank Girbig; Gerhard Jähne
Rabbit small intestine does not contain an annexin II/caveolin 1 complex as a target for 2-azetidinone cholesterol absorption inhibitors.
Biochimica et biophysica acta 2006;1758(1):45-54.
2005: Johanna Kuhlmann-Gottke; Claudia Neumann-Haefelin; Ulrich Belz; Werner Kramer; Hans-Paul Juretschke; Andreas W Herling
Correlation between insulin resistance and intramyocellular lipid levels in rats.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2005;53(6):1275-82.
2005: Werner Kramer; Frank Girbig; Daniel Corsiero; Anja Pfenninger; Wendelin Frick; Gerhard Jähne; Matthias Rhein; Wolfgang Wendler; Friedrich Lottspeich; Elisabeth O Hochleitner; Evelyn Orsó; Gerd Schmitz
Aminopeptidase N (CD13) is a molecular target of the cholesterol absorption inhibitor ezetimibe in the enterocyte brush border membrane.
The Journal of biological chemistry 2005;280(2):1306-20.
2004: Corinna Schoelch; Johanna Kuhlmann-Gottke; Matthias Gossel; Guenter Mueller; Claudia Neumann-Haefelin; Ulrich Belz; Juergen Kalisch; Gabriele Biemer-Daub; Werner Kramer; Hans-Paul Juretschke; Andreas W Herling
Characterization of adenosine-A1 receptor-mediated antilipolysis in rats by tissue microdialysis, 1H-spectroscopy, and glucose clamp studies.
Diabetes 2004;53(7):1920-6.
2004: Claudia Neumann-Haefelin; Anja Beha; Johanna Kuhlmann-Gottke; Ulrich Belz; Martin Gerl; Manfred Quint; Gabriele Biemer-Daub; Mark Broenstrup; Marion Stein; Elke Kleinschmidt; Hans-Ludwig Schaefer; Dieter Schmoll; Werner Kramer; Hans-Paul Juretschke; Andreas W Herling
Muscle-type specific intramyocellular and hepatic lipid metabolism during starvation in wistar rats.
Diabetes 2004;53(3):528-34.
2003: Kerstin Lischka; Dieter Starke; Klaus Failing; Andreas Herling; Werner Kramer; Ernst Petzinger
Hepatobiliary elimination of bile acid-modified oligodeoxynucleotides in Wistar and TR- rats: evidence for mrp2 as carrier for oligodeoxynucleotides.
Biochemical pharmacology 2003;66(4):565-77.
2003: Werner Kramer; Frank Girbig; Daniel Corsiero; Katja Burger; Falk Fahrenholz; Christian Jung; Günter Müller
Intestinal cholesterol absorption: identification of different binding proteins for cholesterol and cholesterol absorption inhibitors in the enterocyte brush border membrane.
Biochimica et biophysica acta 2003;1633(1):13-26.
2003: Wendelin Frick; Andrea Bauer-Schäfer; Jochen Bauer; Frank Girbig; Daniel Corsiero; Hubert Heuer; Werner Kramer
Synthesis of a biotin-tagged photoaffinity probe of 2-azetidinone cholesterol absorption inhibitors.
Bioorganic & medicinal chemistry 2003;11(8):1639-42.
2003: Michael Kurz; Volker Brachvogel; Hans Matter; Siegfried Stengelin; Harald Thüring; Werner Kramer
Insights into the bile acid transportation system: the human ileal lipid-binding protein-cholyltaurine complex and its comparison with homologous structures.
Proteins 2003;50(2):312-28.
2003: Johanna Kuhlmann-Gottke; Claudia Neumann-Haefelin; Ulrich Belz; Juergen Kalisch; Hans-Paul Juretschke; Marion Stein; Elke Kleinschmidt; Werner Kramer; Andreas W Herling
Intramyocellular lipid and insulin resistance: a longitudinal in vivo 1H-spectroscopic study in Zucker diabetic fatty rats.
Diabetes 2003;52(1):138-44.
2003: Christian V Hulzebos; Henk Wolters; Torsten Plösch; Werner Kramer; Siegfried Stengelin; Frans Stellaard; Pieter J J Sauer; Henkjan J Verkade; Folkert Kuipers
Cyclosporin a and enterohepatic circulation of bile salts in rats: decreased cholate synthesis but increased intestinal reabsorption.
The Journal of pharmacology and experimental therapeutics 2003;304(1):356-63.
2002: Andreas W Herling; Dietmar Schwab; Hans-Joerg burgerh; Jochen Maas; Roland Hammerl; Dietmar Schmidt; Sabine Strohschein; Horst Hemmerle; Gerrit Schubert; Stefan Petry; Werner Kramer
Prolonged blood glucose reduction in mrp-2 deficient rats (GY/TR(-)) by the glucose-6-phosphate translocase inhibitor S 3025.
Biochimica et biophysica acta 2002;1569(1-3):105-10.
2001: Junichi Shoda; Masahito Kano; Koji Oda; J Kamiya; Yuji Nimura; Hiroshi Suzuki; Yuichi Sugiyama; H Miyazaki; Takeshi Todoroki; Siegfried Stengelin; Werner Kramer; Yasushi Matsuzaki; Naomi Tanaka
The expression levels of plasma membrane transporters in the cholestatic liver of patients undergoing biliary drainage and their association with the impairment of biliary secretory function.
The American journal of gastroenterology 2001;96(12):3368-78.
2001: Werner Kramer; Frank Girbig; Heiner Glombik; Daniel Corsiero; Siegfried Stengelin; C Weyland
Identification of a ligand-binding site in the Na+/bile acid cotransporting protein from rabbit ileum.
The Journal of biological chemistry 2001;276(38):36020-7.
2001: Dieter Starke; K Lischka; P Pagels; E Uhlmann; Werner Kramer; G Wess; Ernst Petzinger
Bile acid-oligodeoxynucleotide conjugates: synthesis and liver excretion in rats.
Bioorganic & medicinal chemistry letters 2001;11(7):945-9.
2001: Werner Kramer; K Sauber; Karl-Heinz Baringhaus; M Kurz; Siegfried Stengelin; G Lange; Daniel Corsiero; Frank Girbig; W König; C Weyland
Identification of the bile acid-binding site of the ileal lipid-binding protein by photoaffinity labeling, matrix-assisted laser desorption ionization-mass spectrometry, and NMR structure.
The Journal of biological chemistry 2001;276(10):7291-301.
2000: Werner Kramer; Heiner Glombik; Stefan Petry; Hubert Heuer; H Schäfer; W Wendler; Daniel Corsiero; Frank Girbig; C Weyland
Identification of binding proteins for cholesterol absorption inhibitors as components of the intestinal cholesterol transporter.
FEBS letters 2000;487(2):293-7.
2000: Peter Sauer; Adolf Stiehl; BA Fitscher; Hans-Dieter Riedel; Christine Benz; Petra Klöters-Plachky; Siegfried Stengelin; Wolfgang Stremmel; Werner Kramer
Downregulation of ileal bile acid absorption in bile-duct-ligated rats.
Journal of hepatology 2000;33(1):2-8.
2000: Guorong Xu; Benjamin L Shneider; Sarah Shefer; Lien B Nguyen; Ashok K Batta; Stephen G Tint; M Arrese; S Thevananther; L Ma; Siegfried Stengelin; Werner Kramer; D Greenblatt; M Pcolinsky; Gerald Salen
Ileal bile acid transport regulates bile acid pool, synthesis, and plasma cholesterol levels differently in cholesterol-fed rats and rabbits.
Journal of lipid research 2000;41(2):298-304.
1999: Andreas W Herling; H Burger; Gerrit Schubert; Horst Hemmerle; H Schaefer; Werner Kramer
Alterations of carbohydrate and lipid intermediary metabolism during inhibition of glucose-6-phosphatase in rats.
European journal of pharmacology 1999;386(1):75-82.
1999: Karl-Heinz Baringhaus; Hans Matter; Siegfried Stengelin; Werner Kramer
Substrate specificity of the ileal and the hepatic Na(+)/bile acid cotransporters of the rabbit. II. A reliable 3D QSAR pharmacophore model for the ileal Na(+)/bile acid cotransporter.
Journal of lipid research 1999;40(12):2158-68.
1999: Hans-Joerg burgerh; Gerrit Schubert; Horst Hemmerle; Werner Kramer; Andreas W Herling
Pharmacological interference with hepatic glucose production.
Annals of the New York Academy of Sciences 1999;892():312-4.
1999: Ernst Petzinger; A Wickboldt; P Pagels; Dieter Starke; Werner Kramer
Hepatobiliary transport of bile acid amino acid, bile acid peptide, and bile acid oligonucleotide conjugates in rats.
Hepatology (Baltimore, Md.) 1999;30(5):1257-68.
1999: Werner Kramer; Siegfried Stengelin; Karl-Heinz Baringhaus; A Enhsen; Hubert Heuer; W Becker; Daniel Corsiero; Frank Girbig; R Noll; C Weyland
Substrate specificity of the ileal and the hepatic Na(+)/bile acid cotransporters of the rabbit. I. Transport studies with membrane vesicles and cell lines expressing the cloned transporters.
Journal of lipid research 1999;40(9):1604-17.
1999: L Meerman; NR Koopen; Vincent Bloks; Harry van Goor; Rick Havinga; B G Wolthers; Werner Kramer; Siegfried Stengelin; Michael Müller; Folkert Kuipers; Peter L M Jansen
Biliary fibrosis associated with altered bile composition in a mouse model of erythropoietic protoporphyria.
Gastroenterology 1999;117(3):696-705.
1999: Werner Kramer; Hans-Joerg burgerh; WJ Arion; Daniel Corsiero; Frank Girbig; C Weyland; Horst Hemmerle; Stefan Petry; P Habermann; Andreas W Herling
Identification of protein components of the microsomal glucose 6-phosphate transporter by photoaffinity labelling.
The Biochemical journal 1999;339 ( Pt 3)():629-38.
1999: Christoph Elsing; BA Fitscher; C Böker; Werner Kramer; Siegfried Stengelin; Wolfgang Stremmel
Expression of a bile acid transporter in biliary epithelial cells from normal and cholestatic rat livers.
European journal of medical research 1999;4(4):165-8.
1998: Uma Sundaram; Sheik Wisel; Siegfried Stengelin; Werner Kramer; V Rajendran
Mechanism of inhibition of Na+-bile acid cotransport during chronic ileal inflammation in rabbits.
The American journal of physiology 1998;275(6 Pt 1):G1259-65.
1998: Werner Kramer; Frank Girbig; U Bewersdorf; S Kohlrautz; C Weyland
Structural studies of the H+/oligopeptide transport system from rabbit small intestine.
Biochimica et biophysica acta 1998;1373(1):179-94.
1998: Werner Kramer; Daniel Corsiero; M Friedrich; Frank Girbig; Siegfried Stengelin; C Weyland
Intestinal absorption of bile acids: paradoxical behaviour of the 14 kDa ileal lipid-binding protein in differential photoaffinity labelling.
The Biochemical journal 1998;333 ( Pt 2)():335-41.
1997: Werner Kramer; G Wess; U Bewersdorf; Daniel Corsiero; Frank Girbig; C Weyland; Siegfried Stengelin; A Enhsen; K Bock; H Kleine; M A Le Dreau; H L Schäfer
Topological photoaffinity labeling of the rabbit ileal Na+/bile-salt-cotransport system.
European journal of biochemistry / FEBS 1997;249(2):456-64.
1997: Gerd A Kullak-Ublick; J Glasa; C Böker; Melanie Oswald; U Grützner; B Hagenbuch; B Stieger; Peter J Meier Abt; Ulrich Beuers; Werner Kramer; G Wess; Gustav Paumgartner
Chlorambucil-taurocholate is transported by bile acid carriers expressed in human hepatocellular carcinomas.
Gastroenterology 1997;113(4):1295-305.
1996: Werner Kramer; G Wess
Bile acid transport systems as pharmaceutical targets.
European journal of clinical investigation 1996;26(9):715-32.
1996: Siegfried Stengelin; S Apel; W Becker; M Maier; J Rosenberger; U Bewersdorf; Frank Girbig; C Weyland; G Wess; Werner Kramer
The rabbit ileal lipid-binding protein. Gene cloning and functional expression of the recombinant protein.
European journal of biochemistry / FEBS 1996;239(3):887-96.
1995: Werner Kramer
Identification of the bile acid binding proteins in human serum by photoaffinity labeling.
Biochimica et biophysica acta 1995;1257(3):230-8.
1995: Werner Kramer; G Müller; Frank Girbig; U Gutjahr; S Kowalewski; D Hartz; H D Summ
The molecular interaction of sulfonylureas with beta-cell ATP-sensitive K(+)-channels.
Diabetes research and clinical practice 1995;28 Suppl():S67-80.
1995: Werner Kramer; Frank Girbig; U Gutjahr; S Kowalewski
Radiation-inactivation analysis of the Na+/bile acid co-transport system from rabbit ileum.
The Biochemical journal 1995;306 ( Pt 1)():241-6.
1994: Werner Kramer; G Wess; A Enhsen; K Bock; E Falk; A Hoffmann; G Neckermann; D Gantz; S Schulz; L Nickau
Bile acid derived HMG-CoA reductase inhibitors.
Biochimica et biophysica acta 1994;1227(3):137-54.
1994: G Wess; Werner Kramer; X B Han; K Bock; A Enhsen; H Glombik; Karl-Heinz Baringhaus; G Böger; M Urmann; A Hoffmann
Synthesis and biological activity of bile acid-derived HMG-CoA reductase inhibitors. The role of 21-methyl in recognition of HMG-CoA reductase and the ileal bile acid transport system.
Journal of medicinal chemistry 1994;37(20):3240-6.
1994: Werner Kramer; G Müller; Frank Girbig; U Gutjahr; S Kowalewski; D Hartz; H D Summ
Differential interaction of glimepiride and glibenclamide with the beta-cell sulfonylurea receptor. II. Photoaffinity labeling of a 65 kDa protein by [3H]glimepiride.
Biochimica et biophysica acta 1994;1191(2):278-90.
1994: G Müller; D Hartz; J Pünter; R Okonomopulos; Werner Kramer
Differential interaction of glimepiride and glibenclamide with the beta-cell sulfonylurea receptor. I. Binding characteristics.
Biochimica et biophysica acta 1994;1191(2):267-77.
1994: Werner Kramer; G Wess; G Neckermann; G Schubert; J Fink; Frank Girbig; U Gutjahr; S Kowalewski; Karl-Heinz Baringhaus; G Böger
Intestinal absorption of peptides by coupling to bile acids.
The Journal of biological chemistry 1994;269(14):10621-7.
1994: G Wess; Werner Kramer; A Enhsen; H Glombik; Karl-Heinz Baringhaus; G Böger; M Urmann; K Bock; H Kleine; G Neckermann
Specific inhibitors of ileal bile acid transport.
Journal of medicinal chemistry 1994;37(7):873-5.
1993: Werner Kramer; Frank Girbig; U Gutjahr; S Kowalewski; K Jouvenal; G Müller; D Tripier; G Wess
Intestinal bile acid absorption. Na(+)-dependent bile acid transport activity in rabbit small intestine correlates with the coexpression of an integral 93-kDa and a peripheral 14-kDa bile acid-binding membrane protein along the duodenum-ileum axis.
The Journal of biological chemistry 1993;268(24):18035-46.
1993: Werner Kramer; U Gutjahr; S Kowalewski; Frank Girbig
Interaction of the orally active dianionic cephalosporin cefixime with the uptake system for oligopeptides and alpha-amino-beta-lactam antibiotics in rabbit small intestine.
Biochemical pharmacology 1993;46(3):542-6.
1992: Werner Kramer; S B Nicol; Frank Girbig; U Gutjahr; S Kowalewski; H Fasold
Characterization and chemical modification of the Na(+)-dependent bile-acid transport system in brush-border membrane vesicles from rabbit ileum.
Biochimica et biophysica acta 1992;1111(1):93-102.
1992: Werner Kramer; G Wess; G Schubert; M Bickel; Frank Girbig; U Gutjahr; S Kowalewski; Karl-Heinz Baringhaus; A Enhsen; H Glombik
Liver-specific drug targeting by coupling to bile acids.
The Journal of biological chemistry 1992;267(26):18598-604.
1992: Werner Kramer; Frank Girbig; U Gutjahr; S Kowalewski; F Adam; W Schiebler
Intestinal absorption of beta-lactam antibiotics and oligopeptides. Functional and stereospecific reconstitution of the oligopeptide transport system from rabbit small intestine.
European journal of biochemistry / FEBS 1992;204(2):923-30.
1992: H W Kleemann; Holger Heitsch; R Henning; Werner Kramer; W Kocher; U Lerch; Wolfgang Linz; W U Nickel; D Ruppert; H Urbach
Renin inhibitory pentols showing improved enteral bioavailability.
Journal of medicinal chemistry 1992;35(3):559-67.
1990: Werner Kramer; U Gutjahr; Frank Girbig; I Leipe
Intestinal absorption of dipeptides and beta-lactam antibiotics. II. Purification of the binding protein for dipeptides and beta-lactam antibiotics from rabbit small intestinal brush border membranes.
Biochimica et biophysica acta 1990;1030(1):50-9.
1990: Werner Kramer; C Dechent; Frank Girbig; U Gutjahr; H Neubauer
Intestinal uptake of dipeptides and beta-lactam antibiotics. I. The intestinal uptake system for dipeptides and beta-lactam antibiotics is not part of a brush border membrane peptidase.
Biochimica et biophysica acta 1990;1030(1):41-9.
1990: Werner Kramer; Frank Girbig; U Gutjahr; I Leipe
Application of high-performance liquid chromatography to the purification of the putative intestinal peptide transporter.
Journal of chromatography 1990;521(2):199-210.
1990: Werner Kramer; W Dürckheimer; Frank Girbig; U Gutjahr; I Leipe; R Oekonomopulos
Influence of amino acid side-chain modification on the uptake system for beta-lactam antibiotics and dipeptides from rabbit small intestine.
Biochimica et biophysica acta 1990;1028(2):174-82.
1990: Werner Kramer; Frank Girbig; U Gutjahr; H W Kleemann; I Leipe; H Urbach; A Wagner
Interaction of renin inhibitors with the intestinal uptake system for oligopeptides and beta-lactam antibiotics.
Biochimica et biophysica acta 1990;1027(1):25-30.
1988: C Cojocel; Werner Kramer; D Mayer
Depletion of cytochrome P-450 and alterations in activities of drug metabolizing enzymes induced by cephaloridine in the rat kidney cortex.
Biochemical pharmacology 1988;37(19):3781-5.
1988: Werner Kramer; Frank Girbig; E Petzoldt; I Leipe
Inactivation of the intestinal uptake system for beta-lactam antibiotics by diethylpyrocarbonate.
Biochimica et biophysica acta 1988;943(2):288-96.
1988: Werner Kramer; Frank Girbig; I Leipe; E Petzoldt
Direct photoaffinity labelling of binding proteins for beta-lactam antibiotics in rabbit intestinal brush border membranes with [3H]benzylpenicillin.
Biochemical pharmacology 1988;37(12):2427-35.
1988: Werner Kramer; I Leipe; E Petzoldt; Frank Girbig
Characterization of the transport system for beta-lactam antibiotics and dipeptides in rat renal brush-border membrane vesicles by photoaffinity labeling.
Biochimica et biophysica acta 1988;939(1):167-72.
1988: Werner Kramer; R Oekonomopulos; J Pünter; H D Summ
Direct photoaffinity labeling of the putative sulfonylurea receptor in rat beta-cell tumor membranes by [3H]glibenclamide.
FEBS letters 1988;229(2):355-9.
1987: Werner Kramer
Identification of identical binding polypeptides for cephalosporins and dipeptides in intestinal brush-border membrane vesicles by photoaffinity labeling.
Biochimica et biophysica acta 1987;905(1):65-74.