Peter Krammer

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Heid Julia B; Schmidt Angelika; Oberle Nina; Goerdt Sergij; Krammer Peter H; Suri-Payer Elisabeth; Klemke Claus-Detlev
FOXP3+CD25- tumor cells with regulatory function in Sézary syndrome.
Lavrik Inna N; Eils Roland; Fricker Nicolai; Pforr Carina; Krammer Peter H
Understanding apoptosis by systems biology approaches.
Zhu J Y; Giaisi M; Köhler R; Müller W W; Mühleisen A; Proksch P; Krammer P H; Li-Weber M
Rocaglamide sensitizes leukemic T cells to activation-induced cell death by differential regulation of CD95L and c-FLIP expression.

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All Publications

2009: Heid Julia B; Schmidt Angelika; Oberle Nina; Goerdt Sergij; Krammer Peter H; Suri-Payer Elisabeth; Klemke Claus-Detlev
FOXP3+CD25- tumor cells with regulatory function in Sézary syndrome.
The Journal of investigative dermatology 2009;129(12):2875-85.
2009: Lavrik Inna N; Eils Roland; Fricker Nicolai; Pforr Carina; Krammer Peter H
Understanding apoptosis by systems biology approaches.
Molecular bioSystems 2009;5(10):1105-11.
2009: Zhu J Y; Giaisi M; Köhler R; Müller W W; Mühleisen A; Proksch P; Krammer P H; Li-Weber M
Rocaglamide sensitizes leukemic T cells to activation-induced cell death by differential regulation of CD95L and c-FLIP expression.
Cell death and differentiation 2009;16(9):1289-99.
2009: Brenner Dirk; Brechmann Markus; Röhling Simone; Tapernoux Myriam; Mock Thomas; Winter Dominic; Lehmann Wolf D; Kiefer Friedemann; Thome Margot; Krammer Peter H; Arnold Rüdiger
Phosphorylation of CARMA1 by HPK1 is critical for NF-kappaB activation in T cells.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(34):14508-13.
2009: Hoffmann Julia C; Pappa Alexander; Krammer Peter H; Lavrik Inna N
A new C-terminal cleavage product of procaspase-8, p30, defines an alternative pathway of procaspase-8 activation.
Molecular and cellular biology 2009;29(16):4431-40.
2009: Klemke Claus-Detlev; Brenner Dirk; Weiss Eva-Maria; Schmidt Marc; Leverkus Martin; Gülow Karsten; Krammer Peter H
Lack of T-cell receptor-induced signaling is crucial for CD95 ligand up-regulation and protects cutaneous T-cell lymphoma cells from activation-induced cell death.
Cancer research 2009;69(10):4175-83.
2009: Kiessling Michael K; Klemke Claus D; Kaminski Marcin M; Galani Ioanna E; Krammer Peter H; Gülow Karsten
Inhibition of constitutively activated nuclear factor-kappaB induces reactive oxygen species- and iron-dependent cell death in cutaneous T-cell lymphoma.
Cancer research 2009;69(6):2365-74.
2009: Vick Binje; Weber Achim; Urbanik Toni; Maass Thorsten; Teufel Andreas; Krammer Peter H; Opferman Joseph T; Schuchmann Marcus; Galle Peter R; Schulze-Bergkamen Henning
Knockout of myeloid cell leukemia-1 induces liver damage and increases apoptosis susceptibility of murine hepatocytes.
Hepatology (Baltimore, Md.) 2009;49(2):627-36.
2008: Lavrik Inna N; Mock Thomas; Golks Alexander; Hoffmann Julia C; Baumann Simone; Krammer Peter H
CD95 stimulation results in the formation of a novel death effector domain protein-containing complex.
The Journal of biological chemistry 2008;283(39):26401-8.
2008: Hebenstreit Daniel; Giaisi Marco; Treiber Monika K; Zhang Xiao-Bin; Mi Huai-Feng; Horejs-Hoeck Jutta; Andersen Kristian G; Krammer Peter H; Duschl Albert; Li-Weber Min
LEF-1 negatively controls interleukin-4 expression through a proximal promoter regulatory element.
The Journal of biological chemistry 2008;283(33):22490-7.
2008: Herzer Kerstin; Grosse-Wilde Anne; Krammer Peter H; Galle Peter R; Kanzler Stephan
Transforming growth factor-beta-mediated tumor necrosis factor-related apoptosis-inducing ligand expression and apoptosis in hepatoma cells requires functional cooperation between Smad proteins and activator protein-1.
Molecular cancer research : MCR 2008;6(7):1169-77.
2008: Brenner Dirk; Krammer Peter H; Arnold Rüdiger
Concepts of activated T cell death.
Critical reviews in oncology/hematology 2008;66(1):52-64.
2008: Hofer Stefan; Eisenbach Christoph; Lukic Ivan K; Schneider Lutz; Bode Konrad; Brueckmann Martina; Mautner Sven; Wente Moritz N; Encke Jens; Werner Jens; Dalpke Alexander H; Stremmel Wolfgang; Nawroth Peter P; Martin Eike; Krammer Peter H; Bierhaus Angelika; Weigand Markus A
Pharmacologic cholinesterase inhibition improves survival in experimental sepsis.
Critical care medicine 2008;36(2):404-8.
2008: Baumann Sven; Fas Stefanie C; Giaisi Marco; Müller Wolfgang W; Merling Anette; Gülow Karsten; Edler Lutz; Krammer Peter H; Li-Weber Min
Wogonin preferentially kills malignant lymphocytes and suppresses T-cell tumor growth by inducing PLCgamma1- and Ca2+-dependent apoptosis.
Blood 2008;111(4):2354-63.
2007: Brenner Dirk; Golks Alexander; Becker Mareike; Müller Wolfgang; Frey Christian R; Novak Rostislav; Melamed Doron; Kiefer Friedemann; Krammer Peter H; Arnold Rüdiger
Caspase-cleaved HPK1 induces CD95L-independent activation-induced cell death in T and B lymphocytes.
Blood 2007;110(12):3968-77.
2007: Zhu Jia Y; Lavrik Inna N; Mahlknecht Ulrich; Giaisi Marco; Proksch Peter; Krammer Peter H; Li-Weber Min
The traditional Chinese herbal compound rocaglamide preferentially induces apoptosis in leukemia cells by modulation of mitogen-activated protein kinase activities.
International journal of cancer. Journal international du cancer 2007;121(8):1839-46.
2007: Oberle Nina; Eberhardt Nadine; Falk Christine S; Krammer Peter H; Suri-Payer Elisabeth
Rapid suppression of cytokine transcription in human CD4+CD25 T cells by CD4+Foxp3+ regulatory T cells: independence of IL-2 consumption, TGF-beta, and various inhibitors of TCR signaling.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(6):3578-87.
2007: Haas Jürgen; Fritzsching Benedikt; Trübswetter Petra; Korporal Mirjam; Milkova Linda; Fritz Brigitte; Vobis Diana; Krammer Peter H; Suri-Payer Elisabeth; Wildemann Brigitte
Prevalence of newly generated naive regulatory T cells (Treg) is critical for Treg suppressive function and determines Treg dysfunction in multiple sclerosis.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(2):1322-30.
2007: Krammer Peter H; Arnold Rüdiger; Lavrik Inna N
Life and death in peripheral T cells.
Nature reviews. Immunology 2007;7(7):532-42.
2007: Franz B; Fritzsching B; Riehl A; Oberle N; Klemke C-D; Sykora J; Quick S; Stumpf C; Hartmann M; Enk A; Ruzicka T; Krammer P H; Suri-Payer E; Kuhn A
Low number of regulatory T cells in skin lesions of patients with cutaneous lupus erythematosus.
Arthritis and rheumatism 2007;56(6):1910-20.
2007: Lavrik Inna N; Golks Alexander; Riess Dagmar; Bentele Martin; Eils Roland; Krammer Peter H
Analysis of CD95 threshold signaling: triggering of CD95 (FAS/APO-1) at low concentrations primarily results in survival signaling.
The Journal of biological chemistry 2007;282(18):13664-71.
2007: Kaminski Marcin; Kiessling Michael; Süss Dorothee; Krammer Peter H; Gülow Karsten
Novel role for mitochondria: protein kinase Ctheta-dependent oxidative signaling organelles in activation-induced T-cell death.
Molecular and cellular biology 2007;27(10):3625-39.
2007: Arnold R; Frey C R; Müller W; Brenner D; Krammer P H; Kiefer F
Sustained JNK signaling by proteolytically processed HPK1 mediates IL-3 independent survival during monocytic differentiation.
Cell death and differentiation 2007;14(3):568-75.
2007: Zhang Chengwen; Wenger Till; Mattern Jürgen; Ilea Septimia; Frey Christian; Gutwein Paul; Altevogt Peter; Bodenmüller Wolfram; Gassler Nikolaus; Schnabel Philipp A; Dienemann Hendrik; Marmé Alexander; Hohenfellner Markus; Haferkamp Axel; Pfitzenmaier Jesco; Gröne Hermann-Josef; Kolb Armin; Büchler Peter; Büchler Markus; Friess Helmut; Rittgen Werner; Edler Lutz; Debatin Klaus-Michael; Krammer Peter H; Rutz Hans P; Herr Ingrid
Clinical and mechanistic aspects of glucocorticoid-induced chemotherapy resistance in the majority of solid tumors.
Cancer biology & therapy 2007;6(2):278-87.
2007: Efferth Thomas; Giaisi Marco; Merling Annette; Krammer Peter H; Li-Weber Min
Artesunate induces ROS-mediated apoptosis in doxorubicin-resistant T leukemia cells.
PloS one 2007;2(1):e693.
2007: Krammer Peter H; Kaminski Marcin; Kiessling Michael; Gülow Karsten
No life without death.
Advances in cancer research 2007;97():111-38.
2006: Müller Martina; Schleithoff Elisa Schulze; Stremmel Wolfgang; Melino Gerry; Krammer Peter H; Schilling Tobias
One, two, three--p53, p63, p73 and chemosensitivity.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2006;9(6):288-306.
2006: Fritzsching Benedikt; Korporal Mirjam; Haas Jürgen; Krammer Peter H; Suri-Payer Elisabeth; Wildemann Brigitte
Similar sensitivity of regulatory T cells towards CD95L-mediated apoptosis in patients with multiple sclerosis and healthy individuals.
Journal of the neurological sciences 2006;251(1-2):91-7.
2006: Fas Stefanie C; Baumann Sven; Zhu Jia Yun; Giaisi Marco; Treiber Monika K; Mahlknecht Ulrich; Krammer Peter H; Li-Weber Min
Wogonin sensitizes resistant malignant cells to TNFalpha- and TRAIL-induced apoptosis.
Blood 2006;108(12):3700-6.
2006: Fas Stefanie C; Baumann Sven; Krueger Andreas; Frey Christian R; Schulze-Bergkamen Henning; Brenner Dirk; Stumpf Christine; Kappes Kathrin; Krammer Peter H
In vitro generated human memory-like T cells are CD95 type II cells and resistant towards CD95-mediated apoptosis.
European journal of immunology 2006;36(11):2894-903.
2006: Fritzsching Benedikt; Oberle Nina; Pauly Eva; Geffers Robert; Buer Jan; Poschl Johannes; Krammer Peter; Linderkamp Otwin; Suri-Payer Elisabeth
Naive regulatory T cells: a novel subpopulation defined by resistance toward CD95L-mediated cell death.
Blood 2006;108(10):3371-8.
2006: Kuhn A; Krammer P H; Kolb-Bachofen V
Pathophysiology of cutaneous lupus erythematosus--novel aspects.
Rheumatology (Oxford, England) 2006;45 Suppl 3():iii14-6.
2006: Wenger T; Mattern J; Penzel R; Gassler N; Haas T L; Sprick M R; Walczak H; Krammer P H; Debatin K-M; Herr I
Specific resistance upon lentiviral TRAIL transfer by intracellular retention of TRAIL receptors.
Cell death and differentiation 2006;13(10):1740-51.
2006: Kern Michael A; Haugg Anke M; Koch Andreas F; Schilling Tobias; Breuhahn Kai; Walczak Henning; Fleischer Binje; Trautwein Christian; Michalski Christoph; Schulze-Bergkamen Henning; Friess Helmut; Stremmel Wolfgang; Krammer Peter H; Schirmacher Peter; Müller Martina
Cyclooxygenase-2 inhibition induces apoptosis signaling via death receptors and mitochondria in hepatocellular carcinoma.
Cancer research 2006;66(14):7059-66.
2006: Lavrik Inna N; Golks Alexander; Baumann Simone; Krammer Peter H
Caspase-2 is activated at the CD95 death-inducing signaling complex in the course of CD95-induced apoptosis.
Blood 2006;108(2):559-65.
2006: Arnold Rüdiger; Brenner Dirk; Becker Mareike; Frey Christian R; Krammer Peter H
How T lymphocytes switch between life and death.
European journal of immunology 2006;36(7):1654-8.
2006: Klemke C-D; Fritzsching B; Franz B; Kleinmann E V; Oberle N; Poenitz N; Sykora J; Banham A H; Roncador G; Kuhn A; Goerdt S; Krammer P H; Suri-Payer E
Paucity of FOXP3+ cells in skin and peripheral blood distinguishes Sézary syndrome from other cutaneous T-cell lymphomas.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2006;20(6):1123-9.
2006: Golks Alexander; Brenner Dirk; Krammer Peter H; Lavrik Inna N
The c-FLIP-NH2 terminus (p22-FLIP) induces NF-kappaB activation.
The Journal of experimental medicine 2006;203(5):1295-305.
2006: Stieltjes Bram; Klussmann Stefan; Bock Michael; Umathum Reiner; Mangalathu Jain; Letellier Elisabeth; Rittgen Werner; Edler Lutz; Krammer Peter H; Kauczor Hans-Ulrich; Martin-Villalba Ana; Essig Marco
Manganese-enhanced magnetic resonance imaging for in vivo assessment of damage and functional improvement following spinal cord injury in mice.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2006;55(5):1124-31.
2006: Krueger Andreas; Fas Stefanie C; Giaisi Marco; Bleumink Marc; Merling Anette; Stumpf Christine; Baumann Sven; Holtkotte Denise; Bosch Valerie; Krammer Peter H; Li-Weber Min
HTLV-1 Tax protects against CD95-mediated apoptosis by induction of the cellular FLICE-inhibitory protein (c-FLIP).
Blood 2006;107(10):3933-9.
2006: Kuhn Annegret; Herrmann Martin; Kleber Susanne; Beckmann-Welle Maria; Fehsel Karin; Martin-Villalba Ana; Lehmann Percy; Ruzicka Thomas; Krammer Peter H; Kolb-Bachofen Victoria
Accumulation of apoptotic cells in the epidermis of patients with cutaneous lupus erythematosus after ultraviolet irradiation.
Arthritis and rheumatism 2006;54(3):939-50.
2006: Golks A; Brenner D; Schmitz I; Watzl C; Krueger A; Krammer P H; Lavrik I N
The role of CAP3 in CD95 signaling: new insights into the mechanism of procaspase-8 activation.
Cell death and differentiation 2006;13(3):489-98.
2006: Fleischer Binje; Schulze-Bergkamen Henning; Schuchmann Marcus; Weber Achim; Biesterfeld Stefan; Müller Martina; Krammer Peter H; Galle Peter R
Mcl-1 is an anti-apoptotic factor for human hepatocellular carcinoma.
International journal of oncology 2006;28(1):25-32.
2006: Zuliani C; Kleber S; Klussmann S; Wenger T; Kenzelmann M; Schreglmann N; Martinez A; del Rio J A; Soriano E; Vodrazka P; Kuner R; Groene H-J; Herr I; Krammer P H; Martin-Villalba A
Control of neuronal branching by the death receptor CD95 (Fas/Apo-1).
Cell death and differentiation 2006;13(1):31-40.
2006: Schulze-Bergkamen Henning; Fleischer Binje; Schuchmann Marcus; Weber Achim; Weinmann Arndt; Krammer Peter H; Galle Peter R
Suppression of Mcl-1 via RNA interference sensitizes human hepatocellular carcinoma cells towards apoptosis induction.
BMC cancer 2006;6():232.
2006: Fas Stefanie C; Fritzsching Benedikt; Suri-Payer Elisabeth; Krammer Peter H
Death receptor signaling and its function in the immune system.
Current directions in autoimmunity 2006;9():1-17.
2005: Brenner Dirk; Golks Alexander; Kiefer Friedemann; Krammer Peter H; Arnold Rüdiger
Activation or suppression of NFkappaB by HPK1 determines sensitivity to activation-induced cell death.
The EMBO journal 2005;24(24):4279-90.
2005: Herzer Kerstin; Weyer Sandra; Krammer Peter H; Galle Peter R; Hofmann Thomas G
Hepatitis C virus core protein inhibits tumor suppressor protein promyelocytic leukemia function in human hepatoma cells.
Cancer research 2005;65(23):10830-7.
2005: Müller M; Schilling T; Sayan A E; Kairat A; Lorenz K; Schulze-Bergkamen H; Oren M; Koch A; Tannapfel A; Stremmel W; Melino G; Krammer P H
TAp73/Delta Np73 influences apoptotic response, chemosensitivity and prognosis in hepatocellular carcinoma.
Cell death and differentiation 2005;12(12):1564-77.
2005: Haas Jürgen; Hug Andreas; Viehöver Andrea; Fritzsching Benedikt; Falk Christine S; Filser Andrea; Vetter Tina; Milkova Linda; Korporal Mirjam; Fritz Brigitte; Storch-Hagenlocher Brigitte; Krammer Peter H; Suri-Payer Elisabeth; Wildemann Brigitte
Reduced suppressive effect of CD4+CD25high regulatory T cells on the T cell immune response against myelin oligodendrocyte glycoprotein in patients with multiple sclerosis.
European journal of immunology 2005;35(11):3343-52.
2005: Igney Frederik H; Krammer Peter H
Tumor counterattack: fact or fiction?
Cancer immunology, immunotherapy : CII 2005;54(11):1127-36.
2005: Lavrik Inna N; Golks Alexander; Krammer Peter H
Caspases: pharmacological manipulation of cell death.
The Journal of clinical investigation 2005;115(10):2665-72.
2005: Li-Weber Min; Treiber Monika K; Giaisi Marco; Palfi Katalin; Stephan Nadja; Parg Simone; Krammer Peter H
Ultraviolet irradiation suppresses T cell activation via blocking TCR-mediated ERK and NF-kappa B signaling pathways.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(4):2132-43.
2005: Fritzsching Benedikt; Oberle Nina; Eberhardt Nadine; Quick Sabine; Haas Jürgen; Wildemann Brigitte; Krammer Peter H; Suri-Payer Elisabeth
In contrast to effector T cells, CD4+CD25+FoxP3+ regulatory T cells are highly susceptible to CD95 ligand- but not to TCR-mediated cell death.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(1):32-6.
2005: Herzer Kerstin; Ganten Tom M; Schulze-Bergkamen Henning; Grosse-Wilde Anne; Koschny Ronald; Krammer Peter H; Walczak Henning
Transforming growth factor beta can mediate apoptosis via the expression of TRAIL in human hepatoma cells.
Hepatology (Baltimore, Md.) 2005;42(1):183-92.
2005: Gressner Olav; Schilling Tobias; Lorenz Katja; Schulze Schleithoff Elisa; Koch Andreas; Schulze-Bergkamen Henning; Lena Anna Maria; Candi Eleonora; Terrinoni Alessandro; Catani Maria Valeria; Oren Moshe; Melino Gerry; Krammer Peter H; Stremmel Wolfgang; Müller Martina
TAp63alpha induces apoptosis by activating signaling via death receptors and mitochondria.
The EMBO journal 2005;24(13):2458-71.
2005: Baumann Sven; Dostert Anja; Novac Natalia; Bauer Anton; Schmid Wolfgang; Fas Stefanie C; Krueger Andreas; Heinzel Thorsten; Kirchhoff Sabine; Schütz Günther; Krammer Peter H
Glucocorticoids inhibit activation-induced cell death (AICD) via direct DNA-dependent repression of the CD95 ligand gene by a glucocorticoid receptor dimer.
Blood 2005;106(2):617-25.
2005: Proksch Peter; Giaisi Marco; Treiber Monika K; Palfi Katalin; Merling Anette; Spring Herbert; Krammer Peter H; Li-Weber Min
Rocaglamide derivatives are immunosuppressive phytochemicals that target NF-AT activity in T cells.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(11):7075-84.
2005: Gülow Karsten; Kaminski Marcin; Darvas Katalin; Süss Dorothee; Li-Weber Min; Krammer Peter H
HIV-1 trans-activator of transcription substitutes for oxidative signaling in activation-induced T cell death.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(9):5249-60.
2005: Golks Alexander; Brenner Dirk; Fritsch Cornelius; Krammer Peter H; Lavrik Inna N
c-FLIPR, a new regulator of death receptor-induced apoptosis.
The Journal of biological chemistry 2005;280(15):14507-13.
2005: Li-Weber M; Palfi K; Giaisi M; Krammer P H
Dual role of the anti-inflammatory sesquiterpene lactone: regulation of life and death by parthenolide.
Cell death and differentiation 2005;12(4):408-9.
2005: Lavrik Inna; Golks Alexander; Krammer Peter H
Death receptor signaling.
Journal of cell science 2005;118(Pt 2):265-7.
2005: Igney Frederik H; Behrens Christian K; Krammer Peter H
CD95L mediates tumor counterattack in vitro but induces neutrophil-independent tumor rejection in vivo.
International journal of cancer. Journal international du cancer 2005;113(1):78-87.
2004: Bentele M; Lavrik I; Ulrich M; Stösser S; Heermann D W; Kalthoff H; Krammer P H; Eils R
Mathematical modeling reveals threshold mechanism in CD95-induced apoptosis.
The Journal of cell biology 2004;166(6):839-51.
2004: Baumann Sven; Kyewski Bruno; Bleckmann Susanne C; Greiner Erich; Rudolph Dorothea; Schmid Wolfgang; Ramsay Robert G; Krammer Peter H; Schütz Günther; Mantamadiotis Theo
CREB function is required for normal thymic cellularity and post-irradiation recovery.
European journal of immunology 2004;34(7):1961-71.
2004: Ganten T M; Haas T L; Sykora J; Stahl H; Sprick M R; Fas S C; Krueger A; Weigand M A; Grosse-Wilde A; Stremmel W; Krammer P H; Walczak H
Enhanced caspase-8 recruitment to and activation at the DISC is critical for sensitisation of human hepatocellular carcinoma cells to TRAIL-induced apoptosis by chemotherapeutic drugs.
Cell death and differentiation 2004;11 Suppl 1():S86-96.
2004: Shinbori Toshifumi; Walczak Henning; Krammer Peter H
Activated T killer cells induce apoptosis in lung epithelial cells and the release of pro-inflammatory cytokine TNF-alpha.
European journal of immunology 2004;34(6):1762-70.
2004: Eichhorst Sören T; Krueger Andreas; Müerköster Susanne; Fas Stefanie C; Golks Alexander; Gruetzner Uwe; Schubert Louise; Opelz Christine; Bilzer Manfred; Gerbes Alexander L; Krammer Peter H
Suramin inhibits death receptor-induced apoptosis in vitro and fulminant apoptotic liver damage in mice.
Nature medicine 2004;10(6):602-9.
2004: Finzer Patrick; Krueger Andreas; Stöhr Michael; Brenner Dirk; Soto Ubaldo; Kuntzen Christian; Krammer Peter H; Rösl Frank
HDAC inhibitors trigger apoptosis in HPV-positive cells by inducing the E2F-p73 pathway.
Oncogene 2004;23(28):4807-17.
2004: Debatin Klaus-Michael; Krammer Peter H
Death receptors in chemotherapy and cancer.
Oncogene 2004;23(16):2950-66.
2004: Li-Weber Min; Giaisi Marco; Baumann Sven; Pálfi Katalin; Krammer Peter H
NF-kappa B synergizes with NF-AT and NF-IL6 in activation of the IL-4 gene in T cells.
European journal of immunology 2004;34(4):1111-8.
2004: Demjen Deana; Klussmann Stefan; Kleber Susanne; Zuliani Cecilia; Stieltjes Bram; Metzger Corinna; Hirt Ulrich A; Walczak Henning; Falk Werner; Essig Marco; Edler Lutz; Krammer Peter H; Martin-Villalba Ana
Neutralization of CD95 ligand promotes regeneration and functional recovery after spinal cord injury.
Nature medicine 2004;10(4):389-95.
2004: Schulze-Bergkamen Henning; Brenner Dirk; Krueger Andreas; Suess Dorothee; Fas Stefanie C; Frey Christian R; Dax Andreas; Zink Dorothea; Büchler Peter; Müller Martina; Krammer Peter H
Hepatocyte growth factor induces Mcl-1 in primary human hepatocytes and inhibits CD95-mediated apoptosis via Akt.
Hepatology (Baltimore, Md.) 2004;39(3):645-54.
2004: Schulze-Bergkamen Henning; Krammer Peter H
Apoptosis in cancer--implications for therapy.
Seminars in oncology 2004;31(1):90-119.
2004: Schmitz Ingo; Weyd Heiko; Krueger Andreas; Baumann Sven; Fas Stefanie C; Krammer Peter H; Kirchhoff Sabine
Resistance of short term activated T cells to CD95-mediated apoptosis correlates with de novo protein synthesis of c-FLIPshort.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(4):2194-200.
2004: Okouoyo Stella; Herzer Kerstin; Ucur Esat; Mattern Jürgen; Krammer Peter H; Debatin Klaus-Michael; Herr Ingrid
Rescue of death receptor and mitochondrial apoptosis signaling in resistant human NSCLC in vivo.
International journal of cancer. Journal international du cancer 2004;108(4):580-7.
2003: Igney Frederik H; Behrens Christian K; Krammer Peter H
The influence of CD95L expression on tumor rejection in mice.
European journal of immunology 2003;33(10):2811-21.
2003: Schmitz Ingo; Krueger Andreas; Baumann Sven; Schulze-Bergkamen Henning; Krammer Peter H; Kirchhoff Sabine
An IL-2-dependent switch between CD95 signaling pathways sensitizes primary human T cells toward CD95-mediated activation-induced cell death.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(6):2930-6.
2003: Herzer Kerstin; Falk Christine S; Encke Jens; Eichhorst Sören T; Ulsenheimer Axel; Seliger Barbara; Krammer Peter H
Upregulation of major histocompatibility complex class I on liver cells by hepatitis C virus core protein via p53 and TAP1 impairs natural killer cell cytotoxicity.
Journal of virology 2003;77(15):8299-309.
2003: Li-Weber Min; Krammer Peter H
Regulation of IL4 gene expression by T cells and therapeutic perspectives.
Nature reviews. Immunology 2003;3(7):534-43.
2003: Li-Weber Min; Krammer Peter H
Function and regulation of the CD95 (APO-1/Fas) ligand in the immune system.
Seminars in immunology 2003;15(3):145-57.
2003: Herr Ingrid; Ucur Esat; Herzer Kerstin; Okouoyo Stella; Ridder Rüdiger; Krammer Peter H; von Knebel Doeberitz Magnus; Debatin Klaus-Michael
Glucocorticoid cotreatment induces apoptosis resistance toward cancer therapy in carcinomas.
Cancer research 2003;63(12):3112-20.
2003: Schulze-Bergkamen Henning; Untergasser Andreas; Dax Andreas; Vogel Heiko; Büchler Peter; Klar Ernst; Lehnert Thomas; Friess Helmut; Büchler Markus W; Kirschfink Michael; Stremmel Wolfgang; Krammer Peter H; Müller Martina; Protzer Ulrike
Primary human hepatocytes--a valuable tool for investigation of apoptosis and hepatitis B virus infection.
Journal of hepatology 2003;38(6):736-44.
2003: Krueger Andreas; Fas Stefanie C; Baumann Sven; Krammer Peter H
The role of CD95 in the regulation of peripheral T-cell apoptosis.
Immunological reviews 2003;193():58-69.
2003: Baumann Sven; Hess Jochen; Eichhorst Sören T; Krueger Andreas; Angel Peter; Krammer Peter H; Kirchhoff Sabine
An unexpected role for FosB in activation-induced cell death of T cells.
Oncogene 2003;22(9):1333-9.
2003: Lavrik I; Krueger A; Schmitz I; Baumann S; Weyd H; Krammer P H; Kirchhoff S
The active caspase-8 heterotetramer is formed at the CD95 DISC.
Cell death and differentiation 2003;10(1):144-5.
2003: Dienz Oliver; Möller Andreas; Strecker Andreas; Stephan Nadja; Krammer Peter H; Dröge Wulf; Schmitz M Lienhard
Src homology 2 domain-containing leukocyte phosphoprotein of 76 kDa and phospholipase C gamma 1 are required for NF-kappa B activation and lipid raft recruitment of protein kinase C theta induced by T cell costimulation.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(1):365-72.
2002: Li-Weber Min; Giaisi Marco; Treiber Monika K; Krammer Peter H
The anti-inflammatory sesquiterpene lactone parthenolide suppresses IL-4 gene expression in peripheral blood T.
European journal of immunology 2002;32(12):3587-97.
2002: Elser Bernd; Lohoff Michael; Kock Sonja; Giaisi Marco; Kirchhoff Sabine; Krammer Peter H; Li-Weber Min
IFN-gamma represses IL-4 expression via IRF-1 and IRF-2.
Immunity 2002;17(6):703-12.
2002: Li-Weber M; Giaisi M; Baumann S; Treiber M K; Krammer P H
The anti-inflammatory sesquiterpene lactone parthenolide suppresses CD95-mediated activation-induced-cell-death in T-cells.
Cell death and differentiation 2002;9(11):1256-65.
2002: Schmitz Ingo; Krueger Andreas; Baumann Sven; Kirchhoff Sabine; Krammer Peter H
Specificity of anti-human CD95 (APO-1/Fas) antibodies.
Biochemical and biophysical research communications 2002;297(3):459-62.
2002: Li-Weber Min; Weigand Markus A; Giaisi Marco; Süss Dorothee; Treiber Monika K; Baumann Sven; Ritsou Elena; Breitkreutz Raoul; Krammer Peter H
Vitamin E inhibits CD95 ligand expression and protects T cells from activation-induced cell death.
The Journal of clinical investigation 2002;110(5):681-90.
2002: Li-Weber Min; Giaisi Marco; Treiber Monika K; Krammer Peter H
Vitamin E inhibits IL-4 gene expression in peripheral blood T cells.
European journal of immunology 2002;32(9):2401-8.
2002: Igney Frederik H; Krammer Peter H
Immune escape of tumors: apoptosis resistance and tumor counterattack.
Journal of leukocyte biology 2002;71(6):907-20.
2002: Baumann Sven; Krueger Andreas; Kirchhoff Sabine; Krammer Peter H
Regulation of T cell apoptosis during the immune response.
Current molecular medicine 2002;2(3):257-72.
2002: Igney Frederik H; Krammer Peter H
Death and anti-death: tumour resistance to apoptosis.
Nature reviews. Cancer 2002;2(4):277-88.
2002: Duverger Valerie; Sartorius Ute; Klein-Bauernschmitt Petra; Krammer Peter H; Schlehofer Jörg R
Enhancement of cisplatin-induced apoptosis by infection with adeno-associated virus type 2.
International journal of cancer. Journal international du cancer 2002;97(5):706-12.
2002: Sartorius Ute A; Krammer Peter H
Upregulation of Bcl-2 is involved in the mediation of chemotherapy resistance in human small cell lung cancer cell lines.
International journal of cancer. Journal international du cancer 2002;97(5):584-92.
2002: Kirchhoff Sabine; Sebens Thorsten; Baumann Sven; Krueger Andreas; Zawatzky Rainer; Li-Weber Min; Meinl Edgar; Neipel Frank; Fleckenstein Bernhard; Krammer Peter H
Viral IFN-regulatory factors inhibit activation-induced cell death via two positive regulatory IFN-regulatory factor 1-dependent domains in the CD95 ligand promoter.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(3):1226-34.
2002: Hentze Hannes; Schmitz Ingo; Latta Markus; Krueger Andreas; Krammer Peter H; Wendel Albrecht
Glutathione dependence of caspase-8 activation at the death-inducing signaling complex.
The Journal of biological chemistry 2002;277(7):5588-95.
2002: Aguilar-Lemarroy Adriana; Gariglio Patricio; Whitaker Noel J; Eichhorst Sören T; zur Hausen Harald; Krammer Peter H; Rösl Frank
Restoration of p53 expression sensitizes human papillomavirus type 16 immortalized human keratinocytes to CD95-mediated apoptosis.
Oncogene 2002;21(2):165-75.
2001: Li-Weber M; Giaisi M; Krammer P H
Roles of CCAAT/enhancer-binding protein in transcriptional regulation of the human IL-5 gene.
European journal of immunology 2001;31(12):3694-703.
2001: Eckhart L; Henry M; Santos-Beneit A M; Schmitz I; Krueger A; Fischer H; Bach J; Ban J; Kirchhoff S; Krammer P H; Mollinedo F; Tschachler E
Alternative splicing of caspase-8 mRNA during differentiation of human leukocytes.
Biochemical and biophysical research communications 2001;289(4):777-81.
2001: Krueger A; Baumann S; Krammer P H; Kirchhoff S
FLICE-inhibitory proteins: regulators of death receptor-mediated apoptosis.
Molecular and cellular biology 2001;21(24):8247-54.
2001: Chatterjee D; Schmitz I; Krueger A; Yeung K; Kirchhoff S; Krammer P H; Peter M E; Wyche J H; Pantazis P
Induction of apoptosis in 9-nitrocamptothecin-treated DU145 human prostate carcinoma cells correlates with de novo synthesis of CD95 and CD95 ligand and down-regulation of c-FLIP(short).
Cancer research 2001;61(19):7148-54.
2001: Haberkorn U; Kinscherf R; Krammer P H; Mier W; Eisenhut M
Investigation of a potential scintigraphic marker of apoptosis: radioiodinated Z-Val-Ala-DL-Asp(O-methyl)-fluoromethyl ketone.
Nuclear medicine and biology 2001;28(7):793-8.
2001: Nakayama N; Eichhorst S T; Müller M; Krammer P H
Ethanol-induced apoptosis in hepatoma cells proceeds via intracellular Ca(2+) elevation, activation of TLCK-sensitive proteases, and cytochrome c release.
Experimental cell research 2001;269(2):202-13.
2001: Li-Weber M; Giaisi M; Chlichlia K; Khazaie K; Krammer P H
Human T cell leukemia virus type I Tax enhances IL-4 gene expression in T cells.
European journal of immunology 2001;31(9):2623-32.
2001: Aguilar-Lemarroy A; Kirchhoff S; Whitaker N; Gariglio P; zur Hausen H; Krammer P H; Rösl F
Differential sensitivity of human papillomavirus type 16(+) and type 18(+) cervical carcinoma cells to CD95-mediated apoptosis.
International journal of cancer. Journal international du cancer 2001;93(6):823-31.
2001: Kuck D; Kolmerer B; Iking-Konert C; Krammer P H; Stremmel W; Rudi J
Vacuolating cytotoxin of Helicobacter pylori induces apoptosis in the human gastric epithelial cell line AGS.
Infection and immunity 2001;69(8):5080-7.
2001: Martin-Villalba A; Hahne M; Kleber S; Vogel J; Falk W; Schenkel J; Krammer P H
Therapeutic neutralization of CD95-ligand and TNF attenuates brain damage in stroke.
Cell death and differentiation 2001;8(7):679-86.
2001: Ehret A; Li-Weber M; Frank R; Krammer P H
The effect of HIV-1 regulatory proteins on cellular genes: derepression of the IL-2 promoter by Tat.
European journal of immunology 2001;31(6):1790-9.
2001: Krueger A; Schmitz I; Baumann S; Krammer P H; Kirchhoff S
Cellular FLICE-inhibitory protein splice variants inhibit different steps of caspase-8 activation at the CD95 death-inducing signaling complex.
The Journal of biological chemistry 2001;276(23):20633-40.
2001: Behrens C K; Igney F H; Arnold B; Möller P; Krammer P H
CD95 ligand-expressing tumors are rejected in anti-tumor TCR transgenic perforin knockout mice.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(5):3240-7.
2001: Sartorius U; Schmitz I; Krammer P H
Molecular mechanisms of death-receptor-mediated apoptosis.
Chembiochem : a European journal of chemical biology 2001;2(1):20-9.
2001: Eichhorst S T; Müerköster S; Weigand M A; Krammer P H
The chemotherapeutic drug 5-fluorouracil induces apoptosis in mouse thymocytes in vivo via activation of the CD95(APO-1/Fas) system.
Cancer research 2001;61(1):243-8.
2000: Kirchhoff S; Müller W W; Krueger A; Schmitz I; Krammer P H
TCR-mediated up-regulation of c-FLIPshort correlates with resistance toward CD95-mediated apoptosis by blocking death-inducing signaling complex activity.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(11):6293-300.
2000: Schmitz I; Kirchhoff S; Krammer P H
Regulation of death receptor-mediated apoptosis pathways.
The international journal of biochemistry & cell biology 2000;32(11-12):1123-36.
2000: Kirchhoff S; Müller W W; Li-Weber M; Krammer P H
Up-regulation of c-FLIPshort and reduction of activation-induced cell death in CD28-costimulated human T cells.
European journal of immunology 2000;30(10):2765-74.
2000: Krammer P H
CD95's deadly mission in the immune system.
Nature 2000;407(6805):789-95.
2000: Eichhorst S T; Müller M; Li-Weber M; Schulze-Bergkamen H; Angel P; Krammer P H
A novel AP-1 element in the CD95 ligand promoter is required for induction of apoptosis in hepatocellular carcinoma cells upon treatment with anticancer drugs.
Molecular and cellular biology 2000;20(20):7826-37.
2000: Stegh A H; Herrmann H; Lampel S; Weisenberger D; Andrä K; Seper M; Wiche G; Krammer P H; Peter M E
Identification of the cytolinker plectin as a major early in vivo substrate for caspase 8 during CD95- and tumor necrosis factor receptor-mediated apoptosis.
Molecular and cellular biology 2000;20(15):5665-79.
2000: Sprick M R; Weigand M A; Rieser E; Rauch C T; Juo P; Blenis J; Krammer P H; Walczak H
FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2.
Immunity 2000;12(6):599-609.
2000: Walczak H; Bouchon A; Stahl H; Krammer P H
Tumor necrosis factor-related apoptosis-inducing ligand retains its apoptosis-inducing capacity on Bcl-2- or Bcl-xL-overexpressing chemotherapy-resistant tumor cells.
Cancer research 2000;60(11):3051-7.
2000: Willems F; Amraoui Z; Vanderheyde N; Verhasselt V; Aksoy E; Scaffidi C; Peter M E; Krammer P H; Goldman M
Expression of c-FLIP(L) and resistance to CD95-mediated apoptosis of monocyte-derived dendritic cells: inhibition by bisindolylmaleimide.
Blood 2000;95(11):3478-82.
2000: Walczak H; Krammer P H
The CD95 (APO-1/Fas) and the TRAIL (APO-2L) apoptosis systems.
Experimental cell research 2000;256(1):58-66.
2000: Hehner S P; Li-Weber M; Giaisi M; Dröge W; Krammer P H; Schmitz M L
Vav synergizes with protein kinase C theta to mediate IL-4 gene expression in response to CD28 costimulation in T cells.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(7):3829-36.
2000: Igney F H; Behrens C K; Krammer P H
Tumor counterattack--concept and reality.
European journal of immunology 2000;30(3):725-31.
2000: Li-Weber M; Laur O; Dern K; Krammer P H
T cell activation-induced and HIV tat-enhanced CD95(APO-1/Fas) ligand transcription involves NF-kappaB.
European journal of immunology 2000;30(2):661-70.
2000: Scaffidi C; Volkland J; Blomberg I; Hoffmann I; Krammer P H; Peter M E
Phosphorylation of FADD/ MORT1 at serine 194 and association with a 70-kDa cell cycle-regulated protein kinase.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(3):1236-42.
2000: Bouchon A; Krammer P H; Walczak H
Critical role for mitochondria in B cell receptor-mediated apoptosis.
European journal of immunology 2000;30(1):69-77.
1999: Raftery M J; Behrens C K; Müller A; Krammer P H; Walczak H; Schönrich G
Herpes simplex virus type 1 infection of activated cytotoxic T cells: Induction of fratricide as a mechanism of viral immune evasion.
The Journal of experimental medicine 1999;190(8):1103-14.
1999: Schmitz I; Walczak H; Krammer P H; Peter M E
Differences between CD95 type I and II cells detected with the CD95 ligand.
Cell death and differentiation 1999;6(9):821-2.
1999: Li-Weber M; Laur O; Krammer P H
Novel Egr/NF-AT composite sites mediate activation of the CD95 (APO-1/Fas) ligand promoter in response to T cell stimulation.
European journal of immunology 1999;29(9):3017-27.
1999: Scaffidi C; Schmitz I; Zha J; Korsmeyer S J; Krammer P H; Peter M E
Differential modulation of apoptosis sensitivity in CD95 type I and type II cells.
The Journal of biological chemistry 1999;274(32):22532-8.
1999: Scaffidi C; Kirchhoff S; Krammer P H; Peter M E
Apoptosis signaling in lymphocytes.
Current opinion in immunology 1999;11(3):277-85.
1999: Scaffidi C; Krammer P H; Peter M E
Isolation and analysis of components of CD95 (APO-1/Fas) death-inducing signaling complex.
Methods (San Diego, Calif.) 1999;17(4):287-91.
1999: Scaffidi C; Schmitz I; Krammer P H; Peter M E
The role of c-FLIP in modulation of CD95-induced apoptosis.
The Journal of biological chemistry 1999;274(3):1541-8.
1999: Peter M E; Scaffidi C; Medema J P; Kischkel F; Krammer P H
The death receptors.
Results and problems in cell differentiation 1999;23():25-63.
1999: Krammer P H
CD95(APO-1/Fas)-mediated apoptosis: live and let die.
Advances in immunology 1999;71():163-210.
1998: Müller M; Scaffidi C A; Galle P R; Stremmel W; Krammer P H
The role of p53 and the CD95 (APO-1/Fas) death system in chemotherapy-induced apoptosis.
European cytokine network 1998;9(4):685-6.
1998: Fulda S; Scaffidi C; Susin S A; Krammer P H; Kroemer G; Peter M E; Debatin K M
Activation of mitochondria and release of mitochondrial apoptogenic factors by betulinic acid.
The Journal of biological chemistry 1998;273(51):33942-8.
1998: Müller M; Wilder S; Bannasch D; Israeli D; Lehlbach K; Li-Weber M; Friedman S L; Galle P R; Stremmel W; Oren M; Krammer P H
p53 activates the CD95 (APO-1/Fas) gene in response to DNA damage by anticancer drugs.
The Journal of experimental medicine 1998;188(11):2033-45.
1998: Li-Weber M; Giasi M; Krammer P H
Involvement of Jun and Rel proteins in up-regulation of interleukin-4 gene activity by the T cell accessory molecule CD28.
The Journal of biological chemistry 1998;273(49):32460-6.
1998: Fulda S; Scaffidi C; Pietsch T; Krammer P H; Peter M E; Debatin K M
Activation of the CD95 (APO-1/Fas) pathway in drug- and gamma-irradiation-induced apoptosis of brain tumor cells.
Cell death and differentiation 1998;5(10):884-93.
1998: Peter M E; Krammer P H
Mechanisms of CD95 (APO-1/Fas)-mediated apoptosis.
Current opinion in immunology 1998;10(5):545-51.
1998: Rudi J; Kuck D; Strand S; von Herbay A; Mariani S M; Krammer P H; Galle P R; Stremmel W
Involvement of the CD95 (APO-1/Fas) receptor and ligand system in Helicobacter pylori-induced gastric epithelial apoptosis.
The Journal of clinical investigation 1998;102(8):1506-14.
1998: Stegh A H; Schickling O; Ehret A; Scaffidi C; Peterhänsel C; Hofmann T G; Grummt I; Krammer P H; Peter M E
DEDD, a novel death effector domain-containing protein, targeted to the nucleolus.
The EMBO journal 1998;17(20):5974-86.
1998: Li-Weber M; Laur O; Hekele A; Coy J; Walczak H; Krammer P H
A regulatory element in the CD95 (APO-1/Fas) ligand promoter is essential for responsiveness to TCR-mediated activation.
European journal of immunology 1998;28(8):2373-83.
1998: Li-Weber M; Salgame P; Hu C; Davydov I V; Laur O; Klevenz S; Krammer P H
Th2-specific protein/DNA interactions at the proximal nuclear factor-AT site contribute to the functional activity of the human IL-4 promoter.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(3):1380-9.
1998: Chlichlia K; Peter M E; Rocha M; Scaffidi C; Bucur M; Krammer P H; Schirrmacher V; Umansky V
Caspase activation is required for nitric oxide-mediated, CD95(APO-1/Fas)-dependent and independent apoptosis in human neoplastic lymphoid cells.
Blood 1998;91(11):4311-20.
1998: Mariani S M; Krammer P H
Surface expression of TRAIL/Apo-2 ligand in activated mouse T and B cells.
European journal of immunology 1998;28(5):1492-8.
1998: Strand S; Hofmann W J; Grambihler A; Hug H; Volkmann M; Otto G; Wesch H; Mariani S M; Hack V; Stremmel W; Krammer P H; Galle P R
Hepatic failure and liver cell damage in acute Wilson's disease involve CD95 (APO-1/Fas) mediated apoptosis.
Nature medicine 1998;4(5):588-93.
1998: Stricker K; Knipping E; Böhler T; Benner A; Krammer P H; Debatin K M
Anti-CD95 (APO-1/Fas) autoantibodies and T cell depletion in human immunodeficiency virus type 1 (HIV-1)-infected children.
Cell death and differentiation 1998;5(3):222-30.
1998: Mariani S M; Krammer P H
Differential regulation of TRAIL and CD95 ligand in transformed cells of the T and B lymphocyte lineage.
European journal of immunology 1998;28(3):973-82.
1998: Scaffidi C; Fulda S; Srinivasan A; Friesen C; Li F; Tomaselli K J; Debatin K M; Krammer P H; Peter M E
Two CD95 (APO-1/Fas) signaling pathways.
The EMBO journal 1998;17(6):1675-87.
1998: Medema J P; Scaffidi C; Krammer P H; Peter M E
Bcl-xL acts downstream of caspase-8 activation by the CD95 death-inducing signaling complex.
The Journal of biological chemistry 1998;273(6):3388-93.
1998: Kischkel F C; Kioschis P; Weitz S; Poustka A; Lichter P; Krammer P H
Assignment of CASP8 to human chromosome band 2q33-->q34 and Casp8 to the murine syntenic region on chromosome 1B-proximal C by in situ hybridization.
Cytogenetics and cell genetics 1998;82(1-2):95-6.
1997: Medema J P; Toes R E; Scaffidi C; Zheng T S; Flavell R A; Melief C J; Peter M E; Offringa R; Krammer P H
Cleavage of FLICE (caspase-8) by granzyme B during cytotoxic T lymphocyte-induced apoptosis.
European journal of immunology 1997;27(12):3492-8.
1997: Li-Weber M; Laur O; Davydov I; Hu C; Salgame P; Krammer P H
What controls tissue-specific expression of the IL-4 gene?
Immunobiology 1997;198(1-3):170-8.
1997: Fulda S; Friesen C; Los M; Scaffidi C; Mier W; Benedict M; Nuñez G; Krammer P H; Peter M E; Debatin K M
Betulinic acid triggers CD95 (APO-1/Fas)- and p53-independent apoptosis via activation of caspases in neuroectodermal tumors.
Cancer research 1997;57(21):4956-64.
1997: Hug H; Strand S; Grambihler A; Galle J; Hack V; Stremmel W; Krammer P H; Galle P R
Reactive oxygen intermediates are involved in the induction of CD95 ligand mRNA expression by cytostatic drugs in hepatoma cells.
The Journal of biological chemistry 1997;272(45):28191-3.
1997: Peter M E; Medema J P; Krammer P H
Does the Caenorhabditis elegans protein CED-4 contain a region of homology to the mammalian death effector domain?
Cell death and differentiation 1997;4(7):523-5.
1997: Scaffidi C; Medema J P; Krammer P H; Peter M E
FLICE is predominantly expressed as two functionally active isoforms, caspase-8/a and caspase-8/b.
The Journal of biological chemistry 1997;272(43):26953-8.
1997: Medema J P; Scaffidi C; Kischkel F C; Shevchenko A; Mann M; Krammer P H; Peter M E
FLICE is activated by association with the CD95 death-inducing signaling complex (DISC).
The EMBO journal 1997;16(10):2794-804.
1997: Chlichlia K; Busslinger M; Peter M E; Walczak H; Krammer P H; Schirrmacher V; Khazaie K
ICE-proteases mediate HTLV-I Tax-induced apoptotic T-cell death.
Oncogene 1997;14(19):2265-72.
1997: Peter M E; Kischkel F C; Scheuerpflug C G; Medema J P; Debatin K M; Krammer P H
Resistance of cultured peripheral T cells towards activation-induced cell death involves a lack of recruitment of FLICE (MACH/caspase 8) to the CD95 death-inducing signaling complex.
European journal of immunology 1997;27(5):1207-12.
1997: Li-Weber M; Salgame P; Hu C; Krammer P H
Characterization of constitutive and inducible transcription factors binding to the P2 NF-AT site in the human interleukin-4 promoter.
Gene 1997;188(2):253-60.
1997: Mariani S M; Matiba B; Armandola E A; Krammer P H
Interleukin 1 beta-converting enzyme related proteases/caspases are involved in TRAIL-induced apoptosis of myeloma and leukemia cells.
The Journal of cell biology 1997;137(1):221-9.
1997: Thome M; Schneider P; Hofmann K; Fickenscher H; Meinl E; Neipel F; Mattmann C; Burns K; Bodmer J L; Schröter M; Scaffidi C; Krammer P H; Peter M E; Tschopp J
Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors.
Nature 1997;386(6624):517-21.
1997: Matiba B; Mariani S M; Krammer P H
The CD95 system and the death of a lymphocyte.
Seminars in immunology 1997;9(1):59-68.
1997: Müller M; Strand S; Hug H; Heinemann E M; Walczak H; Hofmann W J; Stremmel W; Krammer P H; Galle P R
Drug-induced apoptosis in hepatoma cells is mediated by the CD95 (APO-1/Fas) receptor/ligand system and involves activation of wild-type p53.
The Journal of clinical investigation 1997;99(3):403-13.
1997: Li-Weber M; Salgame P; Hu C; Davydov I V; Krammer P H
Differential interaction of nuclear factors with the PRE-I enhancer element of the human IL-4 promoter in different T cell subsets.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(3):1194-200.
1997: Peter M E; Ehret A; Berndt C; Krammer P H
AIDS and the death receptors.
British medical bulletin 1997;53(3):604-16.
1996: Sträter J; Walczak H; Krammer P H; Möller P
Simultaneous in situ detection of mRNA and apoptotic cells by combined hybridization and TUNEL.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1996;44(12):1497-9.
1996: Strand S; Hofmann W J; Hug H; Müller M; Otto G; Strand D; Mariani S M; Stremmel W; Krammer P H; Galle P R
Lymphocyte apoptosis induced by CD95 (APO-1/Fas) ligand-expressing tumor cells--a mechanism of immune evasion?
Nature medicine 1996;2(12):1361-6.
1996: Cahill M A; Peter M E; Kischkel F C; Chinnaiyan A M; Dixit V M; Krammer P H; Nordheim A
CD95 (APO-1/Fas) induces activation of SAP kinases downstream of ICE-like proteases.
Oncogene 1996;13(10):2087-96.
1996: Mariani S M; Matiba B; Krammer P H
CD95 (APO-1/Fas) and its ligand in the mouse immune system.
Behring Institute Mitteilungen 1996;(97):12-23.
1996: Bäumler C B; Böhler T; Herr I; Benner A; Krammer P H; Debatin K M
Activation of the CD95 (APO-1/Fas) system in T cells from human immunodeficiency virus type-1-infected children.
Blood 1996;88(5):1741-6.
1996: Ehret A; Westendorp M O; Herr I; Debatin K M; Heeney J L; Frank R; Krammer P H
Resistance of chimpanzee T cells to human immunodeficiency virus type 1 Tat-enhanced oxidative stress and apoptosis.
Journal of virology 1996;70(9):6502-7.
1996: Günthert A R; Sträter J; von Reyher U; Henne C; Joos S; Koretz K; Moldenhauer G; Krammer P H; Möller P
Early detachment of colon carcinoma cells during CD95(APO-1/Fas)-mediated apoptosis. I. De-adhesion from hyaluronate by shedding of CD44.
The Journal of cell biology 1996;134(4):1089-96.
1996: Ratter F; Germer M; Fischbach T; Schulze-Osthoff K; Peter M E; Dröge W; Krammer P H; Lehmann V
S-adenosylhomocysteine as a physiological modulator of Apo-1-mediated apoptosis.
International immunology 1996;8(7):1139-47.
1996: Möller P; Walczak H; Reidl S; Sträter J; Krammer P H
Paneth cells express high levels of CD95 ligand transcripts: a unique property among gastrointestinal epithelia.
The American journal of pathology 1996;149(1):9-13.
1996: Mariani S M; Matiba B; Sparna T; Krammer P H
Expression of biologically active mouse and human CD95/APO-1/Fas ligand in the baculovirus system.
Journal of immunological methods 1996;193(1):63-70.
1996: Muzio M; Chinnaiyan A M; Kischkel F C; O'Rourke K; Shevchenko A; Ni J; Scaffidi C; Bretz J D; Zhang M; Gentz R; Mann M; Krammer P H; Peter M E; Dixit V M
FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex.
Cell 1996;85(6):817-27.
1996: Friesen C; Herr I; Krammer P H; Debatin K M
Involvement of the CD95 (APO-1/FAS) receptor/ligand system in drug-induced apoptosis in leukemia cells.
Nature medicine 1996;2(5):574-7.
1996: Walczak H; Dhein J; Peter M E; Krammer P H
Educational Corner: Activation-induced T cell death.
Cell death and differentiation 1996;3(2):245.
1996: Peter M E; Kischkel F C; Hellbardt S; Chinnaiyan A M; Krammer P H; Dixit V M
CD95 (APO-1/Fas)-associating signalling proteins.
Cell death and differentiation 1996;3(2):161-70.
1996: Krammer P H
The CD95(APO-1/Fas) receptor/ligand system: death signals and diseases.
Cell death and differentiation 1996;3(2):159-60.
1996: Chinnaiyan A M; Tepper C G; Seldin M F; O'Rourke K; Kischkel F C; Hellbardt S; Krammer P H; Peter M E; Dixit V M
FADD/MORT1 is a common mediator of CD95 (Fas/APO-1) and tumor necrosis factor receptor-induced apoptosis.
The Journal of biological chemistry 1996;271(9):4961-5.
1996: Sträter J; Walczak H; Wellisch I; Riedl S; Koretz K; Krammer P H; Möller P
[Normal colon epithelium is highly sensitive to CD95-induced apoptosis. Indication for a role of cell death-induced CD95/CL95L systems under inflammatory inflammatory conditions?]
Verhandlungen der Deutschen Gesellschaft für Pathologie 1996;80():217.
1995: Knipping E; Krammer P H; Onel K B; Lehman T J; Mysler E; Elkon K B
Levels of soluble Fas/APO-1/CD95 in systemic lupus erythematosus and juvenile rheumatoid arthritis.
Arthritis and rheumatism 1995;38(12):1735-7.
1995: Davydov I V; Krammer P H; Li-Weber M
Nuclear factor-IL6 activates the human IL-4 promoter in T cells.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(11):5273-9.
1995: Peter M E; Dhein J; Ehret A; Hellbardt S; Walczak H; Moldenhauer G; Krammer P H
APO-1 (CD95)-dependent and -independent antigen receptor-induced apoptosis in human T and B cell lines.
International immunology 1995;7(11):1873-7.
1995: Kischkel F C; Hellbardt S; Behrmann I; Germer M; Pawlita M; Krammer P H; Peter M E
Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor.
The EMBO journal 1995;14(22):5579-88.
1995: Müller K P; Mariani S M; Matiba B; Kyewski B; Krammer P H
Clonal deletion of major histocompatibility complex class I-restricted CD4+CD8+ thymocytes in vitro is independent of the CD95 (APO-1/Fas) ligand.
European journal of immunology 1995;25(10):2996-9.
1995: Davydov I V; Bohmann D; Krammer P H; Li-Weber M
Cloning of the cDNA encoding human C/EBP gamma, a protein binding to the PRE-I enhancer element of the human interleukin-4 promoter.
Gene 1995;161(2):271-5.
1995: Mariani S M; Matiba B; Bäumler C; Krammer P H
Regulation of cell surface APO-1/Fas (CD95) ligand expression by metalloproteases.
European journal of immunology 1995;25(8):2303-7.
1995: Rensing-Ehl A; Frei K; Flury R; Matiba B; Mariani S M; Weller M; Aebischer P; Krammer P H; Fontana A
Local Fas/APO-1 (CD95) ligand-mediated tumor cell killing in vivo.
European journal of immunology 1995;25(8):2253-8.
1995: Li-Weber M; Davydov I V; Krammer P H
NF-Y, IRF-2, and C/EBP proteins are involved in regulation of human IL-4 gene expression.
Immunobiology 1995;193(2-4):263-7.
1995: Dhein J; Walczak H; Westendorp M O; Bäumler C; Stricker K; Frank R; Debatin K M; Krammer P H
Molecular mechanisms of APO-1/Fas(CD95)-mediated apoptosis in tolerance and AIDS.
Behring Institute Mitteilungen 1995;(96):13-20.
1995: Westendorp M O; Frank R; Ochsenbauer C; Stricker K; Dhein J; Walczak H; Debatin K M; Krammer P H
Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120.
Nature 1995;375(6531):497-500.
1995: Los M; Van de Craen M; Penning L C; Schenk H; Westendorp M; Baeuerle P A; Dröge W; Krammer P H; Fiers W; Schulze-Osthoff K
Requirement of an ICE/CED-3 protease for Fas/APO-1-mediated apoptosis.
Nature 1995;375(6526):81-3.
1995: Knipping E; Debatin K M; Stricker K; Heilig B; Eder A; Krammer P H
Identification of soluble APO-1 in supernatants of human B- and T-cell lines and increased serum levels in B- and T-cell leukemias.
Blood 1995;85(6):1562-9.
1995: Westendorp M O; Shatrov V A; Schulze-Osthoff K; Frank R; Kraft M; Los M; Krammer P H; Dröge W; Lehmann V
HIV-1 Tat potentiates TNF-induced NF-kappa B activation and cytotoxicity by altering the cellular redox state.
The EMBO journal 1995;14(3):546-54.
1995: Dhein J; Walczak H; Bäumler C; Debatin K M; Krammer P H
Autocrine T-cell suicide mediated by APO-1/(Fas/CD95)
Nature 1995;373(6513):438-41.
1995: Praast G; Hofmeister R; Grube K; Hans W; Kühlwein T; Krammer P H; Falk W
The internalized interleukin-1 activation complex in fibroblasts localizes to the Golgi apparatus.
Journal of inflammation 1995;46(3):125-38.
1994: Krammer P H; Dhein J; Walczak H; Behrmann I; Mariani S; Matiba B; Fath M; Daniel P T; Knipping E; Westendorp M O
The role of APO-1-mediated apoptosis in the immune system.
Immunological reviews 1994;142():175-91.
1994: Mariani S M; Matiba B; Armandola E A; Krammer P H
The APO-1/Fas (CD95) receptor is expressed in homozygous MRL/lpr mice.
European journal of immunology 1994;24(12):3119-23.
1994: Behrmann I; Walczak H; Krammer P H
Structure of the human APO-1 gene.
European journal of immunology 1994;24(12):3057-62.
1994: Li-Weber M; Davydov I V; Krafft H; Krammer P H
The role of NF-Y and IRF-2 in the regulation of human IL-4 gene expression.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(9):4122-33.
1994: Lücking-Famira K M; Daniel P T; Möller P; Krammer P H; Debatin K M
APO-1 (CD95) mediated apoptosis in human T-ALL engrafted in SCID mice.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1994;8(11):1825-33.
1994: Schulze-Osthoff K; Walczak H; Dröge W; Krammer P H
Cell nucleus and DNA fragmentation are not required for apoptosis.
The Journal of cell biology 1994;127(1):15-20.
1994: Schulze-Osthoff K; Krammer P H; Dröge W
Divergent signalling via APO-1/Fas and the TNF receptor, two homologous molecules involved in physiological cell death.
The EMBO journal 1994;13(19):4587-96.
1994: Dhein J; Behrmann I; Daniel P T; Debatin K M; Klas C; Möller P; Oehm A; Trauth B C; Walczak H; Krammer P H
APO-I-mediated apoptosis in normal and malignant lymphocytes.
Biochemical Society transactions 1994;22(3):598-600.
1994: Coney L R; Daniel P T; Sanborn D; Dhein J; Debatin K M; Krammer P H; Zurawski V R
Apoptotic cell death induced by a mouse-human anti-APO-1 chimeric antibody leads to tumor regression.
International journal of cancer. Journal international du cancer 1994;58(4):562-7.
1994: Westendorp M O; Li-Weber M; Frank R W; Krammer P H
Human immunodeficiency virus type 1 Tat upregulates interleukin-2 secretion in activated T cells.
Journal of virology 1994;68(7):4177-85.
1994: Falk W; Stricker K; Praast G; Tsukitani Y; Krammer P H; Stoeck M
Activation of the mouse IL-2 gene by okadaic acid: synergy with interleukin-1.
Lymphokine and cytokine research 1994;13(3):167-74.
1994: Daniel P T; Krammer P H
Activation induces sensitivity toward APO-1 (CD95)-mediated apoptosis in human B cells.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(12):5624-32.
1994: Möller P; Koretz K; Leithäuser F; Brüderlein S; Henne C; Quentmeier A; Krammer P H
Expression of APO-1 (CD95), a member of the NGF/TNF receptor superfamily, in normal and neoplastic colon epithelium.
International journal of cancer. Journal international du cancer 1994;57(3):371-7.
1994: Krammer P H; Behrmann I; Daniel P; Dhein J; Debatin K M
Regulation of apoptosis in the immune system.
Current opinion in immunology 1994;6(2):279-89.
1994: Debatin K M; Süss D; Krammer P H
Differential expression of APO-1 on human thymocytes: implications for negative selection?
European journal of immunology 1994;24(3):753-8.
1993: Leithäuser F; Dhein J; Mechtersheimer G; Koretz K; Brüderlein S; Henne C; Schmidt A; Debatin K M; Krammer P H; Möller P
Constitutive and induced expression of APO-1, a new member of the nerve growth factor/tumor necrosis factor receptor superfamily, in normal and neoplastic cells.
Laboratory investigation; a journal of technical methods and pathology 1993;69(4):415-29.
1993: Li-Weber M; Krafft H; Krammer P H
A novel enhancer element in the human IL-4 promoter is suppressed by a position-independent silencer.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(3):1371-82.
1993: Stricker K; Serfling E; Krammer P H; Falk W
An NF-kappa B-like element plays an essential role in interleukin-1-mediated costimulation of the mouse interleukin-2 promoter.
European journal of immunology 1993;23(7):1475-80.
1993: Klas C; Debatin K M; Jonker R R; Krammer P H
Activation interferes with the APO-1 pathway in mature human T cells.
International immunology 1993;5(6):625-30.
1993: Möller P; Henne C; Leithäuser F; Eichelmann A; Schmidt A; Brüderlein S; Dhein J; Krammer P H
Coregulation of the APO-1 antigen with intercellular adhesion molecule-1 (CD54) in tonsillar B cells and coordinate expression in follicular center B cells and in follicle center and mediastinal B-cell lymphomas.
Blood 1993;81(8):2067-75.
1992: Dhein J; Daniel P T; Trauth B C; Oehm A; Möller P; Krammer P H
Induction of apoptosis by monoclonal antibody anti-APO-1 class switch variants is dependent on cross-linking of APO-1 cell surface antigens.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(10):3166-73.
1992: Lichter P; Walczak H; Weitz S; Behrmann I; Krammer P H
The human APO-1 (APT) antigen maps to 10q23, a region that is syntenic with mouse chromosome 19.
Genomics 1992;14(1):179-80.
1992: Falk M H; Trauth B C; Debatin K M; Klas C; Gregory C D; Rickinson A B; Calender A; Lenoir G M; Ellwart J W; Krammer P H
Expression of the APO-1 antigen in Burkitt lymphoma cell lines correlates with a shift towards a lymphoblastoid phenotype.
Blood 1992;79(12):3300-6.
1992: Li-Weber M; Eder A; Krafft-Czepa H; Krammer P H
T cell-specific negative regulation of transcription of the human cytokine IL-4.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(6):1913-8.
1992: Möller P; Henne C; Schmidt A; Eichelmann A; Leithäuser F; Brüderlein S; Dhein J; Krammer P H
[Expression of APO-1, a cell surface molecule mediating apoptosis, during normal B cell ontogeny and in B cell tumors. Co-expression and coregulation of APO-1 and ICAM-1 (CD54) in germinal central cells]
Verhandlungen der Deutschen Gesellschaft für Pathologie 1992;76():237-42.
1990: Echtenacher B; Falk W; Männel D N; Krammer P H
Requirement of endogenous tumor necrosis factor/cachectin for recovery from experimental peritonitis.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(11):3762-6.
1990: Köhler H R; Dhein J; Alberti G; Krammer P H
Ultrastructural analysis of apoptosis induced by the monoclonal antibody anti-APO-1 on a lymphoblastoid B cell line.
Ultrastructural pathology 1990;14(6):513-8.
1989: Trauth B C; Klas C; Peters A M; Matzku S; Möller P; Falk W; Debatin K M; Krammer P H
Monoclonal antibody-mediated tumor regression by induction of apoptosis.
Science (New York, N.Y.) 1989;245(4915):301-5.
1989: Falk W; Männel D N; Darjes H; Krammer P H
IL-1 induces high affinity IL-2 receptor expression of CD4-8- thymocytes.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(2):513-7.
1989: Von Hoegen I; Falk W; Kojouharoff G; Krammer P H
Internalization of interleukin 1 (IL 1) correlates with IL 1-induced IL 2 receptor expression and IL 2 secretion of EL4 thymoma cells.
European journal of immunology 1989;19(2):329-34.
1988: Esparza I; Ruppel A; Mestan J; Krammer P H
Preactivation of macrophages in mice acutely infected with Schistosoma mansoni.
Immunobiology 1988;177(2):105-19.
1988: Eder A; Krafft-Czepa H; Krammer P H
The 5' region of the human interleukin 4 gene: structure and potential regulatory elements.
Nucleic acids research 1988;16(2):772.
1987: Echtenacher B; Hederer R; Krammer P H
Biological effects of a rat monoclonal anti-mouse IFN-gamma antibody produced by in vitro immunization.
Immunobiology 1987;176(1-2):96-107.
1984: Gemsa D; Kubelka C; Debatin K M; Krammer P H
Activation of macrophages by lymphokines from T-cell clones: evidence for different macrophage-activating factors.
Molecular immunology 1984;21(12):1267-76.
1984: Kees U; Kaltmann B; Marcucci F; Hültner L; Staber F; Krammer P H
Frequency and activity of immune interferon (IFN-gamma)- and colony-stimulating factor-producing human peripheral blood T lymphocytes.
European journal of immunology 1984;14(4):368-73.
1984: Krammer P H; Gemsa D; Hamann U; Kaltmann B; Kubelka C; Müller W
Heterogeneity of macrophage-activating factors (MAFs) and their effects in vivo.
Symposium on Fundamental Cancer Research 1984;37():193-7.
1984: Krammer P H; Hamann U; Hültner L; Kaltmann B; Kees U; Kubelka C; Gemsa D
The activity of lymphokines secreted by normal and malignant T cells.
Springer seminars in immunopathology 1984;7(4):291-8.
1983: Gemsa D; Debatin K M; Kramer W; Kubelka C; Deimann W; Kees U; Krammer P H
Macrophage-activating factors from different T cell clones induce distinct macrophage functions.
Journal of immunology (Baltimore, Md. : 1950) 1983;131(2):833-44.
1983: Krammer P H; Echtenacher B; Gemsa D; Hamann U; Hültner L; Kaltmann B; Kees U; Kubelka C; Marcucci F
Immune-interferon (IFN-gamma), macrophage-activating factors (MAFs), and colony-stimulating factors (CSFs) secreted by T cell clones in limiting dilution microcultures, long-term cultures, and by T cell hybridomas.
Immunological reviews 1983;76():5-28.
1982: Staber F G; Hültner L; Marcucci F; Krammer P H
Production of colony-stimulating factors by murine T cells in limiting dilution and long-term cultures.
Nature 1982;298(5869):79-82.

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