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David Kranz

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Boris Engels; David M Kranz; Rebecca B Liu; Stephen C Meredith; Donald A Rowley; David C Binder; Victor H Engelhard; Alessandro Sette; John Sidney; Hans Schreiber
Relapse or eradication of cancer is predicted by Peptide-major histocompatibility complex affinity.
Jennifer N Lynch; K Scott Weber; David L Donermeyer; David M Kranz; Paul M Allen
Subtle changes in TCRα CDR1 profoundly increase the sensitivity of CD4 T cells.
D M Mattis; P M Schlievert; A R Spaulding; Eric Sundberg; O N Chuang-Smith; David M Kranz
Engineering a soluble high-affinity receptor domain that neutralizes staphylococcal enterotoxin C in rabbit models of disease.

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2013: Boris Engels; David M Kranz; Rebecca B Liu; Stephen C Meredith; Donald A Rowley; David C Binder; Victor H Engelhard; Alessandro Sette; John Sidney; Hans Schreiber
Relapse or eradication of cancer is predicted by Peptide-major histocompatibility complex affinity.
Cancer cell 2013;23(4):516-26.
2013: Jennifer N Lynch; K Scott Weber; David L Donermeyer; David M Kranz; Paul M Allen
Subtle changes in TCRα CDR1 profoundly increase the sensitivity of CD4 T cells.
Molecular immunology 2013;53(3):283-94.
2013: D M Mattis; P M Schlievert; A R Spaulding; Eric Sundberg; O N Chuang-Smith; David M Kranz
Engineering a soluble high-affinity receptor domain that neutralizes staphylococcal enterotoxin C in rabbit models of disease.
Protein engineering, design & selection : PEDS 2013;26(2):133-42.
2013: Carolina M Soto; Jennifer D Stone; Adam S Chervin; Boris Engels; Edward J Roy; Hans Schreiber; David M Kranz
MHC-class I-restricted CD4 T cells: a nanomolar affinity TCR has improved anti-tumor efficacy in vivo compared to the micromolar wild-type TCR.
Cancer immunology, immunotherapy : CII 2013;62(2):359-69.
2012: Jennifer D Stone; Hans Schreiber; Adam S Chervin; David M Kranz
Design and characterization of a protein superagonist of IL-15 fused with IL-15Rα and a high-affinity T cell receptor.
Biotechnology progress 2012;28(6):1588-97.
2012: D H Aggen; B M Baker; A S Chervin; Boris Engels; Philip D Greenberg; K H Piepenbrink; S A Richman; T M Schmitt; H Schreiber; J D Stone; David M Kranz
Single-chain VαVβ T-cell receptors function without mispairing with endogenous TCR chains.
Gene therapy 2012;19(4):365-74.
2012: Boris Engels; David M Kranz; Andrea J Sant; Adam S Chervin; Hans Schreiber
Long-term persistence of CD4(+) but rapid disappearance of CD8(+) T cells expressing an MHC class I-restricted TCR of nanomolar affinity.
Molecular therapy : the journal of the American Society of Gene Therapy 2012;20(3):652-60.
2012: Jianrong L Low; Anneta Naidoo; Susana G Shochat; Yin Hoe Yau; Gladys Yeo; Antonio Bertoletti; Adam J Gehring; Zi Zong Ho; David M Kranz; Gijsbert M Grotenbreg
Binding of TCR multimers and a TCR-like antibody with distinct fine-specificities is dependent on the surface density of HLA complexes.
PloS one 2012;7(12):e51397.
2012: Petra L Kohler; Malak Kotb; David M Kranz; Suba Nookala; Seth D Greenwood; Patrick M Schlievert
Staphylococcus aureus isolates encode variant staphylococcal enterotoxin B proteins that are diverse in superantigenicity and lethality.
PloS one 2012;7(7):e41157.
2012: Jennifer D Stone; Adam S Chervin; David H Aggen; David M Kranz
T cell receptor engineering.
Methods in enzymology 2012;503():189-222.
2011: Jennifer D Stone; Herman N Eisen; Maxim N Artyomov; Arup K Chakraborty; Adam S Chervin; David M Kranz
Interaction of streptavidin-based peptide-MHC oligomers (tetramers) with cell-surface TCRs.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(12):6281-90.
2011: Jarrett J Adams; Michael E Birnbaum; Wei Chen; Cheng Zhu; David M Kranz; Natalie A Bowerman; Baoyu Liu; Janet M Connolly; Samanthi Narayanan; Aron M Levin; Andrew C Kruse; K Christopher Garcia
T cell receptor signaling is limited by docking geometry to peptide-major histocompatibility complex.
Immunity 2011;35(5):681-93.
2011: Diana L Thomas; Vesna Tosic; Rosalinda Doty; David M Kranz; Jia Liu; Amy L MacNeill; Grant McFadden; Edward J Roy
Myxoma virus combined with rapamycin treatment enhances adoptive T cell therapy for murine melanoma brain tumors.
Cancer immunology, immunotherapy : CII 2011;60(10):1461-72.
2011: Mercedes B Fuertes; Aalok K Kacha; Justin Kline; David M Kranz; Kenneth M Murphy; Seng-Ryong Woo; Thomas F Gajewski
Host type I IFN signals are required for antitumor CD8+ T cell responses through CD8{alpha}+ dendritic cells.
The Journal of experimental medicine 2011;208(10):2005-16.
2011: Daniel A Bonsor; Rebecca A Buonpane; David M Kranz; Brian G Pierce; Sandra Postel; Ningyan Wang; Zhiping Weng; Penny Zhu; Eric Sundberg
Molecular basis of a million-fold affinity maturation process in a protein-protein interaction.
Journal of molecular biology 2011;411(2):321-8.
2011: Jennifer D Stone; David H Aggen; Adam S Chervin; Samanthi Narayanan; Thomas M Schmitt; Philip D Greenberg; David M Kranz
Opposite effects of endogenous peptide-MHC class I on T cell activity in the presence and absence of CD8.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(9):5193-200.
2011: David H Aggen; Adam S Chervin; Francis K Insaidoo; Kurt H Piepenbrink; Brian M Baker; David M Kranz
Identification and engineering of human variable regions that allow expression of stable single-chain T cell receptors.
Protein engineering, design & selection : PEDS 2011;24(4):361-72.
2010: Kristi L Strandberg; Jessica H Rotschafer; Sara M Vetter; Rebecca A Buonpane; David M Kranz; Patrick M Schlievert
Staphylococcal superantigens cause lethal pulmonary disease in rabbits.
The Journal of infectious diseases 2010;202(11):1690-7.
2010: Sangwoo Cho; Chittoor P Swaminathan; Daniel A Bonsor; Melissa C Kerzic; Rongjin Guan; Jianying Yang; Michele C Kieke; Peter S Andersen; David M Kranz; Roy A Mariuzza; Eric Sundberg
Assessing energetic contributions to binding from a disordered region in a protein-protein interaction .
Biochemistry 2010;49(43):9256-68.
2010: Ningyan Wang; Daiva M Mattis; Eric Sundberg; Patrick M Schlievert; David M Kranz
A single, engineered protein therapeutic agent neutralizes exotoxins from both Staphylococcus aureus and Streptococcus pyogenes.
Clinical and vaccine immunology : CVI 2010;17(11):1781-9.
2010: Stephen P Persaud; David L Donermeyer; K Scott Weber; David M Kranz; Paul M Allen
High-affinity T cell receptor differentiates cognate peptide-MHC and altered peptide ligands with distinct kinetics and thermodynamics.
Molecular immunology 2010;47(9):1793-801.
2010: Jennifer D Stone; David M Kranz
T cells use rafts for survival.
Immunity 2010;32(2):145-7.
2009: Adam S Chervin; Jennifer D Stone; Natalie A Bowerman; David M Kranz
Cutting edge: inhibitory effects of CD4 and CD8 on T cell activation induced by high-affinity noncognate ligands.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(12):7639-43.
2009: Chandy C John; Micah Niermann; Bazak Sharon; Marnie L Peterson; David M Kranz; Patrick M Schlievert
Staphylococcal toxic shock syndrome erythroderma is associated with superantigenicity and hypersensitivity.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2009;49(12):1893-6.
2009: Natalie A Bowerman; Leremy Colf; K Christopher Garcia; David M Kranz
Different strategies adopted by K(b) and L(d) to generate T cell specificity directed against their respective bound peptides.
The Journal of biological chemistry 2009;284(47):32551-61.
2009: Natalie A Bowerman; Terence S Crofts; Lukasz Chlewicki; Priscilla Do; Brian M Baker; K Christopher Garcia; David M Kranz
Engineering the binding properties of the T cell receptor:peptide:MHC ternary complex that governs T cell activity.
Molecular immunology 2009;46(15):3000-8.
2009: Edward J Roy; Mayandi Sivaguru; Glenn Fried; Brian D Gray; David M Kranz
Imaging membrane intercalating near infrared dyes to track multiple cell populations.
Journal of immunological methods 2009;348(1-2):18-29.
2009: Diana L Thomas; Miri Kim; Natalie A Bowerman; Samanthi Narayanan; David M Kranz; Hans Schreiber; Edward J Roy
Recurrence of intracranial tumors following adoptive T cell therapy can be prevented by direct and indirect killing aided by high levels of tumor antigen cross-presented on stromal cells.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(3):1828-37.
2009: Adam S Chervin; Jennifer D Stone; Phillip D Holler; Ailin Bai; Jianzhu Chen; Herman N Eisen; David M Kranz
The impact of TCR-binding properties and antigen presentation format on T cell responsiveness.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(2):1166-78.
2009: Jennifer D Stone; Adam S Chervin; David M Kranz
T-cell receptor binding affinities and kinetics: impact on T-cell activity and specificity.
Immunology 2009;126(2):165-76.
2009: Sarah A Richman; David H Aggen; Michelle L Dossett; David L Donermeyer; Paul M Allen; Philip D Greenberg; David M Kranz
Structural features of T cell receptor variable regions that enhance domain stability and enable expression as single-chain ValphaVbeta fragments.
Molecular immunology 2009;46(5):902-16.
2009: David M Kranz
Two mechanisms that account for major histocompatibility complex restriction of T cells.
F1000 biology reports 2009;1():55.
2009: Sarah A Richman; David M Kranz; Jennifer D Stone
Biosensor detection systems: engineering stable, high-affinity bioreceptors by yeast surface display.
Methods in molecular biology (Clifton, N.J.) 2009;504():323-50.
2008: Adam S Chervin; David H Aggen; John M Raseman; David M Kranz
Engineering higher affinity T cell receptors using a T cell display system.
Journal of immunological methods 2008;339(2):175-84.
2008: Lindsay L Jones; Leremy Colf; Alexander J Bankovich; Jennifer D Stone; Yi-Gui Gao; Choi Mui Chan; Raven H Huang; K Christopher Garcia; David M Kranz
Different thermodynamic binding mechanisms and peptide fine specificities associated with a panel of structurally similar high-affinity T cell receptors.
Biochemistry 2008;47(47):12398-408.
2008: Lindsay L Jones; Leremy Colf; Jennifer D Stone; K Christopher Garcia; David M Kranz
Distinct CDR3 conformations in TCRs determine the level of cross-reactivity for diverse antigens, but not the docking orientation.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(9):6255-64.
2008: Diana L Thomas; David M Kranz; Edward J Roy
Experimental manipulations of afferent immune responses influence efferent immune responses to brain tumors.
Cancer immunology, immunotherapy : CII 2008;57(9):1323-33.
2008: Xi Yang; Rebecca A Buonpane; Beenu Moza; A K M Nur-ur Rahman; Ningyan Wang; Patrick M Schlievert; John K McCormick; Eric Sundberg; David M Kranz
Neutralization of multiple staphylococcal superantigens by a single-chain protein consisting of affinity-matured, variable domain repeats.
The Journal of infectious diseases 2008;198(3):344-8.
2008: Timothy M Fan; David M Kranz; Richard A Flavell; Edward J Roy
Costimulatory strength influences the differential effects of transforming growth factor beta1 for the generation of CD8+ regulatory T cells.
Molecular immunology 2008;45(10):2937-50.
2008: Bin Zhang; Yi Zhang; Natalie A Bowerman; Andrea Schietinger; Yang-Xin Fu; David M Kranz; Donald A Rowley; Hans Schreiber
Equilibrium between host and cancer caused by effector T cells killing tumor stroma.
Cancer research 2008;68(5):1563-71.
2007: Sarah A Richman; David M Kranz
Display, engineering, and applications of antigen-specific T cell receptors.
Biomolecular engineering 2007;24(4):361-73.
2007: test testing; Alexander J Bankovich; Corey W Liu; Leremy Colf; Lindsay L Jones; David M Kranz; Joseph D Puglisi; K Christopher Garcia
Solution mapping of T cell receptor docking footprints on peptide-MHC.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(32):13080-5.
2007: Timothy M Fan; David M Kranz; Edward J Roy
Enhancing antitumor immunity: combining IL-12 with TGFbeta1 antagonism.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2007;30(5):479-89.
2007: Rebecca A Buonpane; Hywyn R O Churchill; Beenu Moza; Eric Sundberg; Marnie L Peterson; Patrick M Schlievert; David M Kranz
Neutralization of staphylococcal enterotoxin B by soluble, high-affinity receptor antagonists.
Nature medicine 2007;13(6):725-9.
2007: Steven M Truscott; Lonnie Lybarger; John M Martinko; Vesselin Mitaksov; David M Kranz; Janet M Connolly; daved fremont; Ted H Hansen
Disulfide bond engineering to trap peptides in the MHC class I binding groove.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(10):6280-9.
2007: Leremy Colf; Alexander J Bankovich; Nicole A Hanick; Natalie A Bowerman; Lindsay L Jones; David M Kranz; K Christopher Garcia
How a single T cell receptor recognizes both self and foreign MHC.
Cell 2007;129(1):135-46.
2007: Susan E Brophy; Lindsay L Jones; Phillip D Holler; David M Kranz
Cellular uptake followed by class I MHC presentation of some exogenous peptides contributes to T cell stimulatory capacity.
Molecular immunology 2007;44(9):2184-94.
2007: Beenu Moza; Ashok K Varma; Rebecca A Buonpane; Penny Zhu; Christine A Herfst; Melissa Call; Anne-Kathrin Wilbuer; Nilufer P Seth; Kai W Wucherpfennig; John K McCormick; David M Kranz; Eric Sundberg
Structural basis of T-cell specificity and activation by the bacterial superantigen TSST-1.
The EMBO journal 2007;26(4):1187-97.
2007: Limin Wang; Yiwei Zhao; Zhong Li; Yi Guo; Lindsay L Jones; David M Kranz; Walid Mourad; Hongmin Li
Crystal structure of a complete ternary complex of TCR, superantigen and peptide-MHC.
Nature structural & molecular biology 2007;14(2):169-71.
2007: Bin Zhang; Natalie A Bowerman; Joseph K Salama; Hank Schmidt; Michael T Spiotto; Andrea Schietinger; Ping Yu; Yang-Xin Fu; Ralph R Weichselbaum; Donald A Rowley; David M Kranz; Hans Schreiber
Induced sensitization of tumor stroma leads to eradication of established cancer by T cells.
The Journal of experimental medicine 2007;204(1):49-55.
2006: David L Donermeyer; K Scott Weber; David M Kranz; Paul M Allen
The study of high-affinity TCRs reveals duality in T cell recognition of antigen: specificity and degeneracy.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(10):6911-9.
2006: Lindsay L Jones; Susan E Brophy; Alexander J Bankovich; Leremy Colf; Nicole A Hanick; K Christopher Garcia; David M Kranz
Engineering and characterization of a stabilized alpha1/alpha2 module of the class I major histocompatibility complex product Ld.
The Journal of biological chemistry 2006;281(35):25734-44.
2006: Beenu Moza; Rebecca A Buonpane; Penny Zhu; Christine A Herfst; A K M Nur-ur Rahman; John K McCormick; David M Kranz; Eric Sundberg
Long-range cooperative binding effects in a T cell receptor variable domain.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(26):9867-72.
2006: S A Richman; S J Healan; K Scott Weber; David L Donermeyer; Michelle L Dossett; P D Greenberg; Paul M Allen; David M Kranz
Development of a novel strategy for engineering high-affinity proteins by yeast display.
Protein engineering, design & selection : PEDS 2006;19(6):255-64.
2006: Xinguo Jiang; Brent A Orr; David M Kranz; David J Shapiro
Estrogen induction of the granzyme B inhibitor, proteinase inhibitor 9, protects cells against apoptosis mediated by cytotoxic T lymphocytes and natural killer cells.
Endocrinology 2006;147(3):1419-26.
2005: K Scott Weber; David L Donermeyer; Paul M Allen; David M Kranz
Class II-restricted T cell receptor engineered in vitro for higher affinity retains peptide specificity and function.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(52):19033-8.
2005: Sangwoo Cho; Chittoor P Swaminathan; Jianying Yang; Melissa C Kerzic; Rongjin Guan; Michele C Kieke; David M Kranz; Roy A Mariuzza; Eric Sundberg
Structural basis of affinity maturation and intramolecular cooperativity in a protein-protein interaction.
Structure (London, England : 1993) 2005;13(12):1775-87.
2005: Rebecca A Buonpane; Beenu Moza; Eric Sundberg; David M Kranz
Characterization of T cell receptors engineered for high affinity against toxic shock syndrome toxin-1.
Journal of molecular biology 2005;353(2):308-21.
2005: Edward J Roy; Osamu Takikawa; David M Kranz; Alicia Brown; Diana L Thomas
Neuronal localization of indoleamine 2,3-dioxygenase in mice.
Neuroscience letters 2005;387(2):95-9.
2005: Lukasz K Chlewicki; Phillip D Holler; Bridget C Monti; Matthew R Clutter; David M Kranz
High-affinity, peptide-specific T cell receptors can be generated by mutations in CDR1, CDR2 or CDR3.
Journal of molecular biology 2005;346(1):223-39.
2005: David M Kranz
T cell receptor CDRs: starring versus supporting roles.
Nature immunology 2005;6(2):130-2.
2004: Ute Gawlick; David M Kranz; Victor D Schepkin; Edward J Roy
A conjugate of a tumor-targeting ligand and a T cell costimulatory antibody to treat brain tumors.
Bioconjugate chemistry 2004;15(5):1137-45.
2004: Kah-Whye Peng; Phillip D Holler; B A Orr; David M Kranz; stephen russell
Targeting virus entry and membrane fusion through specific peptide/MHC complexes using a high-affinity T-cell receptor.
Gene therapy 2004;11(15):1234-9.
2004: Edward J Roy; Ute Gawlick; Brent A Orr; David M Kranz
Folate-mediated targeting of T cells to tumors.
Advanced drug delivery reviews 2004;56(8):1219-31.
2004: Matthew E Roth; Li Feng; Kevin J McConnell; Paul J Schaffer; Cesar E Guerra; Jason P Affourtit; Kevin R Piper; Lorri Guccione; Jayashree Hariharan; Maura J Ford; Stephen W Powell; Harish Krishnaswamy; Jennifer Lane; Lisa Guccione; Gino Intrieri; Jane S Merkel; Clotilde Perbost; Anthony Valerio; Brenda Zolla; Carol D Graham; Jonathan Hnath; Chris Michaelson; Rixin Wang; Baoge Ying; Conrad Halling; Craig E Parman; Debasish Raha; Brent Orr; Barbara Jedrzkiewicz; Ji Liao; Anton Tevelev; Martin J Mattessich; David M Kranz; Michelle Lacey; Joseph C Kaufman; Junhyong Kim; Darin Latimer; Paul M Lizardi
Expression profiling using a hexamer-based universal microarray.
Nature biotechnology 2004;22(4):418-26.
2004: Phillip D Holler; David M Kranz
T cell receptors: affinities, cross-reactivities, and a conformer model.
Molecular immunology 2004;40(14-15):1027-31.
2003: Jianying Yang; Chittoor P Swaminathan; Yuping Huang; Rongjin Guan; Sangwoo Cho; Michele C Kieke; David M Kranz; Roy A Mariuzza; Eric Sundberg
Dissecting cooperative and additive binding energetics in the affinity maturation pathway of a protein-protein interface.
The Journal of biological chemistry 2003;278(50):50412-21.
2003: Julie Dam; Rongjin Guan; Kannan Natarajan; Nazzareno Dimasi; Lukasz K Chlewicki; David M Kranz; Peter Schuck; David Margulies; Roy A Mariuzza
Variable MHC class I engagement by Ly49 natural killer cell receptors demonstrated by the crystal structure of Ly49C bound to H-2K(b).
Nature immunology 2003;4(12):1213-22.
2003: Jens A Leifert; Phillip D Holler; Stephanie Harkins; David M Kranz; J Lindsay Whitton
The cationic region from HIV tat enhances the cell-surface expression of epitope/MHC class I complexes.
Gene therapy 2003;10(25):2067-73.
2003: Jianzhu Chen; Herman N Eisen; David M Kranz
A model T-cell receptor system for studying memory T-cell development.
Microbes and infection / Institut Pasteur 2003;5(3):233-40.
2003: Brent A Orr; Lori M Carr; K Dane Wittrup; Edward J Roy; David M Kranz
Rapid method for measuring ScFv thermal stability by yeast surface display.
Biotechnology progress 2003;19(2):631-8.
2003: Scott E Starwalt; Emma L Masteller; Jeffrey A Bluestone; David M Kranz
Directed evolution of a single-chain class II MHC product by yeast display.
Protein engineering 2003;16(2):147-56.
2003: Phillip D Holler; David M Kranz
Quantitative analysis of the contribution of TCR/pepMHC affinity and CD8 to T cell activation.
Immunity 2003;18(2):255-64.
2003: Susan E Brophy; Phillip D Holler; David M Kranz
A yeast display system for engineering functional peptide-MHC complexes.
Journal of immunological methods 2003;272(1-2):235-46.
2003: Peter U Y Lee; David M Kranz
Allogeneic and syngeneic class I MHC complexes drive the association of CD8 and TCR on 2C T cells.
Molecular immunology 2003;39(12):687-95.
2003: Hywyn R O Churchill; David M Kranz
Analysis of superantigen binding to soluble T-cell receptors.
Methods in molecular biology (Clifton, N.J.) 2003;214():101-11.
2003: Hywyn R O Churchill; David M Kranz
Directed evolution of T-cell receptors for binding superantigens.
Methods in molecular biology (Clifton, N.J.) 2003;214():87-99.
2003: Phillip D Holler; Lukasz K Chlewicki; David M Kranz
TCRs with high affinity for foreign pMHC show self-reactivity.
Nature immunology 2003;4(1):55-62.
2001: Phillip D Holler; A R Lim; BK Cho; LA Rund; David M Kranz
CD8(-) T cell transfectants that express a high affinity T cell receptor exhibit enhanced peptide-dependent activation.
The Journal of experimental medicine 2001;194(8):1043-52.
2001: Michele C Kieke; Eric Sundberg; EV Shusta; Roy A Mariuzza; K Dane Wittrup; David M Kranz
High affinity T cell receptors from yeast display libraries block T cell activation by superantigens.
Journal of molecular biology 2001;307(5):1305-15.
2001: Bryan K Cho; K C Lian; P Lee; A Brunmark; C McKinley; Jianzhu Chen; David M Kranz; Herman N Eisen
Differences in antigen recognition and cytolytic activity of CD8(+) and CD8(-) T cells that express the same antigen-specific receptor.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(4):1723-7.
2001: MD Griffin; P O Holman; Q Tang; N Ashourian; U Korthäuer; David M Kranz; Jeffrey A Bluestone
Development and applications of surface-linked single chain antibodies against T-cell antigens.
Journal of immunological methods 2001;248(1-2):77-90.
2000: Edward J Roy; Ute Gawlick; Brent A Orr; LA Rund; A G Webb; David M Kranz
IL-12 treatment of endogenously arising murine brain tumors.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(12):7293-9.
2000: David M Kranz
Incompatible differences: view of an allogeneic pMHC-TCR complex.
Nature immunology 2000;1(4):277-8.
2000: EV Shusta; Phillip D Holler; Michele C Kieke; David M Kranz; K Dane Wittrup
Directed evolution of a stable scaffold for T-cell receptor engineering.
Nature biotechnology 2000;18(7):754-9.
2000: Phillip D Holler; P O Holman; EV Shusta; SM O'Herrin; K Dane Wittrup; David M Kranz
In vitro evolution of a T cell receptor with high affinity for peptide/MHC.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(10):5387-92.
2000: MD Griffin; D K Hong; P O Holman; Kyung-Mi Lee; M J Whitters; SM O'Herrin; Francesca Fallarino; M Collins; D M Segal; Thomas F Gajewski; David M Kranz; Jeffrey A Bluestone
Blockade of T cell activation using a surface-linked single-chain antibody to CTLA-4 (CD152).
Journal of immunology (Baltimore, Md. : 1950) 2000;164(9):4433-42.
2000: P U Lee; Hywyn R O Churchill; M Daniels; S C Jameson; David M Kranz
Role of 2CT cell receptor residues in the binding of self- and allo-major histocompatibility complexes.
The Journal of experimental medicine 2000;191(8):1355-64.
2000: Sanjay Kulkarni; P O Holman; A Kopelan; Gijs A van Seventer; Jean Maguire van Seventer; David M Kranz; E Steve Woodle
Programmed cell death signaling via cell-surface expression of a single-chain antibody transgene.
Transplantation 2000;69(6):1209-17.
2000: Hywyn R O Churchill; P S Andersen; EA Parke; Roy A Mariuzza; David M Kranz
Mapping the energy of superantigen Staphylococcus enterotoxin C3 recognition of an alpha/beta T cell receptor using alanine scanning mutagenesis.
The Journal of experimental medicine 2000;191(5):835-46.
1999: EV Shusta; Michele C Kieke; EA Parke; David M Kranz; K Dane Wittrup
Yeast polypeptide fusion surface display levels predict thermal stability and soluble secretion efficiency.
Journal of molecular biology 1999;292(5):949-56.
1999: LA Rund; BK Cho; TC Manning; Phillip D Holler; Edward J Roy; David M Kranz
Bispecific agents target endogenous murine T cells against human tumor xenografts.
International journal of cancer. Journal international du cancer 1999;83(1):141-9.
1999: T C Manning; David M Kranz
Binding energetics of T-cell receptors: correlation with immunological consequences.
Immunology today 1999;20(9):417-22.
1999: David W Pledger; T C Brodnicki; B L Graham; S Tetin; David M Kranz; Darwin S Linthicum
Construction and characterization of two anti-sweetener single chain antibodies using radioligand binding, fluorescence and circular dichroism spectroscopy.
Journal of molecular recognition : JMR 1999;12(4):258-66.
1999: Michele C Kieke; EV Shusta; Eric T Boder; Luc Teyton; K Dane Wittrup; David M Kranz
Selection of functional T cell receptor mutants from a yeast surface-display library.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(10):5651-6.
1999: Peter S Andersen; Pauline Lavoie; Rafick-Pierre Sékaly; Hywyn R O Churchill; David M Kranz; Patrick M Schlievert; Klaus Karjalainen; Roy A Mariuzza
Role of the T cell receptor alpha chain in stabilizing TCR-superantigen-MHC class II complexes.
Immunity 1999;10(4):473-83.
1999: T C Manning; EA Parke; Luc Teyton; David M Kranz
Effects of complementarity determining region mutations on the affinity of an alpha/beta T cell receptor: measuring the energy associated with CD4/CD8 repertoire skewing.
The Journal of experimental medicine 1999;189(3):461-70.
1998: TA Patrick; David M Kranz; J F Zachary; Edward J Roy
Intracerebral bispecific ligand-antibody conjugate increases survival of animals bearing endogenously arising brain tumors.
International journal of cancer. Journal international du cancer 1998;78(4):470-9.
1998: BK Cho; Michele C Kieke; Eric T Boder; K Dane Wittrup; David M Kranz
A yeast surface display system for the discovery of ligands that trigger cell activation.
Journal of immunological methods 1998;220(1-2):179-88.
1998: Sanjay Kulkarni; P Holman; David M Kranz; N Zhou; Jean Maguire van Seventer; E Steve Woodle
Construction of a single-chain antibody derived from 5H7, a monoclonal antibody specific for a death signaling domain of human class I major histocompatibility complex.
Transplantation proceedings 1998;30(4):1081.
1998: Edward J Roy; BK Cho; LA Rund; TA Patrick; David M Kranz
Targeting T cells against brain tumors with a bispecific ligand-antibody conjugate.
International journal of cancer. Journal international du cancer 1998;76(5):761-6.
1998: David M Kranz; TC Manning; LA Rund; BK Cho; M M Gruber; Edward J Roy
Targeting tumor cells with bispecific antibodies and T cells.
Journal of controlled release : official journal of the Controlled Release Society 1998;53(1-3):77-84.
1998: T C Manning; C J Schlueter; T C Brodnicki; EA Parke; Jeffrey A Speir; K Christopher Garcia; Luc Teyton; Ian A Wilson; David M Kranz
Alanine scanning mutagenesis of an alphabeta T cell receptor: mapping the energy of antigen recognition.
Immunity 1998;8(4):413-25.
1997: TC Manning; LA Rund; M M Gruber; Francesca Fallarino; T F Gajewski; David M Kranz
Antigen recognition and allogeneic tumor rejection in CD8+ TCR transgenic/RAG(-/-) mice.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(10):4665-75.
1997: Michele C Kieke; BK Cho; Eric T Boder; David M Kranz; K Dane Wittrup
Isolation of anti-T cell receptor scFv mutants by yeast surface display.
Protein engineering 1997;10(11):1303-10.
1997: BK Cho; Edward J Roy; TA Patrick; David M Kranz
Single-chain Fv/folate conjugates mediate efficient lysis of folate-receptor-positive tumor cells.
Bioconjugate chemistry 1997;8(3):338-46.
1997: TA Patrick; David M Kranz; Terry Van Dyke; Edward J Roy
Folate receptors as potential therapeutic targets in choroid plexus tumors of SV40 transgenic mice.
Journal of neuro-oncology 1997;32(2):111-23.
1996: C J Schlueter; T C Manning; B A Schodin; David M Kranz
A residue in the center of peptide QL9 affects binding to both Ld and the T cell receptor.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(10):4478-85.
1996: B A Schodin; T J Tsomides; David M Kranz
Correlation between the number of T cell receptors required for T cell activation and TCR-ligand affinity.
Immunity 1996;5(2):137-46.
1996: T C Manning; B A Schodin; David M Kranz
A strategy for the synthesis and screening of thiol-modified peptide variants recognized by T cells.
Journal of immunological methods 1996;192(1-2):125-32.
1996: B A Schodin; C J Schlueter; David M Kranz
Binding properties and solubility of single-chain T cell receptors expressed in E. coli.
Molecular immunology 1996;33(9):819-29.
1996: C J Schlueter; B A Schodin; S Y Tetin; David M Kranz
Specificity and binding properties of a single-chain T cell receptor.
Journal of molecular biology 1996;256(5):859-69.
1996: T C Brodnicki; P O Holman; David M Kranz
Reactivity and epitope mapping of single-chain T cell receptors with monoclonal antibodies.
Molecular immunology 1996;33(3):253-63.
1995: B K Cho; B A Schodin; David M Kranz
Characterization of a single-chain antibody to the beta-chain of the T cell receptor.
The Journal of biological chemistry 1995;270(43):25819-26.
1995: David M Kranz; M Gruber; E R Wilson
Properties of bispecific single chain antibodies expressed in Escherichia coli.
Journal of hematotherapy 1995;4(5):403-8.
1995: David M Kranz; TA Patrick; Kevin E Brigle; Michael J Spinella; Edward J Roy
Conjugates of folate and anti-T-cell-receptor antibodies specifically target folate-receptor-positive tumor cells for lysis.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(20):9057-61.
1994: B A Tjoa; David M Kranz
Sequence restrictions in T cell receptor beta-chains that have specificity for a self-peptide/Ld complex.
Molecular immunology 1994;31(10):705-11.
1994: M Gruber; B A Schodin; E R Wilson; David M Kranz
Efficient tumor cell lysis mediated by a bispecific single chain antibody expressed in Escherichia coli.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(11):5368-74.
1994: B A Tjoa; David M Kranz
Generation of cytotoxic T-lymphocytes to a self-peptide/class I complex: a model for peptide-mediated tumor rejection.
Cancer research 1994;54(1):204-8.
1993: B A Schodin; David M Kranz
Binding affinity and inhibitory properties of a single-chain anti-T cell receptor antibody.
The Journal of biological chemistry 1993;268(34):25722-7.
1993: P O Holman; M E Roth; M Huang; David M Kranz
Characterization of transcripts from unrearranged V alpha 8 genes in the thymus.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(4):1959-67.
1993: W S Hoo; David M Kranz
Role of CD8 in staphylococcal enterotoxin B-mediated lysis by cytotoxic T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(10):4331-7.
1992: M E Roth; B A Tjoa; C J Schlueter; E R Wilson; B C Lunn; David M Kranz
Sequence diversity of T cell receptor alpha chain transcripts from BALB/c thymus.
Molecular immunology 1992;29(12):1447-55.
1992: N A Johnson; J B Keeney; M Hedayat; K W Clary; David M Kranz; Ted H Hansen
T cell receptor rearrangements in various S49 lymphoma sublines.
Molecular immunology 1992;29(11):1325-35.
1992: B Tjoa; David M Kranz
Diversity of T cell receptor-alpha chain transcripts from hyperimmune alloreactive T cells.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(1):253-9.
1992: W F Hoo; M J Lacy; Lisa K Denzin; Edward W Voss; K D Hardman; David M Kranz
Characterization of a single-chain T-cell receptor expressed in Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(10):4759-63.
1992: P O Holman; M J Lacy; M E Roth; David M Kranz
Mechanisms that generate junctional diversity in alpha and delta chains that use the Tcrd-V3 gene product.
Immunogenetics 1992;35(1):33-40.
1991: M E Roth; P O Holman; David M Kranz
Nonrandom use of J alpha gene segments. Influence of V alpha and J alpha gene location.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(3):1075-81.
1989: M E Roth; M J Lacy; Leslie Klis McNeil; David M Kranz
Correction: selection of variable-joining region combinations in the T cell receptor.
Science (New York, N.Y.) 1989;245(4922):1032.
1989: M E Roth; M J Lacy; Leslie Klis McNeil; David M Kranz
Analysis of T cell receptor transcripts using the polymerase chain reaction.
BioTechniques 1989;7(7):746-54.
1989: M J Lacy; Leslie Klis McNeil; M E Roth; David M Kranz
T-cell receptor delta-chain diversity in peripheral lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(3):1023-6.
1989: D Y Loh; W C Sha; C A Nelson; R D Newberry; David M Kranz; John H Russell
Positive and negative selection of T lymphocytes.
Cold Spring Harbor symposia on quantitative biology 1989;54 Pt 1():147-51.
1988: W C Sha; C A Nelson; R D Newberry; David M Kranz; John H Russell; D Y Loh
Positive and negative selection of an antigen receptor on T cells in transgenic mice.
Nature 1988;336(6194):73-6.
1988: W C Sha; C A Nelson; R D Newberry; David M Kranz; John H Russell; D Y Loh
Selective expression of an antigen receptor on CD8-bearing T lymphocytes in transgenic mice.
Nature 1988;335(6187):271-4.
1988: M E Roth; M J Lacy; Leslie Klis McNeil; David M Kranz
Selection of variable-joining region combinations in the alpha chain of the T cell receptor.
Science (New York, N.Y.) 1988;241(4871):1354-8.
1988: A L Gibson; J N Herron; X M He; V A Patrick; M L Mason; J N Lin; David M Kranz; E W Voss; Allen B Edmundson
Differences in crystal properties and ligand affinities of an antifluorescyl Fab (4-4-20) in two solvent systems.
Proteins 1988;3(3):155-60.
1987: C R Verret; A A Firmenich; David M Kranz; Herman N Eisen
Resistance of cytotoxic T lymphocytes to the lytic effects of their toxic granules.
The Journal of experimental medicine 1987;166(5):1536-47.
1987: David M Kranz; H N Eisen
Resistance of cytotoxic T lymphocytes to lysis by a clone of cytotoxic T lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(10):3375-9.
1987: Herman N Eisen; C R Verret; A A Firmenich; David M Kranz
Resistance of cytolytic T lymphocytes to the lytic components they release.
Annales de l'Institut Pasteur. Immunology 1987;138(2):328-31.
1987: David M Kranz; M S Pasternack; H N Eisen
Recognition and lysis of target cells by cytotoxic T lymphocytes.
Federation proceedings 1987;46(2):309-12.
1986: J Lieberman; C R Verret; David M Kranz; S C Hubbard; H Saito; D H Raulet; Susumu Tonegawa; Herman N Eisen
A phosphorylated, disulfide-linked membrane protein in murine cytotoxic T lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(20):7870-4.
1986: J N Herron; David M Kranz; David Jameson; E W Voss
Thermodynamic properties of ligand binding by monoclonal anti-fluorescyl antibodies.
Biochemistry 1986;25(16):4602-9.
1986: E B Reilly; David M Kranz; Susumu Tonegawa; H N Eisen
A functional gamma gene formed from known gamma-gene segments is not necessary for antigen-specific responses of murine cytotoxic T lymphocytes.
Nature 1986;321(6073):878-80.
1986: S C Hubbard; David M Kranz; G D Longmore; M V Sitkovsky; Herman N Eisen
Glycosylation of the T-cell antigen-specific receptor and its potential role in lectin-mediated cytotoxicity.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(6):1852-6.
1986: J Novotný; Susumu Tonegawa; H Saito; David M Kranz; H N Eisen
Secondary, tertiary, and quaternary structure of T-cell-specific immunoglobulin-like polypeptide chains.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(3):742-6.
1985: M A Liu; David M Kranz; James T Kurnick; LA Boyle; Ronald Levy; H N Eisen
Heteroantibody duplexes target cells for lysis by cytotoxic T lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(24):8648-52.
1985: H N Eisen; M A Liu; David M Kranz
The central role of the antigen-specific receptor complex in triggering cytolytic activity of cytotoxic T lymphocytes.
Bioscience reports 1985;5(10-11):885-92.
1985: J S Heilig; L H Glimcher; David M Kranz; Linda K Clayton; J L Greenstein; H Saito; A M Maxam; S J Burakoff; H N Eisen; Susumu Tonegawa
Expression of the T-cell-specific gamma gene is unnecessary in T cells recognizing class II MHC determinants.
Nature 1985;317(6032):68-70.
1985: David M Kranz; H Saito; M Heller; Yohtaroh Takagaki; W Haas; H N Eisen; Susumu Tonegawa
Limited diversity of the rearranged T-cell gamma gene.
Nature 1985;313(6005):752-5.
1985: David M Kranz; H Saito; C M Disteche; K Swisshelm; D Pravtcheva; F H Ruddle; H N Eisen; Susumu Tonegawa
Chromosomal locations of the murine T-cell receptor alpha-chain gene and the T-cell gamma gene.
Science (New York, N.Y.) 1985;227(4689):941-5.
1985: A C Hayday; H Saito; S D Gillies; David M Kranz; G Tanigawa; H N Eisen; Susumu Tonegawa
Structure, organization, and somatic rearrangement of T cell gamma genes.
Cell 1985;40(2):259-69.
1984: David M Kranz; Susumu Tonegawa; H N Eisen
Attachment of an anti-receptor antibody to non-target cells renders them susceptible to lysis by a clone of cytotoxic T lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(24):7922-6.
1984: D H Sherman; David M Kranz; Herman N Eisen
Expression of structurally diverse Qa-2-encoded molecules on the surface of cloned cytotoxic T lymphocytes.
The Journal of experimental medicine 1984;160(5):1421-30.
1984: H Saito; David M Kranz; Yohtaroh Takagaki; A C Hayday; H N Eisen; Susumu Tonegawa
A third rearranged and expressed gene in a clone of cytotoxic T lymphocytes.
Nature 1984;312(5989):36-40.
1984: H Saito; David M Kranz; Yohtaroh Takagaki; A C Hayday; H N Eisen; Susumu Tonegawa
Complete primary structure of a heterodimeric T-cell receptor deduced from cDNA sequences.
Nature 1984;309(5971):757-62.
1984: David M Kranz; D H Sherman; M V Sitkovsky; M S Pasternack; Herman N Eisen
Immunoprecipitation of cell surface structures of cloned cytotoxic T lymphocytes by clone-specific antisera.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(2):573-7.
1983: David M Kranz; D W Ballard; E W Voss
Expression of defined idiotypes throughout the BALB/c anti-fluorescyl antibody response: affinity and idiotype analyses of heterogeneous antibodies.
Molecular immunology 1983;20(12):1313-22.
1983: David M Kranz; E W Voss
Idiotypic analysis of monoclonal anti-fluorescyl antibodies: localization and characterization of idiotypic determinants.
Molecular immunology 1983;20(12):1301-12.
1983: D W Ballard; David M Kranz; E W Voss
Monoclonal IgM antibody exhibiting high-affinity binding and cryoglobulin properties.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(16):5071-4.
1982: David M Kranz; J N Herron; E W Voss
Mechanisms of ligand binding by monoclonal anti-fluorescyl antibodies.
The Journal of biological chemistry 1982;257(12):6987-95.
1982: M R Jarvis; Gerald Casperson; David M Kranz; E W Voss
Affinity maturation of NZB and BALB/cV mice anti-fluorescyl response.
Molecular immunology 1982;19(4):525-33.
1981: David M Kranz; E W Voss
Partial elucidation of an anti-hapten repertoire in BALB/c mice: comparative characterization of several monoclonal anti-fluorescyl antibodies.
Molecular immunology 1981;18(10):889-98.
1981: David M Kranz; E W Voss
Restricted reassociation of heavy and light chains from hapten-specific monoclonal antibodies.
Proceedings of the National Academy of Sciences of the United States of America 1981;78(9):5807-11.
1981: David M Kranz; J N Herron; D E Giannis; E W Voss
Kinetics and mechanism of deuterium oxide-induced fluorescence enhancement of fluorescyl ligand bound to specific heterogeneous and homogeneous antibodies.
The Journal of biological chemistry 1981;256(9):4433-8.
1980: David M Kranz; P A Billing; J N Herron; E W Voss
Modified hybridoma methodology: antigen-directed chemically mediated cell fusion.
Immunological communications 1980;9(7):639-51.
1977: J C Tsang; David M Kranz; D A Brown
The effect of polymyxin B on outer membrane of Serratia marcescens: activation and dissociation of outer membrane associated alkaline phosphatase.
The Journal of antibiotics 1977;30(3):270-1.
1976: David M Kranz; J C Tsang
Effect of saline on the releasability of alkaline phosphatase from cells of Serratia marcescens.
Microbios 1976;15(61-62):165-75.