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Matthew Krasowski

Research Profile

Chemicals & Drugs

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Publications

TOP 3
Brian R Jackson; Matthew D Krasowski; Peter J Sims
Laboratory diagnostic oversight committees and the profession of laboratory medicine.
Andrew M King; Matthew D Krasowski; Michael J Lynch; Nathan B Menke; Jennifer L Pugh; Anthony F Pizon
Nonfatal tramadol overdose may cause false-positive phencyclidine on Emit-II assay.
Lee R Hagey; Matthew D Krasowski
Microbial biotransformations of bile acids as detected by electrospray mass spectrometry.

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All Publications

2013: Brian R Jackson; Matthew D Krasowski; Peter J Sims
Laboratory diagnostic oversight committees and the profession of laboratory medicine.
American journal of clinical pathology 2013;139(3):273-4.
2013: Andrew M King; Matthew D Krasowski; Michael J Lynch; Nathan B Menke; Jennifer L Pugh; Anthony F Pizon
Nonfatal tramadol overdose may cause false-positive phencyclidine on Emit-II assay.
The American journal of emergency medicine 2013;31(2):444.e5-9.
2013: Lee R Hagey; Matthew D Krasowski
Microbial biotransformations of bile acids as detected by electrospray mass spectrometry.
Advances in nutrition (Bethesda, Md.) 2013;4(1):29-35.
2012: Michelle Kurt-Mangold; Denny Drees; Matthew D Krasowski
Extremely high myoglobin plasma concentrations producing hook effect in a critically ill patient.
Clinica chimica acta; international journal of clinical chemistry 2012;414():179-81.
2012: Vilte E Barakauskas; Rebecka Davis; Matthew D Krasowski; Gwendolyn A McMillin
Unresolved discrepancies between cannabinoid test results for infant urine.
Clinical chemistry 2012;58(9):1364-7.
2012: Andrew E Fidler; Patrick T Holland; Sean Ekins; Erica J Reschly; Matthew D Krasowski
Activation of a tunicate (Ciona intestinalis) xenobiotic receptor orthologue by both natural toxins and synthetic toxicants.
Toxicon : official journal of the International Society on Toxinology 2012;59(2):365-72.
2012: Sandhya Kortagere; Matthew D Krasowski; Sean Ekins
Ligand- and structure-based pregnane X receptor models.
Methods in molecular biology (Clifton, N.J.) 2012;929():359-75.
2012: Carolyn D Rysgaard; Jeff Kulhavy; Cory S Morris; Tami Bebber; Scott R Davis; Denny Drees; Matthew D Krasowski
Positive hepatitis B surface antigen tests due to recent vaccination: a persistent problem.
BMC clinical pathology 2012;12():15.
2012: Matthew D Krasowski; Louis E Penrod
Clinical decision support of therapeutic drug monitoring of phenytoin: measured versus adjusted phenytoin plasma concentrations.
BMC medical informatics and decision making 2012;12():7.
2012: Matthew D Krasowski; Rebecca M Wilcoxon; Joel Miron
A retrospective analysis of glycol and toxic alcohol ingestion: utility of anion and osmolal gaps.
BMC clinical pathology 2012;12():1.
2011: Matthew D Krasowski; Anton J Hopfinger
The discovery of new anesthetics by targeting GABA(A) receptors.
Expert opinion on drug discovery 2011;6(11):1187-201.
2011: Katsuhisa Kurogi; Elisha Injeti; Matthew D Krasowski; Ming-Yih Liu; Yoichi Sakakibara; Masahito Suiko; Frederick E Williams; Ming-Cheh Liu
A comparative study of the sulfation of bile acids and a bile alcohol by the Zebra danio (Danio rerio) and human cytosolic sulfotransferases (SULTs).
The Journal of steroid biochemistry and molecular biology 2011;127(3-5):307-14.
2011: Matthew D Krasowski
Pathology consultation on vitamin D testing.
American journal of clinical pathology 2011;136(4):507-14.
2011: Shoujiro Ogawa; lee hagey; Alan F Hofmann; Shigeo Ikegawa; Matthew D Krasowski; Kuniko Mitamura; Takashi Iida
Chemical synthesis of the (25R)- and (25S)-epimers of 3α,7α,12α-trihydroxy-5α-cholestan-27-oic acid as well as their corresponding glycine and taurine conjugates.
Chemistry and physics of lipids 2011;164(5):368-77.
2011: Sean Ekins; Antony John Williams; Matthew D Krasowski; Joel S Freundlich
In silico repositioning of approved drugs for rare and neglected diseases.
Drug discovery today 2011;16(7-8):298-310.
2011: Matthew D Krasowski; Ai Ni; lee hagey; Sean Ekins
Evolution of promiscuous nuclear hormone receptors: LXR, FXR, VDR, PXR, and CAR.
Molecular and cellular endocrinology 2011;334(1-2):39-48.
2011: Matthew D Krasowski; Ni Ai; lee hagey; Erin M Kollitz; Seth W Kullman; Erica J Reschly; Sean Ekins
The evolution of farnesoid X, vitamin D, and pregnane X receptors: insights from the green-spotted pufferfish (Tetraodon nigriviridis) and other non-mammalian species.
BMC biochemistry 2011;12():5.
2010: Sandhya Kortagere; Matthew D Krasowski; Erica J Reschly; Madhukumar Venkatesh; venkatesh madhukumar; Sean Ekins
Evaluation of computational docking to identify pregnane X receptor agonists in the ToxCast database.
Environmental health perspectives 2010;118(10):1412-7.
2010: lee hagey; Takashi Lida; Hideyuki Tamegai; Shoujiro Ogawa; Mizuho Une; Kiyoshi Asahina; Kumiko Mushiake; Takaaki Goto; Nariyasu Mano; Junichi Goto; Matthew D Krasowski; Alan F Hofmann
Major biliary bile acids of the medaka (Oryzias latipes): 25R- and 25S-epimers of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoic acid.
Zoological science 2010;27(7):565-73.
2010: Deanna L Howarth; lee hagey; Sheran H W Law; Ni Ai; Matthew D Krasowski; Ekins Sean; John T Moore; Erin M Kollitz; David E Hinton; Seth W Kullman
Two farnesoid X receptor alpha isoforms in Japanese medaka (Oryzias latipes) are differentially activated in vitro.
Aquatic toxicology (Amsterdam, Netherlands) 2010;98(3):245-55.
2010: Michael J Lynch; Anthony F Pizon; Mohamed G Siam; Matthew D Krasowski
Clinical effects and toxicokinetic evaluation following massive topiramate ingestion.
Journal of medical toxicology : official journal of the American College of Medical Toxicology 2010;6(2):135-8.
2010: Brian R Smith; Maria Aguero-Rosenfeld; John Anastasi; Beverly Baron; Anders Berg; Jay L Bock; Sheldon Campbell; Kendall P Crookston; Robert Fitzgerald; Mark Fung; Richard Haspel; John G Howe; Jeffrey Jhang; Malek Kamoun; Susan Koethe; Matthew D Krasowski; Marie L Landry; Marisa B Marques; Henry M Rinder; William Roberts; William E Schreiber; Steven L Spitalnik; Christopher A Tormey; Paul Wolf; Yan Yun Wu
Educating medical students in laboratory medicine: a proposed curriculum.
American journal of clinical pathology 2010;133(4):533-42.
2010: lee hagey; Peter R Møller; Alan F Hofmann; Matthew D Krasowski
Diversity of bile salts in fish and amphibians: evolution of a complex biochemical pathway.
Physiological and biochemical zoology : PBZ 2010;83(2):308-21.
2010: Alan F Hofmann; lee hagey; Matthew D Krasowski
Bile salts of vertebrates: structural variation and possible evolutionary significance.
Journal of lipid research 2010;51(2):226-46.
2010: lee hagey; Nicolas Vidal; Alan F Hofmann; Matthew D Krasowski
Evolutionary diversity of bile salts in reptiles and mammals, including analysis of ancient human and extinct giant ground sloth coprolites.
BMC evolutionary biology 2010;10():133.
2009: Sean Ekins; Sandhya Kortagere; Manisha Iyer; Erica J Reschly; Markus A Lill; Matthew R Redinbo; Matthew D Krasowski
Challenges predicting ligand-receptor interactions of promiscuous proteins: the nuclear receptor PXR.
PLoS computational biology 2009;5(12):e1000594.
2009: Arunima Biswas (Basu); Sridhar Mani; Matthew R Redinbo; Matthew D Krasowski; Hao Li; Ekins Sean
Elucidating the 'Jekyll and Hyde' nature of PXR: the case for discovering antagonists or allosteric antagonists.
Pharmaceutical research 2009;26(8):1807-15.
2009: Matthew D Krasowski; Mohamed G Siam; Manisha Iyer; Anthony F Pizon; Spiros Giannoutsos; Sean Ekins
Chemoinformatic methods for predicting interference in drug of abuse/toxicology immunoassays.
Clinical chemistry 2009;55(6):1203-13.
2009: Matthew D Krasowski; Mohamed G Siam; Manisha Iyer; Sean Ekins
Molecular similarity methods for predicting cross-reactivity with therapeutic drug monitoring immunoassays.
Therapeutic drug monitoring 2009;31(3):337-44.
2009: Ni Ai; Matthew D Krasowski; WILLIAM J WELSH; Sean Ekins
Understanding nuclear receptors using computational methods.
Drug discovery today 2009;14(9-10):486-94.
2009: Sandhya Kortagere; Matthew D Krasowski; Sean Ekins
The importance of discerning shape in molecular pharmacology.
Trends in pharmacological sciences 2009;30(3):138-47.
2009: Anthony F Pizon; Anna R Schwartz; Leo M Shum; Jon C Rittenberger; Darla R Lower; Spiros Giannoutsos; Mohamed A Virji; Matthew D Krasowski
Toxicology laboratory analysis and human exposure to p-chloroaniline.
Clinical toxicology (Philadelphia, Pa.) 2009;47(2):132-6.
2009: Matthew D Krasowski; Anthony F Pizon; Mohamed G Siam; Spiros Giannoutsos; Manisha Iyer; Sean Ekins
Using molecular similarity to highlight the challenges of routine immunoassay-based drug of abuse/toxicology screening in emergency medicine.
BMC emergency medicine 2009;9():5.
2008: Bin Zhang; Wen Xie; Matthew D Krasowski
PXR: a xenobiotic receptor of diverse function implicated in pharmacogenetics.
Pharmacogenomics 2008;9(11):1695-709.
2008: Matthew D Krasowski; Erica J Reschly; Sean Ekins
Intrinsic disorder in nuclear hormone receptors.
Journal of proteome research 2008;7(10):4359-72.
2008: akash khandelwal; Matthew D Krasowski; Erica J Reschly; Michael W Sinz; Peter Swaan; Sean Ekins
Machine learning methods and docking for predicting human pregnane X receptor activation.
Chemical research in toxicology 2008;21(7):1457-67.
2008: Erica J Reschly; Ni Ai; Sean Ekins; WILLIAM J WELSH; lee hagey; Alan Hofmann; Matthew D Krasowski
Evolution of the bile salt nuclear receptor FXR in vertebrates.
Journal of lipid research 2008;49(7):1577-87.
2008: Sean Ekins; Manisha Iyer; Matthew D Krasowski; Evan D Kharasch
Molecular characterization of CYP2B6 substrates.
Current drug metabolism 2008;9(5):363-73.
2008: Erica J Reschly; Ni Ai; WILLIAM J WELSH; Sean Ekins; lee hagey; Matthew D Krasowski
Ligand specificity and evolution of liver X receptors.
The Journal of steroid biochemistry and molecular biology 2008;110(1-2):83-94.
2008: Sean Ekins; Erica J Reschly; lee hagey; Matthew D Krasowski
Evolution of pharmacologic specificity in the pregnane X receptor.
BMC evolutionary biology 2008;8():103.
2007: Elizabeth Greiner-Sosanko; Spiros Giannoutsos; Darla R Lower; Mohamed A Virji; Matthew D Krasowski
Drug monitoring: simultaneous analysis of lamotrigine, oxcarbazepine, 10-hydroxycarbazepine, and zonisamide by HPLC-UV and a rapid GC method using a nitrogen-phosphorus detector for levetiracetam.
Journal of chromatographic science 2007;45(9):616-22.
2007: Sean Ekins; Cheng Chang; Sridhar Mani; Matthew D Krasowski; Erica J Reschly; Manisha Iyer; Vladyslav Kholodovych; Ni Ai; WILLIAM J WELSH; Michael Sinz; Peter Swaan; Rachana Patel; Kenneth Bachmann
Human pregnane X receptor antagonists and agonists define molecular requirements for different binding sites.
Molecular pharmacology 2007;72(3):592-603.
2007: Jonathan R Genzen; Matthew D Krasowski
Resident training in clinical chemistry.
Clinics in laboratory medicine 2007;27(2):343-58; abstract vii.
2007: Beverly W Baron; Nancy J Zeleznik-Le; Miriam J Baron; Catherine Theisler; Dezheng Huo; Matthew D Krasowski; Michael J Thirman; Rebecca M Baron; Joseph M Baron
Repression of the PDCD2 gene by BCL6 and the implications for the pathogenesis of human B and T cell lymphomas.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(18):7449-54.
2007: Elizabeth Greiner-Sosanko; Darla R Lower; Mohamed A Virji; Matthew D Krasowski
Simultaneous determination of lamotrigine, zonisamide, and carbamazepine in human plasma by high-performance liquid chromatography.
Biomedical chromatography : BMC 2007;21(3):225-8.
2007: Erica J Reschly; Afonso Celso Dias Bainy; Jaco Joaquim Mattos; lee hagey; Nathan Bahary; Sripal R Mada; Junhai Ou; Raman Venkataramanan; Matthew D Krasowski
Functional evolution of the vitamin D and pregnane X receptors.
BMC evolutionary biology 2007;7():222.
2006: Manisha Iyer; Erica J Reschly; Matthew D Krasowski
Functional evolution of the pregnane X receptor.
Expert opinion on drug metabolism & toxicology 2006;2(3):381-97.
2006: Erica J Reschly; Matthew D Krasowski
Evolution and function of the NR1I nuclear hormone receptor subfamily (VDR, PXR, and CAR) with respect to metabolism of xenobiotics and endogenous compounds.
Current drug metabolism 2006;7(4):349-65.
2005: Matthew D Krasowski; Kazuto Yasuda; lee hagey; Erin G Schuetz
Evolutionary selection across the nuclear hormone receptor superfamily with a focus on the NR1I subfamily (vitamin D, pregnane X, and constitutive androstane receptors).
Nuclear receptor 2005;3():2.
2005: Emma E Thompson; Hala Kuttab-Boulos; Matthew D Krasowski; Anna Di Rienzo
Functional constraints on the constitutive androstane receptor inferred from human sequence variation and cross-species comparisons.
Human genomics 2005;2(3):168-78.
2005: Matthew D Krasowski; Kazuto Yasuda; lee hagey; Erin G Schuetz
Evolution of the pregnane x receptor: adaptation to cross-species differences in biliary bile salts.
Molecular endocrinology (Baltimore, Md.) 2005;19(7):1720-39.
2005: Matthew D Krasowski
GPI-15715 Guilford.
Current opinion in investigational drugs (London, England : 2000) 2005;6(1):90-8.
2003: Matthew D Krasowski
Contradicting a unitary theory of general anesthetic action: a history of three compounds from 1901 to 2001.
Bulletin of anesthesia history 2003;21(3):1, 4-8, 21 passim.
2002: Matthew D Krasowski; Xuan Hong; A J Hopfinger; Neil L Harrison
4D-QSAR analysis of a set of propofol analogues: mapping binding sites for an anesthetic phenol on the GABA(A) receptor.
Journal of medicinal chemistry 2002;45(15):3210-21.
2001: Matthew D Krasowski; K Nishikawa; N Nikolaeva; A Lin; Neil L Harrison
Methionine 286 in transmembrane domain 3 of the GABAA receptor beta subunit controls a binding cavity for propofol and other alkylphenol general anesthetics.
Neuropharmacology 2001;41(8):952-64.
2001: Ratnakumari Lingamaneni; Matthew D Krasowski; Andrew Jenkins; T Truong; A L Giunta; J Blackbeer; M B MacIver; Neil L Harrison; Hugh C Hemmings
Anesthetic properties of 4-iodopropofol: implications for mechanisms of anesthesia.
Anesthesiology 2001;94(6):1050-7.
2001: Matthew D Krasowski; Andrew Jenkins; P Flood; A Y Kung; A J Hopfinger; Neil L Harrison
General anesthetic potencies of a series of propofol analogs correlate with potency for potentiation of gamma-aminobutyric acid (GABA) current at the GABA(A) receptor but not with lipid solubility.
The Journal of pharmacology and experimental therapeutics 2001;297(1):338-51.
2000: Daniel S McGehee; Matthew D Krasowski; DL Fung; B Wilson; GA Gronert; J Moss
Cholinesterase inhibition by potato glycoalkaloids slows mivacurium metabolism.
Anesthesiology 2000;93(2):510-9.
2000: Pamela Flood; Matthew D Krasowski
Intravenous anesthetics differentially modulate ligand-gated ion channels.
Anesthesiology 2000;92(5):1418-25.
2000: Matthew D Krasowski
Differential modulatory actions of the volatile convulsant flurothyl and its anesthetic isomer at inhibitory ligand-gated ion channels.
Neuropharmacology 2000;39(7):1168-83.
2000: Matthew D Krasowski; Neil L Harrison
The actions of ether, alcohol and alkane general anaesthetics on GABAA and glycine receptors and the effects of TM2 and TM3 mutations.
British journal of pharmacology 2000;129(4):731-43.
1999: Matthew D Krasowski; Neil L Harrison
General anaesthetic actions on ligand-gated ion channels.
Cellular and molecular life sciences : CMLS 1999;55(10):1278-303.
1999: Gregg E Homanics; Neil L Harrison; Joseph J Quinlan; Matthew D Krasowski; CE Rick; Angel L De Blas; Ashok K Mehta; F Kist; Robert M Mihalek; JJ Aul; Leonard L Firestone
Normal electrophysiological and behavioral responses to ethanol in mice lacking the long splice variant of the gamma2 subunit of the gamma-aminobutyrate type A receptor.
Neuropharmacology 1999;38(2):253-65.
1998: Matthew D Krasowski; SE Finn; Q Ye; Neil L Harrison
Trichloroethanol modulation of recombinant GABAA, glycine and GABA rho 1 receptors.
The Journal of pharmacology and experimental therapeutics 1998;284(3):934-42.
1998: Matthew D Krasowski; VV Koltchine; CE Rick; Q Ye; SE Finn; Neil L Harrison
Propofol and other intravenous anesthetics have sites of action on the gamma-aminobutyric acid type A receptor distinct from that for isoflurane.
Molecular pharmacology 1998;53(3):530-8.
1998: Matthew D Krasowski; CE Rick; Neil L Harrison; Leonard L Firestone; Gregg E Homanics
A deficit of functional GABA(A) receptors in neurons of beta 3 subunit knockout mice.
Neuroscience letters 1998;240(2):81-4.
1997: S John Mihic; Q Ye; MJ Wick; VV Koltchine; Matthew D Krasowski; SE Finn; Maria Paola Mascia; C Fernando Valenzuela; K K Hanson; E P Greenblatt; R Adron Harris; Neil L Harrison
Sites of alcohol and volatile anaesthetic action on GABA(A) and glycine receptors.
Nature 1997;389(6649):385-9.
1997: Matthew D Krasowski; S M O'Shea; CE Rick; Paul J Whiting; Karen L Hadingham; C Czajkowski; Neil L Harrison
Alpha subunit isoform influences GABA(A) receptor modulation by propofol.
Neuropharmacology 1997;36(7):941-9.
1997: Matthew D Krasowski; Daniel S McGehee; J Moss
Natural inhibitors of cholinesterases: implications for adverse drug reactions.
Canadian journal of anaesthesia = Journal canadien d'anesthésie 1997;44(5 Pt 1):525-34.
1997: Gregg E Homanics; Timothy M DeLorey; Leonard L Firestone; Joseph J Quinlan; Adrian Handforth; Neil L Harrison; Matthew D Krasowski; CE Rick; Esa R Korpi; Rauno Mäkelä; M H Brilliant; N Hagiwara; Carolyn Ferguson; K Snyder; Richard W Olsen
Mice devoid of gamma-aminobutyrate type A receptor beta3 subunit have epilepsy, cleft palate, and hypersensitive behavior.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(8):4143-8.
1996: Mark Stein; Matthew D Krasowski; Bennett L Leventhal; W Phillips; B G Bender
Behavioral and cognitive effects of methylxanthines. A meta-analysis of theophylline and caffeine.
Archives of pediatrics & adolescent medicine 1996;150(3):284-8.
1995: Edwin H Cook; Mark Stein; Matthew D Krasowski; Nancy J Cox; D M Olkon; J E Kieffer; Bennett L Leventhal
Association of attention-deficit disorder and the dopamine transporter gene.
American journal of human genetics 1995;56(4):993-8.
1994: Mark Stein; E Szumowski; R Sandoval; D Nadelman; T O'Brien; Matthew D Krasowski; W Phillips
Psychometric properties of the children's atypical development scale.
Journal of abnormal child psychology 1994;22(2):167-76.