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Marcela Krecmerová

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Marcela Krecmerová; Johan Neyts; Petra Sázelová; George Stepan; Joeri Auwerx; Martin Dračínský; Nesya Goris; Petr Jansa; Václav Kašička; Eleonóra Kiss; Zlatko Janeba
9-[2-(R)-(Phosphonomethoxy)propyl]-2,6-diaminopurine (R)-PMPDAP and its prodrugs: optimized preparation, including identification of by-products formed, and antiviral evaluation in vitro.
Tomáš Tichý; Robert Snoeck; Graciela Andrei; Jan Balzarini; Martin Dračínský; Marcela Krecmerová
Synthesis and antiviral activities of hexadecyloxypropyl prodrugs of acyclic nucleoside phosphonates containing guanine or hypoxanthine and a (S)-HPMP or PEE acyclic moiety.
Sophie Duraffour; Daniel Garin; Graciela Andrei; Jean-Marc Crance; Dimitri Topalis; Marcela Krecmerová; Robert Snoeck
Mutations conferring resistance to viral DNA polymerase inhibitors in camelpox virus give different drug-susceptibility profiles in vaccinia virus.

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All Publications

2013: Marcela Krecmerová; Johan Neyts; Petra Sázelová; George Stepan; Joeri Auwerx; Martin Dračínský; Nesya Goris; Petr Jansa; Václav Kašička; Eleonóra Kiss; Zlatko Janeba
9-[2-(R)-(Phosphonomethoxy)propyl]-2,6-diaminopurine (R)-PMPDAP and its prodrugs: optimized preparation, including identification of by-products formed, and antiviral evaluation in vitro.
Bioorganic & medicinal chemistry 2013;21(5):1199-208.
2012: Tomáš Tichý; Robert Snoeck; Graciela Andrei; Jan Balzarini; Martin Dračínský; Marcela Krecmerová
Synthesis and antiviral activities of hexadecyloxypropyl prodrugs of acyclic nucleoside phosphonates containing guanine or hypoxanthine and a (S)-HPMP or PEE acyclic moiety.
European journal of medicinal chemistry 2012;55():307-14.
2012: Sophie Duraffour; Daniel Garin; Graciela Andrei; Jean-Marc Crance; Dimitri Topalis; Marcela Krecmerová; Robert Snoeck
Mutations conferring resistance to viral DNA polymerase inhibitors in camelpox virus give different drug-susceptibility profiles in vaccinia virus.
Journal of virology 2012;86(13):7310-25.
2012: Jana Brabcová; Lucie Janská; Marcela Krecmerová; Jiří Blažek; Marie Zarevúcka
Lipases as tools in the synthesis of prodrugs from racemic 9-(2,3-dihydroxypropyl)adenine.
Molecules (Basel, Switzerland) 2012;17(12):13813-24.
2011: D Topalis; Ilya Lebeau; Marcela Krecmerová; Graciela Andrei; Robert Snoeck
Activities of different classes of acyclic nucleoside phosphonates against BK virus in primary human renal cells.
Antimicrobial agents and chemotherapy 2011;55(5):1961-7.
2010: Marcela Krecmerová; Antonín Holý; Graciela Andrei; Karel Pomeisl; Tomás Tichý; Petra Brehová; Milena Masojídková; Martin Dracínský; Radek Pohl; Genevieve Laflamme; Lieve Naesens; Hon Hui; Tomas Cihlar; Johan Neyts; Erik De Clercq; Jan Balzarini; Robert Snoeck
Synthesis of ester prodrugs of 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-2,6-diaminopurine (HPMPDAP) as anti-poxvirus agents.
Journal of medicinal chemistry 2010;53(19):6825-37.
2010: Dianne T Keough; Dana Hocková; Marcela Krecmerová; Michal Cesnek; Antonín Holý; Lieve Naesens; Ian M Brereton; Donald J Winzor; John de Jersey; Luke W Guddat
Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase: a target for anti-malarial chemotherapy.
Molecular and biochemical parasitology 2010;173(2):165-9.
2010: Marcela Krecmerová; Milena Masojídková; Antonín Holý
Acyclic nucleoside phosphonates with 5-azacytosine base moiety substituted in C-6 position.
Bioorganic & medicinal chemistry 2010;18(1):387-95.
2008: Don B Gammon; Robert Snoeck; Pierre Fiten; Marcela Krecmerová; Antonín Holý; Erik De Clercq; Ghislain Opdenakker; David H Evans; Graciela Andrei
Mechanism of antiviral drug resistance of vaccinia virus: identification of residues in the viral DNA polymerase conferring differential resistance to antipoxvirus drugs.
Journal of virology 2008;82(24):12520-34.
2008: Marleen Renders; Roel Lievrouw; Marcela Krecmerová; Antonín Holý; Piet Herdewijn
Enzymatic polymerization of phosphonate nucleosides.
Chembiochem : a European journal of chemical biology 2008;9(17):2883-8.
2008: Lieve Naesens; Graciela Andrei; Ivan Votruba; Marcela Krecmerová; Antonín Holý; Johan Neyts; Erik De Clercq; Robert Snoeck
Intracellular metabolism of the new antiviral compound 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine.
Biochemical pharmacology 2008;76(8):997-1005.
2008: Martin Dracínský; Marcela Krecmerová; Antonín Holý
Study of chemical stability of antivirally active 5-azacytosine acyclic nucleoside phosphonates using NMR spectroscopy.
Bioorganic & medicinal chemistry 2008;16(14):6778-82.
2008: Miroslav Hájek; Ivan Votruba; Antonín Holý; Marcela Krecmerová; Eva Tloust'ová
Alpha anomer of 5-aza-2'-deoxycytidine down-regulates hTERT mRNA expression in human leukemia HL-60 cells.
Biochemical pharmacology 2008;75(4):965-72.
2007: Sophie Duraffour; Robert Snoeck; Marcela Krecmerová; Joost J van den Oord; Rita De Vos; Antonin Holy; Jean-Marc Crance; Daniel Garin; Erik De Clercq; Graciela Andrei
Activities of several classes of acyclic nucleoside phosphonates against camelpox virus replication in different cell culture models.
Antimicrobial agents and chemotherapy 2007;51(12):4410-9.
2007: Marcela Krecmerová; Antonín Holý; Radek Pohl; Milena Masojídková; Graciela Andrei; Lieve Naesens; Johan Neyts; Jan Balzarini; Erik De Clercq; Robert Snoeck
Ester prodrugs of cyclic 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine: synthesis and antiviral activity.
Journal of medicinal chemistry 2007;50(23):5765-72.
2007: Ilya Lebeau; Graciela Andrei; Marcela Krecmerová; Erik De Clercq; Antonin Holy; Robert Snoeck
Inhibitory activities of three classes of acyclic nucleoside phosphonates against murine polyomavirus and primate simian virus 40 strains.
Antimicrobial agents and chemotherapy 2007;51(6):2268-73.
2007: Marcela Krecmerová; Antonín Holý; Alois Pískala; Milena Masojídková; Graciela Andrei; Lieve Naesens; Johan Neyts; Jan Balzarini; Erik De Clercq; Robert Snoeck
Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds.
Journal of medicinal chemistry 2007;50(5):1069-77.
2007: Marleen Renders; Gert Emmerechts; Jef Rozenski; Marcela Krecmerová; Antonín Holý; Piet Herdewijn
Enzymatic synthesis of phosphonomethyl oligonucleotides by therminator polymerase.
Angewandte Chemie (International ed. in English) 2007;46(14):2501-4.
2006: Petr Potmesil; Marcela Krecmerová; Eva Kmonícková; Antonín Holý; Zdenek Zídek
Nucleotide analogues with immunobiological properties: 9-[2-Hydroxy-3-(phosphonomethoxy)propyl]-adenine (HPMPA), -2,6-diaminopurine (HPMPDAP), and their N6-substituted derivatives.
European journal of pharmacology 2006;540(1-3):191-9.
1999: Ivan Votruba; Marcela Krecmerová; Hubert Hrebabecký; Antonín Holý
Inhibitory potency of 5-benzyluracil, 5-phenylcytosine and 5-phenylpyrimidin-2-one nucleosides against uridine phosphorylase from mouse leukemic L1210 cells.
Nucleosides & nucleotides 1999;18(11-12):2551-64.